REEP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial protein that functions to enhance the cell surface expression of odorant receptors. Mutations in this gene cause spastic paraplegia autosomal dominant type 31, a neurodegenerative disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42551635
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08242899
3synaptic vesicle maturation (GO:0016188)5.02697006
4synaptic vesicle exocytosis (GO:0016079)4.98561667
5neuron cell-cell adhesion (GO:0007158)4.96028864
6layer formation in cerebral cortex (GO:0021819)4.88942139
7presynaptic membrane assembly (GO:0097105)4.87980968
8vocalization behavior (GO:0071625)4.84200493
9protein localization to synapse (GO:0035418)4.79599917
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.69752980
11pyrimidine nucleobase catabolic process (GO:0006208)4.64086736
12glutamate secretion (GO:0014047)4.63750997
13regulation of synaptic vesicle exocytosis (GO:2000300)4.59970191
14locomotory exploration behavior (GO:0035641)4.54004350
15negative regulation of synaptic transmission, GABAergic (GO:0032229)4.49188165
16cell migration in hindbrain (GO:0021535)4.47424929
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45631352
18presynaptic membrane organization (GO:0097090)4.45184264
19regulation of glutamate receptor signaling pathway (GO:1900449)4.26435258
20exploration behavior (GO:0035640)4.25825469
21regulation of synapse structural plasticity (GO:0051823)4.24462366
22negative regulation of microtubule polymerization (GO:0031115)4.08827069
23proline transport (GO:0015824)4.08580464
24regulation of synaptic vesicle transport (GO:1902803)4.05197915
25neurotransmitter secretion (GO:0007269)4.02158065
26synaptic vesicle docking involved in exocytosis (GO:0016081)4.00562009
27neuron recognition (GO:0008038)4.00343135
28axonal fasciculation (GO:0007413)3.77324947
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.76605797
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.76100289
31positive regulation of synapse maturation (GO:0090129)3.74288254
32nucleobase catabolic process (GO:0046113)3.74174805
33dendritic spine morphogenesis (GO:0060997)3.72500335
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71870175
35dendrite morphogenesis (GO:0048813)3.70672286
36neuronal action potential propagation (GO:0019227)3.63527840
37regulation of neuronal synaptic plasticity (GO:0048168)3.61657268
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53035039
39positive regulation of synapse assembly (GO:0051965)3.51206243
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.50780049
41glutamate receptor signaling pathway (GO:0007215)3.47158133
42synaptic transmission, glutamatergic (GO:0035249)3.44770902
43epithelial cell differentiation involved in kidney development (GO:0035850)3.44027116
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.43753846
45mitochondrion transport along microtubule (GO:0047497)3.43753846
46innervation (GO:0060384)3.43516831
47neurotransmitter-gated ion channel clustering (GO:0072578)3.42154162
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41223328
49glycosphingolipid biosynthetic process (GO:0006688)3.40763007
50activation of protein kinase A activity (GO:0034199)3.39463848
51neuron-neuron synaptic transmission (GO:0007270)3.39391183
52cellular potassium ion homeostasis (GO:0030007)3.37835505
53postsynaptic membrane organization (GO:0001941)3.36219998
54establishment of mitochondrion localization (GO:0051654)3.35608687
55membrane depolarization during action potential (GO:0086010)3.33653585
56organelle transport along microtubule (GO:0072384)3.32920421
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.30763650
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.30154199
59neurotransmitter transport (GO:0006836)3.24828675
60axon cargo transport (GO:0008088)3.24390572
61neurofilament cytoskeleton organization (GO:0060052)3.21689893
62synapse assembly (GO:0007416)3.20515187
63cell communication by electrical coupling (GO:0010644)3.19018044
64startle response (GO:0001964)3.17790649
65regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17336810
66central nervous system projection neuron axonogenesis (GO:0021952)3.16377214
67positive regulation of synaptic transmission, GABAergic (GO:0032230)3.16320048
68axon extension (GO:0048675)3.16319175
69behavioral response to nicotine (GO:0035095)3.15639935
70vesicle transport along microtubule (GO:0047496)3.14579050
71gamma-aminobutyric acid transport (GO:0015812)3.13735767
72prepulse inhibition (GO:0060134)3.13535726
73cerebral cortex radially oriented cell migration (GO:0021799)3.13493363
74positive regulation of potassium ion transmembrane transport (GO:1901381)3.11075096
75auditory behavior (GO:0031223)3.10829331
