RENBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular extravasation (GO:0045123)6.47724531
2microglial cell activation (GO:0001774)5.39090385
3positive regulation of chemokine biosynthetic process (GO:0045080)5.32775495
4regulation of MHC class II biosynthetic process (GO:0045346)5.12895169
5protoporphyrinogen IX biosynthetic process (GO:0006782)4.90940841
6regulation of chemokine biosynthetic process (GO:0045073)4.77366536
7positive regulation of histone deacetylation (GO:0031065)4.70595415
8reactive oxygen species biosynthetic process (GO:1903409)4.62870217
9negative regulation of interleukin-12 production (GO:0032695)4.43309914
10positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.32649920
11purine deoxyribonucleotide catabolic process (GO:0009155)4.21660699
12regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.21657658
13regulation of growth of symbiont in host (GO:0044126)4.07930158
14negative regulation of growth of symbiont in host (GO:0044130)4.07930158
15negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.07930158
16modulation of growth of symbiont involved in interaction with host (GO:0044144)4.07930158
17neutrophil activation involved in immune response (GO:0002283)4.01546644
18macrophage activation (GO:0042116)3.98854849
19neutrophil mediated immunity (GO:0002446)3.93860049
20positive regulation of protein deacetylation (GO:0090312)3.85861107
21positive regulation of gamma-delta T cell activation (GO:0046645)3.83165794
22formation of translation preinitiation complex (GO:0001731)3.81817098
23macrophage chemotaxis (GO:0048246)3.71699818
24proteasome assembly (GO:0043248)3.71517842
25protoporphyrinogen IX metabolic process (GO:0046501)3.71461922
26purine nucleobase biosynthetic process (GO:0009113)3.67038136
27negative regulation of phagocytosis (GO:0050765)3.55226453
28nucleobase biosynthetic process (GO:0046112)3.50575285
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50474282
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.43842804
31phagosome maturation (GO:0090382)3.39096493
32positive regulation of antigen processing and presentation (GO:0002579)3.37082132
33modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36273658
34positive regulation by organism of defense response of other organism involved in symbiotic interact3.36273658
35modulation by symbiont of host immune response (GO:0052553)3.36273658
36positive regulation by symbiont of host defense response (GO:0052509)3.36273658
37modulation by symbiont of host defense response (GO:0052031)3.36273658
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36273658
39immunoglobulin mediated immune response (GO:0016064)3.34448765
40negative regulation of interleukin-2 production (GO:0032703)3.29974329
41folic acid transport (GO:0015884)3.29797243
42antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.29581947
43regulation of mast cell degranulation (GO:0043304)3.28770386
44negative regulation of cell killing (GO:0031342)3.27794453
45negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.27794453
46ribosome assembly (GO:0042255)3.27644695
47* amino sugar catabolic process (GO:0046348)3.26375479
48myeloid leukocyte mediated immunity (GO:0002444)3.25352494
49positive regulation of mast cell activation (GO:0033005)3.24978216
50myeloid dendritic cell differentiation (GO:0043011)3.21966971
51natural killer cell mediated immunity (GO:0002228)3.21589400
52natural killer cell mediated cytotoxicity (GO:0042267)3.21589400
53positive regulation of mast cell degranulation (GO:0043306)3.21461958
54positive regulation of mast cell activation involved in immune response (GO:0033008)3.21461958
55positive regulation of interferon-alpha production (GO:0032727)3.20503207
56negative regulation of interleukin-1 beta production (GO:0032691)3.18352650
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.16143126
58angiotensin maturation (GO:0002003)3.15688298
59regulation of antigen processing and presentation (GO:0002577)3.13019296
60response to peptidoglycan (GO:0032494)3.12743277
61cellular response to thyroid hormone stimulus (GO:0097067)3.12029150
62negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08305516
63regulation of mast cell activation (GO:0033003)3.06464688
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05138654
65folic acid metabolic process (GO:0046655)3.04979720
66dendritic cell differentiation (GO:0097028)3.04253450
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04045760
68DNA deamination (GO:0045006)3.03897177
69regulation of mast cell activation involved in immune response (GO:0033006)3.03060104
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.02627647
71regulation of mononuclear cell migration (GO:0071675)3.01639118
72B cell mediated immunity (GO:0019724)3.01218041
73killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.00891772
74disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.00891772
75myeloid dendritic cell activation (GO:0001773)2.99945801
76regulation of interferon-alpha production (GO:0032647)2.99856673
77myeloid cell activation involved in immune response (GO:0002275)2.99832045
78T-helper 1 type immune response (GO:0042088)2.99746692
79lytic vacuole organization (GO:0080171)2.97871954
80lysosome organization (GO:0007040)2.97871954
81interferon-gamma secretion (GO:0072643)2.96751204
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95724981
83base-excision repair, AP site formation (GO:0006285)2.94753012
84* N-acetylneuraminate metabolic process (GO:0006054)2.93964229
85signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93611781
86signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93611781
87signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93611781
88detection of other organism (GO:0098543)2.93296028
89mitotic metaphase plate congression (GO:0007080)2.93236069
90intracellular pH reduction (GO:0051452)2.92838966
91ribosome biogenesis (GO:0042254)2.92756119
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.91507969
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91507969
94regulation of gamma-delta T cell activation (GO:0046643)2.91404075
95positive regulation of interferon-beta production (GO:0032728)2.91272661
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90387490
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89885661
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89885661
99regulation of interferon-beta biosynthetic process (GO:0045357)2.88842254
100cellular response to cadmium ion (GO:0071276)2.88457041
101signal transduction involved in cell cycle checkpoint (GO:0072395)2.85271989
102glycolipid catabolic process (GO:0019377)2.84367578
103response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84309517
104response to host immune response (GO:0052572)2.84309517
105rRNA modification (GO:0000154)2.82642154
106defense response to protozoan (GO:0042832)2.82002582
107response to protozoan (GO:0001562)2.81432332
108negative regulation of interleukin-1 production (GO:0032692)2.80779578
109interferon-gamma-mediated signaling pathway (GO:0060333)2.78889771
110detection of molecule of bacterial origin (GO:0032490)2.78394964
111DNA replication checkpoint (GO:0000076)2.78374072
112detection of bacterium (GO:0016045)2.77749185
113negative regulation of cytokine production involved in immune response (GO:0002719)2.77622508
114myeloid leukocyte activation (GO:0002274)2.76131149
115negative regulation of ligase activity (GO:0051352)2.75869380
116negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.75869380
117telomere maintenance via recombination (GO:0000722)2.73136034
118centriole replication (GO:0007099)2.72934281
119regulation of cellular amino acid metabolic process (GO:0006521)2.71481526
120response to muramyl dipeptide (GO:0032495)2.70290867
121detection of external biotic stimulus (GO:0098581)2.69958166
122telomere maintenance via semi-conservative replication (GO:0032201)2.69832047
123positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.69751891
124regulation of myeloid leukocyte mediated immunity (GO:0002886)2.69550720
125ceramide catabolic process (GO:0046514)2.67212901
126oligosaccharide catabolic process (GO:0009313)2.66626233
127pH reduction (GO:0045851)2.66593876
128DNA strand elongation involved in DNA replication (GO:0006271)2.66359693
129regulation of leukocyte degranulation (GO:0043300)2.65905169
130positive regulation of monocyte chemotaxis (GO:0090026)2.65838127
131antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.62774686
132macrophage activation involved in immune response (GO:0002281)2.62294280
133protein localization to kinetochore (GO:0034501)2.61940016
134regulation of translation in response to stress (GO:0043555)2.61314418
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59109247
136regulation of integrin-mediated signaling pathway (GO:2001044)2.56752263
137positive regulation of cell cycle arrest (GO:0071158)2.56035177
138endosome to pigment granule transport (GO:0043485)2.55792088
139endosome to melanosome transport (GO:0035646)2.55792088
140positive regulation of ligase activity (GO:0051351)2.53945862
141maturation of SSU-rRNA (GO:0030490)2.52569272
142granulocyte activation (GO:0036230)2.52283695
143mitotic nuclear envelope disassembly (GO:0007077)2.51783227
144DNA strand elongation (GO:0022616)2.51509419
145regulation of interferon-beta production (GO:0032648)2.49591043
146neutrophil activation (GO:0042119)2.48657807
147cellular response to interferon-alpha (GO:0035457)2.48568613
148ribonucleoprotein complex biogenesis (GO:0022613)2.47441924
149positive regulation of lymphocyte apoptotic process (GO:0070230)2.47050337
150hydrogen peroxide biosynthetic process (GO:0050665)2.46608432
151regulation of RIG-I signaling pathway (GO:0039535)2.46415820
152DNA replication initiation (GO:0006270)2.45426151
153regulation of double-strand break repair via homologous recombination (GO:0010569)2.45202512
154regulation of spindle organization (GO:0090224)2.45021927
155cyclooxygenase pathway (GO:0019371)2.43681157
156G1/S transition of mitotic cell cycle (GO:0000082)2.43445706
157cell cycle G1/S phase transition (GO:0044843)2.43445706
158blastocyst development (GO:0001824)2.40864103
159DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.40708625
160mitotic recombination (GO:0006312)2.40199614
161positive regulation of SMAD protein import into nucleus (GO:0060391)2.39621811
162production of molecular mediator involved in inflammatory response (GO:0002532)2.38188524
163respiratory burst (GO:0045730)2.37855037
164pinocytosis (GO:0006907)2.36844014
165Arp2/3 complex-mediated actin nucleation (GO:0034314)2.36640723
166regulation of integrin activation (GO:0033623)2.36410197
167lymphocyte mediated immunity (GO:0002449)2.35285517
168superoxide anion generation (GO:0042554)2.34954196
169positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.33247877
170regulation of ubiquitin-protein transferase activity (GO:0051438)2.32884455
171glycosphingolipid catabolic process (GO:0046479)2.32102543
172positive regulation of T cell apoptotic process (GO:0070234)2.31764051
173nuclear envelope disassembly (GO:0051081)2.29399888
174membrane disassembly (GO:0030397)2.29399888
175wound healing, spreading of epidermal cells (GO:0035313)2.28497469
176positive regulation of chromosome segregation (GO:0051984)2.28396726
177replication fork processing (GO:0031297)2.27288889
178ribosomal large subunit biogenesis (GO:0042273)2.26383214

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06095853
2IKZF1_21737484_ChIP-ChIP_HCT116_Human3.36865466
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.33579641
4RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.02813814
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.90051054
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.84023660
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79866378
8SCL_19346495_ChIP-Seq_HPC-7_Human2.76969703
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.72277271
10LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.71040286
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.43140863
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.43083873
13* VDR_21846776_ChIP-Seq_THP-1_Human2.41340252
14* VDR_24763502_ChIP-Seq_THP-1_Human2.35923441
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32245723
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30711464
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.29566688
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.26644237
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.22568978
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22046535
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.21675996
22SPI1_23127762_ChIP-Seq_K562_Human2.20492328
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.20438554
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.20095527
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.18494893
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.14561218
27LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.14346689
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.11755240
29MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.10983298
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.09533074
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06980541
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03849812
33VDR_24787735_ChIP-Seq_THP-1_Human2.02173714
34E2F4_17652178_ChIP-ChIP_JURKAT_Human2.00905666
35NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00825343
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.88532733
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85731169
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84185212
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78943451
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76758866
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.75970047
42VDR_23849224_ChIP-Seq_CD4+_Human1.75324593
43TFEB_21752829_ChIP-Seq_HELA_Human1.72957057
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72617940
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.71698981
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.71148960
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69577350
48KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.67575494
49KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.67575494
50KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.67575494
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67259814
52IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66911203
53* BCL6_27268052_Chip-Seq_Bcells_Human1.63836666
54LXR_22292898_ChIP-Seq_THP-1_Human1.63832406
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.62570026
56SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.61888318
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.60676832
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57765701
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.57280244
60SPI1_23547873_ChIP-Seq_NB4_Human1.55928017
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54228091
62MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53403343
63MAF_26560356_Chip-Seq_TH1_Human1.52095842
64PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.51329286
65DCP1A_22483619_ChIP-Seq_HELA_Human1.50460515
66XRN2_22483619_ChIP-Seq_HELA_Human1.49774597
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49771316
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48495979
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.48084541
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46525186
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.46451589
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45062834
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.44462568
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42682518
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41419661
76KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40732965
77SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40043713
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39988270
79GATA1_19941826_ChIP-Seq_K562_Human1.39319381
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.38328231
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38053598
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36054831
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36008338
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.35931380
85EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35780580
86SRF_21415370_ChIP-Seq_HL-1_Mouse1.35035444
87MAF_26560356_Chip-Seq_TH2_Human1.34451577
88AR_21909140_ChIP-Seq_LNCAP_Human1.34238129
89ELK1_19687146_ChIP-ChIP_HELA_Human1.33850345
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33600775
91MYB_26560356_Chip-Seq_TH2_Human1.32492511
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32402735
93GABP_19822575_ChIP-Seq_HepG2_Human1.32336110
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31794429
95BCOR_27268052_Chip-Seq_Bcells_Human1.31221140
96PU_27001747_Chip-Seq_BMDM_Mouse1.31133816
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30430189
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.29795240
99RUNX_20019798_ChIP-Seq_JUKART_Human1.29605402
100CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29588738
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29246415
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29084099
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28841175
104CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28612454
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27451851
106NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.27158330
107UTX_26944678_Chip-Seq_JUKART_Human1.21662968
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21334906
109* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21330496
110STAT1_20625510_ChIP-Seq_HELA_Human1.20755834
111Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20389401
112FOXP3_21729870_ChIP-Seq_TREG_Human1.19976294
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19027687
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16030763
115* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15234295
116GATA3_26560356_Chip-Seq_TH2_Human1.14932906
117SA1_27219007_Chip-Seq_Bcells_Human1.14516252
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14142795
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12198636
120TTF2_22483619_ChIP-Seq_HELA_Human1.12095483
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11737177
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10673867
123IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09191161
124STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08712111
125MYB_26560356_Chip-Seq_TH1_Human1.08377763
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.08254697
127E2F1_21310950_ChIP-Seq_MCF-7_Human1.07833058
128FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07668321
129KDM5A_27292631_Chip-Seq_BREAST_Human1.07577188
130* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07413921
131KDM2B_26808549_Chip-Seq_DND41_Human1.07102154
132HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.07033561
133KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06641505
134OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06061642
135BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03467983
136MYC_22102868_ChIP-Seq_BL_Human1.03297211
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.01868858
138NANOG_18692474_ChIP-Seq_MEFs_Mouse1.01201639
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01025879
140STAT4_19710469_ChIP-ChIP_TH1__Mouse1.00885355
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00671085
142E2F1_20622854_ChIP-Seq_HELA_Human1.00496291
143ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00297734
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00277918
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00161903
146PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00146123
147PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99680045
148ELK1_22589737_ChIP-Seq_MCF10A_Human0.99588629
149TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99193989
150ELK3_25401928_ChIP-Seq_HUVEC_Human0.99014300
151PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98385436
152ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98312250
153GATA1_22025678_ChIP-Seq_K562_Human0.98097315
154THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97714854
155NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97674324
156HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96848014
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96116303
158GATA3_27048872_Chip-Seq_THYMUS_Human0.96114837
159CTCF_26484167_Chip-Seq_Bcells_Mouse0.95866567
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95837752
161PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95517210
162EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.95461283
163CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94986407
164ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93024638
165CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92703022
166GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92219215
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.91119658
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90289385
169CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87315208
170P68_20966046_ChIP-Seq_HELA_Human0.86503612
171CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.85896788
172STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85311591
173SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.84550862
174RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83963561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.01297304
2MP0005058_abnormal_lysosome_morphology3.47188899
3MP0003693_abnormal_embryo_hatching3.40864797
4MP0001835_abnormal_antigen_presentation2.84478293
5MP0009840_abnormal_foam_cell2.79723760
6MP0003111_abnormal_nucleus_morphology2.57322039
7MP0005365_abnormal_bile_salt2.51592895
8MP0004957_abnormal_blastocyst_morpholog2.43962473
9MP0003436_decreased_susceptibility_to2.43189621
10MP0002148_abnormal_hypersensitivity_rea2.18618359
11MP0006082_CNS_inflammation2.17005635
12MP0005167_abnormal_blood-brain_barrier2.14836077
13MP0003077_abnormal_cell_cycle2.14644738
14MP0010352_gastrointestinal_tract_polyps2.12002015
15MP0010094_abnormal_chromosome_stability2.03375670
16MP0000604_amyloidosis2.01250161
17MP0003172_abnormal_lysosome_physiology2.01024598
18MP0009785_altered_susceptibility_to1.98162998
19MP0002419_abnormal_innate_immunity1.94647714
20MP0002254_reproductive_system_inflammat1.93600484
21MP0008057_abnormal_DNA_replication1.90754404
22MP0010307_abnormal_tumor_latency1.88636678
23MP0003186_abnormal_redox_activity1.83842979
24MP0005000_abnormal_immune_tolerance1.78454339
25MP0008260_abnormal_autophagy1.71400628
26MP0005025_abnormal_response_to1.69822031
27MP0003448_altered_tumor_morphology1.69762889
28MP0005397_hematopoietic_system_phenotyp1.68294573
29MP0001545_abnormal_hematopoietic_system1.68294573
30MP0002452_abnormal_antigen_presenting1.68201927
31MP0009278_abnormal_bone_marrow1.66605049
32MP0001853_heart_inflammation1.62564868
33MP0003300_gastrointestinal_ulcer1.62446441
34MP0003718_maternal_effect1.62221428
35MP0008007_abnormal_cellular_replicative1.60190292
36MP0003566_abnormal_cell_adhesion1.59581898
37MP0009333_abnormal_splenocyte_physiolog1.55603511
38MP0008961_abnormal_basal_metabolism1.54261051
39MP0008058_abnormal_DNA_repair1.52135930
40MP0003690_abnormal_glial_cell1.49921214
41MP0003075_altered_response_to1.49576768
42MP0003786_premature_aging1.46500921
43MP0000685_abnormal_immune_system1.45232487
44MP0002723_abnormal_immune_serum1.44343248
45MP0003191_abnormal_cellular_cholesterol1.42104574
46MP0005670_abnormal_white_adipose1.36491622
47MP0001800_abnormal_humoral_immune1.36489578
48MP0004043_abnormal_pH_regulation1.36262551
49MP0002139_abnormal_hepatobiliary_system1.36038833
50MP0008932_abnormal_embryonic_tissue1.35685126
51MP0000858_altered_metastatic_potential1.35262839
52MP0002405_respiratory_system_inflammati1.34834363
53MP0005085_abnormal_gallbladder_physiolo1.34052811
54MP0001819_abnormal_immune_cell1.33323430
55MP0003303_peritoneal_inflammation1.31742901
56MP0000343_altered_response_to1.31473715
57MP0002998_abnormal_bone_remodeling1.30335085
58MP0002420_abnormal_adaptive_immunity1.29674858
59MP0000490_abnormal_crypts_of1.28041792
60MP0005671_abnormal_response_to1.27825767
61MP0000015_abnormal_ear_pigmentation1.26882346
62MP0005387_immune_system_phenotype1.26826108
63MP0001790_abnormal_immune_system1.26826108
64MP0001533_abnormal_skeleton_physiology1.26617332
65MP0005023_abnormal_wound_healing1.25985616
66MP0002396_abnormal_hematopoietic_system1.24000632
67MP0003195_calcinosis1.23584268
68MP0004782_abnormal_surfactant_physiolog1.23177371
69MP0000371_diluted_coat_color1.22565755
70MP0003252_abnormal_bile_duct1.21617891
71MP0005451_abnormal_body_composition1.19610714
72MP0005464_abnormal_platelet_physiology1.19475621
73MP0003705_abnormal_hypodermis_morpholog1.19450841
74MP0003724_increased_susceptibility_to1.17059375
75MP0000350_abnormal_cell_proliferation1.15908702
76MP0000689_abnormal_spleen_morphology1.15426801
77MP0001845_abnormal_inflammatory_respons1.13464339
78MP0001730_embryonic_growth_arrest1.12565341
79MP0008438_abnormal_cutaneous_collagen1.11905093
80MP0001542_abnormal_bone_strength1.09753511
81MP0002722_abnormal_immune_system1.08838478
82MP0005076_abnormal_cell_differentiation1.08791818
83MP0008469_abnormal_protein_level1.06493940
84MP0000716_abnormal_immune_system1.06203420
85MP0005257_abnormal_intraocular_pressure1.03857059
86MP0000313_abnormal_cell_death1.03506661
87MP0002398_abnormal_bone_marrow1.03161293
88MP0004947_skin_inflammation1.01614524
89MP0002837_dystrophic_cardiac_calcinosis1.00538118
90MP0002429_abnormal_blood_cell1.00467053
91MP0003828_pulmonary_edema1.00037857
92MP0002138_abnormal_hepatobiliary_system0.99711243
93MP0004510_myositis0.99654320
94MP0003806_abnormal_nucleotide_metabolis0.99310295
95MP0002019_abnormal_tumor_incidence0.97815297
96MP0003183_abnormal_peptide_metabolism0.95946929
97MP0001958_emphysema0.94207614
98MP0005380_embryogenesis_phenotype0.94119196
99MP0001672_abnormal_embryogenesis/_devel0.94119196
100MP0002277_abnormal_respiratory_mucosa0.92924146
101MP0001663_abnormal_digestive_system0.92405650
102MP0003941_abnormal_skin_development0.90878982
103MP0010155_abnormal_intestine_physiology0.90258531
104MP0010329_abnormal_lipoprotein_level0.89079671
105MP0000465_gastrointestinal_hemorrhage0.88448399
106MP0002086_abnormal_extraembryonic_tissu0.88308169
107MP0005395_other_phenotype0.88198005
108MP0009115_abnormal_fat_cell0.87596783
109MP0005174_abnormal_tail_pigmentation0.87404255
110MP0000372_irregular_coat_pigmentation0.87100175
111MP0009764_decreased_sensitivity_to0.86282109
112MP0003329_amyloid_beta_deposits0.86026719
113MP0004808_abnormal_hematopoietic_stem0.85739028
114MP0002088_abnormal_embryonic_growth/wei0.85023289
115MP0003984_embryonic_growth_retardation0.84767308
116MP0005310_abnormal_salivary_gland0.84638185
117MP0000920_abnormal_myelination0.83724470
118MP0004019_abnormal_vitamin_homeostasis0.82840884
119MP0005075_abnormal_melanosome_morpholog0.81945328
120MP0003567_abnormal_fetal_cardiomyocyte0.81440072
121MP0002136_abnormal_kidney_physiology0.80329580
122MP0005390_skeleton_phenotype0.80280567
123MP0002080_prenatal_lethality0.79866188
124MP0001697_abnormal_embryo_size0.79831139
125MP0000358_abnormal_cell_content/0.79474222
126MP0009763_increased_sensitivity_to0.79294027
127MP0005621_abnormal_cell_physiology0.78090217
128MP0000627_abnormal_mammary_gland0.77659960
129MP0001756_abnormal_urination0.77483841
130MP0005166_decreased_susceptibility_to0.76631356
131MP0003453_abnormal_keratinocyte_physiol0.76025532
132MP0004381_abnormal_hair_follicle0.74068000
133MP0009765_abnormal_xenobiotic_induced0.71574977
134MP0005171_absent_coat_pigmentation0.71297224
135MP0001501_abnormal_sleep_pattern0.70664652
136MP0005334_abnormal_fat_pad0.68355530
137MP0005164_abnormal_response_to0.67427971
138MP0001873_stomach_inflammation0.65779578
139MP0002933_joint_inflammation0.65434646
140MP0002877_abnormal_melanocyte_morpholog0.65269525
141MP0003763_abnormal_thymus_physiology0.65088770
142MP0002118_abnormal_lipid_homeostasis0.64894833
143MP0002095_abnormal_skin_pigmentation0.63029939
144MP0004742_abnormal_vestibular_system0.62773908
145MP0008874_decreased_physiological_sensi0.60609544
146MP0003656_abnormal_erythrocyte_physiolo0.60259433

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)4.72838080
2Vacuolated lymphocytes (HP:0001922)4.53380801
3Abnormality of macrophages (HP:0004311)4.46536122
4Loss of speech (HP:0002371)4.26373399
5Abnormality of liposaccharide metabolism (HP:0010968)4.20751305
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.20751305
7Abnormality of glycolipid metabolism (HP:0010969)4.20751305
8Eczematoid dermatitis (HP:0000976)4.16655845
9Recurrent bacterial skin infections (HP:0005406)4.11875993
10Agnosia (HP:0010524)3.79043710
11Increased cerebral lipofuscin (HP:0011813)3.70325818
12Mutism (HP:0002300)3.68461165
13Stomatitis (HP:0010280)3.56292062
14Increased neuronal autofluorescent lipopigment (HP:0002074)3.35900145
15Poor head control (HP:0002421)3.27184002
16Breast hypoplasia (HP:0003187)3.21238669
17Abnormality of polysaccharide metabolism (HP:0011012)3.17379059
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.17379059
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.17379059
20Optic neuritis (HP:0100653)3.16109574
21Retrobulbar optic neuritis (HP:0100654)3.16109574
22Pustule (HP:0200039)3.11730539
23Recurrent gram-negative bacterial infections (HP:0005420)3.09347167
24Prolonged neonatal jaundice (HP:0006579)3.07248712
25Spinal muscular atrophy (HP:0007269)3.07222047
26Autoimmune thrombocytopenia (HP:0001973)3.05443467
27Abnormality of the prostate (HP:0008775)3.01165407
28Multiple enchondromatosis (HP:0005701)2.98599731
29Birth length less than 3rd percentile (HP:0003561)2.97502523
30Pulmonary infiltrates (HP:0002113)2.95302159
31Carpal bone hypoplasia (HP:0001498)2.90002873
32Hemoptysis (HP:0002105)2.89156632
33Inappropriate behavior (HP:0000719)2.87190518
34Degeneration of anterior horn cells (HP:0002398)2.86770247
35Abnormality of the anterior horn cell (HP:0006802)2.86770247
36Personality changes (HP:0000751)2.82307381
37Rough bone trabeculation (HP:0100670)2.77689775
38Retinal atrophy (HP:0001105)2.75690815
39Meningitis (HP:0001287)2.72076546
40Purpura (HP:0000979)2.64914475
41Systemic lupus erythematosus (HP:0002725)2.64757354
42Obstructive lung disease (HP:0006536)2.63645116
43Chronic obstructive pulmonary disease (HP:0006510)2.63645116
44Petechiae (HP:0000967)2.61460461
45Mediastinal lymphadenopathy (HP:0100721)2.60323794
46Axonal loss (HP:0003447)2.58289065
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.54945182
48Osteolytic defects of the hand bones (HP:0009699)2.54945182
49Vertebral compression fractures (HP:0002953)2.54022360
50Hematochezia (HP:0002573)2.53649772
51Tongue fasciculations (HP:0001308)2.51892909
52Dysostosis multiplex (HP:0000943)2.51591437
53Spontaneous hematomas (HP:0007420)2.51193534
54Nausea (HP:0002018)2.50466500
55Basal ganglia calcification (HP:0002135)2.49323551
56Glomerulonephritis (HP:0000099)2.47588948
57Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.46166846
58Neurofibrillary tangles (HP:0002185)2.45690601
59Polyneuropathy (HP:0001271)2.44323492
60Hepatosplenomegaly (HP:0001433)2.38761240
61Chest pain (HP:0100749)2.36938907
62Gingivitis (HP:0000230)2.36937730
63Abnormality of the umbilical cord (HP:0010881)2.35921915
64Vasculitis (HP:0002633)2.34762645
65Recurrent cutaneous fungal infections (HP:0011370)2.34566399
66Chronic mucocutaneous candidiasis (HP:0002728)2.34566399
67Abnormal trabecular bone morphology (HP:0100671)2.34212660
68Interstitial pulmonary disease (HP:0006530)2.33763442
69Nuclear cataract (HP:0100018)2.32004953
70Increased IgM level (HP:0003496)2.30010113
71Mesangial abnormality (HP:0001966)2.29966413
72Prostate neoplasm (HP:0100787)2.26500691
73Muscle fibrillation (HP:0010546)2.26384254
74Progressive neurologic deterioration (HP:0002344)2.24224590
75Recurrent fungal infections (HP:0002841)2.22428501
76Global brain atrophy (HP:0002283)2.21578268
77Cheilitis (HP:0100825)2.21155901
78Pulmonary embolism (HP:0002204)2.19495137
79Elevated erythrocyte sedimentation rate (HP:0003565)2.19338805
80Urticaria (HP:0001025)2.19226872
81Abnormality of the distal phalanges of the toes (HP:0010182)2.18865426
82Encephalitis (HP:0002383)2.15825820
83Recurrent skin infections (HP:0001581)2.15163394
84Reticulocytopenia (HP:0001896)2.14363236
85Increased serum ferritin (HP:0003281)2.14297938
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.13388387
87Gangrene (HP:0100758)2.12635471
88Cervical subluxation (HP:0003308)2.11444494
89Diminished motivation (HP:0000745)2.11287724
90Disinhibition (HP:0000734)2.09682821
91Amyloidosis (HP:0011034)2.08580595
92Upper motor neuron abnormality (HP:0002127)2.08535998
93Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07575490
94Trismus (HP:0000211)2.05982436
95Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05033905
96Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.04696980
97Pathologic fracture (HP:0002756)2.03947078
98Abnormality of the pleura (HP:0002103)2.03838527
99Restrictive lung disease (HP:0002091)2.02057158
100Patellar aplasia (HP:0006443)1.99882654
101Fused cervical vertebrae (HP:0002949)1.97774700
102Apathy (HP:0000741)1.97217992
103Absent radius (HP:0003974)1.97127191
104Cutaneous photosensitivity (HP:0000992)1.96283136
105Keratoconjunctivitis sicca (HP:0001097)1.96245062
106Sparse eyelashes (HP:0000653)1.96202513
107Neuronal loss in central nervous system (HP:0002529)1.95868444
108Bone marrow hypocellularity (HP:0005528)1.94396242
109Aplasia/Hypoplasia of the patella (HP:0006498)1.91633665
110Tetraparesis (HP:0002273)1.91449949
111Keratoconjunctivitis (HP:0001096)1.91392024
112Clumsiness (HP:0002312)1.91219910
113Pulmonary fibrosis (HP:0002206)1.91182076
114Chromsome breakage (HP:0040012)1.90963391
115Complement deficiency (HP:0004431)1.90768079
116Aplasia/hypoplasia of the humerus (HP:0006507)1.90748456
117Cleft eyelid (HP:0000625)1.90506046
118Granulocytopenia (HP:0001913)1.90369860
119Premature loss of primary teeth (HP:0006323)1.89509036
120Epistaxis (HP:0000421)1.88907386
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88869240
122Porencephaly (HP:0002132)1.88487934
123Premature rupture of membranes (HP:0001788)1.88407173
124Tubulointerstitial fibrosis (HP:0005576)1.86963686
125Meckel diverticulum (HP:0002245)1.86238670
126Ocular albinism (HP:0001107)1.85028031
127Ureteral duplication (HP:0000073)1.84890554
128Anorexia (HP:0002039)1.84007261
129Urinary glycosaminoglycan excretion (HP:0003541)1.83910682
130Mucopolysacchariduria (HP:0008155)1.83910682
131Dementia (HP:0000726)1.83560399
132Bilateral sensorineural hearing impairment (HP:0008619)1.83411635
133Abnormality of iron homeostasis (HP:0011031)1.83165405
134Episodic fever (HP:0001954)1.83135991
135Myositis (HP:0100614)1.82335358
136Selective tooth agenesis (HP:0001592)1.81410125
137Abnormality of the ileum (HP:0001549)1.80436006
138Premature ovarian failure (HP:0008209)1.79880034
139Albinism (HP:0001022)1.79666312
140Increased CSF protein (HP:0002922)1.78849003
141Aplasia involving forearm bones (HP:0009822)1.76036374
142Absent forearm bone (HP:0003953)1.76036374
143Myocardial infarction (HP:0001658)1.75031285
144Arterial thrombosis (HP:0004420)1.74851754
145Leukocytosis (HP:0001974)1.74658301
146Eosinophilia (HP:0001880)1.73893163
147Hypokinesia (HP:0002375)1.73581644
148Rectovaginal fistula (HP:0000143)1.73016484
149Rectal fistula (HP:0100590)1.73016484
150Peripheral demyelination (HP:0011096)1.72466450
151Psychosis (HP:0000709)1.70991140
152Orchitis (HP:0100796)1.70904368
153Leukopenia (HP:0001882)1.70645005
154Absent hand (HP:0004050)1.70447485
155Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70404994
156Patent foramen ovale (HP:0001655)1.68702676
157Periodontitis (HP:0000704)1.68623580
158Aplasia/Hypoplasia of the sacrum (HP:0008517)1.68335955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CCNB14.72929053
2CAMKK24.24536260
3BUB13.96972783
4WEE13.93225271
5CAMK1D3.57333234
6EPHA23.52019984
7IRAK33.24601898
8PIM22.73405333
9PBK2.57211544
10NME22.47369077
11BLK2.18882227
12TXK2.13679496
13EIF2AK12.12799129
14PLK42.11766776
15CAMK1G2.07706825
16ZAK1.95866597
17IKBKB1.92831751
18MAP3K141.82747033
19TBK11.82469414
20IRAK41.78243857
21GRK71.60270296
22NEK21.59365825
23FGR1.58148394
24TYK21.58043379
25FES1.57316199
26CAMKK11.56226771
27SYK1.55874503
28AKT31.52602040
29TSSK61.51553860
30PIM11.50120406
31NEK11.49318895
32TTK1.46461813
33TNK21.45561217
34ADRBK21.45003717
35SMG11.40563182
36MST1R1.36134502
37SRPK11.34699531
38EIF2AK31.33342786
39RPS6KA41.32546381
40STK41.29458025
41ABL21.29239087
42ARAF1.28959973
43MAP3K111.28916131
44PAK41.27318872
45TAF11.27274735
46PLK11.26788858
47PRPF4B1.18478551
48TAOK21.16572972
49TESK21.12863503
50MAP3K31.11675822
51KIT1.10375409
52STK101.09824648
53TAOK11.08421340
54STK31.05759306
55PDK21.05355286
56CDK71.05081941
57VRK21.04698092
58CHUK1.04398360
59MAP3K81.04215145
60RPS6KB21.03912473
61EIF2AK21.03107550
62RIPK41.02620154
63ACVR1B1.02572120
64BRSK21.01203575
65NEK91.01167361
66STK160.94037650
67MATK0.92923132
68CDK120.91925295
69DAPK20.91628733
70MAP4K10.88979016
71BMX0.87231534
72MARK20.83723536
73ERN10.83463542
74BTK0.82459455
75IKBKE0.80520059
76KDR0.80438164
77MAP3K70.79966202
78MST40.79540734
79AURKB0.79439925
80LCK0.79217363
81ATR0.78858067
82ZAP700.76936897
83MAP2K30.76804064
84STK240.75338138
85DYRK30.75240244
86CAMK10.74988694
87PAK10.74792356
88WNK40.74566790
89TGFBR20.73838943
90PLK30.73133886
91TAOK30.73112466
92CHEK20.70477450
93AURKA0.68291526
94TESK10.67774891
95JAK30.67526299
96CSF1R0.66792501
97LRRK20.66502397
98CDK40.66092829
99HIPK20.65674592
100CDC42BPA0.64907511
101VRK10.64768652
102ALK0.63395423
103CDC70.61104066
104CSK0.60997470
105MAPK40.60974103
106TGFBR10.57698246
107LYN0.57196412
108MET0.56455887
109MAP2K60.56263369
110JAK20.55176796
111ITK0.53652984
112DDR20.52358970
113CSNK2A10.51190654
114MARK30.51078308
115PRKCD0.50546706
116MKNK10.49587547
117CAMK40.49327396
118HCK0.48290945
119TRPM70.48198260
120TLK10.48156906
121STK38L0.48068521
122MAP3K50.47537199
123MAP3K10.46937753
124CDK60.45835525
125GRK60.45559825
126PRKCI0.44074703
127PRKAA20.43604872
128RPS6KA50.43179942
129YES10.42756018
130BRAF0.41150990
131MOS0.40887803
132TEC0.40729354
133CHEK10.39360748
134RPS6KA60.38567928
135JAK10.37911403
136ABL10.37321746
137DYRK1B0.37103081
138ERBB30.36365228
139PNCK0.35729872
140NUAK10.35671046
141MAP3K130.35435681
142IRAK20.35095058
143RPS6KL10.34667628
144RPS6KC10.34667628
145CSNK1G30.34104091
146PDPK10.33771794
147SIK20.29062512
148PDK10.28895011
149IRAK10.28704239
150CSNK1G20.27022345
151PRKCQ0.26746796
152BCKDK0.26157645
153PRKD20.25912825
154GRK10.24383424
155GRK50.23205786
156PKN10.22870604
157FYN0.21056696
158MAPK120.20930889

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.98266447
2DNA replication_Homo sapiens_hsa030302.84570030
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68771132
4Mismatch repair_Homo sapiens_hsa034302.42140230
5RNA polymerase_Homo sapiens_hsa030202.40784372
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.40567244
7Lysosome_Homo sapiens_hsa041422.22829739
8Base excision repair_Homo sapiens_hsa034102.08759527
9Ribosome_Homo sapiens_hsa030102.02069164
10Other glycan degradation_Homo sapiens_hsa005111.98087602
11RNA transport_Homo sapiens_hsa030131.93141463
12* Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89667573
13Homologous recombination_Homo sapiens_hsa034401.89662983
14Legionellosis_Homo sapiens_hsa051341.79575139
15Pyrimidine metabolism_Homo sapiens_hsa002401.68299239
16Spliceosome_Homo sapiens_hsa030401.60907053
17Leishmaniasis_Homo sapiens_hsa051401.60738661
18Nucleotide excision repair_Homo sapiens_hsa034201.60107749
19One carbon pool by folate_Homo sapiens_hsa006701.59018733
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.57938182
21Antigen processing and presentation_Homo sapiens_hsa046121.49141958
22p53 signaling pathway_Homo sapiens_hsa041151.48972292
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.47653778
24Vitamin B6 metabolism_Homo sapiens_hsa007501.45527603
25Cell cycle_Homo sapiens_hsa041101.40571156
26Graft-versus-host disease_Homo sapiens_hsa053321.39560428
27Staphylococcus aureus infection_Homo sapiens_hsa051501.36018994
28Epstein-Barr virus infection_Homo sapiens_hsa051691.33234482
29Rheumatoid arthritis_Homo sapiens_hsa053231.30199728
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.27610835
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25642593
32Fructose and mannose metabolism_Homo sapiens_hsa000511.25377554
33Pentose phosphate pathway_Homo sapiens_hsa000301.23651048
34Allograft rejection_Homo sapiens_hsa053301.23137497
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22467687
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21724043
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.20640111
38Herpes simplex infection_Homo sapiens_hsa051681.18501695
39Fanconi anemia pathway_Homo sapiens_hsa034601.17956388
40Measles_Homo sapiens_hsa051621.16339905
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16291009
42Apoptosis_Homo sapiens_hsa042101.16229410
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14725925
44Regulation of autophagy_Homo sapiens_hsa041401.13037526
45Phagosome_Homo sapiens_hsa041451.12201353
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09998288
47Folate biosynthesis_Homo sapiens_hsa007901.09267713
48Tuberculosis_Homo sapiens_hsa051521.08627489
49Shigellosis_Homo sapiens_hsa051311.06726451
50Malaria_Homo sapiens_hsa051441.04798400
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.02379975
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00373225
53Chemokine signaling pathway_Homo sapiens_hsa040620.99004717
54Influenza A_Homo sapiens_hsa051640.98055598
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97237487
56Pertussis_Homo sapiens_hsa051330.97071792
57Asthma_Homo sapiens_hsa053100.92115224
58Osteoclast differentiation_Homo sapiens_hsa043800.92103118
59T cell receptor signaling pathway_Homo sapiens_hsa046600.91007026
60Galactose metabolism_Homo sapiens_hsa000520.89964176
61Glutathione metabolism_Homo sapiens_hsa004800.87099770
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85215314
63Basal transcription factors_Homo sapiens_hsa030220.84913800
64Synaptic vesicle cycle_Homo sapiens_hsa047210.84643409
65African trypanosomiasis_Homo sapiens_hsa051430.81541567
66Vibrio cholerae infection_Homo sapiens_hsa051100.77744427
67Renin-angiotensin system_Homo sapiens_hsa046140.75751760
68Arachidonic acid metabolism_Homo sapiens_hsa005900.74174227
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73571120
70Viral carcinogenesis_Homo sapiens_hsa052030.73231664
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72991776
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72746686
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72300547
74Salmonella infection_Homo sapiens_hsa051320.71663221
75Acute myeloid leukemia_Homo sapiens_hsa052210.70499331
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70419939
77Ether lipid metabolism_Homo sapiens_hsa005650.69516658
78Collecting duct acid secretion_Homo sapiens_hsa049660.67331825
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.66259465
80Non-homologous end-joining_Homo sapiens_hsa034500.66130095
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65804228
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65520212
83Purine metabolism_Homo sapiens_hsa002300.64818944
84TNF signaling pathway_Homo sapiens_hsa046680.64287666
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63077302
86Toxoplasmosis_Homo sapiens_hsa051450.63019306
87Complement and coagulation cascades_Homo sapiens_hsa046100.59648329
88Hematopoietic cell lineage_Homo sapiens_hsa046400.59273128
89RNA degradation_Homo sapiens_hsa030180.58501550
90Tryptophan metabolism_Homo sapiens_hsa003800.55245258
91Small cell lung cancer_Homo sapiens_hsa052220.53273730
92Autoimmune thyroid disease_Homo sapiens_hsa053200.52987196
93Adipocytokine signaling pathway_Homo sapiens_hsa049200.52501606
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51990125
95Sphingolipid metabolism_Homo sapiens_hsa006000.51869438
96HIF-1 signaling pathway_Homo sapiens_hsa040660.51457996
97Prion diseases_Homo sapiens_hsa050200.50495939
98Hepatitis B_Homo sapiens_hsa051610.50199004
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50157521
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49441728
101Caffeine metabolism_Homo sapiens_hsa002320.48277849
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.47030575
103B cell receptor signaling pathway_Homo sapiens_hsa046620.46858233
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46832641
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.45665388
106HTLV-I infection_Homo sapiens_hsa051660.45537927
107Mineral absorption_Homo sapiens_hsa049780.45420677
108Biosynthesis of amino acids_Homo sapiens_hsa012300.44558343
109Viral myocarditis_Homo sapiens_hsa054160.44543353
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41789164
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.40978619
112Platelet activation_Homo sapiens_hsa046110.40587355
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40215328
114Type I diabetes mellitus_Homo sapiens_hsa049400.39543672
115Vitamin digestion and absorption_Homo sapiens_hsa049770.39536311
116Amoebiasis_Homo sapiens_hsa051460.39451980
117Bladder cancer_Homo sapiens_hsa052190.39327006
118Hepatitis C_Homo sapiens_hsa051600.36563594
119Oxidative phosphorylation_Homo sapiens_hsa001900.36325627
120Systemic lupus erythematosus_Homo sapiens_hsa053220.35974681
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35309579
122Sulfur metabolism_Homo sapiens_hsa009200.34788330
123Phototransduction_Homo sapiens_hsa047440.34521566
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34030441
125Primary immunodeficiency_Homo sapiens_hsa053400.32947098
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.32361392
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30599870
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29618450
129PPAR signaling pathway_Homo sapiens_hsa033200.29590323
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28368391
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.26460655
132Linoleic acid metabolism_Homo sapiens_hsa005910.25061270
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24519701
134Glycerolipid metabolism_Homo sapiens_hsa005610.20729288
135Endocytosis_Homo sapiens_hsa041440.19080839
136Ovarian steroidogenesis_Homo sapiens_hsa049130.18909966
137Prolactin signaling pathway_Homo sapiens_hsa049170.17453036
138Histidine metabolism_Homo sapiens_hsa003400.15907962
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15608713
140Primary bile acid biosynthesis_Homo sapiens_hsa001200.15545344

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