REG1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)9.80156360
2digestion (GO:0007586)9.38903307
3intestinal cholesterol absorption (GO:0030299)8.68725891
4intestinal absorption (GO:0050892)8.22115102
5negative regulation of epidermal cell differentiation (GO:0045605)7.78928080
6antibacterial humoral response (GO:0019731)6.85350512
7regulation of cellular extravasation (GO:0002691)6.66727725
8antimicrobial humoral response (GO:0019730)6.54429338
9angiotensin maturation (GO:0002003)6.46879793
10transcytosis (GO:0045056)5.94355063
11negative regulation of epidermis development (GO:0045683)5.79144925
12maintenance of gastrointestinal epithelium (GO:0030277)5.60024005
13phosphatidylserine acyl-chain remodeling (GO:0036150)5.59569578
14regulation of guanylate cyclase activity (GO:0031282)5.58496954
15phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.46645153
16phosphatidylinositol acyl-chain remodeling (GO:0036149)5.44715180
17regulation of phospholipase A2 activity (GO:0032429)5.16681799
18glycolipid catabolic process (GO:0019377)4.80169501
19regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.63552492
20regulation of keratinocyte differentiation (GO:0045616)4.52755440
21daunorubicin metabolic process (GO:0044597)4.42979411
22polyketide metabolic process (GO:0030638)4.42979411
23doxorubicin metabolic process (GO:0044598)4.42979411
24regulation of keratinocyte proliferation (GO:0010837)4.42265846
25positive regulation of respiratory burst (GO:0060267)4.40855473
26positive regulation of guanylate cyclase activity (GO:0031284)4.39425055
27positive regulation of pseudopodium assembly (GO:0031274)4.33359270
28innate immune response in mucosa (GO:0002227)4.29813017
29arachidonic acid secretion (GO:0050482)4.25661943
30icosanoid secretion (GO:0032309)4.25661943
31digestive system process (GO:0022600)4.23832917
32calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.14786934
33membrane lipid catabolic process (GO:0046466)4.14233057
34ceramide catabolic process (GO:0046514)4.11610356
35NADH metabolic process (GO:0006734)4.10454508
36epithelial structure maintenance (GO:0010669)4.04090913
37icosanoid transport (GO:0071715)3.91570252
38fatty acid derivative transport (GO:1901571)3.91570252
39acute-phase response (GO:0006953)3.91418025
40aminoglycoside antibiotic metabolic process (GO:0030647)3.91071641
41regulation of pseudopodium assembly (GO:0031272)3.89822442
42phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.89493359
43peptide catabolic process (GO:0043171)3.85155647
44regulation of bile acid biosynthetic process (GO:0070857)3.83876942
45cellular glucuronidation (GO:0052695)3.82051824
46uronic acid metabolic process (GO:0006063)3.81749448
47glucuronate metabolic process (GO:0019585)3.81749448
48phosphatidylserine metabolic process (GO:0006658)3.79914197
49regulation of vitamin metabolic process (GO:0030656)3.77728188
50phosphatidylcholine acyl-chain remodeling (GO:0036151)3.72943702
51mucosal immune response (GO:0002385)3.58626611
52leukotriene biosynthetic process (GO:0019370)3.54995905
53positive regulation of glycoprotein biosynthetic process (GO:0010560)3.54004516
54leukotriene metabolic process (GO:0006691)3.51446555
55cellular response to cadmium ion (GO:0071276)3.46738152
56glycoside metabolic process (GO:0016137)3.46322889
57peptide hormone processing (GO:0016486)3.41712360
58phosphatidic acid biosynthetic process (GO:0006654)3.39121917
59phosphatidic acid metabolic process (GO:0046473)3.39121917
60regulation of triglyceride catabolic process (GO:0010896)3.37079010
61regulation of acrosome reaction (GO:0060046)3.36550311
62alditol phosphate metabolic process (GO:0052646)3.34337874
63regulation of cGMP biosynthetic process (GO:0030826)3.33144461
64sphingolipid catabolic process (GO:0030149)3.29781289
65regulation of systemic arterial blood pressure by hormone (GO:0001990)3.29514914
66regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.29514914
67endocrine process (GO:0050886)3.29514914
68organ or tissue specific immune response (GO:0002251)3.29430160
69fructose metabolic process (GO:0006000)3.28486374
70positive regulation of glycoprotein metabolic process (GO:1903020)3.27227550
