RECQL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a helicase that is important for genome stability. The encoded protein also prevents aberrant homologous recombination by displacing RAD51 from ssDNA. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.21577668
2protein localization to kinetochore (GO:0034501)5.40291750
3proline biosynthetic process (GO:0006561)4.99100570
4protein localization to chromosome, centromeric region (GO:0071459)4.55991504
5mannose metabolic process (GO:0006013)4.49659437
6DNA unwinding involved in DNA replication (GO:0006268)4.40045120
7dosage compensation (GO:0007549)4.27935441
8proline metabolic process (GO:0006560)4.27786549
9negative regulation of histone methylation (GO:0031061)4.03629304
10positive regulation of gamma-delta T cell activation (GO:0046645)3.99979882
11antigen processing and presentation of endogenous antigen (GO:0019883)3.96519238
12protein localization to chromosome (GO:0034502)3.94822918
13pre-miRNA processing (GO:0031054)3.75069605
14folic acid-containing compound biosynthetic process (GO:0009396)3.73334184
15regulation of histone H3-K9 methylation (GO:0051570)3.72693034
16activation of Rac GTPase activity (GO:0032863)3.59209655
17negative regulation of erythrocyte differentiation (GO:0045647)3.58804937
18poly(A)+ mRNA export from nucleus (GO:0016973)3.55175210
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.50587799
20antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.50587799
21retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.45645206
22NIK/NF-kappaB signaling (GO:0038061)3.44595570
23positive regulation of Cdc42 GTPase activity (GO:0043089)3.44529708
24regulation of ARF GTPase activity (GO:0032312)3.43775072
25negative regulation of viral release from host cell (GO:1902187)3.39917968
26snRNA transcription (GO:0009301)3.39223289
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.36609708
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36609708
29regulation of gamma-delta T cell differentiation (GO:0045586)3.36434368
30stress granule assembly (GO:0034063)3.35480268
31B cell receptor signaling pathway (GO:0050853)3.27631577
32mitotic sister chromatid cohesion (GO:0007064)3.20607383
33regulation of gamma-delta T cell activation (GO:0046643)3.18798330
34histone lysine demethylation (GO:0070076)3.17054658
35positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.12255646
36histone H3-K36 demethylation (GO:0070544)3.11777936
37IMP biosynthetic process (GO:0006188)3.10445879
38semaphorin-plexin signaling pathway (GO:0071526)3.09656005
39intracellular estrogen receptor signaling pathway (GO:0030520)3.06820396
40histone H4 deacetylation (GO:0070933)3.05699729
41regulation of cholesterol homeostasis (GO:2000188)3.05284795
42nuclear pore complex assembly (GO:0051292)3.04980447
43regulation of interferon-beta biosynthetic process (GO:0045357)3.04729362
44histone demethylation (GO:0016577)3.04093863
45N-glycan processing (GO:0006491)3.03277292
46mitotic nuclear envelope disassembly (GO:0007077)3.00078403
47regulation of chromatin binding (GO:0035561)2.99152247
48Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97079280
49nuclear pore organization (GO:0006999)2.96598459
50nucleobase biosynthetic process (GO:0046112)2.96400435
51barbed-end actin filament capping (GO:0051016)2.95490558
52protein kinase C signaling (GO:0070528)2.95060601
53regulation of histone H3-K27 methylation (GO:0061085)2.92107265
54regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92025368
55snRNA metabolic process (GO:0016073)2.91698604
56spliceosomal tri-snRNP complex assembly (GO:0000244)2.90908924
57sister chromatid segregation (GO:0000819)2.90764179
58positive thymic T cell selection (GO:0045059)2.90646266
59attachment of spindle microtubules to kinetochore (GO:0008608)2.90177702
60mitotic chromosome condensation (GO:0007076)2.89941889
61GDP-mannose metabolic process (GO:0019673)2.88653146
62regulation of sister chromatid cohesion (GO:0007063)2.87878512
63glial cell proliferation (GO:0014009)2.87269524
64protein retention in ER lumen (GO:0006621)2.86576569
65snRNA processing (GO:0016180)2.86416912
66negative regulation of gene expression, epigenetic (GO:0045814)2.86212536
67histone H3-K9 demethylation (GO:0033169)2.85369698
68DNA damage response, signal transduction resulting in transcription (GO:0042772)2.85071614
69histone H2A acetylation (GO:0043968)2.84937269
70negative regulation of granulocyte differentiation (GO:0030853)2.84103111
71* DNA duplex unwinding (GO:0032508)2.83748419
72purine nucleobase biosynthetic process (GO:0009113)2.80457920
73* DNA geometric change (GO:0032392)2.80320914
74translesion synthesis (GO:0019985)2.78576439
75regulation of hippo signaling (GO:0035330)2.77335269
76negative regulation of telomerase activity (GO:0051974)2.76020100
77peptidyl-lysine dimethylation (GO:0018027)2.73602191
78positive regulation of gene expression, epigenetic (GO:0045815)2.73587388
79maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73183126
80regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.72755215
81regulation of cholesterol metabolic process (GO:0090181)2.71881405
82histone H4-K8 acetylation (GO:0043982)2.71377415
83histone H4-K5 acetylation (GO:0043981)2.71377415
84cell-substrate adherens junction assembly (GO:0007045)2.71251700
85focal adhesion assembly (GO:0048041)2.71251700
86histone H2A monoubiquitination (GO:0035518)2.70923531
87regulation of double-strand break repair via homologous recombination (GO:0010569)2.70886496
88nuclear envelope disassembly (GO:0051081)2.70034981
89membrane disassembly (GO:0030397)2.70034981
90adherens junction assembly (GO:0034333)2.69646401
91regulation of B cell receptor signaling pathway (GO:0050855)2.68566828
92glutamine family amino acid biosynthetic process (GO:0009084)2.67206903
