RELN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)6.98748912
2negative regulation of fibrinolysis (GO:0051918)6.94191180
3plasma lipoprotein particle assembly (GO:0034377)6.46206096
4low-density lipoprotein particle remodeling (GO:0034374)6.07099024
5regulation of fibrinolysis (GO:0051917)5.94690486
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78067972
7protein-lipid complex assembly (GO:0065005)5.76929469
8regulation of protein activation cascade (GO:2000257)5.63527000
9protein carboxylation (GO:0018214)5.62642620
10peptidyl-glutamic acid carboxylation (GO:0017187)5.62642620
11vocalization behavior (GO:0071625)5.51687945
12regulation of complement activation (GO:0030449)5.51218402
13cellular potassium ion homeostasis (GO:0030007)5.43141403
14regulation of apoptotic cell clearance (GO:2000425)5.34333435
15intestinal cholesterol absorption (GO:0030299)5.31483944
16synaptic vesicle exocytosis (GO:0016079)5.26966572
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.26870963
18synaptic vesicle maturation (GO:0016188)5.18425411
19locomotory exploration behavior (GO:0035641)5.01032268
20cholesterol efflux (GO:0033344)4.96420279
21G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.85778746
22protein-lipid complex remodeling (GO:0034368)4.82049387
23macromolecular complex remodeling (GO:0034367)4.82049387
24plasma lipoprotein particle remodeling (GO:0034369)4.82049387
25response to pheromone (GO:0019236)4.78970793
26* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78289196
27gamma-aminobutyric acid transport (GO:0015812)4.74316315
28pyrimidine nucleobase catabolic process (GO:0006208)4.70310107
29regulation of cholesterol esterification (GO:0010872)4.68533787
30plasma lipoprotein particle organization (GO:0071827)4.67488563
31blood coagulation, intrinsic pathway (GO:0007597)4.65390392
32glutamate secretion (GO:0014047)4.54400766
33neuron cell-cell adhesion (GO:0007158)4.53202740
34regulation of synaptic vesicle exocytosis (GO:2000300)4.50539834
35protein-lipid complex subunit organization (GO:0071825)4.40532677
36glutamate receptor signaling pathway (GO:0007215)4.40520287
37neurotransmitter secretion (GO:0007269)4.37075621
38embryonic retina morphogenesis in camera-type eye (GO:0060059)4.34436141
39* positive regulation of synapse maturation (GO:0090129)4.24055834
40cerebellar granule cell differentiation (GO:0021707)4.23223920
41* regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20990918
42ionotropic glutamate receptor signaling pathway (GO:0035235)4.19812812
43* protein localization to synapse (GO:0035418)4.18895614
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.13021702
45* layer formation in cerebral cortex (GO:0021819)4.12035655
46regulation of bile acid biosynthetic process (GO:0070857)4.08976228
47high-density lipoprotein particle remodeling (GO:0034375)4.07602813
48regulation of cholesterol homeostasis (GO:2000188)4.00952739
49regulation of plasminogen activation (GO:0010755)4.00040706
50regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.98747947
51reverse cholesterol transport (GO:0043691)3.97111957
52plasma lipoprotein particle clearance (GO:0034381)3.96269096
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.95028603
54L-phenylalanine catabolic process (GO:0006559)3.95028603
55sodium ion export (GO:0071436)3.92566086
56gamma-aminobutyric acid signaling pathway (GO:0007214)3.92363913
57exploration behavior (GO:0035640)3.89913850
58synaptic transmission, glutamatergic (GO:0035249)3.89632717
59negative regulation of protein activation cascade (GO:2000258)3.89382562
60lung epithelium development (GO:0060428)3.85360734
61regulation of synapse structural plasticity (GO:0051823)3.85299785
62neuron-neuron synaptic transmission (GO:0007270)3.84129439
63nucleobase catabolic process (GO:0046113)3.83145603
64regulation of synaptic vesicle transport (GO:1902803)3.81212856
65* regulation of glutamate receptor signaling pathway (GO:1900449)3.79340339
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.78685130
67nephron epithelium morphogenesis (GO:0072088)3.76048890
68nephron tubule morphogenesis (GO:0072078)3.76048890
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75134782
70synaptic vesicle endocytosis (GO:0048488)3.75128892
71cerebellar Purkinje cell differentiation (GO:0021702)3.73863108
72dendrite morphogenesis (GO:0048813)3.72877034
73potassium ion homeostasis (GO:0055075)3.71323300
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.69224566
75complement activation, alternative pathway (GO:0006957)3.67342871
76negative regulation of sodium ion transport (GO:0010766)3.65202917
77positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.64991763
78mating behavior (GO:0007617)3.63686368
79L-phenylalanine metabolic process (GO:0006558)3.63674397
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.63674397
81prepulse inhibition (GO:0060134)3.60225047
82regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.60212122
83regulation of long-term neuronal synaptic plasticity (GO:0048169)3.56404639
84intestinal absorption (GO:0050892)3.52833520
85synapse assembly (GO:0007416)3.52820422
86* neurotransmitter-gated ion channel clustering (GO:0072578)3.52680479
87neurotransmitter transport (GO:0006836)3.50916197
88regulation of cholesterol biosynthetic process (GO:0045540)3.48618878
89neuron recognition (GO:0008038)3.46090919
90dendritic spine morphogenesis (GO:0060997)3.44104743
91regulation of non-canonical Wnt signaling pathway (GO:2000050)3.41482669
92* regulation of synaptic transmission, glutamatergic (GO:0051966)3.41363562
93regulation of neuronal synaptic plasticity (GO:0048168)3.40068078
94diacylglycerol metabolic process (GO:0046339)3.35572805
95negative regulation of cholesterol transport (GO:0032375)3.34288045
96negative regulation of sterol transport (GO:0032372)3.34288045
97low-density lipoprotein particle clearance (GO:0034383)3.33655870
98proline transport (GO:0015824)3.32964847
99detection of light stimulus involved in visual perception (GO:0050908)3.31905106
100detection of light stimulus involved in sensory perception (GO:0050962)3.31905106
101urinary tract smooth muscle contraction (GO:0014848)3.31347938
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.31314271
103cell migration in hindbrain (GO:0021535)3.30318262
104postsynaptic membrane organization (GO:0001941)3.29359046
105response to auditory stimulus (GO:0010996)3.27852731
106neuronal action potential propagation (GO:0019227)3.24502400
107transmission of nerve impulse (GO:0019226)3.23133899
108axon ensheathment in central nervous system (GO:0032291)3.22722517
109central nervous system myelination (GO:0022010)3.22722517
110cell communication by electrical coupling (GO:0010644)3.19819533
111* long-term memory (GO:0007616)3.19416351
112membrane hyperpolarization (GO:0060081)3.18262643
113regulation of neurotransmitter levels (GO:0001505)3.15534580
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14726897
115central nervous system projection neuron axonogenesis (GO:0021952)3.14508634
116C4-dicarboxylate transport (GO:0015740)3.13314186
117positive regulation of extracellular matrix organization (GO:1903055)3.13003404
118cell differentiation in hindbrain (GO:0021533)3.12894108
119* regulation of synapse maturation (GO:0090128)3.12760794
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10048097
121regulation of neurotransmitter secretion (GO:0046928)3.06903023
122axon cargo transport (GO:0008088)3.06233656
123striatum development (GO:0021756)3.05937043
124negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05826630
125negative regulation of cytosolic calcium ion concentration (GO:0051481)3.04079560
126retinal rod cell development (GO:0046548)3.02296919
127* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01963382
128positive regulation of blood coagulation (GO:0030194)3.01836568
129positive regulation of hemostasis (GO:1900048)3.01836568
130glutamate metabolic process (GO:0006536)3.01584483
131response to prostaglandin (GO:0034694)3.00269359
132lipoprotein metabolic process (GO:0042157)2.99890845
133behavioral response to cocaine (GO:0048148)2.99613797
134* positive regulation of membrane potential (GO:0045838)2.99350082
135axonal fasciculation (GO:0007413)2.98714108
136activation of protein kinase A activity (GO:0034199)2.98626936
137sterol transport (GO:0015918)2.98067143
138cholesterol transport (GO:0030301)2.98067143
139auditory behavior (GO:0031223)2.97366382
140neuromuscular process controlling balance (GO:0050885)2.96500168
141synapse organization (GO:0050808)2.96049460
142negative regulation of complement activation (GO:0045916)2.95896263
143positive regulation of potassium ion transmembrane transport (GO:1901381)2.95132220
144cellular sodium ion homeostasis (GO:0006883)2.94877467
145cellular response to prostaglandin stimulus (GO:0071379)2.94548952
146* regulation of postsynaptic membrane potential (GO:0060078)2.93356638
147positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91893615
148* positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89970052
149long-term synaptic potentiation (GO:0060291)2.89085581
150membrane depolarization during action potential (GO:0086010)2.88839522
151long term synaptic depression (GO:0060292)2.88426276
152regulation of neurotransmitter transport (GO:0051588)2.86188319
153mitochondrion transport along microtubule (GO:0047497)2.85868451
154establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.85868451
155regulation of norepinephrine secretion (GO:0014061)2.85458216
156innervation (GO:0060384)2.85322414
157drinking behavior (GO:0042756)2.84610577
158regulation of humoral immune response (GO:0002920)2.84499814
159positive regulation of steroid metabolic process (GO:0045940)2.84372401
160* regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.84035235
161renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.83759925
162negative regulation of hemostasis (GO:1900047)2.82212923
163negative regulation of blood coagulation (GO:0030195)2.82212923
164phospholipid efflux (GO:0033700)2.82166381
165peptidyl-glutamic acid modification (GO:0018200)2.81888877
166regulation of vesicle fusion (GO:0031338)2.81632158
167behavioral defense response (GO:0002209)2.81032315
168behavioral fear response (GO:0001662)2.81032315
169adult walking behavior (GO:0007628)2.80686812
170renal tubule morphogenesis (GO:0061333)2.79227329
171cholesterol homeostasis (GO:0042632)2.77744774
172artery smooth muscle contraction (GO:0014824)2.76606192
173regulation of ARF protein signal transduction (GO:0032012)2.76325243
174protein activation cascade (GO:0072376)2.75650576
175proline metabolic process (GO:0006560)2.75218149
176sterol homeostasis (GO:0055092)2.75133952
177phosphate ion homeostasis (GO:0055062)2.75048327
178trivalent inorganic anion homeostasis (GO:0072506)2.75048327
179negative regulation of astrocyte differentiation (GO:0048712)2.74933392
180negative regulation of norepinephrine secretion (GO:0010700)2.73058658
181dicarboxylic acid biosynthetic process (GO:0043650)2.72773011
182lipoprotein transport (GO:0042953)2.71155883
183fibrinolysis (GO:0042730)2.71033819
184positive regulation of coagulation (GO:0050820)2.70041284
185cellular anion homeostasis (GO:0030002)2.69255908
186positive regulation of hormone biosynthetic process (GO:0046886)2.65801432
187acute-phase response (GO:0006953)2.65723293
188negative regulation of lipase activity (GO:0060192)2.62912614
189regulation of extracellular matrix organization (GO:1903053)2.56392077
190negative regulation of coagulation (GO:0050819)2.56112671
191positive regulation of lipoprotein lipase activity (GO:0051006)2.55055152
192positive regulation of triglyceride lipase activity (GO:0061365)2.55055152
