REG3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)8.82998710
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)8.32102750
3transcytosis (GO:0045056)7.50124196
4regulation of guanylate cyclase activity (GO:0031282)7.49277325
5regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.28105115
6regulation of cellular extravasation (GO:0002691)7.05149310
7positive regulation of guanylate cyclase activity (GO:0031284)5.81086659
8cholesterol catabolic process (GO:0006707)5.63954230
9sterol catabolic process (GO:0016127)5.63954230
10negative regulation of digestive system process (GO:0060457)5.58152265
11fructose metabolic process (GO:0006000)5.25493580
12epoxygenase P450 pathway (GO:0019373)5.17949955
13cysteine metabolic process (GO:0006534)5.16973554
14lipoprotein transport (GO:0042953)5.16344582
15peptidyl-proline hydroxylation (GO:0019511)5.15820474
16regulation of bile acid biosynthetic process (GO:0070857)5.12247524
17fat-soluble vitamin biosynthetic process (GO:0042362)5.10391332
18positive regulation of pseudopodium assembly (GO:0031274)5.05836072
19cobalamin metabolic process (GO:0009235)5.00627692
20Golgi transport vesicle coating (GO:0048200)4.99294037
21COPI coating of Golgi vesicle (GO:0048205)4.99294037
22hormone catabolic process (GO:0042447)4.70160842
23regulation of systemic arterial blood pressure by hormone (GO:0001990)4.70143619
24regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.70143619
25endocrine process (GO:0050886)4.70143619
26digestive system process (GO:0022600)4.60687780
27regulation of cGMP biosynthetic process (GO:0030826)4.56780789
28regulation of pseudopodium assembly (GO:0031272)4.54623885
29positive regulation of respiratory burst (GO:0060267)4.54060465
30maintenance of gastrointestinal epithelium (GO:0030277)4.53816951
31intestinal epithelial cell development (GO:0060576)4.49645113
32membrane lipid catabolic process (GO:0046466)4.48344162
33diacylglycerol metabolic process (GO:0046339)4.38091409
34regulation of systemic arterial blood pressure (GO:0003073)4.33409207
35regulation of autophagic vacuole assembly (GO:2000785)4.31911037
36positive regulation of glycoprotein biosynthetic process (GO:0010560)4.31668039
37proline biosynthetic process (GO:0006561)4.29905013
38glycolipid catabolic process (GO:0019377)4.28838400
39virion attachment to host cell (GO:0019062)4.24284749
40adhesion of symbiont to host cell (GO:0044650)4.24284749
41receptor guanylyl cyclase signaling pathway (GO:0007168)4.18375928
42sterol transport (GO:0015918)4.18053460
43cholesterol transport (GO:0030301)4.18053460
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.13354170
45zinc ion transport (GO:0006829)4.11868671
46endocrine pancreas development (GO:0031018)4.08387306
47angiotensin maturation (GO:0002003)4.06530994
48regulation of phospholipase A2 activity (GO:0032429)4.05198237
49cellular modified amino acid catabolic process (GO:0042219)4.04887991
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03332894
51urea cycle (GO:0000050)4.01968064
52ceramide catabolic process (GO:0046514)4.01180495
53very-low-density lipoprotein particle assembly (GO:0034379)3.98890015
54regulation of vitamin metabolic process (GO:0030656)3.97906618
55homocysteine metabolic process (GO:0050667)3.97302517
56signal peptide processing (GO:0006465)3.95439301
57activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO3.93881024
58positive regulation of nuclease activity (GO:0032075)3.92822659
59positive regulation of glycoprotein metabolic process (GO:1903020)3.92082914
60protein maturation by protein folding (GO:0022417)3.90953184
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.87896041
62drug metabolic process (GO:0017144)3.85174962
63protein hydroxylation (GO:0018126)3.81738563
64urea metabolic process (GO:0019627)3.80105270
65regulation of cGMP metabolic process (GO:0030823)3.77899306
66antigen processing and presentation of endogenous antigen (GO:0019883)3.77149154
67mitochondrial calcium ion transport (GO:0006851)3.77049404
68response to endoplasmic reticulum stress (GO:0034976)3.72272377
69COPII vesicle coating (GO:0048208)3.72212566
70regulation of dendritic cell antigen processing and presentation (GO:0002604)3.72167519
71L-alpha-amino acid transmembrane transport (GO:1902475)3.66373656
72endoplasmic reticulum unfolded protein response (GO:0030968)3.65520298
734-hydroxyproline metabolic process (GO:0019471)3.63437467
74purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.60931717
753-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.60931717
76glycosphingolipid catabolic process (GO:0046479)3.60328737
77regulation of triglyceride catabolic process (GO:0010896)3.58328769
78response to nitric oxide (GO:0071731)3.55490888
79peptide catabolic process (GO:0043171)3.54677980
80regulation of nuclease activity (GO:0032069)3.54387312
81adhesion of symbiont to host (GO:0044406)3.54305440
82vitamin A metabolic process (GO:0006776)3.53988334
83nitrogen cycle metabolic process (GO:0071941)3.53099601
84cellular response to unfolded protein (GO:0034620)3.52784865
85uronic acid metabolic process (GO:0006063)3.52074197
86glucuronate metabolic process (GO:0019585)3.52074197
87renal system process involved in regulation of blood volume (GO:0001977)3.51359482
88cellular glucuronidation (GO:0052695)3.49422653
89glomerular filtration (GO:0003094)3.48256578
90complement activation, classical pathway (GO:0006958)3.46795864
91arginine metabolic process (GO:0006525)3.46138612
92plasma lipoprotein particle assembly (GO:0034377)3.42864528
93antibacterial humoral response (GO:0019731)3.41520667
