RELA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte migration involved in inflammatory response (GO:0002523)7.56076780
2positive regulation of astrocyte differentiation (GO:0048711)6.12746766
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.61570562
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.61570562
5leukocyte tethering or rolling (GO:0050901)5.27434157
6antigen processing and presentation of endogenous antigen (GO:0019883)5.24297743
7positive regulation of gamma-delta T cell activation (GO:0046645)4.74698407
8positive regulation of DNA recombination (GO:0045911)4.59719850
9histone H3-K36 demethylation (GO:0070544)4.20511799
10regulation of isotype switching (GO:0045191)4.11998712
11COPI coating of Golgi vesicle (GO:0048205)4.01539992
12Golgi transport vesicle coating (GO:0048200)4.01539992
13regulation of gamma-delta T cell differentiation (GO:0045586)3.98184918
14NIK/NF-kappaB signaling (GO:0038061)3.92759396
15nuclear pore complex assembly (GO:0051292)3.89914500
16regulation of gamma-delta T cell activation (GO:0046643)3.83799860
17* regulation of interleukin-12 biosynthetic process (GO:0045075)3.73964339
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69604420
19positive regulation of Cdc42 GTPase activity (GO:0043089)3.65113999
20regulation of RNA export from nucleus (GO:0046831)3.62701335
21urinary tract smooth muscle contraction (GO:0014848)3.59847906
22regulation of nucleobase-containing compound transport (GO:0032239)3.56199772
23regulation of vitamin D biosynthetic process (GO:0060556)3.49843002
24response to type I interferon (GO:0034340)3.39591505
253-UTR-mediated mRNA stabilization (GO:0070935)3.38784283
26type I interferon signaling pathway (GO:0060337)3.37252837
27cellular response to type I interferon (GO:0071357)3.37252837
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.34788633
29activation of MAPKKK activity (GO:0000185)3.30709878
30positive regulation by symbiont of host defense response (GO:0052509)3.28363762
31modulation by symbiont of host defense response (GO:0052031)3.28363762
32modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28363762
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28363762
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.28363762
35modulation by symbiont of host immune response (GO:0052553)3.28363762
36positive regulation of interferon-alpha production (GO:0032727)3.27297959
37immunoglobulin mediated immune response (GO:0016064)3.26507396
38nuclear pore organization (GO:0006999)3.26097599
39positive thymic T cell selection (GO:0045059)3.25308169
40leukocyte aggregation (GO:0070486)3.22651037
41positive regulation of natural killer cell differentiation (GO:0032825)3.22424916
42JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.17645410
43pore complex assembly (GO:0046931)3.17001069
44DNA unwinding involved in DNA replication (GO:0006268)3.14518039
45positive regulation of immunoglobulin production (GO:0002639)3.13230489
46regulation of interferon-alpha production (GO:0032647)3.11895108
47negative thymic T cell selection (GO:0045060)3.10941231
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.08585792
49myeloid dendritic cell differentiation (GO:0043011)3.05933805
50regulation of NFAT protein import into nucleus (GO:0051532)3.05691871
51negative regulation of homotypic cell-cell adhesion (GO:0034111)3.05629431
52positive regulation of protein kinase C signaling (GO:0090037)3.05619525
53myeloid dendritic cell activation (GO:0001773)3.05572648
54positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05255132
55neutrophil activation involved in immune response (GO:0002283)3.05028221
56positive regulation of B cell differentiation (GO:0045579)3.04142663
57positive regulation of receptor internalization (GO:0002092)3.03978691
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.02094407
59peristalsis (GO:0030432)3.01218711
60regulation of vitamin metabolic process (GO:0030656)3.01173038
61negative T cell selection (GO:0043383)2.99318263
62activation of Rac GTPase activity (GO:0032863)2.97342655
63positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.95791424
64* response to muramyl dipeptide (GO:0032495)2.95688698
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.95389216
66interferon-gamma-mediated signaling pathway (GO:0060333)2.93664525
67regulation of B cell receptor signaling pathway (GO:0050855)2.92206603
68cellular hyperosmotic response (GO:0071474)2.90541765
69regulation of response to interferon-gamma (GO:0060330)2.90125417
70* membrane protein intracellular domain proteolysis (GO:0031293)2.83971932
71negative regulation of interleukin-12 production (GO:0032695)2.83806803
72regulation of interferon-beta biosynthetic process (GO:0045357)2.83037810
73response to peptidoglycan (GO:0032494)2.82951557
74mannose metabolic process (GO:0006013)2.81755296
75tolerance induction (GO:0002507)2.81506180
76positive regulation of humoral immune response (GO:0002922)2.81448802
77regulation of glucose import in response to insulin stimulus (GO:2001273)2.80948000
78adhesion of symbiont to host cell (GO:0044650)2.80823309
79virion attachment to host cell (GO:0019062)2.80823309
80histone lysine demethylation (GO:0070076)2.79022917
81regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.78662973
82antigen processing and presentation via MHC class Ib (GO:0002475)2.78130594
83regulation of B cell differentiation (GO:0045577)2.77406561
84positive regulation of B cell proliferation (GO:0030890)2.77059465
85Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76728559
86regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.76447893
87thymic T cell selection (GO:0045061)2.74445052
88binding of sperm to zona pellucida (GO:0007339)2.74031306
89T cell migration (GO:0072678)2.73962984
90retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.73661015
91response to protozoan (GO:0001562)2.71688663
92histone demethylation (GO:0016577)2.71620229
93negative regulation of erythrocyte differentiation (GO:0045647)2.70837610
94protein localization to endosome (GO:0036010)2.68655967
95negative regulation of necroptotic process (GO:0060546)2.68369140
96regulation of mammary gland epithelial cell proliferation (GO:0033599)2.65281015
97cellular response to zinc ion (GO:0071294)2.64778554
98leukocyte cell-cell adhesion (GO:0007159)2.63858248
99natural killer cell differentiation (GO:0001779)2.63451665
100positive regulation of antigen processing and presentation (GO:0002579)2.62448892
101B cell mediated immunity (GO:0019724)2.62067287
102regulation of early endosome to late endosome transport (GO:2000641)2.61928196
103adhesion of symbiont to host (GO:0044406)2.61817342
104dosage compensation (GO:0007549)2.61683893
105positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.60855272
106defense response to protozoan (GO:0042832)2.60553728
107negative regulation of viral release from host cell (GO:1902187)2.60381434
108positive regulation of isotype switching (GO:0045830)2.60237294
109response to interferon-alpha (GO:0035455)2.59970060
110regulation of immunoglobulin production (GO:0002637)2.59430772
111lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58567280
112macrophage activation involved in immune response (GO:0002281)2.56222919
113histone H2A monoubiquitination (GO:0035518)2.55843768
114mRNA stabilization (GO:0048255)2.55038531
115RNA stabilization (GO:0043489)2.55038531
116positive regulation of interferon-beta production (GO:0032728)2.52411637
117positive regulation of B cell mediated immunity (GO:0002714)2.49620216
118positive regulation of immunoglobulin mediated immune response (GO:0002891)2.49620216
119response to interferon-beta (GO:0035456)2.49407646
120negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.49170081
121dendritic cell differentiation (GO:0097028)2.49086673
122neutrophil activation (GO:0042119)2.48742571
123granulocyte activation (GO:0036230)2.48303723
124positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.47561185
125interferon-gamma production (GO:0032609)2.47302155
126modulation by symbiont of host cellular process (GO:0044068)2.46606721
127regulation of T cell tolerance induction (GO:0002664)2.45934899
128response to laminar fluid shear stress (GO:0034616)2.45256680
129necroptotic process (GO:0070266)2.45138935
130protein dealkylation (GO:0008214)2.45077577
131protein demethylation (GO:0006482)2.45077577
132cellular response to virus (GO:0098586)2.45068660
133mitotic chromosome condensation (GO:0007076)2.43040516
134positive regulation of interleukin-2 production (GO:0032743)2.43027871
135histone monoubiquitination (GO:0010390)2.42963671
136germinal center formation (GO:0002467)2.42780085
137regulation of immunoglobulin mediated immune response (GO:0002889)2.42540897
138response to interleukin-15 (GO:0070672)2.42502792
139positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.42358784
140pinocytosis (GO:0006907)2.41910449
141* TRIF-dependent toll-like receptor signaling pathway (GO:0035666)2.40717745
142growth hormone receptor signaling pathway (GO:0060396)2.40410453
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.40260010
144T cell selection (GO:0045058)2.40054948
145proline biosynthetic process (GO:0006561)2.39964433
146respiratory burst (GO:0045730)2.39110878
147regulation of B cell mediated immunity (GO:0002712)2.38647458
148* toll-like receptor 3 signaling pathway (GO:0034138)2.38451248
149amyloid precursor protein catabolic process (GO:0042987)2.37829802
150negative regulation of cell size (GO:0045792)2.37561992
151regulation of alpha-beta T cell proliferation (GO:0046640)2.36796378
152positive regulation of odontogenesis (GO:0042482)2.36213802
153regulation of cholesterol storage (GO:0010885)2.35189108
154* cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.34748723
155regulation of response to osmotic stress (GO:0047484)2.33660525
156positive regulation of blood vessel endothelial cell migration (GO:0043536)2.33646441
157* MyD88-independent toll-like receptor signaling pathway (GO:0002756)2.32691910
158B cell receptor signaling pathway (GO:0050853)2.32523829
159negative regulation of phagocytosis (GO:0050765)2.32373377
160regulation of natural killer cell differentiation (GO:0032823)2.32350179
161hepatocyte apoptotic process (GO:0097284)2.31261220
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.30977487
163cellular response to interferon-beta (GO:0035458)2.30409418
164T cell apoptotic process (GO:0070231)2.29744053
165regulation of antigen processing and presentation (GO:0002577)2.29486311
166regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.29383865
167negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.29281837
168* positive regulation of cytokine biosynthetic process (GO:0042108)2.28754518
169regulation of necroptotic process (GO:0060544)2.28204343
170low-density lipoprotein particle clearance (GO:0034383)2.28111706
171negative regulation of skeletal muscle tissue development (GO:0048642)2.27582049
172regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.27398665
173regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.26259577
174regulation of T-helper 2 cell differentiation (GO:0045628)2.26178057
175natural killer cell mediated cytotoxicity (GO:0042267)2.26172804
176natural killer cell mediated immunity (GO:0002228)2.26172804

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.62670775
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.70189342
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.38195383
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.33336861
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.27488551
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04711512
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.98552837
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89931585
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88235601
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65207012
11MYC_22102868_ChIP-Seq_BL_Human2.54430807
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48036755
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.47383884
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43854273
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.41975582
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.39315977
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38277371
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.26235229
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21313163
20VDR_21846776_ChIP-Seq_THP-1_Human2.19721852
21SCL_19346495_ChIP-Seq_HPC-7_Human2.16809341
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.15312645
23* MAF_26560356_Chip-Seq_TH1_Human2.15293736
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.05495786
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.99533482
26* MYB_26560356_Chip-Seq_TH2_Human1.96219594
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92532598
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.90966187
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.90721740
30RUNX_20019798_ChIP-Seq_JUKART_Human1.84102844
31FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.83527237
32VDR_24763502_ChIP-Seq_THP-1_Human1.82335497
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.80253214
34TCF7_22412390_ChIP-Seq_EML_Mouse1.76910528
35* MYB_26560356_Chip-Seq_TH1_Human1.75621117
36SPI1_23547873_ChIP-Seq_NB4_Human1.73533379
37* UTX_26944678_Chip-Seq_JUKART_Human1.72799536
38* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.72027034
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69828149
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.68920606
41E2F7_22180533_ChIP-Seq_HELA_Human1.68919368
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63153728
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54249095
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54155116
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53172101
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52247097
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51587725
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50839165
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.49922035
50KDM2B_26808549_Chip-Seq_K562_Human1.44385333
51* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43525216
52STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40647859
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40312410
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.38946337
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38851237
56* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38272579
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37008640
58MAF_26560356_Chip-Seq_TH2_Human1.36866600
59* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36278322
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35840696
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.34513220
62SPI1_23127762_ChIP-Seq_K562_Human1.34378830
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.33889822
64CLOCK_20551151_ChIP-Seq_293T_Human1.32830363
65* KDM2B_26808549_Chip-Seq_JURKAT_Human1.30862568
66CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30846953
67* KDM2B_26808549_Chip-Seq_DND41_Human1.30081300
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28892086
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28826846
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28235485
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27434434
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26093828
73ESR2_21235772_ChIP-Seq_MCF-7_Human1.21597426
74* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20901015
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20723754
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20515602
77* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19446003
78GATA1_22025678_ChIP-Seq_K562_Human1.19091962
79* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18795227
80* XRN2_22483619_ChIP-Seq_HELA_Human1.18660907
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18565583
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18227305
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18094546
84PU_27001747_Chip-Seq_BMDM_Mouse1.17992026
85* P68_20966046_ChIP-Seq_HELA_Human1.17781875
86GATA3_27048872_Chip-Seq_THYMUS_Human1.16953328
87* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16300558
88* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15288995
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15021114
90LXR_22158963_ChIP-Seq_LIVER_Mouse1.14533311
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14386640
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13375005
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12545396
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.11999633
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11480940
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11147606
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.10645406
98GATA2_21666600_ChIP-Seq_HMVEC_Human1.09147744
99* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08506181
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06685293
101UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05424853
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05375558
103* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05307623
104LXR_22292898_ChIP-Seq_THP-1_Human1.04946666
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02958571
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02848851
107* TET1_21451524_ChIP-Seq_MESCs_Mouse1.02693804
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02353835
109MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02181704
110* NCOR1_26117541_ChIP-Seq_K562_Human1.02006064
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01510830
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01343411
113ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99625179
114CREB1_26743006_Chip-Seq_LNCaP_Human0.99366912
115* BCOR_27268052_Chip-Seq_Bcells_Human0.99215876
116RACK7_27058665_Chip-Seq_MCF-7_Human0.99111461
117HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96539580
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96216537
119ATF3_27146783_Chip-Seq_COLON_Human0.94891118
120ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93756310
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93430329
122MYC_18555785_ChIP-Seq_MESCs_Mouse0.93273075
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.92120388
124ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91978454
125* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91942237
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.91041638
127SMC4_20622854_ChIP-Seq_HELA_Human0.90087919
128SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89813709
129UBF1/2_26484160_Chip-Seq_HMECs_Human0.89384046
130LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88976753
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88717010
132MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88629748
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88579849
134CIITA_25753668_ChIP-Seq_RAJI_Human0.88531831
135* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88041909
136* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87896316
137TFEB_21752829_ChIP-Seq_HELA_Human0.87706350
138SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87420031
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87420031
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86446476
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85589908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.33490547
2MP0003436_decreased_susceptibility_to3.16612653
3MP0000685_abnormal_immune_system2.99501996
4MP0009785_altered_susceptibility_to2.68959638
5MP0003303_peritoneal_inflammation2.64523803
6MP0001790_abnormal_immune_system2.57526774
7MP0005387_immune_system_phenotype2.57526774
8MP0005000_abnormal_immune_tolerance2.40394295
9* MP0001800_abnormal_humoral_immune2.35466906
10MP0005451_abnormal_body_composition2.31446098
11MP0003724_increased_susceptibility_to2.29090109
12MP0005671_abnormal_response_to2.28763075
13MP0005025_abnormal_response_to2.25509053
14* MP0002452_abnormal_antigen_presenting2.21060386
15MP0003763_abnormal_thymus_physiology2.17677558
16MP0002419_abnormal_innate_immunity2.17534942
17MP0002148_abnormal_hypersensitivity_rea2.14821114
18MP0003300_gastrointestinal_ulcer2.14628651
19* MP0002723_abnormal_immune_serum2.13201088
20MP0006082_CNS_inflammation2.11383993
21MP0008260_abnormal_autophagy2.01061749
22* MP0002420_abnormal_adaptive_immunity1.97114745
23* MP0001819_abnormal_immune_cell1.96716414
24MP0009278_abnormal_bone_marrow1.90788478
25* MP0002405_respiratory_system_inflammati1.89299414
26MP0004947_skin_inflammation1.89069974
27MP0004858_abnormal_nervous_system1.87315733
28MP0004233_abnormal_muscle_weight1.84717398
29MP0005464_abnormal_platelet_physiology1.82498134
30MP0002166_altered_tumor_susceptibility1.77100002
31MP0001533_abnormal_skeleton_physiology1.75480994
32* MP0002398_abnormal_bone_marrow1.74327187
33MP0001545_abnormal_hematopoietic_system1.72760006
34MP0005397_hematopoietic_system_phenotyp1.72760006
35* MP0001853_heart_inflammation1.72505231
36* MP0010155_abnormal_intestine_physiology1.72128369
37MP0009333_abnormal_splenocyte_physiolog1.71890760
38MP0009840_abnormal_foam_cell1.68205953
39MP0003705_abnormal_hypodermis_morpholog1.64695537
40* MP0000716_abnormal_immune_system1.63651629
41MP0002396_abnormal_hematopoietic_system1.62650733
42* MP0001845_abnormal_inflammatory_respons1.60874671
43MP0002138_abnormal_hepatobiliary_system1.60461226
44MP0002006_tumorigenesis1.52532247
45MP0002933_joint_inflammation1.52098650
46* MP0000689_abnormal_spleen_morphology1.51995509
47* MP0004510_myositis1.51701718
48MP0001873_stomach_inflammation1.49350248
49MP0004808_abnormal_hematopoietic_stem1.49227628
50MP0003191_abnormal_cellular_cholesterol1.48857244
51MP0010352_gastrointestinal_tract_polyps1.46880435
52MP0002722_abnormal_immune_system1.46740280
53MP0000858_altered_metastatic_potential1.44110314
54* MP0002429_abnormal_blood_cell1.41338965
55MP0003566_abnormal_cell_adhesion1.38891196
56MP0008469_abnormal_protein_level1.37525784
57MP0000343_altered_response_to1.36601174
58MP0005023_abnormal_wound_healing1.36493524
59MP0000678_abnormal_parathyroid_gland1.35677196
60MP0003448_altered_tumor_morphology1.35224837
61MP0005058_abnormal_lysosome_morphology1.28367123
62MP0001849_ear_inflammation1.27971971
63MP0008438_abnormal_cutaneous_collagen1.27583322
64MP0005666_abnormal_adipose_tissue1.25625230
65MP0005375_adipose_tissue_phenotype1.23164106
66MP0009764_decreased_sensitivity_to1.21331510
67MP0000465_gastrointestinal_hemorrhage1.19057954
68MP0003111_abnormal_nucleus_morphology1.16810890
69MP0000350_abnormal_cell_proliferation1.15204988
70MP0003279_aneurysm1.15124443
71MP0000003_abnormal_adipose_tissue1.14646802
72* MP0000703_abnormal_thymus_morphology1.14481954
73MP0003453_abnormal_keratinocyte_physiol1.13306261
74MP0002998_abnormal_bone_remodeling1.12019910
75MP0005076_abnormal_cell_differentiation1.11671916
76MP0005623_abnormal_meninges_morphology1.08395017
77MP0004185_abnormal_adipocyte_glucose1.07738651
78MP0006054_spinal_hemorrhage1.04768630
79MP0010234_abnormal_vibrissa_follicle1.03882499
80MP0002009_preneoplasia1.03801735
81MP0003091_abnormal_cell_migration1.03297609
82MP0010368_abnormal_lymphatic_system1.02666970
83MP0010094_abnormal_chromosome_stability1.02382324
84MP0001851_eye_inflammation1.01687527
85MP0005310_abnormal_salivary_gland1.01526623
86MP0005390_skeleton_phenotype1.00133218
87MP0002254_reproductive_system_inflammat0.99242407
88MP0003077_abnormal_cell_cycle0.99092503
89MP0005621_abnormal_cell_physiology0.97972085
90* MP0000490_abnormal_crypts_of0.93268589
91* MP0000609_abnormal_liver_physiology0.92396593
92MP0001730_embryonic_growth_arrest0.91064195
93* MP0000313_abnormal_cell_death0.90484390
94* MP0009763_increased_sensitivity_to0.89515168
95MP0000249_abnormal_blood_vessel0.86063330
96MP0003693_abnormal_embryo_hatching0.85799081
97MP0001958_emphysema0.85613925
98* MP0003866_abnormal_defecation0.84033621
99MP0003828_pulmonary_edema0.83513818
100MP0003656_abnormal_erythrocyte_physiolo0.83136315
101MP0000604_amyloidosis0.82685016
102MP0003690_abnormal_glial_cell0.82445475
103MP0000767_abnormal_smooth_muscle0.82118672
104MP0002019_abnormal_tumor_incidence0.81112352
105* MP0000733_abnormal_muscle_development0.81034088
106MP0003186_abnormal_redox_activity0.80870452
107MP0002249_abnormal_larynx_morphology0.80862381
108MP0002089_abnormal_postnatal_growth/wei0.79506716
109MP0002132_abnormal_respiratory_system0.78616483
110MP0001243_abnormal_dermal_layer0.78215638
111MP0008057_abnormal_DNA_replication0.77733408
112* MP0000598_abnormal_liver_morphology0.77217550
113MP0001348_abnormal_lacrimal_gland0.77143110
114MP0002332_abnormal_exercise_endurance0.76943542
115MP0005166_decreased_susceptibility_to0.75727021
116MP0005670_abnormal_white_adipose0.75280010
117MP0001915_intracranial_hemorrhage0.74230331
118MP0003329_amyloid_beta_deposits0.73786944
119MP0001879_abnormal_lymphatic_vessel0.73648055
120* MP0003795_abnormal_bone_structure0.73412146
121MP0003075_altered_response_to0.73009276
122MP0002136_abnormal_kidney_physiology0.72873934
123MP0002877_abnormal_melanocyte_morpholog0.72214548
124MP0010307_abnormal_tumor_latency0.72147676
125MP0003172_abnormal_lysosome_physiology0.70976283
126MP0004782_abnormal_surfactant_physiolog0.66356056
127MP0005360_urolithiasis0.65684135
128MP0005319_abnormal_enzyme/_coenzyme0.64242439
129MP0008007_abnormal_cellular_replicative0.63673177
130* MP0001216_abnormal_epidermal_layer0.61819907
131MP0005164_abnormal_response_to0.61117166
132MP0009931_abnormal_skin_appearance0.61078298

Predicted human phenotypes

RankGene SetZ-score
1Thoracolumbar scoliosis (HP:0002944)5.32508320
2Eczematoid dermatitis (HP:0000976)4.75904093
3Elevated erythrocyte sedimentation rate (HP:0003565)4.58960722
4Dry hair (HP:0011359)4.47561495
5Recurrent abscess formation (HP:0002722)4.03169580
6Cubitus valgus (HP:0002967)3.90829255
7Recurrent bacterial skin infections (HP:0005406)3.80184213
8Myositis (HP:0100614)3.69445614
9Autoimmune thrombocytopenia (HP:0001973)3.54586261
10Chronic otitis media (HP:0000389)3.48718276
11Recurrent gram-negative bacterial infections (HP:0005420)3.44525348
12Recurrent fungal infections (HP:0002841)3.44040200
13Recurrent viral infections (HP:0004429)3.27330761
14Abnormality of the nasal mucosa (HP:0000433)3.22834563
15Nasal polyposis (HP:0100582)3.22077739
16Limited elbow extension (HP:0001377)3.19276690
17Sensorimotor neuropathy (HP:0007141)3.18382974
18Orchitis (HP:0100796)3.13391473
19Stomatitis (HP:0010280)3.10668819
20Interstitial pulmonary disease (HP:0006530)3.06629572
21Recurrent bronchitis (HP:0002837)3.02558859
22Mediastinal lymphadenopathy (HP:0100721)2.94074159
23Cellulitis (HP:0100658)2.92149395
24Recurrent skin infections (HP:0001581)2.91091957
25Pustule (HP:0200039)2.89488212
26Vasculitis (HP:0002633)2.87528594
27Malignant hyperthermia (HP:0002047)2.84385818
28Abnormality of macrophages (HP:0004311)2.80902093
29Systemic lupus erythematosus (HP:0002725)2.77377288
30Distal lower limb muscle weakness (HP:0009053)2.75602135
31Thrombocytosis (HP:0001894)2.74749396
32Myocardial infarction (HP:0001658)2.71464673
33Spontaneous hematomas (HP:0007420)2.67071520
34Abnormal delayed hypersensitivity skin test (HP:0002963)2.64889002
35Lumbar hyperlordosis (HP:0002938)2.61681013
36Colitis (HP:0002583)2.61160604
37Peritonitis (HP:0002586)2.60824462
38Disproportionate tall stature (HP:0001519)2.59367325
39Vertebral compression fractures (HP:0002953)2.57533091
40Abnormality of T cell number (HP:0011839)2.56260917
41Optic neuritis (HP:0100653)2.55461505
42Retrobulbar optic neuritis (HP:0100654)2.55461505
43Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.53427090
