REG4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1UDP-N-acetylglucosamine metabolic process (GO:0006047)8.28704947
2intestinal absorption (GO:0050892)7.87400677
3intestinal epithelial cell development (GO:0060576)7.71852826
4maintenance of gastrointestinal epithelium (GO:0030277)7.68135914
5regulation of guanylate cyclase activity (GO:0031282)7.17363609
6bundle of His cell to Purkinje myocyte communication (GO:0086069)6.71753642
7epithelial structure maintenance (GO:0010669)6.08973913
8NADH metabolic process (GO:0006734)6.07471973
9positive regulation of respiratory burst (GO:0060267)5.74260980
10O-glycan processing (GO:0016266)5.55576372
11digestive system process (GO:0022600)5.48922266
12actin filament depolymerization (GO:0030042)5.39862485
13intestinal cholesterol absorption (GO:0030299)5.37743468
14flavonoid metabolic process (GO:0009812)5.19569337
15positive regulation of guanylate cyclase activity (GO:0031284)5.18633898
16bile acid and bile salt transport (GO:0015721)5.15724051
17lipoprotein transport (GO:0042953)5.01100392
18sulfation (GO:0051923)4.98169779
19regulation of respiratory burst (GO:0060263)4.88765753
20lung secretory cell differentiation (GO:0061140)4.84843682
21epoxygenase P450 pathway (GO:0019373)4.84068331
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.83870605
23fat-soluble vitamin biosynthetic process (GO:0042362)4.76284033
24glomerular filtration (GO:0003094)4.66597097
25angiotensin maturation (GO:0002003)4.63586345
26vitamin A metabolic process (GO:0006776)4.62685070
27regulation of systemic arterial blood pressure by hormone (GO:0001990)4.60117422
28regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.60117422
29endocrine process (GO:0050886)4.60117422
30purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.54294924
313-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.54294924
32sulfate transmembrane transport (GO:1902358)4.45617255
33fructose metabolic process (GO:0006000)4.44483914
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43228796
35transcytosis (GO:0045056)4.40097781
36hormone catabolic process (GO:0042447)4.39150892
37regulation of cGMP biosynthetic process (GO:0030826)4.34133904
38regulation of cellular extravasation (GO:0002691)4.30460754
39ethanol metabolic process (GO:0006067)4.29115259
40membrane repolarization during cardiac muscle cell action potential (GO:0086013)4.28360040
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.26723222
42antibacterial humoral response (GO:0019731)4.25495121
43renal filtration (GO:0097205)4.25403114
44regulation of systemic arterial blood pressure (GO:0003073)4.24246738
45antimicrobial humoral response (GO:0019730)4.23722724
46complement activation, classical pathway (GO:0006958)4.19422634
47hepatocyte apoptotic process (GO:0097284)4.19379710
48regulation of pseudopodium assembly (GO:0031272)4.19226663
49nucleotide-sugar biosynthetic process (GO:0009226)4.16220901
50primary alcohol catabolic process (GO:0034310)4.15895247
51ventricular cardiac muscle cell action potential (GO:0086005)4.13977931
52urea cycle (GO:0000050)4.09680987
53regulation of bile acid biosynthetic process (GO:0070857)4.08794402
54diacylglycerol metabolic process (GO:0046339)4.07116662
55sperm capacitation (GO:0048240)4.05286293
56antigen processing and presentation of endogenous antigen (GO:0019883)4.02596766
57regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.01910013
58regulation of hydrogen peroxide metabolic process (GO:0010310)4.01380210
59nucleotide-sugar metabolic process (GO:0009225)3.96432225
60bicarbonate transport (GO:0015701)3.95645551
61peptide catabolic process (GO:0043171)3.93717782
62galactose catabolic process (GO:0019388)3.93269696
63desmosome organization (GO:0002934)3.87788140
64urea metabolic process (GO:0019627)3.86143144
65regulation of vitamin metabolic process (GO:0030656)3.80692066
66eosinophil chemotaxis (GO:0048245)3.79597119
67peptide hormone processing (GO:0016486)3.78953723
68membrane repolarization during action potential (GO:0086011)3.78321918
69regulation of cholesterol homeostasis (GO:2000188)3.78084583
70renal system process involved in regulation of blood volume (GO:0001977)3.70022371
71drug metabolic process (GO:0017144)3.66339254
72sulfate transport (GO:0008272)3.62506382
73very-low-density lipoprotein particle assembly (GO:0034379)3.61802540
74drug catabolic process (GO:0042737)3.60447949
75arginine metabolic process (GO:0006525)3.60275407
76nitrogen cycle metabolic process (GO:0071941)3.59859870
77regulation of cGMP metabolic process (GO:0030823)3.59440924
78sulfur amino acid catabolic process (GO:0000098)3.57511839
79disruption of cells of other organism (GO:0044364)3.56292554
80killing of cells of other organism (GO:0031640)3.56292554
81regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.55323779
82regulation of chemokine secretion (GO:0090196)3.54756478
83glandular epithelial cell differentiation (GO:0002067)3.53203736
84glycolipid catabolic process (GO:0019377)3.50756886
85glycosphingolipid catabolic process (GO:0046479)3.50417866
86striated muscle atrophy (GO:0014891)3.48895863
87protein O-linked glycosylation (GO:0006493)3.47828416
88defense response to fungus (GO:0050832)3.46618590
89oligosaccharide biosynthetic process (GO:0009312)3.45411281