93histone H3-K9 modification (GO:0061647)2.66999391
94rRNA catabolic process (GO:0016075)2.66341061
95regulation of spindle organization (GO:0090224)2.65753726
96glycine metabolic process (GO:0006544)2.65589019
97activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.65285921
98regulation of granulocyte differentiation (GO:0030852)2.65216868
99plasma lipoprotein particle assembly (GO:0034377)2.64864198
100regulation of telomere maintenance via telomerase (GO:0032210)2.64642798
101pinocytosis (GO:0006907)2.64017512
102regulation of cholesterol biosynthetic process (GO:0045540)2.63306132
103IMP metabolic process (GO:0046040)2.63019111
104protein demethylation (GO:0006482)2.63013470
105protein dealkylation (GO:0008214)2.63013470
106apoptotic process involved in morphogenesis (GO:0060561)2.62427992
107intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.62400723
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.61801473
109modulation by symbiont of host immune response (GO:0052553)2.61801473
110positive regulation by symbiont of host defense response (GO:0052509)2.61801473
111modulation by symbiont of host defense response (GO:0052031)2.61801473
112modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61801473
113modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61801473
114mitotic sister chromatid segregation (GO:0000070)2.61219054
115DNA strand elongation involved in DNA replication (GO:0006271)2.60938244
116urea cycle (GO:0000050)2.60483197
117positive regulation of protein deacetylation (GO:0090312)2.60223825
118trophectodermal cell differentiation (GO:0001829)2.59997801
119tetrahydrofolate metabolic process (GO:0046653)2.59771302
120histone H4-K12 acetylation (GO:0043983)2.59625259
121one-carbon metabolic process (GO:0006730)2.59582174
122cellular response to epidermal growth factor stimulus (GO:0071364)2.59419985
123DNA replication initiation (GO:0006270)2.58520811
124positive regulation of histone deacetylation (GO:0031065)2.58098803
125DNA strand elongation (GO:0022616)2.57492898
126chromatin silencing (GO:0006342)2.56481722
127negative regulation of cell size (GO:0045792)2.56160992
128positive regulation of B cell differentiation (GO:0045579)2.55744746
129immunoglobulin mediated immune response (GO:0016064)2.55171998
130regulation of RNA export from nucleus (GO:0046831)2.55137598
131modulation by virus of host process (GO:0019054)2.55037190
132pentose-phosphate shunt (GO:0006098)2.54858894
133retrograde transport, endosome to Golgi (GO:0042147)2.54112795
134positive regulation of nuclease activity (GO:0032075)2.53980321
135folic acid metabolic process (GO:0046655)2.53574141
136regulation of mitotic spindle organization (GO:0060236)2.53059550
137heterochromatin organization (GO:0070828)2.52997929
138regulation of viral release from host cell (GO:1902186)2.49357904
139regulation of translational fidelity (GO:0006450)2.48971479
140regulation of nucleobase-containing compound transport (GO:0032239)2.48655175
141negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48562512
142activation of JUN kinase activity (GO:0007257)2.46879933
143histone H3-K9 methylation (GO:0051567)2.46678936
144DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.46153760
145glucose 6-phosphate metabolic process (GO:0051156)2.45929662
146regulation of centriole replication (GO:0046599)2.45465730
147regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45446135
148negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44677447
149UV protection (GO:0009650)2.43726287
150DNA damage induced protein phosphorylation (GO:0006975)2.43195040
151regulation of glucose import in response to insulin stimulus (GO:2001273)2.43017268
152actin nucleation (GO:0045010)2.42992404
153B cell mediated immunity (GO:0019724)2.42811073
154negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.42516701
155receptor recycling (GO:0001881)2.42347988
156positive regulation of chromosome segregation (GO:0051984)2.42070218
157protein-lipid complex assembly (GO:0065005)2.40858922
158L-alpha-amino acid transmembrane transport (GO:1902475)2.40160587
159activation of MAPKKK activity (GO:0000185)2.39358110
160regulation of extracellular matrix disassembly (GO:0010715)2.38724153
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.38320894
162modulation by symbiont of host cellular process (GO:0044068)2.37499596
163negative regulation of fatty acid biosynthetic process (GO:0045717)2.37235983
164gene silencing (GO:0016458)2.36875646
165antigen processing and presentation via MHC class Ib (GO:0002475)2.35401745
166Golgi transport vesicle coating (GO:0048200)2.35384944
167COPI coating of Golgi vesicle (GO:0048205)2.35384944
168cytidine deamination (GO:0009972)2.35080239
169cytidine metabolic process (GO:0046087)2.35080239
170cytidine catabolic process (GO:0006216)2.35080239
171* DNA conformation change (GO:0071103)2.34940840
172glucose catabolic process (GO:0006007)2.34616044
173positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.33741383
174branching involved in mammary gland duct morphogenesis (GO:0060444)2.33569171
175protein-DNA complex disassembly (GO:0032986)2.33503472
176nucleosome disassembly (GO:0006337)2.33503472
177urea metabolic process (GO:0019627)2.32646007
178regulation of integrin activation (GO:0033623)2.31637013
179regulation of ARF protein signal transduction (GO:0032012)2.31178900
180epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31125228
181regulation of nuclease activity (GO:0032069)2.30559156
182positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.30333955
183desmosome organization (GO:0002934)2.29670859
184cell volume homeostasis (GO:0006884)2.28121981
185positive regulation of keratinocyte differentiation (GO:0045618)2.27684604

