RELL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)5.61384785
2central nervous system myelination (GO:0022010)5.61384785
3fatty acid elongation (GO:0030497)5.11013755
4ensheathment of neurons (GO:0007272)5.02085855
5axon ensheathment (GO:0008366)5.02085855
6myelination (GO:0042552)4.93737034
7Rap protein signal transduction (GO:0032486)4.78000375
8adhesion of symbiont to host cell (GO:0044650)4.74310984
9virion attachment to host cell (GO:0019062)4.74310984
10detection of molecule of bacterial origin (GO:0032490)4.58006255
11leukocyte migration involved in inflammatory response (GO:0002523)4.52767754
12positive regulation of actin filament depolymerization (GO:0030836)4.51358843
13positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.43326234
14adhesion of symbiont to host (GO:0044406)4.15886934
15mitotic nuclear envelope reassembly (GO:0007084)4.12885795
16nuclear envelope reassembly (GO:0031468)4.12885795
17modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.98570818
18positive regulation by organism of defense response of other organism involved in symbiotic interact3.98570818
19modulation by symbiont of host immune response (GO:0052553)3.98570818
20positive regulation by symbiont of host defense response (GO:0052509)3.98570818
21modulation by symbiont of host defense response (GO:0052031)3.98570818
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.98570818
23cellular extravasation (GO:0045123)3.97192103
24cellular response to hepatocyte growth factor stimulus (GO:0035729)3.93648384
25response to hepatocyte growth factor (GO:0035728)3.93648384
26response to peptidoglycan (GO:0032494)3.90970361
27cholesterol biosynthetic process (GO:0006695)3.83868961
28positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.83445089
29negative regulation of neurotransmitter secretion (GO:0046929)3.82835599
30myelination in peripheral nervous system (GO:0022011)3.81504261
31peripheral nervous system axon ensheathment (GO:0032292)3.81504261
32negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.72449375
33macrophage activation involved in immune response (GO:0002281)3.64670779
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63987100
35amyloid precursor protein metabolic process (GO:0042982)3.63582822
36neutrophil activation involved in immune response (GO:0002283)3.59893473
37negative regulation of interleukin-12 production (GO:0032695)3.48293722
38positive regulation of gamma-delta T cell activation (GO:0046645)3.46814501
39amyloid precursor protein catabolic process (GO:0042987)3.46020181
40neutrophil mediated immunity (GO:0002446)3.45187234
41embryonic process involved in female pregnancy (GO:0060136)3.44900090
42macrophage activation (GO:0042116)3.43991407
43regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.43018809
44phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.41533811
45ear development (GO:0043583)3.40520937
46glycerophospholipid catabolic process (GO:0046475)3.39520976
47regulation of interferon-beta biosynthetic process (GO:0045357)3.35107955
48retina vasculature morphogenesis in camera-type eye (GO:0061299)3.32471357
49detection of external biotic stimulus (GO:0098581)3.28648596
50protein localization to endosome (GO:0036010)3.27616589
51sterol biosynthetic process (GO:0016126)3.23803962
52long-chain fatty acid biosynthetic process (GO:0042759)3.22622571
53response to muramyl dipeptide (GO:0032495)3.22090484
54response to lipoprotein particle (GO:0055094)3.19630500
55detection of other organism (GO:0098543)3.18842228
56interleukin-6-mediated signaling pathway (GO:0070102)3.16902286
57wound healing, spreading of cells (GO:0044319)3.16130322
58negative regulation of cell killing (GO:0031342)3.10544208
59negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.10544208
60glomerular filtration (GO:0003094)3.10181036
61regulation of B cell receptor signaling pathway (GO:0050855)3.08424805
62dermatan sulfate biosynthetic process (GO:0030208)3.08271157
63membrane protein ectodomain proteolysis (GO:0006509)3.06978433
64oligodendrocyte differentiation (GO:0048709)3.06497145
65platelet-derived growth factor receptor signaling pathway (GO:0048008)3.03408605
66nucleotide transmembrane transport (GO:1901679)3.02724526
67myelin maintenance (GO:0043217)3.02591946
68response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00258792
69response to host (GO:0075136)3.00258792
70response to host defenses (GO:0052200)3.00258792
71renal filtration (GO:0097205)2.97175903
72microglial cell activation (GO:0001774)2.96731300
73import into cell (GO:0098657)2.94999859
74response to host immune response (GO:0052572)2.94567120
75response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.94567120
76detection of biotic stimulus (GO:0009595)2.94365720
77regulation of necroptotic process (GO:0060544)2.91842267
78germinal center formation (GO:0002467)2.91393807
79semaphorin-plexin signaling pathway (GO:0071526)2.90517017
80asymmetric protein localization (GO:0008105)2.89594224
81positive regulation of osteoblast proliferation (GO:0033690)2.88953898
82leukocyte aggregation (GO:0070486)2.85703643
83establishment of endothelial barrier (GO:0061028)2.85078157
84peptidyl-tyrosine autophosphorylation (GO:0038083)2.84361572
85hypotonic response (GO:0006971)2.83927171
86blood vessel maturation (GO:0001955)2.82050349
87hepatocyte apoptotic process (GO:0097284)2.79731923
88membrane raft organization (GO:0031579)2.78846502
89dermatan sulfate metabolic process (GO:0030205)2.78132072
90heterotypic cell-cell adhesion (GO:0034113)2.72270840
91cellular response to ethanol (GO:0071361)2.67398906
92positive regulation of receptor recycling (GO:0001921)2.67373316
93myeloid leukocyte mediated immunity (GO:0002444)2.65609604
94glomerular visceral epithelial cell development (GO:0072015)2.63718720
95positive regulation of interleukin-17 production (GO:0032740)2.59712909
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59302442
