REEP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.90908794
2viral transcription (GO:0019083)4.56333849
3translational termination (GO:0006415)4.41169558
4protein localization to kinetochore (GO:0034501)4.29633445
5maturation of SSU-rRNA (GO:0030490)4.28331454
6protein localization to chromosome, centromeric region (GO:0071459)4.02124413
7translational elongation (GO:0006414)3.95959989
8ribosomal small subunit biogenesis (GO:0042274)3.86717005
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.79424120
10proline biosynthetic process (GO:0006561)3.78354652
11DNA strand elongation involved in DNA replication (GO:0006271)3.74837823
12cotranslational protein targeting to membrane (GO:0006613)3.67949549
13protein targeting to ER (GO:0045047)3.67367239
14Golgi transport vesicle coating (GO:0048200)3.64797163
15COPI coating of Golgi vesicle (GO:0048205)3.64797163
16translational initiation (GO:0006413)3.64195470
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63164000
18DNA unwinding involved in DNA replication (GO:0006268)3.62194407
19telomere maintenance via semi-conservative replication (GO:0032201)3.61485403
20DNA deamination (GO:0045006)3.59736373
21DNA strand elongation (GO:0022616)3.57492213
22negative regulation of erythrocyte differentiation (GO:0045647)3.57277338
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53430999
24cellular response to thyroid hormone stimulus (GO:0097067)3.50905113
25viral life cycle (GO:0019058)3.50508177
26formation of translation preinitiation complex (GO:0001731)3.50301642
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47793271
28protein localization to endoplasmic reticulum (GO:0070972)3.42168582
29cellular protein complex disassembly (GO:0043624)3.40626895
30mitotic sister chromatid segregation (GO:0000070)3.37848603
31ribosomal large subunit biogenesis (GO:0042273)3.37648774
32mitotic nuclear envelope disassembly (GO:0007077)3.29620608
33DNA replication initiation (GO:0006270)3.27866463
34pentose-phosphate shunt (GO:0006098)3.24255315
35response to thyroid hormone (GO:0097066)3.19846205
36CENP-A containing nucleosome assembly (GO:0034080)3.18152740
37telomere maintenance via recombination (GO:0000722)3.17331997
38kinetochore organization (GO:0051383)3.14443519
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13962799
40mitotic metaphase plate congression (GO:0007080)3.12072005
41chromatin remodeling at centromere (GO:0031055)3.11205089
42response to peptidoglycan (GO:0032494)3.10781344
43protein complex disassembly (GO:0043241)3.09367087
44nuclear envelope disassembly (GO:0051081)3.06681957
45membrane disassembly (GO:0030397)3.06681957
46sister chromatid segregation (GO:0000819)3.06218815
47positive regulation of gamma-delta T cell activation (GO:0046645)3.05940239
48mitotic recombination (GO:0006312)3.04288463
49regulation of spindle organization (GO:0090224)3.01859939
50positive regulation by organism of defense response of other organism involved in symbiotic interact2.99046892
51modulation by symbiont of host immune response (GO:0052553)2.99046892
52positive regulation by symbiont of host defense response (GO:0052509)2.99046892
53modulation by symbiont of host defense response (GO:0052031)2.99046892
54modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99046892
55modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99046892
56interferon-gamma secretion (GO:0072643)2.96902933
57ribonucleoprotein complex biogenesis (GO:0022613)2.96470539
58protein maturation by protein folding (GO:0022417)2.93303747
59regulation of superoxide anion generation (GO:0032928)2.91679170
60mannose metabolic process (GO:0006013)2.91520565
61deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90836925
62mitotic chromosome condensation (GO:0007076)2.90108494
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.88853884
64antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88806510
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88806510
66folic acid-containing compound biosynthetic process (GO:0009396)2.88112234
67macromolecular complex disassembly (GO:0032984)2.87535812
68tolerance induction (GO:0002507)2.87434204
69DNA replication-independent nucleosome organization (GO:0034724)2.87024764
70DNA replication-independent nucleosome assembly (GO:0006336)2.87024764
71attachment of spindle microtubules to kinetochore (GO:0008608)2.86313285
72GDP-mannose metabolic process (GO:0019673)2.85530235
73kinetochore assembly (GO:0051382)2.83638176
74metaphase plate congression (GO:0051310)2.83486496
75pinocytosis (GO:0006907)2.82573071
76nuclear-transcribed mRNA catabolic process (GO:0000956)2.82493166
77platelet formation (GO:0030220)2.81527284
78negative regulation of B cell apoptotic process (GO:0002903)2.81338357
79establishment of chromosome localization (GO:0051303)2.79928750
80positive regulation of osteoblast proliferation (GO:0033690)2.79822189
81telomere maintenance via telomere lengthening (GO:0010833)2.79436413
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.77288037
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73532090
84NADPH regeneration (GO:0006740)2.73275755
85pentose metabolic process (GO:0019321)2.71263121
86glucose catabolic process (GO:0006007)2.70758438
87DNA replication checkpoint (GO:0000076)2.70677589
88mRNA catabolic process (GO:0006402)2.70459233
89apoptotic process involved in morphogenesis (GO:0060561)2.70240214
90positive regulation of Cdc42 GTPase activity (GO:0043089)2.70095060
91RNA catabolic process (GO:0006401)2.65382821
92granulocyte differentiation (GO:0030851)2.63915484
93desmosome organization (GO:0002934)2.62837776
94neutrophil activation involved in immune response (GO:0002283)2.62205142
95mitochondrial calcium ion transport (GO:0006851)2.61945144
96regulation of defense response to virus by virus (GO:0050690)2.61359589
97regulation of mast cell degranulation (GO:0043304)2.59446692
98protein localization to endosome (GO:0036010)2.59105462
99modulation by virus of host process (GO:0019054)2.58996316
100translation (GO:0006412)2.58539979
101negative regulation of RNA splicing (GO:0033119)2.58195573
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.57767044
103maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57357948
104protein localization to chromosome (GO:0034502)2.57277477
105nucleobase biosynthetic process (GO:0046112)2.56298202
106rRNA processing (GO:0006364)2.54550428
107regulation of apoptotic process involved in morphogenesis (GO:1902337)2.53790659
108ribosome biogenesis (GO:0042254)2.52530201
109regulation of leukocyte degranulation (GO:0043300)2.48169674
110meiotic chromosome segregation (GO:0045132)2.47761613
111adenine nucleotide transport (GO:0051503)2.47498642
112glucose 6-phosphate metabolic process (GO:0051156)2.47381727
113histone exchange (GO:0043486)2.47238557
1143-UTR-mediated mRNA stabilization (GO:0070935)2.46826886
115rRNA metabolic process (GO:0016072)2.46724216
116cellular response to virus (GO:0098586)2.46027526
117pyrimidine nucleoside salvage (GO:0043097)2.45183229
118pyrimidine-containing compound salvage (GO:0008655)2.45183229
119protein retention in ER lumen (GO:0006621)2.44759370
120response to muramyl dipeptide (GO:0032495)2.44672452
121peptidyl-arginine omega-N-methylation (GO:0035247)2.44608917
122spindle checkpoint (GO:0031577)2.44425551
123negative regulation of chromosome segregation (GO:0051985)2.44132817
124DNA replication-dependent nucleosome assembly (GO:0006335)2.43829915
125DNA replication-dependent nucleosome organization (GO:0034723)2.43829915
126modulation by symbiont of host cellular process (GO:0044068)2.43541114
127IMP biosynthetic process (GO:0006188)2.43334523
128* nuclear envelope organization (GO:0006998)2.42991098
129pseudouridine synthesis (GO:0001522)2.42703300
130regulation of mitotic spindle organization (GO:0060236)2.42615510
131anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.42609262
132regulation of chromosome segregation (GO:0051983)2.42447985
133NIK/NF-kappaB signaling (GO:0038061)2.42381565
134protein targeting to membrane (GO:0006612)2.41958705
135negative regulation of sister chromatid segregation (GO:0033046)2.40677100
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.40677100
137negative regulation of mitotic sister chromatid segregation (GO:0033048)2.40677100
138negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.40677100
139Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40462805
140amino sugar catabolic process (GO:0046348)2.40405177
141hemidesmosome assembly (GO:0031581)2.40289391
142antigen processing and presentation of endogenous antigen (GO:0019883)2.39973587
143negative regulation of myeloid cell apoptotic process (GO:0033033)2.39808586
144spindle assembly checkpoint (GO:0071173)2.38626293
145epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38471585
146activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.38178857
147chromatin assembly or disassembly (GO:0006333)2.38089129
148spliceosomal tri-snRNP complex assembly (GO:0000244)2.37794562
149DNA duplex unwinding (GO:0032508)2.37536238
150regulation of B cell apoptotic process (GO:0002902)2.37369079
151negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.37036315
152negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.36332078
153DNA geometric change (GO:0032392)2.35746812
154negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.35639525
155mitotic spindle assembly checkpoint (GO:0007094)2.34971413
156regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.34420153
157T cell apoptotic process (GO:0070231)2.34147576
158basement membrane organization (GO:0071711)2.33358755
159antigen processing and presentation via MHC class Ib (GO:0002475)2.33277696
160regulation of myeloid leukocyte mediated immunity (GO:0002886)2.32021269
161purine ribonucleotide transport (GO:0015868)2.31869859
162proline metabolic process (GO:0006560)2.31565075
163chromosome segregation (GO:0007059)2.30962961
164regulation of water loss via skin (GO:0033561)2.30525509
165immunoglobulin mediated immune response (GO:0016064)2.29186322
166nuclear pore complex assembly (GO:0051292)2.29121026
167chromosome condensation (GO:0030261)2.29098528
168activation of Rac GTPase activity (GO:0032863)2.28674327
169detection of bacterium (GO:0016045)2.26158339
170erythrocyte development (GO:0048821)2.22252652
171regulation of interferon-beta biosynthetic process (GO:0045357)2.21094284
172viral mRNA export from host cell nucleus (GO:0046784)2.20875874
173chaperone mediated protein folding requiring cofactor (GO:0051085)2.20849349
174regulation of translational termination (GO:0006449)2.20570586
175negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.19837703
176negative regulation of DNA-templated transcription, elongation (GO:0032785)2.19716423
