REEP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.06096131
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.61565676
3synaptic vesicle exocytosis (GO:0016079)4.44488991
4locomotory exploration behavior (GO:0035641)4.42171735
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.30922265
6glutamate secretion (GO:0014047)4.29370690
7regulation of synaptic vesicle exocytosis (GO:2000300)4.09517674
8neuronal action potential propagation (GO:0019227)4.00632029
9proline transport (GO:0015824)3.89907255
10neuron cell-cell adhesion (GO:0007158)3.87668473
11vocalization behavior (GO:0071625)3.71473688
12detection of calcium ion (GO:0005513)3.70074575
13positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.61047254
14exploration behavior (GO:0035640)3.58060658
15regulation of synaptic vesicle transport (GO:1902803)3.55961360
16layer formation in cerebral cortex (GO:0021819)3.55665102
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.52814748
18regulation of synapse structural plasticity (GO:0051823)3.50817948
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.46367989
20protein localization to synapse (GO:0035418)3.44036250
21cellular potassium ion homeostasis (GO:0030007)3.38516834
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.38208774
23positive regulation of actin filament depolymerization (GO:0030836)3.35897841
24neurotransmitter secretion (GO:0007269)3.35722378
25potassium ion homeostasis (GO:0055075)3.34759635
26detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.30174519
27detection of temperature stimulus involved in sensory perception (GO:0050961)3.30174519
28neurofilament cytoskeleton organization (GO:0060052)3.27268187
29sodium ion export (GO:0071436)3.23162499
30activation of protein kinase A activity (GO:0034199)3.22611506
31regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21382641
32detection of temperature stimulus (GO:0016048)3.18874473
33regulation of glutamate receptor signaling pathway (GO:1900449)3.15055710
34negative regulation of microtubule polymerization (GO:0031115)3.12343706
35neurotransmitter uptake (GO:0001504)3.11971860
36regulation of neuronal synaptic plasticity (GO:0048168)3.11937631
37glycine transport (GO:0015816)3.11750583
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.09441220
39positive regulation of potassium ion transmembrane transport (GO:1901381)3.07754972
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04853101
41axon cargo transport (GO:0008088)3.04541127
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04044558
43gamma-aminobutyric acid transport (GO:0015812)3.02418018
44neuron recognition (GO:0008038)3.01679340
45transferrin transport (GO:0033572)3.00017462
46negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.98901230
47dendrite morphogenesis (GO:0048813)2.98260546
48membrane depolarization during action potential (GO:0086010)2.97091520
49synaptic vesicle docking involved in exocytosis (GO:0016081)2.97048097
50regulation of long-term neuronal synaptic plasticity (GO:0048169)2.96980902
51positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96878001
52transmission of nerve impulse (GO:0019226)2.96683822
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.96438616
54ATP hydrolysis coupled proton transport (GO:0015991)2.96438616
55vesicle transport along microtubule (GO:0047496)2.96139603
56Golgi transport vesicle coating (GO:0048200)2.95483918
57COPI coating of Golgi vesicle (GO:0048205)2.95483918
58regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.95090274
59cellular sodium ion homeostasis (GO:0006883)2.94417087
60organelle transport along microtubule (GO:0072384)2.92448216
61trivalent inorganic cation transport (GO:0072512)2.92322078
62ferric iron transport (GO:0015682)2.92322078
63neuronal ion channel clustering (GO:0045161)2.91881379
64L-amino acid import (GO:0043092)2.90529937
65amino acid import (GO:0043090)2.90500328
66establishment of mitochondrion localization (GO:0051654)2.90460882
67cell migration in hindbrain (GO:0021535)2.90341640
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.86418573
69cell communication by electrical coupling (GO:0010644)2.86226496
70neurotransmitter transport (GO:0006836)2.84734591
71neuronal action potential (GO:0019228)2.84642383
72positive regulation of neurotransmitter secretion (GO:0001956)2.83516774
73synaptic transmission, glutamatergic (GO:0035249)2.83266971
74neuromuscular process controlling posture (GO:0050884)2.81138363
75positive regulation of potassium ion transport (GO:0043268)2.80630237
76dendritic spine morphogenesis (GO:0060997)2.77708045
77regulation of vesicle fusion (GO:0031338)2.77676120
78negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77575994
79neuromuscular process controlling balance (GO:0050885)2.77304192
80glutamate receptor signaling pathway (GO:0007215)2.75788427
81axonal fasciculation (GO:0007413)2.75108124
82neuron-neuron synaptic transmission (GO:0007270)2.74926274
83mating behavior (GO:0007617)2.74688168
84calcium-mediated signaling using intracellular calcium source (GO:0035584)2.74648620
85positive regulation of vesicle fusion (GO:0031340)2.72850809
86cell communication involved in cardiac conduction (GO:0086065)2.71206812
87regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.70913825
88negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.69599038
89positive regulation of neurotransmitter transport (GO:0051590)2.68536615
90membrane repolarization (GO:0086009)2.66364002
91response to gravity (GO:0009629)2.66065963
92membrane budding (GO:0006900)2.65789768
93axon ensheathment in central nervous system (GO:0032291)2.65692575
94central nervous system myelination (GO:0022010)2.65692575
95regulation of neurotransmitter secretion (GO:0046928)2.64867077
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.64733627
97adult walking behavior (GO:0007628)2.63621094
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63476691
99response to auditory stimulus (GO:0010996)2.62830171
100potassium ion import (GO:0010107)2.62800197
101regulation of excitatory postsynaptic membrane potential (GO:0060079)2.62381000
102regulation of voltage-gated calcium channel activity (GO:1901385)2.60480102
103regulation of neurotransmitter levels (GO:0001505)2.60354873
104regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59595710
105membrane depolarization (GO:0051899)2.56344979
106regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.56313488
107regulation of cell communication by electrical coupling (GO:0010649)2.56282208
108nerve growth factor signaling pathway (GO:0038180)2.56136729
109acidic amino acid transport (GO:0015800)2.55119946
110long-term memory (GO:0007616)2.55011614
111regulation of clathrin-mediated endocytosis (GO:2000369)2.53546952
112regulation of synaptic plasticity (GO:0048167)2.53398381
113regulation of amyloid precursor protein catabolic process (GO:1902991)2.53355239
114negative regulation of axonogenesis (GO:0050771)2.53182221
115presynaptic membrane assembly (GO:0097105)2.52702957
116regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.52209315
117regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.52138361
118mitochondrion transport along microtubule (GO:0047497)2.51518130
119establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.51518130
120synapse assembly (GO:0007416)2.50490451
121regulation of postsynaptic membrane potential (GO:0060078)2.50473991
122regulation of synaptic transmission, glutamatergic (GO:0051966)2.50238031
123negative regulation of dendrite morphogenesis (GO:0050774)2.49933496
124positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.49889067
125positive regulation of membrane potential (GO:0045838)2.49684206
126vesicle docking involved in exocytosis (GO:0006904)2.49560991
127tricarboxylic acid cycle (GO:0006099)2.47731015
128protein maturation by protein folding (GO:0022417)2.45685587
129vesicle docking (GO:0048278)2.44074095
130peptidyl-cysteine modification (GO:0018198)2.41881308
131regulation of integrin-mediated signaling pathway (GO:2001044)2.38992577
132regulation of neurotransmitter transport (GO:0051588)2.38655124
133regulation of cardiac muscle cell contraction (GO:0086004)2.37624136
134negative regulation of cation channel activity (GO:2001258)2.36178128
135cellular copper ion homeostasis (GO:0006878)2.34538354
136substantia nigra development (GO:0021762)2.33561722
137fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.33327258
138signal release (GO:0023061)2.33044317
139NADH metabolic process (GO:0006734)2.32652485
140myelin maintenance (GO:0043217)2.31464550
141retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.30564347
142long-term synaptic potentiation (GO:0060291)2.28826256
143regulation of dendritic spine development (GO:0060998)2.28398512
144negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.28367430
145negative regulation of calcium ion transmembrane transport (GO:1903170)2.28367430
146positive regulation of cellular amine metabolic process (GO:0033240)2.27517317
147L-glutamate transport (GO:0015813)2.26009855
148establishment of synaptic vesicle localization (GO:0097480)2.24121938
149synaptic vesicle transport (GO:0048489)2.24121938
150cerebellar Purkinje cell layer development (GO:0021680)2.21929575
151cardiac conduction (GO:0061337)2.20593811
152positive regulation of exocytosis (GO:0045921)2.19943154
153response to dietary excess (GO:0002021)2.19230736
154regulation of sodium ion transmembrane transporter activity (GO:2000649)2.19174108
155dicarboxylic acid biosynthetic process (GO:0043650)2.18359123

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.55050823
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13593379
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11384423
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88623817
5GBX2_23144817_ChIP-Seq_PC3_Human2.84184466
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73014801
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73014801
8MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64793685
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63086413
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.63051947
11* ESR1_20079471_ChIP-ChIP_T-47D_Human2.62403520
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56939867
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55576228
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48932482
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.35592231
16REST_21632747_ChIP-Seq_MESCs_Mouse2.28493398
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.25675858
18DROSHA_22980978_ChIP-Seq_HELA_Human2.24579626
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.24116423
