REP15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this intronless gene interacts with GTP-bound Rab15 and is involved in recycling of transferrin receptor from the endocytic recycling compartment to the cell surface. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.09095963
2angiotensin maturation (GO:0002003)6.11089646
3regulation of guanylate cyclase activity (GO:0031282)5.86443754
4intestinal absorption (GO:0050892)5.46878606
5regulation of systemic arterial blood pressure by hormone (GO:0001990)4.88204335
6regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.88204335
7endocrine process (GO:0050886)4.88204335
83-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.85672564
9purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.85672564
10positive regulation of guanylate cyclase activity (GO:0031284)4.66947947
11telomere maintenance via semi-conservative replication (GO:0032201)4.60141963
12sperm capacitation (GO:0048240)4.57101797
13DNA deamination (GO:0045006)4.56301710
14regulation of nuclear cell cycle DNA replication (GO:0033262)4.54195078
15negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.50775432
16sulfation (GO:0051923)4.43983546
17acrosome reaction (GO:0007340)4.32922756
18cellular glucuronidation (GO:0052695)4.32634738
19telomere maintenance via recombination (GO:0000722)4.28178468
20renal system process involved in regulation of blood volume (GO:0001977)4.24557344
21DNA replication checkpoint (GO:0000076)4.23166637
22glucuronate metabolic process (GO:0019585)4.19355808
23uronic acid metabolic process (GO:0006063)4.19355808
24oligosaccharide biosynthetic process (GO:0009312)4.16717711
25regulation of systemic arterial blood pressure (GO:0003073)4.04733476
26digestion (GO:0007586)4.02196332
27receptor guanylyl cyclase signaling pathway (GO:0007168)4.00370962
28proteasome assembly (GO:0043248)4.00301446
29DNA strand elongation involved in DNA replication (GO:0006271)3.96686147
30phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.93746535
31rRNA modification (GO:0000154)3.90866698
32DNA strand elongation (GO:0022616)3.88674693
33ribosome assembly (GO:0042255)3.85216771
34mitotic recombination (GO:0006312)3.84229691
35telomere maintenance via telomere lengthening (GO:0010833)3.82873952
36DNA replication initiation (GO:0006270)3.81449067
37positive regulation of respiratory burst (GO:0060267)3.79796144
38CENP-A containing nucleosome assembly (GO:0034080)3.74658495
39protein K6-linked ubiquitination (GO:0085020)3.71553089
40chromatin remodeling at centromere (GO:0031055)3.70394296
41regulation of bile acid biosynthetic process (GO:0070857)3.68851667
42ribosome biogenesis (GO:0042254)3.68843501
43epoxygenase P450 pathway (GO:0019373)3.65547072
44termination of RNA polymerase III transcription (GO:0006386)3.65172506
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.65172506
46sulfate transmembrane transport (GO:1902358)3.63981708
47regulation of double-strand break repair via homologous recombination (GO:0010569)3.63850204
48fusion of sperm to egg plasma membrane (GO:0007342)3.62143810
49regulation of cGMP biosynthetic process (GO:0030826)3.62123836
50purine nucleobase biosynthetic process (GO:0009113)3.61283971
51fructose metabolic process (GO:0006000)3.60712957
52fat-soluble vitamin biosynthetic process (GO:0042362)3.58280834
53diacylglycerol metabolic process (GO:0046339)3.56498270
54sexual reproduction (GO:0019953)3.55275650
557-methylguanosine mRNA capping (GO:0006370)3.54479106
56DNA double-strand break processing (GO:0000729)3.51750522
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.51221507
58RNA capping (GO:0036260)3.50185737
597-methylguanosine RNA capping (GO:0009452)3.50185737
60cellular response to pH (GO:0071467)3.50031729
61deoxyribonucleotide biosynthetic process (GO:0009263)3.49776312
62maturation of 5.8S rRNA (GO:0000460)3.48931093
63transcytosis (GO:0045056)3.44026159
64DNA-dependent DNA replication (GO:0006261)3.42062738
65hormone catabolic process (GO:0042447)3.41765590
66nucleobase biosynthetic process (GO:0046112)3.41377469
67regulation of cellular extravasation (GO:0002691)3.40391554
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.39118454
69kinetochore assembly (GO:0051382)3.38711049
70renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.36639366
71coenzyme catabolic process (GO:0009109)3.34640852
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33240811
73deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.32779884
74transcription from RNA polymerase I promoter (GO:0006360)3.32481567
75transcription-coupled nucleotide-excision repair (GO:0006283)3.32098765
76bile acid and bile salt transport (GO:0015721)3.30705030
77GTP biosynthetic process (GO:0006183)3.30354633
78termination of RNA polymerase I transcription (GO:0006363)3.28239860
79lipoprotein transport (GO:0042953)3.26371023
80NADH metabolic process (GO:0006734)3.25939440
81meiotic chromosome segregation (GO:0045132)3.25698717
82regulation of cGMP metabolic process (GO:0030823)3.25281088
83nucleotide-sugar biosynthetic process (GO:0009226)3.24941845
84nucleoside diphosphate biosynthetic process (GO:0009133)3.24860086
85negative regulation of DNA-dependent DNA replication (GO:2000104)3.24143726
86ribosomal small subunit assembly (GO:0000028)3.22971705
87rRNA methylation (GO:0031167)3.21655950
88glucocorticoid biosynthetic process (GO:0006704)3.20657007
89drug transmembrane transport (GO:0006855)3.20464664
90mitotic metaphase plate congression (GO:0007080)3.20248289
91kinetochore organization (GO:0051383)3.20196712
92response to acidic pH (GO:0010447)3.19714967
93DNA catabolic process, exonucleolytic (GO:0000738)3.19695575
94sperm motility (GO:0030317)3.19510887
95deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.19466416
96tRNA methylation (GO:0030488)3.17579846
97cGMP biosynthetic process (GO:0006182)3.16888013
98left/right pattern formation (GO:0060972)3.13003027
99cGMP-mediated signaling (GO:0019934)3.11538060
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11364137
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11364137
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11364137
103DNA synthesis involved in DNA repair (GO:0000731)3.09754191
104ribonucleoprotein complex biogenesis (GO:0022613)3.09560320
105intestinal epithelial cell development (GO:0060576)3.08820994
106RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.07832068
107tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.07832068
108very-low-density lipoprotein particle assembly (GO:0034379)3.07787837
109natural killer cell activation involved in immune response (GO:0002323)3.06151861
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04900492
111RNA-dependent DNA replication (GO:0006278)3.04315945
112epithelial cilium movement (GO:0003351)3.03856023
113positive regulation of pseudopodium assembly (GO:0031274)3.03776015
114adhesion of symbiont to host cell (GO:0044650)3.03760783
115virion attachment to host cell (GO:0019062)3.03760783
116nucleotide-excision repair, DNA gap filling (GO:0006297)3.03156676
117transcription elongation from RNA polymerase I promoter (GO:0006362)3.01577318
118O-glycan processing (GO:0016266)3.00983512
119negative regulation of epidermal cell differentiation (GO:0045605)3.00812272
120regulation of centriole replication (GO:0046599)3.00762728
121signal transduction involved in cell cycle checkpoint (GO:0072395)3.00196503
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00107386
123telomere maintenance (GO:0000723)2.99845650
124cellular response to zinc ion (GO:0071294)2.99684726
125positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99675206
126mitochondrial DNA replication (GO:0006264)2.99621489
127negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.99359187
128telomere organization (GO:0032200)2.99280094
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.98813571
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98813571
131IMP biosynthetic process (GO:0006188)2.98257791
132GDP-mannose metabolic process (GO:0019673)2.97451407
133sulfate transport (GO:0008272)2.97276026
134antibacterial humoral response (GO:0019731)2.96774745
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.95537488
136deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.95186671
137transcription initiation from RNA polymerase I promoter (GO:0006361)2.93655884
138regulation of vitamin metabolic process (GO:0030656)2.93507809
139labyrinthine layer development (GO:0060711)2.93284399
140flavonoid metabolic process (GO:0009812)2.92890162
141nucleobase-containing small molecule interconversion (GO:0015949)2.92697616
142phosphatidylethanolamine biosynthetic process (GO:0006646)2.91544510
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91460849
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91460849
145DNA replication-independent nucleosome organization (GO:0034724)2.90940153
146DNA replication-independent nucleosome assembly (GO:0006336)2.90940153
147anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90283050
148positive regulation of glycoprotein metabolic process (GO:1903020)2.89679321
149regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.89269742
150regulation of mitotic spindle checkpoint (GO:1903504)2.89269742
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.89186140
152replicative senescence (GO:0090399)2.88864705
153sequestering of extracellular ligand from receptor (GO:0035581)2.88599243
154reproduction (GO:0000003)2.88113144
155spliceosomal snRNP assembly (GO:0000387)2.86675458
156drug transport (GO:0015893)2.86592555
157histone exchange (GO:0043486)2.85617671
158positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.83374996
159negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.83309787
160icosanoid secretion (GO:0032309)2.82853043
161arachidonic acid secretion (GO:0050482)2.82853043
162exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81683783
163regulation of keratinocyte differentiation (GO:0045616)2.80247507
164multicellular organism reproduction (GO:0032504)2.80203728
165ethanol oxidation (GO:0006069)2.80158143
166positive regulation of glycoprotein biosynthetic process (GO:0010560)2.79638227
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.77689765
168plasma membrane fusion (GO:0045026)2.77551718
169antimicrobial humoral response (GO:0019730)2.77418945
170pseudouridine synthesis (GO:0001522)2.76870764
171ribosomal large subunit biogenesis (GO:0042273)2.76713791
172regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.76702835
173drug metabolic process (GO:0017144)2.76664704
174DNA replication (GO:0006260)2.76659783
175positive regulation of cGMP biosynthetic process (GO:0030828)2.76636403
176regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76248007
177UTP biosynthetic process (GO:0006228)2.75931142
178RNA methylation (GO:0001510)2.75440743
179cullin deneddylation (GO:0010388)2.73520020
180cell cycle G1/S phase transition (GO:0044843)2.72074361
181G1/S transition of mitotic cell cycle (GO:0000082)2.72074361
182UTP metabolic process (GO:0046051)2.70865405
183sulfur compound transport (GO:0072348)2.69892823
184regulation of cellular amino acid metabolic process (GO:0006521)2.69230541
185regulation of pseudopodium assembly (GO:0031272)2.69036716
186metaphase plate congression (GO:0051310)2.68778386
187regulation of mitochondrial translation (GO:0070129)2.67948856
188negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.67707290
189negative regulation of ligase activity (GO:0051352)2.67707290
190maturation of SSU-rRNA (GO:0030490)2.67532168
191reciprocal DNA recombination (GO:0035825)2.67501503
192reciprocal meiotic recombination (GO:0007131)2.67501503
193bile acid metabolic process (GO:0008206)2.67187216
194establishment of chromosome localization (GO:0051303)2.66857860
195plasma lipoprotein particle assembly (GO:0034377)2.66834682
196phosphatidylethanolamine metabolic process (GO:0046337)2.66116529
197cellular response to cadmium ion (GO:0071276)2.65602656
198regulation of cholesterol esterification (GO:0010872)2.65425895
199icosanoid transport (GO:0071715)2.65351860

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34104913
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.62082231
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25199721
4CDX2_20551321_ChIP-Seq_CACO-2_Human4.17786199
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.73098654
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.58170620
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.45817100
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.32827941
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28236619
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.98006962
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83169046
12GATA4_25053715_ChIP-Seq_YYC3_Human2.82453401
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.81538019
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78629141
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72659385
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.71206942
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.59626298
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57865042
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54896730
20MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49086941
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46104179
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.44057343
23VDR_23849224_ChIP-Seq_CD4+_Human2.42530607
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.42507027
25SOX2_27498859_Chip-Seq_STOMACH_Mouse2.34692112
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33783041
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.32012619
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.29963631
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.27444278
30ELK1_19687146_ChIP-ChIP_HELA_Human2.27087721
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.24410732
32GATA6_25053715_ChIP-Seq_YYC3_Human2.22035460
33SRF_21415370_ChIP-Seq_HL-1_Mouse2.21589042
34SOX2_20726797_ChIP-Seq_SW620_Human2.19320581
35FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.17465490
36FOXM1_23109430_ChIP-Seq_U2OS_Human2.10362757
37YY1_21170310_ChIP-Seq_MESCs_Mouse2.09022185
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08594122
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.98817761
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.98328511
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.97242687
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.97019691
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96073060
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95422054
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94706772
46FOXP3_21729870_ChIP-Seq_TREG_Human1.92336653
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.90027270
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89185838
49DCP1A_22483619_ChIP-Seq_HELA_Human1.86829076
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.85992194
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85535975
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.81702965
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.80627868
54XRN2_22483619_ChIP-Seq_HELA_Human1.79811993
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79808501
56CDX2_22108803_ChIP-Seq_LS180_Human1.78733014
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78220438
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.75678179
59POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.74483470
60NANOG_20526341_ChIP-Seq_ESCs_Human1.72505952
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68676612
62CJUN_26792858_Chip-Seq_BT549_Human1.68579414
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67167367
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63729757
65GABP_19822575_ChIP-Seq_HepG2_Human1.63508120
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63147988
67VDR_22108803_ChIP-Seq_LS180_Human1.60784953
68TTF2_22483619_ChIP-Seq_HELA_Human1.60453035
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58076587
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56368024
71LXR_22158963_ChIP-Seq_LIVER_Mouse1.54049420
72E2F1_21310950_ChIP-Seq_MCF-7_Human1.53605631
73KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.53456078
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53148277
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52196586
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.52042104
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50485670
78FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49586303
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.48203256
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48157925
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47938957
82IRF8_21731497_ChIP-ChIP_J774_Mouse1.41905186
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40459756
84ZNF263_19887448_ChIP-Seq_K562_Human1.40263520
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.38852186
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.37899513
87HNFA_21074721_ChIP-Seq_CACO-2_Human1.37610377
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.37379049
89FOXM1_26456572_ChIP-Seq_MCF-7_Human1.36555597
90TP63_17297297_ChIP-ChIP_HaCaT_Human1.36436179
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36293660
92AR_21909140_ChIP-Seq_LNCAP_Human1.34996618
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.34045872
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30852419
95CBP_21632823_ChIP-Seq_H3396_Human1.30331428
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29920307
97TBL1_22424771_ChIP-Seq_293T_Human1.29188443
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.26284065
99KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25774870
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25774870
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25774870
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25430746
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24389644
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23585271
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.23496782
106ARNT_22903824_ChIP-Seq_MCF-7_Human1.23399410
107AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23231046
108SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22526480
109BP1_19119308_ChIP-ChIP_Hs578T_Human1.22168659
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22087464
111FUS_26573619_Chip-Seq_HEK293_Human1.20839207
112ER_23166858_ChIP-Seq_MCF-7_Human1.20636388
113RBPJ_21746931_ChIP-Seq_IB4_Human1.20163171
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.19713176
115FOXA1_25552417_ChIP-Seq_VCAP_Human1.19444360
116PPARA_22158963_ChIP-Seq_LIVER_Mouse1.18744485
117AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18042780
118MYC_19829295_ChIP-Seq_ESCs_Human1.17376191
119FLI1_27457419_Chip-Seq_LIVER_Mouse1.16999098
120PHF8_20622853_ChIP-Seq_HELA_Human1.15597568
121SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15367191
122PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14789932
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13981787
124NFYA_21822215_ChIP-Seq_K562_Human1.13813584
125TP53_18474530_ChIP-ChIP_U2OS_Human1.12817782
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12747416
127ETV1_20927104_ChIP-Seq_GIST48_Human1.12702501
128GATA3_24758297_ChIP-Seq_MCF-7_Human1.11877698
129ERA_21632823_ChIP-Seq_H3396_Human1.11342207
130ESR1_20079471_ChIP-ChIP_T-47D_Human1.11308942
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11293107
132PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.11245415
133CTCF_27219007_Chip-Seq_Bcells_Human1.10136316
134ELK1_22589737_ChIP-Seq_MCF10A_Human1.09716891
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09693027
136NFYB_21822215_ChIP-Seq_K562_Human1.09087574
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09049498
138AHR_22903824_ChIP-Seq_MCF-7_Human1.08210977
139ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07142006
140CIITA_25753668_ChIP-Seq_RAJI_Human1.06186988
141BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05775574
142RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04447000
143KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03895299
144AR_25329375_ChIP-Seq_VCAP_Human1.03577201
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03206776
146NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03078223
147MYC_18940864_ChIP-ChIP_HL60_Human1.02959843
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02166458
149SMAD3_21741376_ChIP-Seq_HESCs_Human1.02006333
150SMAD3_21741376_ChIP-Seq_EPCs_Human1.01755100
151SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01567026
152KLF5_25053715_ChIP-Seq_YYC3_Human1.01356465
153TP63_23658742_ChIP-Seq_EP156T_Human1.01133863
154CSB_26484114_Chip-Seq_FIBROBLAST_Human1.00211625
155* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99074816
156ZNF274_21170338_ChIP-Seq_K562_Hela0.98863357
157STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98588791
158RAC3_21632823_ChIP-Seq_H3396_Human0.98526189
159P300_19829295_ChIP-Seq_ESCs_Human0.98226276
160EP300_21415370_ChIP-Seq_HL-1_Mouse0.98191016
161VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98023878
162HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96942321
163PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96796276
164SPI1_23547873_ChIP-Seq_NB4_Human0.94910430
165GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94709176
166UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94045128
167KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93905357
168RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93582983
169* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92193990
170* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91909294
171JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91806899
172PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91768099
173CEBPB_22108803_ChIP-Seq_LS180_Human0.90812827
174ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89797171
175ESR2_21235772_ChIP-Seq_MCF-7_Human0.89649416
176CBX2_22325352_ChIP-Seq_293T-Rex_Human0.89362806
177GATA6_21074721_ChIP-Seq_CACO-2_Human0.89244102
178RXR_22108803_ChIP-Seq_LS180_Human0.88968217
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.88924207
180SOX17_20123909_ChIP-Seq_XEN_Mouse0.88917046
181IRF1_19129219_ChIP-ChIP_H3396_Human0.88509380
182IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88411192
183CBP_20019798_ChIP-Seq_JUKART_Human0.88411192
184KDM5A_27292631_Chip-Seq_BREAST_Human0.87127447
185NFE2_27457419_Chip-Seq_LIVER_Mouse0.86586263
186NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.86524544
187SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81663309
188GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79334337
189POU5F1_16153702_ChIP-ChIP_HESCs_Human0.79305298
190SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79222787
191IRF8_22096565_ChIP-ChIP_GC-B_Human0.79156636
192ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78251963
193CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75184663
194TFEB_21752829_ChIP-Seq_HELA_Human0.75160079
195BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75105128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.18486879
2MP0003693_abnormal_embryo_hatching4.54848459
3MP0001666_abnormal_nutrient_absorption4.27138227
4MP0010234_abnormal_vibrissa_follicle4.09945809
5MP0005670_abnormal_white_adipose3.98627427
6MP0008058_abnormal_DNA_repair3.94537171
7MP0005085_abnormal_gallbladder_physiolo3.79804775
8MP0008057_abnormal_DNA_replication3.61290545
9MP0005410_abnormal_fertilization3.35096756
10MP0003111_abnormal_nucleus_morphology3.33521498
11MP0010094_abnormal_chromosome_stability3.27272485
12MP0002822_catalepsy3.14483776
13MP0008004_abnormal_stomach_pH3.06875225
14MP0005365_abnormal_bile_salt2.99720998
15MP0002139_abnormal_hepatobiliary_system2.98935809
16MP0003077_abnormal_cell_cycle2.82187813
17MP0008007_abnormal_cellular_replicative2.81304674
18MP0009840_abnormal_foam_cell2.79071399
19MP0003941_abnormal_skin_development2.70102546
20MP0004264_abnormal_extraembryonic_tissu2.66057800
21MP0003786_premature_aging2.60237357
22MP0001664_abnormal_digestion2.57159211
23MP0004019_abnormal_vitamin_homeostasis2.56735933
24MP0006292_abnormal_olfactory_placode2.52492147
25MP0001188_hyperpigmentation2.47351648
26MP0004957_abnormal_blastocyst_morpholog2.46329353
27MP0008877_abnormal_DNA_methylation2.32951191
28MP0000566_synostosis2.20068826
29MP0003186_abnormal_redox_activity2.11850829
30MP0003718_maternal_effect2.11286785
31MP0000462_abnormal_digestive_system2.07152326
32MP0003868_abnormal_feces_composition2.02103765
33MP0002132_abnormal_respiratory_system1.97884972
34MP0005171_absent_coat_pigmentation1.91093499
35MP0008932_abnormal_embryonic_tissue1.90082962
36MP0002277_abnormal_respiratory_mucosa1.86982091
37MP0004147_increased_porphyrin_level1.85228365
38MP0003806_abnormal_nucleotide_metabolis1.83666507
39MP0000490_abnormal_crypts_of1.80209531
40MP0002160_abnormal_reproductive_system1.69625132
41MP0000015_abnormal_ear_pigmentation1.63789639
42MP0009697_abnormal_copulation1.62290081
43MP0001756_abnormal_urination1.57449219
44MP0002148_abnormal_hypersensitivity_rea1.56460540
45MP0010329_abnormal_lipoprotein_level1.51055123
46MP0001835_abnormal_antigen_presentation1.50284905
47MP0005389_reproductive_system_phenotype1.50129279
48MP0003183_abnormal_peptide_metabolism1.50087302
49MP0005332_abnormal_amino_acid1.47625222
50MP0001765_abnormal_ion_homeostasis1.46001777
51MP0004272_abnormal_basement_membrane1.45808506
52MP0000678_abnormal_parathyroid_gland1.44687800
53MP0005075_abnormal_melanosome_morpholog1.44010936
54MP0005166_decreased_susceptibility_to1.43022604
55MP0001873_stomach_inflammation1.42982057
56MP0003866_abnormal_defecation1.42800670
57MP0002210_abnormal_sex_determination1.38468358
58MP0003283_abnormal_digestive_organ1.37361500
59MP0009785_altered_susceptibility_to1.36618077
60MP0000537_abnormal_urethra_morphology1.34440708
61MP0003252_abnormal_bile_duct1.32835696
62MP0005636_abnormal_mineral_homeostasis1.32389591
63MP0001119_abnormal_female_reproductive1.30199217
64MP0009643_abnormal_urine_homeostasis1.29314540
65MP0000230_abnormal_systemic_arterial1.25935846
66MP0003123_paternal_imprinting1.24121955
67MP0009333_abnormal_splenocyte_physiolog1.22505704
68MP0005381_digestive/alimentary_phenotyp1.20507443
69MP0000350_abnormal_cell_proliferation1.19487194
70MP0002396_abnormal_hematopoietic_system1.19260021
71MP0008789_abnormal_olfactory_epithelium1.18790348
72MP0001919_abnormal_reproductive_system1.18398862
73MP0010368_abnormal_lymphatic_system1.16827661
74MP0000470_abnormal_stomach_morphology1.16678938
75MP0000538_abnormal_urinary_bladder1.15676703
76MP0001853_heart_inflammation1.15602096
77MP0003315_abnormal_perineum_morphology1.15570530
78MP0002138_abnormal_hepatobiliary_system1.14968737
79MP0004484_altered_response_of1.14677315
80MP0002876_abnormal_thyroid_physiology1.14465542
81MP0002127_abnormal_cardiovascular_syste1.14463998
82MP0003763_abnormal_thymus_physiology1.13848785
83MP0001186_pigmentation_phenotype1.10583140
84MP0008995_early_reproductive_senescence1.07753470
85MP0005408_hypopigmentation1.07663514
86MP0000372_irregular_coat_pigmentation1.07287998
87MP0000313_abnormal_cell_death1.06899944
88MP0001764_abnormal_homeostasis1.05274762
89MP0001145_abnormal_male_reproductive1.04587573
90MP0001663_abnormal_digestive_system1.03782193
91MP0000516_abnormal_urinary_system1.03634101
92MP0005367_renal/urinary_system_phenotyp1.03634101
93MP0010352_gastrointestinal_tract_polyps1.03449458
94MP0009379_abnormal_foot_pigmentation1.02531024
95MP0008775_abnormal_heart_ventricle1.01778920
96MP0003879_abnormal_hair_cell1.01627263
97MP0005377_hearing/vestibular/ear_phenot1.00657831
98MP0003878_abnormal_ear_physiology1.00657831
99MP0004133_heterotaxia0.99921037
100MP0000858_altered_metastatic_potential0.99044893
101MP0001986_abnormal_taste_sensitivity0.98484742
102MP0001485_abnormal_pinna_reflex0.97592185
103MP0000653_abnormal_sex_gland0.97439883
104MP0010155_abnormal_intestine_physiology0.96980735
105MP0002019_abnormal_tumor_incidence0.96515467
106MP0002163_abnormal_gland_morphology0.93946551
107MP0005319_abnormal_enzyme/_coenzyme0.92661140
108MP0009115_abnormal_fat_cell0.92318911
109MP0008260_abnormal_autophagy0.91961706
110MP0005671_abnormal_response_to0.90889192
111MP0001905_abnormal_dopamine_level0.90310337
112MP0002419_abnormal_innate_immunity0.89718548
113MP0002136_abnormal_kidney_physiology0.89683586
114MP0002971_abnormal_brown_adipose0.89669963
115MP0002095_abnormal_skin_pigmentation0.89051457
116MP0003436_decreased_susceptibility_to0.88716260
117MP0005257_abnormal_intraocular_pressure0.87222246
118MP0005330_cardiomyopathy0.87024624
119MP0009780_abnormal_chondrocyte_physiolo0.86509100
120MP0000613_abnormal_salivary_gland0.84833953
121MP0003698_abnormal_male_reproductive0.84735564
122MP0003724_increased_susceptibility_to0.84440588
123MP0000749_muscle_degeneration0.83649977
124MP0004782_abnormal_surfactant_physiolog0.83114081
125MP0001929_abnormal_gametogenesis0.82915640
126MP0001529_abnormal_vocalization0.82898486
127MP0001542_abnormal_bone_strength0.82670505
128MP0002452_abnormal_antigen_presenting0.82007653
129MP0010030_abnormal_orbit_morphology0.81246964
130MP0005266_abnormal_metabolism0.79113180
131MP0006036_abnormal_mitochondrial_physio0.78907049
132MP0005394_taste/olfaction_phenotype0.77687878
133MP0005499_abnormal_olfactory_system0.77687878
134MP0002075_abnormal_coat/hair_pigmentati0.77463053
135MP0005174_abnormal_tail_pigmentation0.77222197
136MP0005000_abnormal_immune_tolerance0.75663284
137MP0000681_abnormal_thyroid_gland0.75637504
138MP0002796_impaired_skin_barrier0.75636073
139MP0010307_abnormal_tumor_latency0.75600858
140MP0003385_abnormal_body_wall0.75384418
141MP0006138_congestive_heart_failure0.74865101
142MP0001819_abnormal_immune_cell0.73379803
143MP0005595_abnormal_vascular_smooth0.72583762
144MP0002420_abnormal_adaptive_immunity0.72475273
145MP0004808_abnormal_hematopoietic_stem0.72384328
146MP0005025_abnormal_response_to0.71797286
147MP0003121_genomic_imprinting0.71717033
148MP0000689_abnormal_spleen_morphology0.70853878
149MP0005448_abnormal_energy_balance0.70606238
150MP0009764_decreased_sensitivity_to0.70601847
151MP0002398_abnormal_bone_marrow0.70591981
152MP0002722_abnormal_immune_system0.70082155
153MP0003936_abnormal_reproductive_system0.70010315
154MP0000371_diluted_coat_color0.69974060
155MP0005409_darkened_coat_color0.69898817
156MP0001672_abnormal_embryogenesis/_devel0.69755060
157MP0005380_embryogenesis_phenotype0.69755060
158MP0002118_abnormal_lipid_homeostasis0.68716013
159MP0000477_abnormal_intestine_morphology0.68321040
160MP0001440_abnormal_grooming_behavior0.66135192
161MP0001849_ear_inflammation0.64414026
162MP0004215_abnormal_myocardial_fiber0.62779483
163MP0000467_abnormal_esophagus_morphology0.62336457
164MP0005379_endocrine/exocrine_gland_phen0.62010078
165MP0004043_abnormal_pH_regulation0.60835461
166MP0004270_analgesia0.59315583
167MP0004858_abnormal_nervous_system0.58670138
168MP0003959_abnormal_lean_body0.58310453
169MP0005535_abnormal_body_temperature0.57165528
170MP0010678_abnormal_skin_adnexa0.54767430
171MP0005165_increased_susceptibility_to0.53297441
172MP0005376_homeostasis/metabolism_phenot0.50340302
173MP0003953_abnormal_hormone_level0.50316014
174MP0004085_abnormal_heartbeat0.50279667
175MP0001544_abnormal_cardiovascular_syste0.49870980
176MP0005385_cardiovascular_system_phenoty0.49870980
177MP0003119_abnormal_digestive_system0.49546640

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glutamine family amino acid metabolism (HP:0010902)5.62672678
2Birth length less than 3rd percentile (HP:0003561)5.17903685
3Hyperactive renin-angiotensin system (HP:0000841)5.05333451
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.90122490
5Chromsome breakage (HP:0040012)4.74537793
6Malnutrition (HP:0004395)4.70338828
7Metabolic alkalosis (HP:0200114)4.51113533
8Breast hypoplasia (HP:0003187)4.20698525
9Fat malabsorption (HP:0002630)4.19736610
10Decreased circulating renin level (HP:0003351)3.90101059
11Right ventricular cardiomyopathy (HP:0011663)3.85162646
12Ileus (HP:0002595)3.79177001
13Abnormality of proline metabolism (HP:0010907)3.69937073
14Hydroxyprolinuria (HP:0003080)3.69937073
15Abnormality of renin-angiotensin system (HP:0000847)3.65789759
16Intrahepatic cholestasis (HP:0001406)3.59167944
17Abnormality of the vitamin B12 metabolism (HP:0004341)3.49192493
18Type I transferrin isoform profile (HP:0003642)3.48283722
19Widely patent fontanelles and sutures (HP:0004492)3.45232139
20Hypobetalipoproteinemia (HP:0003563)3.38814430
21Abnormality of the costochondral junction (HP:0000919)3.34381139
22Abnormality of vitamin B metabolism (HP:0004340)3.34350589
23Meckel diverticulum (HP:0002245)3.12551548
24Conjugated hyperbilirubinemia (HP:0002908)3.12239673
25Duplicated collecting system (HP:0000081)3.08451668
26Abnormality of chromosome stability (HP:0003220)3.04295125
27Pigmentary retinal degeneration (HP:0001146)3.01478592
28Abnormality of the preputium (HP:0100587)2.99110104
29Abnormality of the renal collecting system (HP:0004742)2.98084564
30Abnormality of the ileum (HP:0001549)2.97608572
31Stomach cancer (HP:0012126)2.96143583
32Abnormal pancreas size (HP:0012094)2.94868653
33Abnormality of urine glucose concentration (HP:0011016)2.94126081
34Glycosuria (HP:0003076)2.94126081
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91015249
36Progressive external ophthalmoplegia (HP:0000590)2.86982495
37Alkalosis (HP:0001948)2.83044248
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.82596691
39Patellar aplasia (HP:0006443)2.81641507
40Congenital sensorineural hearing impairment (HP:0008527)2.80801267
41Reduced antithrombin III activity (HP:0001976)2.73633354
42Abnormal spermatogenesis (HP:0008669)2.72479232
43Abnormality of magnesium homeostasis (HP:0004921)2.68522806
44Aplasia/Hypoplasia of the patella (HP:0006498)2.67058273
45Thin bony cortex (HP:0002753)2.66656495
46Ectopic kidney (HP:0000086)2.65937277
47Hyperkalemia (HP:0002153)2.65437967
48Hypophosphatemic rickets (HP:0004912)2.64012089
49Abnormality of potassium homeostasis (HP:0011042)2.63413162
50Hyperphosphatemia (HP:0002905)2.62887756
51Potter facies (HP:0002009)2.61839603
52Facial shape deformation (HP:0011334)2.61839603
53Abdominal distention (HP:0003270)2.59996660
54Hyperparathyroidism (HP:0000843)2.57899015
55Neoplasm of the adrenal cortex (HP:0100641)2.56221751
56Pancreatic fibrosis (HP:0100732)2.55380073
57Granulocytopenia (HP:0001913)2.53635323
58Carpal bone hypoplasia (HP:0001498)2.52915905
59Steatorrhea (HP:0002570)2.50687483
60True hermaphroditism (HP:0010459)2.49962796
61Enlarged epiphyses (HP:0010580)2.49428645
62Confusion (HP:0001289)2.48853172
63Acanthocytosis (HP:0001927)2.47575300
64Clubbing of toes (HP:0100760)2.43969171
65Aplastic anemia (HP:0001915)2.43228485
66Hypokalemia (HP:0002900)2.42018400
67Type 2 muscle fiber atrophy (HP:0003554)2.41535127
68Bone marrow hypocellularity (HP:0005528)2.41015963
69Hyponatremia (HP:0002902)2.40618605
70Prostate neoplasm (HP:0100787)2.40404576
71Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39822004
72Abnormality of monocarboxylic acid metabolism (HP:0010996)2.39663116
73Azoospermia (HP:0000027)2.39352256
74Abnormality of chloride homeostasis (HP:0011422)2.36971938
75Abnormal biliary tract morphology (HP:0012440)2.36869643
76Abnormal tarsal ossification (HP:0008369)2.36864522
77Pili torti (HP:0003777)2.36444379
78Abnormality of vitamin metabolism (HP:0100508)2.35852506
79Premature graying of hair (HP:0002216)2.34915753
80Small intestinal stenosis (HP:0012848)2.34467885
81Duodenal stenosis (HP:0100867)2.34467885
82Pancreatic cysts (HP:0001737)2.34151930
83Posterior subcapsular cataract (HP:0007787)2.33561415
84Microretrognathia (HP:0000308)2.33515106
85Symptomatic seizures (HP:0011145)2.33127969
86Abnormal respiratory motile cilium physiology (HP:0012261)2.32176047
87Absent radius (HP:0003974)2.30951496
88Wide cranial sutures (HP:0010537)2.30733752
89Rough bone trabeculation (HP:0100670)2.30451056
90Absent thumb (HP:0009777)2.28841148
913-Methylglutaconic aciduria (HP:0003535)2.26638124
92Abnormal protein glycosylation (HP:0012346)2.26052107
93Abnormal glycosylation (HP:0012345)2.26052107
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26052107
95Abnormal protein N-linked glycosylation (HP:0012347)2.26052107
96Abnormality of carpal bone ossification (HP:0006257)2.25213492
97Reticulocytopenia (HP:0001896)2.24872616
98Rhabdomyolysis (HP:0003201)2.23614509
99Congenital malformation of the right heart (HP:0011723)2.22252090
100Double outlet right ventricle (HP:0001719)2.22252090
101Hypoalbuminemia (HP:0003073)2.21220081
102Abnormal albumin level (HP:0012116)2.21220081
10311 pairs of ribs (HP:0000878)2.20246982
104Spinal cord compression (HP:0002176)2.19216402
105Degeneration of anterior horn cells (HP:0002398)2.18666692
106Abnormality of the anterior horn cell (HP:0006802)2.18666692
107Facial cleft (HP:0002006)2.18486929
108Flattened epiphyses (HP:0003071)2.18413048
109Aplasia involving forearm bones (HP:0009822)2.18342364
110Absent forearm bone (HP:0003953)2.18342364
111Hyperaldosteronism (HP:0000859)2.18197395
112Focal segmental glomerulosclerosis (HP:0000097)2.16601406
113Alveolar cell carcinoma (HP:0006519)2.16051077
114Flat acetabular roof (HP:0003180)2.14080359
115Myoglobinuria (HP:0002913)2.13883139
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13798665
117Proximal tubulopathy (HP:0000114)2.12468511
118Curly hair (HP:0002212)2.11083575
119Hypolipoproteinemia (HP:0010981)2.10911818
120Chronic diarrhea (HP:0002028)2.09036065
121Aplasia/Hypoplasia involving the musculature (HP:0001460)2.08635729
122Hypoglycemic seizures (HP:0002173)2.07133655
123Exocrine pancreatic insufficiency (HP:0001738)2.07046701
124Impulsivity (HP:0100710)2.06234877
125Syncope (HP:0001279)2.06230481
126Nephrolithiasis (HP:0000787)2.06224455
127Aplasia/hypoplasia of the uterus (HP:0008684)2.05962168
128Myelodysplasia (HP:0002863)2.05374156
129Microvesicular hepatic steatosis (HP:0001414)2.04953520
130Delayed epiphyseal ossification (HP:0002663)2.04121250
131Esophageal atresia (HP:0002032)2.01648811
132Aplasia/Hypoplasia of the sacrum (HP:0008517)2.00880272
133Neonatal short-limb short stature (HP:0008921)2.00179002
134Male infertility (HP:0003251)1.99351201
135Optic nerve coloboma (HP:0000588)1.97710445
136Abnormality of the aortic arch (HP:0012303)1.97049709
137Partial duplication of thumb phalanx (HP:0009944)1.96920316
138Hypergonadotropic hypogonadism (HP:0000815)1.95240409
139Rhinitis (HP:0012384)1.93425334
140Muscle fiber atrophy (HP:0100295)1.93413586
141Irregular epiphyses (HP:0010582)1.93022633
142Abnormality of purine metabolism (HP:0004352)1.92404296
143White forelock (HP:0002211)1.92330182
144Renal cortical cysts (HP:0000803)1.92071753
145Triphalangeal thumb (HP:0001199)1.91529106
146Rickets (HP:0002748)1.91421884
147Prolonged neonatal jaundice (HP:0006579)1.90982452
148Partial duplication of the phalanx of hand (HP:0009999)1.90715547
149Cleft eyelid (HP:0000625)1.90143947
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89319906
151Aplasia cutis congenita (HP:0001057)1.88981368
152Supernumerary spleens (HP:0009799)1.88304413
153Patchy hypopigmentation of hair (HP:0011365)1.88169015
154Long foot (HP:0001833)1.87429276
155Abnormality of the duodenum (HP:0002246)1.87198134
156Hyperphosphaturia (HP:0003109)1.86683555
157Hypophosphatemia (HP:0002148)1.86668091
158Multiple lipomas (HP:0001012)1.85942908
159Oral leukoplakia (HP:0002745)1.85423129
160Recurrent corneal erosions (HP:0000495)1.84428290
161Preaxial hand polydactyly (HP:0001177)1.83937108
162Abnormal trabecular bone morphology (HP:0100671)1.83787653
163Breast aplasia (HP:0100783)1.83490515
164Distal lower limb muscle weakness (HP:0009053)1.83110960
165Abnormal lung lobation (HP:0002101)1.82991274
166Subcapsular cataract (HP:0000523)1.81410918
167Abnormal number of erythroid precursors (HP:0012131)1.81000467
168Osteomalacia (HP:0002749)1.80209343
169Hypoplasia of the fovea (HP:0007750)1.79678637
170Aplasia/Hypoplasia of the fovea (HP:0008060)1.79678637
171Sloping forehead (HP:0000340)1.79513729
172Pancytopenia (HP:0001876)1.79437211
173Abnormal hand bone ossification (HP:0010660)1.78987221
174Short thumb (HP:0009778)1.78477912
175External ophthalmoplegia (HP:0000544)1.78231188
176Hyperuricemia (HP:0002149)1.77912526
177Increased purine levels (HP:0004368)1.77912526
178Optic neuritis (HP:0100653)1.77833480
179Retrobulbar optic neuritis (HP:0100654)1.77833480
180Increased serum lactate (HP:0002151)1.76965866
181Adrenal overactivity (HP:0002717)1.76300669
182Median cleft lip (HP:0000161)1.75588305
183Broad metatarsal (HP:0001783)1.74797828
184Aplasia/Hypoplasia of the breasts (HP:0010311)1.74191123
185Breech presentation (HP:0001623)1.73898735
186Tracheoesophageal fistula (HP:0002575)1.73841050
187Sparse eyelashes (HP:0000653)1.73639002
188Abnormal ciliary motility (HP:0012262)1.73408664
189Abnormal urine phosphate concentration (HP:0012599)1.73330725
190Megaloblastic anemia (HP:0001889)1.72345608
191Lymphoma (HP:0002665)1.70245188
192Horseshoe kidney (HP:0000085)1.69854281
193Exertional dyspnea (HP:0002875)1.67473593
194Intestinal atresia (HP:0011100)1.67323493
195Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65857197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.60746825
2PLK44.55363819
3ZAK4.32871581
4MST1R3.67187704
5BUB13.24059254
6IRAK42.83605134
7PIK3CA2.71787231
8STK162.51804356
9SRPK12.47417493
10MAP3K122.31230138
11EIF2AK12.31200965
12STK392.22861526
13PRKG22.14368696
14DDR22.13335000
15EIF2AK32.13261037
16WEE12.12466076
17PINK12.12142831
18AKT31.96508094
19PBK1.94524999
20RIPK11.92295985
21TTK1.84154314
22LMTK21.81264818
23MAP2K61.69814413
24STK38L1.64188453
25CDC71.63114114
26EPHA21.62725590
27FGFR21.56033681
28EIF2AK21.54578815
29VRK11.52348957
30PLK31.50423945
31PIM21.45955004
32PLK11.44433920
33FRK1.44092624
34IRAK21.43494311
35MAP3K141.41914224
36BRSK21.37256088
37TSSK61.36573660
38IRAK11.34970982
39ATR1.34443017
40MST41.33642578
41ERBB31.27146810
42ACVR1B1.24271983
43MAP3K51.22837847
44NEK61.21383866
45BMPR21.21180446
46MKNK11.20871391
47MKNK21.19741976
48MET1.18998112
49TXK1.18093136
50TESK11.14455580
51RPS6KB21.14260729
52EPHA41.12499284
53MARK11.10379897
54OXSR11.08153850
55PRPF4B0.96873389
56MAP4K20.96332223
57LATS10.94820366
58MAP3K10.94195094
59TAOK20.94011110
60IKBKB0.93946985
61NME10.93239630
62SIK30.92881599
63AURKB0.89265482
64MAPKAPK30.88741620
65MARK30.87977935
66MAP3K100.87560261
67NUAK10.87477843
68PASK0.87327793
69CHEK20.86416994
70STK40.86306125
71PRKCI0.85535307
72MAP3K80.85157063
73BRSK10.84516071
74TESK20.84427066
75NME20.82733956
76OBSCN0.82649299
77ERBB40.80382213
78TEC0.78982439
79YES10.78657608
80BMPR1B0.77500279
81CDK70.75140523
82TLK10.75120041
83CLK10.72892290
84CDK80.71874246
85STK380.70137104
86PDPK10.69963295
87BRAF0.67755941
88AURKA0.67614290
89CHUK0.67116326
90LATS20.66895364
91ARAF0.66322195
92BRD40.64610225
93EPHB20.62076853
94DYRK30.61819702
95STK30.61540232
96ADRBK20.60744136
97MAP3K20.59557059
98INSRR0.57860489
99RPS6KA40.56200596
100PIM10.56116394
101GRK10.54726625
102PLK20.54505018
103PRKAA20.54298119
104MAP2K20.52989430
105MAPK70.52519220
106CCNB10.52319753
107MAP3K30.51896426
108CHEK10.51855229
109STK240.51258899
110ATM0.50876417
111TNIK0.50342067
112PTK20.49476077
113NEK20.49219192
114CSNK2A10.48694636
115PDK20.48276038
116NEK10.47995224
117PAK40.47931410
118MELK0.45431040
119CAMK2D0.44781457
120TIE10.44381389
121ICK0.44317533
122PAK30.42447211
123IKBKE0.41767984
124MAP2K70.41627659
125RPS6KA50.41484559
126PDK10.41349698
127WNK40.40502056
128NLK0.40164359
129CASK0.39749831
130LIMK10.39610992
131ABL20.39326050
132MYLK0.39055678
133ERN10.38706981
134JAK30.38008484
135DYRK20.37343067
136TAOK10.37317543
137CDK30.37153444
138TRPM70.36949937
139GRK70.35566196
140ROCK10.35564742
141KDR0.34791712
142MAP3K90.33484814
143ILK0.33233095
144PTK60.33231833
145CDC42BPA0.30214756
146STK100.28633248
147PRKG10.28287500
148BCR0.28079228
149CSNK2A20.28062428
150FER0.28017311
151PAK20.26060554
152TRIM280.24888621
153DAPK30.24337186
154PRKCA0.22003360
155PRKCQ0.21810730
156PIK3CG0.21546278
157PRKAA10.21328357
158MINK10.18760501
159CDK50.17850081
160PRKACG0.17699929
161RPS6KB10.17556493
162CDK140.14997597
163CSNK1A10.14322614

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19573714
2RNA polymerase_Homo sapiens_hsa030203.70976329
3Fat digestion and absorption_Homo sapiens_hsa049753.66620430
4Proteasome_Homo sapiens_hsa030503.61190468
5Mismatch repair_Homo sapiens_hsa034303.50705612
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.35815989
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26073546
8Homologous recombination_Homo sapiens_hsa034403.03734313
9Cyanoamino acid metabolism_Homo sapiens_hsa004603.01648327
10Renin-angiotensin system_Homo sapiens_hsa046142.85471739
11Pyrimidine metabolism_Homo sapiens_hsa002402.75351922
12Fanconi anemia pathway_Homo sapiens_hsa034602.65518040
13Protein digestion and absorption_Homo sapiens_hsa049742.54978517
14Base excision repair_Homo sapiens_hsa034102.52486912
15Caffeine metabolism_Homo sapiens_hsa002322.42371958
16Arginine biosynthesis_Homo sapiens_hsa002202.41656248
17Ribosome_Homo sapiens_hsa030102.40127200
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.39815043
19Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.38749501
20Nitrogen metabolism_Homo sapiens_hsa009102.36319692
21Spliceosome_Homo sapiens_hsa030402.35901066
22Nucleotide excision repair_Homo sapiens_hsa034202.33439920
23One carbon pool by folate_Homo sapiens_hsa006702.33203280
24Maturity onset diabetes of the young_Homo sapiens_hsa049502.30661818
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30324400
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.08354667
27Basal transcription factors_Homo sapiens_hsa030222.06166822
28Non-homologous end-joining_Homo sapiens_hsa034502.03198674
29Starch and sucrose metabolism_Homo sapiens_hsa005002.01436060
30RNA transport_Homo sapiens_hsa030132.00311590
31Retinol metabolism_Homo sapiens_hsa008301.86803421
32Cell cycle_Homo sapiens_hsa041101.83281957
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.81614245
34RNA degradation_Homo sapiens_hsa030181.80665672
35Purine metabolism_Homo sapiens_hsa002301.72312745
36PPAR signaling pathway_Homo sapiens_hsa033201.63521719
37Fatty acid degradation_Homo sapiens_hsa000711.60821743
38Histidine metabolism_Homo sapiens_hsa003401.59867850
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50057282
40Bile secretion_Homo sapiens_hsa049761.47658392
41p53 signaling pathway_Homo sapiens_hsa041151.46668029
42Sulfur relay system_Homo sapiens_hsa041221.43587244
43Pancreatic secretion_Homo sapiens_hsa049721.43276592
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33867623
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26591721
46Renin secretion_Homo sapiens_hsa049241.25466238
47Protein export_Homo sapiens_hsa030601.24508316
48Arginine and proline metabolism_Homo sapiens_hsa003301.23632330
49Graft-versus-host disease_Homo sapiens_hsa053321.18452536
50Arachidonic acid metabolism_Homo sapiens_hsa005901.16146487
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.12567222
52Epstein-Barr virus infection_Homo sapiens_hsa051691.12037081
53Glutathione metabolism_Homo sapiens_hsa004801.11809291
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09915698
55Allograft rejection_Homo sapiens_hsa053301.07266168
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.04173612
57NF-kappa B signaling pathway_Homo sapiens_hsa040641.02808530
58Butanoate metabolism_Homo sapiens_hsa006501.01348457
59Glycerolipid metabolism_Homo sapiens_hsa005611.00887114
60Propanoate metabolism_Homo sapiens_hsa006400.98667907
61Oxidative phosphorylation_Homo sapiens_hsa001900.97238483
62Legionellosis_Homo sapiens_hsa051340.96574919
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.95966733
64Huntingtons disease_Homo sapiens_hsa050160.95919713
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95682972
66Herpes simplex infection_Homo sapiens_hsa051680.94199984
67mRNA surveillance pathway_Homo sapiens_hsa030150.93832346
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93731239
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93231505
70Tryptophan metabolism_Homo sapiens_hsa003800.92050129
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88343922
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88107992
73Other glycan degradation_Homo sapiens_hsa005110.87675432
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83897730
75Fatty acid metabolism_Homo sapiens_hsa012120.83202857
76Parkinsons disease_Homo sapiens_hsa050120.83108294
77Autoimmune thyroid disease_Homo sapiens_hsa053200.81841980
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.79898156
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78891672
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78631395
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76722187
82Fatty acid biosynthesis_Homo sapiens_hsa000610.76663366
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.76562683
84Galactose metabolism_Homo sapiens_hsa000520.72511278
85Pyruvate metabolism_Homo sapiens_hsa006200.71863678
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71629444
87Measles_Homo sapiens_hsa051620.71555121
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70901775
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70703690
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.68468481
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67412519
92Linoleic acid metabolism_Homo sapiens_hsa005910.66146539
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65578080
94Folate biosynthesis_Homo sapiens_hsa007900.65541474
95Cocaine addiction_Homo sapiens_hsa050300.64687277
96Leishmaniasis_Homo sapiens_hsa051400.63756228
97Asthma_Homo sapiens_hsa053100.60738041
98Systemic lupus erythematosus_Homo sapiens_hsa053220.60394402
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57446765
100Cardiac muscle contraction_Homo sapiens_hsa042600.57088230
101Vitamin digestion and absorption_Homo sapiens_hsa049770.56771359
102Tyrosine metabolism_Homo sapiens_hsa003500.56736960
103Influenza A_Homo sapiens_hsa051640.55625468
104Type I diabetes mellitus_Homo sapiens_hsa049400.55298035
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.54815272
106Sphingolipid metabolism_Homo sapiens_hsa006000.52895573
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52184203
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51447898
109TGF-beta signaling pathway_Homo sapiens_hsa043500.50443482
110Peroxisome_Homo sapiens_hsa041460.50232678
111Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49732151
112Fructose and mannose metabolism_Homo sapiens_hsa000510.48577077
113Rheumatoid arthritis_Homo sapiens_hsa053230.47381952
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46932359
115Gap junction_Homo sapiens_hsa045400.46795044
116Apoptosis_Homo sapiens_hsa042100.45712862
117Pentose phosphate pathway_Homo sapiens_hsa000300.44809009
118Dorso-ventral axis formation_Homo sapiens_hsa043200.44701793
119Sulfur metabolism_Homo sapiens_hsa009200.44487437
120Toll-like receptor signaling pathway_Homo sapiens_hsa046200.44480659
121Olfactory transduction_Homo sapiens_hsa047400.44224540
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44127879
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43205483
124Fatty acid elongation_Homo sapiens_hsa000620.42235453
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42119786
126Insulin secretion_Homo sapiens_hsa049110.41948833
127Metabolic pathways_Homo sapiens_hsa011000.41799197
128HTLV-I infection_Homo sapiens_hsa051660.40981552
129Tight junction_Homo sapiens_hsa045300.40756172
130Viral carcinogenesis_Homo sapiens_hsa052030.40509451
131ABC transporters_Homo sapiens_hsa020100.39363929
132Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38853484
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37810989
134Chemical carcinogenesis_Homo sapiens_hsa052040.37655288
135Hematopoietic cell lineage_Homo sapiens_hsa046400.37520258
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37089915
137Antigen processing and presentation_Homo sapiens_hsa046120.36922865
138Primary immunodeficiency_Homo sapiens_hsa053400.35454186
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.33434360
140Shigellosis_Homo sapiens_hsa051310.32358582
141Pertussis_Homo sapiens_hsa051330.32270971
142Phenylalanine metabolism_Homo sapiens_hsa003600.30190046
143Mineral absorption_Homo sapiens_hsa049780.29604623
144Selenocompound metabolism_Homo sapiens_hsa004500.29509576
145Regulation of autophagy_Homo sapiens_hsa041400.29050475
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28792598
147Gastric acid secretion_Homo sapiens_hsa049710.28644986
148N-Glycan biosynthesis_Homo sapiens_hsa005100.28553672
149Glucagon signaling pathway_Homo sapiens_hsa049220.26822683
150Vitamin B6 metabolism_Homo sapiens_hsa007500.26518353
151Amphetamine addiction_Homo sapiens_hsa050310.26462281
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26218198
153Salivary secretion_Homo sapiens_hsa049700.25961307
154TNF signaling pathway_Homo sapiens_hsa046680.25391476
155Ether lipid metabolism_Homo sapiens_hsa005650.24853973
156Glycosaminoglycan degradation_Homo sapiens_hsa005310.24643490
157Alzheimers disease_Homo sapiens_hsa050100.23980211
158Collecting duct acid secretion_Homo sapiens_hsa049660.23417006
159cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23385213
160Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22939112
161Carbon metabolism_Homo sapiens_hsa012000.20578397
162beta-Alanine metabolism_Homo sapiens_hsa004100.19937291
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19717152
164Vibrio cholerae infection_Homo sapiens_hsa051100.15670323
165Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14997494
166Thyroid hormone synthesis_Homo sapiens_hsa049180.12498253

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »