REN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1flavonoid metabolic process (GO:0009812)7.89635564
2low-density lipoprotein particle clearance (GO:0034383)7.57052748
3alpha-linolenic acid metabolic process (GO:0036109)6.89793033
4biotin metabolic process (GO:0006768)6.43038150
5response to phenylpropanoid (GO:0080184)6.33722514
6citrulline biosynthetic process (GO:0019240)6.25769105
7fatty-acyl-CoA biosynthetic process (GO:0046949)5.97633710
8L-serine transport (GO:0015825)5.72580052
9acyl-CoA biosynthetic process (GO:0071616)5.36733577
10thioester biosynthetic process (GO:0035384)5.36733577
11fatty-acyl-CoA metabolic process (GO:0035337)5.25051545
12cellular glucuronidation (GO:0052695)5.21363383
13white fat cell differentiation (GO:0050872)5.10772365
14fatty acid homeostasis (GO:0055089)5.06928897
15triglyceride biosynthetic process (GO:0019432)4.99431638
16triglyceride catabolic process (GO:0019433)4.94196785
17regulation of transforming growth factor beta1 production (GO:0032908)4.89096034
18serine transport (GO:0032329)4.88327279
19long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.84003535
20long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.79968805
21glucuronate metabolic process (GO:0019585)4.75399397
22uronic acid metabolic process (GO:0006063)4.75399397
23tolerance induction (GO:0002507)4.75335004
24negative regulation of fatty acid transport (GO:2000192)4.72540238
25neutral lipid biosynthetic process (GO:0046460)4.72334108
26acylglycerol biosynthetic process (GO:0046463)4.72334108
27regulation of interleukin-5 production (GO:0032674)4.61629732
28regulation of cholesterol storage (GO:0010885)4.52761426
29fatty acid transmembrane transport (GO:1902001)4.51617583
30citrulline metabolic process (GO:0000052)4.40984165
31daunorubicin metabolic process (GO:0044597)4.39702481
32polyketide metabolic process (GO:0030638)4.39702481
33doxorubicin metabolic process (GO:0044598)4.39702481
34brown fat cell differentiation (GO:0050873)4.39107237
35neutral lipid catabolic process (GO:0046461)4.35306668
36acylglycerol catabolic process (GO:0046464)4.35306668
37carnitine shuttle (GO:0006853)4.34907738
38negative regulation of interleukin-10 production (GO:0032693)4.32949325
39regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.28241822
40aminoglycoside antibiotic metabolic process (GO:0030647)4.23955767
41positive regulation of transforming growth factor beta production (GO:0071636)4.15949704
42valine metabolic process (GO:0006573)4.14486394
43regulation of sequestering of triglyceride (GO:0010889)4.06854332
44cellular response to lithium ion (GO:0071285)4.06276740
45negative regulation of B cell mediated immunity (GO:0002713)4.02139821
46negative regulation of immunoglobulin mediated immune response (GO:0002890)4.02139821
47acetyl-CoA metabolic process (GO:0006084)4.00914185
48coenzyme A biosynthetic process (GO:0015937)4.00332052
49peptidyl-arginine modification (GO:0018195)3.89341179
50regulation of regulatory T cell differentiation (GO:0045589)3.89224944
51negative regulation of histone acetylation (GO:0035067)3.87429394
52positive regulation of glomerulus development (GO:0090193)3.84610604
53desmosome organization (GO:0002934)3.81700400
54regulation of glycogen (starch) synthase activity (GO:2000465)3.74437275
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.71392167
56glucose 6-phosphate metabolic process (GO:0051156)3.67454099
57diacylglycerol metabolic process (GO:0046339)3.64558100
58regulation of cholesterol biosynthetic process (GO:0045540)3.59251343
59linoleic acid metabolic process (GO:0043651)3.57067622
60phosphatidylserine acyl-chain remodeling (GO:0036150)3.50303749
61carnitine transmembrane transport (GO:1902603)3.49896829
62regulation of chronic inflammatory response (GO:0002676)3.48202349
63positive regulation of tolerance induction (GO:0002645)3.44495863
64diterpenoid biosynthetic process (GO:0016102)3.42590573
65negative regulation of metanephros development (GO:0072217)3.39932046
66oxaloacetate metabolic process (GO:0006107)3.37861571
67negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.31619778
68triglyceride metabolic process (GO:0006641)3.28390454
69tricarboxylic acid metabolic process (GO:0072350)3.26604896
70acyl-CoA metabolic process (GO:0006637)3.25559965
71thioester metabolic process (GO:0035383)3.25559965
72regulation of cholesterol homeostasis (GO:2000188)3.24556745
73glycerolipid catabolic process (GO:0046503)3.22311762
74cyclooxygenase pathway (GO:0019371)3.22198882
75carnitine transport (GO:0015879)3.21098677
76amino-acid betaine transport (GO:0015838)3.21098677
77progesterone metabolic process (GO:0042448)3.21052788
78negative regulation of peptidyl-lysine acetylation (GO:2000757)3.19839445
79NADH metabolic process (GO:0006734)3.19826255
80activation of Rac GTPase activity (GO:0032863)3.16678049
81glucose catabolic process (GO:0006007)3.13524957
82plasma lipoprotein particle clearance (GO:0034381)3.13403754
83coenzyme A metabolic process (GO:0015936)3.10511036
84phosphatidic acid metabolic process (GO:0046473)3.09576083
85phosphatidic acid biosynthetic process (GO:0006654)3.09576083
86regulation of isotype switching to IgG isotypes (GO:0048302)3.08813241
87regulation of clathrin-mediated endocytosis (GO:2000369)3.04105245
88phospholipid homeostasis (GO:0055091)3.02842583
89acylglycerol metabolic process (GO:0006639)3.02198792
90alditol phosphate metabolic process (GO:0052646)3.00329981
91negative regulation of interleukin-2 production (GO:0032703)2.99394529
92positive regulation of T cell differentiation in thymus (GO:0033089)2.98746210
93protein localization to microtubule (GO:0035372)2.98635874
94mesodermal cell differentiation (GO:0048333)2.98232624
95phosphatidylinositol acyl-chain remodeling (GO:0036149)2.97908611
96face development (GO:0060324)2.97636248
97positive regulation of hormone biosynthetic process (GO:0046886)2.97424934
98pentose-phosphate shunt (GO:0006098)2.96819927
99neutral lipid metabolic process (GO:0006638)2.95942758
100regulation of histone deacetylation (GO:0031063)2.95155547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.58386602
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.08217471
3ZNF263_19887448_ChIP-Seq_K562_Human4.43834706
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.64983564
5PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.84531220
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76981761
7* PPAR_26484153_Chip-Seq_NCI-H1993_Human2.75859926
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63215025
9TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.52487409
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.50998794
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.41388823
12KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.32520893
13CDX2_20551321_ChIP-Seq_CACO-2_Human2.25114215
14RACK7_27058665_Chip-Seq_MCF-7_Human2.18727825
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.17042309
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.13855724
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13157777
18* LXR_22292898_ChIP-Seq_THP-1_Human2.11627881
19E2F7_22180533_ChIP-Seq_HELA_Human2.03328794
20* SOX2_20726797_ChIP-Seq_SW620_Human1.99571344
21KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.96519333
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87991608
23P63_26484246_Chip-Seq_KERATINOCYTES_Human1.82197753
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.79009365
25CLOCK_20551151_ChIP-Seq_293T_Human1.73993293
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.73119091
27SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71049672
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70596439
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.63487892
30ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.59567637
31KLF5_25053715_ChIP-Seq_YYC3_Human1.58114118
32ATF3_27146783_Chip-Seq_COLON_Human1.55128005
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.54358511
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52019962
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49480959
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.48126728
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.48071493
38BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.46665158