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.54341738
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.68024575
3MYC_22102868_ChIP-Seq_BL_Human3.55152603
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.48996604
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.29226603
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.63233465
7VDR_21846776_ChIP-Seq_THP-1_Human2.42572117
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32479502
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.15266006
10CIITA_25753668_ChIP-Seq_RAJI_Human2.05092944
11ZNF263_19887448_ChIP-Seq_K562_Human2.00155584
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97676737
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96969138
14E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85916687
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.83156367
16ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79505421
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76831399
18* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.76596072
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.72299678
20SCL_19346495_ChIP-Seq_HPC-7_Human1.71978766
21TCF7_22412390_ChIP-Seq_EML_Mouse1.71654482
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68562128
23ESR2_21235772_ChIP-Seq_MCF-7_Human1.66999523
24SMC4_20622854_ChIP-Seq_HELA_Human1.65897749
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64246304
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.63304140
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.62527739
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57790027
29UTX_26944678_Chip-Seq_JUKART_Human1.56894000
30ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.55302969
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54904154
32MAF_26560356_Chip-Seq_TH1_Human1.52012262
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51205975
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51187986
35KDM2B_26808549_Chip-Seq_K562_Human1.50329026
36CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49845247
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.49460939
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49386742
39STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49227331
40RUNX1_27514584_Chip-Seq_MCF-7_Human1.48592514
41KDM2B_26808549_Chip-Seq_DND41_Human1.48341396
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48006727
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.47939701
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47480452
45SA1_27219007_Chip-Seq_ERYTHROID_Human1.46640557
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44333087
47CREB1_26743006_Chip-Seq_LNCaP_Human1.43707475
48XRN2_22483619_ChIP-Seq_HELA_Human1.43596911
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42008048
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40632870
51KDM5A_27292631_Chip-Seq_BREAST_Human1.36034868
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35409026
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35028241
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33146047
55MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31998599
56AR_21909140_ChIP-Seq_LNCAP_Human1.31299270
57GABP_19822575_ChIP-Seq_HepG2_Human1.30314229
58KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28983728
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28953188
60TP53_22127205_ChIP-Seq_IMR90_Human1.28903849
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28334486
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27920540
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27749279
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27221920
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.26444610
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26297244
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.26079610
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25224594
69MYB_26560356_Chip-Seq_TH1_Human1.24637307
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.24102382
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.23351894
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23316432
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23097201
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22953079
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22876986
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20773109
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20457901
78CTCF_21964334_Chip-Seq_Bcells_Human1.19412230
79VDR_24763502_ChIP-Seq_THP-1_Human1.18956852
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18889134
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18269518
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17936724
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.16327604
84CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16078446
85RARA_24833708_ChIP-Seq_LIVER_Mouse1.15991741
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.15301435
87STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15193480
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14460606
89LXR_22292898_ChIP-Seq_THP-1_Human1.14099755
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13840905
91MAF_26560356_Chip-Seq_TH2_Human1.13236878
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13171445
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13126310
94RARB_24833708_ChIP-Seq_LIVER_Mouse1.12774048
95SPI1_23547873_ChIP-Seq_NB4_Human1.12592216
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.11873249
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11663645
98E2F1_20622854_ChIP-Seq_HELA_Human1.11621284
99MYB_26560356_Chip-Seq_TH2_Human1.11355977
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11018888
101TP63_22573176_ChIP-Seq_HFKS_Human1.10810961
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10579090
103PHF8_20622854_ChIP-Seq_HELA_Human1.09004425
104KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.08976559
105MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08848232
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08646721
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08365617
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08239763
109NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07435283
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06660388
111GATA1_19941826_ChIP-Seq_K562_Human1.06242251
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06172859
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06003073
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05395191
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04666214
116SPI1_23127762_ChIP-Seq_K562_Human1.04337079
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03709218
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.02702655
119FOXP3_21729870_ChIP-Seq_TREG_Human1.02298499
120* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01251981
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01024531
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00893179
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99683742
124MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99291973
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99018224
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.98479103
127RACK7_27058665_Chip-Seq_MCF-7_Human0.98087700
128* NANOG_21062744_ChIP-ChIP_HESCs_Human0.96438859
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95886414
130NCOR1_26117541_ChIP-Seq_K562_Human0.95772411
131* BCOR_27268052_Chip-Seq_Bcells_Human0.95420832
132P68_20966046_ChIP-Seq_HELA_Human0.95075367
133ETS1_20019798_ChIP-Seq_JURKAT_Human0.93579352
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93213791
135GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93103192
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92571282
137NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92406136
138* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92100852
139ATF3_27146783_Chip-Seq_COLON_Human0.91593594
140* BCL6_27268052_Chip-Seq_Bcells_Human0.89402633
141VDR_23849224_ChIP-Seq_CD4+_Human0.89344279
142ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88812252
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88647988
144E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.88551630
145TFEB_21752829_ChIP-Seq_HELA_Human0.87421856
146GATA6_25053715_ChIP-Seq_YYC3_Human0.86910502
147HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86558573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.47435548
2MP0003693_abnormal_embryo_hatching3.19150234
3MP0008260_abnormal_autophagy3.09705307
4MP0005451_abnormal_body_composition3.04833053
5MP0003111_abnormal_nucleus_morphology2.93484128
6MP0010234_abnormal_vibrissa_follicle2.86976899
7MP0003123_paternal_imprinting2.65959238
8MP0005360_urolithiasis2.43000573
9MP0010094_abnormal_chromosome_stability2.39107779
10MP0010352_gastrointestinal_tract_polyps2.29712756
11* MP0003077_abnormal_cell_cycle2.25932777
12MP0003121_genomic_imprinting2.25667351
13MP0000569_abnormal_digit_pigmentation2.24965926
14MP0009840_abnormal_foam_cell2.22136805
15MP0003705_abnormal_hypodermis_morpholog2.11818429
16MP0005076_abnormal_cell_differentiation2.08247421
17MP0001800_abnormal_humoral_immune2.08076162
18MP0000003_abnormal_adipose_tissue1.91861632
19MP0000678_abnormal_parathyroid_gland1.91500195
20MP0001835_abnormal_antigen_presentation1.89183050
21MP0005501_abnormal_skin_physiology1.84740386
22MP0004858_abnormal_nervous_system1.83296794
23MP0003787_abnormal_imprinting1.79143966
24MP0005365_abnormal_bile_salt1.77017838
25MP0001873_stomach_inflammation1.72418588
26MP0002398_abnormal_bone_marrow1.71634038
27MP0004185_abnormal_adipocyte_glucose1.71241839
28MP0000685_abnormal_immune_system1.69804601
29MP0008995_early_reproductive_senescence1.67047762
30MP0010307_abnormal_tumor_latency1.66345567
31MP0005387_immune_system_phenotype1.65905649
32MP0001790_abnormal_immune_system1.65905649
33MP0003453_abnormal_keratinocyte_physiol1.65253894
34MP0002396_abnormal_hematopoietic_system1.58942695
35MP0006054_spinal_hemorrhage1.58060952
36MP0004264_abnormal_extraembryonic_tissu1.58018403
37MP0003566_abnormal_cell_adhesion1.57875925
38MP0005083_abnormal_biliary_tract1.57130211
39MP0002089_abnormal_postnatal_growth/wei1.55602541
40MP0008058_abnormal_DNA_repair1.55583431
41MP0000490_abnormal_crypts_of1.53293540
42MP0003300_gastrointestinal_ulcer1.51738558
43MP0002452_abnormal_antigen_presenting1.51469181
44MP0000689_abnormal_spleen_morphology1.51240478
45MP0004957_abnormal_blastocyst_morpholog1.50364865
46MP0003763_abnormal_thymus_physiology1.50047449
47MP0005375_adipose_tissue_phenotype1.48435037
48MP0002132_abnormal_respiratory_system1.46912827
49MP0002139_abnormal_hepatobiliary_system1.46073711
50MP0003656_abnormal_erythrocyte_physiolo1.44952002
51MP0002722_abnormal_immune_system1.44293583
52MP0005666_abnormal_adipose_tissue1.43009033
53MP0002796_impaired_skin_barrier1.39601202
54MP0002249_abnormal_larynx_morphology1.38138923
55MP0000350_abnormal_cell_proliferation1.37899608
56MP0003183_abnormal_peptide_metabolism1.37767356
57MP0005409_darkened_coat_color1.35190789
58MP0003806_abnormal_nucleotide_metabolis1.35114824
59MP0000716_abnormal_immune_system1.35114271
60MP0001348_abnormal_lacrimal_gland1.34974885
61MP0001730_embryonic_growth_arrest1.34177093
62MP0000609_abnormal_liver_physiology1.32396842
63MP0002420_abnormal_adaptive_immunity1.31772495
64MP0001819_abnormal_immune_cell1.30495127
65MP0010329_abnormal_lipoprotein_level1.29319056