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.18746864
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.17740330
22AR_21572438_ChIP-Seq_LNCaP_Human2.11117177
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.10654735
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.06189215
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.03645592
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99733132
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.97026318
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.91803499
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77289175
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76664238
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71722699
32TAF15_26573619_Chip-Seq_HEK293_Human1.60182610
33SOX2_20726797_ChIP-Seq_SW620_Human1.60132218
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57180734
35NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56566103
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.55011283
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.52187594
38SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49784287
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48409678
40HTT_18923047_ChIP-ChIP_STHdh_Human1.47869939
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44640331
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39655992
43ZNF274_21170338_ChIP-Seq_K562_Hela1.39030068
44SMAD4_21799915_ChIP-Seq_A2780_Human1.38161275
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37290674
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36849439
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35946955
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35136891
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33322446
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31841307
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28777015
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28255133
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27242349
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26539432
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.24492544
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23917764
57* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23293052
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22960927
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.20766975
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20318816
61SOX2_21211035_ChIP-Seq_LN229_Gbm1.20006086
62WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18868361
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17686500
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15665849
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12506824
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12419402
67P300_19829295_ChIP-Seq_ESCs_Human1.12376140
68WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11393370
69FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10356456
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.10263462
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.09293466
72KDM2B_26808549_Chip-Seq_K562_Human1.09288389
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.09021213
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08901884
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08637922
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07980573
77AR_25329375_ChIP-Seq_VCAP_Human1.07786868
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.05406087
79AHR_22903824_ChIP-Seq_MCF-7_Human1.05005844
80* CJUN_26792858_Chip-Seq_BT549_Human1.04625836
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04547693
82* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04422473
83AR_19668381_ChIP-Seq_PC3_Human1.03193358
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.02852570
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01634352
86ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01258078
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.01094914
88ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99945563
89SOX2_18555785_Chip-Seq_ESCs_Mouse0.99364847
90* STAT3_23295773_ChIP-Seq_U87_Human0.99293681
91CLOCK_20551151_ChIP-Seq_293T_Human0.98821323
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98801161
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98125600
94RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98110817
95P53_22387025_ChIP-Seq_ESCs_Mouse0.97961274
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97358968
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97100330
98TET1_21490601_ChIP-Seq_MESCs_Mouse0.96877010
99RXR_22158963_ChIP-Seq_LIVER_Mouse0.95912256
100P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95549066
101ARNT_22903824_ChIP-Seq_MCF-7_Human0.95100610
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.94874591
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94488110
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.94169720
105CTCF_27219007_Chip-Seq_Bcells_Human0.94163453
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94001776
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.92727485
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.92702221
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92678493