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44014470
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44014470
41NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37622552
42GATA6_25053715_ChIP-Seq_YYC3_Human1.37495858
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31865292
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31475430
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.23496388
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.22078398
47GATA4_25053715_ChIP-Seq_YYC3_Human1.22075532
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.21964045
49KDM2B_26808549_Chip-Seq_K562_Human1.21956647
50* TP63_22573176_ChIP-Seq_HFKS_Human1.20008211
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17675841
52P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17530261
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.17083524
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16860772
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14553871
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13696237
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09955450
58TP53_22127205_ChIP-Seq_IMR90_Human1.08676209
59* GATA3_24758297_ChIP-Seq_MCF-7_Human1.08634141
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08333217
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07603717
62SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06631101
63NCOR1_26117541_ChIP-Seq_K562_Human1.06373355
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06249846
65TBX20_22080862_ChIP-Seq_HEART_Mouse1.05225207
66TBX20_22328084_ChIP-Seq_HEART_Mouse1.05225207
67TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02488640
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01615293
69* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.01133808
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00799675
71P68_20966046_ChIP-Seq_HELA_Human1.00783623
72ESR1_21235772_ChIP-Seq_MCF-7_Human0.99848813
73AR_21909140_ChIP-Seq_LNCAP_Human0.98850567
74SMC4_20622854_ChIP-Seq_HELA_Human0.98406528
75GATA1_22025678_ChIP-Seq_K562_Human0.98123702
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97755217
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.97657445
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95189722
79SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94860634
80HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92189058
81ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91770355
82NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90947392
83TCF7_22412390_ChIP-Seq_EML_Mouse0.89485652
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.84944643
85TET1_21451524_ChIP-Seq_MESCs_Mouse0.83268805
86ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83233667
87PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82988023
88* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82916505
89KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82484141
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81477218
91CTCF_27219007_Chip-Seq_ERYTHROID_Human0.80795724
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80097064
93GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79744541
94CREB1_26743006_Chip-Seq_LNCaP_Human0.79573690
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79202125
96CHD1_26751641_Chip-Seq_LNCaP_Human0.78719283
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78466752
98UBF1/2_26484160_Chip-Seq_HMECs_Human0.78353405
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.78343866
100FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.77196917

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.53555798
2MP0004185_abnormal_adipocyte_glucose5.43756839
3MP0005666_abnormal_adipose_tissue4.62448921
4MP0010234_abnormal_vibrissa_follicle4.49008652
5MP0004130_abnormal_muscle_cell3.66947993
6MP0000566_synostosis3.23534006
7MP0003315_abnormal_perineum_morphology3.17376016
8MP0002971_abnormal_brown_adipose2.85391626
9MP0003868_abnormal_feces_composition2.84503710
10MP0005375_adipose_tissue_phenotype2.77105008
11MP0001661_extended_life_span2.74804842