97regulation of gamma-delta T cell activation (GO:0046643)2.59241114
98iron ion import (GO:0097286)2.58156999
99definitive hemopoiesis (GO:0060216)2.57994818
100isoprenoid biosynthetic process (GO:0008299)2.57660594
101lipopolysaccharide-mediated signaling pathway (GO:0031663)2.57219105
102positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57188199
103photoreceptor cell differentiation (GO:0046530)2.56776789
104eye photoreceptor cell differentiation (GO:0001754)2.56776789
105regulation of macrophage cytokine production (GO:0010935)2.55472110
106endothelial cell morphogenesis (GO:0001886)2.55267491
107Leydig cell differentiation (GO:0033327)2.55193734
108negative regulation of myoblast differentiation (GO:0045662)2.54856251
109pinocytosis (GO:0006907)2.54443782
110sphingosine metabolic process (GO:0006670)2.54175128
111positive regulation of catenin import into nucleus (GO:0035413)2.54160410
112regulation of interleukin-12 biosynthetic process (GO:0045075)2.52616871
113histone H3-K36 demethylation (GO:0070544)2.51967239
114wound healing, spreading of epidermal cells (GO:0035313)2.51966878
115mRNA transcription (GO:0009299)2.51893849
116positive regulation of interferon-alpha production (GO:0032727)2.51192417
117mesodermal cell differentiation (GO:0048333)2.51146557
118regulation of gamma-delta T cell differentiation (GO:0045586)2.51099935
119response to redox state (GO:0051775)2.48862183
120muscle cell migration (GO:0014812)2.48490526
121response to laminar fluid shear stress (GO:0034616)2.47919485
122antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47442077
123regulation of T-helper 2 cell differentiation (GO:0045628)2.47169477
124myeloid cell activation involved in immune response (GO:0002275)2.46147222
125endothelial cell proliferation (GO:0001935)2.45020705
126nuclear pore complex assembly (GO:0051292)2.43626727
127negative regulation of axon extension involved in axon guidance (GO:0048843)2.42756300
128sphingoid metabolic process (GO:0046519)2.40302817
129regulation of activation of Janus kinase activity (GO:0010533)2.40132346
130pyrimidine-containing compound transmembrane transport (GO:0072531)2.39985131
131insulin-like growth factor receptor signaling pathway (GO:0048009)2.39262485
132astrocyte development (GO:0014002)2.38946614
133apical protein localization (GO:0045176)2.38860420
134negative regulation of fatty acid transport (GO:2000192)2.38212247
135regulation of interferon-alpha production (GO:0032647)2.37365111
136cytoplasmic mRNA processing body assembly (GO:0033962)2.35331986
137negative regulation of interleukin-17 production (GO:0032700)2.35243143
138I-kappaB phosphorylation (GO:0007252)2.35218981
139mature B cell differentiation involved in immune response (GO:0002313)2.34967517
140neutrophil activation (GO:0042119)2.34885531
141T-helper 1 type immune response (GO:0042088)2.34774882
142myeloid cell homeostasis (GO:0002262)2.34029770
143regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.33675732
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.33488470
145production of molecular mediator involved in inflammatory response (GO:0002532)2.32054037
146diol metabolic process (GO:0034311)2.31859568
147hemidesmosome assembly (GO:0031581)2.31685432
148detection of bacterium (GO:0016045)2.31129415
149regulation of cell proliferation involved in kidney development (GO:1901722)2.30847009
150regulation of leukocyte degranulation (GO:0043300)2.29890896
151glomerular epithelial cell development (GO:0072310)2.29639262
152phospholipid translocation (GO:0045332)2.29511585
153lipid translocation (GO:0034204)2.29511585
154antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.28861068
155B cell receptor signaling pathway (GO:0050853)2.28691782
156estrogen metabolic process (GO:0008210)2.28643253
157angiogenesis involved in wound healing (GO:0060055)2.28396600
158growth hormone receptor signaling pathway (GO:0060396)2.28326841
159negative regulation of anoikis (GO:2000811)2.28020832
160membrane protein proteolysis (GO:0033619)2.27819933
161axon development (GO:0061564)2.27208023
162positive regulation of vasculogenesis (GO:2001214)2.27099195
163positive regulation of protein autophosphorylation (GO:0031954)2.26629731
164negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.26333141
165membrane assembly (GO:0071709)2.26257551
166antigen processing and presentation of endogenous antigen (GO:0019883)2.25946895
167negative regulation of T-helper cell differentiation (GO:0045623)2.25651760
168negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.25651760
169regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.25203994
170cell adhesion mediated by integrin (GO:0033627)2.24069583
171positive regulation of gliogenesis (GO:0014015)2.23350609
172regulation of collateral sprouting (GO:0048670)2.23221966
173regulation of interleukin-8 biosynthetic process (GO:0045414)2.22778640
174positive regulation of toll-like receptor signaling pathway (GO:0034123)2.22272763
175positive thymic T cell selection (GO:0045059)2.22126391
176dendritic cell migration (GO:0036336)2.21497600
177myeloid leukocyte activation (GO:0002274)2.20480991
178negative regulation of interleukin-8 production (GO:0032717)2.20422336
179positive regulation of oligodendrocyte differentiation (GO:0048714)2.19814868
180establishment of epithelial cell polarity (GO:0090162)2.19462092
181regulation of integrin-mediated signaling pathway (GO:2001044)2.19364772
182negative regulation of erythrocyte differentiation (GO:0045647)2.19337815
183regulation of protein polyubiquitination (GO:1902914)2.18655482
184early endosome to late endosome transport (GO:0045022)2.18617976
185granulocyte activation (GO:0036230)2.18296557
186substantia nigra development (GO:0021762)2.16858526
187positive regulation of chromosome segregation (GO:0051984)2.15495283
188creatine metabolic process (GO:0006600)2.15455871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.17990635
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.76852267
