RELB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* NIK/NF-kappaB signaling (GO:0038061)6.75899657
2antigen processing and presentation of endogenous antigen (GO:0019883)5.64958391
3regulation of interleukin-12 biosynthetic process (GO:0045075)5.31952246
4regulation of dendritic cell antigen processing and presentation (GO:0002604)5.29057533
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.01838025
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.01838025
7response to muramyl dipeptide (GO:0032495)4.74236764
8positive regulation of gamma-delta T cell activation (GO:0046645)4.66016466
9positive regulation of antigen processing and presentation (GO:0002579)4.55112176
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50542128
11regulation of RIG-I signaling pathway (GO:0039535)4.43231247
12neutrophil activation involved in immune response (GO:0002283)4.38126030
13negative thymic T cell selection (GO:0045060)4.21879801
14regulation of antigen processing and presentation (GO:0002577)4.05784782
15positive regulation of natural killer cell differentiation (GO:0032825)4.04487535
16negative T cell selection (GO:0043383)3.99436286
17natural killer cell mediated cytotoxicity (GO:0042267)3.95501945
18natural killer cell mediated immunity (GO:0002228)3.95501945
19neutrophil activation (GO:0042119)3.91869882
20positive regulation of interleukin-12 production (GO:0032735)3.90025557
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.85234621
22granulocyte activation (GO:0036230)3.83695065
23regulation of vitamin D biosynthetic process (GO:0060556)3.82197453
24positive regulation of humoral immune response (GO:0002922)3.71262997
25interferon-gamma-mediated signaling pathway (GO:0060333)3.70349265
26* myeloid dendritic cell differentiation (GO:0043011)3.62549755
27regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.61359101
28JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.60696835
29type I interferon signaling pathway (GO:0060337)3.58988647
30cellular response to type I interferon (GO:0071357)3.58988647
31response to type I interferon (GO:0034340)3.58645312
32regulation of gamma-delta T cell activation (GO:0046643)3.53106088
33positive regulation of interleukin-2 production (GO:0032743)3.50044386
34regulation of T-helper 1 cell differentiation (GO:0045625)3.46809649
35regulation of interleukin-12 production (GO:0032655)3.46471737
36regulation of necroptotic process (GO:0060544)3.45737413
37response to peptidoglycan (GO:0032494)3.44365936
38detection of other organism (GO:0098543)3.43885859
39growth hormone receptor signaling pathway (GO:0060396)3.41716456
40response to protozoan (GO:0001562)3.41179028
41detection of bacterium (GO:0016045)3.38915040
42negative regulation of cytokine production involved in immune response (GO:0002719)3.38202326
43regulation of interferon-beta biosynthetic process (GO:0045357)3.36825534
44regulation of gamma-delta T cell differentiation (GO:0045586)3.36176078
45immunoglobulin mediated immune response (GO:0016064)3.35438860
46* myeloid dendritic cell activation (GO:0001773)3.35011451
47T cell migration (GO:0072678)3.34055450
48positive regulation of interferon-alpha production (GO:0032727)3.32519954
49germinal center formation (GO:0002467)3.29850157
50interferon-gamma secretion (GO:0072643)3.28362552
51positive thymic T cell selection (GO:0045059)3.28206313
52mature B cell differentiation (GO:0002335)3.26862226
53positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.26805807
54thymic T cell selection (GO:0045061)3.26096961
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.21640175
56regulation of alpha-beta T cell proliferation (GO:0046640)3.21271705
57regulation of interferon-alpha production (GO:0032647)3.19831160
58regulation of type I interferon-mediated signaling pathway (GO:0060338)3.16788634
59* dendritic cell differentiation (GO:0097028)3.15683726
60positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14110008
61regulation of vitamin metabolic process (GO:0030656)3.13829075
62regulation of hypersensitivity (GO:0002883)3.13124265
63negative regulation of erythrocyte differentiation (GO:0045647)3.13001794
64regulation of T cell tolerance induction (GO:0002664)3.12281685
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.10487583
66regulation of response to interferon-gamma (GO:0060330)3.06526100
67positive regulation of heat generation (GO:0031652)3.05429207
68cytokine secretion (GO:0050663)3.04866759
69leukocyte aggregation (GO:0070486)3.04390421
70regulation of integrin activation (GO:0033623)3.03694776
71positive regulation of chemokine biosynthetic process (GO:0045080)3.02950490
72negative regulation of interleukin-12 production (GO:0032695)3.02783592
73CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.02127527
