ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of epidermis development (GO:0045683)	9.53529240
2	neutrophil mediated immunity (GO:0002446)	9.44366159
3	intestinal absorption (GO:0050892)	8.50582700
4	icosanoid secretion (GO:0032309)	8.42137705
5	arachidonic acid secretion (GO:0050482)	8.42137705
6	phosphatidylinositol acyl-chain remodeling (GO:0036149)	8.31958406
7	phosphatidylserine acyl-chain remodeling (GO:0036150)	8.14231519
8	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	7.82961506
9	cholesterol catabolic process (GO:0006707)	7.37411795
10	sterol catabolic process (GO:0016127)	7.37411795
11	regulation of keratinocyte differentiation (GO:0045616)	7.19408153
12	myeloid leukocyte mediated immunity (GO:0002444)	6.92146357
13	icosanoid transport (GO:0071715)	6.91382904
14	fatty acid derivative transport (GO:1901571)	6.91382904
15	innate immune response in mucosa (GO:0002227)	6.58826248
16	regulation of keratinocyte proliferation (GO:0010837)	6.50445235
17	membrane lipid catabolic process (GO:0046466)	6.44870559
18	glycolipid catabolic process (GO:0019377)	6.38565307
19	ceramide catabolic process (GO:0046514)	6.09157567
20	mucosal immune response (GO:0002385)	6.02077638
21	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	5.93260667
22	leukotriene biosynthetic process (GO:0019370)	5.89134605
23	organ or tissue specific immune response (GO:0002251)	5.48342273
24	tetrapyrrole metabolic process (GO:0033013)	5.45092887
25	antibacterial humoral response (GO:0019731)	5.24877963
26	phosphatidylserine metabolic process (GO:0006658)	5.09808150
27	phosphatidylcholine acyl-chain remodeling (GO:0036151)	5.08383013
28	antimicrobial humoral response (GO:0019730)	4.85027430
29	regulation of cholesterol homeostasis (GO:2000188)	4.70206322
30	phosphatidic acid biosynthetic process (GO:0006654)	4.67254367
31	phosphatidic acid metabolic process (GO:0046473)	4.67254367
32	atrioventricular valve morphogenesis (GO:0003181)	4.32057276
33	defense response to Gram-positive bacterium (GO:0050830)	4.25839487
34	cellular protein catabolic process (GO:0044257)	4.24816791
35	negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)	4.23884928
36	water-soluble vitamin metabolic process (GO:0006767)	4.16419635
37	protein retention in ER lumen (GO:0006621)	4.16300400
38	mitochondrial calcium ion transport (GO:0006851)	4.12369836
39	alditol phosphate metabolic process (GO:0052646)	4.10701923
40	negative regulation of epithelial cell differentiation (GO:0030857)	4.05988826
41	regulation of epidermal cell differentiation (GO:0045604)	4.02822785
42	cellular response to zinc ion (GO:0071294)	3.91902040
43	acute-phase response (GO:0006953)	3.90045105
44	phosphatidylglycerol metabolic process (GO:0046471)	3.87151147
45	steroid catabolic process (GO:0006706)	3.71704263
46	leukotriene metabolic process (GO:0006691)	3.70749457
47	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.69551240
48	peptidyl-proline hydroxylation (GO:0019511)	3.67587952
49	cholesterol transport (GO:0030301)	3.65563632
50	sterol transport (GO:0015918)	3.65563632
51	sphingolipid catabolic process (GO:0030149)	3.64187705
52	digestive system process (GO:0022600)	3.61088603
53	regulation of bile acid biosynthetic process (GO:0070857)	3.58058521
54	positive regulation of guanylate cyclase activity (GO:0031284)	3.47308483
55	mitochondrion distribution (GO:0048311)	3.42266474
56	positive regulation of calcium ion transport into cytosol (GO:0010524)	3.39567146
57	long-chain fatty acid transport (GO:0015909)	3.31939279
58	endothelial cell migration (GO:0043542)	3.26868104
59	regulation of guanylate cyclase activity (GO:0031282)	3.19729525
60	phototransduction, visible light (GO:0007603)	3.13783441
61	vitamin metabolic process (GO:0006766)	3.13196222
62	positive regulation of wound healing (GO:0090303)	3.12253975
63	regulation of acrosome reaction (GO:0060046)	3.08083354
64	multicellular organismal catabolic process (GO:0044243)	2.96227643
65	fatty acid derivative biosynthetic process (GO:1901570)	2.90641548
66	icosanoid biosynthetic process (GO:0046456)	2.90641548
67	retinoid metabolic process (GO:0001523)	2.81294001
68	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	2.77296866
69	endocardial cushion morphogenesis (GO:0003203)	2.76135789
70	detection of visible light (GO:0009584)	2.74010386
71	positive regulation of fibroblast proliferation (GO:0048146)	2.71543767
72	phospholipid catabolic process (GO:0009395)	2.71021308
73	defense response to Gram-negative bacterium (GO:0050829)	2.69051515
74	endocrine pancreas development (GO:0031018)	2.67040950
75	diterpenoid metabolic process (GO:0016101)	2.63838454
76	multicellular organismal metabolic process (GO:0044236)	2.60102530
77	regulation of macrophage chemotaxis (GO:0010758)	2.58378707
78	acute inflammatory response (GO:0002526)	2.53113325
79	protein hydroxylation (GO:0018126)	2.52640193
80	phototransduction (GO:0007602)	2.50861398
81	cholesterol metabolic process (GO:0008203)	2.47641460
82	exocrine pancreas development (GO:0031017)	2.46582843
83	extracellular matrix disassembly (GO:0022617)	2.41235984
84	regulation of epidermis development (GO:0045682)	2.40432778
85	glomerulus development (GO:0032835)	2.37761250
86	fatty acid transport (GO:0015908)	2.37354871
87	neutrophil chemotaxis (GO:0030593)	2.36789728
88	acid secretion (GO:0046717)	2.33738115
89	L-alpha-amino acid transmembrane transport (GO:1902475)	2.33688079
90	neutrophil migration (GO:1990266)	2.31511262
91	detection of light stimulus (GO:0009583)	2.31099393
92	epithelial cell migration (GO:0010631)	2.29661456
93	terpenoid metabolic process (GO:0006721)	2.28834427
94	unsaturated fatty acid biosynthetic process (GO:0006636)	2.28547087
95	intestinal cholesterol absorption (GO:0030299)	18.4607250
96	digestion (GO:0007586)	17.7940363
97	cobalamin metabolic process (GO:0009235)	17.1856120
98	regulation of phospholipase A2 activity (GO:0032429)	12.9557121
99	negative regulation of epidermal cell differentiation (GO:0045605)	12.4543926
100	transcytosis (GO:0045056)	11.7908569

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	3.72989417
2	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	3.72989417
3	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	3.72989417
4	EGR1_19032775_ChIP-ChIP_M12_Human	3.25714066
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	2.37154090
6	GATA4_25053715_ChIP-Seq_YYC3_Human	2.21160017
7	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	15.9999987
8	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.94348710
9	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.92706793
10	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.90214813
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.82449809
12	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.77249498
13	HTT_18923047_ChIP-ChIP_STHdh_Human	1.58117949
14	ETV1_20927104_ChIP-Seq_GIST48_Human	1.53158301
15	PHF8_20622853_ChIP-Seq_HELA_Human	1.46658045
16	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.44955954
17	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.44738878
18	NFYA_21822215_ChIP-Seq_K562_Human	1.43543292
19	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.40099299
20	ESET_19884257_ChIP-Seq_ESCs_Mouse	1.39755731
21	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.35359355
22	RBPJ_21746931_ChIP-Seq_IB4_Human	1.34985144
23	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.34760122
24	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.33408216
25	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.32695925
26	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29317695
