RELT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.78229442
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.76193388
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.76193388
4response to peptidoglycan (GO:0032494)5.64182743
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.25789713
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.25789713
7modulation by symbiont of host immune response (GO:0052553)5.25789713
8positive regulation by symbiont of host defense response (GO:0052509)5.25789713
9modulation by symbiont of host defense response (GO:0052031)5.25789713
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.25789713
11ribosomal small subunit assembly (GO:0000028)4.76840511
12NIK/NF-kappaB signaling (GO:0038061)4.69335568
13macrophage activation involved in immune response (GO:0002281)4.67532647
14negative regulation of interleukin-12 production (GO:0032695)4.63726915
15detection of other organism (GO:0098543)4.62954244
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.46856501
17detection of bacterium (GO:0016045)4.42127720
18positive regulation of gamma-delta T cell activation (GO:0046645)4.42114699
19viral transcription (GO:0019083)4.17489860
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.03967868
21regulation of mast cell degranulation (GO:0043304)3.97941862
22translational termination (GO:0006415)3.96244230
23negative thymic T cell selection (GO:0045060)3.95244757
24detection of external biotic stimulus (GO:0098581)3.94964645
25detection of molecule of bacterial origin (GO:0032490)3.94835706
26positive regulation of B cell differentiation (GO:0045579)3.87730781
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83826815
28SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77392602
29leukocyte aggregation (GO:0070486)3.76076388
30regulation of interferon-beta biosynthetic process (GO:0045357)3.75946350
31negative T cell selection (GO:0043383)3.74562859
32myeloid cell activation involved in immune response (GO:0002275)3.72688430
33antigen processing and presentation via MHC class Ib (GO:0002475)3.70812598
34protein targeting to ER (GO:0045047)3.68658909
35regulation of T-helper 1 cell differentiation (GO:0045625)3.67904499
36cotranslational protein targeting to membrane (GO:0006613)3.67324218
37regulation of mast cell activation involved in immune response (GO:0033006)3.64245584
38response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62944412
39response to host immune response (GO:0052572)3.62944412
40detection of biotic stimulus (GO:0009595)3.62207965
41regulation of myeloid leukocyte mediated immunity (GO:0002886)3.61548466
42ribosomal small subunit biogenesis (GO:0042274)3.60122760
43regulation of B cell differentiation (GO:0045577)3.57408095
44positive regulation of mast cell activation (GO:0033005)3.55580359
45germinal center formation (GO:0002467)3.55038836
46macrophage activation (GO:0042116)3.53834874
47regulation of leukocyte degranulation (GO:0043300)3.53520523
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.53468446
49myeloid dendritic cell activation (GO:0001773)3.51585064
50establishment of protein localization to endoplasmic reticulum (GO:0072599)3.51577738
51translational elongation (GO:0006414)3.51292724
52microglial cell activation (GO:0001774)3.51185749
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.50445748
54regulation of mast cell activation (GO:0033003)3.46855183
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.44950540
56protein localization to endoplasmic reticulum (GO:0070972)3.43853301
57neutrophil mediated immunity (GO:0002446)3.42666833
58negative regulation of T cell mediated immunity (GO:0002710)3.40641458
59response to host (GO:0075136)3.40270123
60response to host defenses (GO:0052200)3.40270123
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40270123
62myeloid dendritic cell differentiation (GO:0043011)3.39218077
63regulation of B cell receptor signaling pathway (GO:0050855)3.37866501
64regulation of interleukin-12 biosynthetic process (GO:0045075)3.36958622
65negative regulation of erythrocyte differentiation (GO:0045647)3.33177316
66B cell receptor signaling pathway (GO:0050853)3.33100344
67positive regulation of mast cell degranulation (GO:0043306)3.23079574
68positive regulation of mast cell activation involved in immune response (GO:0033008)3.23079574
69negative regulation of leukocyte mediated immunity (GO:0002704)3.22681388
70positive regulation of antigen processing and presentation (GO:0002579)3.21429184
71regulation of gamma-delta T cell differentiation (GO:0045586)3.21329079
72negative regulation of necroptotic process (GO:0060546)3.19731077
73response to muramyl dipeptide (GO:0032495)3.16906297
74viral life cycle (GO:0019058)3.16680353
75negative regulation of phagocytosis (GO:0050765)3.16466174
76positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.14331939
77B cell mediated immunity (GO:0019724)3.13903558
78regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12971647
79T cell migration (GO:0072678)3.12563502
80regulation of necroptotic process (GO:0060544)3.11658476
81regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09955656
82response to interleukin-15 (GO:0070672)3.09739526
83positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.09470358
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.09329598
85T cell homeostasis (GO:0043029)3.09007056
86leukocyte degranulation (GO:0043299)3.06760159
87cellular protein complex disassembly (GO:0043624)3.04111273
88immunoglobulin mediated immune response (GO:0016064)3.01424784
89regulation of T-helper 2 cell differentiation (GO:0045628)3.00571520
90dendritic cell differentiation (GO:0097028)2.96729661
91mature B cell differentiation (GO:0002335)2.94816738
92negative regulation of interleukin-6 production (GO:0032715)2.94521740
93thymic T cell selection (GO:0045061)2.93609683
94regulation of tolerance induction (GO:0002643)2.93428196
95regulation of gamma-delta T cell activation (GO:0046643)2.93352103
96negative regulation of cytokine production involved in immune response (GO:0002719)2.93144842
97regulation of antigen processing and presentation (GO:0002577)2.93057369
98JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.93057007
99tolerance induction (GO:0002507)2.92841201
100myeloid leukocyte mediated immunity (GO:0002444)2.90385410
101necroptotic process (GO:0070266)2.90171239
102regulation of regulated secretory pathway (GO:1903305)2.89435627
103megakaryocyte development (GO:0035855)2.88422451
104negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88108598
105T-helper 1 type immune response (GO:0042088)2.87880382
106respiratory burst (GO:0045730)2.87274069
107negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87205676
108negative regulation of cell killing (GO:0031342)2.87205676
109interferon-gamma-mediated signaling pathway (GO:0060333)2.86808565
110production of molecular mediator involved in inflammatory response (GO:0002532)2.86314076
111leukocyte migration involved in inflammatory response (GO:0002523)2.85132680
112regulation of T cell tolerance induction (GO:0002664)2.84956120
113myeloid leukocyte activation (GO:0002274)2.83938104
114positive regulation of interferon-alpha production (GO:0032727)2.83820052
115positive regulation of cellular amide metabolic process (GO:0034250)2.83390608
116neutrophil activation (GO:0042119)2.81695444
117positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80762728
118translational initiation (GO:0006413)2.80615542
119negative regulation of innate immune response (GO:0045824)2.79713842
120negative regulation of toll-like receptor signaling pathway (GO:0034122)2.79291719
121neutrophil activation involved in immune response (GO:0002283)2.78238750
122natural killer cell differentiation (GO:0001779)2.77148838
123T cell apoptotic process (GO:0070231)2.76916753
124regulation of RIG-I signaling pathway (GO:0039535)2.76831328
125response to interferon-beta (GO:0035456)2.76496497
126defense response to protozoan (GO:0042832)2.76330949
127regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.76324258
128mature B cell differentiation involved in immune response (GO:0002313)2.75764499
129response to type I interferon (GO:0034340)2.75469015
130positive thymic T cell selection (GO:0045059)2.75156747
131cellular response to type I interferon (GO:0071357)2.74394796
132type I interferon signaling pathway (GO:0060337)2.74394796
133regulation of alpha-beta T cell proliferation (GO:0046640)2.73261718
134positive regulation of lamellipodium assembly (GO:0010592)2.73251901
135folic acid-containing compound biosynthetic process (GO:0009396)2.73169320
136protein complex disassembly (GO:0043241)2.71219658
137natural killer cell activation (GO:0030101)2.70816751
138regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.69399767
139granulocyte activation (GO:0036230)2.68905655
140cellular response to interleukin-15 (GO:0071350)2.67924021
141positive regulation of macrophage differentiation (GO:0045651)2.66745228
142positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66245806
143regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.65903645
144positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.65673011
145cellular response to interferon-beta (GO:0035458)2.65415155
146leukocyte homeostasis (GO:0001776)2.62498929
147regulation of T cell receptor signaling pathway (GO:0050856)2.61625699
148maturation of SSU-rRNA (GO:0030490)2.61077453
149actin nucleation (GO:0045010)2.60835072
150T cell selection (GO:0045058)2.60242785
151lymphocyte homeostasis (GO:0002260)2.59502514
152chaperone mediated protein folding requiring cofactor (GO:0051085)2.59028473
153positive regulation of T-helper cell differentiation (GO:0045624)2.58722101
154lymph node development (GO:0048535)2.58609039
155response to protozoan (GO:0001562)2.56866944
156regulation of type I interferon-mediated signaling pathway (GO:0060338)2.56668762
157T cell proliferation (GO:0042098)2.56487195
158negative regulation of necrotic cell death (GO:0060547)2.53788674
159cellular extravasation (GO:0045123)2.53003429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.78683027
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.36396850