66MP0008057_abnormal_DNA_replication1.28699023
67MP0002429_abnormal_blood_cell1.28563090
68MP0000858_altered_metastatic_potential1.27621560
69MP0003252_abnormal_bile_duct1.27130990
70MP0001666_abnormal_nutrient_absorption1.26143975
71MP0002019_abnormal_tumor_incidence1.24206051
72MP0003172_abnormal_lysosome_physiology1.23150093
73MP0005397_hematopoietic_system_phenotyp1.22804858
74MP0001545_abnormal_hematopoietic_system1.22804858
75MP0004808_abnormal_hematopoietic_stem1.22522483
76MP0002723_abnormal_immune_serum1.18885422
77MP0003303_peritoneal_inflammation1.18755904
78MP0005085_abnormal_gallbladder_physiolo1.18262698
79MP0005671_abnormal_response_to1.17475156
80MP0008877_abnormal_DNA_methylation1.16867403
81MP0010155_abnormal_intestine_physiology1.13648877
82MP0009278_abnormal_bone_marrow1.12821570
83MP0000681_abnormal_thyroid_gland1.11675226
84MP0000703_abnormal_thymus_morphology1.11108607
85MP0005621_abnormal_cell_physiology1.09323320
86MP0001849_ear_inflammation1.08777368
87MP0005384_cellular_phenotype1.06080920
88MP0002086_abnormal_extraembryonic_tissu1.04772139
89MP0002138_abnormal_hepatobiliary_system1.02730560
90MP0001672_abnormal_embryogenesis/_devel1.02353136
91MP0005380_embryogenesis_phenotype1.02353136
92MP0003866_abnormal_defecation1.02342096
93MP0004233_abnormal_muscle_weight1.01600057
94MP0003191_abnormal_cellular_cholesterol1.00655156
95MP0009672_abnormal_birth_weight1.00234269
96MP0001697_abnormal_embryo_size1.00205882
97MP0002080_prenatal_lethality1.00017884
98MP0002098_abnormal_vibrissa_morphology0.98950665
99MP0009384_cardiac_valve_regurgitation0.97263204
100MP0008874_decreased_physiological_sensi0.97091286
101MP0005464_abnormal_platelet_physiology0.96815891
102MP0004947_skin_inflammation0.96214202
103MP0009931_abnormal_skin_appearance0.95812135
104MP0005000_abnormal_immune_tolerance0.94871001
105MP0000598_abnormal_liver_morphology0.92242455
106MP0003984_embryonic_growth_retardation0.90274398
107MP0003786_premature_aging0.89782877
108MP0000313_abnormal_cell_death0.89386087
109MP0002088_abnormal_embryonic_growth/wei0.89032418
110MP0000465_gastrointestinal_hemorrhage0.88678186
111MP0005310_abnormal_salivary_gland0.87812936
112MP0005220_abnormal_exocrine_pancreas0.87779057
113MP0004381_abnormal_hair_follicle0.87532683
114MP0002166_altered_tumor_susceptibility0.87430977
115MP0001216_abnormal_epidermal_layer0.87100172
116MP0000477_abnormal_intestine_morphology0.85755222
117MP0002970_abnormal_white_adipose0.85552462
118MP0008007_abnormal_cellular_replicative0.84588708
119MP0001845_abnormal_inflammatory_respons0.84385225
120MP0002419_abnormal_innate_immunity0.84267426
121MP0004197_abnormal_fetal_growth/weight/0.82615283
122MP0005025_abnormal_response_to0.81864566
123MP0002254_reproductive_system_inflammat0.81855040
124MP0003436_decreased_susceptibility_to0.81776777
125MP0005174_abnormal_tail_pigmentation0.81240991
126MP0002085_abnormal_embryonic_tissue0.80388992
127MP0000371_diluted_coat_color0.80186451
128MP0000427_abnormal_hair_cycle0.80116440
129MP0005075_abnormal_melanosome_morpholog0.79839424
130MP0003091_abnormal_cell_migration0.79373483
131MP0009333_abnormal_splenocyte_physiolog0.78803000
132MP0002405_respiratory_system_inflammati0.78649369
133MP0000013_abnormal_adipose_tissue0.77382344
134MP0003879_abnormal_hair_cell0.72624279
135MP0003115_abnormal_respiratory_system0.70663016
136MP0010630_abnormal_cardiac_muscle0.69326777
137MP0002009_preneoplasia0.68596664
138MP0000367_abnormal_coat/_hair0.67867305

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.80347557
2Impulsivity (HP:0100710)4.20501726
3Breast hypoplasia (HP:0003187)4.05149279
4Cortical dysplasia (HP:0002539)3.77767819
5Periodontitis (HP:0000704)3.39655555
6Flat acetabular roof (HP:0003180)3.36023959
7Astrocytoma (HP:0009592)3.31006825
8Abnormality of the astrocytes (HP:0100707)3.31006825
9Agammaglobulinemia (HP:0004432)3.16618335
10Gastrointestinal inflammation (HP:0004386)3.11645876
11Colitis (HP:0002583)3.10202759
12Inflammation of the large intestine (HP:0002037)2.97086628
13Hemorrhage of the eye (HP:0011885)2.89001361
14Abnormality of the fingertips (HP:0001211)2.84598256
15Deep venous thrombosis (HP:0002625)2.82477196
16Shawl scrotum (HP:0000049)2.79437123
17Reticulocytosis (HP:0001923)2.78178502
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.77958704
19Short 4th metacarpal (HP:0010044)2.77958704
20J-shaped sella turcica (HP:0002680)2.75487965
21Recurrent viral infections (HP:0004429)2.71345771
22Progressive external ophthalmoplegia (HP:0000590)2.54038857
23IgM deficiency (HP:0002850)2.52085181
24Malnutrition (HP:0004395)2.51358736
25Thin bony cortex (HP:0002753)2.50657732
26Sandal gap (HP:0001852)2.43691058
27Emphysema (HP:0002097)2.42326872
28Recurrent bronchitis (HP:0002837)2.41808881
29Glioma (HP:0009733)2.40553902
30Ragged-red muscle fibers (HP:0003200)2.39431218
31Cellulitis (HP:0100658)2.39161208
32High anterior hairline (HP:0009890)2.38929204
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.37307854
34Abnormality of cells of the lymphoid lineage (HP:0012140)2.36741971
35Cholecystitis (HP:0001082)2.35783453
36Abnormal gallbladder physiology (HP:0012438)2.35783453
37Prolonged bleeding time (HP:0003010)2.34877950
38Recurrent sinusitis (HP:0011108)2.33507005
39Spastic diplegia (HP:0001264)2.33295070
40Broad face (HP:0000283)2.33081640
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.32589449
42Abnormality of the aortic arch (HP:0012303)2.32333246
43Gastrointestinal stroma tumor (HP:0100723)2.31049027
44Hand muscle atrophy (HP:0009130)2.29034064
45Fatigue (HP:0012378)2.28893168
46Autoimmune thrombocytopenia (HP:0001973)2.27020225
47Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27011318
48Increased connective tissue (HP:0009025)2.25203739