44Absent epiphyses (HP:0010577)2.53427090
45Abnormality of T cell physiology (HP:0011840)2.53106782
46Abnormality of T cells (HP:0002843)2.52957804
47Recurrent cutaneous fungal infections (HP:0011370)2.51535976
48Chronic mucocutaneous candidiasis (HP:0002728)2.51535976
49IgM deficiency (HP:0002850)2.49941032
50Ulnar bowing (HP:0003031)2.48555471
51Inflammation of the large intestine (HP:0002037)2.48177508
52Gastrointestinal inflammation (HP:0004386)2.47117189
53Petechiae (HP:0000967)2.44749185
54Arterial thrombosis (HP:0004420)2.43797008
55Tinnitus (HP:0000360)2.42759672
56T lymphocytopenia (HP:0005403)2.41985549
57Abnormality of the phalanges of the hallux (HP:0010057)2.41882380
58Vacuolated lymphocytes (HP:0001922)2.38889276
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.37568462
60Gingival bleeding (HP:0000225)2.37432691
61Gastrointestinal infarctions (HP:0005244)2.34110086
62Hypotrichosis (HP:0001006)2.33491764
63Periodontitis (HP:0000704)2.32860347
64Premature skin wrinkling (HP:0100678)2.32684665
65Emphysema (HP:0002097)2.32079693
66Hematochezia (HP:0002573)2.31597733
67Epistaxis (HP:0000421)2.30865659
68Leukocytosis (HP:0001974)2.30268731
692-3 toe syndactyly (HP:0004691)2.28631473
70Panhypogammaglobulinemia (HP:0003139)2.28562136
71Coarse hair (HP:0002208)2.28063507
72Protruding ear (HP:0000411)2.26722408
73Pulmonary infiltrates (HP:0002113)2.26646403
74Meningitis (HP:0001287)2.26512477
75Segmental peripheral demyelination/remyelination (HP:0003481)2.26386624
76Osteolytic defects of the hand bones (HP:0009699)2.25886179
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.25886179
78Gingivitis (HP:0000230)2.24984408
79Increased density of long bones (HP:0006392)2.24413983
80Septate vagina (HP:0001153)2.20033081
81Gastrointestinal stroma tumor (HP:0100723)2.19336047
82Impaired platelet aggregation (HP:0003540)2.17077538
83Abnormal platelet function (HP:0011869)2.17077538
84Hyperacusis (HP:0010780)2.16547868
85Agammaglobulinemia (HP:0004432)2.16484213
86Distal lower limb amyotrophy (HP:0008944)2.16237691
87Increased IgE level (HP:0003212)2.14724054
88Prolonged bleeding time (HP:0003010)2.14191428
89Axonal loss (HP:0003447)2.13780312
90Osteomyelitis (HP:0002754)2.13532186
91Polycythemia (HP:0001901)2.12882443
92Woolly hair (HP:0002224)2.11574156
93Hypergammaglobulinemia (HP:0010702)2.10856634
94Protrusio acetabuli (HP:0003179)2.09854261
95Joint swelling (HP:0001386)2.07854574
96Esophageal varix (HP:0002040)2.07491457
97Urticaria (HP:0001025)2.07182321
98Fatigue (HP:0012378)2.06989796
99Abnormality of the fingertips (HP:0001211)2.06199525
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.06149300
101Abnormality of the distal phalanges of the toes (HP:0010182)2.04651172
102Lymphopenia (HP:0001888)2.03729512
103IgA deficiency (HP:0002720)1.98795862
104Increased IgM level (HP:0003496)1.98566447
105Subacute progressive viral hepatitis (HP:0006572)1.98314201
106Abnormal umbilical cord blood vessels (HP:0011403)1.98140842
107Single umbilical artery (HP:0001195)1.98140842
108Abnormality of the fetal cardiovascular system (HP:0010948)1.98140842
109Increased cerebral lipofuscin (HP:0011813)1.96565864
110Glossoptosis (HP:0000162)1.96425913
111Hemoptysis (HP:0002105)1.96399855
112Skin ulcer (HP:0200042)1.96120971
113Aortic aneurysm (HP:0004942)1.92598440
114Long palpebral fissure (HP:0000637)1.92560409
115Dysmetric saccades (HP:0000641)1.92226684
116Keratoconjunctivitis sicca (HP:0001097)1.91721379
117Urethral obstruction (HP:0000796)1.91219302
118Chronic diarrhea (HP:0002028)1.89934027
119Eosinophilia (HP:0001880)1.89631882
120Increased connective tissue (HP:0009025)1.88515130
121Upper motor neuron abnormality (HP:0002127)1.88507131
122Abnormal platelet volume (HP:0011876)1.88482298
123Dysostosis multiplex (HP:0000943)1.88246922
124Persistence of primary teeth (HP:0006335)1.87155409
125Long eyelashes (HP:0000527)1.86362300
126Increased serum ferritin (HP:0003281)1.85682081
127Loss of speech (HP:0002371)1.85044393
128Arthralgia (HP:0002829)1.84753035
129Basal ganglia calcification (HP:0002135)1.84000604
130Abnormality of hair growth rate (HP:0011363)1.83920858
131Slow-growing hair (HP:0002217)1.83920858
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.82728857
133Obstructive lung disease (HP:0006536)1.82594706
134Chronic obstructive pulmonary disease (HP:0006510)1.82594706
135Tetraparesis (HP:0002273)1.80688301
136Bell-shaped thorax (HP:0001591)1.80075220
137Polygenic inheritance (HP:0010982)1.79399549
138Glomerulonephritis (HP:0000099)1.79339069
139Hyperparathyroidism (HP:0000843)1.78798267
140Cerebral aneurysm (HP:0004944)1.78645667
141Purpura (HP:0000979)1.77863270
142Biconcave vertebral bodies (HP:0004586)1.77710163
143Chest pain (HP:0100749)1.77369606
144Autoimmune hemolytic anemia (HP:0001890)1.76835749
145Hypoplastic ischia (HP:0003175)1.76511713
146Aneurysm (HP:0002617)1.75784637
147Protuberant abdomen (HP:0001538)1.75502044
148Enlarged epiphyses (HP:0010580)1.74557672
149Nephritis (HP:0000123)1.74488810
150Broad face (HP:0000283)1.74194001
151Abnormality of the umbilical cord (HP:0010881)1.72742115
152Spondylolisthesis (HP:0003302)1.72333431
153Bilateral sensorineural hearing impairment (HP:0008619)1.69654362
154Upper limb muscle weakness (HP:0003484)1.69435740
155Atelectasis (HP:0100750)1.68392315
156Deep palmar crease (HP:0006191)1.67619118
157Slow saccadic eye movements (HP:0000514)1.66014958
158Trismus (HP:0000211)1.65823227
159Achilles tendon contracture (HP:0001771)1.65746759
160Upper limb amyotrophy (HP:0009129)1.64823141
161Distal upper limb amyotrophy (HP:0007149)1.64823141
162Camptodactyly of toe (HP:0001836)1.63122931
163Thin bony cortex (HP:0002753)1.62406203
164Hypertensive crisis (HP:0100735)1.61593744
165Flat acetabular roof (HP:0003180)1.60318630
166Mitral regurgitation (HP:0001653)1.60007891
167Hyporeflexia of lower limbs (HP:0002600)1.58270965
168Frequent falls (HP:0002359)1.56565091
169Premature rupture of membranes (HP:0001788)1.56328153
170Cerebral inclusion bodies (HP:0100314)1.56235587
171Deviation of the thumb (HP:0009603)1.54701476
172Camptodactyly of finger (HP:0100490)1.54404990
173Viral hepatitis (HP:0006562)1.53350358
174Difficulty climbing stairs (HP:0003551)1.52961197
175Mitral valve prolapse (HP:0001634)1.51878453
176Abnormality of liposaccharide metabolism (HP:0010968)1.50781415
177Abnormality of glycosphingolipid metabolism (HP:0004343)1.50781415
178Abnormality of glycolipid metabolism (HP:0010969)1.50781415
179Increased variability in muscle fiber diameter (HP:0003557)1.50239049
180Abnormality of the thoracic spine (HP:0100711)1.49756839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.64335581
2MAP4K14.07515834
3DDR23.80436922
4MAP3K143.12444662
5ERN13.12175315
6TYK22.79093102
7JAK32.69914169
8TRIB32.69496367
9ICK2.66797687
10* TBK12.57228594
11PRPF4B2.48505504
12TXK2.38259997
13ZAP702.04840195
14KIT2.01295105
15FGFR42.00653145
16IRAK31.95900049
17PIM21.93335248
18EPHB11.89537642
19EEF2K1.87852002
20MAP2K31.85560320
21MAP3K101.83416728
22* IKBKB1.82465263
23STK101.81538947
24BLK1.80474621
25* IKBKE1.76356740
26TGFBR21.73491934
27JAK11.68036704
28BRD41.66989183
29MAP3K31.66572254
30PKN21.60181192
31IRAK41.59485070
32NME21.54760968
33* CHUK1.51899055
34BTK1.51161550
35LRRK21.35732244
36KDR1.30366219
37PTK61.29630772
38CSK1.27005768
39ITK1.25829458
40EPHA31.22841196
41VRK21.19107725
42TEC1.17082062
43KSR21.14664502
44MAP3K111.14598752
45TAF11.14588368
46CSF1R1.14165395
47ARAF1.13493232
48TAOK31.12803666
49TTN1.11236492
50NLK1.08411594
51FLT31.07802151
52SIK11.07694395
53HCK1.06887250
54SYK1.03657840
55LCK1.01617023
56* PIM11.01271002
57NEK91.00375721
58EPHA20.99598503
59TAOK10.99179808
60CDK120.92599960
61MAP3K130.89735529
62IRAK20.89066106
63GRK60.87740716
64CDK90.87576502
65PRKD20.86475451
66JAK20.85656858
67MST40.84019066
68CDC42BPA0.82036548
69FGFR30.82007731
70PDGFRA0.81332150
71* RPS6KA40.80753858
72MOS0.80233182
73RIPK40.79317183
74MARK30.79284071
75CDK70.79278031
76TGFBR10.78215329
77PAK40.74549296
78CSNK1A1L0.74005373
79CLK10.71266165
80CDK40.70657712
81LYN0.70505042
82TRPM70.70211834
83BMX0.69783065
84CDK60.66253704
85RIPK10.65860899
86MARK20.64782563
87STK40.60794100
88MAPKAPK20.60616781
89CSNK1G30.60049479
90TYRO30.57895924
91MAP3K80.57673644
92MATK0.56519148
93BRAF0.55923439
94SIK20.54961561
95MELK0.54777982
96TAOK20.54239049
97TESK10.53873181
98PDPK10.53704771
99MAP3K90.53662631
100SIK30.51665184
101RPS6KC10.50138551
102RPS6KL10.50138551
103CHEK10.49439754
104STK30.48194740
105CHEK20.47927590
106MAP3K70.47414353
107STK240.44923524
108PRKG20.43130867
109MAP3K10.42586982
110MAP3K60.42364275
111TIE10.41731290
112STK380.41708942
113MAPKAPK50.41059756
114ABL10.40901914
115EGFR0.40649690
116TESK20.39253007
117PDGFRB0.39139481
118BCKDK0.38606196
119PIK3CG0.38566197
120CAMK1G0.38443195
121RPS6KB20.38314836
122PDK10.37082431
123DYRK30.35987075
124MAPK110.35785416
125PAK20.35682393
126PBK0.35057610
127AKT20.34097059
128DYRK1B0.33663316
129IRAK10.33391579
130CAMK1D0.33341223
131RPS6KA10.33296929
132EIF2AK20.33256085
133MAP3K50.33220078
134HIPK20.32941112
135MAP2K20.32918229
136MTOR0.32618549
137* RPS6KA60.32580895
138MAPK40.31014557
139ABL20.30993563
140ALK0.29204192
141DAPK10.28272057
142MAPK70.27272484
143CDK20.26170643
144RPS6KA20.25730007

Predicted pathways (KEGG)

RankGene SetZ-score
1* Leishmaniasis_Homo sapiens_hsa051402.74274233
2* NF-kappa B signaling pathway_Homo sapiens_hsa040642.69544735
3Primary immunodeficiency_Homo sapiens_hsa053402.42290166
4* Osteoclast differentiation_Homo sapiens_hsa043802.30667806
5* Measles_Homo sapiens_hsa051622.29957284
6Staphylococcus aureus infection_Homo sapiens_hsa051502.27322461
7* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.14051966
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.04755445
9* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98039401
10* Legionellosis_Homo sapiens_hsa051341.97344756
11* B cell receptor signaling pathway_Homo sapiens_hsa046621.90344348
12Allograft rejection_Homo sapiens_hsa053301.89204975
13Antigen processing and presentation_Homo sapiens_hsa046121.88288969
14Malaria_Homo sapiens_hsa051441.86943761
15* TNF signaling pathway_Homo sapiens_hsa046681.86885764
16* Toxoplasmosis_Homo sapiens_hsa051451.84985152
17Graft-versus-host disease_Homo sapiens_hsa053321.82344321
18* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.77250859
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.66842773
20* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66754153
21* Herpes simplex infection_Homo sapiens_hsa051681.65490105
22* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64322262
23* Influenza A_Homo sapiens_hsa051641.63017626
24Hematopoietic cell lineage_Homo sapiens_hsa046401.61284880
25* Pertussis_Homo sapiens_hsa051331.55739047
26* Apoptosis_Homo sapiens_hsa042101.48957450
27Asthma_Homo sapiens_hsa053101.45967548
28* T cell receptor signaling pathway_Homo sapiens_hsa046601.43145208
29* Shigellosis_Homo sapiens_hsa051311.39950693
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38295488
31* Tuberculosis_Homo sapiens_hsa051521.35296035
32* Acute myeloid leukemia_Homo sapiens_hsa052211.35271341