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.34960457
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27404044
5* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27197751
6MYC_22102868_ChIP-Seq_BL_Human3.12755059
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09715465
8VDR_21846776_ChIP-Seq_THP-1_Human3.01114612
9SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89476559
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.74108488
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.71296337
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.70288314
13SCL_19346495_ChIP-Seq_HPC-7_Human2.58857479
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51548712
15* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42356711
16* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.36218620
17* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.31444061
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31285858
19* SPI1_23547873_ChIP-Seq_NB4_Human2.22063385
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.17260990
21* MAF_26560356_Chip-Seq_TH1_Human2.16832397
22* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.14051506
23MYB_26560356_Chip-Seq_TH2_Human2.08368658
24* VDR_24763502_ChIP-Seq_THP-1_Human2.07209426
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.05502716
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.99911760
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97336383
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.94349266
29* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.93712210
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91091332
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.89518593
32UTX_26944678_Chip-Seq_JUKART_Human1.88620734
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.87185907
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85151089
35MYB_26560356_Chip-Seq_TH1_Human1.84192216
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.83577110
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79286552
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.76966099
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.75637814
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75617036
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.70384423
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70276351
43ERG_20887958_ChIP-Seq_HPC-7_Mouse1.68997011
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.68594013
45CIITA_25753668_ChIP-Seq_RAJI_Human1.68066412
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67383556
47* VDR_24787735_ChIP-Seq_THP-1_Human1.64816759
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64521691
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.64379342
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.64029420
51* VDR_23849224_ChIP-Seq_CD4+_Human1.63982263
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60059207
53LXR_22292898_ChIP-Seq_THP-1_Human1.59932065
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.59417029
55STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57321074
56XRN2_22483619_ChIP-Seq_HELA_Human1.53939646
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52408319
58CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51248613
59* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.50695888
60SPI1_23127762_ChIP-Seq_K562_Human1.49187320
61MYC_18358816_ChIP-ChIP_MESCs_Mouse1.47813797
62* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47089928
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.46780134
64* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.46627212
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46352703
66MAF_26560356_Chip-Seq_TH2_Human1.45323214
67BP1_19119308_ChIP-ChIP_Hs578T_Human1.44747110
68ETS1_20019798_ChIP-Seq_JURKAT_Human1.44180330
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.43617347
70RUNX_20019798_ChIP-Seq_JUKART_Human1.42764318
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42598480
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42195457
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.41126362
74GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41032882
75GATA1_22025678_ChIP-Seq_K562_Human1.40999592
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40507192
77THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39617937
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39007637
79FOXP3_21729870_ChIP-Seq_TREG_Human1.37041497
80JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36387287
81HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34716878
82* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34386891
83GATA3_27048872_Chip-Seq_THYMUS_Human1.33479979
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32767510
85* KDM2B_26808549_Chip-Seq_JURKAT_Human1.31830250
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31150285
87KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30985880
88* GATA1_19941827_ChIP-Seq_MEL_Mouse1.30322036
89* KDM2B_26808549_Chip-Seq_DND41_Human1.26220785