49Papilloma (HP:0012740)2.24658920
50Verrucae (HP:0200043)2.24658920
51Medulloblastoma (HP:0002885)2.23564201
52Optic nerve coloboma (HP:0000588)2.23393433
53Viral hepatitis (HP:0006562)2.22632023
54Interstitial pulmonary disease (HP:0006530)2.22335860
55Panhypogammaglobulinemia (HP:0003139)2.20743117
56Abnormality of the thoracic spine (HP:0100711)2.18344551
57Eczematoid dermatitis (HP:0000976)2.18028402
58Distal lower limb amyotrophy (HP:0008944)2.18015726
59Lymphopenia (HP:0001888)2.17858159
60Seborrheic dermatitis (HP:0001051)2.17253190
61Colon cancer (HP:0003003)2.16426042
62Subacute progressive viral hepatitis (HP:0006572)2.14207820
63Pustule (HP:0200039)2.13429155
64Obsessive-compulsive behavior (HP:0000722)2.11381758
65Increased cerebral lipofuscin (HP:0011813)2.11308703
66Neoplasm of striated muscle (HP:0009728)2.08792070
67Dysostosis multiplex (HP:0000943)2.08494728
68Increased neuronal autofluorescent lipopigment (HP:0002074)2.08147536
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.07794626
70Selective tooth agenesis (HP:0001592)2.07309493
71Male infertility (HP:0003251)2.06725125
72Basal cell carcinoma (HP:0002671)2.05767335
73Metaphyseal cupping (HP:0003021)2.05632872
74Abnormal tarsal ossification (HP:0008369)2.01640211
75Neuronal loss in central nervous system (HP:0002529)2.01186948
76Menorrhagia (HP:0000132)2.00070368
77Microvesicular hepatic steatosis (HP:0001414)1.99515599
78Cervical subluxation (HP:0003308)1.98292593
79Nasal polyposis (HP:0100582)1.98267635
80Meningitis (HP:0001287)1.97446139
81Hyperacusis (HP:0010780)1.95979051
82Agnosia (HP:0010524)1.95294368
83Progressive muscle weakness (HP:0003323)1.95012943
84Asymmetry of the thorax (HP:0001555)1.94879235
85Abnormality of carpal bone ossification (HP:0006257)1.91948972
86Neoplasm of the heart (HP:0100544)1.91617152
87Cerebral aneurysm (HP:0004944)1.91386273
88Nuclear cataract (HP:0100018)1.91139818
89Leukopenia (HP:0001882)1.90850926
90Biliary tract neoplasm (HP:0100574)1.90294627
91Abdominal distention (HP:0003270)1.90056169
92Birth length less than 3rd percentile (HP:0003561)1.89797693
93Abnormality of small intestinal villus morphology (HP:0011472)1.89513528
94Villous atrophy (HP:0011473)1.89513528
95Distal upper limb amyotrophy (HP:0007149)1.89038195
96Upper limb amyotrophy (HP:0009129)1.89038195
97Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88311144
98Abnormality of polysaccharide metabolism (HP:0011012)1.88311144
99Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88311144
100Thrombocytosis (HP:0001894)1.87581555
101Abnormality of pyrimidine metabolism (HP:0004353)1.87570681
102Mucopolysacchariduria (HP:0008155)1.87282946
103Urinary glycosaminoglycan excretion (HP:0003541)1.87282946
104Restrictive lung disease (HP:0002091)1.85883312
105Recurrent fungal infections (HP:0002841)1.85428606
106Long palpebral fissure (HP:0000637)1.85194504
107Elevated alkaline phosphatase (HP:0003155)1.85113487
108Stridor (HP:0010307)1.84911654
109Obstructive sleep apnea (HP:0002870)1.84055026
110Gastrointestinal carcinoma (HP:0002672)1.83297215
111Malignant gastrointestinal tract tumors (HP:0006749)1.83297215
112B lymphocytopenia (HP:0010976)1.83056484
113Abnormality of B cell number (HP:0010975)1.83056484
114Cutis marmorata (HP:0000965)1.82692204
115IgA deficiency (HP:0002720)1.82671944
116Abnormality of the 4th metacarpal (HP:0010012)1.82231239
117Germ cell neoplasia (HP:0100728)1.82157346
118Abnormal foot bone ossification (HP:0010675)1.81332909
119Abnormality of reticulocytes (HP:0004312)1.81220833
120Aplastic anemia (HP:0001915)1.80387901
121Abnormality of sulfur amino acid metabolism (HP:0004339)1.80365910
122Angiofibromas (HP:0010615)1.79231219
123Adenoma sebaceum (HP:0009720)1.79231219
124Abnormality of T cell physiology (HP:0011840)1.78160932
125Abnormal enzyme/coenzyme activity (HP:0012379)1.77082932
126Hypertensive crisis (HP:0100735)1.76475057
127Increased serum ferritin (HP:0003281)1.76305714
128Chromsome breakage (HP:0040012)1.75747701
129Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75637056
130Abnormality of alkaline phosphatase activity (HP:0004379)1.75450873
131Increased IgE level (HP:0003212)1.75287942
132Hepatitis (HP:0012115)1.75168288
133External ophthalmoplegia (HP:0000544)1.75036894
134Loss of speech (HP:0002371)1.74795845
135Cafe-au-lait spot (HP:0000957)1.74466829
136Heterotopia (HP:0002282)1.73969239
137Prominent nose (HP:0000448)1.73185327
138Abnormality of macrophages (HP:0004311)1.72745315
139Renovascular hypertension (HP:0100817)1.72280304
140Lymphangioma (HP:0100764)1.70879146
141Abnormal hair laboratory examination (HP:0003328)1.70215838
142Abnormal ossification of hand bones (HP:0005921)1.69330400
143Epistaxis (HP:0000421)1.68167964
144Thoracic kyphosis (HP:0002942)1.67312515
145Micronodular cirrhosis (HP:0001413)1.67285135
146Persistence of primary teeth (HP:0006335)1.67218424
147Gastrointestinal dysmotility (HP:0002579)1.66701419
148Hypercortisolism (HP:0001578)1.66319167
149Purpura (HP:0000979)1.66243462
150Chromosomal breakage induced by crosslinking agents (HP:0003221)1.65762182
151Generalized hyperpigmentation (HP:0007440)1.65715946
152Skin tags (HP:0010609)1.65696046
153Advanced eruption of teeth (HP:0006288)1.65690450
154Abnormal biliary tract morphology (HP:0012440)1.65358581
155Dysmetric saccades (HP:0000641)1.63224228
156Combined immunodeficiency (HP:0005387)1.63078901
157Chronic mucocutaneous candidiasis (HP:0002728)1.62986227
158Recurrent cutaneous fungal infections (HP:0011370)1.62986227
159Overlapping toe (HP:0001845)1.62310793
160Abnormality of T cells (HP:0002843)1.62092664
161Down-sloping shoulders (HP:0200021)1.61663015
162Osteomyelitis (HP:0002754)1.61511584
163Limb hypertonia (HP:0002509)1.60235225
164Easy fatigability (HP:0003388)1.59789337
165Gingivitis (HP:0000230)1.59657377
166Recurrent otitis media (HP:0000403)1.59538328
167Nonimmune hydrops fetalis (HP:0001790)1.59341016
168Myelodysplasia (HP:0002863)1.58273301
169Syringomyelia (HP:0003396)1.58216933
170Spinal cord lesions (HP:0100561)1.58216933
171Flattened epiphyses (HP:0003071)1.57539710
172Hypobetalipoproteinemia (HP:0003563)1.56174845
173Patellar aplasia (HP:0006443)1.56001012
174Elfin facies (HP:0004428)1.55743544
175Thyroiditis (HP:0100646)1.55062502
176Hypoplasia of the thymus (HP:0000778)1.54448875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK36.12166006
2EEF2K4.32758737
3TAOK23.64402543
4MAP4K13.31034283
5MAP3K103.28562169
6SMG13.21429688
7NEK22.67013878
8ERN12.56241714
9LMTK22.49656549
10CDK122.39253132
11EPHB22.35269561
12TRIB32.32876370
13MST1R2.25018860
14BLK2.09869716
15STK101.97696140
16TYK21.96711039
17MAP2K61.93473546
18GRK61.88965814
19PRPF4B1.82387926
20CDC71.78860396
21PLK41.77318124
22RIPK11.61663399
23NEK11.60463478
24DYRK31.47465126
25NME21.43901193
26TTK1.42281679
27CSF1R1.39639505
28ACVR1B1.34809812
29CDK41.34759157
30NME11.34337391
31PTK61.32301198
32PKN21.32111619
33TNK21.30880701
34IRAK31.26290780
35SIK31.25710940
36SIK11.23865477
37SCYL21.20656551
38PIM21.19763995
39RIPK41.19038524
40RPS6KB21.15964172
41ZAP701.14998341
42PRKD21.11936165
43EPHB11.10034100
44BUB11.08181147
45STK41.07952964
46BRD41.04761092
47LRRK21.03633764
48PRKD31.03212849
49CDK61.02292040
50ATR1.02285079
51MAP3K81.00686922
52MELK1.00345182
53ICK0.94302298
54CDC42BPA0.94104670
55MTOR0.92855081
56SYK0.92686425
57SIK20.91151473
58PLK10.89900519
59MAP3K50.89703105
60RPS6KA20.88968608
61BTK0.87921464
62MAP3K110.85950463
63RET0.85878715
64IRAK40.84389192
65ALK0.84084632
66MET0.83132251
67CHEK10.81834888
68BMX0.79659961
69JAK10.78282030
70EPHA20.76893249
71PDGFRA0.72190254
72TRPM70.71702567
73TESK20.70876023
74FGFR30.70447180
75CAMK1D0.70190970
76TAOK30.70054076
77ERBB20.69526773
78MAP3K70.69354457
79KIT0.69210080
80MAP2K30.68754611
81RPS6KA40.67334852
82AURKB0.66334999
83MAPK110.65004097
84TTN0.64578149
85CDK20.63799440
86HCK0.63275605
87RPS6KC10.62749689
88RPS6KL10.62749689
89JAK30.62114620
90PAK40.61913334
91DYRK1B0.61896185
92MAP3K30.60487735
93EIF2AK30.56649859
94MAP3K10.56570043
95MARK20.55683498
96PTK20.54837442
97MAP3K130.54127978
98CHUK0.52717108
99STK30.52706452
100DDR20.52489329
101BRSK10.52323827
102CDK90.51983364
103TESK10.51798944
104MAPKAPK30.50886128
105WEE10.49570368
106NEK60.49538838
107TLK10.48245559
108FGFR40.48089852
109CHEK20.47397634
110PDK10.46339223
111MAP3K60.45595710
112CDK70.45135287
113IKBKE0.44970530
114RPS6KA60.42799647
115HIPK20.42717401
116PIM10.42193597
117MAP2K20.41827545
118PRKCI0.41073485
119KSR20.40517907
120PRKCH0.39997313
121ATM0.39796144
122RPS6KB10.38346174
123TAOK10.38252691
124LYN0.38060233
125PRKAA10.37974005
126CLK10.37226222
127JAK20.36630172
128MAP3K140.36404701
129PASK0.35431086
130KDR0.35083662
131CDK10.34451819
132PRKAA20.32851310
133MAPKAPK20.32526434
134TBK10.32392297
135FLT30.31761292
136TSSK60.31757687
137MAPK120.31375453
138STK380.30961770
139AKT20.30949275
140FGR0.30269431
141MATK0.30118244
142FRK0.29099597
143BRAF0.29041734
144CSNK1A1L0.28014236
145BCKDK0.26799699
146PDPK10.26616660

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.11836028
2DNA replication_Homo sapiens_hsa030302.69182882
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.66585739
4One carbon pool by folate_Homo sapiens_hsa006702.55790647
5Mismatch repair_Homo sapiens_hsa034302.38010440
6B cell receptor signaling pathway_Homo sapiens_hsa046622.37681512
7Primary immunodeficiency_Homo sapiens_hsa053402.37392527
8Base excision repair_Homo sapiens_hsa034102.30934278
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.91366614
10Lysine degradation_Homo sapiens_hsa003101.87377337
11Cell cycle_Homo sapiens_hsa041101.63848565
12Bladder cancer_Homo sapiens_hsa052191.59328960
13Selenocompound metabolism_Homo sapiens_hsa004501.57783925
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.43285702
15VEGF signaling pathway_Homo sapiens_hsa043701.41727715
16Pentose phosphate pathway_Homo sapiens_hsa000301.38003936
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33102063
18RNA transport_Homo sapiens_hsa030131.32806023
19Fatty acid degradation_Homo sapiens_hsa000711.31761168
20Fanconi anemia pathway_Homo sapiens_hsa034601.29493471
21mTOR signaling pathway_Homo sapiens_hsa041501.26618631
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26242755
23Nitrogen metabolism_Homo sapiens_hsa009101.26006243
24Insulin signaling pathway_Homo sapiens_hsa049101.24825448
25Homologous recombination_Homo sapiens_hsa034401.24135243
26Antigen processing and presentation_Homo sapiens_hsa046121.21688164
27Fat digestion and absorption_Homo sapiens_hsa049751.21323362
28ErbB signaling pathway_Homo sapiens_hsa040121.21057714
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18517542
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18333178
31Chronic myeloid leukemia_Homo sapiens_hsa052201.18299884
32Choline metabolism in cancer_Homo sapiens_hsa052311.17384382
33Endometrial cancer_Homo sapiens_hsa052131.14457875
34Spliceosome_Homo sapiens_hsa030401.14438581
35ABC transporters_Homo sapiens_hsa020101.12485464
36Acute myeloid leukemia_Homo sapiens_hsa052211.10641035
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10470605
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09378052
39Non-small cell lung cancer_Homo sapiens_hsa052231.09323775
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.09037511
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08676296
42Sulfur relay system_Homo sapiens_hsa041221.06680188
43Glioma_Homo sapiens_hsa052141.04566566
44Biosynthesis of amino acids_Homo sapiens_hsa012301.00626517
45Herpes simplex infection_Homo sapiens_hsa051681.00323050