33Viral myocarditis_Homo sapiens_hsa054161.33197325
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29444220
35* Hepatitis B_Homo sapiens_hsa051611.28413877
36* Longevity regulating pathway - mammal_Homo sapiens_hsa042111.26959807
37* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25119956
38* Chronic myeloid leukemia_Homo sapiens_hsa052201.23317004
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.23067232
40* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19662216
41* Small cell lung cancer_Homo sapiens_hsa052221.12187893
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12100779
43Thyroid cancer_Homo sapiens_hsa052161.09722477
44Caffeine metabolism_Homo sapiens_hsa002321.08709259
45mTOR signaling pathway_Homo sapiens_hsa041501.08446717
46Complement and coagulation cascades_Homo sapiens_hsa046101.05794953
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05623513
48* Hepatitis C_Homo sapiens_hsa051601.01755980
49Other glycan degradation_Homo sapiens_hsa005111.00077572
50* Chemokine signaling pathway_Homo sapiens_hsa040620.99951562
51* Salmonella infection_Homo sapiens_hsa051320.97065573
52Endometrial cancer_Homo sapiens_hsa052130.96103560
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93438874
54Renal cell carcinoma_Homo sapiens_hsa052110.90938428
55* HTLV-I infection_Homo sapiens_hsa051660.90462140
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.88892666
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88457504
58* Pancreatic cancer_Homo sapiens_hsa052120.87193591
59DNA replication_Homo sapiens_hsa030300.86354130
60* Epstein-Barr virus infection_Homo sapiens_hsa051690.85774995
61Autoimmune thyroid disease_Homo sapiens_hsa053200.85383242
62Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84761942
63* Prolactin signaling pathway_Homo sapiens_hsa049170.84028283
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.83812768
65Lysosome_Homo sapiens_hsa041420.82845918
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.82761820
67Platelet activation_Homo sapiens_hsa046110.82394859
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81395703
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81188588
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79141109
71Rheumatoid arthritis_Homo sapiens_hsa053230.78818812
72* Amoebiasis_Homo sapiens_hsa051460.77218931
73Insulin signaling pathway_Homo sapiens_hsa049100.76447724
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76021230
75Glioma_Homo sapiens_hsa052140.75634700
76* Adipocytokine signaling pathway_Homo sapiens_hsa049200.74254123
77p53 signaling pathway_Homo sapiens_hsa041150.71904303
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70882152
79* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70737721
80* Viral carcinogenesis_Homo sapiens_hsa052030.70719231
81* Sphingolipid signaling pathway_Homo sapiens_hsa040710.68119451
82* Insulin resistance_Homo sapiens_hsa049310.68070711
83Notch signaling pathway_Homo sapiens_hsa043300.64829517
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63553302
85Base excision repair_Homo sapiens_hsa034100.62599498
86Galactose metabolism_Homo sapiens_hsa000520.62088214
87Type I diabetes mellitus_Homo sapiens_hsa049400.62087394
88Focal adhesion_Homo sapiens_hsa045100.59418535
89ErbB signaling pathway_Homo sapiens_hsa040120.59202630
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.59116481
91Proteoglycans in cancer_Homo sapiens_hsa052050.57216628
92Vibrio cholerae infection_Homo sapiens_hsa051100.56740581
93* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56161638
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55476771
95African trypanosomiasis_Homo sapiens_hsa051430.55344450
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.55217344
97Inositol phosphate metabolism_Homo sapiens_hsa005620.54833242
98* Neurotrophin signaling pathway_Homo sapiens_hsa047220.54812283
99Choline metabolism in cancer_Homo sapiens_hsa052310.53667172
100AMPK signaling pathway_Homo sapiens_hsa041520.53383389
101VEGF signaling pathway_Homo sapiens_hsa043700.52862139
102Selenocompound metabolism_Homo sapiens_hsa004500.52524620
103Biosynthesis of amino acids_Homo sapiens_hsa012300.51425310
104Phagosome_Homo sapiens_hsa041450.51326963
105ECM-receptor interaction_Homo sapiens_hsa045120.50106751
106Sulfur relay system_Homo sapiens_hsa041220.50055154
107Fructose and mannose metabolism_Homo sapiens_hsa000510.50008047
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49414663
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.48791267
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45956948
111One carbon pool by folate_Homo sapiens_hsa006700.45507133
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44907159
113MicroRNAs in cancer_Homo sapiens_hsa052060.44741498
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.41359642
115Pentose phosphate pathway_Homo sapiens_hsa000300.39056123
116* HIF-1 signaling pathway_Homo sapiens_hsa040660.39038563
117Folate biosynthesis_Homo sapiens_hsa007900.37874647
118Bladder cancer_Homo sapiens_hsa052190.36841173
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35295313
120Prion diseases_Homo sapiens_hsa050200.34967104
121FoxO signaling pathway_Homo sapiens_hsa040680.34434003
122Non-small cell lung cancer_Homo sapiens_hsa052230.33494378
123PPAR signaling pathway_Homo sapiens_hsa033200.32281381
124Adherens junction_Homo sapiens_hsa045200.31388171
125Colorectal cancer_Homo sapiens_hsa052100.30024801
126* Prostate cancer_Homo sapiens_hsa052150.30013722

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