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.14688913
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.30043710
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.23693501
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.16166514
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.10138715
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.02582189
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.96825355
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.92917631
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86471191
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74175250
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.52170542
14KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.52170542
15KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.52170542
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36500357
17GATA1_22025678_ChIP-Seq_K562_Human2.23265152
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.23121769
19SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.07803592
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.01272717
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98276011
22* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98183695
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97620384
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96202275
25SOX2_20726797_ChIP-Seq_SW620_Human1.94156805
26PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.92754340
27SALL4_18804426_ChIP-ChIP_XEN_Mouse1.92373370
28CJUN_26792858_Chip-Seq_BT549_Human1.90748089
29CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.90561144
30SCL_19346495_ChIP-Seq_HPC-7_Human1.85542120
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.84232613
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.84023795
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.84023795
34* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82503152
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80659588
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.79320010
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.78930060
38* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69265689
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.68750422
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.67618675
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65217917
42SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64345453
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64345453
44SPI1_23127762_ChIP-Seq_K562_Human1.63911220
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.62581829
46VDR_24763502_ChIP-Seq_THP-1_Human1.59164163
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58724037
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51204286
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.50210384
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47453407
51AR_21572438_ChIP-Seq_LNCaP_Human1.46121460
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45246450
53TCF7_22412390_ChIP-Seq_EML_Mouse1.42905167
54* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40994825
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.40922058
56MYB_26560356_Chip-Seq_TH2_Human1.40278392
57* VDR_24787735_ChIP-Seq_THP-1_Human1.40012566
58NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39757258
59EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.38971497
60TP53_16413492_ChIP-PET_HCT116_Human1.37327215
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.37118198
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35177897
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.34750260
64GATA1_19941827_ChIP-Seq_MEL_Mouse1.33725425
65NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32935444
66E2F7_22180533_ChIP-Seq_HELA_Human1.31528615
67* MYB_26560356_Chip-Seq_TH1_Human1.31172684
68* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30768301
69PU_27001747_Chip-Seq_BMDM_Mouse1.30494400
70IRF8_27001747_Chip-Seq_BMDM_Mouse1.28998922
71GATA2_19941826_ChIP-Seq_K562_Human1.28419279
72* SPI1_23547873_ChIP-Seq_NB4_Human1.27599708
73CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26967669
74TP63_23658742_ChIP-Seq_EP156T_Human1.25511694
75TBX20_22328084_ChIP-Seq_HEART_Mouse1.24323246
76TBX20_22080862_ChIP-Seq_HEART_Mouse1.24323246
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.23819659
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23642481
79EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23319895
80AHR_22903824_ChIP-Seq_MCF-7_Human1.22761168
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22613364
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20133538
83UBF1/2_26484160_Chip-Seq_HMECs_Human1.19544119
84TP53_18474530_ChIP-ChIP_U2OS_Human1.19483073
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.18679503
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18652227
87GATA1_19941826_ChIP-Seq_K562_Human1.18502227
88ER_23166858_ChIP-Seq_MCF-7_Human1.18304085
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.17052412
90RUNX_20019798_ChIP-Seq_JUKART_Human1.16460663
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15510504
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15269366
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15076916
94* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14885651
95JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14339908
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13925969
97RXR_22108803_ChIP-Seq_LS180_Human1.13312899
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13304871
99* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13125006
100BRD4_25478319_ChIP-Seq_HGPS_Human1.12374738
101VDR_22108803_ChIP-Seq_LS180_Human1.11612917
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.10856488
103CLOCK_20551151_ChIP-Seq_293T_Human1.10803732
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10718773
