REG1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)8.40125163
2digestion (GO:0007586)7.93495154
3angiotensin maturation (GO:0002003)7.81400824
4intestinal cholesterol absorption (GO:0030299)7.78346650
5cobalamin metabolic process (GO:0009235)7.31756852
6regulation of cellular extravasation (GO:0002691)7.29150808
7negative regulation of epidermal cell differentiation (GO:0045605)7.04685450
8antibacterial humoral response (GO:0019731)6.89925998
9antimicrobial humoral response (GO:0019730)6.59636001
10regulation of guanylate cyclase activity (GO:0031282)6.02538443
11transcytosis (GO:0045056)5.65163277
12regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.59999029
13maintenance of gastrointestinal epithelium (GO:0030277)5.54252197
14negative regulation of epidermis development (GO:0045683)5.23896742
15phosphatidylserine acyl-chain remodeling (GO:0036150)5.17847670
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.13069836
17NADH metabolic process (GO:0006734)4.95351557
18phosphatidylinositol acyl-chain remodeling (GO:0036149)4.89580280
19positive regulation of pseudopodium assembly (GO:0031274)4.80816294
20positive regulation of guanylate cyclase activity (GO:0031284)4.69260098
21glycolipid catabolic process (GO:0019377)4.58362277
22positive regulation of respiratory burst (GO:0060267)4.53154985
23regulation of pseudopodium assembly (GO:0031272)4.32306082
24digestive system process (GO:0022600)4.30311506
25ceramide catabolic process (GO:0046514)4.25772997
26regulation of keratinocyte differentiation (GO:0045616)4.19869905
27regulation of bile acid biosynthetic process (GO:0070857)4.18655775
28regulation of keratinocyte proliferation (GO:0010837)4.09620463
29regulation of phospholipase A2 activity (GO:0032429)4.09302524
30epithelial structure maintenance (GO:0010669)4.03793009
31membrane lipid catabolic process (GO:0046466)4.02815811
32peptide catabolic process (GO:0043171)3.95772067
33icosanoid secretion (GO:0032309)3.94886820
34arachidonic acid secretion (GO:0050482)3.94886820
35regulation of vitamin metabolic process (GO:0030656)3.92204188
36innate immune response in mucosa (GO:0002227)3.91505382
37peptide hormone processing (GO:0016486)3.85447812
38positive regulation of glycoprotein biosynthetic process (GO:0010560)3.74087402
39icosanoid transport (GO:0071715)3.73192140
40fatty acid derivative transport (GO:1901571)3.73192140
41regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.67145791
42endocrine process (GO:0050886)3.67145791
43regulation of systemic arterial blood pressure by hormone (GO:0001990)3.67145791
44fructose metabolic process (GO:0006000)3.63638465
45regulation of cGMP biosynthetic process (GO:0030826)3.62947581
46hormone catabolic process (GO:0042447)3.60126269
47calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.57918611
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57843439
49phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.52346087
50diacylglycerol metabolic process (GO:0046339)3.50959379
51phosphatidylcholine acyl-chain remodeling (GO:0036151)3.50292509
52sphingolipid catabolic process (GO:0030149)3.49279431
53acute-phase response (GO:0006953)3.48766695
54positive regulation of glycoprotein metabolic process (GO:1903020)3.47943836
55phosphatidylserine metabolic process (GO:0006658)3.47628900
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.44395526
57lipoprotein transport (GO:0042953)3.43192810
58regulation of systemic arterial blood pressure (GO:0003073)3.42625683
59epoxygenase P450 pathway (GO:0019373)3.41966095
60complement activation, classical pathway (GO:0006958)3.39102449
61urea cycle (GO:0000050)3.39003594
62glomerular filtration (GO:0003094)3.38279251
63glucuronate metabolic process (GO:0019585)3.32989787
64uronic acid metabolic process (GO:0006063)3.32989787
65cellular glucuronidation (GO:0052695)3.32281225
66leukotriene metabolic process (GO:0006691)3.30940707
67cellular response to cadmium ion (GO:0071276)3.28831424
68antigen processing and presentation of endogenous antigen (GO:0019883)3.26423441
69phosphatidic acid biosynthetic process (GO:0006654)3.25855540
70phosphatidic acid metabolic process (GO:0046473)3.25855540
71mucosal immune response (GO:0002385)3.25760504
72arginine metabolic process (GO:0006525)3.24997615
73regulation of dendritic cell antigen processing and presentation (GO:0002604)3.24314946
74receptor guanylyl cyclase signaling pathway (GO:0007168)3.23882114
75doxorubicin metabolic process (GO:0044598)3.18290044
76daunorubicin metabolic process (GO:0044597)3.18290044
77polyketide metabolic process (GO:0030638)3.18290044
78glycoside metabolic process (GO:0016137)3.14766732
79urea metabolic process (GO:0019627)3.13178843
80alditol phosphate metabolic process (GO:0052646)3.13131629
81vitamin A metabolic process (GO:0006776)3.12541569
82adhesion of symbiont to host cell (GO:0044650)3.11583674
83virion attachment to host cell (GO:0019062)3.11583674
84renal filtration (GO:0097205)3.08277189
85leukotriene biosynthetic process (GO:0019370)3.07558775
86glycosphingolipid catabolic process (GO:0046479)3.07436980
87fat-soluble vitamin biosynthetic process (GO:0042362)3.07074762
88very-low-density lipoprotein particle assembly (GO:0034379)3.04260200
89organ or tissue specific immune response (GO:0002251)3.00916370
90cyclooxygenase pathway (GO:0019371)3.00360275
91regulation of cGMP metabolic process (GO:0030823)2.95303122
92regulation of cholesterol homeostasis (GO:2000188)2.95026252
93regulation of respiratory burst (GO:0060263)2.94769634
94GDP-mannose metabolic process (GO:0019673)2.93804211
95eosinophil chemotaxis (GO:0048245)2.92506248
96negative regulation of hormone metabolic process (GO:0032351)2.91074672
97arginine catabolic process (GO:0006527)2.90215554
98regulation of triglyceride catabolic process (GO:0010896)2.87806547
99nitrogen cycle metabolic process (GO:0071941)2.86134430
100regulation of necrotic cell death (GO:0010939)2.83478197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.43813346
2CDX2_20551321_ChIP-Seq_CACO-2_Human4.28793162
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.59825169
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.49229786
5GATA4_25053715_ChIP-Seq_YYC3_Human3.27222832
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.15570292
7HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.04622702
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93583765
9GATA6_25053715_ChIP-Seq_YYC3_Human2.72414051
10SOX2_20726797_ChIP-Seq_SW620_Human2.61402032
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.58002663
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.38419676
13RXR_22158963_ChIP-Seq_LIVER_Mouse2.32438322
14TCF4_18268006_ChIP-ChIP_LS174T_Human2.16950290
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.16668984
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.13426700
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11482736
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.10516000
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.03997322
20BP1_19119308_ChIP-ChIP_Hs578T_Human1.99702017
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.93606101
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.91650052
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87317292
24GATA1_22025678_ChIP-Seq_K562_Human1.86298607
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76708521
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74879794
27EGR1_19032775_ChIP-ChIP_M12_Human1.74165491
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.73925868
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.73470907
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72932063
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.65661299
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60261140
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58660725
34PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.55415263
35AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.54421192
36FOXA1_25552417_ChIP-Seq_VCAP_Human1.46107806
37NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.45543607
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.39618583
39FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.38621416
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38166281
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.36729669
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.34164542
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.33912827
44ESR1_21235772_ChIP-Seq_MCF-7_Human1.33517233
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.31274610
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.30938219
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28788137
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28466385
49CLOCK_20551151_ChIP-Seq_293T_Human1.26928090
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23359453
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21943001
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.20836199
53LXR_22292898_ChIP-Seq_THP-1_Human1.20824640
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19827171
55RACK7_27058665_Chip-Seq_MCF-7_Human1.06499653
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06193549
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.05437240
58HNF4A_19822575_ChIP-Seq_HepG2_Human1.05402089
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04500923
60GATA3_24758297_ChIP-Seq_MCF-7_Human1.03907694
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.03845628
62P63_26484246_Chip-Seq_KERATINOCYTES_Human1.02947177
63* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02353165
64SA1_27219007_Chip-Seq_Bcells_Human1.02118871
65KLF5_25053715_ChIP-Seq_YYC3_Human1.00725203
66GATA2_19941826_ChIP-Seq_K562_Human1.00341488
67FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99651578
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98822835
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98822835
70KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98822835
71CDX2_22108803_ChIP-Seq_LS180_Human0.98601426
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97219965
73BCOR_27268052_Chip-Seq_Bcells_Human0.96254245
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.96057811
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93588210
76CJUN_26792858_Chip-Seq_BT549_Human0.93259673
77Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91397191
78SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89940621
79CEBPB_22108803_ChIP-Seq_LS180_Human0.88269317
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87546838
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86566715
82SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86489049
83EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.82700746
84STAT1_20625510_ChIP-Seq_HELA_Human0.82655995
85IRF8_27001747_Chip-Seq_BMDM_Mouse0.82045673
86GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81584655
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78318747
88GATA2_21666600_ChIP-Seq_HMVEC_Human0.77986400
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77480103
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76005006
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75867634
92TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75493846
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74683068
94HNFA_21074721_ChIP-Seq_CACO-2_Human0.74276711
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.73845777
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73717706
97GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73559040
98NANOG_20526341_ChIP-Seq_ESCs_Human0.72769580
99RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72034727
100PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.70547706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption7.39590627
2MP0005360_urolithiasis5.86725549
3MP0005365_abnormal_bile_salt4.49847283
4MP0003868_abnormal_feces_composition4.35764155
5MP0010234_abnormal_vibrissa_follicle3.39381631
6MP0005085_abnormal_gallbladder_physiolo3.37897177
7MP0002139_abnormal_hepatobiliary_system3.27781917
8MP0009379_abnormal_foot_pigmentation3.06151656
9MP0010155_abnormal_intestine_physiology2.90341542
10MP0001873_stomach_inflammation2.71267936
11MP0003183_abnormal_peptide_metabolism2.65535651
12MP0009840_abnormal_foam_cell2.57489775
13MP0004019_abnormal_vitamin_homeostasis2.41522712
14MP0002876_abnormal_thyroid_physiology2.41246393
15MP0010352_gastrointestinal_tract_polyps2.31669187
16MP0004264_abnormal_extraembryonic_tissu2.27181471
17MP0003866_abnormal_defecation2.22618547
18MP0004858_abnormal_nervous_system2.14660952
19MP0003300_gastrointestinal_ulcer2.02136909
20MP0001664_abnormal_digestion1.96760607
21MP0010329_abnormal_lipoprotein_level1.80451665
22MP0005166_decreased_susceptibility_to1.80221855
23MP0004782_abnormal_surfactant_physiolog1.77474848
24MP0004147_increased_porphyrin_level1.72919887
25MP0005409_darkened_coat_color1.65434477
26MP0002138_abnormal_hepatobiliary_system1.58011626
27MP0005332_abnormal_amino_acid1.54863191
28MP0000490_abnormal_crypts_of1.51464862
29MP0009643_abnormal_urine_homeostasis1.47250673
30MP0010386_abnormal_urinary_bladder1.45506662
31MP0005448_abnormal_energy_balance1.43244560
32MP0000678_abnormal_parathyroid_gland1.41763182
33MP0000462_abnormal_digestive_system1.40682250
34MP0001663_abnormal_digestive_system1.40160734
35MP0003436_decreased_susceptibility_to1.36488999
36MP0000477_abnormal_intestine_morphology1.32699330
37MP0003724_increased_susceptibility_to1.31390328
38MP0003329_amyloid_beta_deposits1.27959419
39MP0001845_abnormal_inflammatory_respons1.26967515
40MP0002118_abnormal_lipid_homeostasis1.26527199
41MP0001756_abnormal_urination1.26425252
42MP0003959_abnormal_lean_body1.21765779
43MP0000538_abnormal_urinary_bladder1.21418807
44MP0005381_digestive/alimentary_phenotyp1.19109495
45MP0003252_abnormal_bile_duct1.17287155
46MP0005387_immune_system_phenotype1.14959444
47MP0001790_abnormal_immune_system1.14959444
48MP0001765_abnormal_ion_homeostasis1.10720141
49MP0009785_altered_susceptibility_to1.10433727
50MP0008004_abnormal_stomach_pH1.01715818
51MP0000465_gastrointestinal_hemorrhage1.01018799
52MP0002136_abnormal_kidney_physiology0.99921079
53MP0002796_impaired_skin_barrier0.99222042
54MP0005025_abnormal_response_to0.96778053
55MP0002166_altered_tumor_susceptibility0.96684556
56MP0005636_abnormal_mineral_homeostasis0.93366597
57MP0000604_amyloidosis0.92942931
58MP0001764_abnormal_homeostasis0.91929495
59MP0004043_abnormal_pH_regulation0.91009269
60MP0001533_abnormal_skeleton_physiology0.90658024
61MP0002822_catalepsy0.86013845
62MP0001501_abnormal_sleep_pattern0.85931369
63MP0002693_abnormal_pancreas_physiology0.85245391
64MP0003806_abnormal_nucleotide_metabolis0.84626955
65MP0001835_abnormal_antigen_presentation0.84140545
66MP0008469_abnormal_protein_level0.84025377
67MP0003075_altered_response_to0.82951799
68MP0005319_abnormal_enzyme/_coenzyme0.81026123
69MP0001188_hyperpigmentation0.80724650
70MP0005584_abnormal_enzyme/coenzyme_acti0.80477059
71MP0003879_abnormal_hair_cell0.79804480
72MP0004947_skin_inflammation0.76861400
73MP0002078_abnormal_glucose_homeostasis0.76689243
74MP0001881_abnormal_mammary_gland0.75721546
75MP0002909_abnormal_adrenal_gland0.75288849
76MP0005671_abnormal_response_to0.73962972
77MP0000537_abnormal_urethra_morphology0.72245448
78MP0002098_abnormal_vibrissa_morphology0.71756492
79MP0000609_abnormal_liver_physiology0.71401641
80MP0004270_analgesia0.70780247
81MP0002896_abnormal_bone_mineralization0.69104107
82MP0005334_abnormal_fat_pad0.69005312
83MP0000685_abnormal_immune_system0.68846595
84MP0003953_abnormal_hormone_level0.67352694
85MP0006082_CNS_inflammation0.66939427
86MP0003045_fibrosis0.65588192
87MP0002006_tumorigenesis0.63939066
88MP0002971_abnormal_brown_adipose0.63189965
89MP0009642_abnormal_blood_homeostasis0.63075017
90MP0001485_abnormal_pinna_reflex0.61836305
91MP0002148_abnormal_hypersensitivity_rea0.60061784
92MP0005165_increased_susceptibility_to0.60039886
93MP0002277_abnormal_respiratory_mucosa0.59746369
94MP0005220_abnormal_exocrine_pancreas0.59279978
95MP0000681_abnormal_thyroid_gland0.58908263
96MP0009333_abnormal_splenocyte_physiolog0.58554248
97MP0009764_decreased_sensitivity_to0.58427014
98MP0005000_abnormal_immune_tolerance0.57549876
99MP0005058_abnormal_lysosome_morphology0.57290570
100MP0005452_abnormal_adipose_tissue0.56598895

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)9.79936555
2Fat malabsorption (HP:0002630)9.15855491
3Abnormality of glutamine family amino acid metabolism (HP:0010902)8.14643568