90sulfur compound transport (GO:0072348)3.44973654
91adhesion of symbiont to host (GO:0044406)3.40597096
92cGMP-mediated signaling (GO:0019934)3.40504988
93GDP-mannose metabolic process (GO:0019673)3.40301349
94virion attachment to host cell (GO:0019062)3.38531497
95adhesion of symbiont to host cell (GO:0044650)3.38531497
96hemidesmosome assembly (GO:0031581)3.38063969
97eosinophil migration (GO:0072677)3.37903329
98pyrimidine-containing compound transmembrane transport (GO:0072531)3.36706419
99regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.35613125
100negative regulation of keratinocyte proliferation (GO:0010839)3.34521384
101complement activation (GO:0006956)3.26280362
102response to hepatocyte growth factor (GO:0035728)3.25050860
103cellular response to hepatocyte growth factor stimulus (GO:0035729)3.25050860
104positive regulation of Cdc42 GTPase activity (GO:0043089)3.22703639
105alkaloid metabolic process (GO:0009820)3.22659096
106digestion (GO:0007586)3.22139380
107regulation of heart rate by cardiac conduction (GO:0086091)3.20444484
108transepithelial transport (GO:0070633)3.17997030
109proline biosynthetic process (GO:0006561)3.17774029
110cell differentiation involved in embryonic placenta development (GO:0060706)3.16705893
111detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.15861355
112cellular glucuronidation (GO:0052695)3.15245094
113positive regulation of epidermal cell differentiation (GO:0045606)3.14402261
114cell communication involved in cardiac conduction (GO:0086065)3.14148705
115midgut development (GO:0007494)3.09366080
116phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.06767438
117positive regulation of glycoprotein biosynthetic process (GO:0010560)3.06573681
118nucleoside diphosphate biosynthetic process (GO:0009133)3.06482785
119auditory receptor cell differentiation (GO:0042491)3.05350099
120plasma lipoprotein particle assembly (GO:0034377)3.04496816
121epithelial cell-cell adhesion (GO:0090136)3.04483493
122cardiac conduction (GO:0061337)3.03676453
123tight junction assembly (GO:0070830)3.02460107
124skeletal muscle adaptation (GO:0043501)3.01613569
125regulation of triglyceride catabolic process (GO:0010896)3.01332360
126lipoprotein metabolic process (GO:0042157)3.01200234
127regulation of actin nucleation (GO:0051125)3.00347445
128sexual reproduction (GO:0019953)2.99944666
129trophectodermal cell differentiation (GO:0001829)2.97520921
130positive regulation of cGMP biosynthetic process (GO:0030828)2.96952986
131glutamine family amino acid biosynthetic process (GO:0009084)2.96837989
132diol metabolic process (GO:0034311)2.94732233
133positive regulation of actin filament depolymerization (GO:0030836)2.93366745
134phosphatidylserine acyl-chain remodeling (GO:0036150)2.92522474
135thrombin receptor signaling pathway (GO:0070493)2.92409573
136protein-lipid complex assembly (GO:0065005)2.91266191
137homocysteine metabolic process (GO:0050667)2.91092170
138glucuronate metabolic process (GO:0019585)2.90783869
139uronic acid metabolic process (GO:0006063)2.90783869
140phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.89391217
141vitamin transmembrane transport (GO:0035461)2.89376860
142glucose 6-phosphate metabolic process (GO:0051156)2.87245398
143receptor guanylyl cyclase signaling pathway (GO:0007168)2.86020745
144endocrine pancreas development (GO:0031018)2.85397846
145positive regulation of glycoprotein metabolic process (GO:1903020)2.84671120
146muscle atrophy (GO:0014889)2.83742757
147galactose metabolic process (GO:0006012)2.83721120
148sphingomyelin metabolic process (GO:0006684)2.81260467
149ceramide catabolic process (GO:0046514)2.81132745
150amino sugar metabolic process (GO:0006040)2.80974096
151protein autoprocessing (GO:0016540)2.80868814
152sphingolipid catabolic process (GO:0030149)2.80608218
153low-density lipoprotein particle remodeling (GO:0034374)2.77757134
154thyroid hormone metabolic process (GO:0042403)2.76946649
155cyclooxygenase pathway (GO:0019371)2.74789398
156positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.73581482
157positive regulation of pseudopodium assembly (GO:0031274)2.73034821
158fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73023854
159vitamin transport (GO:0051180)2.70118445
160glycosylceramide metabolic process (GO:0006677)2.69985879
161negative regulation of protein tyrosine kinase activity (GO:0061099)2.68955733
162arginine catabolic process (GO:0006527)2.68787492
163columnar/cuboidal epithelial cell development (GO:0002066)2.68134284
164positive regulation of digestive system process (GO:0060456)2.67609682
165bile acid metabolic process (GO:0008206)2.65940563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.56308163
2CDX2_20551321_ChIP-Seq_CACO-2_Human5.86720280
3SOX2_27498859_Chip-Seq_STOMACH_Mouse4.23536184
4* GATA4_25053715_ChIP-Seq_YYC3_Human3.25033909
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.24958189
6* SOX2_20726797_ChIP-Seq_SW620_Human3.12410524
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.12285047
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.03939970
9* GATA6_25053715_ChIP-Seq_YYC3_Human2.99277627
10HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.92281022
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.81751327
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.78462575
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.57651379
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52110919
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.51968740
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.43084411
17FOXO3_23340844_ChIP-Seq_DLD1_Human2.16045811
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.12504751
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.07584340
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.03376569
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.99566523
22ESR2_21235772_ChIP-Seq_MCF-7_Human1.98436704
23RUNX1_27514584_Chip-Seq_MCF-7_Human1.97830142
24FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.89151503
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.88748865
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.87242310
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81450977
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81348641
29KLF5_25053715_ChIP-Seq_YYC3_Human1.81098104
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.79265465
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78289619
32* LXR_22158963_ChIP-Seq_LIVER_Mouse1.76749312
33CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74546261
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.72428848
35RACK7_27058665_Chip-Seq_MCF-7_Human1.69280683
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63554800
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.63515521
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.63011398
39ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62505939
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59073953
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.57845122
42ATF3_27146783_Chip-Seq_COLON_Human1.56450262
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.56209945
44KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55961894
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.54551507
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54299490
47AR_21909140_ChIP-Seq_LNCAP_Human1.49787698
48ZNF263_19887448_ChIP-Seq_K562_Human1.45813127
49GATA1_22025678_ChIP-Seq_K562_Human1.44397748
50* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41286993
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34138488
52BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.30346157
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.30051275
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23397070
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23397070
56* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23314143
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20788664
58CREB1_26743006_Chip-Seq_LNCaP_Human1.20738266
59GATA2_19941826_ChIP-Seq_K562_Human1.18797188
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18004902
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16419526
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12423852
63EGR1_19032775_ChIP-ChIP_M12_Human1.12010940
64DROSHA_22980978_ChIP-Seq_HELA_Human1.10052675
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09003501
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08685744
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.08584876
68SA1_27219007_Chip-Seq_Bcells_Human1.08049331
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07273971
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06842623
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06107090
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.06054468
73JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04972071
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04734934
75SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04420532
76BCOR_27268052_Chip-Seq_Bcells_Human1.03492150
77JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02903558
78BCL6_27268052_Chip-Seq_Bcells_Human1.02192282
79GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01762580
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01686884
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01339352
82* HNF4A_19822575_ChIP-Seq_HepG2_Human1.01072126
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00937404
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00404444
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00253512
86VDR_24763502_ChIP-Seq_THP-1_Human0.99526050
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99122601
88* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99001149
89GATA3_24758297_ChIP-Seq_MCF-7_Human0.97700134
90POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.97336510
91* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97225881
92* LXR_22292898_ChIP-Seq_THP-1_Human0.96527387
93RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96483019
94FOXA1_25552417_ChIP-Seq_VCAP_Human0.96239557
95NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95244670
96GATA1_19941826_ChIP-Seq_K562_Human0.95224695
97CLOCK_20551151_ChIP-Seq_293T_Human0.94672468
98ELF5_23300383_ChIP-Seq_T47D_Human0.94619942
99UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93238844
100PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93071782
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91163656
102DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90980366
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90487017
104ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89826870
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89354862
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.89291385
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.89041087
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88991172
109GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87318850
110CEBPB_22108803_ChIP-Seq_LS180_Human0.85674411
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.84081868
112CTCF_27219007_Chip-Seq_Bcells_Human0.83856593
113CDX2_22108803_ChIP-Seq_LS180_Human0.80857874
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80696193
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80479920
116* PHF8_20622854_ChIP-Seq_HELA_Human0.80130207
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79926543
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79813560
119TP63_22573176_ChIP-Seq_HFKS_Human0.79493879
120* BCAT_22108803_ChIP-Seq_LS180_Human0.79035557
121Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79019776
122STAT4_19710469_ChIP-ChIP_TH1__Mouse0.78285535
123MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78122265
124VDR_22108803_ChIP-Seq_LS180_Human0.77848765
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.76987207
126GATA1_26923725_Chip-Seq_HPCs_Mouse0.76784101
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.76485664
128* NANOG_20526341_ChIP-Seq_ESCs_Human0.76456031
129RXR_22108803_ChIP-Seq_LS180_Human0.76381477
130IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74897537
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74591939
132EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.74359501
133NANOG_18692474_ChIP-Seq_MEFs_Mouse0.73671474
134* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73378920
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.73243791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.57552466
2MP0005360_urolithiasis4.62466155
3MP0003866_abnormal_defecation4.56186009
4MP0004264_abnormal_extraembryonic_tissu4.34685426
5MP0001666_abnormal_nutrient_absorption3.99352113
6MP0000462_abnormal_digestive_system3.96307115
7MP0001663_abnormal_digestive_system3.94344412
8MP0001873_stomach_inflammation3.93251078
9MP0005381_digestive/alimentary_phenotyp3.53714153
10MP0010155_abnormal_intestine_physiology3.43990132
11MP0000490_abnormal_crypts_of3.11411762
12MP0000537_abnormal_urethra_morphology3.04288257
13MP0010352_gastrointestinal_tract_polyps2.82729574
14MP0005085_abnormal_gallbladder_physiolo2.77172686
15MP0002822_catalepsy2.70539751
16MP0000477_abnormal_intestine_morphology2.63210669
17MP0003300_gastrointestinal_ulcer2.62479758
18MP0001664_abnormal_digestion2.49809458
19MP0003252_abnormal_bile_duct2.21652968
20MP0004858_abnormal_nervous_system2.20737444
21MP0002139_abnormal_hepatobiliary_system2.08989202
22MP0006054_spinal_hemorrhage2.04487729
23MP0003878_abnormal_ear_physiology2.01557340
24MP0005377_hearing/vestibular/ear_phenot2.01557340
25MP0008875_abnormal_xenobiotic_pharmacok1.98049761
26MP0004043_abnormal_pH_regulation1.94132489
27MP0005409_darkened_coat_color1.94119696
28MP0003705_abnormal_hypodermis_morpholog1.86539094
29MP0008004_abnormal_stomach_pH1.83917774
30MP0004782_abnormal_surfactant_physiolog1.83442613
31MP0003283_abnormal_digestive_organ1.68869764
32MP0005365_abnormal_bile_salt1.58061857
33MP0009840_abnormal_foam_cell1.56112735
34MP0005167_abnormal_blood-brain_barrier1.55296861
35MP0000538_abnormal_urinary_bladder1.48546745
36MP0009379_abnormal_foot_pigmentation1.48499522
37MP0003724_increased_susceptibility_to1.47779887
38MP0002796_impaired_skin_barrier1.47681745
39MP0005166_decreased_susceptibility_to1.42909266
40MP0010678_abnormal_skin_adnexa1.42194004
41MP0002277_abnormal_respiratory_mucosa1.41427770
42MP0010329_abnormal_lipoprotein_level1.37885174
43MP0003868_abnormal_feces_composition1.36791884
44MP0001849_ear_inflammation1.36531962
45MP0008872_abnormal_physiological_respon1.35033260
46MP0000678_abnormal_parathyroid_gland1.31357261
47MP0004147_increased_porphyrin_level1.28464472
48MP0000467_abnormal_esophagus_morphology1.28169876
49MP0000470_abnormal_stomach_morphology1.25033638
50MP0002166_altered_tumor_susceptibility1.24928888
51MP0004019_abnormal_vitamin_homeostasis1.22953535
52MP0001765_abnormal_ion_homeostasis1.22725921
53MP0003303_peritoneal_inflammation1.21456903
54MP0001764_abnormal_homeostasis1.20805057
55MP0001835_abnormal_antigen_presentation1.17956387
56MP0003315_abnormal_perineum_morphology1.16038257
57MP0003329_amyloid_beta_deposits1.15797745
58MP0003453_abnormal_keratinocyte_physiol1.14699974
59MP0001188_hyperpigmentation1.12591842
60MP0009643_abnormal_urine_homeostasis1.11688678
61MP0001790_abnormal_immune_system1.10919249
62MP0005387_immune_system_phenotype1.10919249
63MP0003806_abnormal_nucleotide_metabolis1.09422200
64MP0003436_decreased_susceptibility_to1.09095704
65MP0001501_abnormal_sleep_pattern1.08636408
66MP0006082_CNS_inflammation1.04930425
67MP0002098_abnormal_vibrissa_morphology1.03620567
68MP0003191_abnormal_cellular_cholesterol0.99768825
69MP0005501_abnormal_skin_physiology0.96862108
70MP0000604_amyloidosis0.93795673
71MP0003183_abnormal_peptide_metabolism0.93669950