105P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09924996
106MAF_26560356_Chip-Seq_TH1_Human1.09805382
107VDR_21846776_ChIP-Seq_THP-1_Human1.08567749
108IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07978149
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06096375
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05829485
111* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05718064
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04866049
113NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04183881
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.03191358
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03060337
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02398171
117NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02203662
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.99237852
119FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98973303
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98177892
121GATA3_27048872_Chip-Seq_THYMUS_Human0.95591836
122KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.95419179
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.93639990
124ELK3_25401928_ChIP-Seq_HUVEC_Human0.93227408
125EGR1_19374776_ChIP-ChIP_THP-1_Human0.93109730
126* LXR_22158963_ChIP-Seq_LIVER_Mouse0.92750672
127TAF15_26573619_Chip-Seq_HEK293_Human0.92656375
128* GATA4_25053715_ChIP-Seq_YYC3_Human0.90740024
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89909617
130FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88374313
131CDX2_20551321_ChIP-Seq_CACO-2_Human0.88084904
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.87983846
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86275720
134IRF1_19129219_ChIP-ChIP_H3396_Human0.85712541
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85149279
136SOX17_20123909_ChIP-Seq_XEN_Mouse0.85002877
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84361149
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83150439
139CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82409619
140RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81916697
141TCF3_18692474_ChIP-Seq_MESCs_Mouse0.81431810
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.80921288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination3.20475021
2MP0008438_abnormal_cutaneous_collagen3.19867696
3MP0000383_abnormal_hair_follicle2.88769364
4MP0003690_abnormal_glial_cell2.77048789
5MP0003136_yellow_coat_color2.71202074
6MP0000569_abnormal_digit_pigmentation2.69919626
7MP0003950_abnormal_plasma_membrane2.56912514
8MP0003191_abnormal_cellular_cholesterol2.55492499
9MP0004272_abnormal_basement_membrane2.51945202
10MP0003300_gastrointestinal_ulcer2.50173418
11MP0010678_abnormal_skin_adnexa2.41013450
12MP0003453_abnormal_keratinocyte_physiol2.37759271
13MP0005171_absent_coat_pigmentation2.30983881
14MP0002796_impaired_skin_barrier2.30587889
15MP0005623_abnormal_meninges_morphology2.11035528
16MP0008057_abnormal_DNA_replication2.10153087
17MP0002332_abnormal_exercise_endurance2.08509124
18MP0004381_abnormal_hair_follicle2.06539560
19MP0008260_abnormal_autophagy2.05542856
20MP0005408_hypopigmentation2.03963126
21MP0001346_abnormal_lacrimal_gland2.01784668
22MP0003724_increased_susceptibility_to2.00674076
23MP0002009_preneoplasia1.92028129
24MP0002060_abnormal_skin_morphology1.83731432
25MP0001835_abnormal_antigen_presentation1.81317481
26MP0002877_abnormal_melanocyte_morpholog1.80645257
27MP0000647_abnormal_sebaceous_gland1.80270780
28MP0002295_abnormal_pulmonary_circulatio1.76143820
29MP0002166_altered_tumor_susceptibility1.74206670
30MP0000467_abnormal_esophagus_morphology1.69003994
31MP0003656_abnormal_erythrocyte_physiolo1.67540878
32MP0000462_abnormal_digestive_system1.62143816
33MP0005076_abnormal_cell_differentiation1.60839316
34MP0003763_abnormal_thymus_physiology1.59630199
35MP0006054_spinal_hemorrhage1.58131885
36MP0001851_eye_inflammation1.57978634
37MP0003045_fibrosis1.54690060
38MP0002098_abnormal_vibrissa_morphology1.54168422
39MP0005464_abnormal_platelet_physiology1.51794050
40MP0005275_abnormal_skin_tensile1.50707120
41MP0009384_cardiac_valve_regurgitation1.49374886
42MP0004484_altered_response_of1.48592196
43MP0010234_abnormal_vibrissa_follicle1.47588856
44MP0004808_abnormal_hematopoietic_stem1.47200388
45MP0000733_abnormal_muscle_development1.45432231
46MP0005451_abnormal_body_composition1.44961043
47MP0004883_abnormal_blood_vessel1.44667662
48MP0000762_abnormal_tongue_morphology1.40897213
49MP0003828_pulmonary_edema1.40868113
50MP0005409_darkened_coat_color1.38510936
51MP0003566_abnormal_cell_adhesion1.37812011
52MP0004510_myositis1.37265400
53MP0001879_abnormal_lymphatic_vessel1.36727746
54MP0003448_altered_tumor_morphology1.36635586
55MP0001243_abnormal_dermal_layer1.34767128
56MP0010368_abnormal_lymphatic_system1.34586432
57MP0005025_abnormal_response_to1.33825679
58MP0002254_reproductive_system_inflammat1.33466747
59MP0004233_abnormal_muscle_weight1.33369940
60MP0001216_abnormal_epidermal_layer1.33257107
61MP0000465_gastrointestinal_hemorrhage1.32762787
62MP0003937_abnormal_limbs/digits/tail_de1.32089543
63MP0002148_abnormal_hypersensitivity_rea1.32066562
64MP0000516_abnormal_urinary_system1.31468396
65MP0005367_renal/urinary_system_phenotyp1.31468396
66MP0003221_abnormal_cardiomyocyte_apopto1.29654189
67MP0002452_abnormal_antigen_presenting1.26370025
68MP0001800_abnormal_humoral_immune1.24205855
69MP0005501_abnormal_skin_physiology1.22893256
70MP0000749_muscle_degeneration1.22801142
71MP0002006_tumorigenesis1.21644680
72MP0002396_abnormal_hematopoietic_system1.20411357
73MP0003091_abnormal_cell_migration1.20255230
74MP0002723_abnormal_immune_serum1.19589566
75MP0001545_abnormal_hematopoietic_system1.19586263
76MP0005397_hematopoietic_system_phenotyp1.19586263
77MP0003705_abnormal_hypodermis_morpholog1.19491863
78MP0009764_decreased_sensitivity_to1.19396445
79MP0001485_abnormal_pinna_reflex1.18641758
