REL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.73367526
2NIK/NF-kappaB signaling (GO:0038061)4.71426028
3antigen processing and presentation of endogenous antigen (GO:0019883)4.69686041
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64627021
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.43094215
6myeloid dendritic cell differentiation (GO:0043011)4.16240128
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02535321
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02535321
9response to muramyl dipeptide (GO:0032495)4.00510359
10* regulation of interleukin-12 biosynthetic process (GO:0045075)3.98821380
11myeloid dendritic cell activation (GO:0001773)3.98452883
12neutrophil activation involved in immune response (GO:0002283)3.95395919
13regulation of alpha-beta T cell proliferation (GO:0046640)3.93954748
14regulation of dendritic cell antigen processing and presentation (GO:0002604)3.91647472
15regulation of B cell receptor signaling pathway (GO:0050855)3.82991990
16cellular response to ethanol (GO:0071361)3.82435327
17negative thymic T cell selection (GO:0045060)3.80138229
18positive regulation of interleukin-2 production (GO:0032743)3.77019712
19positive regulation of alpha-beta T cell proliferation (GO:0046641)3.70738774
20regulation of activation of Janus kinase activity (GO:0010533)3.70253330
21positive regulation by symbiont of host defense response (GO:0052509)3.66354855
22modulation by symbiont of host defense response (GO:0052031)3.66354855
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.66354855
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.66354855
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.66354855
26modulation by symbiont of host immune response (GO:0052553)3.66354855
27positive regulation of antigen processing and presentation (GO:0002579)3.62767039
28positive thymic T cell selection (GO:0045059)3.62678173
29negative T cell selection (GO:0043383)3.62427151
30neutrophil activation (GO:0042119)3.62270260
31defense response to protozoan (GO:0042832)3.61299963
32positive regulation of interferon-alpha production (GO:0032727)3.61152880
33* positive regulation of interleukin-12 production (GO:0032735)3.60836544
34granulocyte activation (GO:0036230)3.59238368
35CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.56276748
36regulation of interferon-alpha production (GO:0032647)3.53904120
37positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.50793625
38negative regulation of interleukin-12 production (GO:0032695)3.49328022
39regulation of gamma-delta T cell activation (GO:0046643)3.47740883
40positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45249456
41histone H3-K4 trimethylation (GO:0080182)3.45140410
42positive regulation of humoral immune response (GO:0002922)3.45096623
43interferon-gamma-mediated signaling pathway (GO:0060333)3.43719889
44immunoglobulin mediated immune response (GO:0016064)3.43642563
45regulation of T cell tolerance induction (GO:0002664)3.40959995
46regulation of gamma-delta T cell differentiation (GO:0045586)3.38327704
47response to peptidoglycan (GO:0032494)3.34955716
48regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.33481070
49positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.31957926
50positive regulation of interleukin-10 production (GO:0032733)3.31832793
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30300991
52regulation of B cell differentiation (GO:0045577)3.29087973
53positive regulation of type 2 immune response (GO:0002830)3.28535651
54monoubiquitinated protein deubiquitination (GO:0035520)3.27927306
55negative regulation of T cell mediated immunity (GO:0002710)3.27796357
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.26597225
57leukocyte aggregation (GO:0070486)3.25335174
58T-helper 1 type immune response (GO:0042088)3.25149564
59regulation of T-helper 1 cell differentiation (GO:0045625)3.24324900
60positive regulation of developmental pigmentation (GO:0048087)3.24242750
61cellular response to interleukin-15 (GO:0071350)3.24129179
62response to protozoan (GO:0001562)3.24001930
63response to type I interferon (GO:0034340)3.23566175
64type I interferon signaling pathway (GO:0060337)3.22591755
65cellular response to type I interferon (GO:0071357)3.22591755
66positive regulation of interleukin-17 production (GO:0032740)3.21593203
67negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.20878278
68negative regulation of cell killing (GO:0031342)3.20878278
69regulation of RIG-I signaling pathway (GO:0039535)3.20693063
70regulation of MHC class I biosynthetic process (GO:0045343)3.18168051
71tolerance induction (GO:0002507)3.17924825
72response to interleukin-15 (GO:0070672)3.17125072
73dendritic cell differentiation (GO:0097028)3.16869625
74regulation of immunoglobulin secretion (GO:0051023)3.16430280
75positive regulation of B cell differentiation (GO:0045579)3.16429423
76regulation of interferon-beta biosynthetic process (GO:0045357)3.16122082
77positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.15578009
78positive regulation of T cell cytokine production (GO:0002726)3.14665179