72MP0002138_abnormal_hepatobiliary_system0.92014105
73MP0003693_abnormal_embryo_hatching0.91985790
74MP0005636_abnormal_mineral_homeostasis0.89909469
75MP0004270_analgesia0.89185227
76MP0002006_tumorigenesis0.87164893
77MP0005310_abnormal_salivary_gland0.86795646
78MP0005584_abnormal_enzyme/coenzyme_acti0.85635897
79MP0004947_skin_inflammation0.85154219
80MP0000613_abnormal_salivary_gland0.83581581
81MP0005671_abnormal_response_to0.83364689
82MP0001216_abnormal_epidermal_layer0.82916733
83MP0005670_abnormal_white_adipose0.81758958
84MP0008469_abnormal_protein_level0.81163128
85MP0002148_abnormal_hypersensitivity_rea0.81110250
86MP0000465_gastrointestinal_hemorrhage0.79951514
87MP0002971_abnormal_brown_adipose0.79772074
88MP0001800_abnormal_humoral_immune0.79451146
89MP0001533_abnormal_skeleton_physiology0.78410506
90MP0002896_abnormal_bone_mineralization0.77351390
91MP0005257_abnormal_intraocular_pressure0.76592685
92MP0005187_abnormal_penis_morphology0.75538301
93MP0005535_abnormal_body_temperature0.74642628
94MP0009333_abnormal_splenocyte_physiolog0.73467481
95MP0002060_abnormal_skin_morphology0.71985136
96MP0003075_altered_response_to0.70974848
97MP0000230_abnormal_systemic_arterial0.69498812
98MP0000516_abnormal_urinary_system0.67521946
99MP0005367_renal/urinary_system_phenotyp0.67521946
100MP0001881_abnormal_mammary_gland0.66564870
101MP0005058_abnormal_lysosome_morphology0.66150086
102MP0000249_abnormal_blood_vessel0.66135927
103MP0002254_reproductive_system_inflammat0.65659570
104MP0001485_abnormal_pinna_reflex0.65021926
105MP0003448_altered_tumor_morphology0.63615298
106MP0009115_abnormal_fat_cell0.62618680
107MP0002998_abnormal_bone_remodeling0.60988311
108MP0002909_abnormal_adrenal_gland0.60958626
109MP0005000_abnormal_immune_tolerance0.60867394
110MP0004484_altered_response_of0.60497272
111MP0001845_abnormal_inflammatory_respons0.59303242
112MP0002452_abnormal_antigen_presenting0.58905829
113MP0004185_abnormal_adipocyte_glucose0.58565674
114MP0005319_abnormal_enzyme/_coenzyme0.58070932
115MP0000609_abnormal_liver_physiology0.57810195
116MP0005332_abnormal_amino_acid0.57379869
117MP0009384_cardiac_valve_regurgitation0.57314012
118MP0009764_decreased_sensitivity_to0.56887458
119MP0002118_abnormal_lipid_homeostasis0.55860905
120MP0003119_abnormal_digestive_system0.55663490
121MP0002136_abnormal_kidney_physiology0.54483814
122MP0010386_abnormal_urinary_bladder0.54437748
123MP0010771_integument_phenotype0.54193673
124MP0005448_abnormal_energy_balance0.53455538
125MP0005165_increased_susceptibility_to0.53259331
126MP0003045_fibrosis0.53153990
127MP0009053_abnormal_anal_canal0.52358491
128MP0002132_abnormal_respiratory_system0.50684862
129MP0002089_abnormal_postnatal_growth/wei0.50058217
130MP0003566_abnormal_cell_adhesion0.49414667
131MP0000762_abnormal_tongue_morphology0.48408955
132MP0003941_abnormal_skin_development0.46653531
133MP0005451_abnormal_body_composition0.45999766
134MP0003879_abnormal_hair_cell0.45653250
135MP0000377_abnormal_hair_follicle0.44737385
136MP0001756_abnormal_urination0.44020836
137MP0002876_abnormal_thyroid_physiology0.43072010
138MP0005025_abnormal_response_to0.42441560
139MP0009785_altered_susceptibility_to0.41341197
140MP0005084_abnormal_gallbladder_morpholo0.40098268
141MP0003718_maternal_effect0.39671776

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)9.11346782
2Right ventricular cardiomyopathy (HP:0011663)7.07045234
3Malnutrition (HP:0004395)5.24108072
4Systemic lupus erythematosus (HP:0002725)5.13598272
5Hyperactive renin-angiotensin system (HP:0000841)5.00897660
6Ventricular fibrillation (HP:0001663)4.98995028
7Abdominal distention (HP:0003270)4.72996755
8Metabolic alkalosis (HP:0200114)4.48030219
9Congenital sensorineural hearing impairment (HP:0008527)4.18939431
10Abnormality of chloride homeostasis (HP:0011422)4.11221147
11Abnormality of small intestinal villus morphology (HP:0011472)3.96033065
12Villous atrophy (HP:0011473)3.96033065
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.86764000
14Conjugated hyperbilirubinemia (HP:0002908)3.73226410
15Flat acetabular roof (HP:0003180)3.72216863
16Gastrointestinal dysmotility (HP:0002579)3.67050683
17Abnormality of the 1st metacarpal (HP:0010009)3.54434868
18Pustule (HP:0200039)3.54372239
19Rectal prolapse (HP:0002035)3.51898776
20Abnormal tarsal ossification (HP:0008369)3.42543181
21Eczematoid dermatitis (HP:0000976)3.42462598
22Pili torti (HP:0003777)3.30230284
23Mildly elevated creatine phosphokinase (HP:0008180)3.28027171
24Micronodular cirrhosis (HP:0001413)3.22258833
25Palpitations (HP:0001962)3.21362937
26Syncope (HP:0001279)3.20513152
27Hemorrhage of the eye (HP:0011885)3.14037092
28Abnormal biliary tract morphology (HP:0012440)3.12848403
29Confusion (HP:0001289)3.10167101
30Pigmentary retinal degeneration (HP:0001146)3.09818885
31Nausea (HP:0002018)3.04237627
32Abnormality of renin-angiotensin system (HP:0000847)2.97127596
33Glomerulonephritis (HP:0000099)2.95826294
34Intrahepatic cholestasis (HP:0001406)2.94695989
35Proximal tubulopathy (HP:0000114)2.93087961
36Woolly hair (HP:0002224)2.90133757
37Dehydration (HP:0001944)2.84613647
38Biliary tract neoplasm (HP:0100574)2.80663929
39Late onset (HP:0003584)2.78960220
40Wide cranial sutures (HP:0010537)2.76545325
41Abnormality of complement system (HP:0005339)2.72301562