4Malnutrition (HP:0004395)6.41759875
5Exocrine pancreatic insufficiency (HP:0001738)6.06448772
6Abnormality of proline metabolism (HP:0010907)5.58375719
7Hydroxyprolinuria (HP:0003080)5.58375719
8Systemic lupus erythematosus (HP:0002725)5.26754069
9Pancreatitis (HP:0001733)5.10009230
10Ileus (HP:0002595)4.73819256
11Hypoproteinemia (HP:0003075)4.54282428
12Chronic diarrhea (HP:0002028)4.20943419
13Abnormality of the vitamin B12 metabolism (HP:0004341)3.79212659
14Abnormality of vitamin B metabolism (HP:0004340)3.62930623
15Hypobetalipoproteinemia (HP:0003563)3.54511917
16Glomerulonephritis (HP:0000099)3.51072380
17Villous atrophy (HP:0011473)3.48231828
18Abnormality of small intestinal villus morphology (HP:0011472)3.48231828
19Hyperphosphatemia (HP:0002905)3.13845579
20Abnormality of vitamin metabolism (HP:0100508)3.04474180
21Complement deficiency (HP:0004431)3.02860671
22Congenital sensorineural hearing impairment (HP:0008527)3.00287971
23Eczematoid dermatitis (HP:0000976)2.97141826
24Abnormality of complement system (HP:0005339)2.94519356
25Abnormality of monocarboxylic acid metabolism (HP:0010996)2.91846716
26Glycosuria (HP:0003076)2.89510939
27Abnormality of urine glucose concentration (HP:0011016)2.89510939
28Acanthocytosis (HP:0001927)2.83333740
29Hyperparathyroidism (HP:0000843)2.80673670
30Abnormality of the pleura (HP:0002103)2.76625666
31Nephritis (HP:0000123)2.74418558
32Widely patent fontanelles and sutures (HP:0004492)2.72941451
33Pigmentary retinal degeneration (HP:0001146)2.63105531
34Right ventricular cardiomyopathy (HP:0011663)2.58629014
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.54662435
36Nausea (HP:0002018)2.53547763
37Symptomatic seizures (HP:0011145)2.48470016
38Decreased circulating renin level (HP:0003351)2.48009151
39Proximal tubulopathy (HP:0000114)2.47378390
40Hyperammonemia (HP:0001987)2.45540736
41Hypophosphatemia (HP:0002148)2.41305492
42Abdominal distention (HP:0003270)2.36753195
43Alkalosis (HP:0001948)2.31735250
44Nephrolithiasis (HP:0000787)2.31330078
45Hyperuricemia (HP:0002149)2.30560971
46Increased purine levels (HP:0004368)2.30560971
47Hypotension (HP:0002615)2.25670342
48Rectal prolapse (HP:0002035)2.22617145
49Facial shape deformation (HP:0011334)2.20310338
50Potter facies (HP:0002009)2.20310338
51Xanthomatosis (HP:0000991)2.18251154
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18115812
53Abnormality of renin-angiotensin system (HP:0000847)2.14666147
54Metabolic alkalosis (HP:0200114)2.14107221
55Gout (HP:0001997)2.12666241
56Wide cranial sutures (HP:0010537)2.10218604
57Hyperactive renin-angiotensin system (HP:0000841)2.09667467
58Late onset (HP:0003584)2.09531835
59Posterior subcapsular cataract (HP:0007787)2.08415088
60Hemorrhage of the eye (HP:0011885)2.07350560
61Abnormality of glycine metabolism (HP:0010895)2.06943056
62Abnormality of serine family amino acid metabolism (HP:0010894)2.06943056
63Confusion (HP:0001289)2.05360559
64Hyperglycinuria (HP:0003108)2.02037206
65Gastrointestinal dysmotility (HP:0002579)2.01390214
66Hyperphosphaturia (HP:0003109)2.01342364
67Abnormality of purine metabolism (HP:0004352)2.00815429
68Focal segmental glomerulosclerosis (HP:0000097)2.00219606
69Dicarboxylic aciduria (HP:0003215)1.98540727
70Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98540727
71Vascular calcification (HP:0004934)1.98234235
72Growth hormone excess (HP:0000845)1.95958688
73Thin bony cortex (HP:0002753)1.95281564
74Abnormal glucose tolerance (HP:0001952)1.93939573
75Abdominal pain (HP:0002027)1.91908921
76Hypoglycemic seizures (HP:0002173)1.90370479
77Abnormal biliary tract morphology (HP:0012440)1.88749469
78Cerebral palsy (HP:0100021)1.85913432
79Hypoglycemic coma (HP:0001325)1.84589298
80Gingivitis (HP:0000230)1.84171848
81Renal tubular acidosis (HP:0001947)1.83795802
82Abnormality of nucleobase metabolism (HP:0010932)1.83543046
83Abnormal urine phosphate concentration (HP:0012599)1.80383917
84Megaloblastic anemia (HP:0001889)1.79565803
85Metabolic acidosis (HP:0001942)1.77960224
86Goiter (HP:0000853)1.74686838
87Abnormality of magnesium homeostasis (HP:0004921)1.73855658