110GATA2_21666600_ChIP-Seq_HMVEC_Human0.92441235
111CBP_21632823_ChIP-Seq_H3396_Human0.92214705
112EOMES_21245162_ChIP-Seq_HESCs_Human0.91822395
113ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91501543
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91246658
115* RING1B_27294783_Chip-Seq_NPCs_Mouse0.91185342
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89270858
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.89269644
118PU1_27457419_Chip-Seq_LIVER_Mouse0.89038575
119* GATA3_24758297_ChIP-Seq_MCF-7_Human0.88539452
120SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87773433
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87381241
122MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87205844
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86503918
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86492566
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86290375
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86290375
127TP53_18474530_ChIP-ChIP_U2OS_Human0.86241443
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.85944663
129CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85606063
130RXR_22108803_ChIP-Seq_LS180_Human0.84988997
131E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.84965080
132EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84708594
133SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84246763
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83961395
135SUZ12_18555785_Chip-Seq_ESCs_Mouse0.83875560
136CDX2_20551321_ChIP-Seq_CACO-2_Human0.83685349
137GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83012983
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.81403665
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80716197
140TP53_20018659_ChIP-ChIP_R1E_Mouse0.80550820
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80182587
142TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79722169
143ELF5_23300383_ChIP-Seq_T47D_Human0.78652318
144MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.78388933
145LXR_22158963_ChIP-Seq_LIVER_Mouse0.78011832

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.97430515
2MP0004270_analgesia3.90061247
3MP0003880_abnormal_central_pattern3.88153800
4MP0001968_abnormal_touch/_nociception3.75637583
5MP0002735_abnormal_chemical_nociception3.46653714
6MP0003635_abnormal_synaptic_transmissio3.29014080
7MP0002736_abnormal_nociception_after3.20067066
8MP0002734_abnormal_mechanical_nocicepti3.01848417
9MP0002733_abnormal_thermal_nociception2.81548407
10MP0004858_abnormal_nervous_system2.78097758
11MP0009745_abnormal_behavioral_response2.69867201
12MP0002064_seizures2.68165192
13MP0009046_muscle_twitch2.53962882
14MP0001970_abnormal_pain_threshold2.53146884
15MP0002063_abnormal_learning/memory/cond2.52147976
16MP0010234_abnormal_vibrissa_follicle2.51707065
17MP0002272_abnormal_nervous_system2.51110619
18MP0003329_amyloid_beta_deposits2.48988699
19MP0006276_abnormal_autonomic_nervous2.36037547
20MP0005423_abnormal_somatic_nervous2.19561483
21MP0002572_abnormal_emotion/affect_behav2.17117412
22MP0001486_abnormal_startle_reflex2.01563914
23MP0001440_abnormal_grooming_behavior1.97619125
24MP0002876_abnormal_thyroid_physiology1.92846418
25MP0000920_abnormal_myelination1.90913245
26MP0002067_abnormal_sensory_capabilities1.90197033
27MP0001501_abnormal_sleep_pattern1.81172436
28MP0000751_myopathy1.75220228
29MP0009780_abnormal_chondrocyte_physiolo1.73574625
30MP0002184_abnormal_innervation1.72831626
31MP0000778_abnormal_nervous_system1.72509185
32MP0003191_abnormal_cellular_cholesterol1.71062524
33MP0008569_lethality_at_weaning1.69459076
34MP0002909_abnormal_adrenal_gland1.68930661
35MP0005386_behavior/neurological_phenoty1.64946104
36MP0004924_abnormal_behavior1.64946104
37MP0002837_dystrophic_cardiac_calcinosis1.63552593
38MP0004811_abnormal_neuron_physiology1.62492445
39MP0000955_abnormal_spinal_cord1.58804926
40MP0002822_catalepsy1.55755603
41MP0001905_abnormal_dopamine_level1.46393169
42MP0003011_delayed_dark_adaptation1.44053022
43MP0003634_abnormal_glial_cell1.41262785
44MP0003690_abnormal_glial_cell1.40378217
45MP0001529_abnormal_vocalization1.37808390
46MP0003633_abnormal_nervous_system1.37397810
47MP0002882_abnormal_neuron_morphology1.37133623
48MP0005165_increased_susceptibility_to1.34937277
49MP0002066_abnormal_motor_capabilities/c1.34732959
50MP0004885_abnormal_endolymph1.34702654
51MP0004043_abnormal_pH_regulation1.32722822
52MP0002254_reproductive_system_inflammat1.30245993
53MP0002557_abnormal_social/conspecific_i1.29574944
54MP0000604_amyloidosis1.28900276
55MP0004142_abnormal_muscle_tone1.28662187
56MP0004147_increased_porphyrin_level1.28033724
57MP0005248_abnormal_Harderian_gland1.27523175
58MP0006036_abnormal_mitochondrial_physio1.23477515
59MP0001756_abnormal_urination1.21374364
60MP0000013_abnormal_adipose_tissue1.20363846
61MP0001346_abnormal_lacrimal_gland1.18015581
62MP0005058_abnormal_lysosome_morphology1.15943510
63MP0004145_abnormal_muscle_electrophysio1.15833845
64MP0003631_nervous_system_phenotype1.15668333
65MP0001765_abnormal_ion_homeostasis1.15475054
66MP0005379_endocrine/exocrine_gland_phen1.14211551
67MP0000747_muscle_weakness1.14169423
68MP0002229_neurodegeneration1.14148627
69MP0004130_abnormal_muscle_cell1.11996635
70MP0001299_abnormal_eye_distance/1.10149568