42Hydroxyprolinuria (HP:0003080)2.71740847
43Abnormality of proline metabolism (HP:0010907)2.71740847
44Cupped ribs (HP:0000887)2.67633475
45Hyperglycinuria (HP:0003108)2.66368932
46Chronic diarrhea (HP:0002028)2.66282036
47Abnormal foot bone ossification (HP:0010675)2.62159486
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.60043374
49Progressive sensorineural hearing impairment (HP:0000408)2.58374287
50Nephrolithiasis (HP:0000787)2.58308123
51Complement deficiency (HP:0004431)2.57210646
52Milia (HP:0001056)2.56725945
53Hypophosphatemia (HP:0002148)2.53542098
54Nephritis (HP:0000123)2.52049634
55Acanthocytosis (HP:0001927)2.50065103
56Abnormality of the distal phalanx of the thumb (HP:0009617)2.49982081
57Abnormality of the gastric mucosa (HP:0004295)2.49531595
58Fat malabsorption (HP:0002630)2.47235346
59Ventricular arrhythmia (HP:0004308)2.47166365
60Steatorrhea (HP:0002570)2.45226495
61Abnormality of carpal bone ossification (HP:0006257)2.44994676
62Focal segmental glomerulosclerosis (HP:0000097)2.44606133
63Hypobetalipoproteinemia (HP:0003563)2.43312122
64Abnormality of the vitamin B12 metabolism (HP:0004341)2.42863735
65Fragile nails (HP:0001808)2.42709304
66Xanthomatosis (HP:0000991)2.42010038
67Autoimmune thrombocytopenia (HP:0001973)2.40936629
68Increased purine levels (HP:0004368)2.40530823
69Hyperuricemia (HP:0002149)2.40530823
70Cerebral palsy (HP:0100021)2.39778641
71Abnormality of serine family amino acid metabolism (HP:0010894)2.38981964
72Abnormality of glycine metabolism (HP:0010895)2.38981964
73Posterior subcapsular cataract (HP:0007787)2.38657257
74Alkalosis (HP:0001948)2.37628491
75Fragile skin (HP:0001030)2.37485248
76Hypercortisolism (HP:0001578)2.36997526
77Ventricular tachycardia (HP:0004756)2.36701917
78Hyperphosphatemia (HP:0002905)2.35517639
79Hyperparathyroidism (HP:0000843)2.35314920
80Short phalanx of the thumb (HP:0009660)2.34850468
81Thin bony cortex (HP:0002753)2.33974837
82Short 1st metacarpal (HP:0010034)2.33833899
83Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.33833899
84Facial shape deformation (HP:0011334)2.33257284
85Potter facies (HP:0002009)2.33257284
86Hypotension (HP:0002615)2.32712906
87Neoplasm of the rectum (HP:0100743)2.31656311
88Progressive hearing impairment (HP:0001730)2.31335561
89Widely patent fontanelles and sutures (HP:0004492)2.31060186
90Ureteral stenosis (HP:0000071)2.29052145
91Uterine neoplasm (HP:0010784)2.28908750
92Plantar hyperkeratosis (HP:0007556)2.27318767
93Adrenal overactivity (HP:0002717)2.26978221
94Decreased circulating renin level (HP:0003351)2.25674584
95Microretrognathia (HP:0000308)2.25334852
96Abnormality of vitamin B metabolism (HP:0004340)2.24592497
97Growth hormone excess (HP:0000845)2.21101287
98Atrophic scars (HP:0001075)2.20393857
99Neoplasm of the small intestine (HP:0100833)2.17877971
100Gingivitis (HP:0000230)2.17187965
101Hyperaldosteronism (HP:0000859)2.16958916
102Abnormal cartilage morphology (HP:0002763)2.16472826
103Curly hair (HP:0002212)2.16403899
104Cheilitis (HP:0100825)2.14228646
105Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.12501648
106Pancreatitis (HP:0001733)2.10272266
107Enlarged epiphyses (HP:0010580)2.08628499
108Abnormal hair laboratory examination (HP:0003328)2.08295824
109Onycholysis (HP:0001806)2.06990264
110Abnormality of purine metabolism (HP:0004352)2.05849904
111Ureteral obstruction (HP:0006000)2.05532203
112Autoimmune hemolytic anemia (HP:0001890)2.03906532
113Flattened epiphyses (HP:0003071)2.03130530
114Male infertility (HP:0003251)2.03087666
115Hoarse voice (HP:0001609)2.02152400
116Esophageal varix (HP:0002040)2.01524124
117Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00469322
118Dicarboxylic aciduria (HP:0003215)2.00469322
119Abnormality of nucleobase metabolism (HP:0010932)1.99752983
120Ankyloglossia (HP:0010296)1.98481296
121Prolonged QT interval (HP:0001657)1.97776023
122Abnormality of vitamin metabolism (HP:0100508)1.96565771
123Symphalangism affecting the phalanges of the hand (HP:0009773)1.92569922
124Abnormality of the costochondral junction (HP:0000919)1.92408041
125Megaloblastic anemia (HP:0001889)1.92184066
126Glycosuria (HP:0003076)1.92044035
127Abnormality of urine glucose concentration (HP:0011016)1.92044035
128Goiter (HP:0000853)1.91329228
129Glomerulosclerosis (HP:0000096)1.90312342
130Abnormal urine phosphate concentration (HP:0012599)1.89304638
131Protuberant abdomen (HP:0001538)1.89115229
132Petechiae (HP:0000967)1.89095742
133Symptomatic seizures (HP:0011145)1.89091485
134Hypolipoproteinemia (HP:0010981)1.88847219
135Gastrointestinal carcinoma (HP:0002672)1.87400800
136Malignant gastrointestinal tract tumors (HP:0006749)1.87400800
137Abnormal glucose tolerance (HP:0001952)1.86782122
138Abnormality of pyrimidine metabolism (HP:0004353)1.86450612
139Hyperammonemia (HP:0001987)1.85747572
140Delayed epiphyseal ossification (HP:0002663)1.84455457
141Bone pain (HP:0002653)1.84047879
142Premature loss of primary teeth (HP:0006323)1.83571118
143Abnormality of the 2nd finger (HP:0004100)1.83393103
144Multiple lipomas (HP:0001012)1.82809537
145Abnormal ossification of hand bones (HP:0005921)1.82793705
146Hyperphosphaturia (HP:0003109)1.82027228
147Trismus (HP:0000211)1.81425720
148Abnormal hand bone ossification (HP:0010660)1.81086600