76sodium ion export (GO:0071436)3.10659199
77regulation of neurotransmitter secretion (GO:0046928)3.09036826
78regulation of action potential (GO:0098900)3.07343443
79cerebellar Purkinje cell differentiation (GO:0021702)3.06281547
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.06005989
81synaptic vesicle endocytosis (GO:0048488)3.04468774
82neuromuscular process controlling balance (GO:0050885)3.03998992
83positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.02869229
84regulation of synapse assembly (GO:0051963)3.02809588
85regulation of dendritic spine morphogenesis (GO:0061001)3.01518346
86regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01293318
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00998427
88mechanosensory behavior (GO:0007638)3.00907386
89response to auditory stimulus (GO:0010996)3.00510584
90regulation of vesicle fusion (GO:0031338)3.00457687
91regulation of synaptic transmission, glutamatergic (GO:0051966)2.99742358
92regulation of cAMP-dependent protein kinase activity (GO:2000479)2.99692081
93regulation of postsynaptic membrane potential (GO:0060078)2.99046967
94regulation of feeding behavior (GO:0060259)2.98832967
95dopamine receptor signaling pathway (GO:0007212)2.98346260
96regulation of neurotransmitter levels (GO:0001505)2.98149686
97transmission of nerve impulse (GO:0019226)2.97377745
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96350058
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.95657530
100mating behavior (GO:0007617)2.93100678
101positive regulation of membrane potential (GO:0045838)2.92189565
102neuromuscular synaptic transmission (GO:0007274)2.91900187
103hippocampus development (GO:0021766)2.91774585
104long-term memory (GO:0007616)2.91268276
105C4-dicarboxylate transport (GO:0015740)2.90637378
106neuronal action potential (GO:0019228)2.89243036
107calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.88232369
108membrane hyperpolarization (GO:0060081)2.88107271
109clathrin coat assembly (GO:0048268)2.87892312
110neuron projection extension (GO:1990138)2.87787164
111protein localization to cilium (GO:0061512)2.87772993
112adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.87188050
113membrane depolarization (GO:0051899)2.86870130
114negative regulation of dendrite development (GO:2000171)2.86741351
115response to histamine (GO:0034776)2.86426802
116regulation of synaptic plasticity (GO:0048167)2.86422707
117regulation of synapse maturation (GO:0090128)2.86265290
118positive regulation of mitochondrial fission (GO:0090141)2.86121557
119negative regulation of dendrite morphogenesis (GO:0050774)2.85800814
120synapse organization (GO:0050808)2.85314454
121regulation of neurotransmitter transport (GO:0051588)2.85066867
122positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81890818
123response to dietary excess (GO:0002021)2.79948867
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.79920270
125positive regulation of action potential (GO:0045760)2.77974869
126short-term memory (GO:0007614)2.77257879
127substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.73815912
128substrate-independent telencephalic tangential migration (GO:0021826)2.73815912
129regulation of sarcomere organization (GO:0060297)2.72621160
130positive regulation of amino acid transport (GO:0051957)2.66511425
131regulation of synaptic transmission, GABAergic (GO:0032228)2.64524799
132regulation of membrane repolarization (GO:0060306)2.64384305
133adult walking behavior (GO:0007628)2.63972565
134regulation of synapse organization (GO:0050807)2.60967069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.98571704
2GBX2_23144817_ChIP-Seq_PC3_Human3.35903871
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07858134
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05511040
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89345160
6REST_21632747_ChIP-Seq_MESCs_Mouse2.81594865
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.69567909
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68952847
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68952847
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.68022576
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64382604
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46718058
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46043477
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42975912
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42499201
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42039104
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.33925285
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.29459994
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.28381586
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24988362
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.23546119
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.17650815
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.16111189
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13270166
25DROSHA_22980978_ChIP-Seq_HELA_Human2.11791627
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.98086343
27TAF15_26573619_Chip-Seq_HEK293_Human1.94569939
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94293966
29VDR_22108803_ChIP-Seq_LS180_Human1.90477910
30AR_21572438_ChIP-Seq_LNCaP_Human1.84726097
31ZNF274_21170338_ChIP-Seq_K562_Hela1.80638323
32EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78949055
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.76193342
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73308609
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69335084
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.68064416
37SMAD4_21799915_ChIP-Seq_A2780_Human1.57741654
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57506324
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.50882681
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50466437
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47467442
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.45225104
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45150068
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43455796
45IGF1R_20145208_ChIP-Seq_DFB_Human1.42552045
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.41783755
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40894116
48EWS_26573619_Chip-Seq_HEK293_Human1.40231318
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40086708
50* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36851212
51RNF2_27304074_Chip-Seq_NSC_Mouse1.36150487
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35543850
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33801554
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33733021
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32800499
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31282881
57P300_19829295_ChIP-Seq_ESCs_Human1.28980864
58FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.28098255
59ER_23166858_ChIP-Seq_MCF-7_Human1.26735285
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25868437
61CBP_20019798_ChIP-Seq_JUKART_Human1.25253588
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25253588
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22570220
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.22543702
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.22231230
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21746442
67AR_25329375_ChIP-Seq_VCAP_Human1.20718996
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20479045
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19125622
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.17490312
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16782733
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16270423
73AR_19668381_ChIP-Seq_PC3_Human1.15846227
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.14105566
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13822965
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13448738
77* STAT3_23295773_ChIP-Seq_U87_Human1.13080975
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.12886764
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.12400503
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10756405
81FLI1_27457419_Chip-Seq_LIVER_Mouse1.10548558
82KDM2B_26808549_Chip-Seq_K562_Human1.09615509
83* TAL1_26923725_Chip-Seq_HPCs_Mouse1.09497524
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08968809
85* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08904403
86AHR_22903824_ChIP-Seq_MCF-7_Human1.08362216
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07587586
88* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07450957
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07047789
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.06570920
91BCAT_22108803_ChIP-Seq_LS180_Human1.05086067
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04827965
93* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02640417
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01824276
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01583442
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00880689
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.00765992
98* SMAD3_21741376_ChIP-Seq_ESCs_Human1.00025997
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99883959
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99024135
101CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98624998
102* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.98484440
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98118793
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97886154
105TCF4_23295773_ChIP-Seq_U87_Human0.97334854
106KDM2B_26808549_Chip-Seq_REH_Human0.96017500
107MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95623067
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.95061877
109JUN_21703547_ChIP-Seq_K562_Human0.94976634
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94943545
111P53_22387025_ChIP-Seq_ESCs_Mouse0.94004792
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.93797351
113CTCF_27219007_Chip-Seq_Bcells_Human0.93234359
114PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92877474
115POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92552051
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91883584
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91883584
118RUNX2_22187159_ChIP-Seq_PCA_Human0.91684377
119OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91329943
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.90770832
121ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90413108
122* TET1_21490601_ChIP-Seq_MESCs_Mouse0.89003407
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85826068
124NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85080837
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84796597
126FUS_26573619_Chip-Seq_HEK293_Human0.84000548

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.25326725
2MP0004270_analgesia4.34878888
3MP0003880_abnormal_central_pattern4.07643897
4MP0003635_abnormal_synaptic_transmissio3.61805755
5MP0001968_abnormal_touch/_nociception3.48801063
6MP0002735_abnormal_chemical_nociception3.33930944
7MP0002734_abnormal_mechanical_nocicepti3.06667962
8MP0005423_abnormal_somatic_nervous3.02906341
9MP0002063_abnormal_learning/memory/cond2.99991826
10MP0006276_abnormal_autonomic_nervous2.84362863
11MP0009745_abnormal_behavioral_response2.79441716
12MP0002736_abnormal_nociception_after2.75983054
13MP0002733_abnormal_thermal_nociception2.60342464
14MP0009046_muscle_twitch2.57718184
15MP0002064_seizures2.57363701
16MP0002572_abnormal_emotion/affect_behav2.46374652
17MP0004858_abnormal_nervous_system2.45025658
18MP0000778_abnormal_nervous_system2.34318767
19MP0002184_abnormal_innervation2.32502845
20MP0001970_abnormal_pain_threshold2.27268657
21MP0002272_abnormal_nervous_system2.26332493
22MP0002822_catalepsy2.22842964
23MP0001486_abnormal_startle_reflex2.17185843
24MP0001440_abnormal_grooming_behavior2.15276753
25MP0002067_abnormal_sensory_capabilities1.99903645
26MP0004811_abnormal_neuron_physiology1.92280524
27MP0003329_amyloid_beta_deposits1.92255523
28MP0002557_abnormal_social/conspecific_i1.75711134
29MP0004924_abnormal_behavior1.75627289
30MP0005386_behavior/neurological_phenoty1.75627289
31MP0001984_abnormal_olfaction1.75021726
32MP0000955_abnormal_spinal_cord1.74519151
33MP0001501_abnormal_sleep_pattern1.72837756
34MP0000751_myopathy1.64037891
35MP0009780_abnormal_chondrocyte_physiolo1.52419101
36MP0002909_abnormal_adrenal_gland1.51855398
37MP0002882_abnormal_neuron_morphology1.51187476
38MP0003879_abnormal_hair_cell1.44820276
39MP0003122_maternal_imprinting1.44191171
40MP0001529_abnormal_vocalization1.41610611
41MP0008569_lethality_at_weaning1.40386327
42MP0000569_abnormal_digit_pigmentation1.38237616
43MP0002066_abnormal_motor_capabilities/c1.34019435
44MP0001905_abnormal_dopamine_level1.32421048
45MP0005645_abnormal_hypothalamus_physiol1.29793649
46MP0008877_abnormal_DNA_methylation1.29768798
47MP0001188_hyperpigmentation1.25762485
48MP0004145_abnormal_muscle_electrophysio1.20499945
49MP0004885_abnormal_endolymph1.18336882
50MP0002152_abnormal_brain_morphology1.17684349
51MP0004142_abnormal_muscle_tone1.16279163
52MP0004133_heterotaxia1.08189616
53MP0001502_abnormal_circadian_rhythm1.07439227
54MP0002234_abnormal_pharynx_morphology1.04867453
55MP0005646_abnormal_pituitary_gland1.03939613
56MP0003787_abnormal_imprinting1.02301950
57MP0002751_abnormal_autonomic_nervous1.01774941
58MP0002752_abnormal_somatic_nervous0.95580344
59MP0003633_abnormal_nervous_system0.95518636
60MP0005187_abnormal_penis_morphology0.94038241
61MP0002653_abnormal_ependyma_morphology0.93491302
62MP0000049_abnormal_middle_ear0.93486409
63MP0005499_abnormal_olfactory_system0.92075123
64MP0005394_taste/olfaction_phenotype0.92075123
65MP0004742_abnormal_vestibular_system0.91792260
66MP0002229_neurodegeneration0.91397678
67MP0003631_nervous_system_phenotype0.91289679
68MP0003634_abnormal_glial_cell0.91209916
69MP0000631_abnormal_neuroendocrine_gland0.90839700
70MP0000013_abnormal_adipose_tissue0.87944732
71MP0002837_dystrophic_cardiac_calcinosis0.87466165
72MP0005253_abnormal_eye_physiology0.87294379
73MP0008995_early_reproductive_senescence0.86631149
74MP0003221_abnormal_cardiomyocyte_apopto0.86289258
75MP0002102_abnormal_ear_morphology0.85742073
76MP0004233_abnormal_muscle_weight0.85550716
77MP0003861_abnormal_nervous_system0.84959672
78MP0004085_abnormal_heartbeat0.84815097
79MP0004043_abnormal_pH_regulation0.83658227
80MP0004215_abnormal_myocardial_fiber0.83407695
81MP0003938_abnormal_ear_development0.82144584
82MP0000026_abnormal_inner_ear0.80608695
83MP0002069_abnormal_eating/drinking_beha0.80540137
84MP0003119_abnormal_digestive_system0.78189382
85MP0001299_abnormal_eye_distance/0.76233294
86MP0003137_abnormal_impulse_conducting0.75966325
87MP0000604_amyloidosis0.73710961
88MP0003632_abnormal_nervous_system0.73520315
89MP0010386_abnormal_urinary_bladder0.73138161
90MP0002332_abnormal_exercise_endurance0.72934905
91MP0000534_abnormal_ureter_morphology0.72828126
92MP0001963_abnormal_hearing_physiology0.72630315
93MP0008872_abnormal_physiological_respon0.71340885
94MP0000750_abnormal_muscle_regeneration0.69855230
95MP0006072_abnormal_retinal_apoptosis0.68915397
96MP0005623_abnormal_meninges_morphology0.68820338
97MP0005551_abnormal_eye_electrophysiolog0.68488686
98MP0001348_abnormal_lacrimal_gland0.67828559
99MP0001485_abnormal_pinna_reflex0.67343923
100MP0003890_abnormal_embryonic-extraembry0.67177313
101MP0000747_muscle_weakness0.66243460
102MP0002638_abnormal_pupillary_reflex0.65549506
103MP0008961_abnormal_basal_metabolism0.65415210
104MP0006035_abnormal_mitochondrial_morpho0.64374881
105MP0003646_muscle_fatigue0.64192455
106MP0005535_abnormal_body_temperature0.58020292
107MP0001986_abnormal_taste_sensitivity0.57814726
108MP0004484_altered_response_of0.57389172
109MP0001943_abnormal_respiration0.56847151
110MP0001177_atelectasis0.56453694
111MP0003121_genomic_imprinting0.55512604
112MP0000537_abnormal_urethra_morphology0.54823311
113MP0010769_abnormal_survival0.54222396
114MP0010770_preweaning_lethality0.54159447
115MP0002082_postnatal_lethality0.54159447
116MP0005620_abnormal_muscle_contractility0.53441929
117MP0009379_abnormal_foot_pigmentation0.52755759
118MP0008789_abnormal_olfactory_epithelium0.52129420
119MP0002090_abnormal_vision0.52034541

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.14296966
2Focal motor seizures (HP:0011153)5.31068146
3Focal seizures (HP:0007359)4.76406349
4Visual hallucinations (HP:0002367)4.47293768
5Progressive cerebellar ataxia (HP:0002073)3.89008308
6Epileptic encephalopathy (HP:0200134)3.68384786
7Action tremor (HP:0002345)3.67992556
8Mutism (HP:0002300)3.65668455
9Supranuclear gaze palsy (HP:0000605)3.61161139
10Atonic seizures (HP:0010819)3.59842727
11Limb dystonia (HP:0002451)3.57857031
12Insidious onset (HP:0003587)3.41170744
13Termporal pattern (HP:0011008)3.41170744
14Absence seizures (HP:0002121)3.38752855
15Febrile seizures (HP:0002373)3.37454013
16Amyotrophic lateral sclerosis (HP:0007354)3.22223182
17Generalized tonic-clonic seizures (HP:0002069)3.20328709
18Pheochromocytoma (HP:0002666)3.16125278
19Absent speech (HP:0001344)3.07737155
20Dialeptic seizures (HP:0011146)3.03114519
21Broad-based gait (HP:0002136)3.02698732
22Polyphagia (HP:0002591)2.98242261
23Fetal akinesia sequence (HP:0001989)2.94308503
24Retinal dysplasia (HP:0007973)2.90440717
25Urinary bladder sphincter dysfunction (HP:0002839)2.87390636
26Abnormality of the corticospinal tract (HP:0002492)2.86636090
27Ulnar claw (HP:0001178)2.86578005
28Amblyopia (HP:0000646)2.86435010
29Medial flaring of the eyebrow (HP:0010747)2.84528960
30Abnormality of the lower motor neuron (HP:0002366)2.84485475
31* Ankle clonus (HP:0011448)2.84318764
32Progressive inability to walk (HP:0002505)2.78373459
33Depression (HP:0000716)2.77567190
34Abnormal eating behavior (HP:0100738)2.75156812
35Neuroendocrine neoplasm (HP:0100634)2.73416266
36Excessive salivation (HP:0003781)2.70726059
37Drooling (HP:0002307)2.70726059
38Congenital primary aphakia (HP:0007707)2.68834028
39Truncal ataxia (HP:0002078)2.67954959
40Spastic tetraplegia (HP:0002510)2.64480486
41Poor eye contact (HP:0000817)2.62944916
42Impaired vibration sensation in the lower limbs (HP:0002166)2.62506286
43Nephrogenic diabetes insipidus (HP:0009806)2.61755695
44Cortical dysplasia (HP:0002539)2.58288750
45Akinesia (HP:0002304)2.58234559
46Torticollis (HP:0000473)2.56808635
47Hypoplasia of the brainstem (HP:0002365)2.56607404
48Aplasia/Hypoplasia of the brainstem (HP:0007362)2.56607404
49Shoulder girdle muscle weakness (HP:0003547)2.53957545
50Poor suck (HP:0002033)2.49839224
51Failure to thrive in infancy (HP:0001531)2.41228561
52Abnormal social behavior (HP:0012433)2.41030464
53Impaired social interactions (HP:0000735)2.41030464
54Type II lissencephaly (HP:0007260)2.40123734
55Abnormality of the labia minora (HP:0012880)2.38691122
56Genital tract atresia (HP:0001827)2.37597188
57Epileptiform EEG discharges (HP:0011182)2.37369232
58EEG with generalized epileptiform discharges (HP:0011198)2.37188994
59Cerebral inclusion bodies (HP:0100314)2.36485399
60Hyperventilation (HP:0002883)2.34117912
61Papilledema (HP:0001085)2.33328972
62Genetic anticipation (HP:0003743)2.33154523
63* Urinary urgency (HP:0000012)2.31840133
64Ventricular fibrillation (HP:0001663)2.31776339
65Vaginal atresia (HP:0000148)2.31560964
66Anxiety (HP:0000739)2.30773723
67Split foot (HP:0001839)2.29987617
68Hypsarrhythmia (HP:0002521)2.28412811
69Agitation (HP:0000713)2.28203511
70Esotropia (HP:0000565)2.26017994
71Neurofibrillary tangles (HP:0002185)2.23448841
72Hypoventilation (HP:0002791)2.23382376
73Dysdiadochokinesis (HP:0002075)2.23096220
74Degeneration of the lateral corticospinal tracts (HP:0002314)2.22158892
75Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.22158892
76Hepatoblastoma (HP:0002884)2.21467880
77Abnormality of pain sensation (HP:0010832)2.21184213
78Impaired pain sensation (HP:0007328)2.21184213
79Hemiparesis (HP:0001269)2.17731534
80Gaze-evoked nystagmus (HP:0000640)2.16737373
81Focal dystonia (HP:0004373)2.16444749
82Inability to walk (HP:0002540)2.16069827
83Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.15114258
84Morphological abnormality of the pyramidal tract (HP:0002062)2.13793164
85Postural instability (HP:0002172)2.11114117
86Neoplasm of the adrenal cortex (HP:0100641)2.10551379
87Hypothermia (HP:0002045)2.09466474
88Muscular hypotonia of the trunk (HP:0008936)2.08916229
89Craniofacial dystonia (HP:0012179)2.08767057
90* Spastic gait (HP:0002064)2.07678874
91Apathy (HP:0000741)2.07255141
92Neoplasm of the peripheral nervous system (HP:0100007)2.06728833
93Inappropriate behavior (HP:0000719)2.05673824
94Lissencephaly (HP:0001339)2.05646183
95Bradykinesia (HP:0002067)2.05580294
96Abnormality of salivation (HP:0100755)2.05419091
97Intention tremor (HP:0002080)2.04994845
98Dysmetria (HP:0001310)2.04932249
99Gait imbalance (HP:0002141)2.03031896
100Renal cortical cysts (HP:0000803)2.00508899
101Insomnia (HP:0100785)1.99288561
102Abnormality of the vocal cords (HP:0008777)1.99008193
103True hermaphroditism (HP:0010459)1.97789997
104Status epilepticus (HP:0002133)1.97709895
105Generalized myoclonic seizures (HP:0002123)1.96593682
106Hypoplasia of the corpus callosum (HP:0002079)1.96440979
107Exotropia (HP:0000577)1.96119750
108Diplopia (HP:0000651)1.94762507
109Abnormality of binocular vision (HP:0011514)1.94762507
110Calf muscle hypertrophy (HP:0008981)1.93698079
111Megalencephaly (HP:0001355)1.92969632
112Intellectual disability, severe (HP:0010864)1.92721859
113Pointed chin (HP:0000307)1.89813603
114Specific learning disability (HP:0001328)1.89229959
115Hammertoe (HP:0001765)1.89161229
116Molar tooth sign on MRI (HP:0002419)1.87900046
117Abnormality of midbrain morphology (HP:0002418)1.87900046
118Stereotypic behavior (HP:0000733)1.86456806
119Aqueductal stenosis (HP:0002410)1.86185239
120Protruding tongue (HP:0010808)1.86007729
121Dyskinesia (HP:0100660)1.85246869
122Abnormality of the musculature of the pelvis (HP:0001469)1.83814019
123Abnormality of the hip-girdle musculature (HP:0001445)1.83814019
124* Lower limb muscle weakness (HP:0007340)1.83554682
125Diminished motivation (HP:0000745)1.83021010
126Pachygyria (HP:0001302)1.81765196
127Myotonia (HP:0002486)1.81268873
128Impaired smooth pursuit (HP:0007772)1.81044365
129Pendular nystagmus (HP:0012043)1.80884351
130Poor coordination (HP:0002370)1.80075253
131Lower limb amyotrophy (HP:0007210)1.80066648
132Lower limb asymmetry (HP:0100559)1.79761762
133Delusions (HP:0000746)1.79545417
134Exercise-induced myalgia (HP:0003738)1.79499939
135Nephronophthisis (HP:0000090)1.78830561
136Pancreatic fibrosis (HP:0100732)1.77444043
137Polymicrogyria (HP:0002126)1.76964025
138Atrophy/Degeneration involving motor neurons (HP:0007373)1.76955995
139Rimmed vacuoles (HP:0003805)1.76803872
140Muscle hypertrophy of the lower extremities (HP:0008968)1.75151674
141Pancreatic cysts (HP:0001737)1.71421555
142Delayed gross motor development (HP:0002194)1.69287966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.70308770
2MAP3K93.80687188
3NTRK33.63576892
4MINK13.19211942
5MAP3K43.01216943
6MAP4K22.74131013
7MAP2K72.44633422
8TRIM282.37682673
9PHKG12.31032657
10PHKG22.31032657
11EPHA42.30176234
12NTRK22.19558891
13MAP3K122.12682398
14DAPK22.06282336
15PAK62.04121515
16MAPK131.96635718
17CASK1.96115184
18NTRK11.88476818
19PNCK1.88270690
20MAP2K41.86362328
21LATS21.85963025
22KSR21.83873966
23KSR11.72842595
24DYRK21.54652257
25EPHA31.49663085
26CDK51.41711527
27GRK51.34855444
28LIMK11.34596797
29SIK21.31166805
30LMTK21.30727265
31PLK21.29960446
32CAMKK11.29239710
33PRKD31.26824962
34CSNK1G21.21751164
35TYRO31.13490292
36DAPK11.13449526
37MAP3K21.13341582
38PRKCG1.10961125
39ERBB31.08684274
40FRK1.08147804
41MAP3K61.02508619
42UHMK11.01039560
43RET1.00918951
44CDK140.99276171
45PAK30.96556159
46CDK180.94428605
47CDK150.89737564
48DYRK1A0.89442865
49WNK30.89107267
50SGK4940.88234457
51SGK2230.88234457
52TNIK0.86647484
53RPS6KA40.85869637
54CAMK2A0.85394983
55CAMKK20.83419652
56NEK10.82453420
57CSNK1G30.82197356
58ARAF0.81767010
59OXSR10.78665650
60CDK11A0.77012044
61STK380.76803011
62RIPK40.73686338
63RPS6KA20.71230564
64MARK20.68893078
65SGK20.68607731
66OBSCN0.67954889
67CDK190.67834594
68CAMK2B0.66893638
69PRKCZ0.66306471
70STK110.66196176
71CAMK40.65545388
72PDK30.64851218
73PDK40.64851218
74SIK30.64207019
75ADRBK20.63781668
76NME10.63453838
77MAP2K10.62438195
78TAOK10.61588560
79TESK10.60366138
80BCR0.60282306
81GRK70.59502721
82DYRK30.58330720
83CSNK1A1L0.57409741
84SCYL20.55329142
85FER0.54910937
86BCKDK0.52706396
87DYRK1B0.51502826
88ALK0.51099408
89PRKCE0.50686182
90PINK10.50600019
91PRKACA0.50023412
92CSNK1G10.49548476
93PRKACB0.47638609
94SGK30.47160711
95GRK10.45969786
96PTK2B0.45914415
97PRPF4B0.45795136
98SGK10.44598131
99CSNK1D0.44307991
100CDK30.44099458
101CCNB10.43645276
102CAMK2G0.43419450
103INSRR0.41415648
104FES0.41015239
105CAMK2D0.40458525
106MAP3K50.40359091
107PRKG10.40118863
108CAMK10.40029441
109SRPK10.39810014
110PRKAA10.39204060
111MAPK120.39053895
112RPS6KA30.38633712
113BMPR1B0.37751746
114MAPK100.37607980
115ROCK10.36839426
116RAF10.36234722
117CSNK1E0.36174037
118CSNK1A10.35749433
119WNK10.35394682
120MUSK0.35321265
121CDC42BPA0.33738676
122PKN10.33450772
123TSSK60.33283747
124ROCK20.32710309
125ADRBK10.32450331
126MAPKAPK50.32179471
127EPHB20.31711027
128AKT30.30958976
129MAP2K60.30927900
130STK390.30859787
131FYN0.30829778
132MAPK90.30805365
133MAPK40.30485292
134STK38L0.30302737
135WNK40.28919922

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.40717310
2Nicotine addiction_Homo sapiens_hsa050333.37989967
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.00471215
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.57624161
5Olfactory transduction_Homo sapiens_hsa047402.56949588
6Circadian entrainment_Homo sapiens_hsa047132.46308502
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.41884721
8GABAergic synapse_Homo sapiens_hsa047272.39476992
9Long-term potentiation_Homo sapiens_hsa047202.34485342
10Dopaminergic synapse_Homo sapiens_hsa047282.28154756
11Glutamatergic synapse_Homo sapiens_hsa047242.23772324
12Amphetamine addiction_Homo sapiens_hsa050312.12100685
13Morphine addiction_Homo sapiens_hsa050322.11957808
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01032285
15Cholinergic synapse_Homo sapiens_hsa047251.95742207
16Salivary secretion_Homo sapiens_hsa049701.83553521
17Insulin secretion_Homo sapiens_hsa049111.83091790
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76758221
19Taste transduction_Homo sapiens_hsa047421.72086364
20Gastric acid secretion_Homo sapiens_hsa049711.71482549
21Serotonergic synapse_Homo sapiens_hsa047261.70143674
22Renin secretion_Homo sapiens_hsa049241.65728552
23Axon guidance_Homo sapiens_hsa043601.63863263
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60778494
25Oxytocin signaling pathway_Homo sapiens_hsa049211.60345647
26Gap junction_Homo sapiens_hsa045401.59737100
27Long-term depression_Homo sapiens_hsa047301.59260006
28Cocaine addiction_Homo sapiens_hsa050301.58459673
29GnRH signaling pathway_Homo sapiens_hsa049121.45026121
30Collecting duct acid secretion_Homo sapiens_hsa049661.43613378
31Butanoate metabolism_Homo sapiens_hsa006501.40720468
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38113286
33Calcium signaling pathway_Homo sapiens_hsa040201.37710068
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32789376
35Cardiac muscle contraction_Homo sapiens_hsa042601.29887160
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.28071114
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25184592
38Estrogen signaling pathway_Homo sapiens_hsa049151.24787641
39Oocyte meiosis_Homo sapiens_hsa041141.23847029
40ErbB signaling pathway_Homo sapiens_hsa040121.12310267
41Glioma_Homo sapiens_hsa052141.11655952
42cAMP signaling pathway_Homo sapiens_hsa040241.07821123
43Type II diabetes mellitus_Homo sapiens_hsa049301.05045071
44Melanogenesis_Homo sapiens_hsa049161.03859941
45Dorso-ventral axis formation_Homo sapiens_hsa043201.02783589
46Protein export_Homo sapiens_hsa030600.98250137
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96975738
48Vibrio cholerae infection_Homo sapiens_hsa051100.96575115
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96202634
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94781450
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94414662
52Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92026261
53Steroid biosynthesis_Homo sapiens_hsa001000.89383890
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88856888
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87471248
56Endometrial cancer_Homo sapiens_hsa052130.85742482
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85529944
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84652699
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.84122938
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.83279990
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.82130673
62Dilated cardiomyopathy_Homo sapiens_hsa054140.79348865
63Phototransduction_Homo sapiens_hsa047440.78348275
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.77861160
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.75569342
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74077873
67Insulin signaling pathway_Homo sapiens_hsa049100.73390969
68mTOR signaling pathway_Homo sapiens_hsa041500.72595666
69VEGF signaling pathway_Homo sapiens_hsa043700.71950593
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71551031
71Choline metabolism in cancer_Homo sapiens_hsa052310.70535390
72Colorectal cancer_Homo sapiens_hsa052100.69315380
73MAPK signaling pathway_Homo sapiens_hsa040100.68376196
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68077667
75Renal cell carcinoma_Homo sapiens_hsa052110.66765895
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66378309
77Ether lipid metabolism_Homo sapiens_hsa005650.65967118
78Glucagon signaling pathway_Homo sapiens_hsa049220.65843991
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63091673
80Alzheimers disease_Homo sapiens_hsa050100.62274672
81Thyroid hormone synthesis_Homo sapiens_hsa049180.62109765
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61651136
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.61409203
84Alcoholism_Homo sapiens_hsa050340.60612923
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60036807
86Pancreatic secretion_Homo sapiens_hsa049720.59423866
87Circadian rhythm_Homo sapiens_hsa047100.59144819
88beta-Alanine metabolism_Homo sapiens_hsa004100.57130654
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56553299
90Endocytosis_Homo sapiens_hsa041440.56261431
91Ras signaling pathway_Homo sapiens_hsa040140.55754767
92Wnt signaling pathway_Homo sapiens_hsa043100.55235101
93Parkinsons disease_Homo sapiens_hsa050120.54711480
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54036327
95Rap1 signaling pathway_Homo sapiens_hsa040150.53132022
96Hedgehog signaling pathway_Homo sapiens_hsa043400.51753829
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51129626
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50640546
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49421546
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46951434
101Prion diseases_Homo sapiens_hsa050200.46621130
102Basal transcription factors_Homo sapiens_hsa030220.45938816
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.45664771
104Peroxisome_Homo sapiens_hsa041460.44141842
105Oxidative phosphorylation_Homo sapiens_hsa001900.44129223
106Tight junction_Homo sapiens_hsa045300.42651792
107Huntingtons disease_Homo sapiens_hsa050160.40743935
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40715743
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.39825989
110Linoleic acid metabolism_Homo sapiens_hsa005910.39750886
111Non-small cell lung cancer_Homo sapiens_hsa052230.38695690
112Ovarian steroidogenesis_Homo sapiens_hsa049130.37818318
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37770288
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37494190
115Hippo signaling pathway_Homo sapiens_hsa043900.36653499
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35921012
117Regulation of autophagy_Homo sapiens_hsa041400.34782582
118Propanoate metabolism_Homo sapiens_hsa006400.34421971
119AMPK signaling pathway_Homo sapiens_hsa041520.33990232
120Prolactin signaling pathway_Homo sapiens_hsa049170.33795169
121Inositol phosphate metabolism_Homo sapiens_hsa005620.33374608
122Fatty acid elongation_Homo sapiens_hsa000620.31014987
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30936718
124Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28166653
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28085214
126Tryptophan metabolism_Homo sapiens_hsa003800.25421531
127Arginine and proline metabolism_Homo sapiens_hsa003300.23778573
128Phagosome_Homo sapiens_hsa041450.22101627
129Phenylalanine metabolism_Homo sapiens_hsa003600.21481934

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