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25043709
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23006248
92MYC_19030024_ChIP-ChIP_MESCs_Mouse1.22929772
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21994510
94TFEB_21752829_ChIP-Seq_HELA_Human1.21646885
95CREB1_15753290_ChIP-ChIP_HEK293T_Human1.21138194
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19163717
97* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18762925
98CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17263405
99NCOR1_26117541_ChIP-Seq_K562_Human1.17044288
100DCP1A_22483619_ChIP-Seq_HELA_Human1.15206148
101GABP_19822575_ChIP-Seq_HepG2_Human1.15056215
102NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14658015
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14129063
104FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12957145
105RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11520254
106* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10598745
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10015873
108GATA1_19941826_ChIP-Seq_K562_Human1.08792100
109PU.1_20513432_ChIP-Seq_Bcells_Mouse1.08559461
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07367926
111BCOR_27268052_Chip-Seq_Bcells_Human1.06844381
112STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05992768
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04605977
114CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03964708
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.03347084
116NELFA_20434984_ChIP-Seq_ESCs_Mouse1.03057550
117* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02979998
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01662090
119GATA3_26560356_Chip-Seq_TH2_Human1.00680336
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00628070
121* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00385506
122TTF2_22483619_ChIP-Seq_HELA_Human0.99998435
123BCL6_27268052_Chip-Seq_Bcells_Human0.98326703
124PU_27001747_Chip-Seq_BMDM_Mouse0.97919909
125THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97716373
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.96597401
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96317142
128ELF1_20517297_ChIP-Seq_JURKAT_Human0.94785610
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94177817
130* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93157412
131KDM2B_26808549_Chip-Seq_K562_Human0.89462444
132* RACK7_27058665_Chip-Seq_MCF-7_Human0.89088573
133GATA2_19941826_ChIP-Seq_K562_Human0.88495406
134* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85574698
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.84722256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system4.29214657
2MP0001835_abnormal_antigen_presentation4.09315496
3MP0005671_abnormal_response_to3.18591987
4MP0002396_abnormal_hematopoietic_system2.94101181
5MP0001790_abnormal_immune_system2.88980959
6MP0005387_immune_system_phenotype2.88980959
7MP0003436_decreased_susceptibility_to2.85987269
8MP0001800_abnormal_humoral_immune2.76784502
9MP0003763_abnormal_thymus_physiology2.74073268
10MP0001348_abnormal_lacrimal_gland2.64128840
11MP0005000_abnormal_immune_tolerance2.62697747
12MP0003303_peritoneal_inflammation2.53794415
13MP0002398_abnormal_bone_marrow2.51075695
14MP0002452_abnormal_antigen_presenting2.50195081
15MP0002420_abnormal_adaptive_immunity2.47361793
16MP0001819_abnormal_immune_cell2.45553212
17MP0009785_altered_susceptibility_to2.44419767
18MP0002723_abnormal_immune_serum2.43520228
19MP0002877_abnormal_melanocyte_morpholog2.36544684
20MP0002148_abnormal_hypersensitivity_rea2.36494412
21MP0005025_abnormal_response_to2.27472281
22MP0002166_altered_tumor_susceptibility2.27327232
23MP0004510_myositis2.19330113
24MP0000716_abnormal_immune_system2.18181266
25MP0005310_abnormal_salivary_gland2.14264906
26MP0002419_abnormal_innate_immunity2.13268330
27MP0004808_abnormal_hematopoietic_stem2.09647082
28MP0000689_abnormal_spleen_morphology2.02232902
29MP0009333_abnormal_splenocyte_physiolog2.00048382
30MP0002722_abnormal_immune_system1.98186857
31MP0002163_abnormal_gland_morphology1.98005328
32MP0001853_heart_inflammation1.97684735
33MP0005464_abnormal_platelet_physiology1.94312684
34MP0008260_abnormal_autophagy1.92855053
35MP0002405_respiratory_system_inflammati1.92698672
36MP0001545_abnormal_hematopoietic_system1.92120263
37MP0005397_hematopoietic_system_phenotyp1.92120263
38MP0002429_abnormal_blood_cell1.91331450
39MP0003828_pulmonary_edema1.89309587
40MP0005451_abnormal_body_composition1.88021419
41MP0003300_gastrointestinal_ulcer1.77784564
42MP0000703_abnormal_thymus_morphology1.76614392
43MP0003183_abnormal_peptide_metabolism1.69917730
44MP0001873_stomach_inflammation1.69522789
45MP0003866_abnormal_defecation1.69303061
46MP0002006_tumorigenesis1.68505841
47MP0003656_abnormal_erythrocyte_physiolo1.67760209
48MP0006082_CNS_inflammation1.59823769
49MP0002254_reproductive_system_inflammat1.59761938
50MP0010155_abnormal_intestine_physiology1.58804519
51MP0005379_endocrine/exocrine_gland_phen1.55243586
52MP0008057_abnormal_DNA_replication1.53784447
53MP0002998_abnormal_bone_remodeling1.51860645
54MP0001845_abnormal_inflammatory_respons1.49672978
55MP0005174_abnormal_tail_pigmentation1.49221857
56MP0002138_abnormal_hepatobiliary_system1.48520850
57MP0000490_abnormal_crypts_of1.47111640
58MP0009840_abnormal_foam_cell1.44079390
59MP0008007_abnormal_cellular_replicative1.32460983
60MP0001986_abnormal_taste_sensitivity1.32053892
61MP0003172_abnormal_lysosome_physiology1.31962241
62MP0002132_abnormal_respiratory_system1.29296623
63MP0001851_eye_inflammation1.27671381
64MP0004947_skin_inflammation1.27656116
65MP0002933_joint_inflammation1.18718394
66MP0001533_abnormal_skeleton_physiology1.16774221
67MP0003724_increased_susceptibility_to1.12549772
68MP0009278_abnormal_bone_marrow1.12272579
69MP0000465_gastrointestinal_hemorrhage1.10865269
70MP0002693_abnormal_pancreas_physiology1.08709623
71MP0005058_abnormal_lysosome_morphology1.08518124
72MP0004381_abnormal_hair_follicle1.07655274
73MP0004883_abnormal_blood_vessel1.07005697
74MP0005166_decreased_susceptibility_to1.06674655
75MP0000858_altered_metastatic_potential1.05831235
76MP0008469_abnormal_protein_level1.04191787
77MP0003693_abnormal_embryo_hatching1.03902349
78MP0010094_abnormal_chromosome_stability1.03745664
79MP0000604_amyloidosis1.03097860
80MP0008004_abnormal_stomach_pH1.02784390
81MP0003077_abnormal_cell_cycle1.01077915
82MP0002019_abnormal_tumor_incidence0.99690434
83MP0010307_abnormal_tumor_latency0.99490637
84MP0005075_abnormal_melanosome_morpholog0.97221041
85MP0003690_abnormal_glial_cell0.96510282
86MP0003806_abnormal_nucleotide_metabolis0.95220612
87MP0002095_abnormal_skin_pigmentation0.92875404
88MP0005164_abnormal_response_to0.91376294
89MP0010352_gastrointestinal_tract_polyps0.88679232
90MP0000313_abnormal_cell_death0.84519191
91MP0005390_skeleton_phenotype0.84200054
92MP0009763_increased_sensitivity_to0.82782179
93MP0004957_abnormal_blastocyst_morpholog0.80040181
94MP0003091_abnormal_cell_migration0.79528702
95MP0006054_spinal_hemorrhage0.78210799
96MP0003453_abnormal_keratinocyte_physiol0.76469817
97MP0003111_abnormal_nucleus_morphology0.73306115
98MP0003221_abnormal_cardiomyocyte_apopto0.72306489
99MP0008058_abnormal_DNA_repair0.71178964
100MP0003448_altered_tumor_morphology0.70833573
101MP0002009_preneoplasia0.70138480
102MP0000249_abnormal_blood_vessel0.69351736
103MP0002332_abnormal_exercise_endurance0.69235342
104MP0009765_abnormal_xenobiotic_induced0.69053869
105MP0000343_altered_response_to0.68931512
106MP0000678_abnormal_parathyroid_gland0.68550354
107MP0000015_abnormal_ear_pigmentation0.68046329
108MP0001346_abnormal_lacrimal_gland0.67736356
109MP0002909_abnormal_adrenal_gland0.64320307
110MP0003045_fibrosis0.63041807
111MP0000350_abnormal_cell_proliferation0.60914361
112MP0005076_abnormal_cell_differentiation0.60850312
113MP0005645_abnormal_hypothalamus_physiol0.60369034
114MP0005167_abnormal_blood-brain_barrier0.59748511
115MP0000681_abnormal_thyroid_gland0.59258552
116MP0002277_abnormal_respiratory_mucosa0.59013498
117MP0008874_decreased_physiological_sensi0.58699663
118MP0005621_abnormal_cell_physiology0.58112098
119MP0001663_abnormal_digestive_system0.56947230
120MP0003075_altered_response_to0.56684325
121MP0001944_abnormal_pancreas_morphology0.54522555
122MP0003279_aneurysm0.53877550
123MP0004147_increased_porphyrin_level0.51028497
124MP0000609_abnormal_liver_physiology0.47356813
125MP0000569_abnormal_digit_pigmentation0.47309537
126MP0003795_abnormal_bone_structure0.47137861
127MP0005319_abnormal_enzyme/_coenzyme0.46817729
128MP0005384_cellular_phenotype0.46681525
129MP0000371_diluted_coat_color0.46633345
130MP0009764_decreased_sensitivity_to0.46431809
131MP0003191_abnormal_cellular_cholesterol0.46211904

Predicted human phenotypes

RankGene SetZ-score
1Abnormal delayed hypersensitivity skin test (HP:0002963)5.62837509
2Chronic otitis media (HP:0000389)5.36472211
3Recurrent abscess formation (HP:0002722)4.79015632
4Eczematoid dermatitis (HP:0000976)4.54010212
5Recurrent bacterial skin infections (HP:0005406)4.46989222
6Thrombocytosis (HP:0001894)4.28764819
7Recurrent fungal infections (HP:0002841)4.19823693
8Panhypogammaglobulinemia (HP:0003139)4.09618326
9Recurrent cutaneous fungal infections (HP:0011370)4.06685082
10Chronic mucocutaneous candidiasis (HP:0002728)4.06685082
11Elevated erythrocyte sedimentation rate (HP:0003565)3.96623377
12IgM deficiency (HP:0002850)3.90893217
13Abnormality of T cell physiology (HP:0011840)3.84689824
14Recurrent viral infections (HP:0004429)3.84383337
15Agammaglobulinemia (HP:0004432)3.61958639
16Myositis (HP:0100614)3.59799739
17Recurrent skin infections (HP:0001581)3.59164216
18Gastrointestinal infarctions (HP:0005244)3.55870682
19Gastrointestinal inflammation (HP:0004386)3.49046544
20Cellulitis (HP:0100658)3.48094067
21Abnormal number of erythroid precursors (HP:0012131)3.45194258
22Abnormality of cells of the erythroid lineage (HP:0012130)3.44034558
23Abnormality of glycolipid metabolism (HP:0010969)3.38906422
24Abnormality of liposaccharide metabolism (HP:0010968)3.38906422
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.38906422