71MP0001348_abnormal_lacrimal_gland1.08366981
72MP0003195_calcinosis1.07613011
73MP0005332_abnormal_amino_acid1.05772117
74MP0001986_abnormal_taste_sensitivity1.04150225
75MP0004742_abnormal_vestibular_system1.03220708
76MP0005623_abnormal_meninges_morphology1.02443163
77MP0005645_abnormal_hypothalamus_physiol1.02013825
78MP0003879_abnormal_hair_cell0.99738558
79MP0000427_abnormal_hair_cycle0.99622669
80MP0005365_abnormal_bile_salt0.99464443
81MP0005636_abnormal_mineral_homeostasis0.99288404
82MP0005535_abnormal_body_temperature0.98445852
83MP0002295_abnormal_pulmonary_circulatio0.98099301
84MP0004215_abnormal_myocardial_fiber0.94059049
85MP0003122_maternal_imprinting0.91981098
86MP0005166_decreased_susceptibility_to0.91836456
87MP0003172_abnormal_lysosome_physiology0.91100869
88MP0000749_muscle_degeneration0.90978675
89MP0010386_abnormal_urinary_bladder0.89836149
90MP0004036_abnormal_muscle_relaxation0.88969379
91MP0004085_abnormal_heartbeat0.88871133
92MP0001984_abnormal_olfaction0.88287062
93MP0003632_abnormal_nervous_system0.86934272
94MP0010678_abnormal_skin_adnexa0.86719493
95MP0010329_abnormal_lipoprotein_level0.86682270
96MP0002332_abnormal_exercise_endurance0.86261882
97MP0001502_abnormal_circadian_rhythm0.85694283
98MP0008875_abnormal_xenobiotic_pharmacok0.84498297
99MP0002090_abnormal_vision0.83648481
100MP0003137_abnormal_impulse_conducting0.83033200
101MP0008874_decreased_physiological_sensi0.81330936
102MP0002152_abnormal_brain_morphology0.79726262
103MP0005584_abnormal_enzyme/coenzyme_acti0.79410482
104MP0005551_abnormal_eye_electrophysiolog0.77662153
105MP0004484_altered_response_of0.77010911
106MP0005646_abnormal_pituitary_gland0.75984696
107MP0002972_abnormal_cardiac_muscle0.75858971
108MP0002752_abnormal_somatic_nervous0.75465570
109MP0004233_abnormal_muscle_weight0.75283316
110MP0001664_abnormal_digestion0.74691998
111MP0004019_abnormal_vitamin_homeostasis0.73920903
112MP0000681_abnormal_thyroid_gland0.73541703
113MP0002069_abnormal_eating/drinking_beha0.73484071
114MP0003646_muscle_fatigue0.73314347
115MP0004510_myositis0.72155040
116MP0006082_CNS_inflammation0.70334065
117MP0005253_abnormal_eye_physiology0.70187598
118MP0005620_abnormal_muscle_contractility0.69844769
119MP0005167_abnormal_blood-brain_barrier0.69831734
120MP0003806_abnormal_nucleotide_metabolis0.68611205
121MP0003075_altered_response_to0.68471499
122MP0001963_abnormal_hearing_physiology0.67031953
123MP0004084_abnormal_cardiac_muscle0.65203042
124MP0001177_atelectasis0.64717426
125MP0008872_abnormal_physiological_respon0.61385859
126MP0002751_abnormal_autonomic_nervous0.59445672
127MP0000759_abnormal_skeletal_muscle0.58055291
128MP0005171_absent_coat_pigmentation0.57424658
129MP0003183_abnormal_peptide_metabolism0.56252826
130MP0004087_abnormal_muscle_fiber0.55459833
131MP0001485_abnormal_pinna_reflex0.54351161
132MP0008775_abnormal_heart_ventricle0.53404764
133MP0005083_abnormal_biliary_tract0.53148188
134MP0003045_fibrosis0.51537507

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.98883358
2Focal motor seizures (HP:0011153)4.84119505
3Supranuclear gaze palsy (HP:0000605)4.47419060
4Focal seizures (HP:0007359)4.31876502
5Pheochromocytoma (HP:0002666)4.16252124
6Visual hallucinations (HP:0002367)4.11685016
7Action tremor (HP:0002345)4.08308397
8Atonic seizures (HP:0010819)3.82970797
9Termporal pattern (HP:0011008)3.77926866
10Insidious onset (HP:0003587)3.77926866
11Ankle clonus (HP:0011448)3.77199157
12Neuroendocrine neoplasm (HP:0100634)3.74484895
13Neurofibrillary tangles (HP:0002185)3.68254224
14Ulnar claw (HP:0001178)3.32942019
15Cerebral inclusion bodies (HP:0100314)3.16963873
16Epileptic encephalopathy (HP:0200134)3.13216968
17Absence seizures (HP:0002121)3.11138832
18Abnormality of the corticospinal tract (HP:0002492)3.06945752
19Progressive cerebellar ataxia (HP:0002073)3.04308359
20Limb dystonia (HP:0002451)3.01588006
21Generalized tonic-clonic seizures (HP:0002069)2.94010255
22Mutism (HP:0002300)2.92962373
23Dialeptic seizures (HP:0011146)2.89421846
24Hypokinesia (HP:0002375)2.89005075
25Spastic gait (HP:0002064)2.85775872
26Diminished movement (HP:0002374)2.84000135
27Papilledema (HP:0001085)2.83632971
28Abnormal eating behavior (HP:0100738)2.83488216
29Akinesia (HP:0002304)2.80851065
30Urinary urgency (HP:0000012)2.72638648
31Progressive inability to walk (HP:0002505)2.68276360
32Abnormality of liposaccharide metabolism (HP:0010968)2.67418084
33Abnormality of glycosphingolipid metabolism (HP:0004343)2.67418084
34Abnormality of glycolipid metabolism (HP:0010969)2.67418084
35Increased circulating renin level (HP:0000848)2.67323482
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.64152946
37Dysmetria (HP:0001310)2.62532694
38Febrile seizures (HP:0002373)2.61386812
39Tetraplegia (HP:0002445)2.61245309
40Degeneration of the lateral corticospinal tracts (HP:0002314)2.61009416
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61009416
42Depression (HP:0000716)2.59900763
43Onion bulb formation (HP:0003383)2.59222766
44Peripheral hypomyelination (HP:0007182)2.56705980
45Anxiety (HP:0000739)2.54705888
46Truncal ataxia (HP:0002078)2.52195593
47Urinary bladder sphincter dysfunction (HP:0002839)2.47562745
48Hammertoe (HP:0001765)2.45273215
49Neoplasm of the peripheral nervous system (HP:0100007)2.45022372
50Lower limb muscle weakness (HP:0007340)2.42905964