71negative regulation of hormone metabolic process (GO:0032351)3.25208350
72tetrapyrrole metabolic process (GO:0033013)3.24745292
73complement activation, classical pathway (GO:0006958)3.20259317
74neutrophil mediated immunity (GO:0002446)3.18532184
75arginine metabolic process (GO:0006525)3.11685651
76hormone catabolic process (GO:0042447)3.11070970
77nucleotide-sugar biosynthetic process (GO:0009226)3.09389761
78cyclooxygenase pathway (GO:0019371)3.08209531
79regulation of systemic arterial blood pressure (GO:0003073)3.07522264
80glomerular filtration (GO:0003094)3.05505707
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.04805383
82arginine catabolic process (GO:0006527)3.03077025
83GDP-mannose metabolic process (GO:0019673)3.02067768
84vitamin A metabolic process (GO:0006776)3.00174371
85diacylglycerol metabolic process (GO:0046339)2.95444813
86primary alcohol catabolic process (GO:0034310)2.93530965
87urea cycle (GO:0000050)2.91959008
88regulation of cholesterol homeostasis (GO:2000188)2.91811402
89epoxygenase P450 pathway (GO:0019373)2.91339785
90antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.90531924
91acute inflammatory response (GO:0002526)2.87734507
92cellular response to zinc ion (GO:0071294)2.84652541
93receptor guanylyl cyclase signaling pathway (GO:0007168)2.83860689
94regulation of epidermal cell differentiation (GO:0045604)2.83803273
95regulation of respiratory burst (GO:0060263)2.82785489
96renal filtration (GO:0097205)2.76214744
97urea metabolic process (GO:0019627)2.74518908
98regulation of necrotic cell death (GO:0010939)2.73463338
99lipoprotein transport (GO:0042953)2.72228306
100antigen processing and presentation of endogenous antigen (GO:0019883)2.71650450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.15733431
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.08913683
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.08904527
4GATA4_25053715_ChIP-Seq_YYC3_Human3.42166583
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.40879403
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.40722138
7SOX2_27498859_Chip-Seq_STOMACH_Mouse3.10787227
8HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.08081758
9GATA6_25053715_ChIP-Seq_YYC3_Human2.82595169
10SOX2_20726797_ChIP-Seq_SW620_Human2.76592578
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.64068632
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.41769193
13FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.27362159
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.23164421
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.15079571
16EGR1_23403033_ChIP-Seq_LIVER_Mouse2.13543884
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.09977149
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09494433
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08277691
20FOXO3_23340844_ChIP-Seq_DLD1_Human2.04902706
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.02661213
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97374528
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87780555
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.87627438
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.85529444
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.81463452
27EGR1_19032775_ChIP-ChIP_M12_Human1.81339761
28PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.70121164
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.68239243
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.62128435
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58912262
32GATA1_22025678_ChIP-Seq_K562_Human1.50310148
33* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.50283687
34* TCF4_18268006_ChIP-ChIP_LS174T_Human1.50063967
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.44030841
36* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.37868542
37BP1_19119308_ChIP-ChIP_Hs578T_Human1.37834009
38* FOXA1_25552417_ChIP-Seq_VCAP_Human1.36024163
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31189562
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29666725
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28101117