26Recurrent bronchitis (HP:0002837)3.38038488
27Inflammation of the large intestine (HP:0002037)3.36069475
28Abnormality of T cells (HP:0002843)3.31599052
29Meningitis (HP:0001287)3.26657815
30Increased cerebral lipofuscin (HP:0011813)3.21733058
31Nasal polyposis (HP:0100582)3.19644875
32Petechiae (HP:0000967)3.18248393
33Autoimmune thrombocytopenia (HP:0001973)3.15149417
34Mediastinal lymphadenopathy (HP:0100721)3.06150628
35Chronic obstructive pulmonary disease (HP:0006510)3.06021375
36Obstructive lung disease (HP:0006536)3.06021375
37Keratoconjunctivitis sicca (HP:0001097)3.00246911
38Amyloidosis (HP:0011034)2.99595017
39Colitis (HP:0002583)2.94861121
40Increased IgM level (HP:0003496)2.86994644
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.85161490
42Abnormality of macrophages (HP:0004311)2.83332980
43Hemoptysis (HP:0002105)2.82213294
44Abnormality of T cell number (HP:0011839)2.82140782
45Pulmonary infiltrates (HP:0002113)2.81917652
46Prolonged bleeding time (HP:0003010)2.80785953
47Abnormality of the nasal mucosa (HP:0000433)2.79703219
48Abnormality of cells of the lymphoid lineage (HP:0012140)2.72387152
49Increased neuronal autofluorescent lipopigment (HP:0002074)2.68681680
50Loss of speech (HP:0002371)2.64035018
51Epistaxis (HP:0000421)2.61454582
52Encephalitis (HP:0002383)2.57333712
53Reticulocytopenia (HP:0001896)2.55916606
54Lymphopenia (HP:0001888)2.50667324
55Vasculitis (HP:0002633)2.49607673
56Increased IgE level (HP:0003212)2.48355814
57Chronic sinusitis (HP:0011109)2.48164633
58Increased serum ferritin (HP:0003281)2.45433355
59Episodic fever (HP:0001954)2.45092775
60Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44733649
61Hypergammaglobulinemia (HP:0010702)2.42508981
62Papilloma (HP:0012740)2.42302473
63Verrucae (HP:0200043)2.42302473
64Urticaria (HP:0001025)2.37936617
65Broad face (HP:0000283)2.36969354
66IgG deficiency (HP:0004315)2.36941270
67Hypochromic anemia (HP:0001931)2.34968916
68Eosinophilia (HP:0001880)2.32040315
69Interstitial pulmonary disease (HP:0006530)2.29557230
70Stomatitis (HP:0010280)2.28616969
71T lymphocytopenia (HP:0005403)2.28259968
72Aplastic anemia (HP:0001915)2.25197080
73Vacuolated lymphocytes (HP:0001922)2.25106862
74Pulmonary embolism (HP:0002204)2.23368172
75Hepatosplenomegaly (HP:0001433)2.21896375
76Pallor (HP:0000980)2.21323093
77Periodontitis (HP:0000704)2.20472808
78Anorexia (HP:0002039)2.20179943
79Pustule (HP:0200039)2.19703075
80Recurrent gram-negative bacterial infections (HP:0005420)2.18453348
81Leukocytosis (HP:0001974)2.17890528
82Granulocytopenia (HP:0001913)2.17342934
83Amaurosis fugax (HP:0100576)2.16880474
84Spontaneous hematomas (HP:0007420)2.16103903
85Autoimmune hemolytic anemia (HP:0001890)2.16026363
86Viral hepatitis (HP:0006562)2.15309944
87Sepsis (HP:0100806)2.14282384
88Slow saccadic eye movements (HP:0000514)2.12814521
89Abnormal platelet function (HP:0011869)2.12783843
90Impaired platelet aggregation (HP:0003540)2.12783843
91Abnormality of eosinophils (HP:0001879)2.09623919
92Lymphoma (HP:0002665)2.08868926
93Abnormality of the pleura (HP:0002103)2.08618954
94Abnormality of iron homeostasis (HP:0011031)2.08229852
95Gangrene (HP:0100758)2.07709005
96Neutropenia (HP:0001875)2.07492328
97Restrictive lung disease (HP:0002091)2.06260708
98Abnormality of the peritoneum (HP:0002585)2.05628305
99Fatigue (HP:0012378)2.05152162
100Chest pain (HP:0100749)2.04648103
101Systemic lupus erythematosus (HP:0002725)2.03291852
102Orchitis (HP:0100796)2.01663391
103Optic neuritis (HP:0100653)2.00092612
104Retrobulbar optic neuritis (HP:0100654)2.00092612
105Skin ulcer (HP:0200042)1.99770759
106Purpura (HP:0000979)1.99138174
107Glomerulopathy (HP:0100820)1.99114054
108Disinhibition (HP:0000734)1.98744915
109Progressive muscle weakness (HP:0003323)1.96616889
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96322010
111Premature loss of primary teeth (HP:0006323)1.95713786
112Basal cell carcinoma (HP:0002671)1.95505122
113Gastrointestinal stroma tumor (HP:0100723)1.95043032
114Basal ganglia calcification (HP:0002135)1.94811807
11511 pairs of ribs (HP:0000878)1.94111283
116Abnormality of polysaccharide metabolism (HP:0011012)1.93698330
117Abnormality of glycosaminoglycan metabolism (HP:0004371)1.93698330
118Abnormality of mucopolysaccharide metabolism (HP:0011020)1.93698330
119Abnormality of the endocardium (HP:0004306)1.93105681
120Osteomyelitis (HP:0002754)1.91359531
121Polyneuropathy (HP:0001271)1.90942087
122Poikilocytosis (HP:0004447)1.89907683
123Abnormal protein glycosylation (HP:0012346)1.89516357
124Abnormal glycosylation (HP:0012345)1.89516357
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89516357
126Abnormal protein N-linked glycosylation (HP:0012347)1.89516357
127Dysostosis multiplex (HP:0000943)1.88956663
128Myocardial infarction (HP:0001658)1.88632268
129Acanthocytosis (HP:0001927)1.86682875
130Emphysema (HP:0002097)1.85669530
131Macrocytic anemia (HP:0001972)1.84906259
132Papilledema (HP:0001085)1.83257126
133Arterial thrombosis (HP:0004420)1.82566185
134Hypercortisolism (HP:0001578)1.80826988