51Ventricular fibrillation (HP:0001663)2.40246765
52Apathy (HP:0000741)2.39043042
53Myotonia (HP:0002486)2.36958209
54Delusions (HP:0000746)2.36732177
55Foot dorsiflexor weakness (HP:0009027)2.35063788
56Rapidly progressive (HP:0003678)2.34373469
57Torticollis (HP:0000473)2.33600789
58Fetal akinesia sequence (HP:0001989)2.31840644
59Megalencephaly (HP:0001355)2.30351244
60Postural instability (HP:0002172)2.30027032
61Hypoglycemic coma (HP:0001325)2.29957576
62Polyphagia (HP:0002591)2.29895319
63Intention tremor (HP:0002080)2.29171697
64Segmental peripheral demyelination/remyelination (HP:0003481)2.26725085
65Ketoacidosis (HP:0001993)2.25333732
66Hypercortisolism (HP:0001578)2.23541224
67Diminished motivation (HP:0000745)2.23111307
68Steppage gait (HP:0003376)2.22728806
69Hemiparesis (HP:0001269)2.21304211
70Retinal dysplasia (HP:0007973)2.21104819
71Cerebral hypomyelination (HP:0006808)2.19969124
72Syncope (HP:0001279)2.19370525
73Scanning speech (HP:0002168)2.15621514
74Poor eye contact (HP:0000817)2.15020746
75Failure to thrive in infancy (HP:0001531)2.14780388
76Impaired vibration sensation in the lower limbs (HP:0002166)2.14674773
77Cerebral hemorrhage (HP:0001342)2.14345596
78Hyporeflexia of lower limbs (HP:0002600)2.12163922
79Abnormality of the foot musculature (HP:0001436)2.11289827
80Broad-based gait (HP:0002136)2.11060458
81Axonal loss (HP:0003447)2.07620511
82Abnormality of pain sensation (HP:0010832)2.07029239
83Impaired pain sensation (HP:0007328)2.07029239
84Sensorimotor neuropathy (HP:0007141)2.06247343
85Hypoventilation (HP:0002791)2.05371713
86Progressive macrocephaly (HP:0004481)2.05271811
87Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05236561
88Hypoplasia of the brainstem (HP:0002365)2.05236561
89Abnormal social behavior (HP:0012433)2.04740266
90Impaired social interactions (HP:0000735)2.04740266
91Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02686323
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02686323
93Hyperinsulinemic hypoglycemia (HP:0000825)2.02289449
94Epileptiform EEG discharges (HP:0011182)2.01522467
95Exercise-induced muscle cramps (HP:0003710)2.01148334
96Neuronal loss in central nervous system (HP:0002529)2.00204053
97Sudden death (HP:0001699)2.00049990
98Amblyopia (HP:0000646)1.99968119
99Distal sensory impairment (HP:0002936)1.99426120
100Dysdiadochokinesis (HP:0002075)1.99226240
101Hypoglycemic seizures (HP:0002173)1.99187295
102Abnormal atrioventricular conduction (HP:0005150)1.99109859
103Heart block (HP:0012722)1.98864113
104Focal dystonia (HP:0004373)1.98496915
105Diplopia (HP:0000651)1.97416985
106Abnormality of binocular vision (HP:0011514)1.97416985
107Postural tremor (HP:0002174)1.96546117
108Resting tremor (HP:0002322)1.95494090
109Craniofacial dystonia (HP:0012179)1.95313035
110Insulin-resistant diabetes mellitus (HP:0000831)1.94642670
111Acute necrotizing encephalopathy (HP:0006965)1.93960363
112Abnormality of glycolysis (HP:0004366)1.93663115
113Sensory axonal neuropathy (HP:0003390)1.93532578
114Tongue fasciculations (HP:0001308)1.93179305
115Prolonged QT interval (HP:0001657)1.92230349
116Agitation (HP:0000713)1.90795056
117Growth hormone excess (HP:0000845)1.90549636
118Vascular calcification (HP:0004934)1.89777081
119Clonus (HP:0002169)1.88767049
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87637376
121Metaphyseal dysplasia (HP:0100255)1.87305613
122Mitral stenosis (HP:0001718)1.87168046
123EEG with generalized epileptiform discharges (HP:0011198)1.87029589
124Rigidity (HP:0002063)1.86870947
125Conjunctival hamartoma (HP:0100780)1.86812441
126Progressive neurologic deterioration (HP:0002344)1.86231386
127Ventricular arrhythmia (HP:0004308)1.85494496
128Hemiplegia (HP:0002301)1.85381498
129Abnormality of the vocal cords (HP:0008777)1.85361146
130Abnormal mitochondria in muscle tissue (HP:0008316)1.84628206
131Nuclear cataract (HP:0100018)1.84396808
132Exercise-induced myalgia (HP:0003738)1.84132186
133Bundle branch block (HP:0011710)1.83664663
134Goiter (HP:0000853)1.83564786
135Gaze-evoked nystagmus (HP:0000640)1.82244871
136Psychosis (HP:0000709)1.81497277
137Slow progression (HP:0003677)1.80922944
138Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.80753335
139Glucose intolerance (HP:0000833)1.80592933
140Tetraparesis (HP:0002273)1.80410535
141Inability to walk (HP:0002540)1.80256537
142Type II lissencephaly (HP:0007260)1.79733165
143Increased variability in muscle fiber diameter (HP:0003557)1.79573198
144Autoamputation (HP:0001218)1.79023498
145Distal lower limb muscle weakness (HP:0009053)1.78022617
146Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.77103543
147Testicular atrophy (HP:0000029)1.77000571
148Difficulty running (HP:0009046)1.76728813
149Bradykinesia (HP:0002067)1.76176359
150Hypokalemic alkalosis (HP:0001949)1.76166749
151Steatorrhea (HP:0002570)1.75566213
152Mucopolysacchariduria (HP:0008155)1.74146828
153Urinary glycosaminoglycan excretion (HP:0003541)1.74146828
154Increased serum pyruvate (HP:0003542)1.73890576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.62777656
2NTRK33.42501055
3MARK13.15242263
4NTRK12.96273503
5MINK12.86042641
6KSR22.53384484
7LMTK22.26412042
8PHKG12.22725772
9PHKG22.22725772
10PAK62.20750270
11MAP3K42.14613781
12STK392.05247223
13EPHA42.03046026
14LIMK11.97384922
15MST41.93658674