177regulation of mast cell activation involved in immune response (GO:0033006)2.17531027
178retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.17263568
179* nuclear envelope reassembly (GO:0031468)2.15439434
180* mitotic nuclear envelope reassembly (GO:0007084)2.15439434
181nucleobase-containing small molecule interconversion (GO:0015949)2.15371418
182detection of other organism (GO:0098543)2.15108681
183glycosphingolipid catabolic process (GO:0046479)2.14583416
184snRNA metabolic process (GO:0016073)2.13291978
185negative regulation of toll-like receptor signaling pathway (GO:0034122)2.08750394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.70100032
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.26822071
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.52050169
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.34522848
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.21665988
6* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00250287
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85791101
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.55068269
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.31701389
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25053390
11MYC_22102868_ChIP-Seq_BL_Human2.20327439
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18892557
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12259482
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06898551
15LXR_22292898_ChIP-Seq_THP-1_Human2.04282690
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.02750293
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.95720818
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.94350998
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93729152
20XRN2_22483619_ChIP-Seq_HELA_Human1.92670671
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90024562
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89355100
23ZNF263_19887448_ChIP-Seq_K562_Human1.87760570
24* VDR_21846776_ChIP-Seq_THP-1_Human1.86696390
25AR_21909140_ChIP-Seq_LNCAP_Human1.86203194
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81931007
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78327658
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78302465
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74551187
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74369444
31RACK7_27058665_Chip-Seq_MCF-7_Human1.70542164
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68613576
33VDR_23849224_ChIP-Seq_CD4+_Human1.67855953
34TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64678493
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58387067
36DCP1A_22483619_ChIP-Seq_HELA_Human1.57290635
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.56896102
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.54886501
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53346197
40FOXP3_21729870_ChIP-Seq_TREG_Human1.52501327
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51389233
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50330327
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49367149
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49266347
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48575681
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.44496206
47CIITA_25753668_ChIP-Seq_RAJI_Human1.43236280
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42808337
49TTF2_22483619_ChIP-Seq_HELA_Human1.41388937
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41106279
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39799013
52SPI1_23547873_ChIP-Seq_NB4_Human1.38916114
53NCOR1_26117541_ChIP-Seq_K562_Human1.38659164
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38615875
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38118915
56* GABP_19822575_ChIP-Seq_HepG2_Human1.37818314
57* P68_20966046_ChIP-Seq_HELA_Human1.36891341
58SCL_19346495_ChIP-Seq_HPC-7_Human1.36582588
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35534084
60KDM2B_26808549_Chip-Seq_DND41_Human1.34560238
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33804286
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32145322
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.31988058
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31857821
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30273380
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29861571
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29789889
68MAF_26560356_Chip-Seq_TH1_Human1.27179436
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26629890
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.26118690
71SA1_27219007_Chip-Seq_ERYTHROID_Human1.25870725
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.24335053
73CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24122957
74BCOR_27268052_Chip-Seq_Bcells_Human1.23798673
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22690545
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20953905
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20077290
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18940646
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18571327
80UTX_26944678_Chip-Seq_JUKART_Human1.18266829
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18126008
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17061593