74T cell selection (GO:0045058)3.00305942
75positive regulation of type 2 immune response (GO:0002830)2.99705328
76positive regulation by symbiont of host defense response (GO:0052509)2.99329456
77modulation by symbiont of host defense response (GO:0052031)2.99329456
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99329456
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99329456
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.99329456
81modulation by symbiont of host immune response (GO:0052553)2.99329456
82regulation of cytokine secretion involved in immune response (GO:0002739)2.97818178
83positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.96740453
84regulation of T-helper 2 cell differentiation (GO:0045628)2.95486383
85regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.92065331
86negative regulation of cell killing (GO:0031342)2.91787043
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.91787043
88positive regulation of T cell cytokine production (GO:0002726)2.91750709
89detection of external biotic stimulus (GO:0098581)2.90887865
90regulation of fever generation (GO:0031620)2.90785602
91cellular response to growth hormone stimulus (GO:0071378)2.90102142
92B cell mediated immunity (GO:0019724)2.89005188
93regulation of podosome assembly (GO:0071801)2.88724105
94negative regulation of necroptotic process (GO:0060546)2.87929995
95T-helper 1 type immune response (GO:0042088)2.87301882
96positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.86442481
97lymphocyte migration (GO:0072676)2.85522214
98tolerance induction (GO:0002507)2.85109922
99leukocyte mediated cytotoxicity (GO:0001909)2.84460696
100positive regulation of B cell differentiation (GO:0045579)2.84225446
101regulation of chemokine biosynthetic process (GO:0045073)2.82938993
102negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.82347321
103regulation of tolerance induction (GO:0002643)2.81824636
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81750699
105cellular response to interferon-beta (GO:0035458)2.81527533
106regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81385789
107defense response to protozoan (GO:0042832)2.81312915
108regulation of chronic inflammatory response (GO:0002676)2.80416261
109positive regulation of protein oligomerization (GO:0032461)2.80006424
110positive regulation of protein homooligomerization (GO:0032464)2.79964453
111regulation of interleukin-2 biosynthetic process (GO:0045076)2.79314160
112regulation of cellular extravasation (GO:0002691)2.77959163
113regulation of immunoglobulin secretion (GO:0051023)2.77849106
114lymphocyte mediated immunity (GO:0002449)2.76998347
115positive regulation of NF-kappaB import into nucleus (GO:0042346)2.76105372
116regulation of B cell receptor signaling pathway (GO:0050855)2.75531610
117myeloid cell activation involved in immune response (GO:0002275)2.75335248
118response to interleukin-15 (GO:0070672)2.75306543
119cellular response to interferon-gamma (GO:0071346)2.74492925
120macrophage activation involved in immune response (GO:0002281)2.74157296
121tumor necrosis factor-mediated signaling pathway (GO:0033209)2.73490346
122detection of molecule of bacterial origin (GO:0032490)2.72972898
123negative regulation of T cell mediated immunity (GO:0002710)2.72860274
124modulation by symbiont of host cellular process (GO:0044068)2.72839572
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.72652076
126positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71715422
127regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.70235059
128regulation of type 2 immune response (GO:0002828)2.68454101
129negative regulation of innate immune response (GO:0045824)2.68336787
130negative regulation of production of molecular mediator of immune response (GO:0002701)2.65666423
131response to interferon-gamma (GO:0034341)2.63990500
132cellular extravasation (GO:0045123)2.63777722
133detection of biotic stimulus (GO:0009595)2.60584036
134response to host immune response (GO:0052572)2.59806926
135response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59806926
136lymphocyte chemotaxis (GO:0048247)2.58930675
137macrophage activation (GO:0042116)2.56557791
138cellular response to lipopolysaccharide (GO:0071222)2.54253313
139regulation of mononuclear cell migration (GO:0071675)2.52202267
140regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.51628961
141positive regulation of interferon-beta production (GO:0032728)2.51200547
142regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.50555263
143regulation of T-helper cell differentiation (GO:0045622)2.50463832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.22724470
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.29128081
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.00124818
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.25436376
5EGR1_19374776_ChIP-ChIP_THP-1_Human4.17796938
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.07035167
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.84593001
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.81736772
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.50465439
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34701888
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.34384620
12* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22800113
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.20977852
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.18977236
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.09357304
16STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88276156
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76790279
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.75866678
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74759380
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45772515
21RUNX_20019798_ChIP-Seq_JUKART_Human2.28892733
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.27751777
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20684725
24MAF_26560356_Chip-Seq_TH1_Human2.20437767
25MYB_26560356_Chip-Seq_TH2_Human2.19517090
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.04910554
27MYB_26560356_Chip-Seq_TH1_Human1.93889429
28VDR_21846776_ChIP-Seq_THP-1_Human1.92463716
29LXR_22292898_ChIP-Seq_THP-1_Human1.91846717
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90083299
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.88089824
32MYC_22102868_ChIP-Seq_BL_Human1.86716432
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86510817
34VDR_24763502_ChIP-Seq_THP-1_Human1.85147704
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.81979630
36SPI1_23547873_ChIP-Seq_NB4_Human1.80916964
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70767220
38VDR_24787735_ChIP-Seq_THP-1_Human1.68115283
39TCF7_22412390_ChIP-Seq_EML_Mouse1.65836253
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64858127
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.61566231
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60029345
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.50034474
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.49883685
45PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48524433
46PU_27001747_Chip-Seq_BMDM_Mouse1.43701996
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42832048
48UTX_26944678_Chip-Seq_JUKART_Human1.42399303
49GATA3_27048872_Chip-Seq_THYMUS_Human1.39354164
50SPI1_23127762_ChIP-Seq_K562_Human1.38523877
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37875963
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.37047117
53RACK7_27058665_Chip-Seq_MCF-7_Human1.32162975
54* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30899883
55MAF_26560356_Chip-Seq_TH2_Human1.29218022
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27922441
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27356754
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24540565
59SCL_19346495_ChIP-Seq_HPC-7_Human1.23855740
60KDM2B_26808549_Chip-Seq_DND41_Human1.23823215
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20754201
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19790481
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.15991727
64GATA1_22025678_ChIP-Seq_K562_Human1.15878444
65TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15819354
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.14620913
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13536189
68SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13146693
69BCOR_27268052_Chip-Seq_Bcells_Human1.11926008
70NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11807444
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11328821
72SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09913579
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09913579
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08616880
75CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08188050
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.08108263
77BCL6_27268052_Chip-Seq_Bcells_Human1.06865025
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06261560
79GATA3_26560356_Chip-Seq_TH2_Human1.05236895
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00095899
81GATA1_19941826_ChIP-Seq_K562_Human0.99630358
82* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99283500
83ELF1_20517297_ChIP-Seq_JURKAT_Human0.98473020
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98023391
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97466491
86FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97462861
87SA1_27219007_Chip-Seq_ERYTHROID_Human0.96571740
88FOXO3_23340844_ChIP-Seq_DLD1_Human0.95978651
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95977778
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92551721
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92276223
92* KDM2B_26808549_Chip-Seq_K562_Human0.91493619
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91444185
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90557139
95PPARA_22158963_ChIP-Seq_LIVER_Mouse0.90241654
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86979903
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86713908
98* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86663199
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85467493
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80599192
101TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.79972675
102NCOR1_26117541_ChIP-Seq_K562_Human0.79749022
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79461230
104PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78099471
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.77776721
106UBF1/2_26484160_Chip-Seq_HMECs_Human0.77351541
107* SMRT_27268052_Chip-Seq_Bcells_Human0.77041014
108JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75169796
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.74951293
110EGR1_19032775_ChIP-ChIP_M12_Human0.74055849
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.73857182
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73664258
113CLOCK_20551151_ChIP-Seq_293T_Human0.72357264
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.71907639
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71899098
116KDM2B_26808549_Chip-Seq_JURKAT_Human0.69257793
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.68968218
118LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68946318
119* TFEB_21752829_ChIP-Seq_HELA_Human0.67526872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.75730073
2MP0000685_abnormal_immune_system4.22709270
3MP0003436_decreased_susceptibility_to3.24311883
4* MP0005387_immune_system_phenotype3.22942591
5* MP0001790_abnormal_immune_system3.22942591
6MP0009785_altered_susceptibility_to3.18732816
7MP0001348_abnormal_lacrimal_gland3.03469395
8MP0005000_abnormal_immune_tolerance2.98234486
9* MP0001800_abnormal_humoral_immune2.96879912
10MP0002166_altered_tumor_susceptibility2.92011676
11MP0005671_abnormal_response_to2.85841458
12* MP0002148_abnormal_hypersensitivity_rea2.84794595
13* MP0002452_abnormal_antigen_presenting2.75260581
14* MP0002723_abnormal_immune_serum2.62525383
15MP0002006_tumorigenesis2.59602120
16MP0003303_peritoneal_inflammation2.57457057
17* MP0005025_abnormal_response_to2.49582003
18* MP0002419_abnormal_innate_immunity2.44514089
19* MP0001819_abnormal_immune_cell2.40939571
20* MP0002420_abnormal_adaptive_immunity2.38646301
21MP0006082_CNS_inflammation2.37463438
22MP0002009_preneoplasia2.27458129
23* MP0004510_myositis2.23789497
24MP0003763_abnormal_thymus_physiology2.20144089
25MP0005451_abnormal_body_composition2.10933081
26MP0001853_heart_inflammation2.10313806
27* MP0002405_respiratory_system_inflammati2.01387185
28* MP0005310_abnormal_salivary_gland1.98187013
29* MP0000716_abnormal_immune_system1.92596727
30* MP0002398_abnormal_bone_marrow1.91120855
31* MP0004947_skin_inflammation1.88754480
32MP0002163_abnormal_gland_morphology1.88225169
33* MP0010155_abnormal_intestine_physiology1.84460640
34MP0003724_increased_susceptibility_to1.83305283
35MP0003300_gastrointestinal_ulcer1.75316597
36MP0001346_abnormal_lacrimal_gland1.71616851
37MP0009333_abnormal_splenocyte_physiolog1.69824272
38MP0010352_gastrointestinal_tract_polyps1.67541092
39* MP0001845_abnormal_inflammatory_respons1.66542479
40MP0003448_altered_tumor_morphology1.65531730
41MP0005076_abnormal_cell_differentiation1.63508225
42MP0000569_abnormal_digit_pigmentation1.60436959
43MP0009278_abnormal_bone_marrow1.58424008
44MP0002139_abnormal_hepatobiliary_system1.58331799
45MP0001533_abnormal_skeleton_physiology1.55482933
46MP0002877_abnormal_melanocyte_morpholog1.53930820
47* MP0002429_abnormal_blood_cell1.52718262
48MP0008260_abnormal_autophagy1.48670458
49* MP0002722_abnormal_immune_system1.48616322
50* MP0000689_abnormal_spleen_morphology1.48163950
51* MP0001873_stomach_inflammation1.44637342
52MP0001545_abnormal_hematopoietic_system1.38187642
53MP0005397_hematopoietic_system_phenotyp1.38187642
54MP0008004_abnormal_stomach_pH1.35414098
55MP0005166_decreased_susceptibility_to1.33264307
56MP0003091_abnormal_cell_migration1.32435867
57MP0002998_abnormal_bone_remodeling1.30898875
58MP0000858_altered_metastatic_potential1.30583995
59MP0009764_decreased_sensitivity_to1.30572483
60MP0005464_abnormal_platelet_physiology1.30091736
61MP0002396_abnormal_hematopoietic_system1.29529793
62MP0002933_joint_inflammation1.27171719
63* MP0008469_abnormal_protein_level1.23897967
64MP0003806_abnormal_nucleotide_metabolis1.22839407
65* MP0000703_abnormal_thymus_morphology1.21360994
66MP0008057_abnormal_DNA_replication1.19389815
67MP0003866_abnormal_defecation1.17052253
68* MP0003453_abnormal_keratinocyte_physiol1.13542734
69* MP0002138_abnormal_hepatobiliary_system1.13490355
70* MP0002254_reproductive_system_inflammat1.09113480
71MP0005058_abnormal_lysosome_morphology1.08431731
72MP0009840_abnormal_foam_cell1.02058707
73MP0000465_gastrointestinal_hemorrhage0.97252664
74MP0004808_abnormal_hematopoietic_stem0.96646669
75MP0003566_abnormal_cell_adhesion0.96161901
76* MP0000604_amyloidosis0.91444418
77MP0003656_abnormal_erythrocyte_physiolo0.91289190
78MP0002332_abnormal_exercise_endurance0.89633237
79MP0003828_pulmonary_edema0.89158918
80* MP0002277_abnormal_respiratory_mucosa0.87550071
81MP0005164_abnormal_response_to0.87206144
82* MP0001663_abnormal_digestive_system0.86343728
83MP0010307_abnormal_tumor_latency0.84175787
84MP0006054_spinal_hemorrhage0.83738307
85MP0001851_eye_inflammation0.82951695
86MP0001881_abnormal_mammary_gland0.82500993
87MP0005167_abnormal_blood-brain_barrier0.80872976
88MP0005174_abnormal_tail_pigmentation0.79975673
89MP0003183_abnormal_peptide_metabolism0.79967245
90MP0000490_abnormal_crypts_of0.78605230
91MP0005390_skeleton_phenotype0.77684947
92MP0003172_abnormal_lysosome_physiology0.77650989
93MP0000767_abnormal_smooth_muscle0.77381781
94MP0005379_endocrine/exocrine_gland_phen0.75571739
95MP0000627_abnormal_mammary_gland0.75489000
96MP0003690_abnormal_glial_cell0.75065144
97MP0000371_diluted_coat_color0.74114302
98MP0003045_fibrosis0.74094455
99MP0000343_altered_response_to0.73199889
100MP0000249_abnormal_blood_vessel0.72718884
101MP0001849_ear_inflammation0.69370475
102MP0009763_increased_sensitivity_to0.69176695
103MP0005165_increased_susceptibility_to0.69095073
104MP0003705_abnormal_hypodermis_morpholog0.67600195
105MP0001879_abnormal_lymphatic_vessel0.67580716
106MP0008874_decreased_physiological_sensi0.66593140
107MP0003795_abnormal_bone_structure0.65687331
108MP0002019_abnormal_tumor_incidence0.64561009
109MP0004883_abnormal_blood_vessel0.64325188
110MP0005023_abnormal_wound_healing0.64086516
111MP0001542_abnormal_bone_strength0.62992577
112* MP0002136_abnormal_kidney_physiology0.62914100
113* MP0000609_abnormal_liver_physiology0.62573345
114MP0000733_abnormal_muscle_development0.62290675
115MP0003279_aneurysm0.57796155
116* MP0001216_abnormal_epidermal_layer0.57509504
117MP0005621_abnormal_cell_physiology0.57090149
118MP0003075_altered_response_to0.57011732
119MP0004381_abnormal_hair_follicle0.56551761
120MP0003191_abnormal_cellular_cholesterol0.56249335
121MP0004782_abnormal_surfactant_physiolog0.55697841
122MP0002132_abnormal_respiratory_system0.54992890
123MP0003329_amyloid_beta_deposits0.54184680
124MP0004858_abnormal_nervous_system0.54116138
125MP0009765_abnormal_xenobiotic_induced0.50219038
126MP0000470_abnormal_stomach_morphology0.50032276

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.94896102
2Recurrent fungal infections (HP:0002841)5.14398544
3Recurrent abscess formation (HP:0002722)5.02836395
4Elevated erythrocyte sedimentation rate (HP:0003565)4.94911530
5Recurrent bacterial skin infections (HP:0005406)4.84943504
6Abnormality of liposaccharide metabolism (HP:0010968)4.81588148
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.81588148
8Abnormality of glycolipid metabolism (HP:0010969)4.81588148
9Optic neuritis (HP:0100653)4.59887411
10Retrobulbar optic neuritis (HP:0100654)4.59887411
11Mediastinal lymphadenopathy (HP:0100721)4.45591867
12Orchitis (HP:0100796)4.44418756
13Chronic mucocutaneous candidiasis (HP:0002728)4.42779569
14Recurrent cutaneous fungal infections (HP:0011370)4.42779569
15Myositis (HP:0100614)4.42386336
16Recurrent viral infections (HP:0004429)4.26453627
17Increased IgM level (HP:0003496)4.03122308
18Autoimmune thrombocytopenia (HP:0001973)3.92258781
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.89015973
20Chronic otitis media (HP:0000389)3.88118316
21Recurrent skin infections (HP:0001581)3.87259139
22Stomatitis (HP:0010280)3.86095798
23Abnormality of macrophages (HP:0004311)3.78123657
24Vasculitis (HP:0002633)3.71866695
25Systemic lupus erythematosus (HP:0002725)3.70111495
26Pulmonary infiltrates (HP:0002113)3.56480358
27Increased cerebral lipofuscin (HP:0011813)3.46869446
28Nasal polyposis (HP:0100582)3.46206784
29Loss of speech (HP:0002371)3.45138967
30Gastrointestinal infarctions (HP:0005244)3.42199255
31Dysostosis multiplex (HP:0000943)3.40998629
32Colitis (HP:0002583)3.29286182
33Arterial thrombosis (HP:0004420)3.25126542
34Vacuolated lymphocytes (HP:0001922)3.24933211
35Gingivitis (HP:0000230)3.21165245
36Increased IgE level (HP:0003212)3.19660281
37Recurrent gram-negative bacterial infections (HP:0005420)3.17576480
38Keratoconjunctivitis (HP:0001096)3.15133716
39Pustule (HP:0200039)3.15113334
40Eosinophilia (HP:0001880)3.11731729
41Leukocytosis (HP:0001974)3.11143969
42Inflammation of the large intestine (HP:0002037)3.06131184
43Periodontitis (HP:0000704)3.05396890
44Myocardial infarction (HP:0001658)3.04583996
45Agammaglobulinemia (HP:0004432)3.02289957
46Thrombocytosis (HP:0001894)2.98249218
47Abnormality of T cell number (HP:0011839)2.98121919
48Abnormality of the nasal mucosa (HP:0000433)2.96820357
49Panhypogammaglobulinemia (HP:0003139)2.93690870
50Fatigue (HP:0012378)2.93416778
51Hypergammaglobulinemia (HP:0010702)2.92010795
52Hematochezia (HP:0002573)2.87471329
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.86656972
54Gastrointestinal inflammation (HP:0004386)2.84412265
55Recurrent bronchitis (HP:0002837)2.81895852
56Keratoconjunctivitis sicca (HP:0001097)2.77045514
57Meningitis (HP:0001287)2.74550817
58Cellulitis (HP:0100658)2.72182228
59Disinhibition (HP:0000734)2.71368304
60Interstitial pulmonary disease (HP:0006530)2.70402283
61Granulocytopenia (HP:0001913)2.69061191
62Abnormality of the fingertips (HP:0001211)2.65150437
63Peritonitis (HP:0002586)2.65024838
64Obstructive lung disease (HP:0006536)2.64598756
65Chronic obstructive pulmonary disease (HP:0006510)2.64598756
66Abnormality of eosinophils (HP:0001879)2.62546385
67Hemoptysis (HP:0002105)2.61478398
68Increased serum ferritin (HP:0003281)2.61282286
69Malnutrition (HP:0004395)2.60063184
70Emphysema (HP:0002097)2.56732122
71Abnormality of T cells (HP:0002843)2.52805181
72Chronic diarrhea (HP:0002028)2.51777829
73Abnormality of polysaccharide metabolism (HP:0011012)2.51054735
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51054735
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51054735
76Prostate neoplasm (HP:0100787)2.48289337
77Abnormality of T cell physiology (HP:0011840)2.46981851
78Premature loss of primary teeth (HP:0006323)2.46651353
79T lymphocytopenia (HP:0005403)2.43972568
80Tetraparesis (HP:0002273)2.41392779
81Osteolytic defects of the hand bones (HP:0009699)2.41243721
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.41243721
83Gastrointestinal stroma tumor (HP:0100723)2.40588070
84Encephalitis (HP:0002383)2.37861432
85Restrictive lung disease (HP:0002091)2.37534521
86Urinary glycosaminoglycan excretion (HP:0003541)2.36106388
87Mucopolysacchariduria (HP:0008155)2.36106388
88Gingival bleeding (HP:0000225)2.35195665
89Abnormality of cells of the lymphoid lineage (HP:0012140)2.34891614
90Purpura (HP:0000979)2.34814996
91Petechiae (HP:0000967)2.33853106
92Axonal loss (HP:0003447)2.31849795
93IgA deficiency (HP:0002720)2.30758629
94Amyloidosis (HP:0011034)2.28713073
95Vertebral compression fractures (HP:0002953)2.28521613
96Basal ganglia calcification (HP:0002135)2.25013836
97Autoimmune hemolytic anemia (HP:0001890)2.24111705
98Nuclear cataract (HP:0100018)2.22824601
99Glomerulonephritis (HP:0000099)2.21215628
100Urticaria (HP:0001025)2.20176095
101Thick nail (HP:0001805)2.20119059
102Cheilitis (HP:0100825)2.18930167
103Gangrene (HP:0100758)2.18842426
104Persistence of primary teeth (HP:0006335)2.18333794
105Osteomyelitis (HP:0002754)2.18098643
106Hydroxyprolinuria (HP:0003080)2.17762538
107Abnormality of proline metabolism (HP:0010907)2.17762538
108Lymphopenia (HP:0001888)2.17694458
109Segmental peripheral demyelination/remyelination (HP:0003481)2.15539842
110Anhidrosis (HP:0000970)2.14354543
111Skin ulcer (HP:0200042)2.14333889
112Hepatosplenomegaly (HP:0001433)2.13393751
113Thyroiditis (HP:0100646)2.13099268
114IgG deficiency (HP:0004315)2.12889838
115Joint swelling (HP:0001386)2.11741030
116Chest pain (HP:0100749)2.11710988
117Recurrent pneumonia (HP:0006532)2.09950213
118Recurrent lower respiratory tract infections (HP:0002783)2.09800153
119Neurofibrillary tangles (HP:0002185)2.09723517
120Esophageal varix (HP:0002040)2.08978154
121IgM deficiency (HP:0002850)2.07413962
122Polycythemia (HP:0001901)2.06442362
123Chronic sinusitis (HP:0011109)2.05485881
124Spontaneous hematomas (HP:0007420)2.05478588
125Porencephaly (HP:0002132)2.04743264
126Severe combined immunodeficiency (HP:0004430)2.02980636
127Neuronal loss in central nervous system (HP:0002529)2.02974246
128Combined immunodeficiency (HP:0005387)2.02915697
129Abnormality of iron homeostasis (HP:0011031)2.01414916
130Arthralgia (HP:0002829)1.99110695
131Mutism (HP:0002300)1.97313409
132Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96926134
133Abnormality of the pleura (HP:0002103)1.96538270
134Progressive neurologic deterioration (HP:0002344)1.93242476
135Anorexia (HP:0002039)1.91241600
136Hypertensive crisis (HP:0100735)1.89874084
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.89578730
138Glomerulopathy (HP:0100820)1.89031110
139Pulmonary embolism (HP:0002204)1.88110034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K146.00369895
2TYK23.80733748
3JAK33.67252811
4TBK13.38507330
5* IKBKB3.21490330
6PRPF4B3.17997583
7MAP3K133.08989426
8IKBKE3.06879913
9MAP4K12.98513205
10IRAK32.73793258
11JAK12.57218307
12TAOK22.54113991
13IRAK42.45130014
14* CHUK2.43198136
15TAOK12.09872740
16TXK2.06998934
17FGFR42.05855923
18EPHB11.93219595
19KIT1.81507240
20RIPK41.76575168
21EPHA31.75240619
22BLK1.64819199
23SMG11.61714113
24TRIB31.56385505
25ZAP701.52481695
26RPS6KA41.52410652
27SIK11.49500851
28MST41.46759739
29DDR21.39295710
30FGFR31.37872087
31PIM11.37165543
32GRK71.34176210
33CSF1R1.32424427
34STK101.27069822
35CDC42BPA1.26693397
36NLK1.26409342
37PIM21.25509286
38SYK1.23005947
39MAP3K101.21610727
40JAK21.21489148
41CSK1.20026413
42BTK1.15676017
43LCK1.14367780
44CDK121.11079879
45IRAK21.08664055
46PTK61.06769908
47FES1.06392028
48FLT31.04934391
49TEC1.01193046
50HCK0.99975366
51GRK60.98042265
52ITK0.94060272
53PKN10.91434531
54TGFBR20.90206710
55IRAK10.90016471
56TNK20.87867145
57NEK90.85518257
58MAP3K30.85159157
59PRKAA20.84336266
60TESK20.82485760
61NME20.81882915
62TAOK30.81585975
63BMX0.79909285
64EIF2AK20.77236396
65ERN10.75018287
66FGR0.71806346
67MAPKAPK20.71136242
68RPS6KA50.70728274
69LRRK20.69799286
70ICK0.69689001
71PRKD20.67456427
72LYN0.66386435
73MAP3K50.64854442
74STK40.64297588
75MAP2K30.63558056
76TTN0.61352919
77ABL20.61130626
78BMPR20.60380912
79MARK20.59669915
80MARK30.57324762
81PRKCQ0.56235065
82ARAF0.55677735
83MAPK70.54981943
84MAP2K20.53603077
85PDPK10.52082812
86ABL10.51510080
87RPS6KL10.51001898
88RPS6KC10.51001898
89RPS6KA10.50966128
90MAP3K110.50562985
91PDK10.48672069
92STK30.47907991
93PRKCD0.46048589
94TESK10.45847958
95EGFR0.44196045
96PAK40.43880987
97RIPK10.42663795
98TYRO30.41587753
99MAPK40.41240106
100MAPK110.41172581
101MOS0.39309640
102STK240.39185178
103MAP3K80.38704304
104CDK90.36035382
105TRPM70.35563427
106INSR0.34747205
107SIK20.34488862
108MELK0.34122508
109NUAK10.33101460
110CDK40.32556020
111MAP2K60.32395392
112MAPK120.31503900
113KSR20.31397910
114DYRK1B0.31358893
115ALK0.30977669
116MATK0.30791865
117GSK3A0.30782340
118SIK30.30275335
119CLK10.29863752
120PDGFRA0.29543670
121MAP3K70.29406856
122HIPK20.29374635
123MAP3K10.29278854
124RPS6KA60.29082383
125KDR0.27370958
126RPS6KA20.25853737
127MST1R0.23312236
128PDGFRB0.23016133
129CDK60.22899986
130AKT10.20332148
131MAPK30.20082474
132TGFBR10.19976988
133PRKG20.19268462
134RAF10.18943629

Predicted pathways (KEGG)

RankGene SetZ-score
1* NF-kappa B signaling pathway_Homo sapiens_hsa040643.47135402
2Leishmaniasis_Homo sapiens_hsa051403.02188098
3Allograft rejection_Homo sapiens_hsa053302.90779877
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.72752099
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.71463523
6Graft-versus-host disease_Homo sapiens_hsa053322.67536393
7Measles_Homo sapiens_hsa051622.49021491
8TNF signaling pathway_Homo sapiens_hsa046682.39135437
9* Osteoclast differentiation_Homo sapiens_hsa043802.37442419
10Primary immunodeficiency_Homo sapiens_hsa053402.33665265
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.26046880
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23338771
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22936991
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.17522157
15Antigen processing and presentation_Homo sapiens_hsa046122.08401846
16Toxoplasmosis_Homo sapiens_hsa051452.06712046
17B cell receptor signaling pathway_Homo sapiens_hsa046621.96871291
18Legionellosis_Homo sapiens_hsa051341.91046815
19Apoptosis_Homo sapiens_hsa042101.88922179
20Herpes simplex infection_Homo sapiens_hsa051681.81219098
21Influenza A_Homo sapiens_hsa051641.80908279
22Autoimmune thyroid disease_Homo sapiens_hsa053201.77866314
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.77061911
24T cell receptor signaling pathway_Homo sapiens_hsa046601.68899923
25Asthma_Homo sapiens_hsa053101.65617039
26Tuberculosis_Homo sapiens_hsa051521.56937921
27Pertussis_Homo sapiens_hsa051331.53822476
28Hematopoietic cell lineage_Homo sapiens_hsa046401.51932770
29Chemokine signaling pathway_Homo sapiens_hsa040621.51603267
30Malaria_Homo sapiens_hsa051441.50442691
31Type I diabetes mellitus_Homo sapiens_hsa049401.49575258
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48256265
33Shigellosis_Homo sapiens_hsa051311.40577779
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34458121