193positive regulation of hormone metabolic process (GO:0032352)2.54877317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.63785502
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.90734846
3EZH2_22144423_ChIP-Seq_EOC_Human4.60631838
4GBX2_23144817_ChIP-Seq_PC3_Human3.67116701
5* FOXA2_19822575_ChIP-Seq_HepG2_Human3.48575407
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.94356008
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.86956417
8* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83071316
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79132287
10* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78098315
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.61023371
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56855898
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43998931
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.43538104
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.43538104
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.41885484
17* DROSHA_22980978_ChIP-Seq_HELA_Human2.41237883
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38123170
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35769004
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.33782173
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.30725835
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.29603246
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.29553323
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.28859449
25* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.25945720
26* EZH2_27304074_Chip-Seq_ESCs_Mouse2.23250022
27* HNF4A_19822575_ChIP-Seq_HepG2_Human2.17347029
28* EED_16625203_ChIP-ChIP_MESCs_Mouse2.13499890
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12860573
30* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08806950
31TCF4_18268006_ChIP-ChIP_LS174T_Human2.08642476
32* REST_18959480_ChIP-ChIP_MESCs_Mouse2.08408269
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.07315686
34RARB_27405468_Chip-Seq_BRAIN_Mouse2.04041272
35ESR1_15608294_ChIP-ChIP_MCF-7_Human2.03719663
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94977382
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88545000
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.85780508
39* AR_21572438_ChIP-Seq_LNCaP_Human1.85522454
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84778716
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83550086
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77828242
43TAF15_26573619_Chip-Seq_HEK293_Human1.76956083
44ZNF263_19887448_ChIP-Seq_K562_Human1.76616838
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71431930
46* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70403534
47CTNNB1_20460455_ChIP-Seq_HCT116_Human1.62998548
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.58747341
49FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54991035
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49894675
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49325163
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47857606
53CLOCK_20551151_ChIP-Seq_293T_Human1.43927487
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43736662
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43555147
56* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43391067
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.41143965
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38135245
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34276535
60SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33575714
61AR_19668381_ChIP-Seq_PC3_Human1.33151077
62* STAT3_23295773_ChIP-Seq_U87_Human1.32071429
63P300_19829295_ChIP-Seq_ESCs_Human1.31744784
64RING1B_27294783_Chip-Seq_ESCs_Mouse1.29327288
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29188281
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.29019774
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.28613139
68ZNF274_21170338_ChIP-Seq_K562_Hela1.27730245
69IGF1R_20145208_ChIP-Seq_DFB_Human1.27324860
70TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.27308494
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.25667701
72* PIAS1_25552417_ChIP-Seq_VCAP_Human1.23943645
73* CBX2_27304074_Chip-Seq_ESCs_Mouse1.23875759
74* AR_25329375_ChIP-Seq_VCAP_Human1.22909449
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22835941
76* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22059315
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.20259317
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20113406
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.19562037
80P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19327768
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.18995786
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.18089283
83* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16387331
84* TCF4_23295773_ChIP-Seq_U87_Human1.16084966
85RING1B_27294783_Chip-Seq_NPCs_Mouse1.15989038
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14702610
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14475219
88* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14402949
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13877335
90* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12773327
91* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11888788
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11084960
93* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10607344
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10101952
95* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09846831
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09727359
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09547964
98ISL1_27105846_Chip-Seq_CPCs_Mouse1.08100628
99* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07619892
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07419848
101SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07146708
102DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07062052
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05875754
104SMAD4_21741376_ChIP-Seq_HESCs_Human1.04951951
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03938023
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03938023
107* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03293713
108* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03070803
109CDX2_20551321_ChIP-Seq_CACO-2_Human1.02962845
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.01701233
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00678852
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00672865
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.00576946
114RNF2_27304074_Chip-Seq_NSC_Mouse0.99604475
115* KDM2B_26808549_Chip-Seq_K562_Human0.98328651
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97249547
117AHR_22903824_ChIP-Seq_MCF-7_Human0.95972204
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.95723747
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95585247
120BCAT_22108803_ChIP-Seq_LS180_Human0.95267877
121CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94699189
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94689682
123SMAD3_21741376_ChIP-Seq_ESCs_Human0.92776818
124* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92422846
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92187945
126HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92121473
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91645882
128* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.91220415
129RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91109284
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91074719
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91036111
132FUS_26573619_Chip-Seq_HEK293_Human0.90891861
133SMAD4_21741376_ChIP-Seq_EPCs_Human0.90551781
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89722677
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89611326
136* RUNX2_22187159_ChIP-Seq_PCA_Human0.89163827
137TP53_16413492_ChIP-PET_HCT116_Human0.89147318
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88943197
139POU5F1_16518401_ChIP-PET_MESCs_Mouse0.88097910
140GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.86410625
141* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.84308574
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83158536
143CBP_20019798_ChIP-Seq_JUKART_Human0.83158536

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting6.70097678
2MP0004859_abnormal_synaptic_plasticity5.18934651
3MP0003635_abnormal_synaptic_transmissio3.82327379
4MP0003123_paternal_imprinting3.46022198
5MP0003195_calcinosis3.32243721
6MP0005423_abnormal_somatic_nervous3.23964005
7MP0003880_abnormal_central_pattern3.22182315
8MP0004270_analgesia3.22058052
9* MP0009046_muscle_twitch3.08654573
10MP0002063_abnormal_learning/memory/cond3.04831595
11MP0009745_abnormal_behavioral_response2.97939238
12MP0002064_seizures2.82588530
13MP0002734_abnormal_mechanical_nocicepti2.79066366
14MP0003121_genomic_imprinting2.74895184
15* MP0005551_abnormal_eye_electrophysiolog2.65392533
16MP0001984_abnormal_olfaction2.62937882
17MP0001968_abnormal_touch/_nociception2.59917284
18MP0002822_catalepsy2.59528005
19MP0002572_abnormal_emotion/affect_behav2.54825255
20MP0001486_abnormal_startle_reflex2.53196389
21MP0002272_abnormal_nervous_system2.44959140
22MP0001666_abnormal_nutrient_absorption2.34815880
23MP0002735_abnormal_chemical_nociception2.28292504
24* MP0002067_abnormal_sensory_capabilities2.15491710
25MP0000566_synostosis2.13169666
26* MP0002184_abnormal_innervation2.11161821
27MP0003329_amyloid_beta_deposits2.10007514
28MP0000778_abnormal_nervous_system2.01963579
29MP0002736_abnormal_nociception_after1.89376847
30MP0001915_intracranial_hemorrhage1.86976373
31MP0010368_abnormal_lymphatic_system1.84452727
32MP0002090_abnormal_vision1.83689697
33MP0001440_abnormal_grooming_behavior1.82830515
34MP0005409_darkened_coat_color1.80897836
35MP0002557_abnormal_social/conspecific_i1.78946754
36MP0003879_abnormal_hair_cell1.77842465
37MP0010386_abnormal_urinary_bladder1.76238348
38* MP0008569_lethality_at_weaning1.75385384
39MP0005386_behavior/neurological_phenoty1.75193101
40MP0004924_abnormal_behavior1.75193101
41MP0002909_abnormal_adrenal_gland1.67347344
42MP0004885_abnormal_endolymph1.66862720
43MP0001501_abnormal_sleep_pattern1.66502407
44MP0002733_abnormal_thermal_nociception1.65847114
45MP0000955_abnormal_spinal_cord1.65701066
46MP0001502_abnormal_circadian_rhythm1.65628182
47* MP0004811_abnormal_neuron_physiology1.65383164
48MP0003172_abnormal_lysosome_physiology1.62860805
49MP0001970_abnormal_pain_threshold1.62760160
50* MP0002882_abnormal_neuron_morphology1.56121441
51MP0006072_abnormal_retinal_apoptosis1.50044779
52MP0005360_urolithiasis1.43499174
53MP0005408_hypopigmentation1.43315978
54MP0009780_abnormal_chondrocyte_physiolo1.43105728
55MP0005167_abnormal_blood-brain_barrier1.41665624
56MP0000534_abnormal_ureter_morphology1.38843536
57MP0003941_abnormal_skin_development1.37086124
58MP0003567_abnormal_fetal_cardiomyocyte1.37048212
59* MP0002066_abnormal_motor_capabilities/c1.36653225
60MP0005499_abnormal_olfactory_system1.35815412
61MP0005394_taste/olfaction_phenotype1.35815412
62MP0006054_spinal_hemorrhage1.35443308
63* MP0002229_neurodegeneration1.32881343
64MP0004858_abnormal_nervous_system1.31805778
65MP0003942_abnormal_urinary_system1.30795485
66MP0006276_abnormal_autonomic_nervous1.30619344
67MP0000639_abnormal_adrenal_gland1.26297044
68MP0002139_abnormal_hepatobiliary_system1.26231200
69MP0003868_abnormal_feces_composition1.25084078
70MP0004142_abnormal_muscle_tone1.24916877
71MP0003633_abnormal_nervous_system1.23822078
72MP0005253_abnormal_eye_physiology1.22037409