79regulation of antigen processing and presentation (GO:0002577)3.14603211
80* regulation of interleukin-12 production (GO:0032655)3.14599943
81regulation of interleukin-2 biosynthetic process (GO:0045076)3.13691588
82T cell migration (GO:0072678)3.13445055
83lipopolysaccharide-mediated signaling pathway (GO:0031663)3.12967037
84thymic T cell selection (GO:0045061)3.12449126
85positive regulation of defense response to virus by host (GO:0002230)3.10932487
86interferon-gamma production (GO:0032609)3.10834125
87positive regulation of isotype switching (GO:0045830)3.10743585
88regulation of T-helper cell differentiation (GO:0045622)3.09620482
89regulation of chronic inflammatory response (GO:0002676)3.09085728
90regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.08213687
91positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.08185983
92T-helper cell differentiation (GO:0042093)3.06874057
93CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.06874057
94regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.05862106
95germinal center formation (GO:0002467)3.05411415
96positive regulation of T-helper cell differentiation (GO:0045624)3.05315375
97positive regulation of natural killer cell differentiation (GO:0032825)3.02156875
98mature B cell differentiation (GO:0002335)3.01784939
99natural killer cell mediated cytotoxicity (GO:0042267)3.01023971
100natural killer cell mediated immunity (GO:0002228)3.01023971
101regulation of hypersensitivity (GO:0002883)3.00946960
102positive T cell selection (GO:0043368)3.00451264
103cellular extravasation (GO:0045123)2.99817937
104cellular response to zinc ion (GO:0071294)2.97683278
105regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.96908963
106T cell selection (GO:0045058)2.96839363
107cellular response to exogenous dsRNA (GO:0071360)2.96805743
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.96770048
109B cell receptor signaling pathway (GO:0050853)2.96436369
110interkinetic nuclear migration (GO:0022027)2.94956150
111positive regulation of T-helper 1 type immune response (GO:0002827)2.94210446
112positive regulation of immunoglobulin mediated immune response (GO:0002891)2.92576943
113positive regulation of B cell mediated immunity (GO:0002714)2.92576943
114macrophage activation involved in immune response (GO:0002281)2.90322475
115protein K48-linked deubiquitination (GO:0071108)2.89991849
116regulation of B cell proliferation (GO:0030888)2.89065763
117positive regulation of heat generation (GO:0031652)2.88119212
118regulation of MHC class II biosynthetic process (GO:0045346)2.87118360
119negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.84519685
120regulation of pigment cell differentiation (GO:0050932)2.82039839
121microglial cell activation (GO:0001774)2.80551805
122positive regulation of granulocyte differentiation (GO:0030854)2.79971171
123negative regulation of adaptive immune response (GO:0002820)2.79957404
124indole-containing compound catabolic process (GO:0042436)2.76332165
125indolalkylamine catabolic process (GO:0046218)2.76332165
126tryptophan catabolic process (GO:0006569)2.76332165
127negative regulation of lymphocyte mediated immunity (GO:0002707)2.76257497
128regulation of vitamin D biosynthetic process (GO:0060556)2.75278843
129negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.75066851
130negative regulation of T-helper cell differentiation (GO:0045623)2.75066851
131T cell differentiation involved in immune response (GO:0002292)2.73855291
132alpha-beta T cell differentiation involved in immune response (GO:0002293)2.73855291
133alpha-beta T cell activation involved in immune response (GO:0002287)2.73855291
134alpha-beta T cell differentiation (GO:0046632)2.73358851
135establishment of protein localization to Golgi (GO:0072600)2.73207937
136B cell proliferation (GO:0042100)2.73072965
137positive regulation of B cell proliferation (GO:0030890)2.70450185
138regulation of germinal center formation (GO:0002634)2.67790058
139B cell homeostasis (GO:0001782)2.67548122
140phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66590007
141regulation of establishment of cell polarity (GO:2000114)2.65899272
142hepatocyte apoptotic process (GO:0097284)2.65503987
143activated T cell proliferation (GO:0050798)2.65195765
144alpha-beta T cell activation (GO:0046631)2.64143828
145protein K63-linked deubiquitination (GO:0070536)2.63660099
146negative regulation of B cell proliferation (GO:0030889)2.61763720
147CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.61741162
148positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.61622837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.73631293
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.47426415
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.33134800
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.85623366
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.50759583
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.20399434
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.97668005
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.77131522