80MP0002420_abnormal_adaptive_immunity1.18045681
81MP0002419_abnormal_innate_immunity1.17206941
82MP0001819_abnormal_immune_cell1.16227706
83MP0000377_abnormal_hair_follicle1.16212766
84MP0000767_abnormal_smooth_muscle1.15197488
85MP0000249_abnormal_blood_vessel1.14829872
86MP0000685_abnormal_immune_system1.14610418
87MP0005310_abnormal_salivary_gland1.13501169
88MP0005023_abnormal_wound_healing1.13401661
89MP0000858_altered_metastatic_potential1.12770581
90MP0001727_abnormal_embryo_implantation1.11628239
91MP0009840_abnormal_foam_cell1.10564215
92MP0005388_respiratory_system_phenotype1.08303043
93MP0002133_abnormal_respiratory_system1.08303043
94MP0003303_peritoneal_inflammation1.08219547
95MP0005000_abnormal_immune_tolerance1.07939293
96MP0000015_abnormal_ear_pigmentation1.07714140
97MP0008004_abnormal_stomach_pH1.06969405
98MP0004742_abnormal_vestibular_system1.06733780
99MP0001533_abnormal_skeleton_physiology1.06046076
100MP0009278_abnormal_bone_marrow1.05578195
101MP0004885_abnormal_endolymph1.05242923
102MP0004947_skin_inflammation1.05169418
103MP0005058_abnormal_lysosome_morphology1.04295348
104MP0001915_intracranial_hemorrhage1.03503093
105MP0004134_abnormal_chest_morphology1.03211018
106MP0004130_abnormal_muscle_cell1.02981569
107MP0003172_abnormal_lysosome_physiology1.02913375
108MP0009250_abnormal_appendicular_skeleto1.02659110
109MP0001958_emphysema1.02303613
110MP0003646_muscle_fatigue1.01305121
111MP0005164_abnormal_response_to1.00311010
112MP0001542_abnormal_bone_strength1.00195176
113MP0010155_abnormal_intestine_physiology1.00112872
114MP0003634_abnormal_glial_cell0.97026898
115MP0003075_altered_response_to0.96526508
116MP0003279_aneurysm0.96510254
117MP0003436_decreased_susceptibility_to0.95538438
118MP0005165_increased_susceptibility_to0.95106746
119MP0004185_abnormal_adipocyte_glucose0.95052501
120MP0002398_abnormal_bone_marrow0.94365165
121MP0000427_abnormal_hair_cycle0.94060861
122MP0003632_abnormal_nervous_system0.93588931
123MP0003385_abnormal_body_wall0.93586154
124MP0010771_integument_phenotype0.91082478
125MP0001845_abnormal_inflammatory_respons0.90571402
126MP0000716_abnormal_immune_system0.90452806
127MP0006082_CNS_inflammation0.90327619
128MP0004084_abnormal_cardiac_muscle0.89962994
129MP0002998_abnormal_bone_remodeling0.89525566
130MP0002168_other_aberrant_phenotype0.89101199
131MP0002277_abnormal_respiratory_mucosa0.89035002
132MP0002722_abnormal_immune_system0.87611276
133MP0001853_heart_inflammation0.87593922
134MP0009785_altered_susceptibility_to0.87173514
135MP0003183_abnormal_peptide_metabolism0.86764750
136MP0002405_respiratory_system_inflammati0.85742085
137MP0010352_gastrointestinal_tract_polyps0.84655923
138MP0000343_altered_response_to0.82098872
139MP0000627_abnormal_mammary_gland0.81105630
140MP0000372_irregular_coat_pigmentation0.79915507
141MP0000613_abnormal_salivary_gland0.79858801
142MP0005387_immune_system_phenotype0.79623979
143MP0001790_abnormal_immune_system0.79623979
144MP0005167_abnormal_blood-brain_barrier0.79439930
145MP0005390_skeleton_phenotype0.79077013
146MP0001614_abnormal_blood_vessel0.78549812
147MP0005503_abnormal_tendon_morphology0.78325236
148MP0002933_joint_inflammation0.77813981
149MP0005508_abnormal_skeleton_morphology0.77488468
150MP0000470_abnormal_stomach_morphology0.75531487
151MP0000432_abnormal_head_morphology0.75263481
152MP0001299_abnormal_eye_distance/0.74406770
153MP0001191_abnormal_skin_condition0.74104625
154MP0005257_abnormal_intraocular_pressure0.74090182

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)5.89891403
2Parakeratosis (HP:0001036)5.35755608
3Thick nail (HP:0001805)4.15095370
4Spontaneous hematomas (HP:0007420)3.63203708
5Premature rupture of membranes (HP:0001788)3.52307730
6Subacute progressive viral hepatitis (HP:0006572)3.44722665
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.44426612
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.28165975
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.28165975
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.25997186
11Orchitis (HP:0100796)3.10765399
12Akinesia (HP:0002304)3.06315377
13Difficulty running (HP:0009046)3.05002163
14Congenital ichthyosiform erythroderma (HP:0007431)3.02767510
15Chromsome breakage (HP:0040012)3.00943213
16Hemorrhage of the eye (HP:0011885)2.95514300
17Adrenal hypoplasia (HP:0000835)2.95495488
18Small epiphyses (HP:0010585)2.88880293
19Arterial tortuosity (HP:0005116)2.88427257
20Myositis (HP:0100614)2.86354614
21Optic neuritis (HP:0100653)2.85498153
22Retrobulbar optic neuritis (HP:0100654)2.85498153
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.84166825
24Osteolytic defects of the hand bones (HP:0009699)2.84166825
25Gingivitis (HP:0000230)2.77045620
26Stenosis of the external auditory canal (HP:0000402)2.74217697
27Premature skin wrinkling (HP:0100678)2.72595861
28Increased connective tissue (HP:0009025)2.72346044
29Aortic aneurysm (HP:0004942)2.67995720
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67288647
31Absent hand (HP:0004050)2.59941534
32Myocardial infarction (HP:0001658)2.59583601
33Nemaline bodies (HP:0003798)2.58543498
34Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.56532521
35Vascular tortuosity (HP:0004948)2.52574561
36Coronal craniosynostosis (HP:0004440)2.50887118
37Esophageal atresia (HP:0002032)2.50754793
38Cerebral aneurysm (HP:0004944)2.47571126
39Muscle fiber inclusion bodies (HP:0100299)2.46207027
40Cupped ear (HP:0000378)2.46195544
41Erythroderma (HP:0001019)2.43358270
42Neurofibrillary tangles (HP:0002185)2.42610811
43Esophageal varix (HP:0002040)2.42026003
44T lymphocytopenia (HP:0005403)2.41819022
45Gastrointestinal infarctions (HP:0005244)2.40739197
46Gingival bleeding (HP:0000225)2.38215803
47Epiphyseal dysplasia (HP:0002656)2.37152892
48Muscle fiber splitting (HP:0003555)2.36380779
49Keratoconjunctivitis sicca (HP:0001097)2.35618366
50Arterial thrombosis (HP:0004420)2.34450231
51Absent frontal sinuses (HP:0002688)2.34307004
52Distal lower limb muscle weakness (HP:0009053)2.30852369
53Chin dimple (HP:0010751)2.30706165
54Papillary thyroid carcinoma (HP:0002895)2.29240723
55Relative macrocephaly (HP:0004482)2.28752367
56Conical tooth (HP:0000698)2.27650685
57Breast hypoplasia (HP:0003187)2.26440508
58Interstitial pulmonary disease (HP:0006530)2.25099659
59Fused cervical vertebrae (HP:0002949)2.24335095
60Cellulitis (HP:0100658)2.21162495
61Abnormality of T cell number (HP:0011839)2.21019149
62Recurrent gram-negative bacterial infections (HP:0005420)2.20382910
63Aortic dissection (HP:0002647)2.20259092
64Epistaxis (HP:0000421)2.17728684
65Keratoconjunctivitis (HP:0001096)2.17402045
66Viral hepatitis (HP:0006562)2.16632761
67Abnormality of the vasculature of the conjunctiva (HP:0008054)2.14200324
68Dilatation of the ascending aorta (HP:0005111)2.13088854
69Anomalous pulmonary venous return (HP:0010772)2.12871383
70Hepatosplenomegaly (HP:0001433)2.12363419
71Autoamputation (HP:0001218)2.12353623
72Distal lower limb amyotrophy (HP:0008944)2.12301710
73White forelock (HP:0002211)2.12225817
74Conjunctival telangiectasia (HP:0000524)2.11619042
75Fatigue (HP:0012378)2.09308779
76Polycythemia (HP:0001901)2.08501088
77Prolonged bleeding time (HP:0003010)2.08220636
78Abnormality of the fetal cardiovascular system (HP:0010948)2.06897715
79Abnormal umbilical cord blood vessels (HP:0011403)2.06897715
80Single umbilical artery (HP:0001195)2.06897715
81Milia (HP:0001056)2.06112892
82Abnormality of the pulmonary veins (HP:0011718)2.05350176
83Recurrent fungal infections (HP:0002841)2.04202804
84Delayed epiphyseal ossification (HP:0002663)2.03745727
85Abnormality of the phalanges of the 2nd finger (HP:0009541)2.03095642
86Chest pain (HP:0100749)2.02631939
87Abnormality of macrophages (HP:0004311)2.02191112
88Spondylolisthesis (HP:0003302)2.02101789
89Bilateral sensorineural hearing impairment (HP:0008619)2.02031086
90Patchy hypopigmentation of hair (HP:0011365)2.00387566
91Recurrent abscess formation (HP:0002722)1.99585060
92Focal segmental glomerulosclerosis (HP:0000097)1.98078672
93Peripheral hypomyelination (HP:0007182)1.97911177
94Congenital sensorineural hearing impairment (HP:0008527)1.97380247
95Autoimmune hemolytic anemia (HP:0001890)1.95909208
96Colitis (HP:0002583)1.94914162
97Syringomyelia (HP:0003396)1.94195445
98Spinal cord lesions (HP:0100561)1.94195445
99Frequent falls (HP:0002359)1.92349240
100Recurrent skin infections (HP:0001581)1.91558833
101Hypoplasia of the iris (HP:0007676)1.91139424
102Asymmetric septal hypertrophy (HP:0001670)1.90743517
103Abnormal hemoglobin (HP:0011902)1.90136864
104Abnormality of the distal phalanges of the toes (HP:0010182)1.89574744
105Abnormality of the corticospinal tract (HP:0002492)1.89380121
106Barrel-shaped chest (HP:0001552)1.89341342
107Abnormality of the fingertips (HP:0001211)1.89227928
108Elevated erythrocyte sedimentation rate (HP:0003565)1.88529602
109Broad face (HP:0000283)1.88351829
110Abnormality of skeletal muscle fiber size (HP:0012084)1.87734079
111Asymmetry of the thorax (HP:0001555)1.86582633
112Menorrhagia (HP:0000132)1.86296973
113Protrusio acetabuli (HP:0003179)1.85027707
114Abnormality of incisor morphology (HP:0011063)1.84542659
115EMG: myopathic abnormalities (HP:0003458)1.83628299
116Round ear (HP:0100830)1.83402586
117Hypotrichosis (HP:0001006)1.82872201
118Difficulty climbing stairs (HP:0003551)1.82334563
119Aneurysm (HP:0002617)1.82317567
120Overgrowth (HP:0001548)1.81897022
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.81474056
122Mitral valve prolapse (HP:0001634)1.81280021
123Flat acetabular roof (HP:0003180)1.81029577
124Duplicated collecting system (HP:0000081)1.80551297
125Periodontitis (HP:0000704)1.79781834
126Atrophic scars (HP:0001075)1.79653247
127Abnormal platelet volume (HP:0011876)1.79612010
128Increased variability in muscle fiber diameter (HP:0003557)1.79014199
129Anhidrosis (HP:0000970)1.78159416
130Mitral stenosis (HP:0001718)1.77737258
131Hematochezia (HP:0002573)1.77612509
132Wormian bones (HP:0002645)1.76998402
133Ridged nail (HP:0001807)1.76229103
134Stridor (HP:0010307)1.75972645
135Mediastinal lymphadenopathy (HP:0100721)1.75472815
136Centrally nucleated skeletal muscle fibers (HP:0003687)1.75294081
137Dislocated radial head (HP:0003083)1.74784995
138Onion bulb formation (HP:0003383)1.74440822
139Ileus (HP:0002595)1.73399894
140Abnormality of the umbilical cord (HP:0010881)1.73198688
141Abnormality of the parathyroid morphology (HP:0011766)1.73147391
142Scapular winging (HP:0003691)1.73105708
143Abnormality of the 2nd finger (HP:0004100)1.73099711
144Acute myeloid leukemia (HP:0004808)1.73049066
145Micronodular cirrhosis (HP:0001413)1.72659980
146Hemoptysis (HP:0002105)1.72649554
147Spastic paraparesis (HP:0002313)1.72263203
148Portal hypertension (HP:0001409)1.71966326
149Abnormal auditory evoked potentials (HP:0006958)1.71494418
150Ulnar bowing (HP:0003031)1.71094958
151Diminished movement (HP:0002374)1.70805123
152Chronic mucocutaneous candidiasis (HP:0002728)1.70656663
153Recurrent cutaneous fungal infections (HP:0011370)1.70656663
154Glucose intolerance (HP:0000833)1.70331068
155Alopecia of scalp (HP:0002293)1.69951175
156Distal arthrogryposis (HP:0005684)1.67971958
157Irregular epiphyses (HP:0010582)1.67930126
158Prostate neoplasm (HP:0100787)1.67920393
159Increased mean platelet volume (HP:0011877)1.66134390
160Recurrent bacterial skin infections (HP:0005406)1.65412197
161Hypoalphalipoproteinemia (HP:0003233)1.65000232
162Large earlobe (HP:0009748)1.64716264
163Increased IgE level (HP:0003212)1.64362552
164Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.64097681
165Abnormality of the nasal septum (HP:0000419)1.64096158
166Abnormal vertebral ossification (HP:0100569)1.63893558
167Purpura (HP:0000979)1.63822273
168Asplenia (HP:0001746)1.62185581
169Slow saccadic eye movements (HP:0000514)1.62097259
170Vertebral clefting (HP:0008428)1.61918699
171Amyloidosis (HP:0011034)1.61917967
