REM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1metanephric mesenchyme development (GO:0072075)8.88509592
2kidney mesenchyme development (GO:0072074)8.60444796
3mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)8.22890425
4negative regulation of metanephros development (GO:0072217)7.82394780
5mesenchymal to epithelial transition (GO:0060231)7.31619584
6mesonephros development (GO:0001823)6.18314976
7mesenchymal cell differentiation involved in renal system development (GO:2001012)5.85875908
8mesenchymal cell differentiation involved in kidney development (GO:0072161)5.85875908
9glomerulus development (GO:0032835)5.83970659
10regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033395.83880878
11diaphragm development (GO:0060539)5.57962968
12metanephros development (GO:0001656)5.49540591
13positive regulation of metanephros development (GO:0072216)5.31778087
14glomerular basement membrane development (GO:0032836)5.30084216
15metanephric epithelium development (GO:0072207)5.29080565
16skeletal muscle organ development (GO:0060538)5.28197133
17outer ear morphogenesis (GO:0042473)5.21132625
18negative regulation of kidney development (GO:0090185)5.09056789
19organ induction (GO:0001759)4.97492205
20cell proliferation involved in metanephros development (GO:0072203)4.85020328
21sarcoplasmic reticulum calcium ion transport (GO:0070296)4.77093523
22negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.70031884
23embryonic skeletal joint morphogenesis (GO:0060272)4.69040966
24regulation of metanephros development (GO:0072215)4.68581973
25adhesion of symbiont to host cell (GO:0044650)4.67153832
26virion attachment to host cell (GO:0019062)4.67153832
27lymph vessel development (GO:0001945)4.67049962
28muscle cell fate commitment (GO:0042693)4.63948544
29branching involved in ureteric bud morphogenesis (GO:0001658)4.52348952
30regulation of organ formation (GO:0003156)4.46974691
31regulation of glomerulus development (GO:0090192)4.38614122
32cardiac myofibril assembly (GO:0055003)4.24923850
33proximal/distal pattern formation (GO:0009954)4.16844873
34pattern specification involved in kidney development (GO:0061004)4.06254176
35regulation of mesonephros development (GO:0061217)4.05749313
36regulation of membrane protein ectodomain proteolysis (GO:0051043)3.97388983
37adhesion of symbiont to host (GO:0044406)3.97300409
38negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.94316341
39positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.93965682
40positive regulation of mesonephros development (GO:0061213)3.90409704
41regulation of apoptotic process involved in morphogenesis (GO:1902337)3.86377184
42cell proliferation involved in kidney development (GO:0072111)3.83658528
43regulation of vitamin D biosynthetic process (GO:0060556)3.83268367
44cell differentiation involved in metanephros development (GO:0072202)3.80469974
45sarcomere organization (GO:0045214)3.80416203
46positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.72963616
47regulation of mononuclear cell migration (GO:0071675)3.70915216
48basement membrane organization (GO:0071711)3.69489916
49positive regulation of male gonad development (GO:2000020)3.68422885
50barbed-end actin filament capping (GO:0051016)3.67916287
51nephron tubule morphogenesis (GO:0072078)3.66279468
52nephron epithelium morphogenesis (GO:0072088)3.66279468
53mesonephric tubule development (GO:0072164)3.63798884
54keratan sulfate catabolic process (GO:0042340)3.63071962
55mesonephric epithelium development (GO:0072163)3.62250207
56cell differentiation involved in kidney development (GO:0061005)3.53858100
57myofibril assembly (GO:0030239)3.52869096
58cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.52473371
59regulation of mesenchymal cell apoptotic process (GO:2001053)3.49421748
60actin-myosin filament sliding (GO:0033275)3.44916255
61muscle filament sliding (GO:0030049)3.44916255
62metanephric tubule development (GO:0072170)3.44631106
63metanephric nephron tubule development (GO:0072234)3.44631106
64epithelial cell morphogenesis (GO:0003382)3.44212027
65regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.40571619
66ureteric bud development (GO:0001657)3.40418450
67negative regulation of nitric oxide biosynthetic process (GO:0045019)3.39457112
68regulation of cell proliferation involved in kidney development (GO:1901722)3.36425261
69cellular response to thyroid hormone stimulus (GO:0097067)3.35305276
70plasma membrane repair (GO:0001778)3.33752087
71regulation of vitamin metabolic process (GO:0030656)3.29789125
72nephron tubule development (GO:0072080)3.29428855
73mesenchyme morphogenesis (GO:0072132)3.27984230
74positive regulation of cellular amide metabolic process (GO:0034250)3.25718167
75epithelial cell differentiation involved in kidney development (GO:0035850)3.24334332
76paraxial mesoderm development (GO:0048339)3.23104209
77regulation of cholesterol storage (GO:0010885)3.22559790
78regulation of male gonad development (GO:2000018)3.21951976
79regulation of kidney development (GO:0090183)3.19863318
80metanephric nephron epithelium development (GO:0072243)3.19228205
81adrenal gland development (GO:0030325)3.18474409
82heart contraction (GO:0060047)3.18135821
83heart process (GO:0003015)3.18135821
84chondrocyte proliferation (GO:0035988)3.17028760
85developmental induction (GO:0031128)3.16336059
86collagen fibril organization (GO:0030199)3.16284120
87vascular endothelial growth factor signaling pathway (GO:0038084)3.14848861
88renal tubule morphogenesis (GO:0061333)3.12532603
89regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.12130749
90atrioventricular valve morphogenesis (GO:0003181)3.10831282
91skeletal muscle adaptation (GO:0043501)3.08486426
92positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.08191476
93mesenchymal cell differentiation (GO:0048762)3.06415927
94germinal center formation (GO:0002467)3.06188473
95cell-cell signaling involved in cell fate commitment (GO:0045168)3.06023102
96glial cell migration (GO:0008347)3.05638441
97actin-mediated cell contraction (GO:0070252)3.04635312
98heart trabecula formation (GO:0060347)3.04044375
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.02790576
100kidney epithelium development (GO:0072073)3.02410416
101actomyosin structure organization (GO:0031032)3.01098241