9* IRF8_27001747_Chip-Seq_BMDM_Mouse3.75842144
10* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.55609102
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.41813586
12* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.17485977
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15492935
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14696940
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.96364986
16RUNX_20019798_ChIP-Seq_JUKART_Human2.85847779
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.85483044
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83199793
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65595087
20FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61697311
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.53050659
22MYB_26560356_Chip-Seq_TH2_Human2.43659416
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.38374301
24MAF_26560356_Chip-Seq_TH1_Human2.10800620
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.01822049
26MYB_26560356_Chip-Seq_TH1_Human2.01080613
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.96793117
28SPI1_23547873_ChIP-Seq_NB4_Human1.90629888
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88773220
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.88220014
31SCL_19346495_ChIP-Seq_HPC-7_Human1.87148176
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.86127466
33* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83642564
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79434136
35VDR_24763502_ChIP-Seq_THP-1_Human1.78608243
36VDR_24787735_ChIP-Seq_THP-1_Human1.71480466
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.68327545
38* PU_27001747_Chip-Seq_BMDM_Mouse1.66435370
39MYC_22102868_ChIP-Seq_BL_Human1.63124375
40VDR_21846776_ChIP-Seq_THP-1_Human1.61491979
41VDR_22108803_ChIP-Seq_LS180_Human1.59829724
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.57215834
43PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57116015
44GATA3_27048872_Chip-Seq_THYMUS_Human1.55205482
45TP53_16413492_ChIP-PET_HCT116_Human1.53746641
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52063785
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50627130
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50290345
49ER_23166858_ChIP-Seq_MCF-7_Human1.45809669
50SPI1_23127762_ChIP-Seq_K562_Human1.45763457
51TCF7_22412390_ChIP-Seq_EML_Mouse1.45735839
52GBX2_23144817_ChIP-Seq_PC3_Human1.45695648
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45680729
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41599611
55UTX_26944678_Chip-Seq_JUKART_Human1.35690724
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35552603
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35375103
58GATA3_26560356_Chip-Seq_TH2_Human1.35092416
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35039215
60ZNF274_21170338_ChIP-Seq_K562_Hela1.34860374
61STAT3_23295773_ChIP-Seq_U87_Human1.34635773
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34093961
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33908331
64POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33908331
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31214067
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31192293
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28991633
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.28458728
69AR_21572438_ChIP-Seq_LNCaP_Human1.28130457
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27861727
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25674951
72SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24648308
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24480446
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23978601
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23356341
76GATA1_22025678_ChIP-Seq_K562_Human1.20783780
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18739138
78TAF15_26573619_Chip-Seq_HEK293_Human1.17444737
79AHR_22903824_ChIP-Seq_MCF-7_Human1.16924578
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16898749
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15565573
82* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15352319
83MAF_26560356_Chip-Seq_TH2_Human1.14684271
84TCF4_23295773_ChIP-Seq_U87_Human1.13336098
85* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10763521
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10709189
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10304214
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06717470
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.05277744
90GATA2_21666600_ChIP-Seq_HMVEC_Human1.04774625
91* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03999344
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02792787
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02420442
94* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02116128
95BCAT_22108803_ChIP-Seq_LS180_Human1.02004257
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.01822744
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01419419
98LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00593083
99* FLI1_21867929_ChIP-Seq_TH2_Mouse1.00232221
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00032071
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99927807
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.99534221
103EWS_26573619_Chip-Seq_HEK293_Human0.98790640
104P300_19829295_ChIP-Seq_ESCs_Human0.97753161
105CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97724145
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96902709
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96902709
108KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96769457
109CBP_20019798_ChIP-Seq_JUKART_Human0.96728084
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96728084
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95809224
112KDM2B_26808549_Chip-Seq_DND41_Human0.94587971
113IGF1R_20145208_ChIP-Seq_DFB_Human0.93844256
114SMAD4_21799915_ChIP-Seq_A2780_Human0.93055532
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92687775
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92664481
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92489086
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92184075
119SMRT_27268052_Chip-Seq_Bcells_Human0.91500158
120TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90782499
121SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90647346
122* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.90460298
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.89128310
124EGR1_19032775_ChIP-ChIP_M12_Human0.88815369
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87506562
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86862433
127KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86612839
128DROSHA_22980978_ChIP-Seq_HELA_Human0.85923669
129THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85435079
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.85316491
131* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84175528
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.83881749
133LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.82242088
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80585865
135FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78207785
136TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77519207
137CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75868639
138ELK3_25401928_ChIP-Seq_HUVEC_Human0.75682572
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72582183
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69447762
141* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67750819
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66067981
143GATA1_19941827_ChIP-Seq_MEL_Mouse0.65697240
144CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.65297635
145GATA2_19941826_ChIP-Seq_K562_Human0.64183906
146SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.63908292
147GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63147456
148* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.62723205
149IKZF1_21737484_ChIP-ChIP_HCT116_Human0.61246304
150CJUN_26792858_Chip-Seq_BT549_Human0.60726775
151SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59139788
152* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57757465
153KDM2B_26808549_Chip-Seq_JURKAT_Human0.54690538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.01743415
2MP0000685_abnormal_immune_system3.56969089
3MP0005671_abnormal_response_to3.53723965
4MP0001790_abnormal_immune_system3.48862993
5MP0005387_immune_system_phenotype3.48862993
6MP0002148_abnormal_hypersensitivity_rea3.41089755
7MP0003436_decreased_susceptibility_to3.37811433
8MP0009785_altered_susceptibility_to3.36125042
9* MP0005000_abnormal_immune_tolerance3.26423499
10MP0001800_abnormal_humoral_immune3.24477386
11MP0003303_peritoneal_inflammation3.20778152
12MP0004510_myositis2.94396815
13* MP0002452_abnormal_antigen_presenting2.92460446
14* MP0002723_abnormal_immune_serum2.80795655
15MP0002419_abnormal_innate_immunity2.67749521
16* MP0005025_abnormal_response_to2.67690486
17MP0002138_abnormal_hepatobiliary_system2.67063617
18MP0001853_heart_inflammation2.58826721
19* MP0001819_abnormal_immune_cell2.54224381
20* MP0002420_abnormal_adaptive_immunity2.52919638
21MP0002166_altered_tumor_susceptibility2.33195857
22MP0003195_calcinosis2.31187492
23MP0002006_tumorigenesis2.29540706
24MP0003763_abnormal_thymus_physiology2.27930016
25MP0006082_CNS_inflammation2.26752904
26MP0002405_respiratory_system_inflammati2.23953600
27MP0003724_increased_susceptibility_to2.15787902
28MP0004947_skin_inflammation2.11848543
29MP0002398_abnormal_bone_marrow2.04451173
30* MP0000716_abnormal_immune_system1.97922935
31MP0003300_gastrointestinal_ulcer1.93431756
32MP0010155_abnormal_intestine_physiology1.91078489
33MP0005310_abnormal_salivary_gland1.87363572
34MP0002254_reproductive_system_inflammat1.80822214
35MP0003646_muscle_fatigue1.80069925
36MP0001845_abnormal_inflammatory_respons1.78495357
37MP0001873_stomach_inflammation1.77061174
38MP0000569_abnormal_digit_pigmentation1.65939821