73MP0000569_abnormal_digit_pigmentation1.21528260
74MP0005257_abnormal_intraocular_pressure1.20065255
75MP0004233_abnormal_muscle_weight1.19363798
76MP0005187_abnormal_penis_morphology1.17496491
77MP0004742_abnormal_vestibular_system1.16135256
78MP0003631_nervous_system_phenotype1.15772023
79* MP0002152_abnormal_brain_morphology1.15042040
80MP0004272_abnormal_basement_membrane1.15030880
81MP0005085_abnormal_gallbladder_physiolo1.14925627
82MP0003115_abnormal_respiratory_system1.14867169
83MP0003632_abnormal_nervous_system1.14120963
84MP0005646_abnormal_pituitary_gland1.13251522
85MP0000604_amyloidosis1.13174829
86MP0005365_abnormal_bile_salt1.07469744
87* MP0002752_abnormal_somatic_nervous1.04300926
88MP0003385_abnormal_body_wall1.04292785
89MP0009384_cardiac_valve_regurgitation1.03776895
90MP0008872_abnormal_physiological_respon1.03462002
91* MP0005195_abnormal_posterior_eye1.03244894
92MP0001188_hyperpigmentation1.02901299
93MP0003878_abnormal_ear_physiology1.00172841
94MP0005377_hearing/vestibular/ear_phenot1.00172841
95MP0004145_abnormal_muscle_electrophysio1.00110349
96MP0001177_atelectasis0.99838903
97MP0008875_abnormal_xenobiotic_pharmacok0.99635249
98MP0003634_abnormal_glial_cell0.99275271
99MP0002938_white_spotting0.97340666
100MP0002118_abnormal_lipid_homeostasis0.94021055
101MP0001529_abnormal_vocalization0.92500328
102MP0002638_abnormal_pupillary_reflex0.91481187
103MP0003011_delayed_dark_adaptation0.91426134
104MP0003787_abnormal_imprinting0.90979828
105MP0003315_abnormal_perineum_morphology0.90648595
106MP0002069_abnormal_eating/drinking_beha0.90268941
107MP0002233_abnormal_nose_morphology0.88431625
108MP0000751_myopathy0.87272310
109MP0004085_abnormal_heartbeat0.86648887
110MP0001286_abnormal_eye_development0.86255948
111MP0003690_abnormal_glial_cell0.85424122
112MP0002160_abnormal_reproductive_system0.84897209
113MP0010329_abnormal_lipoprotein_level0.83870219
114MP0000631_abnormal_neuroendocrine_gland0.83207538
115MP0002697_abnormal_eye_size0.82949794
116MP0001270_distended_abdomen0.82697812
117MP0004215_abnormal_myocardial_fiber0.81728385
118MP0001299_abnormal_eye_distance/0.80817971
119MP0006292_abnormal_olfactory_placode0.80707471
120MP0008789_abnormal_olfactory_epithelium0.79345925
121MP0005248_abnormal_Harderian_gland0.77095774
122MP0000609_abnormal_liver_physiology0.76037368
123MP0001324_abnormal_eye_pigmentation0.75218138
124MP0000920_abnormal_myelination0.74573970
125MP0001293_anophthalmia0.73996639
126MP0005535_abnormal_body_temperature0.73709384
127MP0008874_decreased_physiological_sensi0.73371897
128MP0005084_abnormal_gallbladder_morpholo0.73274736
129MP0005058_abnormal_lysosome_morphology0.73208916
130MP0005220_abnormal_exocrine_pancreas0.73142191
131MP0003183_abnormal_peptide_metabolism0.72886873
132MP0003137_abnormal_impulse_conducting0.71938611
133MP0002092_abnormal_eye_morphology0.71132948
134MP0001963_abnormal_hearing_physiology0.71017303
135MP0005332_abnormal_amino_acid0.70340729
136MP0005645_abnormal_hypothalamus_physiol0.68956119
137MP0003119_abnormal_digestive_system0.68179416
138* MP0003861_abnormal_nervous_system0.67096700
139MP0003937_abnormal_limbs/digits/tail_de0.66672129
140MP0003890_abnormal_embryonic-extraembry0.64096011
141MP0002234_abnormal_pharynx_morphology0.61460038
142MP0002089_abnormal_postnatal_growth/wei0.58863605
143MP0003252_abnormal_bile_duct0.58636814
144* MP0010770_preweaning_lethality0.58416959
145* MP0002082_postnatal_lethality0.58416959

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)6.29022052
2Focal motor seizures (HP:0011153)5.28576369
3Congenital stationary night blindness (HP:0007642)5.04026780
4Hypobetalipoproteinemia (HP:0003563)4.82374131
5Joint hemorrhage (HP:0005261)4.82008568
6Myokymia (HP:0002411)4.77500615
7Abnormality of the common coagulation pathway (HP:0010990)4.76579429
8Complement deficiency (HP:0004431)4.73559773
9Action tremor (HP:0002345)4.71472996
10Progressive cerebellar ataxia (HP:0002073)4.63234008
11Epileptic encephalopathy (HP:0200134)4.63025989
12Focal seizures (HP:0007359)4.42897650
13Absence seizures (HP:0002121)4.17947964
14Visual hallucinations (HP:0002367)4.15525929
15Small epiphyses (HP:0010585)3.91864198
16Febrile seizures (HP:0002373)3.87398135
17Acanthocytosis (HP:0001927)3.85425886
18Hypercholesterolemia (HP:0003124)3.73468634
19Mutism (HP:0002300)3.71643923
20Generalized tonic-clonic seizures (HP:0002069)3.65671605
21Broad alveolar ridges (HP:0000187)3.60952576
22Glomerulonephritis (HP:0000099)3.58361243
23Dialeptic seizures (HP:0011146)3.53756498
24Dysdiadochokinesis (HP:0002075)3.51511487
25Central scotoma (HP:0000603)3.49124115
26Gaze-evoked nystagmus (HP:0000640)3.48079554
27Spontaneous abortion (HP:0005268)3.43373739
28Hemorrhage of the eye (HP:0011885)3.34644038
29Atonic seizures (HP:0010819)3.34299232
30Hyperventilation (HP:0002883)3.33531199
31EEG with generalized epileptiform discharges (HP:0011198)3.27056655
32Abnormality of carpal bone ossification (HP:0006257)3.26169279
33Epidermoid cyst (HP:0200040)3.25142884
34Menorrhagia (HP:0000132)3.23215494
35Hypolipoproteinemia (HP:0010981)3.21832727
36Xanthomatosis (HP:0000991)3.21597493
37Broad palm (HP:0001169)3.20837938
38Abnormality of complement system (HP:0005339)3.20150036
39Epileptiform EEG discharges (HP:0011182)3.20139134
40Supranuclear gaze palsy (HP:0000605)3.11938957
41Broad-based gait (HP:0002136)3.08855147
42Truncal ataxia (HP:0002078)3.07954128
43Excessive salivation (HP:0003781)3.07421931
44Drooling (HP:0002307)3.07421931
45Abnormality of aromatic amino acid family metabolism (HP:0004338)3.06446294
46Abnormality of the lower motor neuron (HP:0002366)3.05714677
47Impaired social interactions (HP:0000735)3.00512274
48Abnormal social behavior (HP:0012433)3.00512274
49Insidious onset (HP:0003587)2.99628461
50Termporal pattern (HP:0011008)2.99628461
51Hypophosphatemic rickets (HP:0004912)2.93471895
52Poor eye contact (HP:0000817)2.93285773
53Ankle clonus (HP:0011448)2.92595979
54Epiphyseal dysplasia (HP:0002656)2.90541699
55Alacrima (HP:0000522)2.89296668
56Depression (HP:0000716)2.88858509
57Abnormal tarsal ossification (HP:0008369)2.87985953
58Dysmetric saccades (HP:0000641)2.87924247
59Neurofibrillary tangles (HP:0002185)2.87466433
60Abnormality of macular pigmentation (HP:0008002)2.87212577
61Scanning speech (HP:0002168)2.82623913
62Genetic anticipation (HP:0003743)2.79913891
63Amyotrophic lateral sclerosis (HP:0007354)2.79281047
64Hemiparesis (HP:0001269)2.74833268
65Abnormality of the corticospinal tract (HP:0002492)2.74758378
66Intention tremor (HP:0002080)2.71902674
67Flat acetabular roof (HP:0003180)2.71137371
68Hypsarrhythmia (HP:0002521)2.69902942
69Asymmetry of the thorax (HP:0001555)2.66967204
70Status epilepticus (HP:0002133)2.66139798
71Dysmetria (HP:0001310)2.65561321
72Pancreatic islet-cell hyperplasia (HP:0004510)2.63470961
73Cerebral inclusion bodies (HP:0100314)2.61525190
74Abnormality of the lumbar spine (HP:0100712)2.60414722
75Urinary bladder sphincter dysfunction (HP:0002839)2.59922791
76Torticollis (HP:0000473)2.58003294
77Hemiplegia (HP:0002301)2.55867253
78Postural instability (HP:0002172)2.50486780
79Abnormal hand bone ossification (HP:0010660)2.50290658
80Progressive inability to walk (HP:0002505)2.50244380
81Papillary thyroid carcinoma (HP:0002895)2.48664191
82Abnormality of the nasal septum (HP:0000419)2.47327615
83Abnormal ossification of hand bones (HP:0005921)2.45594163
84Abnormality of the wing of the ilium (HP:0011867)2.45450721
85Anxiety (HP:0000739)2.44886146
86Abnormality of binocular vision (HP:0011514)2.44683140
87Diplopia (HP:0000651)2.44683140
88Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.44535617
89Spastic gait (HP:0002064)2.43557266
90Arthropathy (HP:0003040)2.43521383
91Vitreoretinal degeneration (HP:0000655)2.43504870
92Osteomalacia (HP:0002749)2.42708948
93Decreased central vision (HP:0007663)2.40366766
94Vascular calcification (HP:0004934)2.40245295
95Impaired vibration sensation in the lower limbs (HP:0002166)2.40203593
96Impaired smooth pursuit (HP:0007772)2.39275209
97Diastasis recti (HP:0001540)2.38372672
98Irregular epiphyses (HP:0010582)2.37436897
99Abnormality of ocular smooth pursuit (HP:0000617)2.36975137
100Impaired pain sensation (HP:0007328)2.35735564
101Abnormality of pain sensation (HP:0010832)2.35735564
102Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34663012
103Abnormal eating behavior (HP:0100738)2.33436448
104Flared iliac wings (HP:0002869)2.31602760
105Tetraplegia (HP:0002445)2.29494837
106Polyphagia (HP:0002591)2.28255306
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.27790862
108Focal dystonia (HP:0004373)2.24247726
109Absent speech (HP:0001344)2.23897370
110Morphological abnormality of the pyramidal tract (HP:0002062)2.23405075
111Scotoma (HP:0000575)2.22081871
112Decreased lacrimation (HP:0000633)2.21416535
113Vaginal fistula (HP:0004320)2.21332546
114Facial shape deformation (HP:0011334)2.19184607
115Potter facies (HP:0002009)2.19184607
116Conjugated hyperbilirubinemia (HP:0002908)2.18837753
117Systemic lupus erythematosus (HP:0002725)2.17345915
118Cholecystitis (HP:0001082)2.17066469
119Abnormal gallbladder physiology (HP:0012438)2.17066469
120Limited elbow extension (HP:0001377)2.16577893
121Hypoalphalipoproteinemia (HP:0003233)2.13344297
122Gait imbalance (HP:0002141)2.12971105
123Agitation (HP:0000713)2.12164156
124Inability to walk (HP:0002540)2.11382916
125Urinary urgency (HP:0000012)2.10953768
126Supernumerary spleens (HP:0009799)2.10416914
127Craniofacial dystonia (HP:0012179)2.09437237
128Renal duplication (HP:0000075)2.09211929
129Clonus (HP:0002169)2.09154039
130Intrahepatic cholestasis (HP:0001406)2.09107792
131Increased serum pyruvate (HP:0003542)2.08516086
132Deep venous thrombosis (HP:0002625)2.08209546
133Skin nodule (HP:0200036)2.07026706
134Cardiovascular calcification (HP:0011915)2.06986990
135Akinesia (HP:0002304)2.06799536
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.06213128
137Absent epiphyses (HP:0010577)2.06213128
138Abnormality of glycolysis (HP:0004366)2.06095545
139Hepatoblastoma (HP:0002884)2.03313481
140Abnormality of the pubic bones (HP:0003172)2.02602861
141Enlarged kidneys (HP:0000105)2.01861275
142Gingival bleeding (HP:0000225)2.01600787
143Inappropriate behavior (HP:0000719)2.01085888
144Megalencephaly (HP:0001355)2.00154144
145Neuronal loss in central nervous system (HP:0002529)2.00109695
146Spastic tetraplegia (HP:0002510)1.99865192
147Bradykinesia (HP:0002067)1.99475902
148Abnormality of the intrinsic pathway (HP:0010989)1.99461864
149Mitral stenosis (HP:0001718)1.99296637
150Protrusio acetabuli (HP:0003179)1.97711132
151Generalized myoclonic seizures (HP:0002123)1.97626853
152Hypothermia (HP:0002045)1.97234951
153Aqueductal stenosis (HP:0002410)1.96714026
154Insomnia (HP:0100785)1.94787591
155Lower limb muscle weakness (HP:0007340)1.94204028
156Increased corneal curvature (HP:0100692)1.93925872
157Keratoconus (HP:0000563)1.93925872
158Gait ataxia (HP:0002066)1.93639637
159Heterotopia (HP:0002282)1.92977673
160Postural tremor (HP:0002174)1.92066259
161Poikilocytosis (HP:0004447)1.91688980
162Partial agenesis of the corpus callosum (HP:0001338)1.90247584
163Amblyopia (HP:0000646)1.89320921
164Hepatocellular carcinoma (HP:0001402)1.87179593
165Abnormal rod and cone electroretinograms (HP:0008323)1.87108357
166Severe visual impairment (HP:0001141)1.84737612
167Purpura (HP:0000979)1.84716663
168Stereotypic behavior (HP:0000733)1.84259207
169Exotropia (HP:0000577)1.83148946
170Abnormality of salivation (HP:0100755)1.81726592
171Arterial tortuosity (HP:0005116)1.80748386
172Cupped ribs (HP:0000887)1.80565958
173Widely spaced teeth (HP:0000687)1.79893862
174Midline defect of the nose (HP:0004122)1.78108287
175Abnormality of the acetabulum (HP:0003170)1.77353105
176Prolonged QT interval (HP:0001657)1.77245637
177Limb dystonia (HP:0002451)1.77080109
178Wide nose (HP:0000445)1.76409360
179Neonatal short-limb short stature (HP:0008921)1.74645673
180Blue irides (HP:0000635)1.74643486
181Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74642940
182Abnormality of saccadic eye movements (HP:0000570)1.73088499
183Thrombophlebitis (HP:0004418)1.71048717
184Submucous cleft hard palate (HP:0000176)1.68460242
185Rickets (HP:0002748)1.66886612
186Abnormal foot bone ossification (HP:0010675)1.66002226
187Fat malabsorption (HP:0002630)1.65586125
188Abnormality of the lacrimal duct (HP:0011481)1.64518539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.79853983
2FGFR44.46466641
3FGFR33.81754008
4MAP3K43.50920375
5MAP3K93.10991596
6WNK42.99084316
7NTRK32.98490512
8PAK62.66687493
9MINK12.64843821
10MAP2K72.64627952
11PDGFRA2.56295348
12PKN22.50112941
13EPHA42.46023951
14CDK122.28001488
15AKT32.26325588
16NTRK22.19735484
17PIK3CA2.02890710
18DAPK22.02194091
19PHKG12.01818164
20PHKG22.01818164
21PBK2.00771985
22MAP2K41.99942305
23FGFR11.92884816
24CASK1.87524164
25CAMKK11.76624214
26BCR1.76201958
27RIPK11.65921251
28PRPF4B1.60667896
29MAPK131.60425365
30LATS11.58525709
31SIK21.53085773
32KSR11.43095591
33DYRK1B1.42567600
34STK381.38867253
35CDK51.38614611
36TNIK1.36962403
37NTRK11.36359299
38DDR21.29739074
39KSR21.28657481
40PRKD31.26520391
41DYRK1A1.24414661
42PKN11.21319542
43NEK11.15922170
44CAMKK21.12079116
45PRKCG1.11857597
46FES1.11155015
47SGK4941.10395611
48SGK2231.10395611
49MAP3K61.07490776
50CAMK1G1.07280128
51OBSCN1.05501900
52EEF2K1.01420229
53MARK21.01161834
54ERBB30.98869412
55RET0.94785775
56SGK20.94624361
57DYRK20.92929708
58FLT30.92470562
59PLK20.91006459
60LATS20.89921158
61CSNK1G20.89565188
62PINK10.87608741
63CDK150.86893272
64CDK140.86523158
65STK110.86152323
66SCYL20.84729261
67PRKCZ0.84593923
68CDK180.84417430
69PNCK0.82357210
70PRKAA10.81048202
71PAK30.78564408
72ERBB40.77850262
73INSRR0.77708786
74GRK50.77259661
75CAMK2A0.76240386
76TAOK20.76167863
77DAPK10.75983810
78BRD40.75121746
79CSNK1E0.73853332
80SGK30.73522533
81CDK11A0.72278732
82UHMK10.71990268
83PRKCH0.71615022
84CAMK10.70548579
85TGFBR20.68822635
86MAP3K130.68650046
87PRKAA20.68364309
88RPS6KB10.67995871
89STK390.67212823
90MAP3K70.67196442
91PDK10.66856620
92TRIB30.66436116
93PDPK10.66215312
94NEK20.64701816
95TAOK10.64277353
96PRKCE0.63049516
97PDGFRB0.62398932
98SGK10.61924445
99EPHA30.60995330
100TYRO30.60885679
101ERBB20.60779745
102MAPK120.58907328
103BRSK10.56696161
104RPS6KA30.55958063
105CAMK1D0.55077460
106CAMK2D0.53940569
107FGR0.53667260
108ALK0.52188538
109FGFR20.51671078
110FYN0.51126614
111FER0.50131925
112CDK30.49018025
113CDC42BPA0.47344891
114PRKG10.45750879
115RPS6KA20.45521064
116CSNK1D0.45520452
117CAMK40.44960019
118MAP3K20.44906273
119PRKCB0.44558146
120WNK10.42406987
121CSNK1A1L0.42288146
122ICK0.39914971
123MTOR0.39710074
124MAPK110.39322149
125MAPK100.39252583
126SRC0.39019280
127CAMK2B0.38739084
128MAPK90.37786415
129ROCK20.37528039
130CSNK1G30.37512284
131MAPK80.37127772
132IRAK20.34387252
133WNK30.34233127
134PTK20.33181646
135PRKACG0.33104089
136GSK3B0.30435025
137STK38L0.27513033
138MAP3K50.26972809
139CDK10.24422127

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.80614552
2GABAergic synapse_Homo sapiens_hsa047273.23600197
3Synaptic vesicle cycle_Homo sapiens_hsa047213.22558580
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81037370
5Morphine addiction_Homo sapiens_hsa050322.70458873
6Fatty acid biosynthesis_Homo sapiens_hsa000612.55122408
7Circadian entrainment_Homo sapiens_hsa047132.48883226
8Steroid biosynthesis_Homo sapiens_hsa001002.48381021
9Glutamatergic synapse_Homo sapiens_hsa047242.48100112
10Fat digestion and absorption_Homo sapiens_hsa049752.33516820
11Olfactory transduction_Homo sapiens_hsa047402.10248205
12Salivary secretion_Homo sapiens_hsa049701.90773230
13Taste transduction_Homo sapiens_hsa047421.83578617
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83089673
15Nitrogen metabolism_Homo sapiens_hsa009101.82107319
16Dopaminergic synapse_Homo sapiens_hsa047281.81761711
17Insulin secretion_Homo sapiens_hsa049111.80351847
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.80123792
19Cholinergic synapse_Homo sapiens_hsa047251.77749803
20Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.75800886
21Long-term potentiation_Homo sapiens_hsa047201.73571987
22Histidine metabolism_Homo sapiens_hsa003401.63694045
23PPAR signaling pathway_Homo sapiens_hsa033201.57924617
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56847410
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56028374
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55067160
27Butanoate metabolism_Homo sapiens_hsa006501.54905455
28Vitamin digestion and absorption_Homo sapiens_hsa049771.53064426
29Fatty acid degradation_Homo sapiens_hsa000711.51841825
30Renin secretion_Homo sapiens_hsa049241.51492895
31Amphetamine addiction_Homo sapiens_hsa050311.47951666
32Phenylalanine metabolism_Homo sapiens_hsa003601.43467119
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43324506
34Serotonergic synapse_Homo sapiens_hsa047261.39873981
35Type II diabetes mellitus_Homo sapiens_hsa049301.38989598
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38798936
37Long-term depression_Homo sapiens_hsa047301.33773196
38Oxytocin signaling pathway_Homo sapiens_hsa049211.31916812
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.30175951
40Gastric acid secretion_Homo sapiens_hsa049711.29116045
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.28012872
42Bile secretion_Homo sapiens_hsa049761.27450880
43Starch and sucrose metabolism_Homo sapiens_hsa005001.26880327
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25383652
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22746634
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.22621879
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20147748
48Phototransduction_Homo sapiens_hsa047441.20079366
49Arginine biosynthesis_Homo sapiens_hsa002201.19259604
50Cocaine addiction_Homo sapiens_hsa050301.18637254
51Vitamin B6 metabolism_Homo sapiens_hsa007501.17240007
52Calcium signaling pathway_Homo sapiens_hsa040201.13880062
53Arginine and proline metabolism_Homo sapiens_hsa003301.13084961
54Axon guidance_Homo sapiens_hsa043601.12485121
55Gap junction_Homo sapiens_hsa045401.09584191
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.05556170
57Tyrosine metabolism_Homo sapiens_hsa003500.97691775
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96025043
59cAMP signaling pathway_Homo sapiens_hsa040240.95653388
60GnRH signaling pathway_Homo sapiens_hsa049120.94332158
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93898747
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91763529
63Estrogen signaling pathway_Homo sapiens_hsa049150.87072156
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86992833
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84946719
66Lysine degradation_Homo sapiens_hsa003100.84877532
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81172339
68Collecting duct acid secretion_Homo sapiens_hsa049660.80648575
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80029507
70N-Glycan biosynthesis_Homo sapiens_hsa005100.78973423
71Propanoate metabolism_Homo sapiens_hsa006400.78146415
72ErbB signaling pathway_Homo sapiens_hsa040120.77965654
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77624090
74Staphylococcus aureus infection_Homo sapiens_hsa051500.76859254
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76853346
76Biosynthesis of amino acids_Homo sapiens_hsa012300.75919955
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75403982
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73278790
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72643772
80Renin-angiotensin system_Homo sapiens_hsa046140.72531516
81Circadian rhythm_Homo sapiens_hsa047100.71113499
82Vascular smooth muscle contraction_Homo sapiens_hsa042700.69012224
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.69001954
84Glioma_Homo sapiens_hsa052140.66862070
85Alcoholism_Homo sapiens_hsa050340.66682719
86Dilated cardiomyopathy_Homo sapiens_hsa054140.65910432
87Pancreatic secretion_Homo sapiens_hsa049720.65613709
88Other glycan degradation_Homo sapiens_hsa005110.65003723
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.63272305
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62192280
91Cardiac muscle contraction_Homo sapiens_hsa042600.62140455
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61871237
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.59919025
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59588822
95Thyroid hormone synthesis_Homo sapiens_hsa049180.59551807
96Wnt signaling pathway_Homo sapiens_hsa043100.59229767
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.59036116
98Adherens junction_Homo sapiens_hsa045200.58983506
99Fructose and mannose metabolism_Homo sapiens_hsa000510.58221546
100Endometrial cancer_Homo sapiens_hsa052130.57981883
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57930842
102* ECM-receptor interaction_Homo sapiens_hsa045120.57930823
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57612953
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56744732
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56441680
106Retinol metabolism_Homo sapiens_hsa008300.55071132
107Melanogenesis_Homo sapiens_hsa049160.53103720
108Choline metabolism in cancer_Homo sapiens_hsa052310.51402912
109Hippo signaling pathway_Homo sapiens_hsa043900.50833079
110Glucagon signaling pathway_Homo sapiens_hsa049220.50261950
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49858414
112mTOR signaling pathway_Homo sapiens_hsa041500.49379687
113Peroxisome_Homo sapiens_hsa041460.48529693
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47498195
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47159918
116Complement and coagulation cascades_Homo sapiens_hsa046100.47007029
117Non-small cell lung cancer_Homo sapiens_hsa052230.46174025
118Pyruvate metabolism_Homo sapiens_hsa006200.45813508
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44267186
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.43920888
121MAPK signaling pathway_Homo sapiens_hsa040100.42479634
122Insulin resistance_Homo sapiens_hsa049310.40897780
123HIF-1 signaling pathway_Homo sapiens_hsa040660.40700228
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40350239
125ABC transporters_Homo sapiens_hsa020100.38745515
126beta-Alanine metabolism_Homo sapiens_hsa004100.38202934
127Ovarian steroidogenesis_Homo sapiens_hsa049130.38038060
128Colorectal cancer_Homo sapiens_hsa052100.37680334
129Inositol phosphate metabolism_Homo sapiens_hsa005620.37161396
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36926216
131Oocyte meiosis_Homo sapiens_hsa041140.34419907
132Insulin signaling pathway_Homo sapiens_hsa049100.34272239
133AMPK signaling pathway_Homo sapiens_hsa041520.33687011
134Ras signaling pathway_Homo sapiens_hsa040140.33596058
135Dorso-ventral axis formation_Homo sapiens_hsa043200.33200373
136Glycerolipid metabolism_Homo sapiens_hsa005610.33079896
137Prion diseases_Homo sapiens_hsa050200.31344646
138Tryptophan metabolism_Homo sapiens_hsa003800.31141689
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30765042
140Renal cell carcinoma_Homo sapiens_hsa052110.30692220
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29128805
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28659787
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27965884
144Fatty acid metabolism_Homo sapiens_hsa012120.26573865
145Sphingolipid signaling pathway_Homo sapiens_hsa040710.26524633

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