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.27847351
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27391333
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.24763235
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22846755
46NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22118555
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.19805907
48FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19501448
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.16217359
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.16217359
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.16217359
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16166393
53KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16088367
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.14820280
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.13629924
56CJUN_26792858_Chip-Seq_BT549_Human1.12697069
57CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.11950736
58CDX2_22108803_ChIP-Seq_LS180_Human1.10654671
59NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05804286
60HNF4A_19822575_ChIP-Seq_HepG2_Human1.05674564
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05631209
62TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04041977
63STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00470281
64* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99327662
65BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.97862916
66EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97189853
67CEBPB_22108803_ChIP-Seq_LS180_Human0.95360519
68SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95188286
69GATA2_19941826_ChIP-Seq_K562_Human0.94880010
70SA1_27219007_Chip-Seq_Bcells_Human0.92192156
71FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91888339
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90364500
73RACK7_27058665_Chip-Seq_MCF-7_Human0.89779068
74BCOR_27268052_Chip-Seq_Bcells_Human0.89370758
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88836809
76PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.87931805
77LXR_22292898_ChIP-Seq_THP-1_Human0.87433541
78HNFA_21074721_ChIP-Seq_CACO-2_Human0.86613342
79TAF2_19829295_ChIP-Seq_ESCs_Human0.84332567
80CLOCK_20551151_ChIP-Seq_293T_Human0.84060810
81ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81612943
82AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80685908
83CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.80490397
84HTT_18923047_ChIP-ChIP_STHdh_Human0.80056846
85* KLF5_25053715_ChIP-Seq_YYC3_Human0.79538618
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78330878
87GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78257280
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76731863
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.76702075
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75571717
91JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.75252697
92STAT1_20625510_ChIP-Seq_HELA_Human0.73694617
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.73685043
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.73514913
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73440926
96P300_27268052_Chip-Seq_Bcells_Human0.73272980
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73135406
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73062434
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.72953919
100NANOG_20526341_ChIP-Seq_ESCs_Human0.72132108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption8.09651637
2MP0005360_urolithiasis5.05919273
3MP0005365_abnormal_bile_salt4.84485461
4MP0003868_abnormal_feces_composition4.74599996
5MP0010234_abnormal_vibrissa_follicle3.59308673
6MP0005085_abnormal_gallbladder_physiolo3.33735840
7MP0002139_abnormal_hepatobiliary_system3.25083902
8MP0001873_stomach_inflammation2.95731891
9MP0002876_abnormal_thyroid_physiology2.74904298
10MP0009840_abnormal_foam_cell2.57084044
11MP0010155_abnormal_intestine_physiology2.55583730
12MP0002138_abnormal_hepatobiliary_system2.31883020
13MP0009379_abnormal_foot_pigmentation2.30017083
14MP0004019_abnormal_vitamin_homeostasis2.20250239
15MP0010352_gastrointestinal_tract_polyps2.19026464
16MP0003183_abnormal_peptide_metabolism2.12206606
17MP0003300_gastrointestinal_ulcer2.07685702
18MP0010386_abnormal_urinary_bladder2.05588424
19MP0004264_abnormal_extraembryonic_tissu2.05487000
20MP0001664_abnormal_digestion1.99014582
21MP0003866_abnormal_defecation1.96538939
22MP0004858_abnormal_nervous_system1.88992034
23MP0004782_abnormal_surfactant_physiolog1.79251898
24MP0010329_abnormal_lipoprotein_level1.74615278
25MP0004147_increased_porphyrin_level1.73939800
26MP0005166_decreased_susceptibility_to1.69975426
27MP0000678_abnormal_parathyroid_gland1.69331413
28MP0005332_abnormal_amino_acid1.52061539
29MP0009643_abnormal_urine_homeostasis1.46651906
30MP0001663_abnormal_digestive_system1.45557148
31MP0000462_abnormal_digestive_system1.42654899
32MP0001756_abnormal_urination1.40081283
33MP0000490_abnormal_crypts_of1.37273759
34MP0005448_abnormal_energy_balance1.36749729
35MP0003252_abnormal_bile_duct1.36193735
36MP0003724_increased_susceptibility_to1.35980024
37MP0002118_abnormal_lipid_homeostasis1.31808745
38MP0003436_decreased_susceptibility_to1.28413683
39MP0003959_abnormal_lean_body1.27551015
40MP0000477_abnormal_intestine_morphology1.24314446
41MP0005381_digestive/alimentary_phenotyp1.23995336
42MP0001845_abnormal_inflammatory_respons1.20792488
43MP0005083_abnormal_biliary_tract1.18214320
44MP0001765_abnormal_ion_homeostasis1.14700176
45MP0009785_altered_susceptibility_to1.13086326
46MP0000538_abnormal_urinary_bladder1.12150060
47MP0003329_amyloid_beta_deposits1.07883333
48MP0005220_abnormal_exocrine_pancreas1.07657164
49MP0008004_abnormal_stomach_pH1.07632356
50MP0001790_abnormal_immune_system1.06023557
51MP0005387_immune_system_phenotype1.06023557
52MP0005409_darkened_coat_color1.05926803
53MP0000465_gastrointestinal_hemorrhage1.04325698
54MP0002136_abnormal_kidney_physiology1.02230521
55MP0005636_abnormal_mineral_homeostasis0.98947282
56MP0002693_abnormal_pancreas_physiology0.98458224
57MP0001764_abnormal_homeostasis0.96055017
58MP0004043_abnormal_pH_regulation0.95794620
59MP0002166_altered_tumor_susceptibility0.92004338
60MP0002796_impaired_skin_barrier0.91136167
61MP0002277_abnormal_respiratory_mucosa0.88564239
62MP0000604_amyloidosis0.88531318
63MP0005025_abnormal_response_to0.87924549
64MP0001533_abnormal_skeleton_physiology0.86059511
65MP0003283_abnormal_digestive_organ0.85820972
66MP0005319_abnormal_enzyme/_coenzyme0.83276286
67MP0001501_abnormal_sleep_pattern0.82705138
68MP0003075_altered_response_to0.82178232
69MP0000681_abnormal_thyroid_gland0.81103082
70MP0008469_abnormal_protein_level0.80520704
71MP0002078_abnormal_glucose_homeostasis0.77418489
72MP0003806_abnormal_nucleotide_metabolis0.73597314
73MP0003953_abnormal_hormone_level0.72423281
74MP0001485_abnormal_pinna_reflex0.71795501
75MP0005334_abnormal_fat_pad0.71119439
76MP0003879_abnormal_hair_cell0.70924358
77MP0000609_abnormal_liver_physiology0.69740532
78MP0002098_abnormal_vibrissa_morphology0.69337329
79MP0003195_calcinosis0.68027661
80MP0006082_CNS_inflammation0.67550040
81MP0004947_skin_inflammation0.67476964
82MP0005584_abnormal_enzyme/coenzyme_acti0.67276745
83MP0002909_abnormal_adrenal_gland0.66976729
84MP0000685_abnormal_immune_system0.65324099
85MP0009764_decreased_sensitivity_to0.64314429
86MP0000537_abnormal_urethra_morphology0.63983408
87MP0003045_fibrosis0.63856508
88MP0001881_abnormal_mammary_gland0.63761090
89MP0002132_abnormal_respiratory_system0.63487966
90MP0009642_abnormal_blood_homeostasis0.63219518
91MP0005452_abnormal_adipose_tissue0.62980853
92MP0008872_abnormal_physiological_respon0.62174522
93MP0001835_abnormal_antigen_presentation0.60146563
94MP0002006_tumorigenesis0.60019840
95MP0002148_abnormal_hypersensitivity_rea0.59580864
96MP0005310_abnormal_salivary_gland0.57539463
97MP0005165_increased_susceptibility_to0.56116917
98MP0005671_abnormal_response_to0.56108840
99MP0009333_abnormal_splenocyte_physiolog0.55903112
100MP0000613_abnormal_salivary_gland0.55247549

Predicted human phenotypes

RankGene SetZ-score
1Exocrine pancreatic insufficiency (HP:0001738)7.80754775
2Abnormality of glutamine family amino acid metabolism (HP:0010902)7.66611983