135Bronchitis (HP:0012387)1.80712162
136Gingivitis (HP:0000230)1.80534125
137Keratoconjunctivitis (HP:0001096)1.80406910
138Gingival bleeding (HP:0000225)1.79711966

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.06630286
2PRPF4B3.15785110
3JAK32.74329927
4FLT32.70248419
5KIT2.56294308
6IRAK42.54104255
7TYK22.40186419
8BTK2.32584225
9NME22.27536069
10EEF2K2.22269484
11MAP3K142.20736066
12TEC2.11898885
13PIM22.07926298
14TBK12.07503922
15MAP3K132.06654176
16ZAP701.93192655
17SCYL21.84982811
18MAP3K31.83833598
19IKBKB1.83255689
20CSF1R1.83089986
21FES1.79888350
22IKBKE1.73226850
23STK101.68393295
24SYK1.68227864
25CLK11.66899346
26FGR1.63855590
27BLK1.57888169
28MAP2K31.57066538
29LRRK21.56021774
30EPHB11.50561700
31PASK1.46388277
32EIF2AK11.46131002
33BMPR21.43503732
34TXK1.40387244
35TRIB31.39717181
36ITK1.38905657
37TAOK21.38094395
38GRK61.35405732
39PKN21.31709116
40ACVR1B1.28603154
41IRAK21.27083135
42HIPK21.26745670
43TESK21.23031201
44PIM11.22729231
45CDK121.21715047
46IRAK31.21181758
47LCK1.17736333
48TGFBR11.12680676
49TLK11.12329311
50IRAK11.06995805
51STK161.05748964
52CHUK1.04028769
53JAK11.03350315
54KSR21.02534678
55LYN0.98701906
56NLK0.98275560
57RIPK40.97549330
58HCK0.97290689
59MARK20.96587051
60MAP3K100.95772832
61SMG10.95754142
62CDK190.95569486
63SIK20.92691977
64CSK0.92690142
65ARAF0.90913353
66MAPK120.90406180
67MAP3K110.89799496
68RPS6KA40.88840221
69JAK20.86418479
70CDC42BPA0.82252474
71ERN10.81386724
72RPS6KB20.80158129
73PDK10.80063963
74TNIK0.76493857
75MAPK70.75931168
76PDPK10.75392921
77KDR0.74593382
78RAF10.74170320
79SIK10.73785844
80CDC70.71849597
81BUB10.70185552
82NEK20.69096626
83ALK0.69004676
84VRK10.68163972
85DYRK30.67953436
86PRKD20.67921811
87TAOK30.67882451
88MAP3K120.67384129
89PAK40.66504469
90MAP3K60.65576136
91MAP3K80.63560343
92TNK20.62740925
93YES10.62117374
94MAP3K70.59468395
95EIF2AK30.58533931
96GRK70.57799144
97TTN0.56755894
98MAPKAPK20.56612424
99CDK60.54594233
100FGFR40.54492061
101WEE10.54230952
102TSSK60.50646379
103MAP3K50.49477482
104RPS6KA60.49117338
105TESK10.48085367
106MAP2K20.47312413
107MARK30.46880376
108CAMK1D0.46456894
109PTK60.46156909
110ICK0.45134260
111TGFBR20.44892923
112SGK30.44802145
113RPS6KA50.44291510
114FYN0.42995845
115RPS6KA20.42278097
116MAP3K10.41118132
117RPS6KA10.38023002
118PRKCQ0.38012280
119MAPK150.37649817
120TAOK10.37432818
121STK40.37408718
122BRSK20.35711593
123CDK80.35051206
124FGFR30.35017936
125MAPK110.34853275
126MATK0.34413678
127ADRBK20.34236842
128MAPKAPK30.33559802
129RPS6KC10.33492962
130RPS6KL10.33492962
131PIK3CG0.33409202
132MAPK40.33261601
133CDK40.33206493
134SIK30.31710343
135MOS0.31345962
136CAMKK10.30734492

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.86023873
2Ribosome_Homo sapiens_hsa030102.77519551
3Staphylococcus aureus infection_Homo sapiens_hsa051502.57057933
4DNA replication_Homo sapiens_hsa030302.48642833
5Leishmaniasis_Homo sapiens_hsa051402.24157232
6Antigen processing and presentation_Homo sapiens_hsa046122.22860213
7B cell receptor signaling pathway_Homo sapiens_hsa046622.14920677
8Allograft rejection_Homo sapiens_hsa053302.02216011
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.95745361
10Measles_Homo sapiens_hsa051621.87617239
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.78683004
12Intestinal immune network for IgA production_Homo sapiens_hsa046721.75724263
13Shigellosis_Homo sapiens_hsa051311.73689691
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71822660
15Osteoclast differentiation_Homo sapiens_hsa043801.68778007
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68680283
17Acute myeloid leukemia_Homo sapiens_hsa052211.64404661
18Type I diabetes mellitus_Homo sapiens_hsa049401.56111329
19Herpes simplex infection_Homo sapiens_hsa051681.53888716
20Protein export_Homo sapiens_hsa030601.49040025
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48150201
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.47463048
23Mismatch repair_Homo sapiens_hsa034301.47155675
24Rheumatoid arthritis_Homo sapiens_hsa053231.46742826
25Base excision repair_Homo sapiens_hsa034101.45804031
26Hematopoietic cell lineage_Homo sapiens_hsa046401.43429429
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.40075490
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38386574
29T cell receptor signaling pathway_Homo sapiens_hsa046601.37800483
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37188088
31Apoptosis_Homo sapiens_hsa042101.36360169
32Toxoplasmosis_Homo sapiens_hsa051451.36014095
33Chemokine signaling pathway_Homo sapiens_hsa040621.35258854
34Graft-versus-host disease_Homo sapiens_hsa053321.34404772
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32358196
36Phagosome_Homo sapiens_hsa041451.31060460
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26527202
38Chronic myeloid leukemia_Homo sapiens_hsa052201.25192738
39p53 signaling pathway_Homo sapiens_hsa041151.23475250
40Homologous recombination_Homo sapiens_hsa034401.19930314
41Legionellosis_Homo sapiens_hsa051341.18943891
42Spliceosome_Homo sapiens_hsa030401.18761167