172Short hallux (HP:0010109)1.61735209
173Depressed nasal tip (HP:0000437)1.61367368
174Eosinophilia (HP:0001880)1.60716947
175Peritonitis (HP:0002586)1.60262504
176Abnormality of dentin (HP:0010299)1.59456913
177Hyporeflexia of lower limbs (HP:0002600)1.58489932
178Cone-rod dystrophy (HP:0000548)1.58155469
179Ectopic kidney (HP:0000086)1.57511598
180Abnormality of eosinophils (HP:0001879)1.57253723
181Aplasia/Hypoplasia of the spleen (HP:0010451)1.55060344
182Hypoplastic pelvis (HP:0008839)1.54249494
183Prolonged neonatal jaundice (HP:0006579)1.53077324
184Eczematoid dermatitis (HP:0000976)1.53002587
185Abnormality of the renal collecting system (HP:0004742)1.52647097
186Pterygium (HP:0001059)1.52286667
187Absent radius (HP:0003974)1.51805300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.46124505
2EPHB13.62650801
3OXSR13.35102536
4MST43.14075078
5PBK2.73776155
6MAP2K32.64613926
7TTN2.62069842
8MET2.58009590
9TNIK2.44572592
10BCR2.30719417
11TRPM72.24866204
12MAP3K142.11862315
13CLK12.06140546
14LATS11.94476896
15CDK121.89828898
16EPHA21.88965775
17NEK91.79642068
18STK101.79009431
19FES1.77635734
20PRPF4B1.77307628
21OBSCN1.72796906
22ZAP701.67381406
23TIE11.66713225
24JAK11.65043442
25NEK61.62563539
26GRK61.60300795
27TYK21.59790100
28IRAK41.57792913
29FGR1.52928005
30WNK41.52846680
31MAP3K31.50175228
32CSK1.45405582
33TEC1.32278348
34FGFR21.31816384
35MAP3K61.31397179
36SGK31.30801282
37MAPK151.30416459
38ICK1.30002902
39FGFR31.29663919
40HCK1.28756246
41BTK1.25735486
42EPHB21.25634362
43STK41.23892502
44JAK31.23309244
45TRIB31.22480612
46ERBB41.20789502
47ERN11.20373852
48EEF2K1.19711314
49PKN11.17557230
50SGK21.17538901
51BRD41.14681751
52MAP3K11.14636295
53KSR21.14125197
54FER1.13556631
55TAOK31.10839679
56STK31.10770155
57SCYL21.09428150
58RIPK41.08689233
59NUAK11.08126229
60TYRO31.07465690
61DDR21.06518305
62JAK21.05290969
63BMX1.04871037
64ACVR1B1.03942689
65IRAK31.02883155
66IKBKB0.99540419
67WNK10.95712737
68AKT30.94070866
69ROCK20.93848163
70IRAK10.93390425
71BMPR1B0.91480919
72RET0.89856345
73TGFBR20.87906728
74KDR0.87080308
75PTK2B0.86467027
76MAP3K130.85882250
77FGFR40.82016797
78PKN20.81881610
79LRRK20.79617832
80MARK20.79515930
81MELK0.79178646
82PIM20.78578659
83CSNK1A1L0.78373944
84ABL20.78140099
85RPS6KB20.77857105
86LIMK10.77029631
87PDGFRB0.75781341
88CDK190.74469514
89PDPK10.74461601
90MAPKAPK50.73842416
91PDK10.72221023
92FRK0.71170894
93YES10.70473360
94ABL10.70446650
95PRKAA20.70223486
96SYK0.69571433
97NLK0.69305612
98STK380.67531429
99MST1R0.67479330
100BRSK20.66499120
101MKNK20.65732439
102RAF10.63524088
103MOS0.63306256
104PTK20.63107379
105MTOR0.61747965
106CSNK1G30.60344592
107MAP3K20.60314643
108GSK3A0.58684700
109CSNK1G10.58434049
110MAP4K10.57951283
111AURKA0.56583673
112UHMK10.56444296
113PDGFRA0.55837992
114MAPK110.54702047
115MKNK10.54183659
116MAP3K70.54114294
117CDK70.53348446
118MARK30.53183626
119PRKCQ0.52426076
120PAK30.52414673
121LYN0.52300313
122IRAK20.51356387
123CDK60.50696936
124CSF1R0.49347092
125MAP3K100.47377604
126MAPK120.46810595
127EGFR0.46338630
128PAK20.45654781
129MAPK70.45491075
130EPHA30.45399384
131SGK2230.44624606
132SGK4940.44624606
133RIPK10.44473822
134BLK0.43074493
135TBK10.42583958
136MAP2K20.42412691
137RPS6KA20.42310361
138BMPR20.41615837
139MAPKAPK20.41193645
140NTRK10.40572955
141IKBKE0.40302254
142TTK0.39159270
143MAP3K80.38645533
144INSR0.37969577
145PTK60.37964829
146PIM10.37210075
147DMPK0.36661322
148ROCK10.32972024
149ERBB30.32701245
150MUSK0.30749572
151LCK0.30170299
152PAK60.30117467
153GRK10.30029181
154ITK0.29633446
155PIK3CG0.29148800
156CHUK0.28880758
157CSNK1D0.27254957

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001004.25247612
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.89591629
3Ether lipid metabolism_Homo sapiens_hsa005652.41840645
4Sphingolipid metabolism_Homo sapiens_hsa006002.20147636
5Fatty acid elongation_Homo sapiens_hsa000622.08686034
6ECM-receptor interaction_Homo sapiens_hsa045121.96702161
7Malaria_Homo sapiens_hsa051441.89694345
8Sulfur metabolism_Homo sapiens_hsa009201.85275948
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.80712813
10Acute myeloid leukemia_Homo sapiens_hsa052211.77318845
11Non-small cell lung cancer_Homo sapiens_hsa052231.76983778
12Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.71887895
13Leukocyte transendothelial migration_Homo sapiens_hsa046701.68015601
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.62642404
15Renal cell carcinoma_Homo sapiens_hsa052111.52480069
16Shigellosis_Homo sapiens_hsa051311.51478313
17Axon guidance_Homo sapiens_hsa043601.49864442
18Tight junction_Homo sapiens_hsa045301.48278575
19TGF-beta signaling pathway_Homo sapiens_hsa043501.41515711
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40113778
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38706478
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38059668
23Endometrial cancer_Homo sapiens_hsa052131.34469834
24Systemic lupus erythematosus_Homo sapiens_hsa053221.33692805
25Dorso-ventral axis formation_Homo sapiens_hsa043201.32974981
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.32091871
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31306875
28Rheumatoid arthritis_Homo sapiens_hsa053231.29757460
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.28358564
30Linoleic acid metabolism_Homo sapiens_hsa005911.26910344
31FoxO signaling pathway_Homo sapiens_hsa040681.26114529
32Salmonella infection_Homo sapiens_hsa051321.26106533
33Prolactin signaling pathway_Homo sapiens_hsa049171.25203264
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24808055
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24711899
36Focal adhesion_Homo sapiens_hsa045101.24556679
37MicroRNAs in cancer_Homo sapiens_hsa052061.22892118
38T cell receptor signaling pathway_Homo sapiens_hsa046601.22049367
39Inositol phosphate metabolism_Homo sapiens_hsa005621.21388886
40Proteoglycans in cancer_Homo sapiens_hsa052051.21016862