39MP0005464_abnormal_platelet_physiology1.64605913
40* MP0000689_abnormal_spleen_morphology1.58405059
41MP0009333_abnormal_splenocyte_physiolog1.58047007
42MP0001533_abnormal_skeleton_physiology1.56649225
43MP0002429_abnormal_blood_cell1.56435820
44MP0002722_abnormal_immune_system1.53985527
45MP0009764_decreased_sensitivity_to1.51260078
46MP0008961_abnormal_basal_metabolism1.44420298
47MP0003448_altered_tumor_morphology1.41440132
48MP0001501_abnormal_sleep_pattern1.38698890
49MP0005076_abnormal_cell_differentiation1.35419150
50MP0008469_abnormal_protein_level1.32974909
51MP0001348_abnormal_lacrimal_gland1.31459171
52MP0002396_abnormal_hematopoietic_system1.28450561
53MP0005167_abnormal_blood-brain_barrier1.27219697
54MP0001545_abnormal_hematopoietic_system1.24355264
55MP0005397_hematopoietic_system_phenotyp1.24355264
56MP0000703_abnormal_thymus_morphology1.23761445
57MP0002933_joint_inflammation1.20069981
58MP0003866_abnormal_defecation1.19454508
59MP0009278_abnormal_bone_marrow1.19419779
60MP0002009_preneoplasia1.19324287
61MP0003453_abnormal_keratinocyte_physiol1.17426159
62MP0002998_abnormal_bone_remodeling1.14966452
63MP0002277_abnormal_respiratory_mucosa1.14663083
64MP0004808_abnormal_hematopoietic_stem1.14626300
65MP0010352_gastrointestinal_tract_polyps1.11733953
66MP0000858_altered_metastatic_potential1.11608083
67MP0003828_pulmonary_edema1.07027777
68MP0001851_eye_inflammation1.06354368
69MP0000383_abnormal_hair_follicle1.01467087
70MP0002163_abnormal_gland_morphology1.01274872
71MP0009115_abnormal_fat_cell0.99529453
72MP0002332_abnormal_exercise_endurance0.96394956
73MP0005075_abnormal_melanosome_morpholog0.95831540
74MP0000015_abnormal_ear_pigmentation0.94359079
75MP0000465_gastrointestinal_hemorrhage0.94312869
76MP0003091_abnormal_cell_migration0.91664935
77MP0004043_abnormal_pH_regulation0.90793329
78MP0003252_abnormal_bile_duct0.88964876
79MP0002168_other_aberrant_phenotype0.88712582
80MP0005174_abnormal_tail_pigmentation0.88292618
81MP0000427_abnormal_hair_cycle0.86787518
82MP0003191_abnormal_cellular_cholesterol0.85286856
83MP0002693_abnormal_pancreas_physiology0.83957835
84MP0005647_abnormal_sex_gland0.83785600
85MP0000343_altered_response_to0.83247762
86MP0000604_amyloidosis0.82320492
87MP0008877_abnormal_DNA_methylation0.81656957
88MP0003045_fibrosis0.80239727
89MP0000490_abnormal_crypts_of0.79789355
90MP0004130_abnormal_muscle_cell0.78980004
91MP0003172_abnormal_lysosome_physiology0.78728414
92MP0005058_abnormal_lysosome_morphology0.77427750
93MP0002877_abnormal_melanocyte_morpholog0.76239012
94MP0009763_increased_sensitivity_to0.75797387
95* MP0008057_abnormal_DNA_replication0.75543189
96MP0003075_altered_response_to0.74746014
97MP0004883_abnormal_blood_vessel0.74212747
98MP0010307_abnormal_tumor_latency0.73970821
99MP0000249_abnormal_blood_vessel0.73580477
100MP0003656_abnormal_erythrocyte_physiolo0.72641962
101MP0005645_abnormal_hypothalamus_physiol0.71761122
102MP0003787_abnormal_imprinting0.70649699
103MP0004742_abnormal_vestibular_system0.70643042
104MP0008872_abnormal_physiological_respon0.70380446
105MP0003566_abnormal_cell_adhesion0.68582316
106* MP0005390_skeleton_phenotype0.68574373
107MP0008004_abnormal_stomach_pH0.66858172
108MP0005166_decreased_susceptibility_to0.66127610
109MP0002136_abnormal_kidney_physiology0.64680195
110MP0001346_abnormal_lacrimal_gland0.64317004
111MP0003183_abnormal_peptide_metabolism0.64264056
112MP0000627_abnormal_mammary_gland0.62840657
113MP0004782_abnormal_surfactant_physiolog0.62544432
114MP0010234_abnormal_vibrissa_follicle0.61763215
115MP0001663_abnormal_digestive_system0.60167324
116MP0002019_abnormal_tumor_incidence0.59821663
117MP0000371_diluted_coat_color0.59641877
118* MP0001216_abnormal_epidermal_layer0.59209856
119MP0005448_abnormal_energy_balance0.58788427
120MP0001986_abnormal_taste_sensitivity0.58217298
121MP0009765_abnormal_xenobiotic_induced0.57990520
122MP0004142_abnormal_muscle_tone0.57161701
123MP0003795_abnormal_bone_structure0.57026837
124MP0001881_abnormal_mammary_gland0.56519995
125MP0000767_abnormal_smooth_muscle0.56312952
126MP0005164_abnormal_response_to0.54775050
127MP0004381_abnormal_hair_follicle0.53987262
128MP0002928_abnormal_bile_duct0.52085691
129MP0001191_abnormal_skin_condition0.51904005

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.97508187
2Recurrent abscess formation (HP:0002722)5.48393968
3Recurrent bacterial skin infections (HP:0005406)5.27116508
4Retrobulbar optic neuritis (HP:0100654)5.08504510
5Optic neuritis (HP:0100653)5.08504510
6Stomatitis (HP:0010280)4.85756144
7Mediastinal lymphadenopathy (HP:0100721)4.78873615
8Orchitis (HP:0100796)4.70846334
9Myositis (HP:0100614)4.60094969
10Elevated erythrocyte sedimentation rate (HP:0003565)4.58848996
11Recurrent fungal infections (HP:0002841)4.52089759
12Vasculitis (HP:0002633)4.23767699
13Genetic anticipation (HP:0003743)4.14095709
14Recurrent viral infections (HP:0004429)4.10557401
15Gastrointestinal infarctions (HP:0005244)4.01822077
16Recurrent skin infections (HP:0001581)3.80699850
17Chronic mucocutaneous candidiasis (HP:0002728)3.75742342