102striated muscle atrophy (GO:0014891)2.99447879
103nephron epithelium development (GO:0072009)2.98735376
104myeloid dendritic cell differentiation (GO:0043011)2.97922929
105mesenchyme development (GO:0060485)2.96182544
106negative regulation of interleukin-12 production (GO:0032695)2.95315722
107regulation of podosome assembly (GO:0071801)2.94228491
108negative regulation of smooth muscle cell proliferation (GO:0048662)2.93079214
109NIK/NF-kappaB signaling (GO:0038061)2.93027297
110positive regulation of heat generation (GO:0031652)2.92589221
111middle ear morphogenesis (GO:0042474)2.92189563
112cellular response to cadmium ion (GO:0071276)2.91228354
113positive regulation of kidney development (GO:0090184)2.91138783
114cardiac cell development (GO:0055006)2.90949657
115negative regulation of adherens junction organization (GO:1903392)2.90908677
116negative regulation of focal adhesion assembly (GO:0051895)2.90908677
117negative regulation of cell junction assembly (GO:1901889)2.90908677
118regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.90670028
119cardiac muscle cell development (GO:0055013)2.89805636
120low-density lipoprotein particle clearance (GO:0034383)2.89067581
121maternal placenta development (GO:0001893)2.88985525
122negative regulation of erythrocyte differentiation (GO:0045647)2.87692374
123mesenchymal cell proliferation (GO:0010463)2.87066019
124positive regulation of cartilage development (GO:0061036)2.85839457
125retina vasculature morphogenesis in camera-type eye (GO:0061299)2.84671097
126potassium ion export (GO:0071435)2.84395814
127positive regulation of chondrocyte differentiation (GO:0032332)2.83682410
128renal tubule development (GO:0061326)2.82999603
129negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.81080125
130positive regulation of chemokine secretion (GO:0090197)2.80874238
131transcytosis (GO:0045056)2.79854323
132regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.79611350
133protein heterotrimerization (GO:0070208)2.77808093
134hydrogen peroxide biosynthetic process (GO:0050665)2.77104184
135lymphangiogenesis (GO:0001946)2.76779229
136regulation of macrophage chemotaxis (GO:0010758)2.76305993
137regulation of T-helper 1 cell differentiation (GO:0045625)2.76161816
138regulation of female gonad development (GO:2000194)2.76056078
139kidney development (GO:0001822)2.75252424
140urogenital system development (GO:0001655)2.72941240
141embryonic digestive tract development (GO:0048566)2.70822128
142skeletal muscle contraction (GO:0003009)2.70550396
143cardiac muscle contraction (GO:0060048)2.67806418
144activation of MAPKKK activity (GO:0000185)2.67221703
145positive regulation of chemokine biosynthetic process (GO:0045080)2.66889582
146regulation of cytokine secretion involved in immune response (GO:0002739)2.65696829
147regulation of skeletal muscle contraction (GO:0014819)2.65579513
148regulation of fever generation (GO:0031620)2.62523260
149lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60590487
150regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.58316748
151fat-soluble vitamin biosynthetic process (GO:0042362)2.57280874
152glycosphingolipid catabolic process (GO:0046479)2.56932521
153cellular response to zinc ion (GO:0071294)2.56370981
154branching involved in labyrinthine layer morphogenesis (GO:0060670)2.56275727
155negative regulation of protein localization to cell surface (GO:2000009)2.52868578
156negative regulation of platelet activation (GO:0010544)2.51759705
157regulation of chemokine biosynthetic process (GO:0045073)2.51495333
158regulation of cytokine production involved in inflammatory response (GO:1900015)2.50330130
159regulation of nitric oxide biosynthetic process (GO:0045428)2.50129839
160striated muscle contraction (GO:0006941)2.46974532
161cellular response to epinephrine stimulus (GO:0071872)2.46654923
162T-helper 1 type immune response (GO:0042088)2.45958863
163axonemal dynein complex assembly (GO:0070286)2.45878838
164muscle atrophy (GO:0014889)2.45506449
165positive regulation of lipid storage (GO:0010884)2.45202551
166cell volume homeostasis (GO:0006884)2.44757790
167creatine metabolic process (GO:0006600)2.44680578
168positive regulation of cholesterol efflux (GO:0010875)2.44030445
169positive regulation of triglyceride lipase activity (GO:0061365)2.43278904
170positive regulation of lipoprotein lipase activity (GO:0051006)2.43278904
171apoptotic cell clearance (GO:0043277)2.42036020
172immunoglobulin mediated immune response (GO:0016064)2.41743621
173embryo implantation (GO:0007566)2.41565812
174fibril organization (GO:0097435)2.41160606
175response to thyroid hormone (GO:0097066)2.38660119
176actin filament-based movement (GO:0030048)2.38386521
177pinocytosis (GO:0006907)2.37204606
178mannose metabolic process (GO:0006013)2.35095511
179negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.34406220
180reactive oxygen species biosynthetic process (GO:1903409)2.33588793
181response to peptidoglycan (GO:0032494)2.32974066
182eosinophil chemotaxis (GO:0048245)2.32277331
183decidualization (GO:0046697)2.31438942
184positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.30367264
185stress fiber assembly (GO:0043149)2.30337898
186regulation of response to osmotic stress (GO:0047484)2.29549940
187muscle adaptation (GO:0043500)2.29296711
188negative regulation of lipid storage (GO:0010888)2.28767284
189glycolipid catabolic process (GO:0019377)2.28246197
190regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.27124797
191monocyte chemotaxis (GO:0002548)2.27056180
192type I interferon signaling pathway (GO:0060337)2.26906282
193cellular response to type I interferon (GO:0071357)2.26906282
194interferon-gamma-mediated signaling pathway (GO:0060333)2.26296325
195positive regulation of antigen processing and presentation (GO:0002579)2.25686986
196response to type I interferon (GO:0034340)2.25597717
197cAMP biosynthetic process (GO:0006171)2.24955884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90910140
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.56585494
3CLOCK_20551151_ChIP-Seq_293T_Human4.46125306
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.22728474
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.97542857
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.12732337