43Hepatitis B_Homo sapiens_hsa051611.16377406
44Epstein-Barr virus infection_Homo sapiens_hsa051691.16261722
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16046973
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15466448
47Non-homologous end-joining_Homo sapiens_hsa034501.14842685
48Autoimmune thyroid disease_Homo sapiens_hsa053201.13799341
49Proteasome_Homo sapiens_hsa030501.09483091
50Tuberculosis_Homo sapiens_hsa051521.08370863
51Viral carcinogenesis_Homo sapiens_hsa052031.05852650
52Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04201228
53TNF signaling pathway_Homo sapiens_hsa046681.03880019
54African trypanosomiasis_Homo sapiens_hsa051431.03282358
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.02257885
56Influenza A_Homo sapiens_hsa051641.01390667
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.00245078
58Platelet activation_Homo sapiens_hsa046110.99925674
59Viral myocarditis_Homo sapiens_hsa054160.98446641
60Prolactin signaling pathway_Homo sapiens_hsa049170.97581013
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.96836317
62Other glycan degradation_Homo sapiens_hsa005110.94296930
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.93869562
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93041288
65Pancreatic cancer_Homo sapiens_hsa052120.90672917
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89588633
67Nucleotide excision repair_Homo sapiens_hsa034200.88031106
68Asthma_Homo sapiens_hsa053100.88002636
69RNA polymerase_Homo sapiens_hsa030200.87988169
70Malaria_Homo sapiens_hsa051440.87682566
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86102153
72Cell cycle_Homo sapiens_hsa041100.86082146
73Pyrimidine metabolism_Homo sapiens_hsa002400.85725221
74HTLV-I infection_Homo sapiens_hsa051660.82815487
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80183996
76Pertussis_Homo sapiens_hsa051330.78939926
77Renal cell carcinoma_Homo sapiens_hsa052110.77350511
78Non-small cell lung cancer_Homo sapiens_hsa052230.77313760
79One carbon pool by folate_Homo sapiens_hsa006700.74912925
80N-Glycan biosynthesis_Homo sapiens_hsa005100.74047623
81* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.72531449
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72214018
83Salmonella infection_Homo sapiens_hsa051320.71291555
84Bladder cancer_Homo sapiens_hsa052190.67996379
85VEGF signaling pathway_Homo sapiens_hsa043700.66112820
86Notch signaling pathway_Homo sapiens_hsa043300.65533377
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64777846
88GnRH signaling pathway_Homo sapiens_hsa049120.64442012
89Small cell lung cancer_Homo sapiens_hsa052220.64010163
90Systemic lupus erythematosus_Homo sapiens_hsa053220.62302068
91Amoebiasis_Homo sapiens_hsa051460.61278717
92Thyroid cancer_Homo sapiens_hsa052160.61017433
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.60873915
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59816899
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59638570
96Sulfur relay system_Homo sapiens_hsa041220.59583746
97RNA degradation_Homo sapiens_hsa030180.58918854
98HIF-1 signaling pathway_Homo sapiens_hsa040660.58886067
99FoxO signaling pathway_Homo sapiens_hsa040680.58474022
100mTOR signaling pathway_Homo sapiens_hsa041500.57741755
101Hepatitis C_Homo sapiens_hsa051600.56781429
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56330855
103RNA transport_Homo sapiens_hsa030130.54940092
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53514956
105Endometrial cancer_Homo sapiens_hsa052130.52934031
106Choline metabolism in cancer_Homo sapiens_hsa052310.52451832
107Lysosome_Homo sapiens_hsa041420.52337441
108Colorectal cancer_Homo sapiens_hsa052100.51577209
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50806314
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.49734993
111Pentose phosphate pathway_Homo sapiens_hsa000300.48488239
112Inositol phosphate metabolism_Homo sapiens_hsa005620.47427340
113Dorso-ventral axis formation_Homo sapiens_hsa043200.46353930
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45999760
115Insulin resistance_Homo sapiens_hsa049310.44942390
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.43691834
117Alcoholism_Homo sapiens_hsa050340.42053724
118ErbB signaling pathway_Homo sapiens_hsa040120.41947713
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40827794
120MAPK signaling pathway_Homo sapiens_hsa040100.40228389
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40210824
122Prostate cancer_Homo sapiens_hsa052150.39703590
123Endocytosis_Homo sapiens_hsa041440.39619715
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.38857109
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35833367
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34717566
127Estrogen signaling pathway_Homo sapiens_hsa049150.34640100
128Type II diabetes mellitus_Homo sapiens_hsa049300.33809428
129Glioma_Homo sapiens_hsa052140.32163442
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30021502
131Insulin signaling pathway_Homo sapiens_hsa049100.29238756

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