94valine metabolic process (GO:0006573)3.40758324
95bile acid and bile salt transport (GO:0015721)3.39706574
96positive regulation of cGMP biosynthetic process (GO:0030828)3.37747797
97cellular response to nitric oxide (GO:0071732)3.36065140
98ER-nucleus signaling pathway (GO:0006984)3.35089025
99cellular response to topologically incorrect protein (GO:0035967)3.31710340
100antimicrobial humoral response (GO:0019730)3.28910514
101epithelial structure maintenance (GO:0010669)3.28472422
102regulation of vacuole organization (GO:0044088)3.26221766
103leukotriene biosynthetic process (GO:0019370)3.24514081
104leukotriene metabolic process (GO:0006691)3.24341301
105calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.23412054
106eosinophil chemotaxis (GO:0048245)3.21158355
107vitamin transmembrane transport (GO:0035461)3.19885031
108coenzyme catabolic process (GO:0009109)3.19355401
109nucleoside diphosphate biosynthetic process (GO:0009133)3.18445976
110renal filtration (GO:0097205)3.15095931
111branched-chain amino acid catabolic process (GO:0009083)3.14436411
112pyrimidine ribonucleoside catabolic process (GO:0046133)3.13931352
113GDP-mannose metabolic process (GO:0019673)3.13198801
114protein-lipid complex assembly (GO:0065005)3.12765916
115vitamin transport (GO:0051180)3.12688407
116phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.08619551
117serine family amino acid biosynthetic process (GO:0009070)3.07739997
118regulation of respiratory burst (GO:0060263)3.07251875
119lipoprotein metabolic process (GO:0042157)3.07048099
120positive regulation of Cdc42 GTPase activity (GO:0043089)3.06225611
121UDP-N-acetylglucosamine metabolic process (GO:0006047)3.05301733
122glutamine family amino acid biosynthetic process (GO:0009084)3.02057719
123cGMP-mediated signaling (GO:0019934)3.02027370
124phosphatidylinositol acyl-chain remodeling (GO:0036149)3.00894134
125low-density lipoprotein particle remodeling (GO:0034374)3.00867236
126killing of cells of other organism (GO:0031640)2.99625476
127disruption of cells of other organism (GO:0044364)2.99625476
128cellular response to reactive nitrogen species (GO:1902170)2.98175408
129retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.98022439
130sphingolipid catabolic process (GO:0030149)2.97982620
131cellular response to cadmium ion (GO:0071276)2.97156812
132sulfur amino acid catabolic process (GO:0000098)2.96444707
133steroid catabolic process (GO:0006706)2.95901431
134sexual reproduction (GO:0019953)2.94272732
135peptide hormone processing (GO:0016486)2.93663828
136phosphatidylcholine acyl-chain remodeling (GO:0036151)2.92471320
137maintenance of protein localization in organelle (GO:0072595)2.92448763
138positive regulation of cGMP metabolic process (GO:0030825)2.92166788
139regulation of digestive system process (GO:0044058)2.91898235
140negative regulation of keratinocyte proliferation (GO:0010839)2.90457255
141response to unfolded protein (GO:0006986)2.90078148
142ethanol oxidation (GO:0006069)2.90024536
143regulation of cholesterol homeostasis (GO:2000188)2.88996032
144NADH metabolic process (GO:0006734)2.88689746
145phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.86856878
146positive regulation of antigen processing and presentation (GO:0002579)2.86782812
147ER overload response (GO:0006983)2.86136114
148midgut development (GO:0007494)2.85696015
149branched-chain amino acid metabolic process (GO:0009081)2.84733723
150proline metabolic process (GO:0006560)2.82731420
151ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.81921177
152protein N-linked glycosylation via asparagine (GO:0018279)2.79428516
153regulation of fever generation (GO:0031620)2.78693389
154response to topologically incorrect protein (GO:0035966)2.77718563
155glandular epithelial cell differentiation (GO:0002067)2.77159692
156peptidyl-asparagine modification (GO:0018196)2.77073543
157mucosal immune response (GO:0002385)2.76850214
158glucose 6-phosphate metabolic process (GO:0051156)2.75461823
159positive regulation of heat generation (GO:0031652)2.74939753
160creatine metabolic process (GO:0006600)2.72557708
161alkaloid metabolic process (GO:0009820)2.70578967
162innate immune response in mucosa (GO:0002227)2.68781277
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.68353681
164sulfation (GO:0051923)2.68184124
165aspartate family amino acid catabolic process (GO:0009068)2.65507587
166erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.64815462
167L-phenylalanine catabolic process (GO:0006559)2.64815462
168cytidine deamination (GO:0009972)2.64633018
169cytidine metabolic process (GO:0046087)2.64633018
170cytidine catabolic process (GO:0006216)2.64633018
171triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.61793925
172glutamine metabolic process (GO:0006541)2.61221565
173negative regulation of macroautophagy (GO:0016242)2.60944655
174organ or tissue specific immune response (GO:0002251)2.60687434
175membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.59825879
176intestinal cholesterol absorption (GO:0030299)19.4124869
177digestion (GO:0007586)11.8381875
178intestinal absorption (GO:0050892)11.2594529
179exocrine pancreas development (GO:0031017)10.7173710

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.20112408
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.06799611
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.58446708
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.48239956
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.39105896
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.38300041