149Colitis (HP:0002583)1.80329807
150Abnormality of the nasal mucosa (HP:0000433)1.79432691
151Metabolic acidosis (HP:0001942)1.78817802
152Subcapsular cataract (HP:0000523)1.77039818
153Renal tubular acidosis (HP:0001947)1.76764817
154Segmental peripheral demyelination/remyelination (HP:0003481)1.76295722
155Inflammation of the large intestine (HP:0002037)1.72601628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.32299272
2MST1R5.68887210
3ACVR1B5.64516638
4FRK4.35260015
5PIK3CA4.28479150
6MST44.09434547
7MAP2K23.68418461
8PRKG23.02457750
9MAP3K22.70856647
10NME12.65282249
11TESK12.42101752
12MYLK2.40002867
13RIPK12.34500393
14EPHB22.18862900
15FGFR42.17436111
16KSR22.16265185
17NUAK12.02915261
18MET1.93450966
19TYK21.89608320
20DMPK1.84081146
21EPHA31.79067000
22GRK61.59312103
23MAP2K11.58176473
24PTK61.57316543
25EPHA21.52042829
26MAP4K11.41632825
27MAP2K61.37007725
28PRPF4B1.33119941
29MAP3K101.32792776
30STK241.24998332
31TAOK11.12862348
32FGFR31.12629031
33TAOK31.09614231
34PTK21.03623835
35PKN21.00923303
36LIMK10.99858501
37MAP3K10.98838142
38TNIK0.98552679
39ERBB20.97804250
40MAP3K80.97711885
41PAK40.95924101
42CAMK2D0.93904539
43FER0.88273224
44PRKCI0.87656408
45MAP3K70.83628453
46STK390.83455806
47NLK0.83245821
48PDK20.82333180
49JAK10.81682713
50ERN10.81158568
51STK100.78379452
52RPS6KB20.75560619
53EEF2K0.75013518
54RIPK40.72419622
55WNK40.72136251
56IRAK10.68636974
57BMPR20.67391153
58AKT30.66931336
59DDR20.65718583
60MAP3K110.65522663
61PBK0.63767831
62ZAP700.63253920
63TTK0.60135842
64PDGFRA0.59581304
65MAP3K90.59115343
66MATK0.58624678
67IKBKE0.58524641
68JAK20.58103520
69JAK30.57768105
70MAPK110.57250409
71CAMK2B0.56629183
72EPHB10.55987022
73PRKAA20.55429464
74MAP3K140.54343283
75CAMK2G0.54048866
76ROCK10.53998286
77PAK10.53778937
78PAK20.52972040
79KIT0.52323061
80RAF10.51274854
81MAP3K120.50799518
82LRRK20.50564086
83RET0.48968283
84ABL20.48305604
85YES10.47385543
86STK38L0.47024840
87AURKB0.44983539
88TRIB30.44208716
89TESK20.43986923
90DYRK1B0.41738283
91EPHA40.41623859
92MAP3K30.40152811
93IRAK30.39193946
94PDPK10.38424716
95IRAK40.37879828
96PAK30.37720690
97PRKCZ0.37501744
98TGFBR20.36991056
99PIK3CG0.35900966
100GRK10.35641998
101CDK190.33176318
102OXSR10.33147939
103PRKCA0.32867813
104DAPK30.32701547
105SRC0.32523015
106ITK0.32437308
107PRKAA10.31457365
108TXK0.31194710
109SMG10.31044184
110CSNK1A10.30976183
111LYN0.29822851
112CSF1R0.29205040
113LATS10.28762222
114CDK60.27978791
115PIM20.27748930
116TBK10.27033241
117SYK0.26831682
118CSK0.26478478
119KDR0.26386244
120BMX0.26011217
121PRKCD0.25074437
122MAPKAPK20.24516113
123IGF1R0.24374146
124PDK10.24086413
125BLK0.23802359
126MAPKAPK30.21458246
127SCYL20.20645302
128ILK0.20017029
129ROCK20.20015810
130PDK40.19707051
131PDK30.19707051
132PRKACG0.19190806
133CAMKK10.18927713
134NEK10.18608490
135CSNK1E0.18476629
136TTN0.18423996
137FYN0.18382901
138CDC42BPA0.17760914
139KSR10.17214745
140GSK3A0.16148966
141PRKG10.15858517
142PRKCQ0.14421526
143ERBB40.13062237

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.30335426
2Mineral absorption_Homo sapiens_hsa049784.17035165
3Fat digestion and absorption_Homo sapiens_hsa049753.72650779
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.21945030
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15490001
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.07257290
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60222003
8Bile secretion_Homo sapiens_hsa049762.42492521
9Renin-angiotensin system_Homo sapiens_hsa046142.34724280
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.27737503
11Histidine metabolism_Homo sapiens_hsa003402.24353770
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22992263
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.19296097
14Maturity onset diabetes of the young_Homo sapiens_hsa049502.18442187
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.14177681
16Fructose and mannose metabolism_Homo sapiens_hsa000512.02759297
17Asthma_Homo sapiens_hsa053101.86486817
18Galactose metabolism_Homo sapiens_hsa000521.80579662
19Pancreatic secretion_Homo sapiens_hsa049721.76138022
20Protein digestion and absorption_Homo sapiens_hsa049741.60826734
21Nitrogen metabolism_Homo sapiens_hsa009101.54514029
22Folate biosynthesis_Homo sapiens_hsa007901.54289396
23Vitamin digestion and absorption_Homo sapiens_hsa049771.53526917
24Fatty acid degradation_Homo sapiens_hsa000711.51666569
25Tryptophan metabolism_Homo sapiens_hsa003801.47964272
26Tight junction_Homo sapiens_hsa045301.41307792
27Allograft rejection_Homo sapiens_hsa053301.39978633
28Starch and sucrose metabolism_Homo sapiens_hsa005001.38577473
29Glutathione metabolism_Homo sapiens_hsa004801.33632469
30Autoimmune thyroid disease_Homo sapiens_hsa053201.33616375
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31297351
32Staphylococcus aureus infection_Homo sapiens_hsa051501.28703417
33Glycerolipid metabolism_Homo sapiens_hsa005611.27665772
34Graft-versus-host disease_Homo sapiens_hsa053321.27094172
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.21142234
36Pyruvate metabolism_Homo sapiens_hsa006201.20986215
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19564182
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17237852