88Ventricular fibrillation (HP:0001663)1.73761084
89Cardiovascular calcification (HP:0011915)1.73694938
90Tetraparesis (HP:0002273)1.68880314
91Hyperinsulinemic hypoglycemia (HP:0000825)1.68830407
92Protuberant abdomen (HP:0001538)1.68815549
93Gastrointestinal stroma tumor (HP:0100723)1.67869283
94Bone pain (HP:0002653)1.67742018
95Pili torti (HP:0003777)1.65073366
96Vacuolated lymphocytes (HP:0001922)1.63896812
97Rhabdomyolysis (HP:0003201)1.63420884
98Petechiae (HP:0000967)1.63299574
99Glomerulosclerosis (HP:0000096)1.62281435
100Hypoalbuminemia (HP:0003073)1.62159556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.76658334
2ACVR1B4.60027401
3MST1R4.47790881
4LMTK23.99352416
5PRKG23.42512939
6RIPK13.37467757
7EPHA33.21255805
8PDK23.08345664
9FGFR42.86944188
10EPHA22.77824334
11MAP3K122.43590535
12STK392.34871802
13EPHB12.30494738
14TYK22.01032052
15OXSR11.89938654
16STK241.69683080
17MAP3K101.67421705
18MET1.58367753
19NLK1.56299374
20FGFR31.53129103
21EPHB21.46962918
22MAP3K11.44319401
23MYLK1.39223031
24TESK11.31503674
25MAP3K21.31093557
26IRAK11.26226056
27FER1.25147482
28PTK61.24344596
29MST41.16447641
30JAK11.14961347
31DDR21.12808877
32PRPF4B1.11857475
33TESK21.09600857
34MAP4K11.07903184
35TGFBR21.06199212
36MAP3K141.04801555
37CDC42BPA1.01550283
38MAP3K31.01536172
39GRK61.00299686
40RIPK40.97962740
41GRK10.93486458
42MATK0.89261127
43PDPK10.87508561
44TBK10.87116616
45BMPR20.86759775
46MAP2K20.84189197
47ZAP700.77994203
48KIT0.75214680
49IKBKE0.71965546
50TAOK10.70792477
51PIK3CA0.69419544
52NEK60.67797106
53PDGFRA0.65409610
54ERBB20.63638153
55TNIK0.60441031
56JAK30.60413591
57PAK40.58140198
58PDK10.57379356
59EIF2AK30.54091716
60JAK20.52959902
61BMX0.51462588
62PRKACG0.48813260
63MAP2K60.48285980
64PRKCA0.47054451
65LRRK20.45976106
66CSK0.45000939
67DAPK20.44774074
68RET0.44051145
69PRKCQ0.43355545
70CASK0.42826341
71MAP3K110.42245620
72YES10.40163654
73STK160.39817877
74SRC0.39319735
75PTK20.37488055
76IRAK40.36095506
77MAPK110.35200965
78HIPK20.35061253
79CDK190.34737744
80FYN0.32940231
81PRKAA20.31372928
82TAOK30.31094131
83PRKCD0.30769467
84PRKCZ0.30636336
85PASK0.29512592
86MELK0.28789586
87KSR20.26488607
88CSF1R0.26331398
89IGF1R0.25762690
90ERBB30.25546462
91MAPK70.22700252
92DAPK10.21961569
93ABL20.21751529
94CAMK2D0.21522146
95DAPK30.20374673
96PDGFRB0.20138943
97ROCK10.20085165
98LYN0.20029515
99PRKCE0.18918180
100IRAK30.17571897

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.77613318
2Pancreatic secretion_Homo sapiens_hsa049724.73315157
3Protein digestion and absorption_Homo sapiens_hsa049744.26791496
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.74112492
5Vitamin digestion and absorption_Homo sapiens_hsa049773.49620533
6Renin-angiotensin system_Homo sapiens_hsa046143.33099583
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.56422420
8Glycerolipid metabolism_Homo sapiens_hsa005612.41309197
9Linoleic acid metabolism_Homo sapiens_hsa005912.17937615
10Arginine biosynthesis_Homo sapiens_hsa002202.04860057
11Mineral absorption_Homo sapiens_hsa049782.04793310
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93403724
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.82631375
14Starch and sucrose metabolism_Homo sapiens_hsa005001.73954317
15Sulfur metabolism_Homo sapiens_hsa009201.72605222
16Fructose and mannose metabolism_Homo sapiens_hsa000511.68137952
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.55114788
18Asthma_Homo sapiens_hsa053101.52649051
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.50264651
20Arachidonic acid metabolism_Homo sapiens_hsa005901.47641835
21Histidine metabolism_Homo sapiens_hsa003401.44596373
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42484218
23Ether lipid metabolism_Homo sapiens_hsa005651.40942358
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35907241
25Chemical carcinogenesis_Homo sapiens_hsa052041.26631881
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.24226594
27Caffeine metabolism_Homo sapiens_hsa002321.22404550
28Galactose metabolism_Homo sapiens_hsa000521.20487512
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19986395
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18304853
31Staphylococcus aureus infection_Homo sapiens_hsa051501.16686279
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15852524
33Retinol metabolism_Homo sapiens_hsa008301.08507946
34Glutathione metabolism_Homo sapiens_hsa004801.07518464
35Type I diabetes mellitus_Homo sapiens_hsa049401.05928399
36Arginine and proline metabolism_Homo sapiens_hsa003301.05259486
37Allograft rejection_Homo sapiens_hsa053301.03282365
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99315009
39Autoimmune thyroid disease_Homo sapiens_hsa053200.97487441
40Bile secretion_Homo sapiens_hsa049760.96252427
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95540876
42Fatty acid degradation_Homo sapiens_hsa000710.93254481
43Graft-versus-host disease_Homo sapiens_hsa053320.91447363
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.90728812
45PPAR signaling pathway_Homo sapiens_hsa033200.90633239
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82890227
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81580899
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.80277885
49Tryptophan metabolism_Homo sapiens_hsa003800.74529945
50Leishmaniasis_Homo sapiens_hsa051400.62490105
51Other glycan degradation_Homo sapiens_hsa005110.62263246
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62157825
53Antigen processing and presentation_Homo sapiens_hsa046120.58980461
54Glycerophospholipid metabolism_Homo sapiens_hsa005640.58412947
55Thyroid hormone synthesis_Homo sapiens_hsa049180.56984773
56Pertussis_Homo sapiens_hsa051330.56381271
57Influenza A_Homo sapiens_hsa051640.54711663
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53198759
59Sphingolipid metabolism_Homo sapiens_hsa006000.50432976
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49710835
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49534172
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47065583
63Folate biosynthesis_Homo sapiens_hsa007900.41443595
64Hepatitis C_Homo sapiens_hsa051600.40618482
65Complement and coagulation cascades_Homo sapiens_hsa046100.39273373
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36263841
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36040366
68Peroxisome_Homo sapiens_hsa041460.35668509
69Toxoplasmosis_Homo sapiens_hsa051450.33889207
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30964999
71Rheumatoid arthritis_Homo sapiens_hsa053230.30135293
72Fatty acid metabolism_Homo sapiens_hsa012120.29533313
73Viral myocarditis_Homo sapiens_hsa054160.29060803
74Vibrio cholerae infection_Homo sapiens_hsa051100.28687589
75Hematopoietic cell lineage_Homo sapiens_hsa046400.26334555
76Pentose phosphate pathway_Homo sapiens_hsa000300.25501783
77Renin secretion_Homo sapiens_hsa049240.23945748
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.23263613
79Insulin secretion_Homo sapiens_hsa049110.21030617
80Tight junction_Homo sapiens_hsa045300.19506860
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.17941377
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.17909998
83Chemokine signaling pathway_Homo sapiens_hsa040620.16364539
84Phenylalanine metabolism_Homo sapiens_hsa003600.16087755
85Tuberculosis_Homo sapiens_hsa051520.14629278
86TNF signaling pathway_Homo sapiens_hsa046680.12219523
87Metabolic pathways_Homo sapiens_hsa011000.12070302
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.10297726
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.10220977
90Amoebiasis_Homo sapiens_hsa051460.10039723
91Salmonella infection_Homo sapiens_hsa051320.09708635
92Fatty acid elongation_Homo sapiens_hsa000620.09633656
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.09141921
94Insulin resistance_Homo sapiens_hsa049310.08760576
95N-Glycan biosynthesis_Homo sapiens_hsa005100.08579349
96Tyrosine metabolism_Homo sapiens_hsa003500.07920127
97Butanoate metabolism_Homo sapiens_hsa006500.06870883
98Carbon metabolism_Homo sapiens_hsa012000.05883643
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.04912106
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.04048607

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