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33724505
36Small cell lung cancer_Homo sapiens_hsa052221.31240112
37Acute myeloid leukemia_Homo sapiens_hsa052211.28735528
38Rheumatoid arthritis_Homo sapiens_hsa053231.28653452
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27700254
40Viral myocarditis_Homo sapiens_hsa054161.27438505
41Hepatitis B_Homo sapiens_hsa051611.26305762
42African trypanosomiasis_Homo sapiens_hsa051431.24674984
43Hepatitis C_Homo sapiens_hsa051601.18059705
44Staphylococcus aureus infection_Homo sapiens_hsa051501.16783262
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16402910
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.14717726
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14154980
48Prolactin signaling pathway_Homo sapiens_hsa049171.12043438
49Salmonella infection_Homo sapiens_hsa051321.10506465
50Chronic myeloid leukemia_Homo sapiens_hsa052201.08339326
51* Epstein-Barr virus infection_Homo sapiens_hsa051691.07253224
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.97655902
53Prion diseases_Homo sapiens_hsa050200.96980194
54p53 signaling pathway_Homo sapiens_hsa041150.95547622
55Bladder cancer_Homo sapiens_hsa052190.95175409
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93515225
57Viral carcinogenesis_Homo sapiens_hsa052030.86242888
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85487348
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.85214873
60Pancreatic cancer_Homo sapiens_hsa052120.82304671
61* HTLV-I infection_Homo sapiens_hsa051660.76599745
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.70220534
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69067231
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66515042
65MicroRNAs in cancer_Homo sapiens_hsa052060.63291318
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60834799
67Amoebiasis_Homo sapiens_hsa051460.60259962
68Lysosome_Homo sapiens_hsa041420.53884524
69HIF-1 signaling pathway_Homo sapiens_hsa040660.50691808
70* MAPK signaling pathway_Homo sapiens_hsa040100.49861268
71Insulin resistance_Homo sapiens_hsa049310.49853218
72FoxO signaling pathway_Homo sapiens_hsa040680.48878229
73Phagosome_Homo sapiens_hsa041450.48730172
74Platelet activation_Homo sapiens_hsa046110.48161917
75Systemic lupus erythematosus_Homo sapiens_hsa053220.47625308
76VEGF signaling pathway_Homo sapiens_hsa043700.45842837
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44376315
78Notch signaling pathway_Homo sapiens_hsa043300.41511156
79Pathways in cancer_Homo sapiens_hsa052000.40931251
80Proteoglycans in cancer_Homo sapiens_hsa052050.39766044
81Prostate cancer_Homo sapiens_hsa052150.39524168
82Galactose metabolism_Homo sapiens_hsa000520.38152554
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37795741
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37077199
85Adherens junction_Homo sapiens_hsa045200.36684610
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36257307
87Fructose and mannose metabolism_Homo sapiens_hsa000510.35951977
88Complement and coagulation cascades_Homo sapiens_hsa046100.34550865
89Dorso-ventral axis formation_Homo sapiens_hsa043200.33561914
90Type II diabetes mellitus_Homo sapiens_hsa049300.33363822
91Sphingolipid metabolism_Homo sapiens_hsa006000.32487314
92Other glycan degradation_Homo sapiens_hsa005110.31910407
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31702937
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.30625669
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30575344
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.30083478
97GnRH signaling pathway_Homo sapiens_hsa049120.27363055
98Endocytosis_Homo sapiens_hsa041440.26832572
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26419341
100Focal adhesion_Homo sapiens_hsa045100.25595802
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.25032116
102Endometrial cancer_Homo sapiens_hsa052130.24542460
103Colorectal cancer_Homo sapiens_hsa052100.21347703
104Renal cell carcinoma_Homo sapiens_hsa052110.20353327
105Non-small cell lung cancer_Homo sapiens_hsa052230.20103642
106ErbB signaling pathway_Homo sapiens_hsa040120.19784864
107Collecting duct acid secretion_Homo sapiens_hsa049660.19261751
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19234946
109mTOR signaling pathway_Homo sapiens_hsa041500.17245835
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16889727
111Insulin signaling pathway_Homo sapiens_hsa049100.16387319
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15588704
113Inositol phosphate metabolism_Homo sapiens_hsa005620.15307358
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12871508
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12049852

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