46Thyroid cancer_Homo sapiens_hsa052161.00142943
47Folate biosynthesis_Homo sapiens_hsa007900.98980199
48Non-homologous end-joining_Homo sapiens_hsa034500.98826882
49Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98018987
50Renin-angiotensin system_Homo sapiens_hsa046140.97178514
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.96871468
52Fatty acid biosynthesis_Homo sapiens_hsa000610.95803313
53Glycerophospholipid metabolism_Homo sapiens_hsa005640.95343296
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95175997
55Caffeine metabolism_Homo sapiens_hsa002320.95054017
56Lysosome_Homo sapiens_hsa041420.93800984
57p53 signaling pathway_Homo sapiens_hsa041150.92565754
58mRNA surveillance pathway_Homo sapiens_hsa030150.92493112
59Prostate cancer_Homo sapiens_hsa052150.92448497
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91255772
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.90641649
62Influenza A_Homo sapiens_hsa051640.89756564
63Apoptosis_Homo sapiens_hsa042100.88443261
64Insulin resistance_Homo sapiens_hsa049310.88151631
65Arginine biosynthesis_Homo sapiens_hsa002200.87511912
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.86914496
67Vitamin B6 metabolism_Homo sapiens_hsa007500.86155217
68Tryptophan metabolism_Homo sapiens_hsa003800.81875984
69Phenylalanine metabolism_Homo sapiens_hsa003600.81377194
70Renal cell carcinoma_Homo sapiens_hsa052110.80691207
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.79426176
72GnRH signaling pathway_Homo sapiens_hsa049120.78209915
73Galactose metabolism_Homo sapiens_hsa000520.78054650
74HIF-1 signaling pathway_Homo sapiens_hsa040660.77697736
75Leishmaniasis_Homo sapiens_hsa051400.77463199
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.77438224
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76368404
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76232582
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76103976
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75690572
81Prolactin signaling pathway_Homo sapiens_hsa049170.75268416
82PPAR signaling pathway_Homo sapiens_hsa033200.75047744
83Fatty acid metabolism_Homo sapiens_hsa012120.73344145
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.73246013
85Viral carcinogenesis_Homo sapiens_hsa052030.72763210
86Osteoclast differentiation_Homo sapiens_hsa043800.71474915
87Epstein-Barr virus infection_Homo sapiens_hsa051690.70610902
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69664776
89Sphingolipid metabolism_Homo sapiens_hsa006000.67635594
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67417333
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66997411
92Small cell lung cancer_Homo sapiens_hsa052220.66455772
93Measles_Homo sapiens_hsa051620.66083611
94Hepatitis C_Homo sapiens_hsa051600.66002947
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65450578
96Inositol phosphate metabolism_Homo sapiens_hsa005620.65362980
97Colorectal cancer_Homo sapiens_hsa052100.65155688
98Fructose and mannose metabolism_Homo sapiens_hsa000510.64957697
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64795622
100Nucleotide excision repair_Homo sapiens_hsa034200.64445969
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63937267
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.63130749
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.62507023
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62160927
105Glucagon signaling pathway_Homo sapiens_hsa049220.61501128
106Notch signaling pathway_Homo sapiens_hsa043300.61216121
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.60692468
108T cell receptor signaling pathway_Homo sapiens_hsa046600.60611978
109HTLV-I infection_Homo sapiens_hsa051660.60223714
110Tuberculosis_Homo sapiens_hsa051520.59851921
111Endocytosis_Homo sapiens_hsa041440.59194855
112Pancreatic cancer_Homo sapiens_hsa052120.59012499
113MicroRNAs in cancer_Homo sapiens_hsa052060.58908045
114Systemic lupus erythematosus_Homo sapiens_hsa053220.58841723
1152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58306897
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57573762
117TNF signaling pathway_Homo sapiens_hsa046680.56880775
118AMPK signaling pathway_Homo sapiens_hsa041520.56864458
119Glycerolipid metabolism_Homo sapiens_hsa005610.56603955
120Carbon metabolism_Homo sapiens_hsa012000.55651465
121N-Glycan biosynthesis_Homo sapiens_hsa005100.55355164
122Vitamin digestion and absorption_Homo sapiens_hsa049770.54796712
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54231751
124Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.54145394
125Staphylococcus aureus infection_Homo sapiens_hsa051500.54044709
126Toxoplasmosis_Homo sapiens_hsa051450.53695561
127Hepatitis B_Homo sapiens_hsa051610.53654225
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53196370
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52371393
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51908085
131Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51832778
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.51666091
133Pyrimidine metabolism_Homo sapiens_hsa002400.51423231
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49362676
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.49253411
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48247429
137Complement and coagulation cascades_Homo sapiens_hsa046100.47973454
138Estrogen signaling pathway_Homo sapiens_hsa049150.46768143
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.46474202
140FoxO signaling pathway_Homo sapiens_hsa040680.42559426
141Proteoglycans in cancer_Homo sapiens_hsa052050.39828327
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38062305

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