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16397930
84KDM5A_27292631_Chip-Seq_BREAST_Human1.15772313
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.15238977
86BCL6_27268052_Chip-Seq_Bcells_Human1.14978079
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14936744
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.13880332
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13721689
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12560624
91ELK1_19687146_ChIP-ChIP_HELA_Human1.10696673
92MYB_26560356_Chip-Seq_TH2_Human1.10684580
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10479201
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09927769
95VDR_24763502_ChIP-Seq_THP-1_Human1.09622654
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09605180
97STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09497844
98MYB_26560356_Chip-Seq_TH1_Human1.08638527
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08374374
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07782993
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.07289568
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07102041
103TFEB_21752829_ChIP-Seq_HELA_Human1.06581536
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06007820
105CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06003150
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05903538
107PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05816419
108TCF7_22412390_ChIP-Seq_EML_Mouse1.05764144
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05591219
110YY1_21170310_ChIP-Seq_MESCs_Mouse1.05430206
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04989381
112GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04726734
113CTCF_26484167_Chip-Seq_Bcells_Mouse1.04650406
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03561076
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03552498
116IRF8_21731497_ChIP-ChIP_J774_Mouse1.02718584
117* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02451435
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02277872
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01742587
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01561394
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01467378
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99240097
123MAF_26560356_Chip-Seq_TH2_Human0.97637631
124GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95952849
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95288807
126THAP11_20581084_ChIP-Seq_MESCs_Mouse0.94968922
127SRF_21415370_ChIP-Seq_HL-1_Mouse0.93437465
128* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92739289
129* ATF3_27146783_Chip-Seq_COLON_Human0.90019571
130* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89697637
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86814431
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85274299
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85263435
134NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84707895
135CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84290371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.33805653
2MP0005058_abnormal_lysosome_morphology3.50128637
3MP0003111_abnormal_nucleus_morphology3.00419770
4MP0004957_abnormal_blastocyst_morpholog2.95244117
5MP0010094_abnormal_chromosome_stability2.76458564
6MP0003077_abnormal_cell_cycle2.62356833
7MP0002396_abnormal_hematopoietic_system2.43403323
8MP0008260_abnormal_autophagy2.38359301
9MP0010352_gastrointestinal_tract_polyps2.34972408
10MP0008007_abnormal_cellular_replicative2.14735888
11MP0003191_abnormal_cellular_cholesterol2.13745932
12MP0005451_abnormal_body_composition2.06439536
13MP0000490_abnormal_crypts_of2.05815374
14MP0009840_abnormal_foam_cell2.00854923
15MP0003763_abnormal_thymus_physiology1.99115941
16MP0003172_abnormal_lysosome_physiology1.89520520
17MP0002796_impaired_skin_barrier1.80152540
18MP0008057_abnormal_DNA_replication1.78259388
19MP0005501_abnormal_skin_physiology1.69082747
20MP0001835_abnormal_antigen_presentation1.68573687
21MP0009333_abnormal_splenocyte_physiolog1.68300928
22MP0000685_abnormal_immune_system1.66137656
23MP0006054_spinal_hemorrhage1.63086840
24MP0003436_decreased_susceptibility_to1.62561525
25MP0004808_abnormal_hematopoietic_stem1.62293300
26MP0000383_abnormal_hair_follicle1.62121865
27MP0005397_hematopoietic_system_phenotyp1.61128208
28MP0001545_abnormal_hematopoietic_system1.61128208
29MP0008058_abnormal_DNA_repair1.60589200
30MP0004947_skin_inflammation1.60240291
31MP0010234_abnormal_vibrissa_follicle1.48989173
32MP0004264_abnormal_extraembryonic_tissu1.48387945
33MP0002398_abnormal_bone_marrow1.48332844
34MP0001216_abnormal_epidermal_layer1.46588026
35MP0001661_extended_life_span1.44717011
36MP0003806_abnormal_nucleotide_metabolis1.44382324
37MP0010307_abnormal_tumor_latency1.44133190
38MP0008932_abnormal_embryonic_tissue1.43170009
39MP0003705_abnormal_hypodermis_morpholog1.41770886
40MP0002060_abnormal_skin_morphology1.41487799
41MP0005275_abnormal_skin_tensile1.40424557
42MP0010155_abnormal_intestine_physiology1.40011384
43MP0009785_altered_susceptibility_to1.39587531
44MP0002722_abnormal_immune_system1.37509375
45MP0003566_abnormal_cell_adhesion1.36306505
46MP0001800_abnormal_humoral_immune1.36096542
47MP0000858_altered_metastatic_potential1.35562400
48MP0000350_abnormal_cell_proliferation1.35134446
49MP0002019_abnormal_tumor_incidence1.34936003
50MP0005023_abnormal_wound_healing1.34535974
51MP0000465_gastrointestinal_hemorrhage1.31772820
52MP0003786_premature_aging1.31519871
53MP0001730_embryonic_growth_arrest1.30096345
54MP0000689_abnormal_spleen_morphology1.28533970
55MP0005025_abnormal_response_to1.28063844
56MP0000678_abnormal_parathyroid_gland1.27831887
57MP0002098_abnormal_vibrissa_morphology1.27059995
58MP0000703_abnormal_thymus_morphology1.26917714
59MP0005083_abnormal_biliary_tract1.25933936
60MP0002452_abnormal_antigen_presenting1.24500051
61MP0003453_abnormal_keratinocyte_physiol1.24394245
62MP0002420_abnormal_adaptive_immunity1.24360381
63MP0005671_abnormal_response_to1.23930825
64MP0004185_abnormal_adipocyte_glucose1.23538369
65MP0002405_respiratory_system_inflammati1.23034161
66MP0001819_abnormal_immune_cell1.22831211
67MP0005076_abnormal_cell_differentiation1.20911806
68MP0000377_abnormal_hair_follicle1.19405152
69MP0005000_abnormal_immune_tolerance1.18935387
70MP0002429_abnormal_blood_cell1.17950781
71MP0002723_abnormal_immune_serum1.17680252
72MP0010678_abnormal_skin_adnexa1.17070005
73MP0002166_altered_tumor_susceptibility1.16822129
74MP0000716_abnormal_immune_system1.16786260
75MP0000015_abnormal_ear_pigmentation1.15071424
76MP0000313_abnormal_cell_death1.11277281
77MP0002132_abnormal_respiratory_system1.09974347
78MP0001243_abnormal_dermal_layer1.09219430
79MP0009278_abnormal_bone_marrow1.08434181
80MP0001853_heart_inflammation1.08253052
81MP0001533_abnormal_skeleton_physiology1.07847955
82MP0002006_tumorigenesis1.06133648
83MP0001873_stomach_inflammation1.04261609
84MP0001790_abnormal_immune_system1.03808555
85MP0005387_immune_system_phenotype1.03808555
86MP0003866_abnormal_defecation1.03431487
87MP0005360_urolithiasis1.01705821
88MP0004858_abnormal_nervous_system1.01700798
89MP0004381_abnormal_hair_follicle1.01453974
90MP0005464_abnormal_platelet_physiology1.01041192
91MP0002148_abnormal_hypersensitivity_rea0.99698002
92MP0009931_abnormal_skin_appearance0.98036877
93MP0005408_hypopigmentation0.97086197
94MP0002419_abnormal_innate_immunity0.96934258
95MP0002080_prenatal_lethality0.95916522
96MP0010030_abnormal_orbit_morphology0.95180435
97MP0000477_abnormal_intestine_morphology0.95031571
98MP0004782_abnormal_surfactant_physiolog0.94557248
99MP0001697_abnormal_embryo_size0.93807789
100MP0008469_abnormal_protein_level0.93276012
101MP0010771_integument_phenotype0.89760402
102MP0005174_abnormal_tail_pigmentation0.88174288
103MP0002086_abnormal_extraembryonic_tissu0.87343027
104MP0003941_abnormal_skin_development0.86555658
105MP0001191_abnormal_skin_condition0.86006717
106MP0001851_eye_inflammation0.85691247
107MP0003300_gastrointestinal_ulcer0.85441190
108MP0005380_embryogenesis_phenotype0.84851654
109MP0001672_abnormal_embryogenesis/_devel0.84851654
110MP0001845_abnormal_inflammatory_respons0.84524655
111MP0000371_diluted_coat_color0.83360876
112MP0003448_altered_tumor_morphology0.83112544
113MP0004233_abnormal_muscle_weight0.82368466
114MP0006082_CNS_inflammation0.80883969
115MP0000579_abnormal_nail_morphology0.79651036
116MP0002254_reproductive_system_inflammat0.79408286
117MP0006036_abnormal_mitochondrial_physio0.78841269
118MP0000358_abnormal_cell_content/0.78295386
119MP0002877_abnormal_melanocyte_morpholog0.78090035
120MP0003303_peritoneal_inflammation0.77949080
121MP0003984_embryonic_growth_retardation0.77688715
122MP0000467_abnormal_esophagus_morphology0.77576820
123MP0000537_abnormal_urethra_morphology0.77204209
124MP0000343_altered_response_to0.77151018
125MP0003656_abnormal_erythrocyte_physiolo0.76339611
126MP0002088_abnormal_embryonic_growth/wei0.75890443
127MP0001849_ear_inflammation0.75246066
128MP0005075_abnormal_melanosome_morpholog0.74336942

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.74729101
2Abnormal number of erythroid precursors (HP:0012131)4.54708980
3Reticulocytopenia (HP:0001896)4.46818210
4Abnormality of glycolipid metabolism (HP:0010969)3.47614135
5Abnormality of liposaccharide metabolism (HP:0010968)3.47614135
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.47614135
7Pallor (HP:0000980)3.22565626
8Increased cerebral lipofuscin (HP:0011813)3.19185364
9Selective tooth agenesis (HP:0001592)3.19184803
10Short middle phalanx of the 5th finger (HP:0004220)3.06756369
11Reticulocytosis (HP:0001923)3.02354983
12Increased neuronal autofluorescent lipopigment (HP:0002074)2.98831859
13Thrombocytosis (HP:0001894)2.95531809
14Macrocytic anemia (HP:0001972)2.75728550
15Chronic otitis media (HP:0000389)2.74140915
16Oral leukoplakia (HP:0002745)2.73509565
17Increased IgE level (HP:0003212)2.73108627
18Aplastic anemia (HP:0001915)2.68496119
19Poikiloderma (HP:0001029)2.67058249
20Elevated erythrocyte sedimentation rate (HP:0003565)2.65251969
21Nasal polyposis (HP:0100582)2.64421373
22Ragged-red muscle fibers (HP:0003200)2.64279444
23Petechiae (HP:0000967)2.62805659
24Dysostosis multiplex (HP:0000943)2.59265083
25Abnormality of macrophages (HP:0004311)2.57912780
26Vertebral compression fractures (HP:0002953)2.57552674
27Hypertensive crisis (HP:0100735)2.56279585
28Pustule (HP:0200039)2.54597809
29Abnormality of the nasal mucosa (HP:0000433)2.53981359
30Microretrognathia (HP:0000308)2.51416542
3111 pairs of ribs (HP:0000878)2.47073927
32Onycholysis (HP:0001806)2.46774440
33IgM deficiency (HP:0002850)2.44926541
34Polycythemia (HP:0001901)2.43468681
35Myositis (HP:0100614)2.41806373
36Entropion (HP:0000621)2.40050522
37Vacuolated lymphocytes (HP:0001922)2.39726093
38Trismus (HP:0000211)2.38447732
39Eczematoid dermatitis (HP:0000976)2.34343342
40Absent thumb (HP:0009777)2.32685941
41Cholecystitis (HP:0001082)2.29918539
42Abnormal gallbladder physiology (HP:0012438)2.29918539
43Abnormal platelet function (HP:0011869)2.27680185
44Impaired platelet aggregation (HP:0003540)2.27680185
45Mediastinal lymphadenopathy (HP:0100721)2.26245560
46Rough bone trabeculation (HP:0100670)2.25389068
47Gastrointestinal stroma tumor (HP:0100723)2.22599573
48Myelodysplasia (HP:0002863)2.21755133
49Cellulitis (HP:0100658)2.21205749
50Blepharitis (HP:0000498)2.21157793
51Hepatosplenomegaly (HP:0001433)2.20467578
52Abnormality of the preputium (HP:0100587)2.19630229
53Milia (HP:0001056)2.19024685
54Esophageal neoplasm (HP:0100751)2.18637154
55Neoplasm of head and neck (HP:0012288)2.18637154
56Abnormality of the distal phalanges of the toes (HP:0010182)2.18407651
57Obstructive lung disease (HP:0006536)2.18203470
58Chronic obstructive pulmonary disease (HP:0006510)2.18203470
59Basal cell carcinoma (HP:0002671)2.17863760
60Woolly hair (HP:0002224)2.17527325
61Nonimmune hydrops fetalis (HP:0001790)2.17118455
62Polygenic inheritance (HP:0010982)2.14402114
63Loss of speech (HP:0002371)2.13850324
64Recurrent bronchitis (HP:0002837)2.13251213
65Squamous cell carcinoma (HP:0002860)2.12533747
66Pili torti (HP:0003777)2.11298316
67Abnormality of reticulocytes (HP:0004312)2.10897610
68Abnormality of T cell physiology (HP:0011840)2.07862425
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06661702
70Achilles tendon contracture (HP:0001771)2.06608466
71Erythema (HP:0010783)2.06603974
72Sparse eyelashes (HP:0000653)2.06430478
73Chromsome breakage (HP:0040012)2.05230378
74Progressive muscle weakness (HP:0003323)2.03399392
75Agnosia (HP:0010524)2.03345651
76Fragile nails (HP:0001808)2.02473276
77Carpal bone hypoplasia (HP:0001498)2.01870376
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.01145133
79Abnormality of the heme biosynthetic pathway (HP:0010472)1.99752917
80Recurrent viral infections (HP:0004429)1.99673074
81Colon cancer (HP:0003003)1.99297927
82Abnormality of T cells (HP:0002843)1.99041219
83Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98269168
84Skin ulcer (HP:0200042)1.98142135
85Thin bony cortex (HP:0002753)1.95627719
86Breast hypoplasia (HP:0003187)1.95345527
87Testicular atrophy (HP:0000029)1.94133935
88Abnormal hair laboratory examination (HP:0003328)1.93903367
89Small intestinal stenosis (HP:0012848)1.93569346
90Duodenal stenosis (HP:0100867)1.93569346
91Nail dystrophy (HP:0008404)1.93259524
92Abnormal blistering of the skin (HP:0008066)1.92987098
93Urticaria (HP:0001025)1.92364526
94Recurrent abscess formation (HP:0002722)1.92254669
95Birth length less than 3rd percentile (HP:0003561)1.91263511
96Distal lower limb muscle weakness (HP:0009053)1.91130259
97Plantar hyperkeratosis (HP:0007556)1.90210150
98Lymphoma (HP:0002665)1.90172593
99Abnormality of the anterior horn cell (HP:0006802)1.86549770
100Degeneration of anterior horn cells (HP:0002398)1.86549770
101Hyperacusis (HP:0010780)1.86200334
102Seborrheic dermatitis (HP:0001051)1.86113864
103Recurrent fungal infections (HP:0002841)1.85226332
104Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85187083
105Granulocytopenia (HP:0001913)1.84524212
106Broad distal phalanx of finger (HP:0009836)1.84342072
107Deep palmar crease (HP:0006191)1.83395765
108J-shaped sella turcica (HP:0002680)1.80889258
109Long palpebral fissure (HP:0000637)1.80681389
110Hypotrichosis (HP:0001006)1.80467831
111Autoimmune thrombocytopenia (HP:0001973)1.79975104
112Premature ovarian failure (HP:0008209)1.79606408
113Alopecia of scalp (HP:0002293)1.79129418
114Abnormality of nail color (HP:0100643)1.79018911
115Neoplasm of the pancreas (HP:0002894)1.78914680
116Progressive neurologic deterioration (HP:0002344)1.78761700
117Diaphragmatic weakness (HP:0009113)1.78047037
118Thick nail (HP:0001805)1.75602665
119Thoracic kyphosis (HP:0002942)1.75291425
120Abnormality of the Achilles tendon (HP:0005109)1.75077626
121Orchitis (HP:0100796)1.74844558
122Axonal loss (HP:0003447)1.74697666
123Elbow flexion contracture (HP:0002987)1.73267398
124Acanthocytosis (HP:0001927)1.72305249
125Short 5th finger (HP:0009237)1.71907664
126Fragile skin (HP:0001030)1.71901144
127Abnormality of DNA repair (HP:0003254)1.70472558
128Bone marrow hypocellularity (HP:0005528)1.69553787
129Spontaneous hematomas (HP:0007420)1.69444556
130Ectropion (HP:0000656)1.68757655
131Premature rupture of membranes (HP:0001788)1.68324515
132Abnormality of chromosome stability (HP:0003220)1.68075555
133Abnormal trabecular bone morphology (HP:0100671)1.68059842
134Premature graying of hair (HP:0002216)1.67174396
135Meckel diverticulum (HP:0002245)1.66610750
136Abnormality of the thoracic spine (HP:0100711)1.66498581
137Orthostatic hypotension (HP:0001278)1.66445722
138Interstitial pulmonary disease (HP:0006530)1.65264811
139Multiple enchondromatosis (HP:0005701)1.64481368
140Recurrent bacterial skin infections (HP:0005406)1.64205528
141Prolonged bleeding time (HP:0003010)1.62863596
142B lymphocytopenia (HP:0010976)1.61755526
143Abnormality of B cell number (HP:0010975)1.61755526
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.61540589
145Aplasia/Hypoplasia of the thymus (HP:0010515)1.61332738
146Abnormality of mucopolysaccharide metabolism (HP:0011020)1.60676179
147Abnormality of polysaccharide metabolism (HP:0011012)1.60676179
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.60676179
149Abnormality of the ileum (HP:0001549)1.60538478
150Abnormality of the duodenum (HP:0002246)1.60047777
151Increased serum ferritin (HP:0003281)1.58955955
152Recurrent skin infections (HP:0001581)1.58954349
153Cheilitis (HP:0100825)1.58555213
154Gastrointestinal inflammation (HP:0004386)1.58402763
155Amaurosis fugax (HP:0100576)1.58337328
156Eosinophilia (HP:0001880)1.58197254
157High pitched voice (HP:0001620)1.57549354
158Combined immunodeficiency (HP:0005387)1.56957535
159T lymphocytopenia (HP:0005403)1.56767913
160Microvesicular hepatic steatosis (HP:0001414)1.56432258
161Flat acetabular roof (HP:0003180)1.56138124
162Bronchitis (HP:0012387)1.55822252
163Ectopic kidney (HP:0000086)1.54570007
164Reduced subcutaneous adipose tissue (HP:0003758)1.53865848
165Increased density of long bones (HP:0006392)1.53777240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.43052231
2SMG13.12999969
3WEE12.75993703
4NME22.71598514
5MAP4K12.67987964
6NEK22.64550984
7STK102.33989646
8PRPF4B2.29735768
9ERN12.26923269
10EEF2K2.17530597
11MAP3K102.14152297
12CDC72.13481383
13RPS6KB22.05078613
14ARAF2.04706591
15RPS6KA41.98246806
16SIK11.94289368
17EPHA21.86238151
18VRK21.76878237
19TESK21.76343966
20PIM21.57624348
21ICK1.56048464
22TESK11.55740129
23TTK1.55623404
24MAP3K111.55345612
25LRRK21.51972553
26ACVR1B1.51513000
27BRSK21.51164263
28FLT31.50845069
29MAP3K131.47465328
30KDR1.46921518
31STK161.45094078
32MAP3K81.42471309
33EIF2AK11.42161690
34AURKB1.41929968
35BRAF1.41615935
36BTK1.37578477
37PKN21.35324714
38MST1R1.34685347
39PAK41.33781755
40ZAP701.33768155
41DYRK31.33587943
42BLK1.32490250
43CDK71.31195557
44RIPK41.28437087
45TGFBR11.25180440
46MAPKAPK31.22737951
47MAP3K31.21657738
48CDK41.20691804
49TRIB31.19557071
50PLK11.18516950
51PASK1.18122444
52KIT1.14882028
53STK41.13520059
54SRPK11.13000942
55TYK21.12033837
56CDK81.09607171
57ATR1.09507351
58MAP2K31.07216949
59PDK21.05829513
60AURKA1.04460126
61PLK41.04294351
62SCYL20.98131653
63CDK120.96811686
64JAK30.95531452
65TEC0.93455327
66MST40.93374559
67MAP3K10.92941156
68FGFR40.91028088
69PIM10.90104809
70EIF2AK30.90071246
71EPHB10.89294005
72BRSK10.89286994
73PRKD20.87845708
74BCKDK0.86229144
75TBK10.83846843
76GRK60.83185329
77VRK10.83005355
78CDK60.81528504
79KSR20.81137864
80CSK0.79378114
81TGFBR20.77808086
82MAP3K140.77145819
83CHEK20.74797184
84CSF1R0.72046964
85TAOK10.70797559
86BMX0.69725190
87NEK10.69662915
88TXK0.68179625
89IRAK40.68072899
90MTOR0.62612349
91PDPK10.61356014
92MOS0.60701410
93PAK10.60310324
94CHEK10.60266973
95TLK10.60122702
96MAPKAPK20.59960892
97EIF2AK20.59536594
98MAP3K60.59342190
99MARK30.58339360
100ABL20.57854016
101IRAK30.57701901
102IKBKB0.57323179
103PTK60.56240939
104MATK0.56202523
105MAP3K90.55958627
106SIK30.55664445
107IKBKE0.55450181
108SYK0.55024528
109CLK10.54822369
110MAP2K20.54566124
111TSSK60.53784519
112PRKCI0.52275581
113CDC42BPA0.51161102
114STK30.50431809
115PTK20.49250100
116RPS6KC10.48991115
117RPS6KL10.48991115
118MKNK10.48604477
119LCK0.48475754
120TAOK20.47955180
121TNK20.47519378
122ITK0.45591896
123NLK0.44846078
124RPS6KA20.44763910
125LYN0.44264312
126PRKD30.44119814
127MAPK110.43833330
128RAF10.43678993
129TTN0.43470813
130CHUK0.42025471
131PRKG20.41987904
132NEK90.41627908
133ATM0.41469044
134ILK0.40394037
135IRAK20.39174074
136PBK0.38208808
137RPS6KA50.37916509
138HCK0.37083393
139CDK20.36719345

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22998279
2Ribosome_Homo sapiens_hsa030103.78353286
3Mismatch repair_Homo sapiens_hsa034303.17870718
4Base excision repair_Homo sapiens_hsa034102.72245977
5Homologous recombination_Homo sapiens_hsa034402.49188106
6Spliceosome_Homo sapiens_hsa030402.47270204
7Proteasome_Homo sapiens_hsa030502.40086504
8Cell cycle_Homo sapiens_hsa041102.37641298
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.31746309
10RNA transport_Homo sapiens_hsa030132.16957774
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16345271
12Nucleotide excision repair_Homo sapiens_hsa034202.12108237
13Fructose and mannose metabolism_Homo sapiens_hsa000511.97301762
14Pyrimidine metabolism_Homo sapiens_hsa002401.91681337
15Lysosome_Homo sapiens_hsa041421.90625704
16p53 signaling pathway_Homo sapiens_hsa041151.90272782
17RNA polymerase_Homo sapiens_hsa030201.82881611
18One carbon pool by folate_Homo sapiens_hsa006701.81565375
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81427119
20Fanconi anemia pathway_Homo sapiens_hsa034601.67226507
21Antigen processing and presentation_Homo sapiens_hsa046121.58706920
22Primary immunodeficiency_Homo sapiens_hsa053401.55207593
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53646217
24Non-homologous end-joining_Homo sapiens_hsa034501.53134211
25Biosynthesis of amino acids_Homo sapiens_hsa012301.41125779
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40792358
27Herpes simplex infection_Homo sapiens_hsa051681.40038156
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.39507795
29RNA degradation_Homo sapiens_hsa030181.29476283
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.27149167
31Legionellosis_Homo sapiens_hsa051341.23793236
32Non-small cell lung cancer_Homo sapiens_hsa052231.22101341
33Basal transcription factors_Homo sapiens_hsa030221.18836969
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.16192563
35Pentose phosphate pathway_Homo sapiens_hsa000301.15705317
36Sulfur relay system_Homo sapiens_hsa041221.14795877
37Hematopoietic cell lineage_Homo sapiens_hsa046401.10879276
38Epstein-Barr virus infection_Homo sapiens_hsa051691.09651451
39Measles_Homo sapiens_hsa051621.07637689
40Apoptosis_Homo sapiens_hsa042101.04391103
41Viral carcinogenesis_Homo sapiens_hsa052031.04345491
42HTLV-I infection_Homo sapiens_hsa051661.01950232
43Leishmaniasis_Homo sapiens_hsa051401.01441895
44Shigellosis_Homo sapiens_hsa051311.00924575
45Carbon metabolism_Homo sapiens_hsa012001.00842561
46Small cell lung cancer_Homo sapiens_hsa052220.99699810
47mRNA surveillance pathway_Homo sapiens_hsa030150.97844664
48Systemic lupus erythematosus_Homo sapiens_hsa053220.95327674
49VEGF signaling pathway_Homo sapiens_hsa043700.93279517
50Prion diseases_Homo sapiens_hsa050200.91854810
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.91747217
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90303772
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90156108
54Folate biosynthesis_Homo sapiens_hsa007900.89720333
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88951541
56Acute myeloid leukemia_Homo sapiens_hsa052210.86685840
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82927054
58Selenocompound metabolism_Homo sapiens_hsa004500.81699026
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80095677
60Influenza A_Homo sapiens_hsa051640.78289428
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76611804
62Purine metabolism_Homo sapiens_hsa002300.76531525
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76451163
64Thyroid cancer_Homo sapiens_hsa052160.75087088
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75026321
66Other glycan degradation_Homo sapiens_hsa005110.74362193
67Vibrio cholerae infection_Homo sapiens_hsa051100.74333895
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.73844470
69Toxoplasmosis_Homo sapiens_hsa051450.73740040
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.73105325
71Chronic myeloid leukemia_Homo sapiens_hsa052200.72129835
72Bladder cancer_Homo sapiens_hsa052190.71796065
73Hepatitis B_Homo sapiens_hsa051610.71740149
74B cell receptor signaling pathway_Homo sapiens_hsa046620.71196675
75Glutathione metabolism_Homo sapiens_hsa004800.70747623
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.69728824
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.69495380
78Phagosome_Homo sapiens_hsa041450.68356848
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66544455
80N-Glycan biosynthesis_Homo sapiens_hsa005100.64634114
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61810156
82MicroRNAs in cancer_Homo sapiens_hsa052060.61294830
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.61186936
84Osteoclast differentiation_Homo sapiens_hsa043800.59920454
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59806519
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57090307
87Endocytosis_Homo sapiens_hsa041440.56980803
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55904000
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54119261
90Pertussis_Homo sapiens_hsa051330.53990520
91Protein export_Homo sapiens_hsa030600.53922141
92Viral myocarditis_Homo sapiens_hsa054160.53394609
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.53079295
94Notch signaling pathway_Homo sapiens_hsa043300.52128664
95Staphylococcus aureus infection_Homo sapiens_hsa051500.51610873
96HIF-1 signaling pathway_Homo sapiens_hsa040660.51297419
97Malaria_Homo sapiens_hsa051440.50858912
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50827579
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50654711
100T cell receptor signaling pathway_Homo sapiens_hsa046600.50634260
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.48452709
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47938942
103Caffeine metabolism_Homo sapiens_hsa002320.46384745
104Sphingolipid metabolism_Homo sapiens_hsa006000.45510398
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44725912
106Arachidonic acid metabolism_Homo sapiens_hsa005900.44601260
107Asthma_Homo sapiens_hsa053100.42486535
108TNF signaling pathway_Homo sapiens_hsa046680.42276816
109Basal cell carcinoma_Homo sapiens_hsa052170.41203213
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40809423
111Oocyte meiosis_Homo sapiens_hsa041140.39774130
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.39564893
113Salmonella infection_Homo sapiens_hsa051320.39421408
114mTOR signaling pathway_Homo sapiens_hsa041500.39127691
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37610227
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37509257
117Pancreatic cancer_Homo sapiens_hsa052120.36987589
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.36555143
119Galactose metabolism_Homo sapiens_hsa000520.36376394
120Hepatitis C_Homo sapiens_hsa051600.36298021
121Tuberculosis_Homo sapiens_hsa051520.36254645
122Allograft rejection_Homo sapiens_hsa053300.35650846
123Prostate cancer_Homo sapiens_hsa052150.35601810
124Pathways in cancer_Homo sapiens_hsa052000.34405699
125Linoleic acid metabolism_Homo sapiens_hsa005910.33213895
126Colorectal cancer_Homo sapiens_hsa052100.32719216

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