12MP0002796_impaired_skin_barrier2.71942777
13MP0003705_abnormal_hypodermis_morpholog2.58776210
14MP0001873_stomach_inflammation2.52701446
15MP0000465_gastrointestinal_hemorrhage2.29184461
16MP0002970_abnormal_white_adipose2.16298456
17MP0005501_abnormal_skin_physiology2.09931475
18MP0003011_delayed_dark_adaptation1.91412230
19MP0003453_abnormal_keratinocyte_physiol1.87796698
20MP0004947_skin_inflammation1.75983034
21MP0006138_congestive_heart_failure1.74924049
22MP0004264_abnormal_extraembryonic_tissu1.73925041
23MP0004272_abnormal_basement_membrane1.73601783
24MP0004782_abnormal_surfactant_physiolog1.73326480
25MP0005451_abnormal_body_composition1.71814903
26MP0002139_abnormal_hepatobiliary_system1.68173975
27MP0005334_abnormal_fat_pad1.65589743
28MP0009115_abnormal_fat_cell1.63361485
29MP0002118_abnormal_lipid_homeostasis1.60101463
30MP0000534_abnormal_ureter_morphology1.56544516
31MP0005076_abnormal_cell_differentiation1.56103442
32MP0003191_abnormal_cellular_cholesterol1.55601938
33MP0003959_abnormal_lean_body1.53710369
34MP0005448_abnormal_energy_balance1.49172557
35MP0001216_abnormal_epidermal_layer1.46785183
36MP0002249_abnormal_larynx_morphology1.43476714
37MP0005365_abnormal_bile_salt1.42519175
38MP0010329_abnormal_lipoprotein_level1.41417057
39MP0005535_abnormal_body_temperature1.38908673
40MP0001849_ear_inflammation1.33646420
41MP0001851_eye_inflammation1.31387788
42MP0000467_abnormal_esophagus_morphology1.28725712
43MP0000003_abnormal_adipose_tissue1.25483171
44MP0005248_abnormal_Harderian_gland1.21861640
45MP0000609_abnormal_liver_physiology1.21716883
46MP0003942_abnormal_urinary_system1.19822431
47MP0004019_abnormal_vitamin_homeostasis1.15784051
48MP0002060_abnormal_skin_morphology1.09430264
49MP0002277_abnormal_respiratory_mucosa1.09027198
50MP0003941_abnormal_skin_development1.02593839
51MP0002098_abnormal_vibrissa_morphology1.01104886
52MP0005332_abnormal_amino_acid0.99513575
53MP0005367_renal/urinary_system_phenotyp0.98294355
54MP0000516_abnormal_urinary_system0.98294355
55MP0005452_abnormal_adipose_tissue0.98123501
56MP0003828_pulmonary_edema0.96785553
57MP0000579_abnormal_nail_morphology0.89349211
58MP0009643_abnormal_urine_homeostasis0.88549446
59MP0010771_integument_phenotype0.87275985
60MP0005377_hearing/vestibular/ear_phenot0.86748526
61MP0003878_abnormal_ear_physiology0.86748526
62MP0010030_abnormal_orbit_morphology0.84272305
63MP0009931_abnormal_skin_appearance0.83886162
64MP0001664_abnormal_digestion0.80071092
65MP0006036_abnormal_mitochondrial_physio0.78981923
66MP0002078_abnormal_glucose_homeostasis0.76038131
67MP0008438_abnormal_cutaneous_collagen0.74996779
68MP0003953_abnormal_hormone_level0.73237035
69MP0010630_abnormal_cardiac_muscle0.71008527
70MP0005058_abnormal_lysosome_morphology0.70332248
71MP0002089_abnormal_postnatal_growth/wei0.69658826
72MP0001270_distended_abdomen0.69463833
73MP0010678_abnormal_skin_adnexa0.69027395
74MP0001727_abnormal_embryo_implantation0.67167842
75MP0003115_abnormal_respiratory_system0.66926963
76MP0009672_abnormal_birth_weight0.66817706
77MP0005275_abnormal_skin_tensile0.66678189
78MP0003283_abnormal_digestive_organ0.66660256
79MP0009780_abnormal_chondrocyte_physiolo0.66658136
80MP0001881_abnormal_mammary_gland0.66477431
81MP0000013_abnormal_adipose_tissue0.66466828
82MP0003943_abnormal_hepatobiliary_system0.65157467
83MP0009840_abnormal_foam_cell0.61284393
84MP0008875_abnormal_xenobiotic_pharmacok0.60363478
85MP0003866_abnormal_defecation0.59761518
86MP0003566_abnormal_cell_adhesion0.57898401
87MP0005319_abnormal_enzyme/_coenzyme0.57444237
88MP0000598_abnormal_liver_morphology0.56703987
89MP0000537_abnormal_urethra_morphology0.56257791
90MP0008004_abnormal_stomach_pH0.55736932
91MP0005220_abnormal_exocrine_pancreas0.55596593
92MP0005584_abnormal_enzyme/coenzyme_acti0.54298741
93MP0002136_abnormal_kidney_physiology0.53964248
94MP0003950_abnormal_plasma_membrane0.53425941
95MP0001340_abnormal_eyelid_morphology0.50759517
96MP0002909_abnormal_adrenal_gland0.50057548
97MP0001944_abnormal_pancreas_morphology0.50010722
98MP0004197_abnormal_fetal_growth/weight/0.49936867
99MP0005385_cardiovascular_system_phenoty0.49934022