27	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.28925743
28	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.28440212
29	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.26077752
30	GATA6_25053715_ChIP-Seq_YYC3_Human	1.24946550
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.24226464
32	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.23231577
33	NFYB_21822215_ChIP-Seq_K562_Human	1.18405904
34	ERA_21632823_ChIP-Seq_H3396_Human	1.15907598
35	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.15436250
36	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.12974277
37	TBL1_22424771_ChIP-Seq_293T_Human	1.03935257
38	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.02630220
39	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.02291901
40	VDR_22108803_ChIP-Seq_LS180_Human	1.01722130
41	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00882580
42	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.00727960
43	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.97745858
44	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.96933936
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.96643820
46	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.96346953
47	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.95624381
48	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.93353607
49	TP53_18474530_ChIP-ChIP_U2OS_Human	0.92574913
50	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.91431994
51	P300_19829295_ChIP-Seq_ESCs_Human	0.88224061
52	ER_23166858_ChIP-Seq_MCF-7_Human	0.88088856
53	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.86562738
54	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.86283662
55	SOX2_20726797_ChIP-Seq_SW620_Human	0.85890993
56	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85107021
57	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.84919903
58	TAF2_19829295_ChIP-Seq_ESCs_Human	0.83771808
59	LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.83224438
60	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.82648958
61	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.82423178
62	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.80171236
63	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.79843907
64	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.79282324
65	CEBPB_22108803_ChIP-Seq_LS180_Human	0.79107620
66	CDX2_22108803_ChIP-Seq_LS180_Human	0.78963949
67	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.78721211
68	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.77905178
69	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.77871550
70	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.77026361
71	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.76730763
72	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.75264006
73	EZH2_22144423_ChIP-Seq_EOC_Human	0.74925573
74	SOX2_21211035_ChIP-Seq_LN229_Human	0.73069994
75	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.72845065
76	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.71209027
77	CBP_21632823_ChIP-Seq_H3396_Human	0.69940150
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.69285237
79	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.69153193
80	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.68802745
81	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.68581499
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.68459013
83	GATA1_22025678_ChIP-Seq_K562_Human	0.68319762
84	CJUN_26792858_Chip-Seq_BT549_Human	0.67632262
85	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.67444093
86	OCT4_20526341_ChIP-Seq_ESCs_Human	0.66353147
87	TAF15_26573619_Chip-Seq_HEK293_Human	0.66108003
88	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.66056748
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.64796284