41Arachidonic acid metabolism_Homo sapiens_hsa005901.21013702
42Influenza A_Homo sapiens_hsa051641.20874831
43Lysosome_Homo sapiens_hsa041421.19754955
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19641997
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.18213011
46Small cell lung cancer_Homo sapiens_hsa052221.18173542
47HIF-1 signaling pathway_Homo sapiens_hsa040661.16268961
48Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.15565529
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14606673
50Protein export_Homo sapiens_hsa030601.13810632
51Viral carcinogenesis_Homo sapiens_hsa052031.12544649
52VEGF signaling pathway_Homo sapiens_hsa043701.11320136
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10619574
54Hippo signaling pathway_Homo sapiens_hsa043901.10042961
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09766747
56Adherens junction_Homo sapiens_hsa045201.08442169
57Neurotrophin signaling pathway_Homo sapiens_hsa047221.07170388
58Pertussis_Homo sapiens_hsa051331.06016456
59Insulin resistance_Homo sapiens_hsa049311.05653666
60Phagosome_Homo sapiens_hsa041451.04927420
61mTOR signaling pathway_Homo sapiens_hsa041501.03661854
62Glioma_Homo sapiens_hsa052141.03487844
63Prostate cancer_Homo sapiens_hsa052151.03030079
64Ovarian steroidogenesis_Homo sapiens_hsa049131.01362102
65Non-homologous end-joining_Homo sapiens_hsa034501.00582488
66Leishmaniasis_Homo sapiens_hsa051400.99884496
67Histidine metabolism_Homo sapiens_hsa003400.96051215
68Basal cell carcinoma_Homo sapiens_hsa052170.96024329
69Hepatitis C_Homo sapiens_hsa051600.95822547
70Glutathione metabolism_Homo sapiens_hsa004800.95007275
71Amoebiasis_Homo sapiens_hsa051460.94533306
72Autoimmune thyroid disease_Homo sapiens_hsa053200.94517316
73Toxoplasmosis_Homo sapiens_hsa051450.93089220
74Thyroid cancer_Homo sapiens_hsa052160.92670824
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92486735
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.92337583
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91037145
78Colorectal cancer_Homo sapiens_hsa052100.90697153
79Osteoclast differentiation_Homo sapiens_hsa043800.90340884
80African trypanosomiasis_Homo sapiens_hsa051430.90235441
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89567676
82Staphylococcus aureus infection_Homo sapiens_hsa051500.88729262
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.88501617
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86707647
85Pancreatic cancer_Homo sapiens_hsa052120.86681918
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86359408
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.85997040
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84566972
89TNF signaling pathway_Homo sapiens_hsa046680.81280459
90Alcoholism_Homo sapiens_hsa050340.80480596
91Choline metabolism in cancer_Homo sapiens_hsa052310.79769497
92Ras signaling pathway_Homo sapiens_hsa040140.76078059
93Platelet activation_Homo sapiens_hsa046110.75458291
94Endocytosis_Homo sapiens_hsa041440.74769300
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73837543
96GnRH signaling pathway_Homo sapiens_hsa049120.71768192
97Graft-versus-host disease_Homo sapiens_hsa053320.70513451
98Insulin signaling pathway_Homo sapiens_hsa049100.70460187
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70330216
100Apoptosis_Homo sapiens_hsa042100.70103635
101Pathways in cancer_Homo sapiens_hsa052000.68840540
102Herpes simplex infection_Homo sapiens_hsa051680.66820985
103B cell receptor signaling pathway_Homo sapiens_hsa046620.65996090
104Hedgehog signaling pathway_Homo sapiens_hsa043400.65153355
105Chronic myeloid leukemia_Homo sapiens_hsa052200.65084933
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.63041838
107Type II diabetes mellitus_Homo sapiens_hsa049300.62548482
108Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61528235
109Notch signaling pathway_Homo sapiens_hsa043300.61322355
110Chemokine signaling pathway_Homo sapiens_hsa040620.61243627
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59510871
112Viral myocarditis_Homo sapiens_hsa054160.59365194
113Hematopoietic cell lineage_Homo sapiens_hsa046400.59302637
114Rap1 signaling pathway_Homo sapiens_hsa040150.59164415
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57866303
116Protein digestion and absorption_Homo sapiens_hsa049740.57850066
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57693311
118Bladder cancer_Homo sapiens_hsa052190.55988413
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55863506
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55785635
121Other glycan degradation_Homo sapiens_hsa005110.55453676
122Estrogen signaling pathway_Homo sapiens_hsa049150.55021574
123Legionellosis_Homo sapiens_hsa051340.54944687
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.54604980
125Arginine and proline metabolism_Homo sapiens_hsa003300.53914741
126Fanconi anemia pathway_Homo sapiens_hsa034600.53598716
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52957384
128Measles_Homo sapiens_hsa051620.52436579
129Tuberculosis_Homo sapiens_hsa051520.52092086
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.51888999
131Complement and coagulation cascades_Homo sapiens_hsa046100.49560392
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.48862341
133p53 signaling pathway_Homo sapiens_hsa041150.48235453
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47607593
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47529151
136Basal transcription factors_Homo sapiens_hsa030220.46501214
137Cell cycle_Homo sapiens_hsa041100.45487895
138Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45324913
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44658903
140Hepatitis B_Homo sapiens_hsa051610.41978027
141ErbB signaling pathway_Homo sapiens_hsa040120.41060174
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40407254

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »