REEP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.64148763
2central nervous system myelination (GO:0022010)9.64148763
3fatty acid elongation (GO:0030497)7.82268248
4ensheathment of neurons (GO:0007272)5.90775111
5axon ensheathment (GO:0008366)5.90775111
6myelination (GO:0042552)5.86061253
7cholesterol biosynthetic process (GO:0006695)5.16760904
8long-chain fatty acid biosynthetic process (GO:0042759)4.79271279
9myelin maintenance (GO:0043217)4.62724680
10sterol biosynthetic process (GO:0016126)4.53240055
11long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.31874918
12negative regulation of neurotransmitter secretion (GO:0046929)4.28878565
13response to lipoprotein particle (GO:0055094)4.03654229
14response to methylmercury (GO:0051597)4.02733662
15fatty-acyl-CoA biosynthetic process (GO:0046949)3.97533962
16asymmetric protein localization (GO:0008105)3.96314398
17creatine metabolic process (GO:0006600)3.94804611
18amyloid precursor protein metabolic process (GO:0042982)3.94262087
19long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.94034052
20adhesion of symbiont to host cell (GO:0044650)3.86661515
21virion attachment to host cell (GO:0019062)3.86661515
22import into cell (GO:0098657)3.82803832
23oligodendrocyte differentiation (GO:0048709)3.77152606
24very long-chain fatty acid metabolic process (GO:0000038)3.74817606
25negative regulation of protein localization to cell surface (GO:2000009)3.72085159
26fatty-acyl-CoA metabolic process (GO:0035337)3.66704323
27isoprenoid biosynthetic process (GO:0008299)3.66682239
28glycerophospholipid catabolic process (GO:0046475)3.65353279
29apical protein localization (GO:0045176)3.63424678
30negative regulation of neurotransmitter transport (GO:0051589)3.61954284
31regulation of type B pancreatic cell apoptotic process (GO:2000674)3.61284268
32regulation of lipoprotein metabolic process (GO:0050746)3.60625801
33positive regulation of oligodendrocyte differentiation (GO:0048714)3.58950971
34photoreceptor cell differentiation (GO:0046530)3.55858398
35eye photoreceptor cell differentiation (GO:0001754)3.55858398
36signal peptide processing (GO:0006465)3.53324697
37positive regulation of protein autophosphorylation (GO:0031954)3.50300201
38regulation of integrin-mediated signaling pathway (GO:2001044)3.46855137
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.44459301
40lactate metabolic process (GO:0006089)3.41032585
41regulation of collateral sprouting (GO:0048670)3.39479128
42L-phenylalanine catabolic process (GO:0006559)3.38898299
43erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.38898299
44intestinal epithelial cell development (GO:0060576)3.36178420
45astrocyte development (GO:0014002)3.31730117
46amyloid precursor protein catabolic process (GO:0042987)3.23177734
47adhesion of symbiont to host (GO:0044406)3.14085690
48heme transport (GO:0015886)3.13816508
49zinc ion transport (GO:0006829)3.13677740
50keratinocyte development (GO:0003334)3.11294730
51acyl-CoA biosynthetic process (GO:0071616)3.10488385
52thioester biosynthetic process (GO:0035384)3.10488385
53regulation of glucokinase activity (GO:0033131)3.08948924
54regulation of hexokinase activity (GO:1903299)3.08948924
55peripheral nervous system axon ensheathment (GO:0032292)3.08908576
56myelination in peripheral nervous system (GO:0022011)3.08908576
57water-soluble vitamin biosynthetic process (GO:0042364)3.07432391
58auditory receptor cell differentiation (GO:0042491)3.04472875
59COPII vesicle coating (GO:0048208)3.04307179
60L-amino acid import (GO:0043092)3.03698520
61protein localization to endosome (GO:0036010)3.02493998
62negative regulation of axon extension involved in axon guidance (GO:0048843)3.01447791
63nucleotide transmembrane transport (GO:1901679)2.97815899
64regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97524184
65positive regulation of glycolytic process (GO:0045821)2.96678383
66establishment of mitochondrion localization (GO:0051654)2.96304406
67limb bud formation (GO:0060174)2.95514920
68cellular ketone body metabolic process (GO:0046950)2.92140626
69negative regulation of execution phase of apoptosis (GO:1900118)2.90389336
70positive regulation of glycoprotein biosynthetic process (GO:0010560)2.89736551
71membrane tubulation (GO:0097320)2.86928292
72positive regulation of cellular amine metabolic process (GO:0033240)2.86817985
73lipid particle organization (GO:0034389)2.84744006
74L-phenylalanine metabolic process (GO:0006558)2.84345230
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.84345230
76UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80795002
77ketone body metabolic process (GO:1902224)2.80542985
78inositol phosphate catabolic process (GO:0071545)2.80365604
79desmosome organization (GO:0002934)2.80172958
80cholesterol metabolic process (GO:0008203)2.79840655
81membrane raft organization (GO:0031579)2.79516608
82axon development (GO:0061564)2.79509610
83cell adhesion mediated by integrin (GO:0033627)2.79418904
84lateral sprouting from an epithelium (GO:0060601)2.79339014
85positive regulation of glial cell differentiation (GO:0045687)2.77112396
86leukocyte migration involved in inflammatory response (GO:0002523)2.76597545
87negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.76491803
88platelet dense granule organization (GO:0060155)2.76081461
89regulation of protein glycosylation (GO:0060049)2.74956251
90regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.74854360
91regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73131128
92vascular smooth muscle contraction (GO:0014829)2.73099094
93negative regulation of complement activation (GO:0045916)2.71246358
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.68485220
95magnesium ion transport (GO:0015693)2.68269644
96sequestering of extracellular ligand from receptor (GO:0035581)2.68220477
97response to redox state (GO:0051775)2.67641325
98inositol phosphate-mediated signaling (GO:0048016)2.66463444
99interleukin-6-mediated signaling pathway (GO:0070102)2.65679237
100retinol metabolic process (GO:0042572)2.63742237
101membrane protein ectodomain proteolysis (GO:0006509)2.61443306