90	BCAT_22108803_ChIP-Seq_LS180_Human	0.64194046
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.63551745
92	REST_21632747_ChIP-Seq_MESCs_Mouse	0.62351842
93	AR_20517297_ChIP-Seq_VCAP_Human	0.61358686
94	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.61110302
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.60522754
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.60522754
97	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.60209681
98	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.59699762
99	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.59528597
100	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.59509873

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003868_abnormal_feces_composition	9.21047799
2	MP0005365_abnormal_bile_salt	7.33608076
3	MP0005083_abnormal_biliary_tract	4.33940342
4	MP0005220_abnormal_exocrine_pancreas	3.85843707
5	MP0003959_abnormal_lean_body	2.64095651
6	MP0005084_abnormal_gallbladder_morpholo	2.60990076
7	MP0005085_abnormal_gallbladder_physiolo	2.60101428
8	MP0003011_delayed_dark_adaptation	2.38811282
9	MP0008004_abnormal_stomach_pH	2.27544428
10	MP0001666_abnormal_nutrient_absorption	12.6907809
11	MP0002693_abnormal_pancreas_physiology	1.94094752
12	MP0002138_abnormal_hepatobiliary_system	1.79377092
13	MP0010329_abnormal_lipoprotein_level	1.69062052
14	MP0002118_abnormal_lipid_homeostasis	1.60493098
15	MP0003252_abnormal_bile_duct	1.57341056
16	MP0005448_abnormal_energy_balance	1.57246062
17	MP0010386_abnormal_urinary_bladder	1.40316072
18	MP0010368_abnormal_lymphatic_system	1.32219254
19	MP0003950_abnormal_plasma_membrane	1.30883174
20	MP0001501_abnormal_sleep_pattern	1.28767822
21	MP0002928_abnormal_bile_duct	1.26862254
22	MP0000613_abnormal_salivary_gland	1.20351950
23	MP0005452_abnormal_adipose_tissue	1.17847235
24	MP0003045_fibrosis	1.14291714
25	MP0001502_abnormal_circadian_rhythm	1.08743431
26	MP0003941_abnormal_skin_development	1.01201938
27	MP0005334_abnormal_fat_pad	0.99776641
28	MP0004264_abnormal_extraembryonic_tissu	0.95955721
29	MP0003943_abnormal_hepatobiliary_system	0.94974146
30	MP0001944_abnormal_pancreas_morphology	0.94116663
31	MP0003195_calcinosis	0.89711457
32	MP0003953_abnormal_hormone_level	0.88769503
33	MP0002078_abnormal_glucose_homeostasis	0.87827700
34	MP0000566_synostosis	0.86128708
35	MP0002970_abnormal_white_adipose	0.85070087
36	MP0001873_stomach_inflammation	0.83620761
37	MP0001664_abnormal_digestion	0.80363302
38	MP0002132_abnormal_respiratory_system	0.78860732
39	MP0002876_abnormal_thyroid_physiology	0.73249878
40	MP0003300_gastrointestinal_ulcer	0.71812045
41	MP0003828_pulmonary_edema	0.70672800
42	MP0000598_abnormal_liver_morphology	0.70327446
43	MP0000470_abnormal_stomach_morphology	0.63831534
44	MP0002102_abnormal_ear_morphology	0.63196132
45	MP0008995_early_reproductive_senescence	0.62862280
46	MP0002089_abnormal_postnatal_growth/wei	0.61786338
47	MP0001845_abnormal_inflammatory_respons	0.58738892
48	MP0001485_abnormal_pinna_reflex	0.58575680
49	MP0004043_abnormal_pH_regulation	0.58338415
50	MP0000462_abnormal_digestive_system	0.56427017
51	MP0001731_abnormal_postnatal_growth	0.55008578
52	MP0004233_abnormal_muscle_weight	0.52442812
53	MP0008770_decreased_survivor_rate	0.51866461
54	MP0005646_abnormal_pituitary_gland	0.49591901
55	MP0009384_cardiac_valve_regurgitation	0.49192061
56	MP0002163_abnormal_gland_morphology	0.46259878
57	MP0005332_abnormal_amino_acid	0.44724873
58	MP0001879_abnormal_lymphatic_vessel	0.41280821
59	MP0001984_abnormal_olfaction	0.40324557
60	MP0000367_abnormal_coat/_hair	0.40080739
61	MP0006138_congestive_heart_failure	0.39019544
62	MP0005166_decreased_susceptibility_to	0.35844981
63	MP0002653_abnormal_ependyma_morphology	0.35309379
64	MP0003638_abnormal_response/metabolism_	0.35215006
65	MP0009642_abnormal_blood_homeostasis	0.33560206
66	MP0002277_abnormal_respiratory_mucosa	0.32494491
67	MP0008872_abnormal_physiological_respon	0.30669407
68	MP0002938_white_spotting	0.30648879
69	MP0008961_abnormal_basal_metabolism	0.29299281
70	MP0003879_abnormal_hair_cell	0.28827827
71	MP0002168_other_aberrant_phenotype	0.26095083
72	MP0000609_abnormal_liver_physiology	0.26076522
73	MP0002405_respiratory_system_inflammati	0.25311604
74	MP0002009_preneoplasia	0.24319096
75	MP0004019_abnormal_vitamin_homeostasis	0.24119860
76	MP0002069_abnormal_eating/drinking_beha	0.23967372
77	MP0001986_abnormal_taste_sensitivity	0.22967914
78	MP0005319_abnormal_enzyme/_coenzyme	0.22917218
79	MP0009780_abnormal_chondrocyte_physiolo	0.22173864
80	MP0001790_abnormal_immune_system	0.21853260
81	MP0005387_immune_system_phenotype	0.21853260
82	MP0000750_abnormal_muscle_regeneration	0.21607706
83	MP0000432_abnormal_head_morphology	0.20780778
84	MP0001851_eye_inflammation	0.20634891
85	MP0009643_abnormal_urine_homeostasis	0.20533172
86	MP0003866_abnormal_defecation	0.19449880
87	MP0003956_abnormal_body_size	0.18893678
88	MP0005076_abnormal_cell_differentiation	0.18855320
89	MP0004145_abnormal_muscle_electrophysio	0.18146183
90	MP0009763_increased_sensitivity_to	0.17465262
91	MP0005410_abnormal_fertilization	0.16942790
92	MP0004085_abnormal_heartbeat	0.16543739
93	MP0003436_decreased_susceptibility_to	0.16508318
94	MP0001784_abnormal_fluid_regulation	0.15743437
95	MP0005551_abnormal_eye_electrophysiolog	0.15091446
96	MP0002736_abnormal_nociception_after	0.14933923
97	MP0002796_impaired_skin_barrier	0.14341374
98	MP0002139_abnormal_hepatobiliary_system	0.13654865
99	MP0001756_abnormal_urination	0.13548911
100	MP0002127_abnormal_cardiovascular_syste	0.13158319

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatitis (HP:0001733)	5.69719339
2	Genetic anticipation (HP:0003743)	5.44615127
3	Abnormality of the pleura (HP:0002103)	4.17071341
4	Progressive cerebellar ataxia (HP:0002073)	3.79821417
5	Abnormal pancreas size (HP:0012094)	3.69705711
6	Abnormality of the hepatic vasculature (HP:0006707)	3.30851308
7	Large for gestational age (HP:0001520)	2.77324378
8	Portal hypertension (HP:0001409)	2.66317101
9	Generalized aminoaciduria (HP:0002909)	2.56468517
10	Congenital sensorineural hearing impairment (HP:0008527)	2.53684229
11	Slow saccadic eye movements (HP:0000514)	2.51710222
12	Anal atresia (HP:0002023)	2.50873622
13	Barrel-shaped chest (HP:0001552)	2.35607795
14	Dysmetric saccades (HP:0000641)	2.32971083
15	Abnormality of the nasal septum (HP:0000419)	2.29276315
16	Tubulointerstitial nephritis (HP:0001970)	2.26766602
17	Azoospermia (HP:0000027)	2.26463619
18	Glycosuria (HP:0003076)	2.25630728
19	Abnormality of urine glucose concentration (HP:0011016)	2.25630728
20	Type I transferrin isoform profile (HP:0003642)	2.20359312
21	Abnormality of the aortic arch (HP:0012303)	2.19757204
22	Hypothermia (HP:0002045)	2.18169651
23	Ileus (HP:0002595)	2.17151245
24	Hepatocellular necrosis (HP:0001404)	2.15153155
25	Popliteal pterygium (HP:0009756)	2.12717321
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.11968779
27	Absent/shortened dynein arms (HP:0200106)	2.11968779
28	Tubular atrophy (HP:0000092)	2.06211555
29	Steatorrhea (HP:0002570)	17.6884823
30	Fat malabsorption (HP:0002630)	13.7083714
31	Hypoproteinemia (HP:0003075)	12.1909739
32	Exocrine pancreatic insufficiency (HP:0001738)	10.8520084
33	Abnormality of the pons (HP:0007361)	1.98245344
34	Ventricular fibrillation (HP:0001663)	1.97771345
35	Periauricular skin pits (HP:0100277)	1.97687833
36	Preauricular pit (HP:0004467)	1.97687833
37	Abnormality of methionine metabolism (HP:0010901)	1.97217153
38	Axonal loss (HP:0003447)	1.90190786
39	Chronic hepatic failure (HP:0100626)	1.89088703
40	Depressed nasal tip (HP:0000437)	1.86525346
41	Abnormal protein glycosylation (HP:0012346)	1.82840674
42	Abnormal glycosylation (HP:0012345)	1.82840674
43	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.82840674
44	Abnormal protein N-linked glycosylation (HP:0012347)	1.82840674
45	Aplastic anemia (HP:0001915)	1.82701223
46	Duplicated collecting system (HP:0000081)	1.82277865
47	Congenital malformation of the right heart (HP:0011723)	1.81066994
48	Double outlet right ventricle (HP:0001719)	1.81066994
49	Cerebellar dysplasia (HP:0007033)	1.80737587
50	Decreased circulating renin level (HP:0003351)	1.78399033
51	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.77660793
52	Absent eyebrow (HP:0002223)	1.75113568
53	Vascular calcification (HP:0004934)	1.74818229
54	Gaze-evoked nystagmus (HP:0000640)	1.74644691
55	Action tremor (HP:0002345)	1.74242668
56	Prostate neoplasm (HP:0100787)	1.71811266
57	Autoimmune thrombocytopenia (HP:0001973)	1.71293890
58	Transposition of the great arteries (HP:0001669)	1.70940496
59	Abnormal connection of the cardiac segments (HP:0011545)	1.70940496
60	Abnormal ventriculo-arterial connection (HP:0011563)	1.70940496
61	Facial shape deformation (HP:0011334)	1.70862488
62	Potter facies (HP:0002009)	1.70862488
63	Abnormality of the renal collecting system (HP:0004742)	1.70151503
64	Hepatic necrosis (HP:0002605)	1.69049430
65	Malnutrition (HP:0004395)	1.67316549
66	Tubulointerstitial abnormality (HP:0001969)	1.67315012
67	Esophageal varix (HP:0002040)	1.67235402
68	Male infertility (HP:0003251)	1.66882199
69	Pigmentary retinal degeneration (HP:0001146)	1.65239570
70	Abdominal pain (HP:0002027)	1.61402498
71	Optic nerve hypoplasia (HP:0000609)	1.59289450
72	Type II lissencephaly (HP:0007260)	1.58681210
73	Skin pits (HP:0100276)	1.58320780
74	Focal seizures (HP:0007359)	1.57811031
75	Type I diabetes mellitus (HP:0100651)	1.57390458
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.54326282
77	Urinary bladder sphincter dysfunction (HP:0002839)	1.52825749
78	Tubulointerstitial fibrosis (HP:0005576)	1.51783677
79	Cardiovascular calcification (HP:0011915)	1.49161589
80	Right ventricular cardiomyopathy (HP:0011663)	1.47849165
81	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.47192872
82	Nonimmune hydrops fetalis (HP:0001790)	1.46600065
83	Abnormal spermatogenesis (HP:0008669)	1.44031034
84	Multiple enchondromatosis (HP:0005701)	1.42314904
85	Prolonged partial thromboplastin time (HP:0003645)	1.38011515
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.37561775
87	3-Methylglutaconic aciduria (HP:0003535)	1.35054649
88	Severe visual impairment (HP:0001141)	1.34695345
89	Oral leukoplakia (HP:0002745)	1.31725333
90	Abnormality of homocysteine metabolism (HP:0010919)	1.31348746
91	Homocystinuria (HP:0002156)	1.31348746
92	Gonadal dysgenesis (HP:0000133)	1.31070527
93	Abnormality of the renal medulla (HP:0100957)	1.30992079
94	Hypoplastic left heart (HP:0004383)	1.30853742
95	Hypoplasia of the odontoid process (HP:0003311)	1.30467999
96	Syncope (HP:0001279)	1.28701097
97	Ureteral duplication (HP:0000073)	1.28457416
98	Enlarged kidneys (HP:0000105)	1.28284504
99	Increased CSF protein (HP:0002922)	1.26440373
100	Gowers sign (HP:0003391)	1.26267869

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	7.59488754
2	LMTK2	4.88120068
3	EIF2AK3	3.83710239
4	MAPK15	3.31405987
5	EPHA2	3.29570254
6	NME1	3.14876647
7	CDK19	2.72137165
8	MAP3K3	2.67395108
9	GRK1	2.61925984
10	PDK2	2.53837544
11	ERN1	2.34731167
12	OXSR1	2.21020122
13	MAP3K2	2.19357888
14	INSRR	2.13151044
15	MAP3K7	2.11339649
16	IRAK1	2.05540198
17	FRK	2.01158093
18	STK39	1.97950649
19	TIE1	1.97884635
20	KDR	1.79294723
21	ICK	1.72022718
22	WNK4	1.59577904
23	IRAK2	1.47959686
24	RIPK1	1.41062228
25	NTRK3	1.26686454
26	MAP3K5	1.09922550
27	MAP3K12	0.97635580
28	STK38	0.88061812
29	CASK	0.83054317
30	ZAP70	0.82692516
31	NLK	0.79551968
32	SGK2	0.73530682
33	LRRK2	0.73207686
34	TAF1	0.72272987
35	PASK	0.72227157
36	BMPR1B	0.72130146
37	SGK3	0.70745359
38	IKBKE	0.69726037
39	PRKG2	0.69716931
40	MAPKAPK3	0.68606833
41	MELK	0.66956943
42	STK11	0.66813860
43	PIM1	0.63240274
44	MUSK	0.62529232
45	TESK1	0.62115948
46	WNK1	0.60084380
47	PRKCQ	0.56320956
48	MAPK7	0.56191531
49	MARK3	0.54935560
50	SGK494	0.52696121
51	SGK223	0.52696121
52	PRKAA2	0.49596637
53	MST1R	0.49274663
54	MAP4K1	0.47262040
55	MAP3K13	0.47048417
56	PIM2	0.46909539
57	CSNK1A1	0.45331812
58	TNIK	0.43640170
59	PDK1	0.43042287
60	CHUK	0.41661076
61	PDPK1	0.41308325
62	MARK1	0.39150002
63	MAP3K11	0.37555422
64	GRK5	0.37001444
65	CDK8	0.36474245
66	TBK1	0.35246317
67	MAPK1	0.35195233
68	NEK6	0.35020037
69	MAP2K2	0.34950585
70	MAPKAPK5	0.34401768
71	RPS6KB2	0.32067507
72	TEC	0.30469496
73	STK24	0.29962516
74	MAPK3	0.29920884
75	HIPK2	0.28928016
76	CSNK1G1	0.28180826
77	CAMKK1	0.28021450
78	FER	0.27971842
79	CAMK4	0.27744199
80	ADRBK2	0.27555859
81	PRKAA1	0.27094033
82	TNK2	0.25482596
83	KSR1	0.24663949
84	IKBKB	0.24404162
85	BRSK2	0.23132165
86	ADRBK1	0.22975505
87	RPS6KB1	0.22955632
88	PRKACA	0.22857601
89	CSNK1A1L	0.22741951
90	CSNK1D	0.22604001
91	BRD4	0.21711807
92	BLK	0.21407782
93	SGK1	0.21143318
94	PRKCZ	0.20375577
95	MTOR	0.19429736
96	STK16	0.19044627
97	ALK	0.18967488
98	PIK3CG	0.18456977
99	PRKCI	0.18397438
100	RPS6KA3	0.18378897

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pancreatic secretion_Homo sapiens_hsa04972	9.78023593
2	Fat digestion and absorption_Homo sapiens_hsa04975	8.36916935
3	Protein digestion and absorption_Homo sapiens_hsa04974	6.31291170
4	Glycerolipid metabolism_Homo sapiens_hsa00561	3.13977991
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.13743667
6	Renin-angiotensin system_Homo sapiens_hsa04614	2.80479546
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53818712
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.26443996
9	Steroid biosynthesis_Homo sapiens_hsa00100	1.73345290
10	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.61375269
11	Ether lipid metabolism_Homo sapiens_hsa00565	1.61261465
12	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.45201963
13	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.44446201
14	Notch signaling pathway_Homo sapiens_hsa04330	1.41064343
15	Circadian rhythm_Homo sapiens_hsa04710	1.29196986
16	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.01573381
17	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.82796391
18	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.73616529
19	Influenza A_Homo sapiens_hsa05164	0.70589763
20	Phototransduction_Homo sapiens_hsa04744	0.67036946
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.61431998
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.60155451
23	Mineral absorption_Homo sapiens_hsa04978	0.54370462
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.50659860
25	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45220290
26	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.44565754
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.43011739
28	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41723271
29	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.41682305
30	Glutathione metabolism_Homo sapiens_hsa00480	0.38594636
31	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.35853131
32	Bile secretion_Homo sapiens_hsa04976	0.34846917
33	Protein export_Homo sapiens_hsa03060	0.32569374
34	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.32169419
35	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.31446766
36	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28787945
37	Retinol metabolism_Homo sapiens_hsa00830	0.26467365
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.25986249
39	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.25951193
40	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22010700
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.21721993
42	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.21398065
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.20069871
44	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.19472624
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.19277811
46	Complement and coagulation cascades_Homo sapiens_hsa04610	0.17384392
47	Ras signaling pathway_Homo sapiens_hsa04014	0.16167621
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.15964083
49	ABC transporters_Homo sapiens_hsa02010	0.15875112
50	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.11337177
51	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.11184418
52	Adherens junction_Homo sapiens_hsa04520	0.10040870
53	Metabolic pathways_Homo sapiens_hsa01100	0.09306200
54	Viral carcinogenesis_Homo sapiens_hsa05203	0.08926993
55	Hepatitis C_Homo sapiens_hsa05160	0.08510407
56	Propanoate metabolism_Homo sapiens_hsa00640	0.06966640
57	Pertussis_Homo sapiens_hsa05133	0.05293204
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.05222079
59	Tight junction_Homo sapiens_hsa04530	0.05127824
60	Sulfur metabolism_Homo sapiens_hsa00920	0.03378533
61	Fatty acid degradation_Homo sapiens_hsa00071	0.03367353
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.03261482
63	Legionellosis_Homo sapiens_hsa05134	0.02910899
64	Insulin secretion_Homo sapiens_hsa04911	0.02598390
65	FoxO signaling pathway_Homo sapiens_hsa04068	0.02490166
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.01430524
67	Ribosome_Homo sapiens_hsa03010	0.00101460
68	Serotonergic synapse_Homo sapiens_hsa04726	-0.1217232
69	Renin secretion_Homo sapiens_hsa04924	-0.1143376
70	Insulin resistance_Homo sapiens_hsa04931	-0.1136595
71	Vibrio cholerae infection_Homo sapiens_hsa05110	-0.1053657
72	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.1028099
73	Glutamatergic synapse_Homo sapiens_hsa04724	-0.1017808
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	-0.0954948
75	Axon guidance_Homo sapiens_hsa04360	-0.0950119
76	Parkinsons disease_Homo sapiens_hsa05012	-0.0919723
77	Taste transduction_Homo sapiens_hsa04742	-0.0882931
78	PPAR signaling pathway_Homo sapiens_hsa03320	-0.0837318
79	ErbB signaling pathway_Homo sapiens_hsa04012	-0.0810907
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	-0.0791043
81	Hippo signaling pathway_Homo sapiens_hsa04390	-0.0773752
82	Butanoate metabolism_Homo sapiens_hsa00650	-0.0772917
83	Hematopoietic cell lineage_Homo sapiens_hsa04640	-0.0694636
84	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	-0.0648874
85	Peroxisome_Homo sapiens_hsa04146	-0.0648136
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	-0.0647022
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	-0.0610375
88	One carbon pool by folate_Homo sapiens_hsa00670	-0.0563141
89	Selenocompound metabolism_Homo sapiens_hsa00450	-0.0406932
90	Sphingolipid metabolism_Homo sapiens_hsa00600	-0.0393345
91	Melanoma_Homo sapiens_hsa05218	-0.0367585
92	Olfactory transduction_Homo sapiens_hsa04740	-0.0359112
93	Herpes simplex infection_Homo sapiens_hsa05168	-0.0315448
94	beta-Alanine metabolism_Homo sapiens_hsa00410	-0.0296608
95	Histidine metabolism_Homo sapiens_hsa00340	-0.0257991
96	TNF signaling pathway_Homo sapiens_hsa04668	-0.0206446
97	Fatty acid biosynthesis_Homo sapiens_hsa00061	-0.0132075
98	MAPK signaling pathway_Homo sapiens_hsa04010	-0.0101621
99	TGF-beta signaling pathway_Homo sapiens_hsa04350	-0.0041908
100	Alzheimers disease_Homo sapiens_hsa05010	-0.0003214

REG1CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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