3Malnutrition (HP:0004395)6.00313450
4Hypoproteinemia (HP:0003075)5.78654092
5Hydroxyprolinuria (HP:0003080)5.39109033
6Abnormality of proline metabolism (HP:0010907)5.39109033
7Systemic lupus erythematosus (HP:0002725)4.77933952
8Ileus (HP:0002595)4.66581223
9Abnormality of the vitamin B12 metabolism (HP:0004341)3.94893214
10* Pancreatitis (HP:0001733)3.88050175
11Abnormality of vitamin B metabolism (HP:0004340)3.82085438
12Chronic diarrhea (HP:0002028)3.55620930
13Glomerulonephritis (HP:0000099)3.54660530
14Congenital sensorineural hearing impairment (HP:0008527)3.25640492
15Abnormality of the pleura (HP:0002103)3.22900497
16Abnormality of vitamin metabolism (HP:0100508)3.18692274
17Villous atrophy (HP:0011473)3.12716738
18Abnormality of small intestinal villus morphology (HP:0011472)3.12716738
19Hypobetalipoproteinemia (HP:0003563)2.98965394
20Complement deficiency (HP:0004431)2.98477022
21Hyperphosphatemia (HP:0002905)2.94370991
22Abnormality of complement system (HP:0005339)2.79800554
23Abnormality of urine glucose concentration (HP:0011016)2.77976237
24Glycosuria (HP:0003076)2.77976237
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.72990803
26Gout (HP:0001997)2.65632801
27Nephritis (HP:0000123)2.59529563
28Hyperammonemia (HP:0001987)2.57255217
29Goiter (HP:0000853)2.55154759
30Rectal prolapse (HP:0002035)2.54851676
31Decreased circulating renin level (HP:0003351)2.50561951
32Hyperuricemia (HP:0002149)2.48135189
33Increased purine levels (HP:0004368)2.48135189
34Right ventricular cardiomyopathy (HP:0011663)2.47542027
35Eczematoid dermatitis (HP:0000976)2.47158271
36Hyperparathyroidism (HP:0000843)2.39493109
37Vascular calcification (HP:0004934)2.35524140
38Proximal tubulopathy (HP:0000114)2.30557704
39Alkalosis (HP:0001948)2.29784297
40Widely patent fontanelles and sutures (HP:0004492)2.28359493
41Acanthocytosis (HP:0001927)2.27807300
42Pigmentary retinal degeneration (HP:0001146)2.27089889
43Nausea (HP:0002018)2.24757444
44Potter facies (HP:0002009)2.23844142
45Facial shape deformation (HP:0011334)2.23844142
46Dicarboxylic aciduria (HP:0003215)2.21071258
47Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21071258
48Abnormal pancreas size (HP:0012094)2.20075195
49Symptomatic seizures (HP:0011145)2.18849500
50Late onset (HP:0003584)2.17839255
51Hypophosphatemia (HP:0002148)2.14396954
52Abnormality of purine metabolism (HP:0004352)2.09318401
53Abdominal distention (HP:0003270)2.09230706
54Hypotension (HP:0002615)2.07173968
55Abnormality of renin-angiotensin system (HP:0000847)2.06552153
56Cardiovascular calcification (HP:0011915)2.05407095
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.05120457
58Ventricular fibrillation (HP:0001663)2.05054013
59Abnormal biliary tract morphology (HP:0012440)2.03086110
60Hyperactive renin-angiotensin system (HP:0000841)2.01917935
61Metabolic alkalosis (HP:0200114)2.01884980
62Tetraparesis (HP:0002273)2.00655110
63Steatorrhea (HP:0002570)11.3964010
64Fat malabsorption (HP:0002630)10.1680059
65Abnormality of glycine metabolism (HP:0010895)1.99190232
66Abnormality of serine family amino acid metabolism (HP:0010894)1.99190232
67Xanthomatosis (HP:0000991)1.98539348
68Nephrolithiasis (HP:0000787)1.97506934
69Abdominal pain (HP:0002027)1.94410600
70Hyperphosphaturia (HP:0003109)1.93098631
71Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.91781546
72Abnormality of nucleobase metabolism (HP:0010932)1.85167143
73Gastrointestinal dysmotility (HP:0002579)1.84474917
74Metabolic acidosis (HP:0001942)1.82536378
75Hypoglycemic coma (HP:0001325)1.81903631
76Renal tubular acidosis (HP:0001947)1.80559729
77Abnormal glucose tolerance (HP:0001952)1.79827831
78Cerebral palsy (HP:0100021)1.77351581
79Hypoglycemic seizures (HP:0002173)1.76020866
80Posterior subcapsular cataract (HP:0007787)1.75746875
81Focal segmental glomerulosclerosis (HP:0000097)1.75362747
82Confusion (HP:0001289)1.74441807
83Vacuolated lymphocytes (HP:0001922)1.73740987
84Dehydration (HP:0001944)1.71765540
85Abnormality of magnesium homeostasis (HP:0004921)1.70531356
86Abnormal urine phosphate concentration (HP:0012599)1.70509851
87Megaloblastic anemia (HP:0001889)1.70124672