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20729110
8PPARA_22158963_ChIP-Seq_LIVER_Mouse3.13524831
9CDX2_20551321_ChIP-Seq_CACO-2_Human3.12531142
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.00524057
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.90643156
12* GATA4_25053715_ChIP-Seq_YYC3_Human2.84167082
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.63568196
14* GATA6_25053715_ChIP-Seq_YYC3_Human2.47807715
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.44745882
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.38642844
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.38504682
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.29103379
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.24453130
20SOX2_20726797_ChIP-Seq_SW620_Human2.19880221
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.18469829
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.18222448
23GATA1_22025678_ChIP-Seq_K562_Human2.06588641
24PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.91735620
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.79344197
26ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76482876
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.70835398
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.68927317
29PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.68630323
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67151983
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56827685
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.56766865
33FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.56378964
34CLOCK_20551151_ChIP-Seq_293T_Human1.52742892
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51379726
36PPAR_26484153_Chip-Seq_NCI-H1993_Human1.45388500
37CREB1_26743006_Chip-Seq_LNCaP_Human1.44018103
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.43775010
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43168568
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41861093
41ATF3_27146783_Chip-Seq_COLON_Human1.41625801
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.41414431
43CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40739668
44KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38947631
45AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.36658264
46EGR1_19032775_ChIP-ChIP_M12_Human1.35178613
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.34614742
48RACK7_27058665_Chip-Seq_MCF-7_Human1.33363886
49LXR_22292898_ChIP-Seq_THP-1_Human1.32791258
50* FOXA1_25552417_ChIP-Seq_VCAP_Human1.32115154
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.30665209
52NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30072812
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27386523
54KLF5_25053715_ChIP-Seq_YYC3_Human1.26973497
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.25215763
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22130124
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.20798465
58BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19032384
59TP63_22573176_ChIP-Seq_HFKS_Human1.18426269
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18285828
61SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16267957
62CTCF_27219007_Chip-Seq_Bcells_Human1.15778957
63* TCF4_18268006_ChIP-ChIP_LS174T_Human1.15374313
64PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13623486
65P68_20966046_ChIP-Seq_HELA_Human1.13550046
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13506171
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.13176658
68BCL6_27268052_Chip-Seq_Bcells_Human1.12234032
69ERG_20517297_ChIP-Seq_VCAP_Human1.12038335
70GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.11041907
71BCOR_27268052_Chip-Seq_Bcells_Human1.10200173
72TET1_21451524_ChIP-Seq_MESCs_Mouse1.09834967
73FOXH1_21741376_ChIP-Seq_ESCs_Human1.09298685
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08030468
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06452410
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06122735
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05922367
78SA1_27219007_Chip-Seq_ERYTHROID_Human1.05445185
79* TAF2_19829295_ChIP-Seq_ESCs_Human1.04100717
80GATA3_24758297_ChIP-Seq_MCF-7_Human1.03793916
81STAT1_20625510_ChIP-Seq_HELA_Human1.02515105
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02496036
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01978538
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01317016
85SA1_27219007_Chip-Seq_Bcells_Human0.99422007
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98380010
87SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98226353
88ESET_19884257_ChIP-Seq_ESCs_Mouse0.97371872
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97078656
90HNF4A_19822575_ChIP-Seq_HepG2_Human0.95798230
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95553340
92CDX2_22108803_ChIP-Seq_LS180_Human0.95280892
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94377371
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91892487
95RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91587157
96NANOG_20526341_ChIP-Seq_ESCs_Human0.91454258
97VDR_24763502_ChIP-Seq_THP-1_Human0.90799424
98CHD1_26751641_Chip-Seq_LNCaP_Human0.90324917
99GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90318139
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.89786974
101GATA1_19941826_ChIP-Seq_K562_Human0.89121141
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88894588
103IRF8_27001747_Chip-Seq_BMDM_Mouse0.88771615
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88516476
105JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.87980586
106RXR_22108803_ChIP-Seq_LS180_Human0.87839701
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87562606
108ETS1_21867929_ChIP-Seq_TH2_Mouse0.86463676
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86098400
110NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85889197
111CTCF_20526341_ChIP-Seq_ESCs_Human0.85550188
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85377230
113EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85355818
114MYC_19915707_ChIP-ChIP_AK7_Human0.84882089
115VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84308231
116FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84191286
117RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83930352
118GATA2_19941826_ChIP-Seq_K562_Human0.83921442
119TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83729162
120CEBPB_22108803_ChIP-Seq_LS180_Human0.83606962
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83014447
122OCT4_20526341_ChIP-Seq_ESCs_Human0.82572651
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82468031
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81138847
125KLF4_19829295_ChIP-Seq_ESCs_Human0.78756575
126KDM2B_26808549_Chip-Seq_K562_Human0.78340767
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.77688380
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.77678819
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77449619
130P300_27268052_Chip-Seq_Bcells_Human0.76440356
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75986877
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.75879691
133ERA_21632823_ChIP-Seq_H3396_Human0.73882891
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73755411
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.73331089
136PHF8_20622854_ChIP-Seq_HELA_Human0.73018768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption9.57260918
2MP0005083_abnormal_biliary_tract5.93010491
3MP0005365_abnormal_bile_salt5.86293873
4MP0003868_abnormal_feces_composition4.98815713
5MP0005220_abnormal_exocrine_pancreas4.29005404
6MP0010234_abnormal_vibrissa_follicle4.02628527
7MP0005085_abnormal_gallbladder_physiolo3.80369143
8MP0009379_abnormal_foot_pigmentation3.68587623
9MP0005360_urolithiasis3.68467168
10MP0005084_abnormal_gallbladder_morpholo3.62325442
11MP0003283_abnormal_digestive_organ2.93482107
12MP0004264_abnormal_extraembryonic_tissu2.76936906
13MP0002139_abnormal_hepatobiliary_system2.65184574
14MP0002693_abnormal_pancreas_physiology2.54798938
15MP0004147_increased_porphyrin_level2.50915899
16MP0003959_abnormal_lean_body2.23734291
17MP0001664_abnormal_digestion2.22956426
18MP0003252_abnormal_bile_duct2.06111167
19MP0005448_abnormal_energy_balance2.03806019
20MP0003705_abnormal_hypodermis_morpholog2.02824769
21MP0005409_darkened_coat_color1.93974249
22MP0003183_abnormal_peptide_metabolism1.89309560
23MP0004858_abnormal_nervous_system1.85444613
24MP0005166_decreased_susceptibility_to1.80904426
25MP0001944_abnormal_pancreas_morphology1.69154742
26MP0003638_abnormal_response/metabolism_1.65018982
27MP0005165_increased_susceptibility_to1.63160986
28MP0000462_abnormal_digestive_system1.58415639
29MP0004782_abnormal_surfactant_physiolog1.54903598
30MP0002118_abnormal_lipid_homeostasis1.50253583
31MP0009840_abnormal_foam_cell1.50226339
32MP0010329_abnormal_lipoprotein_level1.42538670
33MP0008875_abnormal_xenobiotic_pharmacok1.36823889
34MP0003724_increased_susceptibility_to1.28031051
35MP0009780_abnormal_chondrocyte_physiolo1.24795909
36MP0004043_abnormal_pH_regulation1.24791038
37MP0005451_abnormal_body_composition1.21297000
38MP0002078_abnormal_glucose_homeostasis1.20447785
39MP0009643_abnormal_urine_homeostasis1.20294350
40MP0002136_abnormal_kidney_physiology1.16835160
41MP0003436_decreased_susceptibility_to1.16593940
42MP0005332_abnormal_amino_acid1.15709768
43MP0001188_hyperpigmentation1.15048563
44MP0003866_abnormal_defecation1.12380153
45MP0000490_abnormal_crypts_of1.11184978
46MP0003879_abnormal_hair_cell1.09442263
47MP0002234_abnormal_pharynx_morphology1.08720233
48MP0009785_altered_susceptibility_to1.07192472
49MP0005381_digestive/alimentary_phenotyp1.06871304
50MP0001663_abnormal_digestive_system1.06869690
51MP0001790_abnormal_immune_system1.06378380
52MP0005387_immune_system_phenotype1.06378380
53MP0001835_abnormal_antigen_presentation1.05134034
54MP0001501_abnormal_sleep_pattern1.03936094
55MP0002277_abnormal_respiratory_mucosa1.01820347
56MP0002166_altered_tumor_susceptibility1.00977281
57MP0004270_analgesia1.00920806
58MP0006054_spinal_hemorrhage0.99477274
59MP0004019_abnormal_vitamin_homeostasis0.98325392
60MP0005025_abnormal_response_to0.97921476
61MP0003300_gastrointestinal_ulcer0.94919984
62MP0000465_gastrointestinal_hemorrhage0.93445038
63MP0001873_stomach_inflammation0.92493631
64MP0003329_amyloid_beta_deposits0.92185369
65MP0005584_abnormal_enzyme/coenzyme_acti0.90891280
66MP0003953_abnormal_hormone_level0.89350440
67MP0003806_abnormal_nucleotide_metabolis0.88722105
68MP0005670_abnormal_white_adipose0.87370523
69MP0003718_maternal_effect0.84681856
70MP0008469_abnormal_protein_level0.84186266
71MP0000604_amyloidosis0.83449055
72MP0002971_abnormal_brown_adipose0.82843289
73MP0006082_CNS_inflammation0.82100726
74MP0000613_abnormal_salivary_gland0.81312279
75MP0000609_abnormal_liver_physiology0.80373049
76MP0010155_abnormal_intestine_physiology0.77978006
77MP0000470_abnormal_stomach_morphology0.77754057
78MP0005671_abnormal_response_to0.77052935
79MP0003303_peritoneal_inflammation0.76950657
80MP0000003_abnormal_adipose_tissue0.76828878