16MAP2K71.76644363
17MAP3K121.74838289
18MYLK1.72789825
19MAP3K21.68501907
20ARAF1.60598833
21DAPK21.59497883
22NTRK21.58542389
23GRK51.54495484
24PDK21.50194504
25TNIK1.50084555
26BMPR21.49138301
27CAMKK11.46989392
28TRIM281.46476383
29ERBB31.46242961
30CDK51.46027815
31PRKD31.45629391
32MAP2K41.44890228
33NEK61.44780273
34LATS21.44011831
35UHMK11.41549844
36RIPK41.40084325
37MAPK131.39236913
38EIF2AK11.37888535
39RET1.37686319
40MAPKAPK31.36759110
41OXSR11.31480207
42CAMKK21.29319221
43CASK1.23573759
44WNK41.21568851
45SIK31.20517241
46NEK11.15296294
47EPHA21.14350474
48CDK191.14117817
49TESK21.12484749
50CDK141.07763473
51RIPK11.07075342
52WNK11.06580680
53PAK31.04774565
54CSNK1G21.01736663
55PLK20.96811778
56CAMK2A0.96293301
57MST1R0.95883076
58PRPF4B0.92515029
59CDK180.90244725
60CDK150.90156064
61PRKCG0.89986312
62KSR10.88845387
63TYRO30.87497109
64FES0.86364263
65PKN10.86042016
66ROCK20.85193751
67SCYL20.83681384
68PRKCH0.82736308
69SGK2230.81870500
70SGK4940.81870500
71PIK3CA0.79454623
72EPHB10.79447250
73MAP3K10.79050748
74MAP2K10.78510747
75PDPK10.77621637
76CDK11A0.77128174
77PAK40.75599001
78CAMK2D0.75206268
79CAMK2B0.73809028
80PRKCE0.71612286
81BCR0.71464875
82MAPKAPK50.71248050
83CSNK1G30.70847730
84DMPK0.69422001
85PIM20.68239679
86PNCK0.67620087
87FER0.67056152
88EIF2AK30.67029345
89JAK10.66769201
90PTK20.66008387
91PDK10.65712078
92TAOK10.64760133
93WNK30.63080010
94PTK2B0.61341895
95CAMK2G0.61100083
96PINK10.58572075
97ROCK10.58124134
98STK380.57471073
99FYN0.55107027
100ABL20.54702183
101STK110.53815136
102CSNK1G10.52873256
103RPS6KA20.52528232
104DYRK20.52210572
105TRIB30.51934009
106CAMK10.51425772
107MARK20.51425056
108PRKCZ0.49793759
109FGR0.49639702
110MAPK120.48491871
111TSSK60.48349042
112CAMK1G0.48249356
113GRK70.48045562
114MAP3K130.47482818
115DAPK10.47404409
116ILK0.46454917
117RAF10.46310008
118DAPK30.46242600
119TESK10.46072357
120FRK0.45523484
121TRPM70.44509834
122PRKG20.43653923
123PRKD10.43383433
124ALK0.42113714
125STK38L0.41905157
126BRSK10.41646804
127FGFR20.41597874
128CSNK1A1L0.41507415
129MAP2K60.40457713
130PRKCA0.39178317
131ADRBK10.38747817
132MUSK0.38603486
133MATK0.38150078
134SIK20.38100058
135CCNB10.36917973
136MET0.36620313
137PRKCI0.36423955
138OBSCN0.36373130
139CSNK1A10.35309160

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.07952999
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.38202743
3Nicotine addiction_Homo sapiens_hsa050332.32160354
4GABAergic synapse_Homo sapiens_hsa047272.08405050
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06975190
6Vitamin B6 metabolism_Homo sapiens_hsa007502.00835375
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.00439765
8Circadian entrainment_Homo sapiens_hsa047131.99950365
9Glutamatergic synapse_Homo sapiens_hsa047241.94343340
10Olfactory transduction_Homo sapiens_hsa047401.92868253
11Long-term potentiation_Homo sapiens_hsa047201.90142291
12Dopaminergic synapse_Homo sapiens_hsa047281.86129524
13Morphine addiction_Homo sapiens_hsa050321.81759462
14Salivary secretion_Homo sapiens_hsa049701.73875645
15Cholinergic synapse_Homo sapiens_hsa047251.73323972
16Collecting duct acid secretion_Homo sapiens_hsa049661.66801366
17Amphetamine addiction_Homo sapiens_hsa050311.66246228
18Insulin secretion_Homo sapiens_hsa049111.65045030
19Gastric acid secretion_Homo sapiens_hsa049711.64420575
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59102095
21Serotonergic synapse_Homo sapiens_hsa047261.54524626
22beta-Alanine metabolism_Homo sapiens_hsa004101.49574150
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.48592678
24Cardiac muscle contraction_Homo sapiens_hsa042601.44079215
25Long-term depression_Homo sapiens_hsa047301.42298608
26Vibrio cholerae infection_Homo sapiens_hsa051101.41348770
27Renin secretion_Homo sapiens_hsa049241.39455982
28Pancreatic secretion_Homo sapiens_hsa049721.38700377
29Cocaine addiction_Homo sapiens_hsa050301.38084210
30Taste transduction_Homo sapiens_hsa047421.35699898
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35096116
32Protein export_Homo sapiens_hsa030601.35050314
33Axon guidance_Homo sapiens_hsa043601.34866715
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34133761
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32360532
36Sulfur metabolism_Homo sapiens_hsa009201.31955427
37Proteasome_Homo sapiens_hsa030501.30103135
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28840051
39Oxytocin signaling pathway_Homo sapiens_hsa049211.28830724
40Gap junction_Homo sapiens_hsa045401.25717902
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24790773
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.24183262
43Histidine metabolism_Homo sapiens_hsa003401.23790695
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23358079
45Oxidative phosphorylation_Homo sapiens_hsa001901.23122173
46GnRH signaling pathway_Homo sapiens_hsa049121.21681243
47Phenylalanine metabolism_Homo sapiens_hsa003601.21486883
48Calcium signaling pathway_Homo sapiens_hsa040201.18001271
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16421850
50Mineral absorption_Homo sapiens_hsa049781.14446068
51Arginine and proline metabolism_Homo sapiens_hsa003301.13968772
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11902069
53Alzheimers disease_Homo sapiens_hsa050101.11079245
54Parkinsons disease_Homo sapiens_hsa050121.08747918
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08283585
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.07367977
57Circadian rhythm_Homo sapiens_hsa047101.05658374
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03212852
59Estrogen signaling pathway_Homo sapiens_hsa049151.00832050
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99009380
61cAMP signaling pathway_Homo sapiens_hsa040240.97819826
62Bile secretion_Homo sapiens_hsa049760.97536947
63Glioma_Homo sapiens_hsa052140.97129675
64Propanoate metabolism_Homo sapiens_hsa006400.96937195
65Dorso-ventral axis formation_Homo sapiens_hsa043200.96548169
66Arginine biosynthesis_Homo sapiens_hsa002200.96323160
67Type II diabetes mellitus_Homo sapiens_hsa049300.95809857
68Folate biosynthesis_Homo sapiens_hsa007900.95239693
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.93091692
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93024775
71ErbB signaling pathway_Homo sapiens_hsa040120.92842572
72Dilated cardiomyopathy_Homo sapiens_hsa054140.92006370
73Fatty acid metabolism_Homo sapiens_hsa012120.88418415
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.88099286
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.84551244
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83706199
77Sphingolipid metabolism_Homo sapiens_hsa006000.82378800
78Butanoate metabolism_Homo sapiens_hsa006500.82005553
79Melanogenesis_Homo sapiens_hsa049160.81686724
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80895801
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80796084
82Endocytosis_Homo sapiens_hsa041440.80612865
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.79042404
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78558379
85Pyruvate metabolism_Homo sapiens_hsa006200.78247347
86VEGF signaling pathway_Homo sapiens_hsa043700.76379011
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75047464
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73230027
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.72134404
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71705667
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71421003
92Fatty acid degradation_Homo sapiens_hsa000710.70938024
93Thyroid hormone synthesis_Homo sapiens_hsa049180.69529851
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68971424
95Peroxisome_Homo sapiens_hsa041460.67948264
96Renal cell carcinoma_Homo sapiens_hsa052110.67811856
97Phagosome_Homo sapiens_hsa041450.67572560
98Carbon metabolism_Homo sapiens_hsa012000.66755986
99Choline metabolism in cancer_Homo sapiens_hsa052310.65010415
100Tyrosine metabolism_Homo sapiens_hsa003500.64044125
101Ras signaling pathway_Homo sapiens_hsa040140.63568821
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62961874
103Lysosome_Homo sapiens_hsa041420.62882696
104Steroid biosynthesis_Homo sapiens_hsa001000.60680837
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59911038
106PPAR signaling pathway_Homo sapiens_hsa033200.59888393
107MAPK signaling pathway_Homo sapiens_hsa040100.59340922
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58986487
109Rheumatoid arthritis_Homo sapiens_hsa053230.57593791
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57205395
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56956464
112Regulation of autophagy_Homo sapiens_hsa041400.56341121
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56286821
114Glucagon signaling pathway_Homo sapiens_hsa049220.55125415
115Insulin signaling pathway_Homo sapiens_hsa049100.54323427
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53877970
117Glutathione metabolism_Homo sapiens_hsa004800.52758684
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52581651
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51960876
120Prion diseases_Homo sapiens_hsa050200.51830286
121Salmonella infection_Homo sapiens_hsa051320.51330227
122Rap1 signaling pathway_Homo sapiens_hsa040150.51181063
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51160751
124Oocyte meiosis_Homo sapiens_hsa041140.49926996
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48338445
126Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48132463
127Huntingtons disease_Homo sapiens_hsa050160.46657635
128Ether lipid metabolism_Homo sapiens_hsa005650.44576778
129Endometrial cancer_Homo sapiens_hsa052130.43971004
130Tryptophan metabolism_Homo sapiens_hsa003800.43680132
131Fatty acid elongation_Homo sapiens_hsa000620.42640526
132Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41447037
133Protein digestion and absorption_Homo sapiens_hsa049740.40399700
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40332225
135Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40168368
136Tight junction_Homo sapiens_hsa045300.39659184
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38928753
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38597326
139N-Glycan biosynthesis_Homo sapiens_hsa005100.38584353
140Fructose and mannose metabolism_Homo sapiens_hsa000510.38491944
141Fatty acid biosynthesis_Homo sapiens_hsa000610.36294995
142Chemokine signaling pathway_Homo sapiens_hsa040620.36180859
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35819952
144mTOR signaling pathway_Homo sapiens_hsa041500.35445021

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