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.07840869
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.90868419
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.90582956
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.90320711
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.76449307
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.70394220
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65986176
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61853616
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.54185322
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.52898281
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.51069844
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.50007132
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.49245481
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.45062679
21WT1_19549856_ChIP-ChIP_CCG9911_Human2.43447058
22* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.39769100
23LXR_22292898_ChIP-Seq_THP-1_Human2.36712824
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35823968
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.21290160
26TBX20_22328084_ChIP-Seq_HEART_Mouse2.12710522
27TBX20_22080862_ChIP-Seq_HEART_Mouse2.12710522
28ELK3_25401928_ChIP-Seq_HUVEC_Human2.08325925
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08312180
30ESR2_21235772_ChIP-Seq_MCF-7_Human2.06369623
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.03311332
32MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.98037217
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.96290553
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94509211
35SALL4_18804426_ChIP-ChIP_XEN_Mouse1.91447509
36NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.83354176
37CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.79409603
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.78470397
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77971670
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76335483
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71802649
42* EED_16625203_ChIP-ChIP_MESCs_Mouse1.71621614
43IRF8_27001747_Chip-Seq_BMDM_Mouse1.70698946
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.69156437
45CJUN_26792858_Chip-Seq_BT549_Human1.64484608
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.64370845
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61867038
48* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60489306
49BRD4_25478319_ChIP-Seq_HGPS_Human1.58494559
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57451128
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57085758
52GATA1_22025678_ChIP-Seq_K562_Human1.56701257
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.55781506
54RACK7_27058665_Chip-Seq_MCF-7_Human1.53850906
55GATA4_21415370_ChIP-Seq_HL-1_Mouse1.51188331
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.45248996
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45211186
58UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43748149
59TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40210472
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39740292
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.38955339
62VDR_21846776_ChIP-Seq_THP-1_Human1.38072475
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.37601814
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36580689
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35406352
66* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.35069901
67* SMC4_20622854_ChIP-Seq_HELA_Human1.34754743
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34264196
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33679559
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32176074
71TP53_22127205_ChIP-Seq_IMR90_Human1.31611291
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.31578363
73PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31337832
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30740163
75UBF1/2_26484160_Chip-Seq_HMECs_Human1.30255608
76STAT1_20625510_ChIP-Seq_HELA_Human1.29279469
77STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28959441
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28722977
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27503614
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27503614
81DROSHA_22980978_ChIP-Seq_HELA_Human1.25255253
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.24915680
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.24568422
84CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24344550
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24060536
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23892481
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23892481
88SA1_27219007_Chip-Seq_Bcells_Human1.21701798
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20782930
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20782811
91* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20371423
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20053082
93RAD21_21589869_ChIP-Seq_MESCs_Mouse1.19429955
94BCOR_27268052_Chip-Seq_Bcells_Human1.18410802
95SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17939056
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17720834
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17257259
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16511169
99CDX2_20551321_ChIP-Seq_CACO-2_Human1.16174660
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15620582
101EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15312322
102RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15307122
103BCL6_27268052_Chip-Seq_Bcells_Human1.14999635
104VDR_24763502_ChIP-Seq_THP-1_Human1.14596980
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14576647
106* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14423195
107SPI1_23127762_ChIP-Seq_K562_Human1.13923107
108* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.13304664
109ZNF263_19887448_ChIP-Seq_K562_Human1.12937660
110CTCF_27219007_Chip-Seq_Bcells_Human1.12931050
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.12434712
112P68_20966046_ChIP-Seq_HELA_Human1.12204300
113KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11470671
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11237482
115STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11069925
116KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10815489
117ATF3_27146783_Chip-Seq_COLON_Human1.10797000
118STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09929878
119PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08969093
120LXR_22158963_ChIP-Seq_LIVER_Mouse1.08372092
121SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07860833
122ELF1_20517297_ChIP-Seq_JURKAT_Human1.06372574
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06237556
124GATA2_21666600_ChIP-Seq_HMVEC_Human1.05977751
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05706953
126P63_26484246_Chip-Seq_KERATINOCYTES_Human1.05481815
127NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04099987
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04099987
129EZH2_22144423_ChIP-Seq_EOC_Human1.03883463
130SOX2_20726797_ChIP-Seq_SW620_Human1.03809577
131TP63_22573176_ChIP-Seq_HFKS_Human1.03764379
132AR_21909140_ChIP-Seq_LNCAP_Human1.03604461
133TCF7_22412390_ChIP-Seq_EML_Mouse1.01972668
134JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01830468
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01024518
136RXR_22158963_ChIP-Seq_LIVER_Mouse1.00135504
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99289292
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98823054
139TET1_21451524_ChIP-Seq_MESCs_Mouse0.98577217
140SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98251814
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97183791
142CTCF_26484167_Chip-Seq_Bcells_Mouse0.96617493
143* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95716950
144SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95595319
145STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95273630
146STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95259259
147VDR_24787735_ChIP-Seq_THP-1_Human0.94578933
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94350633
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93650133
150EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93060031
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92291437
152KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92069636
153STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.90456668
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.90195868
155BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90107336
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.89579446
157ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89071492
158NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88910152
159SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87568789
160TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.86195130
161KDM2B_26808549_Chip-Seq_K562_Human0.85214827
162KDM2B_26808549_Chip-Seq_DND41_Human0.84328349
163SA1_22415368_ChIP-Seq_MEFs_Mouse0.84087741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.83371761
2MP0005503_abnormal_tendon_morphology3.68521398
3MP0004510_myositis3.64428647
4MP0003942_abnormal_urinary_system3.39270611
5MP0003303_peritoneal_inflammation3.37925410
6MP0003646_muscle_fatigue3.37581574
7MP0002837_dystrophic_cardiac_calcinosis3.30155290
8MP0005058_abnormal_lysosome_morphology3.18992049
9MP0003123_paternal_imprinting3.16858462
10MP0009840_abnormal_foam_cell3.05912114
11MP0000534_abnormal_ureter_morphology3.05383467
12MP0003279_aneurysm2.95358474
13MP0005275_abnormal_skin_tensile2.80561885
14MP0000751_myopathy2.78998978
15MP0004272_abnormal_basement_membrane2.76855836
16MP0004084_abnormal_cardiac_muscle2.72344866
17MP0001879_abnormal_lymphatic_vessel2.68888571
18MP0003705_abnormal_hypodermis_morpholog2.61612810
19MP0005623_abnormal_meninges_morphology2.59240081
20MP0000343_altered_response_to2.40757590
21MP0000749_muscle_degeneration2.35747447
22MP0005451_abnormal_body_composition2.33463528
23MP0010368_abnormal_lymphatic_system2.29966573
24MP0002148_abnormal_hypersensitivity_rea2.28576731
25MP0003724_increased_susceptibility_to2.27889900
26MP0005167_abnormal_blood-brain_barrier2.11965968
27MP0000750_abnormal_muscle_regeneration2.06807170
28MP0003075_altered_response_to2.06491898
29MP0005666_abnormal_adipose_tissue2.02385737
30MP0003436_decreased_susceptibility_to1.98145671
31MP0003385_abnormal_body_wall1.91530240
32MP0000767_abnormal_smooth_muscle1.90952389
33MP0001958_emphysema1.88618951
34MP0010030_abnormal_orbit_morphology1.85534627
35MP0002108_abnormal_muscle_morphology1.85171127
36MP0008004_abnormal_stomach_pH1.85068027
37MP0006082_CNS_inflammation1.84253623
38MP0009785_altered_susceptibility_to1.84220925
39MP0002254_reproductive_system_inflammat1.81982685
40MP0005330_cardiomyopathy1.81196161
41MP0000604_amyloidosis1.79593104
42MP0010630_abnormal_cardiac_muscle1.72960029
43MP0009053_abnormal_anal_canal1.71089590
44MP0004036_abnormal_muscle_relaxation1.69968681
45MP0003828_pulmonary_edema1.69644400
46MP0001533_abnormal_skeleton_physiology1.69519701
47MP0004215_abnormal_myocardial_fiber1.66551005
48MP0009250_abnormal_appendicular_skeleto1.65481335
49MP0006138_congestive_heart_failure1.65319000
50MP0002332_abnormal_exercise_endurance1.63837992
51MP0008775_abnormal_heart_ventricle1.61680726
52MP0006054_spinal_hemorrhage1.61185816
53MP0002249_abnormal_larynx_morphology1.60895969
54MP0003329_amyloid_beta_deposits1.59459117
55MP0002269_muscular_atrophy1.55693935
56MP0003122_maternal_imprinting1.55541127
57MP0004087_abnormal_muscle_fiber1.55216272
58MP0004233_abnormal_muscle_weight1.54536697
59MP0001853_heart_inflammation1.53312220
60MP0003115_abnormal_respiratory_system1.52459883
61MP0002972_abnormal_cardiac_muscle1.51622892
62MP0000759_abnormal_skeletal_muscle1.51222582
63MP0003566_abnormal_cell_adhesion1.47251121
64MP0009764_decreased_sensitivity_to1.47049234
65MP0002933_joint_inflammation1.44816644
66MP0005387_immune_system_phenotype1.44518315
67MP0001790_abnormal_immune_system1.44518315
68MP0001544_abnormal_cardiovascular_syste1.43616083
69MP0005385_cardiovascular_system_phenoty1.43616083
70MP0005508_abnormal_skeleton_morphology1.42992386
71MP0003806_abnormal_nucleotide_metabolis1.41237967
72MP0003453_abnormal_keratinocyte_physiol1.39914004
73MP0002998_abnormal_bone_remodeling1.39807012
74MP0002139_abnormal_hepatobiliary_system1.38053363
75MP0002419_abnormal_innate_immunity1.35894856
76MP0005620_abnormal_muscle_contractility1.35459606
77MP0004858_abnormal_nervous_system1.33374010
78MP0005025_abnormal_response_to1.30512287
79MP0003690_abnormal_glial_cell1.30429390
80MP0005369_muscle_phenotype1.30249939
81MP0005166_decreased_susceptibility_to1.28361709
82MP0000733_abnormal_muscle_development1.26391934
83MP0003191_abnormal_cellular_cholesterol1.21650740
84MP0005000_abnormal_immune_tolerance1.21257796
85MP0009278_abnormal_bone_marrow1.20709361
86MP0004130_abnormal_muscle_cell1.20642195
87MP0003121_genomic_imprinting1.20089470
88MP0002128_abnormal_blood_circulation1.19395400
89MP0005084_abnormal_gallbladder_morpholo1.18875419
90MP0002106_abnormal_muscle_physiology1.16482415
91MP0005595_abnormal_vascular_smooth1.13493421
92MP0005023_abnormal_wound_healing1.13440386
93MP0003878_abnormal_ear_physiology1.13208421
94MP0005377_hearing/vestibular/ear_phenot1.13208421
95MP0005397_hematopoietic_system_phenotyp1.11920764
96MP0001545_abnormal_hematopoietic_system1.11920764
97MP0003300_gastrointestinal_ulcer1.11265933
98MP0000266_abnormal_heart_morphology1.09901006
99MP0010155_abnormal_intestine_physiology1.08587567
100MP0001614_abnormal_blood_vessel1.08336854
101MP0005670_abnormal_white_adipose1.07829489
102MP0009384_cardiac_valve_regurgitation1.05607262
103MP0002295_abnormal_pulmonary_circulatio1.04743747
104MP0003567_abnormal_fetal_cardiomyocyte1.01807478
105MP0000003_abnormal_adipose_tissue1.01479508
106MP0002925_abnormal_cardiovascular_devel1.01307416
107MP0002282_abnormal_trachea_morphology0.99528326
108MP0004185_abnormal_adipocyte_glucose0.99375211
109MP0005390_skeleton_phenotype0.99135664
110MP0003941_abnormal_skin_development0.97674495
111MP0003448_altered_tumor_morphology0.95837768
112MP0004147_increased_porphyrin_level0.95503470
113MP0002135_abnormal_kidney_morphology0.94223803
114MP0000858_altered_metastatic_potential0.93160033
115MP0004947_skin_inflammation0.92143536
116MP0003943_abnormal_hepatobiliary_system0.91677386
117MP0005671_abnormal_response_to0.90678541
118MP0003938_abnormal_ear_development0.90618576
119MP0002932_abnormal_joint_morphology0.90505959
120MP0004484_altered_response_of0.90390149
121MP0003950_abnormal_plasma_membrane0.89984861
122MP0000049_abnormal_middle_ear0.88155879
123MP0008260_abnormal_autophagy0.87430041
124MP0000249_abnormal_blood_vessel0.87148889
125MP0001845_abnormal_inflammatory_respons0.86881785
126MP0008469_abnormal_protein_level0.86790287
127MP0002127_abnormal_cardiovascular_syste0.85880221
128MP0003315_abnormal_perineum_morphology0.84890159
129MP0002452_abnormal_antigen_presenting0.82033207
130MP0002115_abnormal_skeleton_extremities0.81775586
131MP0000678_abnormal_parathyroid_gland0.81469955
132MP0003634_abnormal_glial_cell0.80591473
133MP0000163_abnormal_cartilage_morphology0.80349786
134MP0000920_abnormal_myelination0.79717044
135MP0001175_abnormal_lung_morphology0.79619254
136MP0000747_muscle_weakness0.78721622
137MP0005164_abnormal_response_to0.78661911
138MP0002723_abnormal_immune_serum0.77931644
139MP0001835_abnormal_antigen_presentation0.77861867
140MP0009115_abnormal_fat_cell0.77565102
141MP0005375_adipose_tissue_phenotype0.77508952
142MP0002971_abnormal_brown_adipose0.76150320
143MP0002060_abnormal_skin_morphology0.75134767
144MP0000013_abnormal_adipose_tissue0.73576341
145MP0003137_abnormal_impulse_conducting0.72657760
146MP0001542_abnormal_bone_strength0.72332249
147MP0001915_intracranial_hemorrhage0.72263993
148MP0001243_abnormal_dermal_layer0.71675711
149MP0005367_renal/urinary_system_phenotyp0.70793795
150MP0000516_abnormal_urinary_system0.70793795
151MP0003091_abnormal_cell_migration0.70518693
152MP0003935_abnormal_craniofacial_develop0.68593932
153MP0002109_abnormal_limb_morphology0.68485871
154MP0004145_abnormal_muscle_electrophysio0.68400644
155MP0004085_abnormal_heartbeat0.65646252
156MP0005165_increased_susceptibility_to0.64901465
157MP0002138_abnormal_hepatobiliary_system0.64885569
158MP0002938_white_spotting0.64396793
159MP0002114_abnormal_axial_skeleton0.63427723
160MP0002896_abnormal_bone_mineralization0.63423348
161MP0002089_abnormal_postnatal_growth/wei0.63086005

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.26719815
2Systemic lupus erythematosus (HP:0002725)5.03008931
3Mesangial abnormality (HP:0001966)4.77389634
4Abnormality of liposaccharide metabolism (HP:0010968)4.66904091
5Abnormality of glycosphingolipid metabolism (HP:0004343)4.66904091
6Abnormality of glycolipid metabolism (HP:0010969)4.66904091
7Hypoplastic left heart (HP:0004383)4.66686256
8Hypoplastic heart (HP:0001961)4.42788035
9Premature rupture of membranes (HP:0001788)4.36853697
10Broad metatarsal (HP:0001783)4.10350066
11Exercise-induced myalgia (HP:0003738)3.86096976
12Complement deficiency (HP:0004431)3.65234340
13Nuclear cataract (HP:0100018)3.64826631
14Distal lower limb muscle weakness (HP:0009053)3.49396021
15Pancreatic islet-cell hyperplasia (HP:0004510)3.43145147
16Glomerulonephritis (HP:0000099)3.36979617
17Increased connective tissue (HP:0009025)3.33030779
18Type 1 muscle fiber predominance (HP:0003803)3.30167405
19Dysostosis multiplex (HP:0000943)3.25721595
20Right ventricular cardiomyopathy (HP:0011663)3.24883980
21Muscle fiber splitting (HP:0003555)3.23912577
22Soft skin (HP:0000977)3.22442600
23Aortic aneurysm (HP:0004942)3.21564227
24Abnormality of the nasal mucosa (HP:0000433)3.16277592
25Abnormality of the calf musculature (HP:0001430)3.15213222
26Ulnar deviation of the wrist (HP:0003049)3.13775165
27Axonal loss (HP:0003447)3.12414410
28Lipoatrophy (HP:0100578)3.11570383
29Aortic dissection (HP:0002647)3.10095152
30Ventricular tachycardia (HP:0004756)3.08237450
31Abnormality of complement system (HP:0005339)3.07618147
32Loss of speech (HP:0002371)3.07536668
33Hepatoblastoma (HP:0002884)3.06388604
34Ankle contracture (HP:0006466)3.04548242
35Diastasis recti (HP:0001540)3.03059723
36Neurofibrillary tangles (HP:0002185)2.97986009
37Muscle fiber inclusion bodies (HP:0100299)2.89424031
38Sudden death (HP:0001699)2.88832977
39Focal segmental glomerulosclerosis (HP:0000097)2.88417297
40Round ear (HP:0100830)2.87499694
41Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.83983173
42Increased cerebral lipofuscin (HP:0011813)2.76047948
43Cerebral aneurysm (HP:0004944)2.73173466
44Abnormality of dentin (HP:0010299)2.72031697
45Nemaline bodies (HP:0003798)2.70382075
46Bulbar palsy (HP:0001283)2.69257508
47Potter facies (HP:0002009)2.69196506
48Facial shape deformation (HP:0011334)2.69196506
49Natal tooth (HP:0000695)2.67527203
50Pulmonary artery stenosis (HP:0004415)2.67491277
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62844144
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62844144
53Abnormality of polysaccharide metabolism (HP:0011012)2.62844144
54Shallow orbits (HP:0000586)2.62733388
55Abnormal respiratory epithelium morphology (HP:0012253)2.62676959
56Abnormal respiratory motile cilium morphology (HP:0005938)2.62676959
57Mildly elevated creatine phosphokinase (HP:0008180)2.57656664
58Calcaneovalgus deformity (HP:0001848)2.57365568
59Exercise-induced muscle cramps (HP:0003710)2.55568885
60Abnormality of the peritoneum (HP:0002585)2.55171645
61Embryonal renal neoplasm (HP:0011794)2.54344971
62Spinal rigidity (HP:0003306)2.53826338
63Neonatal short-limb short stature (HP:0008921)2.53755128
64Nephroblastoma (Wilms tumor) (HP:0002667)2.52453596
65Atrial fibrillation (HP:0005110)2.49242584
66Bicornuate uterus (HP:0000813)2.46722876
67Nasal polyposis (HP:0100582)2.46367962
68Hyporeflexia of lower limbs (HP:0002600)2.45886199
69Metaphyseal irregularity (HP:0003025)2.43789909
70Mucopolysacchariduria (HP:0008155)2.43735108
71Urinary glycosaminoglycan excretion (HP:0003541)2.43735108
72Advanced eruption of teeth (HP:0006288)2.40924725
73Joint stiffness (HP:0001387)2.39780164
74Transposition of the great arteries (HP:0001669)2.37651355
75Abnormal connection of the cardiac segments (HP:0011545)2.37651355
76Abnormal ventriculo-arterial connection (HP:0011563)2.37651355
77Preauricular pit (HP:0004467)2.37264763
78Periauricular skin pits (HP:0100277)2.37264763
79Mutism (HP:0002300)2.36618068
80Renal dysplasia (HP:0000110)2.34527861
81Myopathic facies (HP:0002058)2.33559163
82Calf muscle hypertrophy (HP:0008981)2.31489989
83Deformed tarsal bones (HP:0008119)2.31153910
84Glomerulosclerosis (HP:0000096)2.30732020
85Centrally nucleated skeletal muscle fibers (HP:0003687)2.29678848
86Vertebral compression fractures (HP:0002953)2.28853619
87EMG: myopathic abnormalities (HP:0003458)2.28618001
88Purpura (HP:0000979)2.27291930
89Abnormal pancreas size (HP:0012094)2.23194731
90Abnormality of macrophages (HP:0004311)2.22120126
91Malnutrition (HP:0004395)2.21340542
92Abnormality of the calcaneus (HP:0008364)2.21086706
93Arterial tortuosity (HP:0005116)2.21023821
94Bladder diverticulum (HP:0000015)2.21003624
95Stridor (HP:0010307)2.20749879
96Overgrowth (HP:0001548)2.20490307
97Disinhibition (HP:0000734)2.20445824
98Scapular winging (HP:0003691)2.20188480
99Distal lower limb amyotrophy (HP:0008944)2.19923520
100Primary atrial arrhythmia (HP:0001692)2.19176216
101Testicular neoplasm (HP:0010788)2.18920458
102Upper limb amyotrophy (HP:0009129)2.18501137
103Distal upper limb amyotrophy (HP:0007149)2.18501137
104Supraventricular arrhythmia (HP:0005115)2.18111404
105Vacuolated lymphocytes (HP:0001922)2.18011436
106Dilated cardiomyopathy (HP:0001644)2.16544348
107Obstructive sleep apnea (HP:0002870)2.16148389
108Bundle branch block (HP:0011710)2.15903064
109Amyloidosis (HP:0011034)2.15339356
110Nausea (HP:0002018)2.14730935
111Delayed epiphyseal ossification (HP:0002663)2.13503844
112Anomalous pulmonary venous return (HP:0010772)2.13078638
113Wormian bones (HP:0002645)2.12051739
114Supraventricular tachycardia (HP:0004755)2.10883140
115Cerebral inclusion bodies (HP:0100314)2.10864054
116Vascular tortuosity (HP:0004948)2.10778071
117Abnormality of the pancreatic islet cells (HP:0006476)2.10471756
118Abnormality of endocrine pancreas physiology (HP:0012093)2.10471756
119Gastrointestinal stroma tumor (HP:0100723)2.09153123
120Chorioretinal atrophy (HP:0000533)2.09146135
121Ileus (HP:0002595)2.08699060
122Germ cell neoplasia (HP:0100728)2.08601273
123Difficulty climbing stairs (HP:0003551)2.07348443
124Nephritis (HP:0000123)2.06874759
125Renal duplication (HP:0000075)2.05716699
126Increased variability in muscle fiber diameter (HP:0003557)2.05460419
127Blue sclerae (HP:0000592)2.05453690
128Recurrent gram-negative bacterial infections (HP:0005420)2.05446925
129J-shaped sella turcica (HP:0002680)2.05031957
130Foot dorsiflexor weakness (HP:0009027)2.04341031
131Increased neuronal autofluorescent lipopigment (HP:0002074)2.04246653
132Emphysema (HP:0002097)2.01296117
133Rhabdomyolysis (HP:0003201)2.00842457
134Neck muscle weakness (HP:0000467)1.99542370
135Neoplasm of the liver (HP:0002896)1.99061444
136Interstitial pulmonary disease (HP:0006530)1.98157164
137Broad toe (HP:0001837)1.97190808
138Enlarged penis (HP:0000040)1.93635951
139Enlarged kidneys (HP:0000105)1.92894916
140Abnormality of the pulmonary veins (HP:0011718)1.91686682
141Muscle hypertrophy of the lower extremities (HP:0008968)1.91310361
142Pterygium (HP:0001059)1.90431218
143Hip contracture (HP:0003273)1.90115533
144Abnormality of the foot musculature (HP:0001436)1.90074303
145Frequent falls (HP:0002359)1.88102239
146Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.88030167
147Short 4th metacarpal (HP:0010044)1.88030167
148Aplasia of the musculature (HP:0100854)1.87957587
149Syncope (HP:0001279)1.87766498
150Abnormality of skeletal muscle fiber size (HP:0012084)1.86989758
151Dynein arm defect of respiratory motile cilia (HP:0012255)1.85793161
152Absent/shortened dynein arms (HP:0200106)1.85793161
153Chronic otitis media (HP:0000389)1.85422752
154Generalized aminoaciduria (HP:0002909)1.84815618
155Eczematoid dermatitis (HP:0000976)1.84647184
156Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84639454
157Orchitis (HP:0100796)1.82847615
158Myocardial infarction (HP:0001658)1.82592783
159Increased serum ferritin (HP:0003281)1.82431379
160Shawl scrotum (HP:0000049)1.82388274
161Joint laxity (HP:0001388)1.82109349
162Short femoral neck (HP:0100864)1.81885875
163Distal arthrogryposis (HP:0005684)1.81855721
164Abnormal atrioventricular conduction (HP:0005150)1.81304681
165Ventricular arrhythmia (HP:0004308)1.79524747
166Abnormal lung lobation (HP:0002101)1.79089769
167Ulnar bowing (HP:0003031)1.79038050
168Limb-girdle muscle atrophy (HP:0003797)1.78654987
169Broad palm (HP:0001169)1.77269352
170Preaxial foot polydactyly (HP:0001841)1.76604576
171Hyperextensible skin (HP:0000974)1.76488910
172Persistence of primary teeth (HP:0006335)1.75100638
173Asymmetric septal hypertrophy (HP:0001670)1.74957255
174Camptodactyly of toe (HP:0001836)1.74414803
175Myotonia (HP:0002486)1.74353410
176Aneurysm (HP:0002617)1.74330968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.52263282
2TRIB34.13377202
3MYLK3.65901629
4NME23.60678922
5PKN22.91028293
6MAP2K32.87783904
7PDGFRA2.65306167
8INSRR2.57406931
9IRAK32.35733710
10TIE12.33523144
11MAP3K32.32768271
12ERN12.32737324
13TGFBR12.29261432
14LMTK22.11897509
15TBK12.05263616
16MAP3K141.97351883
17DMPK1.83401450
18FLT31.79292641
19PIK3CA1.77738115
20TGFBR21.71818331
21ICK1.65323768
22PASK1.62767938
23MAP3K131.61346829
24TAOK21.60963126
25LATS21.60819182
26EPHB21.54436974
27GRK71.53792672
28TRPM71.49135583
29NEK91.49123612
30PTK2B1.48882222
31BCKDK1.46943090
32LATS11.38149019
33RIPK41.37668216
34OBSCN1.37485873
35MET1.36121098
36MATK1.35933965
37WNK41.32955232
38PAK21.31115865
39CSK1.29353679
40PIM21.27433838
41BLK1.26987933
42PIK3CG1.24515754
43TYK21.24037662
44ABL21.22516194
45PRPF4B1.20160101
46PTK61.19471985
47PAK41.18705003
48ILK1.17364410
49FER1.16467706
50LRRK21.09917234
51RIPK11.09167621
52MAPK151.07713021
53FGR1.07450164
54WNK11.06648580
55CLK11.05650215
56ROCK11.04251447
57STK38L1.04243433
58JAK31.03599873
59ROCK21.01638740
60FGFR10.99603585
61BMX0.98584881
62MAP3K60.98277265
63TAOK10.97736217
64KDR0.97202831
65MAP3K50.95095378
66PRKD30.94961919
67PTK20.94569977
68MAP3K100.93670796
69IKBKB0.93307461
70PRKAA20.89704089
71PDK30.89583993
72PDK40.89583993
73EPHB10.88166375
74BUB10.88080485
75MOS0.87497329
76PAK30.87178731
77PHKG20.87129197
78PHKG10.87129197
79DDR20.87075141
80TYRO30.85946543
81SIK10.85383697
82MAP3K10.84899854
83EEF2K0.84424293
84NEK10.83805100
85AKT30.83454602
86IKBKE0.83451056
87ZAP700.83212872
88FGFR40.83068175
89PDK20.80440130
90PRKG20.79460270
91CHUK0.78415565
92MAP2K60.77908227
93ERBB30.74239878
94PKN10.72041139
95PRKD20.71736269
96RPS6KA40.71378339
97MAPK40.71201999
98MAP4K10.70271712
99MARK20.69016467
100PRKD10.68629231
101BRAF0.67695910
102MAP3K80.67060690
103CAMK1D0.60951997
104MTOR0.59805278
105SGK20.58487454
106MAPK70.58005641
107MAP2K10.56684428
108CAMK2G0.56378053
109PDPK10.55759118
110MUSK0.54947727
111STK30.54299459
112ZAK0.53925794
113SGK30.52743168
114SMG10.51561185
115MAPKAPK20.51545294
116RPS6KL10.50171743
117RPS6KC10.50171743
118CDC42BPA0.49409439
119KIT0.48760080
120STK40.48261998
121RPS6KA60.47245604
122PDGFRB0.47234703
123DAPK20.44360830
124MAPKAPK30.43324985
125MAP3K70.42944239
126CSF1R0.40931288
127LIMK10.40521484
128CAMK2D0.40226232
129PLK20.38479080
130MAPK120.37936821
131ARAF0.37607024
132NTRK10.36386837
133STK240.36369393
134JAK10.36051009
135TESK10.35515501
136IRAK40.34980461
137PINK10.34839910
138NUAK10.34499091
139DAPK30.34114820
140PAK60.33631529
141LYN0.33286539
142PRKCH0.32624729
143PRKG10.31609702
144EPHA30.31553504
145PRKACG0.31369290
146GSK3A0.30246504
147RPS6KA20.29759931
148CAMK1G0.28886272
149PAK10.27924991
150MKNK10.27701760
151MAP3K110.27260808

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.67481848
2Dilated cardiomyopathy_Homo sapiens_hsa054143.40927993
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.37766296
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.09831738
5Other glycan degradation_Homo sapiens_hsa005112.91840926
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.71593513
7ECM-receptor interaction_Homo sapiens_hsa045122.65519975
8Focal adhesion_Homo sapiens_hsa045102.52245581
9Staphylococcus aureus infection_Homo sapiens_hsa051502.50339349
10Malaria_Homo sapiens_hsa051442.49171246
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.42956433
12Lysosome_Homo sapiens_hsa041422.32222653
13Fatty acid degradation_Homo sapiens_hsa000712.26599094
14Propanoate metabolism_Homo sapiens_hsa006402.16675376
15Rheumatoid arthritis_Homo sapiens_hsa053232.10482199
16Pertussis_Homo sapiens_hsa051332.04062494
17Asthma_Homo sapiens_hsa053101.96968172
18Adherens junction_Homo sapiens_hsa045201.94661020
19Osteoclast differentiation_Homo sapiens_hsa043801.91406079
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88394256
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82927041
22TNF signaling pathway_Homo sapiens_hsa046681.82551489
23Proteoglycans in cancer_Homo sapiens_hsa052051.78987513
24Fatty acid metabolism_Homo sapiens_hsa012121.71455430
25Allograft rejection_Homo sapiens_hsa053301.67393174
26Carbon metabolism_Homo sapiens_hsa012001.66321417
27Viral myocarditis_Homo sapiens_hsa054161.63656315
28Prion diseases_Homo sapiens_hsa050201.63602672
29Leishmaniasis_Homo sapiens_hsa051401.63306922
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61298900
31Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.61173520
32Cardiac muscle contraction_Homo sapiens_hsa042601.52008956
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.51171264
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.41109122
35Small cell lung cancer_Homo sapiens_hsa052221.39670168
36TGF-beta signaling pathway_Homo sapiens_hsa043501.37744689
37Tuberculosis_Homo sapiens_hsa051521.36855249
38Tryptophan metabolism_Homo sapiens_hsa003801.34654151
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34270134
40African trypanosomiasis_Homo sapiens_hsa051431.34219695
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32927379
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32898870
43PPAR signaling pathway_Homo sapiens_hsa033201.30535765
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.29906709
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29450621
46Salmonella infection_Homo sapiens_hsa051321.27314078
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25881637
48Mineral absorption_Homo sapiens_hsa049781.24565468
49Thyroid cancer_Homo sapiens_hsa052161.24192519
50Hippo signaling pathway_Homo sapiens_hsa043901.24098191
51Graft-versus-host disease_Homo sapiens_hsa053321.23076020
52Autoimmune thyroid disease_Homo sapiens_hsa053201.21742482
53Histidine metabolism_Homo sapiens_hsa003401.21490468
54MicroRNAs in cancer_Homo sapiens_hsa052061.18759705
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16155309
56Arginine and proline metabolism_Homo sapiens_hsa003301.16137308
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15765464
58Lysine degradation_Homo sapiens_hsa003101.15375211
59HIF-1 signaling pathway_Homo sapiens_hsa040661.14409819
60Glutathione metabolism_Homo sapiens_hsa004801.13150910
61Prostate cancer_Homo sapiens_hsa052151.12070340
62PI3K-Akt signaling pathway_Homo sapiens_hsa041511.12049766
63Tight junction_Homo sapiens_hsa045301.10534277
64Amoebiasis_Homo sapiens_hsa051461.09731954
65Bladder cancer_Homo sapiens_hsa052191.09597197
66NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07404242
67Phagosome_Homo sapiens_hsa041451.06809346
68Melanoma_Homo sapiens_hsa052181.04434702
69Insulin resistance_Homo sapiens_hsa049311.03202895
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01352503
71Pyruvate metabolism_Homo sapiens_hsa006200.98256750
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97775749
73Legionellosis_Homo sapiens_hsa051340.96930765
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96398508
75Protein digestion and absorption_Homo sapiens_hsa049740.94301796
76Chronic myeloid leukemia_Homo sapiens_hsa052200.90059264
77Basal cell carcinoma_Homo sapiens_hsa052170.90057118
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89839443
79Hematopoietic cell lineage_Homo sapiens_hsa046400.89652852
80Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88463743
81Influenza A_Homo sapiens_hsa051640.88344579
82Butanoate metabolism_Homo sapiens_hsa006500.86869508
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.85795126
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85508893
85Biosynthesis of amino acids_Homo sapiens_hsa012300.84791957
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84747249
87Starch and sucrose metabolism_Homo sapiens_hsa005000.84444413
88Fatty acid elongation_Homo sapiens_hsa000620.84031967
89Hepatitis C_Homo sapiens_hsa051600.83111542
90Notch signaling pathway_Homo sapiens_hsa043300.82624113
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.82127995
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.79954612
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79489318
94Arachidonic acid metabolism_Homo sapiens_hsa005900.78187405
95Fructose and mannose metabolism_Homo sapiens_hsa000510.76518343
96Type I diabetes mellitus_Homo sapiens_hsa049400.76388928
97VEGF signaling pathway_Homo sapiens_hsa043700.75295711
98Galactose metabolism_Homo sapiens_hsa000520.74895615
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.74559994
100Hedgehog signaling pathway_Homo sapiens_hsa043400.73879598
101Complement and coagulation cascades_Homo sapiens_hsa046100.73775967
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.73413686
103Ovarian steroidogenesis_Homo sapiens_hsa049130.72987651
104Pathways in cancer_Homo sapiens_hsa052000.72069938
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71633626
106Rap1 signaling pathway_Homo sapiens_hsa040150.71284335
107Folate biosynthesis_Homo sapiens_hsa007900.71281405
108Thyroid hormone synthesis_Homo sapiens_hsa049180.71064662
109Chemokine signaling pathway_Homo sapiens_hsa040620.68977758
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67476400
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66216563
112Peroxisome_Homo sapiens_hsa041460.66151544
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64846181
114AMPK signaling pathway_Homo sapiens_hsa041520.64351323
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62185919
116Base excision repair_Homo sapiens_hsa034100.61575490
117Endometrial cancer_Homo sapiens_hsa052130.59885278
118Insulin signaling pathway_Homo sapiens_hsa049100.59880254
119HTLV-I infection_Homo sapiens_hsa051660.59117511
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57983225
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57614364
122Sphingolipid metabolism_Homo sapiens_hsa006000.57387988
123Acute myeloid leukemia_Homo sapiens_hsa052210.57295661
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57221006
125Sulfur metabolism_Homo sapiens_hsa009200.55736571
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54589253
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54173251
128Antigen processing and presentation_Homo sapiens_hsa046120.53636652
129B cell receptor signaling pathway_Homo sapiens_hsa046620.53495164
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52371863
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52364746
132Toxoplasmosis_Homo sapiens_hsa051450.51547571
133Phenylalanine metabolism_Homo sapiens_hsa003600.51280013
134Parkinsons disease_Homo sapiens_hsa050120.51268980
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51252702
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50092313
137Collecting duct acid secretion_Homo sapiens_hsa049660.46477972
138GnRH signaling pathway_Homo sapiens_hsa049120.45873426
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45617082
140Neurotrophin signaling pathway_Homo sapiens_hsa047220.44917757
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43486412
142Tyrosine metabolism_Homo sapiens_hsa003500.43088017
143Apoptosis_Homo sapiens_hsa042100.42798493
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41970386
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41656216
146Pancreatic cancer_Homo sapiens_hsa052120.41392792
147Herpes simplex infection_Homo sapiens_hsa051680.41001932
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.40142870
149Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40093491
150Phospholipase D signaling pathway_Homo sapiens_hsa040720.39885630
151Glucagon signaling pathway_Homo sapiens_hsa049220.39882522
152Renin-angiotensin system_Homo sapiens_hsa046140.39679846
153Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39405302
154Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39224067
155Non-small cell lung cancer_Homo sapiens_hsa052230.39148400
156Glioma_Homo sapiens_hsa052140.36330713
157Shigellosis_Homo sapiens_hsa051310.34874119
158Prolactin signaling pathway_Homo sapiens_hsa049170.34661290
159Melanogenesis_Homo sapiens_hsa049160.34241409
160Renin secretion_Homo sapiens_hsa049240.34182380
161Fat digestion and absorption_Homo sapiens_hsa049750.33077039
162beta-Alanine metabolism_Homo sapiens_hsa004100.33018288
163Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28644072

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