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17096293
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17075733
41Arginine and proline metabolism_Homo sapiens_hsa003301.09521634
42Pentose phosphate pathway_Homo sapiens_hsa000301.08348983
43Type I diabetes mellitus_Homo sapiens_hsa049401.04443820
44Caffeine metabolism_Homo sapiens_hsa002321.00840441
45Linoleic acid metabolism_Homo sapiens_hsa005910.95594119
46Thyroid cancer_Homo sapiens_hsa052160.94311374
47Carbon metabolism_Homo sapiens_hsa012000.93114252
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.92340720
49Thyroid hormone synthesis_Homo sapiens_hsa049180.92216890
50Butanoate metabolism_Homo sapiens_hsa006500.90778228
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90767822
52PPAR signaling pathway_Homo sapiens_hsa033200.89219000
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88676815
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86716190
55Antigen processing and presentation_Homo sapiens_hsa046120.83466901
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77979377
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.77916899
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76810421
59Leishmaniasis_Homo sapiens_hsa051400.76691977
60Vibrio cholerae infection_Homo sapiens_hsa051100.76661354
61Salmonella infection_Homo sapiens_hsa051320.75872055
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75153798
63Other glycan degradation_Homo sapiens_hsa005110.74839543
64Oxidative phosphorylation_Homo sapiens_hsa001900.74816418
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73237556
66Gastric acid secretion_Homo sapiens_hsa049710.72951426
67beta-Alanine metabolism_Homo sapiens_hsa004100.72701635
68Chemical carcinogenesis_Homo sapiens_hsa052040.72666171
69Alzheimers disease_Homo sapiens_hsa050100.71287793
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70877900
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.70078738
72Renin secretion_Homo sapiens_hsa049240.67950734
73Arachidonic acid metabolism_Homo sapiens_hsa005900.67393362
74Parkinsons disease_Homo sapiens_hsa050120.67333226
75Bladder cancer_Homo sapiens_hsa052190.67067371
76Salivary secretion_Homo sapiens_hsa049700.66142236
77Sphingolipid metabolism_Homo sapiens_hsa006000.62139288
78Adherens junction_Homo sapiens_hsa045200.61044627
79Hepatitis C_Homo sapiens_hsa051600.59965073
80Arginine biosynthesis_Homo sapiens_hsa002200.58573333
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58563016
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57232033
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57200692
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55552028
85Viral myocarditis_Homo sapiens_hsa054160.54861133
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52024934
87Phenylalanine metabolism_Homo sapiens_hsa003600.51668261
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.47821239
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47565806
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.47029604
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.46138037
92ABC transporters_Homo sapiens_hsa020100.43946009
93Toxoplasmosis_Homo sapiens_hsa051450.43546086
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41782509
95N-Glycan biosynthesis_Homo sapiens_hsa005100.39192796
96Retinol metabolism_Homo sapiens_hsa008300.38660941
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38493016
98Insulin secretion_Homo sapiens_hsa049110.38414909
99Peroxisome_Homo sapiens_hsa041460.38234433
100Metabolic pathways_Homo sapiens_hsa011000.36470210
101Fatty acid metabolism_Homo sapiens_hsa012120.36449565
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35631908
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.35136655
104Ether lipid metabolism_Homo sapiens_hsa005650.33392490
105Hematopoietic cell lineage_Homo sapiens_hsa046400.31850359
106Cardiac muscle contraction_Homo sapiens_hsa042600.31000114
107Fatty acid biosynthesis_Homo sapiens_hsa000610.30201005
108Propanoate metabolism_Homo sapiens_hsa006400.29565359
109Insulin resistance_Homo sapiens_hsa049310.29444901
110Tuberculosis_Homo sapiens_hsa051520.27848688
111Huntingtons disease_Homo sapiens_hsa050160.25659125
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.25270034
113Chemokine signaling pathway_Homo sapiens_hsa040620.23293609
114Biosynthesis of amino acids_Homo sapiens_hsa012300.22758056
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.22656458
116Rheumatoid arthritis_Homo sapiens_hsa053230.20007233
117GnRH signaling pathway_Homo sapiens_hsa049120.19576391
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18584665
119TNF signaling pathway_Homo sapiens_hsa046680.17113369
120Pertussis_Homo sapiens_hsa051330.16876013
121Sulfur relay system_Homo sapiens_hsa041220.15152810
122Endometrial cancer_Homo sapiens_hsa052130.15104215
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12791699
124African trypanosomiasis_Homo sapiens_hsa051430.11967105
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.08805848
126Complement and coagulation cascades_Homo sapiens_hsa046100.08731939
127Tyrosine metabolism_Homo sapiens_hsa003500.08266878
128Influenza A_Homo sapiens_hsa051640.07786310
129Amoebiasis_Homo sapiens_hsa051460.07230463

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