18Recurrent cutaneous fungal infections (HP:0011370)3.75742342
19Pulmonary infiltrates (HP:0002113)3.75563185
20Recurrent gram-negative bacterial infections (HP:0005420)3.74079841
21Agammaglobulinemia (HP:0004432)3.56732526
22Arterial thrombosis (HP:0004420)3.49103707
23Abnormality of macrophages (HP:0004311)3.44753870
24Increased IgM level (HP:0003496)3.42751156
25Abnormality of T cell number (HP:0011839)3.37931796
26Autoimmune thrombocytopenia (HP:0001973)3.37394440
27Chronic otitis media (HP:0000389)3.36555796
28Meningitis (HP:0001287)3.34843040
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.26885605
30Obstructive lung disease (HP:0006536)3.24578159
31Chronic obstructive pulmonary disease (HP:0006510)3.24578159
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.24110008
33T lymphocytopenia (HP:0005403)3.16118340
34Keratoconjunctivitis sicca (HP:0001097)3.15802677
35Gingivitis (HP:0000230)3.14534349
36Cellulitis (HP:0100658)3.14316659
37Clumsiness (HP:0002312)3.13532288
38Increased neuronal autofluorescent lipopigment (HP:0002074)3.13447240
39Recurrent bronchitis (HP:0002837)3.12766565
40Colitis (HP:0002583)3.02745149
41Hemoptysis (HP:0002105)3.00964091
42Periodontitis (HP:0000704)3.00656817
43Panhypogammaglobulinemia (HP:0003139)3.00012358
44Keratoconjunctivitis (HP:0001096)2.93387921
45Gastrointestinal stroma tumor (HP:0100723)2.91306891
46Leukocytosis (HP:0001974)2.91134243
47Stomach cancer (HP:0012126)2.89942805
48Myocardial infarction (HP:0001658)2.87271273
49Inflammation of the large intestine (HP:0002037)2.86806484
50Hyperventilation (HP:0002883)2.84565873
51Increased cerebral lipofuscin (HP:0011813)2.80454797
52Progressive cerebellar ataxia (HP:0002073)2.78271094
53Pustule (HP:0200039)2.77920559
54Abnormality of T cells (HP:0002843)2.76430972
55Protruding tongue (HP:0010808)2.76217910
56Chronic diarrhea (HP:0002028)2.73449302
57Gaze-evoked nystagmus (HP:0000640)2.72690089
58Abnormality of the fingertips (HP:0001211)2.72288197
59Thyroiditis (HP:0100646)2.71008893
60Eosinophilia (HP:0001880)2.67942219
61IgA deficiency (HP:0002720)2.67460428
62Recurrent pneumonia (HP:0006532)2.65129719
63Gastrointestinal inflammation (HP:0004386)2.64791774
64Fair hair (HP:0002286)2.63886988
65Lymphopenia (HP:0001888)2.58294863
66Abnormality of cells of the lymphoid lineage (HP:0012140)2.57667732
67Osteomyelitis (HP:0002754)2.57357239
68IgG deficiency (HP:0004315)2.56846352
69Chest pain (HP:0100749)2.53953967
70Encephalitis (HP:0002383)2.52661266
71Hematochezia (HP:0002573)2.52466989
72Nasal polyposis (HP:0100582)2.52219617
73Hypergammaglobulinemia (HP:0010702)2.52204341
74Gingival bleeding (HP:0000225)2.51352934
75Gangrene (HP:0100758)2.48650443
76IgM deficiency (HP:0002850)2.46430573
77Increased IgE level (HP:0003212)2.45999799
78Severe combined immunodeficiency (HP:0004430)2.45708294
79Abnormality of eosinophils (HP:0001879)2.44379733
80Thick nail (HP:0001805)2.44096360
81Abnormality of T cell physiology (HP:0011840)2.43724299
82Thrombocytosis (HP:0001894)2.42832751
83Basal ganglia calcification (HP:0002135)2.42058128
84Interstitial pulmonary disease (HP:0006530)2.42009714
85Dysmetric saccades (HP:0000641)2.41977001
86Autoimmune hemolytic anemia (HP:0001890)2.40863036
87Prostate neoplasm (HP:0100787)2.40238967
88Recurrent lower respiratory tract infections (HP:0002783)2.38792216
89Widely spaced teeth (HP:0000687)2.37996181
90Pancreatic cysts (HP:0001737)2.37720001
91Emphysema (HP:0002097)2.36602075
92Chronic hepatic failure (HP:0100626)2.33038225
93Anhidrosis (HP:0000970)2.32698835
94Recurrent sinusitis (HP:0011108)2.31893345
95Generalized hypopigmentation of hair (HP:0011358)2.31510994
96Abnormality of the prostate (HP:0008775)2.30850683
97B lymphocytopenia (HP:0010976)2.30108667
98Abnormality of B cell number (HP:0010975)2.30108667
99Neoplasm of the tracheobronchial system (HP:0100552)2.28501160
100Combined immunodeficiency (HP:0005387)2.25227576
101Anorexia (HP:0002039)2.24500014
102Granulocytopenia (HP:0001913)2.22778001
103Arthralgia (HP:0002829)2.20452342
104Amaurosis fugax (HP:0100576)2.18575236
105Spontaneous hematomas (HP:0007420)2.17343976
106Osteolytic defects of the phalanges of the hand (HP:0009771)2.15072377
107Osteolytic defects of the hand bones (HP:0009699)2.15072377
108Viral hepatitis (HP:0006562)2.14355453
109Attenuation of retinal blood vessels (HP:0007843)2.14287716
110Joint swelling (HP:0001386)2.13762041
111Alveolar cell carcinoma (HP:0006519)2.11570459
112Skin ulcer (HP:0200042)2.10005232
113Abnormality of the nasal mucosa (HP:0000433)2.08865798
114Premature loss of primary teeth (HP:0006323)2.08061677
115Urticaria (HP:0001025)2.04587541
116Restrictive lung disease (HP:0002091)2.03260358
117Fatigue (HP:0012378)2.02237777
118Vacuolated lymphocytes (HP:0001922)2.02171542
119Sepsis (HP:0100806)2.00817365
120Pulmonary embolism (HP:0002204)1.99868029
121Acute myeloid leukemia (HP:0004808)1.99709579
122Congenital stationary night blindness (HP:0007642)1.96369974
123Abnormality of the pleura (HP:0002103)1.91544957
124Bronchitis (HP:0012387)1.90110188
125Abnormality of the renal cortex (HP:0011035)1.86415967
126Abnormality of binocular vision (HP:0011514)1.84368698
127Diplopia (HP:0000651)1.84368698
128Febrile seizures (HP:0002373)1.83488134
129Acute lymphatic leukemia (HP:0006721)1.79706017
130Hypoplasia of the thymus (HP:0000778)1.77445486
131Lymphoma (HP:0002665)1.73924296
132Prominent nose (HP:0000448)1.73723397
133Facial diplegia (HP:0001349)1.67156969
134Progressive inability to walk (HP:0002505)1.66178712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.40194493
2MAP3K145.47351611
3MAP4K13.94510528
4TXK3.07595272
5TBK13.00222289
6JAK32.99969074
7TYK22.95857288
8* IKBKB2.85929130
9IRAK32.84045650
10RIPK42.80129379
11IKBKE2.77460946
12IRAK42.65593280
13ACVR1B2.39167176
14BLK2.34032277
15MAP3K132.29467604
16JAK12.22904118
17* CHUK2.10859060
18ZAP701.73976726
19MST41.67699651
20KIT1.66732397
21PIM21.63262207
22STK101.62123283
23BMPR1B1.59632107
24SIK31.59418962
25AKT31.59005768
26SYK1.56818088
27CAMK1D1.54193278
28ITK1.53659257
29ADRBK21.52192098
30PIM11.50386158
31TEC1.46572894
32BTK1.45554435
33FGFR31.42786042
34CSK1.41864227
35TGFBR21.41847102
36BMPR21.40293775
37CSF1R1.39730900
38PIK3CG1.39008299
39HCK1.35922242
40FGFR41.32317989
41EPHB11.32182962
42EPHA31.26969311
43LCK1.23768278
44SGK21.21260505
45CDK121.20084937
46CAMK1G1.12846385
47NEK91.08942753
48RPS6KA41.08460953
49MAP2K31.07661475
50NLK1.05882682
51PRPF4B1.03638068
52LYN1.01779521
53JAK21.01411921
54TAOK30.99691930
55MARK30.96220439
56IRAK10.94390328
57MAP3K30.94383983
58GRK60.93503066
59CAMKK20.93077622
60MKNK20.92063082
61EIF2AK20.91726405
62MAP3K100.86593203
63TNK20.86514112
64PRKCQ0.83859538
65ERN10.80529315
66STK240.79729915
67SIK20.79087523
68WNK10.78147537
69LRRK20.77356163
70CDC42BPA0.76713668
71MAP3K70.75459877
72INSRR0.73896911
73TGFBR10.71600400
74SGK30.71492426
75PRKAA20.64435892
76MAPK110.61482489
77CLK10.61354174
78MAPKAPK20.60344910
79STK40.60200425
80DAPK20.59592211
81TRPM70.59566888
82NUAK10.59540453
83ABL10.59346078
84FES0.59277341
85GRK70.56155532
86MAP3K50.55847245
87ADRBK10.55259148
88OXSR10.52913719
89MATK0.52185175
90RPS6KA50.52007440
91CAMK40.51069459
92STK30.50343379
93SGK4940.50275343
94SGK2230.50275343
95EGFR0.48112799
96GRK10.46145135
97MAPK120.45912826
98PTK2B0.45411227
99FGR0.45322022
100PBK0.45206584
101PKN10.45083679
102BMX0.44428776
103MARK20.44187147
104TAOK20.43334635
105MAP2K60.42873649
106NME20.42359564
107PRKCD0.42292232
108MAP3K110.41953923
109SGK10.41046946
110RIPK10.40840946
111PDGFRB0.40299010
112RPS6KA60.39140538
113YES10.37856466
114CDK60.37752794
115STK38L0.37226834
116TNIK0.36996730
117PRKCH0.36684751
118CDK90.36011240
119FLT30.34647080
120IRAK20.31618900
121RPS6KA10.30785985
122INSR0.29295180
123MELK0.28827304
124MAP3K10.28649944
125BRD40.27773371
126ALK0.26506409
127TAOK10.24808285
128DMPK0.24802879
129HIPK20.24574096
130MAPK70.24244026
131IGF1R0.23997292
132GSK3A0.23966753
133MOS0.23480564
134CDK40.21093065
135PIK3CA0.20693504
136PDK10.20618482
137EIF2AK30.20417950

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.52165605
2Graft-versus-host disease_Homo sapiens_hsa053323.37187163
3NF-kappa B signaling pathway_Homo sapiens_hsa040643.14691506
4Leishmaniasis_Homo sapiens_hsa051403.01611345
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77071010
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.70638257
7Primary immunodeficiency_Homo sapiens_hsa053402.54889691
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.45099071
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.40695866
10Osteoclast differentiation_Homo sapiens_hsa043802.40147822
11Measles_Homo sapiens_hsa051622.34963490
12B cell receptor signaling pathway_Homo sapiens_hsa046622.24522354
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.21373717
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13554604
15Type I diabetes mellitus_Homo sapiens_hsa049402.11523630
16Autoimmune thyroid disease_Homo sapiens_hsa053202.05824934
17Legionellosis_Homo sapiens_hsa051342.01071682
18TNF signaling pathway_Homo sapiens_hsa046682.00033293
19T cell receptor signaling pathway_Homo sapiens_hsa046601.87575468
20Asthma_Homo sapiens_hsa053101.86160158
21Toxoplasmosis_Homo sapiens_hsa051451.78482694
22Hematopoietic cell lineage_Homo sapiens_hsa046401.76045097
23Pertussis_Homo sapiens_hsa051331.75060667
24Influenza A_Homo sapiens_hsa051641.74364879
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.73283652
26Herpes simplex infection_Homo sapiens_hsa051681.71611069
27Malaria_Homo sapiens_hsa051441.67624371
28Tuberculosis_Homo sapiens_hsa051521.67601613
29Antigen processing and presentation_Homo sapiens_hsa046121.66286828
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60846056
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54252768
32Staphylococcus aureus infection_Homo sapiens_hsa051501.52633825
33Chemokine signaling pathway_Homo sapiens_hsa040621.49726761
34Rheumatoid arthritis_Homo sapiens_hsa053231.47524147
35African trypanosomiasis_Homo sapiens_hsa051431.45996618
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44759408
37Apoptosis_Homo sapiens_hsa042101.42605149
38Viral myocarditis_Homo sapiens_hsa054161.38486581
39Hepatitis B_Homo sapiens_hsa051611.26003281
40Shigellosis_Homo sapiens_hsa051311.23845286
41Salmonella infection_Homo sapiens_hsa051321.20424721
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.16956916
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10084699
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.08898116
45Acute myeloid leukemia_Homo sapiens_hsa052211.06801787
46ABC transporters_Homo sapiens_hsa020101.01482352
47Hepatitis C_Homo sapiens_hsa051601.01349103
48Chronic myeloid leukemia_Homo sapiens_hsa052200.97032737
49Prolactin signaling pathway_Homo sapiens_hsa049170.95377037
50Epstein-Barr virus infection_Homo sapiens_hsa051690.92444650
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.87862486
52* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87121450
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82246979
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79945613
55Small cell lung cancer_Homo sapiens_hsa052220.76942590
56Linoleic acid metabolism_Homo sapiens_hsa005910.73912578
57Pancreatic cancer_Homo sapiens_hsa052120.73594247
58HTLV-I infection_Homo sapiens_hsa051660.71895404
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.71730226
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71231220
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.67145035
62Platelet activation_Homo sapiens_hsa046110.61985664
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61164122
64Phagosome_Homo sapiens_hsa041450.60828222
65Amoebiasis_Homo sapiens_hsa051460.60657452
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58711502
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58512828
68* Viral carcinogenesis_Homo sapiens_hsa052030.56717574
69Lysosome_Homo sapiens_hsa041420.55280733
70Ether lipid metabolism_Homo sapiens_hsa005650.51034000
71MicroRNAs in cancer_Homo sapiens_hsa052060.50889192
72Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50280200
73MAPK signaling pathway_Homo sapiens_hsa040100.50269948
74Circadian rhythm_Homo sapiens_hsa047100.50058578
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49908432
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47906096
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47421079
78Ovarian steroidogenesis_Homo sapiens_hsa049130.47115714
79Phototransduction_Homo sapiens_hsa047440.47069114
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47068481
81Lysine degradation_Homo sapiens_hsa003100.46579452
82Choline metabolism in cancer_Homo sapiens_hsa052310.45838313
83p53 signaling pathway_Homo sapiens_hsa041150.44907037
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42963250
85FoxO signaling pathway_Homo sapiens_hsa040680.41947698
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.41908722
87Type II diabetes mellitus_Homo sapiens_hsa049300.41234685
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.40338757
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.39657880
90Other glycan degradation_Homo sapiens_hsa005110.39408508
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.36921620
92Insulin resistance_Homo sapiens_hsa049310.36685831
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35915061
94HIF-1 signaling pathway_Homo sapiens_hsa040660.35703024
95GnRH signaling pathway_Homo sapiens_hsa049120.35638672
96VEGF signaling pathway_Homo sapiens_hsa043700.35547020
97Oxytocin signaling pathway_Homo sapiens_hsa049210.34574067
98Olfactory transduction_Homo sapiens_hsa047400.33608916
99Long-term depression_Homo sapiens_hsa047300.33594093
100Calcium signaling pathway_Homo sapiens_hsa040200.33542075
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33523907
102Prostate cancer_Homo sapiens_hsa052150.33308174
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31998856
104Dorso-ventral axis formation_Homo sapiens_hsa043200.31501557
105Notch signaling pathway_Homo sapiens_hsa043300.31498926
106Nitrogen metabolism_Homo sapiens_hsa009100.31480314
107Proteoglycans in cancer_Homo sapiens_hsa052050.30284178
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29825613
109cAMP signaling pathway_Homo sapiens_hsa040240.29373336
110Inositol phosphate metabolism_Homo sapiens_hsa005620.25152978
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25032809
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22857387
113Non-small cell lung cancer_Homo sapiens_hsa052230.21910568
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21488036
115Pathways in cancer_Homo sapiens_hsa052000.21330210
116Endocytosis_Homo sapiens_hsa041440.20534063
117Prion diseases_Homo sapiens_hsa050200.19219226
118Renal cell carcinoma_Homo sapiens_hsa052110.18299695
119Colorectal cancer_Homo sapiens_hsa052100.16811578
120Adherens junction_Homo sapiens_hsa045200.16293647
121ErbB signaling pathway_Homo sapiens_hsa040120.16236295
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12187158
123mTOR signaling pathway_Homo sapiens_hsa041500.11033539
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.09515066
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.07892307

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