88Hemorrhage of the eye (HP:0011885)1.69798048
89Petechiae (HP:0000967)1.69181808
90Rhabdomyolysis (HP:0003201)1.69023488
91Wide cranial sutures (HP:0010537)1.68624673
92Insulin-resistant diabetes mellitus (HP:0000831)1.66392106
93Hyperinsulinemic hypoglycemia (HP:0000825)1.63919220
94Growth hormone excess (HP:0000845)1.61984710
95Glomerulosclerosis (HP:0000096)1.58390096
96Hyperglycinuria (HP:0003108)1.58195972
97Abnormality of chloride homeostasis (HP:0011422)1.57838639
98Methylmalonic aciduria (HP:0012120)1.56539471
99Bone cyst (HP:0012062)1.55945097
100Pili torti (HP:0003777)1.55462820

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.34218028
2ERN14.46076110
3MST1R4.18291309
4ACVR1B3.88422978
5PDK23.35250161
6PRKG23.33373488
7EPHA23.23720728
8STK393.18504723
9EPHA32.88905778
10RIPK12.73834179
11OXSR12.58899002
12FGFR42.44171653
13MAP3K122.33281383
14STK242.17113320
15EPHB11.95578154
16TYK21.73734362
17GRK11.69413367
18TGFBR21.60652431
19MAP3K31.52346318
20NLK1.44074389
21MST41.42552360
22MET1.41640704
23FGFR31.35858845
24MAP3K21.34991886
25FER1.34255163
26MAP3K141.33050193
27MYLK1.29202474
28MAP3K11.25009355
29EPHB21.24019590
30TESK11.17065894
31IRAK11.12966297
32PIK3CA1.12656868
33PTK61.08596882
34JAK10.98384369
35PASK0.95333372
36TBK10.95189288
37EIF2AK30.93568486
38ZAP700.88098882
39CDC42BPA0.86575706
40PDPK10.79904083
41DDR20.79878717
42MAP3K100.77512299
43TAOK10.74509884
44RIPK40.74321230
45TESK20.73447955
46MATK0.72244129
47NEK60.71613074
48MAP2K20.71178309
49IKBKE0.70907186
50PRPF4B0.69455604
51BMPR20.68688862
52GRK60.67219993
53MAP4K10.66559487
54DAPK20.63281328
55STK160.61835968
56KIT0.57058508
57ERBB20.54585063
58PRKCQ0.54205426
59PDK10.52438626
60CASK0.49843061
61TNIK0.49786006
62MAP2K60.49536978
63STK30.48056720
64PRKCA0.46224413
65PRKACG0.46005081
66INSRR0.44695178
67TAOK30.44068889
68HIPK20.43582829
69JAK30.42453135
70PRKCE0.41757153
71MAPKAPK30.41482588
72PAK40.41433740
73JAK20.40977548
74MAP3K110.40788826
75LRRK20.38595324
76CSK0.38471198
77PRKCD0.37085749
78SRC0.36355116
79DAPK10.35826539
80PRKAA20.35799290
81ERBB30.34905161
82CDK190.33636635
83BMX0.32833373
84PTK20.32705133
85MAPK110.30761514
86STK38L0.29910533
87NME10.29384196
88IRAK40.29083412
89ABL20.27888577
90YES10.26830641
91ROCK10.26367751
92MELK0.25159208
93PDGFRB0.24847783
94MAPK70.24722400
95PDGFRA0.23489891
96IGF1R0.22929276
97ADRBK20.22791546
98DAPK30.21050279
99RET0.19737433
100FYN0.19066185

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.83294575
2Pancreatic secretion_Homo sapiens_hsa049725.61506658
3Protein digestion and absorption_Homo sapiens_hsa049744.71099622
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.49504585
5Vitamin digestion and absorption_Homo sapiens_hsa049773.21756648
6Renin-angiotensin system_Homo sapiens_hsa046143.01833245
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67750363
8Glycerolipid metabolism_Homo sapiens_hsa005612.50374570
9Linoleic acid metabolism_Homo sapiens_hsa005912.28474730
10Sulfur metabolism_Homo sapiens_hsa009202.08307910
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.06561457
12Mineral absorption_Homo sapiens_hsa049781.83923662
13Starch and sucrose metabolism_Homo sapiens_hsa005001.81930521
14Arginine biosynthesis_Homo sapiens_hsa002201.79947647
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66604963
16Fructose and mannose metabolism_Homo sapiens_hsa000511.55817333
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54906320
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53513676
19Arachidonic acid metabolism_Homo sapiens_hsa005901.53247943
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47078859
21Ether lipid metabolism_Homo sapiens_hsa005651.45896815
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.39459321
23Chemical carcinogenesis_Homo sapiens_hsa052041.38348416
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.30834701
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29642768
26Histidine metabolism_Homo sapiens_hsa003401.26219885
27Asthma_Homo sapiens_hsa053101.20268329
28Caffeine metabolism_Homo sapiens_hsa002321.19367360
29Retinol metabolism_Homo sapiens_hsa008301.17585809
30Glutathione metabolism_Homo sapiens_hsa004801.16299695
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14093249
32Galactose metabolism_Homo sapiens_hsa000521.09862173
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.07711357
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.05227253
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02079908
36Staphylococcus aureus infection_Homo sapiens_hsa051500.97586279
37Arginine and proline metabolism_Homo sapiens_hsa003300.95170648
38Fatty acid degradation_Homo sapiens_hsa000710.92718905
39Bile secretion_Homo sapiens_hsa049760.92114361
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88305150
41Type I diabetes mellitus_Homo sapiens_hsa049400.82798883
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.78865270
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78068659
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77521326
45Allograft rejection_Homo sapiens_hsa053300.77488491
46PPAR signaling pathway_Homo sapiens_hsa033200.73162588
47Autoimmune thyroid disease_Homo sapiens_hsa053200.73119478
48Tryptophan metabolism_Homo sapiens_hsa003800.68443539
49Graft-versus-host disease_Homo sapiens_hsa053320.67564633
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66745721
51Thyroid hormone synthesis_Homo sapiens_hsa049180.60910655
52Influenza A_Homo sapiens_hsa051640.60331356
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56612006
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.54593549
55Other glycan degradation_Homo sapiens_hsa005110.53496318
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52327618
57Hepatitis C_Homo sapiens_hsa051600.48358434
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47424990
59Pertussis_Homo sapiens_hsa051330.47101714
60Sphingolipid metabolism_Homo sapiens_hsa006000.46603640
61Leishmaniasis_Homo sapiens_hsa051400.44586820
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43404795
63Complement and coagulation cascades_Homo sapiens_hsa046100.40879537
64Peroxisome_Homo sapiens_hsa041460.38052388
65Antigen processing and presentation_Homo sapiens_hsa046120.37912536
66Vibrio cholerae infection_Homo sapiens_hsa051100.34547978
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32148473
68Rheumatoid arthritis_Homo sapiens_hsa053230.31792293
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26745169
70Tight junction_Homo sapiens_hsa045300.26462742
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25423800
72Folate biosynthesis_Homo sapiens_hsa007900.23269091
73Fatty acid metabolism_Homo sapiens_hsa012120.23134031
74Pentose phosphate pathway_Homo sapiens_hsa000300.23039814
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22539088
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.20917863
77Toxoplasmosis_Homo sapiens_hsa051450.20583849
78Metabolic pathways_Homo sapiens_hsa011000.16446349
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.15148744
80Insulin secretion_Homo sapiens_hsa049110.15147122
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15103747
82TNF signaling pathway_Homo sapiens_hsa046680.14129780
83Hematopoietic cell lineage_Homo sapiens_hsa046400.13909109
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.13509217
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.12967915
86Butanoate metabolism_Homo sapiens_hsa006500.12540774
87N-Glycan biosynthesis_Homo sapiens_hsa005100.12309559
88Renin secretion_Homo sapiens_hsa049240.11868097
89Viral myocarditis_Homo sapiens_hsa054160.10835282
90Tyrosine metabolism_Homo sapiens_hsa003500.10454233
91Fatty acid elongation_Homo sapiens_hsa000620.09118729
92Steroid biosynthesis_Homo sapiens_hsa001000.08484395
93Salmonella infection_Homo sapiens_hsa051320.08386468
94Chemokine signaling pathway_Homo sapiens_hsa040620.08375496
95Insulin resistance_Homo sapiens_hsa049310.07647307
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.06470171
97Phenylalanine metabolism_Homo sapiens_hsa003600.05784620
98ABC transporters_Homo sapiens_hsa020100.02886871
99Tuberculosis_Homo sapiens_hsa051520.02277563
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.02237118

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