100MP0001544_abnormal_cardiovascular_syste0.49934022

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)7.36345660
2Autoimmune hemolytic anemia (HP:0001890)5.67302178
3Subcapsular cataract (HP:0000523)4.93090218
4Hemorrhage of the eye (HP:0011885)4.46541555
5* Focal segmental glomerulosclerosis (HP:0000097)4.04491853
6Acanthosis nigricans (HP:0000956)4.00507303
7Fragile skin (HP:0001030)3.77803329
8Hyperactive renin-angiotensin system (HP:0000841)3.60806931
9Hypertriglyceridemia (HP:0002155)3.51961517
10Polar cataract (HP:0010696)3.51363885
11* Glomerulosclerosis (HP:0000096)3.26540985
12Pigmentary retinal degeneration (HP:0001146)2.98591598
13Progressive sensorineural hearing impairment (HP:0000408)2.91565239
14Growth hormone excess (HP:0000845)2.90454003
15Short nail (HP:0001799)2.89808060
16Ankyloglossia (HP:0010296)2.86460962
17Pili torti (HP:0003777)2.75419627
18Abnormality of oral frenula (HP:0000190)2.75072587
19Abnormality of fatty-acid metabolism (HP:0004359)2.69762864
20Progressive hearing impairment (HP:0001730)2.69433994
21Type I diabetes mellitus (HP:0100651)2.69341223
22Villous atrophy (HP:0011473)2.69244865
23Abnormality of small intestinal villus morphology (HP:0011472)2.69244865
24Insulin resistance (HP:0000855)2.67821262
25Renal salt wasting (HP:0000127)2.66240886
26Distal lower limb amyotrophy (HP:0008944)2.62524383
27Osteolytic defects of the hand bones (HP:0009699)2.52272726
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.52272726
29Protrusio acetabuli (HP:0003179)2.50457738
30Proximal tubulopathy (HP:0000114)2.48494371
31Hypercholesterolemia (HP:0003124)2.44712836
32Gastrointestinal dysmotility (HP:0002579)2.43973934
33Hyperthyroidism (HP:0000836)2.43139134
34Rhabdomyolysis (HP:0003201)2.39982766
35Hyperacusis (HP:0010780)2.39637804
36Atrophic scars (HP:0001075)2.39629388
37Hyperaldosteronism (HP:0000859)2.39246862
38* Potter facies (HP:0002009)2.37956619
39* Facial shape deformation (HP:0011334)2.37956619
40Myocardial infarction (HP:0001658)2.32048808
41Mildly elevated creatine phosphokinase (HP:0008180)2.29205200
42Bilateral sensorineural hearing impairment (HP:0008619)2.26366256
43Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25838325
44Skin nodule (HP:0200036)2.25072938
45Alopecia of scalp (HP:0002293)2.24655806
46Seborrheic dermatitis (HP:0001051)2.23492626
47Myoglobinuria (HP:0002913)2.22739290
48Neonatal death (HP:0003811)2.20588330
49Axonal loss (HP:0003447)2.15545133
50Tongue fasciculations (HP:0001308)2.15245710
51Esophageal varix (HP:0002040)2.13545329
52Thin bony cortex (HP:0002753)2.13522857
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.13254983
54Broad face (HP:0000283)2.12170461
55Patellar dislocation (HP:0002999)2.09447032
56Nausea (HP:0002018)2.06625638
57Bicornuate uterus (HP:0000813)2.05306721
58Hyperkalemia (HP:0002153)2.00154040
59Septate vagina (HP:0001153)1.99468735
60Rickets (HP:0002748)1.98271292
61Cholecystitis (HP:0001082)1.98033609
62Abnormal gallbladder physiology (HP:0012438)1.98033609
63Bowel incontinence (HP:0002607)1.97221083
64Premature rupture of membranes (HP:0001788)1.97192989
65Periodontitis (HP:0000704)1.97129023
66Easy fatigability (HP:0003388)1.95407139
67Decreased subcutaneous fat (HP:0001002)1.95091486
68Male infertility (HP:0003251)1.94746597
69Vaginal fistula (HP:0004320)1.94523531
70Abnormality of the distal phalanges of the toes (HP:0010182)1.93726042
71Congenital ichthyosiform erythroderma (HP:0007431)1.91417581
72High anterior hairline (HP:0009890)1.90975452
73Aplasia/Hypoplasia of the clavicles (HP:0006710)1.87357760
74Tetraparesis (HP:0002273)1.86360320
75Abnormal large intestine physiology (HP:0012700)1.85315091
76Back pain (HP:0003418)1.83285875
77Curly hair (HP:0002212)1.82297589
78Insulin-resistant diabetes mellitus (HP:0000831)1.82057522
79Hypoalphalipoproteinemia (HP:0003233)1.81798548
80Plantar hyperkeratosis (HP:0007556)1.77984906
81Erythema (HP:0010783)1.77590246
82Muscle fibrillation (HP:0010546)1.76017049
83Trismus (HP:0000211)1.74833444
84Fragile nails (HP:0001808)1.74713724
85Mitral stenosis (HP:0001718)1.73051587
86Onycholysis (HP:0001806)1.72940219
87Testicular neoplasm (HP:0010788)1.71194119
88Xanthomatosis (HP:0000991)1.70734541
89Hyperammonemia (HP:0001987)1.68698363
90Advanced eruption of teeth (HP:0006288)1.68000221
91Blepharitis (HP:0000498)1.67518227
92Abnormal hair laboratory examination (HP:0003328)1.66424709
93Renovascular hypertension (HP:0100817)1.65842000
94Reticulocytosis (HP:0001923)1.65597369
95Vertebral compression fractures (HP:0002953)1.65594705
96Macroorchidism (HP:0000053)1.65137735
97Aplasia cutis congenita (HP:0001057)1.63451406
98Coronal craniosynostosis (HP:0004440)1.62760200
99Stridor (HP:0010307)1.62206041
100Hypophosphatemic rickets (HP:0004912)1.61377311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.61406288
2IRAK35.46104808
3SIK14.61667365
4TRIB34.49604383
5NME23.03344001
6DDR22.77603850
7LMTK22.54288634
8MST1R2.38699381
9RIPK12.07530148
10PDGFRA2.03004644
11CAMK1D1.83563198
12ICK1.80119014
13PAK41.77994316
14CDK81.66157212
15MET1.64820702
16TYRO31.61137852
17PKN21.60856770
18STK241.60831158
19MATK1.57295080
20PRKG21.44435516
21PRKAA21.25736767
22MAP3K61.25235963
23PTK61.25093884
24PTK21.24771927
25CAMK1G1.24488054
26ERN11.23038927
27MAP2K31.22133917
28IRAK21.16702172
29EIF2AK11.13459663
30RPS6KB21.12057190
31STK391.08154174
32EPHB11.07799391
33EPHB21.07051613
34BMX1.04558818
35TAOK11.02175063
36MAP2K10.99630302
37LATS10.98620864
38CDK90.97417321
39LATS20.96265521
40RPS6KA40.91061256
41SMG10.90092026
42MAP2K60.89965988
43NTRK10.87824282
44SCYL20.86801192
45MAP2K40.86537614
46TAOK20.85848535
47MAP3K20.83758359
48MAP3K30.83389829
49PDPK10.81766614
50CDK70.80213150
51CDK60.73167465
52MTOR0.71807530
53CDK40.66298666
54FER0.65686426
55ILK0.65415311
56WNK40.65332168
57STK380.64740092
58KSR20.58396675
59PRKAA10.57211735
60ALK0.55619897
61CDK120.52596760
62RET0.49449435
63IRAK10.49415884
64CHEK20.47444660
65PDGFRB0.46372503
66MAP3K110.45696249
67PHKG20.45311189
68PHKG10.45311189
69IRAK40.43502841
70MAP3K10.41776203
71MYLK0.40664430
72MAP4K10.39220895
73WNK10.36622252
74PLK40.36505293
75MUSK0.34951973
76CAMK10.33581815
77OXSR10.33548349
78STK30.32846084
79TESK10.32171620
80FLT30.30602677
81GSK3A0.28090296
82AKT30.27909828
83PRKD20.26854431
84IGF1R0.26835143
85DYRK30.26682234
86LRRK20.26640917
87MAP2K20.25847930
88FGR0.25726277
89SGK30.24367863
90ABL20.24107485
91TBK10.24105660
92PDK10.22576210
93CAMK2G0.22232498
94CDC42BPA0.20293037
95MAP3K50.19636615
96NEK90.18577179
97MAPKAPK20.17763184
98CSNK1A10.17283652
99CDK10.17249212
100MAP3K90.17124044

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.80580042
2Phenylalanine metabolism_Homo sapiens_hsa003604.45551573
3PPAR signaling pathway_Homo sapiens_hsa033203.28532289
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.16337557
5Fatty acid metabolism_Homo sapiens_hsa012123.09794606
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63230793
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.50050591
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.42330019
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34195506
10Fatty acid elongation_Homo sapiens_hsa000622.20132354
11Tyrosine metabolism_Homo sapiens_hsa003502.19105031
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.15693759
13Starch and sucrose metabolism_Homo sapiens_hsa005002.07157534
14beta-Alanine metabolism_Homo sapiens_hsa004102.04126366
15Pyruvate metabolism_Homo sapiens_hsa006202.03621623
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90513692
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.90437012
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.89832083
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89183826
20Propanoate metabolism_Homo sapiens_hsa006401.88433704
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.78122953
22Histidine metabolism_Homo sapiens_hsa003401.65275012
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.61438603
24Fat digestion and absorption_Homo sapiens_hsa049751.61403059
25Retinol metabolism_Homo sapiens_hsa008301.60178082
26Chemical carcinogenesis_Homo sapiens_hsa052041.59546812
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59311261
28Fatty acid degradation_Homo sapiens_hsa000711.55156615
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.38903236
30Sulfur relay system_Homo sapiens_hsa041221.38768305
31Steroid biosynthesis_Homo sapiens_hsa001001.36988068
32Glycerolipid metabolism_Homo sapiens_hsa005611.30492936
33One carbon pool by folate_Homo sapiens_hsa006701.28195273
34Pentose phosphate pathway_Homo sapiens_hsa000301.27411659
35Carbon metabolism_Homo sapiens_hsa012001.19492405
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12293371
37AMPK signaling pathway_Homo sapiens_hsa041521.09279602
38Insulin signaling pathway_Homo sapiens_hsa049101.03394220
39Glycerophospholipid metabolism_Homo sapiens_hsa005641.02044459
40Glutathione metabolism_Homo sapiens_hsa004801.01512447
41ECM-receptor interaction_Homo sapiens_hsa045120.97298414
42Arachidonic acid metabolism_Homo sapiens_hsa005900.96631477
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96263915
44Biosynthesis of amino acids_Homo sapiens_hsa012300.73622118
45Insulin resistance_Homo sapiens_hsa049310.72480666
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71551422
47Peroxisome_Homo sapiens_hsa041460.67380943
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62220874
49Thyroid cancer_Homo sapiens_hsa052160.60042135
50Glucagon signaling pathway_Homo sapiens_hsa049220.56519335
51Sulfur metabolism_Homo sapiens_hsa009200.56331447
52Adherens junction_Homo sapiens_hsa045200.55976008
53Focal adhesion_Homo sapiens_hsa045100.55678148
54Linoleic acid metabolism_Homo sapiens_hsa005910.55623295
55Small cell lung cancer_Homo sapiens_hsa052220.54377576
56Butanoate metabolism_Homo sapiens_hsa006500.53518252
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.48866252
58Chronic myeloid leukemia_Homo sapiens_hsa052200.48474904
59Arginine biosynthesis_Homo sapiens_hsa002200.48465781
60Ovarian steroidogenesis_Homo sapiens_hsa049130.47077573
61N-Glycan biosynthesis_Homo sapiens_hsa005100.45942691
62Prion diseases_Homo sapiens_hsa050200.42144896
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40706333
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40684628
65Fructose and mannose metabolism_Homo sapiens_hsa000510.39295884
66Galactose metabolism_Homo sapiens_hsa000520.36413570
67Renal cell carcinoma_Homo sapiens_hsa052110.35556289
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35368009
69Notch signaling pathway_Homo sapiens_hsa043300.35323996
70Base excision repair_Homo sapiens_hsa034100.33080937
71Acute myeloid leukemia_Homo sapiens_hsa052210.31771131
72Tight junction_Homo sapiens_hsa045300.31417490
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28256904
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25206544
75Vitamin B6 metabolism_Homo sapiens_hsa007500.23019251
76Metabolic pathways_Homo sapiens_hsa011000.22867871
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22636572
78VEGF signaling pathway_Homo sapiens_hsa043700.22349386
79* Renin-angiotensin system_Homo sapiens_hsa046140.21984553
80Proteoglycans in cancer_Homo sapiens_hsa052050.21924758
81Hepatitis C_Homo sapiens_hsa051600.20610667
82Basal cell carcinoma_Homo sapiens_hsa052170.19546243
83ErbB signaling pathway_Homo sapiens_hsa040120.18204137
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17707765
85Inositol phosphate metabolism_Homo sapiens_hsa005620.17467493
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13306862
87Bile secretion_Homo sapiens_hsa049760.13294077
88Type II diabetes mellitus_Homo sapiens_hsa049300.12687437
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12400192
90Shigellosis_Homo sapiens_hsa051310.12236893
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12221032
92Amoebiasis_Homo sapiens_hsa051460.10987595
93Hippo signaling pathway_Homo sapiens_hsa043900.10430992
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.10410466
95Thyroid hormone synthesis_Homo sapiens_hsa049180.10304316
96Folate biosynthesis_Homo sapiens_hsa007900.10112792
97Lysine degradation_Homo sapiens_hsa003100.10079291
98DNA replication_Homo sapiens_hsa030300.08880122
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.08614244
100Prolactin signaling pathway_Homo sapiens_hsa049170.08323318

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