102substantia nigra development (GO:0021762)2.60487771
103iron coordination entity transport (GO:1901678)2.59374712
104proteasome assembly (GO:0043248)2.58406443
105glycosylceramide metabolic process (GO:0006677)2.58362236
106cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.58063935
107positive regulation of glycoprotein metabolic process (GO:1903020)2.57640837
108positive regulation of gliogenesis (GO:0014015)2.57394349
109sterol metabolic process (GO:0016125)2.56939120
110insulin secretion (GO:0030073)2.56231415
111kidney morphogenesis (GO:0060993)2.54130274
112enteric nervous system development (GO:0048484)2.53727941
113cerebral cortex radially oriented cell migration (GO:0021799)2.52775822
114regulation of somitogenesis (GO:0014807)2.52457019
115phosphorylated carbohydrate dephosphorylation (GO:0046838)2.52175002
116inositol phosphate dephosphorylation (GO:0046855)2.52175002
117negative regulation of axon guidance (GO:1902668)2.51931035
118zinc ion transmembrane transport (GO:0071577)2.51312705
119negative regulation of neurological system process (GO:0031645)2.50537667
120negative regulation of hormone biosynthetic process (GO:0032353)2.49746951
121peptide hormone processing (GO:0016486)2.48871341
122polyol catabolic process (GO:0046174)2.47724946
123prenylation (GO:0097354)2.47657193
124protein prenylation (GO:0018342)2.47657193
125regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.47284507
126presynaptic membrane organization (GO:0097090)2.47207026
127regulation of Rac protein signal transduction (GO:0035020)2.46610452
128cellular response to cholesterol (GO:0071397)2.46573893
129response to phenylpropanoid (GO:0080184)2.46358262
130positive regulation of macroautophagy (GO:0016239)2.45283667
131Leydig cell differentiation (GO:0033327)2.45198695
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45080314
133protein palmitoylation (GO:0018345)2.44807231
134acyl-CoA metabolic process (GO:0006637)2.42466926
135thioester metabolic process (GO:0035383)2.42466926
136GPI anchor metabolic process (GO:0006505)2.42230443
137branched-chain amino acid catabolic process (GO:0009083)2.40786372
138regulation of metalloenzyme activity (GO:0048552)2.40140783
139alcohol biosynthetic process (GO:0046165)2.39327304
140positive regulation of actin filament depolymerization (GO:0030836)2.39187459
141regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.38561293
142xenobiotic catabolic process (GO:0042178)2.38417544
143regulation of keratinocyte proliferation (GO:0010837)2.37290530
144protein heterotetramerization (GO:0051290)2.37109542
145glomerular filtration (GO:0003094)2.36807962
146positive regulation of response to nutrient levels (GO:0032109)2.36730294
147positive regulation of response to extracellular stimulus (GO:0032106)2.36730294
148steroid biosynthetic process (GO:0006694)2.35860367
149negative regulation of protein activation cascade (GO:2000258)2.35664237
150regulation of transforming growth factor beta1 production (GO:0032908)2.35585103
151GPI anchor biosynthetic process (GO:0006506)2.35538500
152hair cell differentiation (GO:0035315)2.35356398
153regulation of protein autophosphorylation (GO:0031952)2.35281933
154keratan sulfate catabolic process (GO:0042340)2.35250753
155prostate gland growth (GO:0060736)2.34111989
156regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.34073803
157amino acid import (GO:0043090)2.34022310
158regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.32527554
159respiratory chain complex IV assembly (GO:0008535)2.32284964
160intraciliary transport (GO:0042073)2.31906263
161regulation of sulfur metabolic process (GO:0042762)2.31272360
162negative regulation of JUN kinase activity (GO:0043508)2.31254208
163smooth muscle tissue development (GO:0048745)2.31240089
164cellular response to vitamin D (GO:0071305)2.30683453
165glial cell differentiation (GO:0010001)2.30225992
166chondrocyte proliferation (GO:0035988)2.30054045
167presynaptic membrane assembly (GO:0097105)2.28553240
168glutathione biosynthetic process (GO:0006750)2.28546722
169fibroblast migration (GO:0010761)2.27925497
170organ growth (GO:0035265)2.27837724
171triglyceride biosynthetic process (GO:0019432)2.27585028
172nucleotide transport (GO:0006862)2.27214676
173regulation of execution phase of apoptosis (GO:1900117)2.24909182
174peripheral nervous system development (GO:0007422)2.24634483
175ER to Golgi vesicle-mediated transport (GO:0006888)2.23964698
176neutral lipid biosynthetic process (GO:0046460)2.23274464
177acylglycerol biosynthetic process (GO:0046463)2.23274464
178tonic smooth muscle contraction (GO:0014820)2.21506545
179parental behavior (GO:0060746)2.21277692
180peptidyl-cysteine modification (GO:0018198)2.20810548
181negative regulation of hormone metabolic process (GO:0032351)2.19965447
182detection of calcium ion (GO:0005513)2.19368389
183endocrine pancreas development (GO:0031018)2.17339555
184protein localization to cilium (GO:0061512)2.12816691
185artery development (GO:0060840)2.12521352
186positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.12144691
187response to gravity (GO:0009629)2.11935852
188positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.11629347
189mannosylation (GO:0097502)2.11169668
190response to pheromone (GO:0019236)2.10656877
191membrane budding (GO:0006900)2.10610807
192pteridine-containing compound biosynthetic process (GO:0042559)2.10239133
193coenzyme catabolic process (GO:0009109)2.10095551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.02022543
2TRIM28_21343339_ChIP-Seq_HEK293_Human2.51565055
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37609069
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.32287744
5* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.20344165
6GBX2_23144817_ChIP-Seq_PC3_Human2.05444703
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.00275669
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.98697258
9* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93714653
10FLI1_27457419_Chip-Seq_LIVER_Mouse1.93053885
11FUS_26573619_Chip-Seq_HEK293_Human1.92796408
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.90129038
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.84640822
14WT1_19549856_ChIP-ChIP_CCG9911_Human1.82268949
15* LXR_22158963_ChIP-Seq_LIVER_Mouse1.74813038
16* SMAD4_21799915_ChIP-Seq_A2780_Human1.74575609
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73935975
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73878630
19NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.72957582
20NRF2_20460467_ChIP-Seq_MEFs_Mouse1.72957582
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.68248694
22* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.67095735
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.66027359
24FOXM1_26456572_ChIP-Seq_MCF-7_Human1.65506614
25BRD4_25478319_ChIP-Seq_HGPS_Human1.65266263
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64588552
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61658097
28ZNF274_21170338_ChIP-Seq_K562_Hela1.61242715
29* EZH2_27294783_Chip-Seq_NPCs_Mouse1.60421582
30RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.58674691
31EWS_26573619_Chip-Seq_HEK293_Human1.58525323
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57374345
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.56370325
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55857482
35TAF15_26573619_Chip-Seq_HEK293_Human1.55779674
36SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54370556
37BCAT_22108803_ChIP-Seq_LS180_Human1.54050703
38TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52309682
39AR_21572438_ChIP-Seq_LNCaP_Human1.51658679
40* FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49337788
41EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.49103779
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.48458546
43* RXR_22158963_ChIP-Seq_LIVER_Mouse1.47805549
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.47713847
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46428294
46CDX2_22108803_ChIP-Seq_LS180_Human1.46313306
47ELK1_19687146_ChIP-ChIP_HELA_Human1.44105438
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.42527075
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42328649
50AR_25329375_ChIP-Seq_VCAP_Human1.41874016
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40500630
52VDR_22108803_ChIP-Seq_LS180_Human1.40093815
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40041586
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.39692265
55P53_22387025_ChIP-Seq_ESCs_Mouse1.39196873
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38987422
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38947263
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37656217
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.37511308
60* STAT3_23295773_ChIP-Seq_U87_Human1.36891259
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35842774
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35842774
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.34970734
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34954261
65ER_23166858_ChIP-Seq_MCF-7_Human1.34730174
66* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33225189
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32682151
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32415769
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32392960
70* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31778811
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.30355971
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29044315
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28471482
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.26957267
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26930190
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.26568889
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25964829
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.24011215
79* CRX_20693478_ChIP-Seq_RETINA_Mouse1.23768944
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.22603902
81TCF4_22108803_ChIP-Seq_LS180_Human1.22366545
82SOX2_18555785_Chip-Seq_ESCs_Mouse1.21911565
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21315808
84* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20624547
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20613471
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20567203
87SOX2_20726797_ChIP-Seq_SW620_Human1.19005771
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18984221
89TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18455586
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18258367
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.18229368
92CJUN_26792858_Chip-Seq_BT549_Human1.17163912
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16205393
94* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16032921
95TCF4_23295773_ChIP-Seq_U87_Human1.15076513
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14732927
97P300_18555785_Chip-Seq_ESCs_Mouse1.14679942
98SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14402474
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13455282
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13442261
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12400489
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11919013
103* FOXO3_23340844_ChIP-Seq_DLD1_Human1.11148603
104NANOG_19829295_ChIP-Seq_ESCs_Human1.11076511
105SOX2_19829295_ChIP-Seq_ESCs_Human1.11076511
106CBP_20019798_ChIP-Seq_JUKART_Human1.11034378
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11034378
108EZH2_27294783_Chip-Seq_ESCs_Mouse1.10683654
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09123933
110OCT4_18555785_Chip-Seq_ESCs_Mouse1.08710173
111* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08214530
112TP53_16413492_ChIP-PET_HCT116_Human1.07760709
113* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06829036
114RNF2_27304074_Chip-Seq_ESCs_Mouse1.05232329
115* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.04950084
116AHR_22903824_ChIP-Seq_MCF-7_Human1.04689669
117TBL1_22424771_ChIP-Seq_293T_Human1.04332765
118* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03910530
119TP53_18474530_ChIP-ChIP_U2OS_Human1.03767892
120* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03367493
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03145000
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.03068579
123SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02841389
124JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02482772
125* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02123053
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01839961
127* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01726603
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.00586684
129KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00497479
130KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00497479
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00497479
132* CBX2_27304074_Chip-Seq_ESCs_Mouse0.99871127
133KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99481654
134* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99055215
135GATA4_25053715_ChIP-Seq_YYC3_Human0.99039252
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.99027715
137FOXA2_19822575_ChIP-Seq_HepG2_Human0.97396439
138* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95740246
139PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95563698
140* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95093755
141* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94927603
142* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.94914444
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94736583
144* TP63_23658742_ChIP-Seq_EP156T_Human0.94643128
145RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93619284
146VDR_24787735_ChIP-Seq_THP-1_Human0.93314572
147BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92638699
148* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91447025
149* P300_19829295_ChIP-Seq_ESCs_Human0.90421884
150* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90259058
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89812370
152P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89505227
153CMYC_18555785_Chip-Seq_ESCs_Mouse0.88995354
154* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.88863648
155HTT_18923047_ChIP-ChIP_STHdh_Human0.88842598
156LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86747661
157FOXA1_25552417_ChIP-Seq_VCAP_Human0.86317034
158TAL1_26923725_Chip-Seq_HPCs_Mouse0.85523147
159LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85117370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.37428693
2MP0009780_abnormal_chondrocyte_physiolo4.75554518
3MP0010234_abnormal_vibrissa_follicle4.16569513
4MP0003950_abnormal_plasma_membrane4.00423670
5MP0003690_abnormal_glial_cell3.59456153
6MP0006054_spinal_hemorrhage3.54468379
7MP0002837_dystrophic_cardiac_calcinosis3.24814638
8MP0005171_absent_coat_pigmentation3.17991121
9MP0003136_yellow_coat_color2.76467457
10MP0005451_abnormal_body_composition2.61243515
11MP0010678_abnormal_skin_adnexa2.60723415
12MP0008438_abnormal_cutaneous_collagen2.55705037
13MP0000383_abnormal_hair_follicle2.43239904
14MP0004381_abnormal_hair_follicle2.30865466
15MP0005379_endocrine/exocrine_gland_phen2.19659517
16MP0003195_calcinosis2.17470633
17MP0000013_abnormal_adipose_tissue2.13446190
18MP0004885_abnormal_endolymph2.10467826
19MP0004742_abnormal_vestibular_system2.06269809
20MP0003634_abnormal_glial_cell2.02159872
21MP0003806_abnormal_nucleotide_metabolis1.98616258
22MP0002876_abnormal_thyroid_physiology1.98446556
23MP0002909_abnormal_adrenal_gland1.98259039
24MP0010386_abnormal_urinary_bladder1.97201792
25MP0000569_abnormal_digit_pigmentation1.96223614
26MP0003329_amyloid_beta_deposits1.95877457
27MP0005409_darkened_coat_color1.91673271
28MP0002254_reproductive_system_inflammat1.90697274
29MP0000427_abnormal_hair_cycle1.89361073
30MP0005058_abnormal_lysosome_morphology1.87406995
31MP0005360_urolithiasis1.84597851
32MP0010352_gastrointestinal_tract_polyps1.83944689
33MP0002938_white_spotting1.81563814
34MP0008775_abnormal_heart_ventricle1.81549584
35MP0006072_abnormal_retinal_apoptosis1.80904328
36MP0005367_renal/urinary_system_phenotyp1.76994929
37MP0000516_abnormal_urinary_system1.76994929
38MP0003283_abnormal_digestive_organ1.74087442
39MP0005084_abnormal_gallbladder_morpholo1.73977872
40MP0000462_abnormal_digestive_system1.73845314
41MP0002102_abnormal_ear_morphology1.73111033
42MP0002139_abnormal_hepatobiliary_system1.73091987
43MP0009840_abnormal_foam_cell1.72089624
44MP0000647_abnormal_sebaceous_gland1.61657627
45MP0001485_abnormal_pinna_reflex1.60737558
46MP0004272_abnormal_basement_membrane1.58111878
47MP0004134_abnormal_chest_morphology1.56009348
48MP0000538_abnormal_urinary_bladder1.54770435
49MP0003632_abnormal_nervous_system1.53077099
50MP0001756_abnormal_urination1.52873429
51MP0000604_amyloidosis1.50230316
52MP0004084_abnormal_cardiac_muscle1.49248053
53MP0005085_abnormal_gallbladder_physiolo1.48910496
54MP0008875_abnormal_xenobiotic_pharmacok1.48889932
55MP0002295_abnormal_pulmonary_circulatio1.48545882
56MP0001851_eye_inflammation1.47713340
57MP0000566_synostosis1.46922152
58MP0001944_abnormal_pancreas_morphology1.46848568
59MP0006082_CNS_inflammation1.46772809
60MP0004215_abnormal_myocardial_fiber1.46561036
61MP0001346_abnormal_lacrimal_gland1.45260683
62MP0000372_irregular_coat_pigmentation1.43963495
63MP0005248_abnormal_Harderian_gland1.43528447
64MP0010368_abnormal_lymphatic_system1.43064120
65MP0000579_abnormal_nail_morphology1.40612554
66MP0001661_extended_life_span1.38217509
67MP0000762_abnormal_tongue_morphology1.38016115
68MP0005408_hypopigmentation1.36821919
69MP0004185_abnormal_adipocyte_glucose1.36057852
70MP0002796_impaired_skin_barrier1.35624902
71MP0003453_abnormal_keratinocyte_physiol1.34410242
72MP0002163_abnormal_gland_morphology1.33029253
73MP0000778_abnormal_nervous_system1.27642365
74MP0003941_abnormal_skin_development1.25079501
75MP0004270_analgesia1.25059356
76MP0005623_abnormal_meninges_morphology1.22428836
77MP0001905_abnormal_dopamine_level1.21330211
78MP0010329_abnormal_lipoprotein_level1.20546326
79MP0002234_abnormal_pharynx_morphology1.18855144
80MP0005187_abnormal_penis_morphology1.17838417
81MP0009384_cardiac_valve_regurgitation1.15216401
82MP0002009_preneoplasia1.15116979
83MP0000467_abnormal_esophagus_morphology1.15057697
84MP0004142_abnormal_muscle_tone1.13924738
85MP0002693_abnormal_pancreas_physiology1.13260032
86MP0004019_abnormal_vitamin_homeostasis1.13126879
87MP0002118_abnormal_lipid_homeostasis1.12028962
88MP0005253_abnormal_eye_physiology1.11026660
89MP0002229_neurodegeneration1.09204036
90MP0001299_abnormal_eye_distance/1.08853977
91MP0003566_abnormal_cell_adhesion1.08302421
92MP0001879_abnormal_lymphatic_vessel1.07731693
93MP0002168_other_aberrant_phenotype1.07632987
94MP0009250_abnormal_appendicular_skeleto1.06499880
95MP0002098_abnormal_vibrissa_morphology1.03917969
96MP0001486_abnormal_startle_reflex1.03630505
97MP0002166_altered_tumor_susceptibility1.03268258
98MP0003868_abnormal_feces_composition1.00947836
99MP0003631_nervous_system_phenotype0.99212404
100MP0003937_abnormal_limbs/digits/tail_de0.97994382
101MP0003279_aneurysm0.97970092
102MP0005275_abnormal_skin_tensile0.97824712
103MP0001340_abnormal_eyelid_morphology0.97232124
104MP0003724_increased_susceptibility_to0.96880648
105MP0009697_abnormal_copulation0.96175309
106MP0001666_abnormal_nutrient_absorption0.94415618
107MP0002933_joint_inflammation0.94410969
108MP0001984_abnormal_olfaction0.94400147
109MP0005365_abnormal_bile_salt0.94223794
110MP0005220_abnormal_exocrine_pancreas0.93771734
111MP0005174_abnormal_tail_pigmentation0.93014689
112MP0005410_abnormal_fertilization0.91264846
113MP0004484_altered_response_of0.89128412
114MP0004085_abnormal_heartbeat0.88934769
115MP0005332_abnormal_amino_acid0.88695891
116MP0001958_emphysema0.88677981
117MP0005646_abnormal_pituitary_gland0.87796416
118MP0004147_increased_porphyrin_level0.87722444
119MP0003252_abnormal_bile_duct0.86939787
120MP0005083_abnormal_biliary_tract0.86795044
121MP0001177_atelectasis0.85811888
122MP0002060_abnormal_skin_morphology0.85368271
123MP0002133_abnormal_respiratory_system0.85212737
124MP0005388_respiratory_system_phenotype0.85212737
125MP0003938_abnormal_ear_development0.84471543
126MP0000230_abnormal_systemic_arterial0.84075898
127MP0005164_abnormal_response_to0.83869983
128MP0003633_abnormal_nervous_system0.83330671
129MP0003186_abnormal_redox_activity0.82401708
130MP0000639_abnormal_adrenal_gland0.82242615
131MP0001529_abnormal_vocalization0.81040316
132MP0005195_abnormal_posterior_eye0.80540978
133MP0004043_abnormal_pH_regulation0.80479110
134MP0005395_other_phenotype0.79719058
135MP0005257_abnormal_intraocular_pressure0.79514340
136MP0008057_abnormal_DNA_replication0.78567079
137MP0000377_abnormal_hair_follicle0.78513133
138MP0005165_increased_susceptibility_to0.76672319
139MP0002272_abnormal_nervous_system0.76238482
140MP0002282_abnormal_trachea_morphology0.75174937
141MP0004036_abnormal_muscle_relaxation0.74541540
142MP0000749_muscle_degeneration0.74415857
143MP0000767_abnormal_smooth_muscle0.73664160
144MP0003191_abnormal_cellular_cholesterol0.73398335
145MP0002006_tumorigenesis0.73392317
146MP0005645_abnormal_hypothalamus_physiol0.71932232
147MP0002896_abnormal_bone_mineralization0.70939587
148MP0002078_abnormal_glucose_homeostasis0.70086376
149MP0003880_abnormal_central_pattern0.68470172
150MP0005503_abnormal_tendon_morphology0.68179140
151MP0005595_abnormal_vascular_smooth0.68042803
152MP0005023_abnormal_wound_healing0.67741112
153MP0005636_abnormal_mineral_homeostasis0.66777200
154MP0001963_abnormal_hearing_physiology0.66145108
155MP0010771_integument_phenotype0.65652412
156MP0005375_adipose_tissue_phenotype0.63191572
157MP0003011_delayed_dark_adaptation0.63155282
158MP0008260_abnormal_autophagy0.62779836
159MP0005551_abnormal_eye_electrophysiolog0.62529078
160MP0003075_altered_response_to0.62298318
161MP0005508_abnormal_skeleton_morphology0.62251825
162MP0005584_abnormal_enzyme/coenzyme_acti0.61744556
163MP0002108_abnormal_muscle_morphology0.61560989
164MP0000747_muscle_weakness0.61427859
165MP0000465_gastrointestinal_hemorrhage0.61011433
166MP0000613_abnormal_salivary_gland0.60831082
167MP0002090_abnormal_vision0.60770767
168MP0000003_abnormal_adipose_tissue0.59189552

Predicted human phenotypes

RankGene SetZ-score
1Neurofibrillary tangles (HP:0002185)5.93913183
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.90686594
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.90686594
4Parakeratosis (HP:0001036)5.59592163
5Sensory axonal neuropathy (HP:0003390)4.39246657
6Cerebral inclusion bodies (HP:0100314)4.04881467
7Abnormality of the corticospinal tract (HP:0002492)4.04735517
8Hypoglycemic coma (HP:0001325)3.61994148
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.60809508
10Onion bulb formation (HP:0003383)3.44090911
11Peripheral hypomyelination (HP:0007182)3.42283569
12Hypothermia (HP:0002045)3.42195128
13Intrahepatic cholestasis (HP:0001406)3.33040779
14Tongue fasciculations (HP:0001308)3.32207961
15Coronal craniosynostosis (HP:0004440)3.31171106
16Hyperglycemia (HP:0003074)3.24129739
17Hypoglycemic seizures (HP:0002173)3.15644796
18Hyperinsulinemic hypoglycemia (HP:0000825)3.14371471
19Congenital ichthyosiform erythroderma (HP:0007431)3.11250500
20Premature skin wrinkling (HP:0100678)3.07332031
21Alacrima (HP:0000522)3.04819538
22Metaphyseal dysplasia (HP:0100255)3.02531554
23Intention tremor (HP:0002080)2.90432923
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87960994
25Hamartoma of the eye (HP:0010568)2.83095791
26Enlarged penis (HP:0000040)2.78701745
27Disproportionate short-trunk short stature (HP:0003521)2.77660841
28Axonal loss (HP:0003447)2.76949115
29Hypophosphatemic rickets (HP:0004912)2.73366939
30Insidious onset (HP:0003587)2.71739082
31Termporal pattern (HP:0011008)2.71739082
32Abnormal auditory evoked potentials (HP:0006958)2.70971718
33Conjunctival hamartoma (HP:0100780)2.70885564
34Ketoacidosis (HP:0001993)2.69400501
35Clumsiness (HP:0002312)2.68660648
36Muscle fibrillation (HP:0010546)2.66326916
37Anteriorly placed anus (HP:0001545)2.65330700
38Medial flaring of the eyebrow (HP:0010747)2.65281336
39Renal cortical cysts (HP:0000803)2.62904334
40Hepatosplenomegaly (HP:0001433)2.62036713
41Stridor (HP:0010307)2.60997464
42Hyperlipoproteinemia (HP:0010980)2.60207912
43Mitral stenosis (HP:0001718)2.60062433
44Hemiparesis (HP:0001269)2.59655983
45Abnormality of vitamin B metabolism (HP:0004340)2.59414158
46Large for gestational age (HP:0001520)2.58739220
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.58249793
48Double outlet right ventricle (HP:0001719)2.56530899
49Congenital malformation of the right heart (HP:0011723)2.56530899
50Segmental peripheral demyelination/remyelination (HP:0003481)2.54123079
51Xanthomatosis (HP:0000991)2.53573579
52Thickened helices (HP:0000391)2.51436126
53Hypoplasia of the iris (HP:0007676)2.50337213
54Cerebral hemorrhage (HP:0001342)2.50261126
55Supranuclear gaze palsy (HP:0000605)2.49614412
56Spastic paraparesis (HP:0002313)2.49507703
57Congenital sensorineural hearing impairment (HP:0008527)2.47955493
58Abnormality of the phalanges of the 2nd finger (HP:0009541)2.47651897
59Insulin-resistant diabetes mellitus (HP:0000831)2.47470264
60Intestinal atresia (HP:0011100)2.45753732
61Popliteal pterygium (HP:0009756)2.43640022
62Slow saccadic eye movements (HP:0000514)2.41844247
63Progressive macrocephaly (HP:0004481)2.41007861
64Hypoplastic pelvis (HP:0008839)2.40388797
65Proximal tubulopathy (HP:0000114)2.40226832
66White forelock (HP:0002211)2.37587229
67Premature rupture of membranes (HP:0001788)2.34628754
68Abnormality of the renal cortex (HP:0011035)2.34334704
69Spastic gait (HP:0002064)2.34117786
70Infantile muscular hypotonia (HP:0008947)2.33996831
71Autoamputation (HP:0001218)2.32811108
72Patchy hypopigmentation of hair (HP:0011365)2.29702141
73Deep venous thrombosis (HP:0002625)2.29160121
74Pancreatic islet-cell hyperplasia (HP:0004510)2.28779597
75Hematochezia (HP:0002573)2.26717593
76Decreased lacrimation (HP:0000633)2.26367742
77Humeroradial synostosis (HP:0003041)2.25283893
78Synostosis involving the elbow (HP:0003938)2.25283893
79Abnormality of vitamin metabolism (HP:0100508)2.24215288
80Peripheral demyelination (HP:0011096)2.22515875
81Abnormality of the middle phalanges of the toes (HP:0010183)2.21372611
82Congenital, generalized hypertrichosis (HP:0004540)2.19647195
83Aqueductal stenosis (HP:0002410)2.18631548
84Symptomatic seizures (HP:0011145)2.18356515
85Delayed gross motor development (HP:0002194)2.16636564
86Aplasia involving bones of the upper limbs (HP:0009823)2.16572962
87Aplasia of the phalanges of the hand (HP:0009802)2.16572962
88Aplasia involving bones of the extremities (HP:0009825)2.16572962
89Erythroderma (HP:0001019)2.13307838
90Akinesia (HP:0002304)2.12475945
91Pancreatic fibrosis (HP:0100732)2.12211580
92Furrowed tongue (HP:0000221)2.12067712
93Metabolic alkalosis (HP:0200114)2.11776394
94Increased CSF protein (HP:0002922)2.10397763
95Dysmetria (HP:0001310)2.09498672
96Buphthalmos (HP:0000557)2.06308399
97Amyloidosis (HP:0011034)2.06206231
98Turricephaly (HP:0000262)2.04089201
99Adrenal hypoplasia (HP:0000835)2.03231296
100Methylmalonic acidemia (HP:0002912)2.03130935
101Hypokalemic alkalosis (HP:0001949)2.02907435
102Hypokinesia (HP:0002375)2.02720517
103Bone cyst (HP:0012062)2.01471360
104Neuroendocrine neoplasm (HP:0100634)2.01468906
105Pheochromocytoma (HP:0002666)2.00579503
106Prolonged partial thromboplastin time (HP:0003645)1.99944803
107Abnormality of urine glucose concentration (HP:0011016)1.99689038
108Glycosuria (HP:0003076)1.99689038
109True hermaphroditism (HP:0010459)1.98505447
110Paraparesis (HP:0002385)1.97805884
111Absent septum pellucidum (HP:0001331)1.97675101
112Prolonged neonatal jaundice (HP:0006579)1.96792062
113Abnormal biliary tract morphology (HP:0012440)1.96498346
114Breast carcinoma (HP:0003002)1.96139230
115Hyporeflexia of lower limbs (HP:0002600)1.96087615
116Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95680507
117Hypoplasia of the fovea (HP:0007750)1.95534467
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.95534467
119Scanning speech (HP:0002168)1.94884423
120Cupped ear (HP:0000378)1.94057562
121Thyroid carcinoma (HP:0002890)1.93458625
122Neoplasm of the adrenal cortex (HP:0100641)1.93406721
123Nephronophthisis (HP:0000090)1.93360283
124Bifid scrotum (HP:0000048)1.91720465
125Esophageal atresia (HP:0002032)1.91321425
126Abnormality of methionine metabolism (HP:0010901)1.90717533
127Follicular hyperkeratosis (HP:0007502)1.90389788
128Pancreatic cysts (HP:0001737)1.89393205
129Congenital primary aphakia (HP:0007707)1.89113445
130Neoplasm of the adrenal gland (HP:0100631)1.87872207
131Increased serum pyruvate (HP:0003542)1.87839639
132Abnormality of glycolysis (HP:0004366)1.87839639
133Vascular calcification (HP:0004934)1.86818218
134Fat malabsorption (HP:0002630)1.84241277
135Ileus (HP:0002595)1.84144276
136Acute necrotizing encephalopathy (HP:0006965)1.83682735
137Steatorrhea (HP:0002570)1.82884743
138Hydroxyprolinuria (HP:0003080)1.82605312
139Abnormality of proline metabolism (HP:0010907)1.82605312
140Anomalous pulmonary venous return (HP:0010772)1.82036156
141Epidermoid cyst (HP:0200040)1.81924351
142Leukodystrophy (HP:0002415)1.81395086
143Right ventricular cardiomyopathy (HP:0011663)1.80972472
144Hypobetalipoproteinemia (HP:0003563)1.80566403
145Congenital glaucoma (HP:0001087)1.80496270
146Partial duplication of thumb phalanx (HP:0009944)1.79683388
147Myelomeningocele (HP:0002475)1.79183177
148Retinal dysplasia (HP:0007973)1.78144418
149Albinism (HP:0001022)1.77608893
150Abnormality of the renal medulla (HP:0100957)1.77529567
151Cardiovascular calcification (HP:0011915)1.77402112
152Palpitations (HP:0001962)1.76975885
153Increased circulating renin level (HP:0000848)1.76942838
154Split foot (HP:0001839)1.76286324
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.75433256
156Osteolytic defects of the hand bones (HP:0009699)1.75433256
157Rickets (HP:0002748)1.74873627
158Tubular atrophy (HP:0000092)1.74197267
159Thick nail (HP:0001805)1.74131161
160Molar tooth sign on MRI (HP:0002419)1.74077143
161Abnormality of midbrain morphology (HP:0002418)1.74077143
162Abnormality of the 2nd finger (HP:0004100)1.73171986
163Partial agenesis of the corpus callosum (HP:0001338)1.72886420
164Barrel-shaped chest (HP:0001552)1.72746358
165Loss of speech (HP:0002371)1.72075371
166Cerebral hypomyelination (HP:0006808)1.71832221
167Abnormal albumin level (HP:0012116)1.71628659
168Hypoalbuminemia (HP:0003073)1.71628659
169Gait imbalance (HP:0002141)1.70786021
170Acute encephalopathy (HP:0006846)1.69534401
171Irregular vertebral endplates (HP:0003301)1.69128156
172Hypomagnesemia (HP:0002917)1.68904498
173Muscle fiber splitting (HP:0003555)1.68342441
174Stillbirth (HP:0003826)1.67316990
175Spastic tetraparesis (HP:0001285)1.67282296
176Abnormality of the pulmonary veins (HP:0011718)1.66474151
177Median cleft lip (HP:0000161)1.66423438
178Abnormality of the pancreatic islet cells (HP:0006476)1.66420002
179Abnormality of endocrine pancreas physiology (HP:0012093)1.66420002
180Genital tract atresia (HP:0001827)1.66027362
181Papillary thyroid carcinoma (HP:0002895)1.64783046
182Vascular tortuosity (HP:0004948)1.63685499
183Methylmalonic aciduria (HP:0012120)1.62632625
184Meningioma (HP:0002858)1.60723532
185Aplasia/Hypoplasia of the tongue (HP:0010295)1.60544477
186Arthropathy (HP:0003040)1.60223781
187Arterial tortuosity (HP:0005116)1.60020674
188Cutaneous melanoma (HP:0012056)1.58961160
189Abnormality of the fovea (HP:0000493)1.58187977

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.11099736
2FRK5.61509678
3EPHB14.25481611
4OXSR14.09801956
5PBK2.86626220
6MET2.73034911
7BCR2.64960093
8MAP3K122.49153599
9WNK42.45512852
10PKN12.43807514
11FER2.43406832
12ERBB32.25470139
13FGFR22.23785131
14MAPKAPK52.23230974
15TRIM282.21518734
16ACVR1B2.06418656
17MAPK152.05082441
18MST42.04712579
19EIF2AK32.02707933
20MYLK2.01096581
21ICK1.95284841
22WNK31.87770585
23WNK11.87196853
24STK38L1.83823610
25EIF2AK11.81523549
26FGR1.73057550
27STK31.69198666
28PLK21.68874002
29LIMK11.68826379
30MAP4K21.66217631
31CSNK1A1L1.63530914
32BRSK21.53348433
33TNIK1.51752595
34STK241.50023343
35CDK191.48569578
36CSNK1G31.42488629
37MKNK21.38725387
38CSNK1G11.36783076
39NEK61.35673327
40TRPM71.32285612
41DDR21.30312480
42UHMK11.30165428
43ROCK21.24900969
44CLK11.23384322
45PINK11.16234444
46PLK31.13511386
47CAMK2B1.12396463
48EPHA21.11554827
49ERBB41.08430330
50NTRK11.05145027
51CAMK2D1.00432344
52TAF10.99154745
53CSNK1G20.98487870
54TYRO30.93969943
55PTK2B0.93659217
56BMX0.92896826
57ADRBK20.92346662
58IRAK20.91092855
59TGFBR20.90945722
60PRKCQ0.90823251
61BMPR1B0.89002004
62GSK3A0.88971389
63PRPF4B0.88599830
64AKT30.88370196
65PAK30.88097225
66CSK0.87684063
67IRAK10.87303779
68TESK20.87172203
69MST1R0.86604869
70FGFR30.86595205
71SGK4940.85538530
72SGK2230.85538530
73PRKD10.84624517
74PAK40.84442263
75MAP3K20.82725313
76CAMK1G0.81657484
77ROCK10.80512730
78CAMK2G0.79277309
79ILK0.76350187
80TGFBR10.71886396
81TIE10.71441360
82DYRK20.71160850
83BLK0.70424505
84EPHA30.69592488
85FLT30.69128311
86CASK0.68525652
87SIK30.67867273
88LMTK20.67069049
89PRKCE0.66689554
90MAP2K20.65493913
91NLK0.64700071
92PDGFRB0.64171989
93FGFR10.64155996
94MARK20.62437503
95TESK10.61173635
96INSRR0.60305055
97WEE10.59987476
98BMPR20.58151940
99MAP3K140.57786778
100PIK3CA0.57466550
101ADRBK10.57340556
102ITK0.56785806
103MAP3K40.56347110
104PDPK10.55140701
105NEK10.54331070
106DMPK0.53948233
107CAMK2A0.53711236
108PNCK0.52846955
109PRKD30.52554733
110GRK10.52457424
111RPS6KA50.51859899
112INSR0.50826867
113NUAK10.50220632
114FYN0.49953356
115PRKCI0.49820865
116EPHB20.48614777
117CAMK1D0.48566879
118HIPK20.47162514
119CDK80.46207900
120MAP2K10.45709165
121ABL10.45398187
122NEK90.45028289
123PAK60.44304289
124LATS10.43697260
125DYRK1B0.43316647
126PRKG10.42064851
127MAPKAPK30.41928836
128STK100.41844566
129PRKD20.41507303
130PAK20.40909533
131CSNK1D0.40524373
132PRKAA20.39608112
133MAPK70.39056477
134YES10.38644436
135TSSK60.38170002
136SIK10.37751253
137IRAK40.36913587
138CAMKK20.36839784
139BRSK10.36653836
140PRKCG0.34795870
141PIK3CG0.34710544
142MKNK10.34379811
143CDK140.34295768
144PTK20.34124308
145PRKCH0.33869442
146LCK0.31955012
147MUSK0.31555409
148PRKACB0.30387921
149CSNK1A10.30126530
150PHKG10.29357451
151PHKG20.29357451
152MAP3K30.29316933
153EGFR0.29281355
154STK40.28074346
155EIF2AK20.27835470
156IGF1R0.26719884

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001005.05872266
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.54349430
3Fatty acid elongation_Homo sapiens_hsa000624.40486656
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.30954853
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.04586516
6Ether lipid metabolism_Homo sapiens_hsa005652.54838988
7Histidine metabolism_Homo sapiens_hsa003402.35936076
8Sulfur metabolism_Homo sapiens_hsa009202.27884732
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.18089008
10Nitrogen metabolism_Homo sapiens_hsa009101.98925490
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79366621
12Sphingolipid metabolism_Homo sapiens_hsa006001.77900840
13Butanoate metabolism_Homo sapiens_hsa006501.77857593
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72389147
15Proteasome_Homo sapiens_hsa030501.64438508
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58391420
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.58230154
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57740584
19Fatty acid metabolism_Homo sapiens_hsa012121.57473489
20Linoleic acid metabolism_Homo sapiens_hsa005911.51622081
21Circadian rhythm_Homo sapiens_hsa047101.48218827
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45607718
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.43129406
24Selenocompound metabolism_Homo sapiens_hsa004501.38896467
25Arginine and proline metabolism_Homo sapiens_hsa003301.35233837
26Complement and coagulation cascades_Homo sapiens_hsa046101.23689041
27Staphylococcus aureus infection_Homo sapiens_hsa051501.22975980
28Protein export_Homo sapiens_hsa030601.21804275
29Collecting duct acid secretion_Homo sapiens_hsa049661.20024457
30Peroxisome_Homo sapiens_hsa041461.18882783
31Insulin secretion_Homo sapiens_hsa049111.18294451
32Fatty acid biosynthesis_Homo sapiens_hsa000611.15416581
33Axon guidance_Homo sapiens_hsa043601.15133170
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.15090693
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11014811
36Propanoate metabolism_Homo sapiens_hsa006401.09134231
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08084941
38Retinol metabolism_Homo sapiens_hsa008301.07767840
39Chemical carcinogenesis_Homo sapiens_hsa052041.07544482
40Vibrio cholerae infection_Homo sapiens_hsa051101.06836090
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05236395
42Vitamin digestion and absorption_Homo sapiens_hsa049771.01389732
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.98510091
44N-Glycan biosynthesis_Homo sapiens_hsa005100.96829357
45Glycosaminoglycan degradation_Homo sapiens_hsa005310.96196242
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96015003
47Vitamin B6 metabolism_Homo sapiens_hsa007500.95241414
48TGF-beta signaling pathway_Homo sapiens_hsa043500.94736917
49Glutathione metabolism_Homo sapiens_hsa004800.94722651
50Tryptophan metabolism_Homo sapiens_hsa003800.94344130
51PPAR signaling pathway_Homo sapiens_hsa033200.93134334
52Basal transcription factors_Homo sapiens_hsa030220.93131099
53ECM-receptor interaction_Homo sapiens_hsa045120.92522956
54Malaria_Homo sapiens_hsa051440.88838863
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.86539162
56Fatty acid degradation_Homo sapiens_hsa000710.85892465
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85681811
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84836011
59Arachidonic acid metabolism_Homo sapiens_hsa005900.84664606
60Renal cell carcinoma_Homo sapiens_hsa052110.84559410
61Lysosome_Homo sapiens_hsa041420.82335189
62Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81750060
63Tight junction_Homo sapiens_hsa045300.80971304
64Mineral absorption_Homo sapiens_hsa049780.80162148
65ABC transporters_Homo sapiens_hsa020100.78699430
66beta-Alanine metabolism_Homo sapiens_hsa004100.78633006
67Phototransduction_Homo sapiens_hsa047440.78100175
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.74490657
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72834003
70Pyruvate metabolism_Homo sapiens_hsa006200.68952470
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68457275
72Parkinsons disease_Homo sapiens_hsa050120.68402277
73Autoimmune thyroid disease_Homo sapiens_hsa053200.68329729
74Non-homologous end-joining_Homo sapiens_hsa034500.68288918
75Ovarian steroidogenesis_Homo sapiens_hsa049130.68112716
76Tyrosine metabolism_Homo sapiens_hsa003500.67717006
77Fat digestion and absorption_Homo sapiens_hsa049750.67390641
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.64638514
79Arginine biosynthesis_Homo sapiens_hsa002200.64540367
80Starch and sucrose metabolism_Homo sapiens_hsa005000.64355543
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64183068
82Hippo signaling pathway_Homo sapiens_hsa043900.64032673
83Renin secretion_Homo sapiens_hsa049240.63615519
84Adherens junction_Homo sapiens_hsa045200.61882441
85Regulation of autophagy_Homo sapiens_hsa041400.61826766
86Folate biosynthesis_Homo sapiens_hsa007900.61777202
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61752510
88Rheumatoid arthritis_Homo sapiens_hsa053230.57391734
89Caffeine metabolism_Homo sapiens_hsa002320.56094232
90Bile secretion_Homo sapiens_hsa049760.55921501
91Hedgehog signaling pathway_Homo sapiens_hsa043400.51613002
92Glucagon signaling pathway_Homo sapiens_hsa049220.49257992
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46785150
94Endocytosis_Homo sapiens_hsa041440.46644302
95Dorso-ventral axis formation_Homo sapiens_hsa043200.46195909
96Ras signaling pathway_Homo sapiens_hsa040140.45677610
97Glycerolipid metabolism_Homo sapiens_hsa005610.45322265
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.44994213
99Phagosome_Homo sapiens_hsa041450.44895720
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44772839
101Oxidative phosphorylation_Homo sapiens_hsa001900.43674832
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.43411341
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42625438
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42145745
105Proteoglycans in cancer_Homo sapiens_hsa052050.42115747
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40953146
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40765864
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39808474
109Pancreatic secretion_Homo sapiens_hsa049720.39742725
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39733153
111Dilated cardiomyopathy_Homo sapiens_hsa054140.39361002
112p53 signaling pathway_Homo sapiens_hsa041150.38904884
113Prion diseases_Homo sapiens_hsa050200.38531804
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38518365
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37912051
116Renin-angiotensin system_Homo sapiens_hsa046140.37397292
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36685399
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.36596997
119One carbon pool by folate_Homo sapiens_hsa006700.36414703
120Phenylalanine metabolism_Homo sapiens_hsa003600.35410064
121Basal cell carcinoma_Homo sapiens_hsa052170.35348717
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34899051
123Metabolic pathways_Homo sapiens_hsa011000.33379404
124Focal adhesion_Homo sapiens_hsa045100.33114195
125Protein digestion and absorption_Homo sapiens_hsa049740.31987621
126Serotonergic synapse_Homo sapiens_hsa047260.30097302
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.28576464
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25549920
129Amoebiasis_Homo sapiens_hsa051460.24867796
130Prostate cancer_Homo sapiens_hsa052150.24519430
131Pertussis_Homo sapiens_hsa051330.24302945
132Alzheimers disease_Homo sapiens_hsa050100.24260801
133Long-term depression_Homo sapiens_hsa047300.24171518
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.24091965
135Other glycan degradation_Homo sapiens_hsa005110.21722448
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20457610
137ErbB signaling pathway_Homo sapiens_hsa040120.20407173

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