81MP0005058_abnormal_lysosome_morphology0.76803781
82MP0008789_abnormal_olfactory_epithelium0.76347812
83MP0001765_abnormal_ion_homeostasis0.75501619
84MP0001533_abnormal_skeleton_physiology0.74701634
85MP0002796_impaired_skin_barrier0.74681300
86MP0003045_fibrosis0.73306493
87MP0001485_abnormal_pinna_reflex0.72801833
88MP0005535_abnormal_body_temperature0.71859372
89MP0002098_abnormal_vibrissa_morphology0.71780800
90MP0002909_abnormal_adrenal_gland0.71313380
91MP0000230_abnormal_systemic_arterial0.70800408
92MP0000685_abnormal_immune_system0.70426803
93MP0004233_abnormal_muscle_weight0.69981063
94MP0005408_hypopigmentation0.69615517
95MP0008961_abnormal_basal_metabolism0.69548890
96MP0000013_abnormal_adipose_tissue0.68057268
97MP0009764_decreased_sensitivity_to0.67682938
98MP0002896_abnormal_bone_mineralization0.67604208
99MP0009115_abnormal_fat_cell0.67055228
100MP0004185_abnormal_adipocyte_glucose0.66512337
101MP0002148_abnormal_hypersensitivity_rea0.66034098
102MP0000681_abnormal_thyroid_gland0.65480562
103MP0005375_adipose_tissue_phenotype0.65340050
104MP0000477_abnormal_intestine_morphology0.64994452
105MP0009333_abnormal_splenocyte_physiolog0.64804621
106MP0010678_abnormal_skin_adnexa0.63814654
107MP0002006_tumorigenesis0.62806536
108MP0000249_abnormal_blood_vessel0.61989446
109MP0003075_altered_response_to0.60473933
110MP0001800_abnormal_humoral_immune0.60177394
111MP0005666_abnormal_adipose_tissue0.59683016
112MP0005499_abnormal_olfactory_system0.59545048
113MP0005394_taste/olfaction_phenotype0.59545048
114MP0001756_abnormal_urination0.59135423
115MP0001881_abnormal_mammary_gland0.58629023
116MP0005636_abnormal_mineral_homeostasis0.58555625
117MP0002089_abnormal_postnatal_growth/wei0.58176716
118MP0005000_abnormal_immune_tolerance0.57853818
119MP0000598_abnormal_liver_morphology0.54718739
120MP0002138_abnormal_hepatobiliary_system0.53647164
121MP0008004_abnormal_stomach_pH0.53180113
122MP0009053_abnormal_anal_canal0.51955466
123MP0005334_abnormal_fat_pad0.51694537
124MP0003191_abnormal_cellular_cholesterol0.51634567
125MP0000538_abnormal_urinary_bladder0.51299882
126MP0009642_abnormal_blood_homeostasis0.50063726
127MP0005319_abnormal_enzyme/_coenzyme0.49021695
128MP0005452_abnormal_adipose_tissue0.48625854
129MP0010386_abnormal_urinary_bladder0.48557893
130MP0001764_abnormal_homeostasis0.46801863
131MP0009765_abnormal_xenobiotic_induced0.45198175
132MP0000537_abnormal_urethra_morphology0.43460774
133MP0003566_abnormal_cell_adhesion0.43347259
134MP0001845_abnormal_inflammatory_respons0.41446121
135MP0002877_abnormal_melanocyte_morpholog0.41293601
136MP0008872_abnormal_physiological_respon0.39900647
137MP0000377_abnormal_hair_follicle0.39847517
138MP0003795_abnormal_bone_structure0.39104534
139MP0002822_catalepsy0.38718537
140MP0009384_cardiac_valve_regurgitation0.38401078
141MP0002069_abnormal_eating/drinking_beha0.38036060
142MP0010352_gastrointestinal_tract_polyps0.37188983
143MP0000678_abnormal_parathyroid_gland0.35718861
144MP0002876_abnormal_thyroid_physiology0.35626123
145MP0004947_skin_inflammation0.34659028

Predicted human phenotypes

RankGene SetZ-score
1Fat malabsorption (HP:0002630)7.28808374
2Steatorrhea (HP:0002570)6.88549803
3Systemic lupus erythematosus (HP:0002725)5.44291202
4Chronic diarrhea (HP:0002028)5.07478963
5Abnormality of the vitamin B12 metabolism (HP:0004341)4.83693477
6Abnormality of vitamin B metabolism (HP:0004340)4.54847594
7Exocrine pancreatic insufficiency (HP:0001738)4.43324772
8Flat acetabular roof (HP:0003180)4.11667726
9Widely patent fontanelles and sutures (HP:0004492)3.97713265
10Gout (HP:0001997)3.95401759
11Ketoacidosis (HP:0001993)3.88161025
12Conjugated hyperbilirubinemia (HP:0002908)3.74938146
13Hyperinsulinemic hypoglycemia (HP:0000825)3.68850277
14Confusion (HP:0001289)3.64966405
15Hypoglycemic coma (HP:0001325)3.62894489
16Abnormality of vitamin metabolism (HP:0100508)3.61314816
17Posterior subcapsular cataract (HP:0007787)3.59594681
18Hypoglycemic seizures (HP:0002173)3.58533427
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.55060441
20Pancreatitis (HP:0001733)3.52056006
21Late onset (HP:0003584)3.51069106
22Nausea (HP:0002018)3.49791425
23Abnormality of endocrine pancreas physiology (HP:0012093)3.47188227
24Abnormality of the pancreatic islet cells (HP:0006476)3.47188227
25Abnormality of the intrinsic pathway (HP:0010989)3.46739478
26Congenital sensorineural hearing impairment (HP:0008527)3.42546831
27Abdominal distention (HP:0003270)3.36477100
28Abnormal pancreas size (HP:0012094)3.22412564
29Glomerulonephritis (HP:0000099)3.21877366
30Proximal tubulopathy (HP:0000114)3.19546392
31Ketosis (HP:0001946)3.18833977
32Flattened epiphyses (HP:0003071)3.17650295
33Pigmentary retinal degeneration (HP:0001146)3.17378536
34Decreased circulating renin level (HP:0003351)3.09804882
35Abnormal tarsal ossification (HP:0008369)3.08103532
36Symptomatic seizures (HP:0011145)3.02455086
37Eczematoid dermatitis (HP:0000976)3.00214043
38Wide cranial sutures (HP:0010537)2.98834991
39Thin bony cortex (HP:0002753)2.97385165
40Abnormality of complement system (HP:0005339)2.91117663
41Ileus (HP:0002595)2.90059074
42Nephrolithiasis (HP:0000787)2.87442147
43Villous atrophy (HP:0011473)2.86932217
44Abnormality of small intestinal villus morphology (HP:0011472)2.86932217
45Complement deficiency (HP:0004431)2.86777824
46Alkalosis (HP:0001948)2.84168248
47Hypophosphatemia (HP:0002148)2.83972620
48Hyperparathyroidism (HP:0000843)2.82882812
49Facial shape deformation (HP:0011334)2.82689516
50Potter facies (HP:0002009)2.82689516
51Cupped ribs (HP:0000887)2.82115526
52Hyperglycinuria (HP:0003108)2.80719755
53Decreased subcutaneous fat (HP:0001002)2.79150368
54Right ventricular cardiomyopathy (HP:0011663)2.75637084
55Metabolic alkalosis (HP:0200114)2.75497462
56Flat capital femoral epiphysis (HP:0003370)2.72096041
57Short chin (HP:0000331)2.69300713
58Type I diabetes mellitus (HP:0100651)2.69257639
59Hyperglycemia (HP:0003074)2.67005694
60Abnormality of sulfur amino acid metabolism (HP:0004339)2.65871500
61Hypoproteinemia (HP:0003075)2.63941410
62Intrahepatic cholestasis (HP:0001406)2.61911922
63Abnormality of subcutaneous fat tissue (HP:0001001)2.61696973
64Malnutrition (HP:0004395)2.60675685
65Hyperammonemia (HP:0001987)2.58648118
66Nephritis (HP:0000123)2.57591483
67Hypobetalipoproteinemia (HP:0003563)2.57205302
68Hypoplasia of the pons (HP:0012110)2.53909639
69Megaloblastic anemia (HP:0001889)2.53474834
70Hyperphosphatemia (HP:0002905)2.52381568
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51216147
72Abnormal cartilage morphology (HP:0002763)2.50460930
73Cortical dysplasia (HP:0002539)2.49160325
74Abnormal foot bone ossification (HP:0010675)2.47154757
75Abnormality of the common coagulation pathway (HP:0010990)2.43182887
76Acanthocytosis (HP:0001927)2.41305086
77Hypotension (HP:0002615)2.40735501
78Dysostosis multiplex (HP:0000943)2.40456661
79Hyperactive renin-angiotensin system (HP:0000841)2.39846122
80Abnormality of renin-angiotensin system (HP:0000847)2.37729409
81Abnormality of purine metabolism (HP:0004352)2.34835888
82Abnormality of the pons (HP:0007361)2.32641125
83Carpal bone hypoplasia (HP:0001498)2.32581072
84Hyperphosphaturia (HP:0003109)2.32575942
85Abnormal urine phosphate concentration (HP:0012599)2.31807384
86Hemorrhage of the eye (HP:0011885)2.29791240
87Abnormality of urine glucose concentration (HP:0011016)2.26453761
88Glycosuria (HP:0003076)2.26453761
89Micronodular cirrhosis (HP:0001413)2.24816054
90Abnormality of nucleobase metabolism (HP:0010932)2.24135933
91Abnormality of serine family amino acid metabolism (HP:0010894)2.23182893
92Abnormality of glycine metabolism (HP:0010895)2.23182893
93Dicarboxylic aciduria (HP:0003215)2.22041549
94Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22041549
95Hyperuricemia (HP:0002149)2.18547559
96Increased purine levels (HP:0004368)2.18547559
97Spinal cord compression (HP:0002176)2.17053345
98Focal segmental glomerulosclerosis (HP:0000097)2.16378801
99Limb hypertonia (HP:0002509)2.15321612
100Cerebral palsy (HP:0100021)2.14936414
101Symphalangism affecting the phalanges of the hand (HP:0009773)2.14475898
102Barrel-shaped chest (HP:0001552)2.12776557
103Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12669799
104Abnormal glucose tolerance (HP:0001952)2.12486296
105Vacuolated lymphocytes (HP:0001922)2.11891237
106Ventricular fibrillation (HP:0001663)2.10626953
107Growth hormone excess (HP:0000845)2.09306277
108Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05167619
109Gingivitis (HP:0000230)2.04851489
110Progressive sensorineural hearing impairment (HP:0000408)2.03379011
111Severe short stature (HP:0003510)2.03089178
112Xanthomatosis (HP:0000991)2.02507885
113Subcapsular cataract (HP:0000523)2.02132414
114Gastrointestinal dysmotility (HP:0002579)2.02118769
115Enlarged epiphyses (HP:0010580)2.01955579
116Vertebral clefting (HP:0008428)2.01783901
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01452308
118Hypolipoproteinemia (HP:0010981)1.98618867
119Metabolic acidosis (HP:0001942)1.98476514
120Esophageal varix (HP:0002040)1.97555305
121Hyperglycinemia (HP:0002154)1.97040098
122Protuberant abdomen (HP:0001538)1.96799972
123Irregular epiphyses (HP:0010582)1.96417229
124Premature skin wrinkling (HP:0100678)1.94457513
125Neonatal short-limb short stature (HP:0008921)1.93547421
126Maternal diabetes (HP:0009800)1.93001131
127Renal tubular acidosis (HP:0001947)1.92866541
128Abnormality of the costochondral junction (HP:0000919)1.92168609
129Insulin resistance (HP:0000855)1.91640790
130Vertebral hypoplasia (HP:0008417)1.91591082
131Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.91591082
132Urinary glycosaminoglycan excretion (HP:0003541)1.91450789
133Mucopolysacchariduria (HP:0008155)1.91450789
134Abnormality of magnesium homeostasis (HP:0004921)1.90408587
135Prolonged QT interval (HP:0001657)1.89990512
136Hypsarrhythmia (HP:0002521)1.89882928
137Insulin-resistant diabetes mellitus (HP:0000831)1.89781425
138Fatigue (HP:0012378)1.89206294
139Delayed epiphyseal ossification (HP:0002663)1.87990908
140Hydroxyprolinuria (HP:0003080)1.87509395
141Abnormality of proline metabolism (HP:0010907)1.87509395
142Large for gestational age (HP:0001520)1.85774473
143Acute hepatic failure (HP:0006554)1.85489142
144Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85141187
145Gastrointestinal stroma tumor (HP:0100723)1.84850695
146Progressive hearing impairment (HP:0001730)1.84705803
147EEG with generalized epileptiform discharges (HP:0011198)1.82046588
148Pancreatic islet-cell hyperplasia (HP:0004510)1.80982273
149Abnormal protein glycosylation (HP:0012346)1.80608446
150Abnormal glycosylation (HP:0012345)1.80608446
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.80608446
152Abnormal protein N-linked glycosylation (HP:0012347)1.80608446
153Abnormal vertebral ossification (HP:0100569)1.80351567
154Abnormal biliary tract morphology (HP:0012440)1.78151716
155Syncope (HP:0001279)1.77435168
156Hypoalbuminemia (HP:0003073)1.76335192
157Abnormal albumin level (HP:0012116)1.76335192
158Abnormality of pyrimidine metabolism (HP:0004353)1.76222970
159Irritability (HP:0000737)1.76125684
160Emphysema (HP:0002097)1.73934657
161Epidermoid cyst (HP:0200040)1.71975788
162Multiple lipomas (HP:0001012)1.71490384
163Hypocalcemia (HP:0002901)1.71274925
164Bone cyst (HP:0012062)1.71113006
165Petechiae (HP:0000967)1.71001341
166Pili torti (HP:0003777)1.69518883
167Skin rash (HP:0000988)1.69288490
168Glomerulosclerosis (HP:0000096)1.69039457

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK39.59672018
2ACVR1B6.46564232
3BCKDK4.84500627
4FRK4.38733564
5MAP2K24.05690557
6ERN13.66966210
7TRIB32.66469826
8EIF2AK32.60282969
9FGFR42.56566320
10INSRR2.45620065
11EPHB22.34947167
12PKN22.20114028
13TYK22.19227700
14NME12.18664438
15MAP3K21.93897506
16OXSR11.91678262
17PTK61.89261009
18MAP3K121.76678330
19MAP4K11.67360109
20MAP2K11.66745456
21TESK21.58006837
22MAPK151.49197776
23EPHA21.48452833
24STK241.47991623
25RIPK11.39175055
26MYLK1.34223131
27FGFR31.30792001
28PRPF4B1.26877291
29RIPK41.23959738
30FLT31.23387149
31SCYL21.17835951
32NLK1.17088377
33MST1R1.15825326
34KSR21.15432625
35IRAK31.10199513
36GRK61.09712477
37MAPKAPK31.03961958
38LMTK21.03638037
39LATS11.02959827
40RPS6KB20.96588888
41TNIK0.95380856
42WNK40.95142464
43ZAP700.94317226
44MAP3K90.93430240
45JAK10.93237357
46PRKG20.91061730
47PAK20.91008686
48PIK3CA0.89435089
49PTK20.87698132
50MAP3K10.86622612
51TAOK10.86553048
52IRAK10.85369186
53MAP3K110.84018825
54MET0.83295450
55NTRK10.79209140
56CAMKK10.79122028
57IKBKE0.78558554
58DYRK1A0.76538319
59MST40.66434594
60EEF2K0.65243066
61MAP2K60.64434613
62BMPR20.63727266
63CDK190.62784425
64ILK0.62202764
65EPHA40.61571793
66JAK30.60988973
67GRK10.60307765
68KIT0.60214886
69PDGFRB0.57137868
70PRKD30.56746217
71PDGFRA0.54787815
72FER0.54610318
73RET0.53999284
74TGFBR20.52094554
75DYRK1B0.47212855
76SRC0.46424869
77CSF1R0.45956129
78PIK3CG0.45503035
79PDPK10.44457527
80PRKCI0.44389045
81BMX0.43851760
82HIPK20.43460224
83CAMKK20.43104427
84ICK0.42124246
85FYN0.41799963
86NUAK10.41357530
87EPHB10.40936558
88PASK0.39744057
89MAPK110.39428419
90PAK40.38516301
91CASK0.38279458
92PRKCD0.37939416
93STK390.37729715
94PDK10.37700047
95IRAK40.37457361
96PDK20.37418135
97ABL20.37077986
98PRKCH0.36932210
99NME20.36026073
100LRRK20.36017126
101YES10.35411976
102BTK0.35083654
103PRKCZ0.34941129
104SYK0.33958384
105EPHA30.33749408
106LYN0.33079147
107AKT30.32991623
108PRKCQ0.32911354
109MAP3K70.32384597
110BLK0.32174193
111CAMK2D0.31676213
112JAK20.30326790
113MTOR0.30246461
114NTRK30.30237922
115CAMK2G0.29651091
116MAP3K80.28784885
117NEK60.28722453
118RPS6KB10.27800839
119TBK10.27496176
120LCK0.26966230
121MAP3K100.26106332
122PIM10.25818132
123DMPK0.24482436
124CAMK2B0.24064445
125MAP3K140.23323009
126SMG10.23053088
127MAPK70.23016234
128IRAK20.20733366
129DAPK20.17974436
130PRKD10.17479673
131MAP3K30.17475905
132SIK10.17321483
133TESK10.17254049
134PRKAA20.16832239
135ERBB20.16526995
136DDR20.16421653
137PRKCA0.16216619
138PRKD20.16189066
139GSK3A0.15477674
140CSK0.15083567
141PRKAA10.13600380
142CDC42BPA0.13518888
143MATK0.12979007
144PRKACG0.12253150
145ITK0.11458473
146CDK50.09303761
147IGF1R0.09114329

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049756.99695608
2Pancreatic secretion_Homo sapiens_hsa049726.16633945
3Protein digestion and absorption_Homo sapiens_hsa049744.38425934
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.96243106
5Vitamin digestion and absorption_Homo sapiens_hsa049772.71317287
6Glycerolipid metabolism_Homo sapiens_hsa005612.65235009
7Renin-angiotensin system_Homo sapiens_hsa046142.64926745
8Folate biosynthesis_Homo sapiens_hsa007902.62393897
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.54404817
10Protein export_Homo sapiens_hsa030602.27367582
11Sulfur metabolism_Homo sapiens_hsa009202.08250099
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.03304904
13Asthma_Homo sapiens_hsa053101.85169901
14Cyanoamino acid metabolism_Homo sapiens_hsa004601.84015967
15Starch and sucrose metabolism_Homo sapiens_hsa005001.78907959
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69340740
17Steroid biosynthesis_Homo sapiens_hsa001001.64151610
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.52274788
19Retinol metabolism_Homo sapiens_hsa008301.45098811
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41923989
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38048657
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.33775307
23Galactose metabolism_Homo sapiens_hsa000521.33457017
24Allograft rejection_Homo sapiens_hsa053301.33226379
25Staphylococcus aureus infection_Homo sapiens_hsa051501.30055242
26Linoleic acid metabolism_Homo sapiens_hsa005911.28211877
27Mineral absorption_Homo sapiens_hsa049781.27478755
28Autoimmune thyroid disease_Homo sapiens_hsa053201.25572716
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22006410
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21270749
31Graft-versus-host disease_Homo sapiens_hsa053321.19367810
32Type I diabetes mellitus_Homo sapiens_hsa049401.11056917
33Fructose and mannose metabolism_Homo sapiens_hsa000511.05185976
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.03006064
35Propanoate metabolism_Homo sapiens_hsa006401.01228579
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99674146
37Insulin secretion_Homo sapiens_hsa049110.96965804
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93204869
39Bile secretion_Homo sapiens_hsa049760.89757928
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88467376
41Selenocompound metabolism_Homo sapiens_hsa004500.87494331
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86207757
43Arginine and proline metabolism_Homo sapiens_hsa003300.84287677
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81023570
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79235876
46Antigen processing and presentation_Homo sapiens_hsa046120.73273873
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70850121
48Tryptophan metabolism_Homo sapiens_hsa003800.70235447
49Nitrogen metabolism_Homo sapiens_hsa009100.69425569
50Type II diabetes mellitus_Homo sapiens_hsa049300.65941213
51Leishmaniasis_Homo sapiens_hsa051400.65592571
52Biosynthesis of amino acids_Homo sapiens_hsa012300.64976010
53Glutathione metabolism_Homo sapiens_hsa004800.63781859
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62961356
55Arginine biosynthesis_Homo sapiens_hsa002200.62128750
56N-Glycan biosynthesis_Homo sapiens_hsa005100.61243104
57Phenylalanine metabolism_Homo sapiens_hsa003600.59756253
58Vibrio cholerae infection_Homo sapiens_hsa051100.58874272
59Fatty acid degradation_Homo sapiens_hsa000710.57823185
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57696482
61Other glycan degradation_Homo sapiens_hsa005110.55972533
62Histidine metabolism_Homo sapiens_hsa003400.55538656
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54657007
64Caffeine metabolism_Homo sapiens_hsa002320.51789292
65Pyruvate metabolism_Homo sapiens_hsa006200.51581641
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50255702
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49978779
68Pertussis_Homo sapiens_hsa051330.49685348
69Arachidonic acid metabolism_Homo sapiens_hsa005900.48288625
70PPAR signaling pathway_Homo sapiens_hsa033200.48237731
71Influenza A_Homo sapiens_hsa051640.47892373
72Viral myocarditis_Homo sapiens_hsa054160.45546123
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43405571
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42741383
75Peroxisome_Homo sapiens_hsa041460.40230985
76Ether lipid metabolism_Homo sapiens_hsa005650.39804334
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39685198
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38624730
79Carbon metabolism_Homo sapiens_hsa012000.38319906
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38200184
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.36948904
82Renin secretion_Homo sapiens_hsa049240.36492244
83Endometrial cancer_Homo sapiens_hsa052130.35304240
84Alzheimers disease_Homo sapiens_hsa050100.33769191
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33550686
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33093872
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.32429798
88beta-Alanine metabolism_Homo sapiens_hsa004100.32282801
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32098816
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31590170
91Toxoplasmosis_Homo sapiens_hsa051450.31571095
92Thyroid hormone synthesis_Homo sapiens_hsa049180.31226576
93Tyrosine metabolism_Homo sapiens_hsa003500.29850569
94Pentose phosphate pathway_Homo sapiens_hsa000300.29772358
95Legionellosis_Homo sapiens_hsa051340.28095295
96VEGF signaling pathway_Homo sapiens_hsa043700.27856775
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27581678
98Hematopoietic cell lineage_Homo sapiens_hsa046400.25462956
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25331278
100Metabolic pathways_Homo sapiens_hsa011000.24664577
101Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23732362
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23678228
103Cocaine addiction_Homo sapiens_hsa050300.23643885
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.23437276
105Lysosome_Homo sapiens_hsa041420.22756576
106Adipocytokine signaling pathway_Homo sapiens_hsa049200.21534985
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.20782742
108Chemical carcinogenesis_Homo sapiens_hsa052040.20729069
109Rheumatoid arthritis_Homo sapiens_hsa053230.20373711
110Insulin resistance_Homo sapiens_hsa049310.20155447
111Butanoate metabolism_Homo sapiens_hsa006500.19897159
112Complement and coagulation cascades_Homo sapiens_hsa046100.18634944
113Hepatitis C_Homo sapiens_hsa051600.18435882
114Sphingolipid metabolism_Homo sapiens_hsa006000.18165294
115Tuberculosis_Homo sapiens_hsa051520.18147614
116Chemokine signaling pathway_Homo sapiens_hsa040620.18085577
117Parkinsons disease_Homo sapiens_hsa050120.17451399
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.17377246
119Fatty acid biosynthesis_Homo sapiens_hsa000610.17304484
120Tight junction_Homo sapiens_hsa045300.16985322
121Sulfur relay system_Homo sapiens_hsa041220.16863835
122Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.16777810
123Estrogen signaling pathway_Homo sapiens_hsa049150.12235246
124ABC transporters_Homo sapiens_hsa020100.12231346
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.11966846
126Central carbon metabolism in cancer_Homo sapiens_hsa052300.11663675
127Insulin signaling pathway_Homo sapiens_hsa049100.11233267
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.08489772
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.07381571
130Fatty acid elongation_Homo sapiens_hsa000620.06986902
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.06843401
132One carbon pool by folate_Homo sapiens_hsa006700.06467653
133African trypanosomiasis_Homo sapiens_hsa051430.05691909
134Non-small cell lung cancer_Homo sapiens_hsa052230.05250734
135Oxidative phosphorylation_Homo sapiens_hsa001900.04978520
136Fatty acid metabolism_Homo sapiens_hsa012120.04528645
137Salivary secretion_Homo sapiens_hsa049700.04142198

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