REPIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.61799439
2L-phenylalanine catabolic process (GO:0006559)6.61799439
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.26316051
4L-phenylalanine metabolic process (GO:0006558)6.26316051
5aromatic amino acid family catabolic process (GO:0009074)5.94384335
6glyoxylate metabolic process (GO:0046487)5.63199601
7indole-containing compound catabolic process (GO:0042436)5.52062875
8indolalkylamine catabolic process (GO:0046218)5.52062875
9tryptophan catabolic process (GO:0006569)5.52062875
10bile acid biosynthetic process (GO:0006699)5.37331048
11tryptophan metabolic process (GO:0006568)5.28959461
12alpha-linolenic acid metabolic process (GO:0036109)5.28060880
13kynurenine metabolic process (GO:0070189)5.25842053
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.03801334
15sulfur amino acid catabolic process (GO:0000098)5.00002134
16lysine metabolic process (GO:0006553)4.94588970
17lysine catabolic process (GO:0006554)4.94588970
18proline biosynthetic process (GO:0006561)4.83756545
19negative regulation of erythrocyte differentiation (GO:0045647)4.79212512
20urea cycle (GO:0000050)4.79211185
21urea metabolic process (GO:0019627)4.79211185
22serine family amino acid catabolic process (GO:0009071)4.75773315
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.72290920
24cysteine metabolic process (GO:0006534)4.68724226
25high-density lipoprotein particle remodeling (GO:0034375)4.52508070
26alpha-amino acid catabolic process (GO:1901606)4.48272968
27negative regulation of fibrinolysis (GO:0051918)4.45052509
28nitrogen cycle metabolic process (GO:0071941)4.34883394
29COPI coating of Golgi vesicle (GO:0048205)4.33797201
30Golgi transport vesicle coating (GO:0048200)4.33797201
31amino-acid betaine metabolic process (GO:0006577)4.33336870
32bile acid metabolic process (GO:0008206)4.33167369
33cellular modified amino acid catabolic process (GO:0042219)4.21880881
34regulation of protein activation cascade (GO:2000257)4.20562217
35regulation of fibrinolysis (GO:0051917)4.20508290
36regulation of cholesterol esterification (GO:0010872)4.20277226
37aromatic amino acid family metabolic process (GO:0009072)4.19469332
38NADH metabolic process (GO:0006734)4.19392904
39cellular amino acid catabolic process (GO:0009063)4.17063963
40imidazole-containing compound metabolic process (GO:0052803)4.14309884
412-oxoglutarate metabolic process (GO:0006103)4.11936431
42glutamate metabolic process (GO:0006536)4.11766790
43glycine metabolic process (GO:0006544)4.11202209
44negative regulation of cell size (GO:0045792)4.11019272
45cellular ketone body metabolic process (GO:0046950)4.07856172
46tyrosine metabolic process (GO:0006570)4.04681300
47serine family amino acid biosynthetic process (GO:0009070)4.03170198
48reverse cholesterol transport (GO:0043691)4.00915483
49low-density lipoprotein particle remodeling (GO:0034374)3.99918264
50complement activation, alternative pathway (GO:0006957)3.98229826
51dicarboxylic acid biosynthetic process (GO:0043650)3.96732451
52protein-lipid complex remodeling (GO:0034368)3.95704168
53macromolecular complex remodeling (GO:0034367)3.95704168
54plasma lipoprotein particle remodeling (GO:0034369)3.95704168
55serine family amino acid metabolic process (GO:0009069)3.93107059
56indolalkylamine metabolic process (GO:0006586)3.89901983
57regulation of complement activation (GO:0030449)3.87351348
58protein carboxylation (GO:0018214)3.86396344
59peptidyl-glutamic acid carboxylation (GO:0017187)3.86396344
60apoptotic process involved in morphogenesis (GO:0060561)3.84927903
61amine catabolic process (GO:0009310)3.79224278
62cellular biogenic amine catabolic process (GO:0042402)3.79224278
63coenzyme catabolic process (GO:0009109)3.74581356
64regulation of triglyceride catabolic process (GO:0010896)3.72940735
65negative regulation of cholesterol transport (GO:0032375)3.72813196
66negative regulation of sterol transport (GO:0032372)3.72813196
67homocysteine metabolic process (GO:0050667)3.70337827
68oxaloacetate metabolic process (GO:0006107)3.66138709
69proline metabolic process (GO:0006560)3.64998993
70ethanol oxidation (GO:0006069)3.63399771
71organic acid catabolic process (GO:0016054)3.61757239
72carboxylic acid catabolic process (GO:0046395)3.61757239
73cholesterol catabolic process (GO:0006707)3.61299732
74sterol catabolic process (GO:0016127)3.61299732
75mannose metabolic process (GO:0006013)3.61260497
76benzene-containing compound metabolic process (GO:0042537)3.59641635
77maternal placenta development (GO:0001893)3.54408436
78valine metabolic process (GO:0006573)3.54378609
79activation of Rac GTPase activity (GO:0032863)3.52652571
80phospholipid efflux (GO:0033700)3.51561411
81regulation of mammary gland epithelial cell proliferation (GO:0033599)3.51042232
82aspartate family amino acid catabolic process (GO:0009068)3.50958878
83ketone body metabolic process (GO:1902224)3.50833792
84carnitine metabolic process (GO:0009437)3.50621679
85arginine metabolic process (GO:0006525)3.50355079
86retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.49881895
87short-chain fatty acid metabolic process (GO:0046459)3.49541875
88triglyceride homeostasis (GO:0070328)3.48622017
89acylglycerol homeostasis (GO:0055090)3.48622017
90NAD biosynthetic process (GO:0009435)3.43315193
91branched-chain amino acid catabolic process (GO:0009083)3.40095816
92regulation of translational fidelity (GO:0006450)3.37996035
93regulation of early endosome to late endosome transport (GO:2000641)3.37468878
94monocarboxylic acid catabolic process (GO:0072329)3.35675204
95cellular glucuronidation (GO:0052695)3.35620385
96adherens junction assembly (GO:0034333)3.33941073
97regulation of cholesterol metabolic process (GO:0090181)3.33586198
98fatty acid beta-oxidation (GO:0006635)3.31882844
99flavonoid metabolic process (GO:0009812)3.31881537
100plasma lipoprotein particle assembly (GO:0034377)3.31143896
1013-UTR-mediated mRNA stabilization (GO:0070935)3.29892144
102cell-substrate adherens junction assembly (GO:0007045)3.29470681
103focal adhesion assembly (GO:0048041)3.29470681
104L-serine metabolic process (GO:0006563)3.27817585
105fatty acid oxidation (GO:0019395)3.27534143
106bile acid and bile salt transport (GO:0015721)3.26541005
107lipid oxidation (GO:0034440)3.25327839
108succinate metabolic process (GO:0006105)3.25069186
109very-low-density lipoprotein particle assembly (GO:0034379)3.24839364
110tricarboxylic acid metabolic process (GO:0072350)3.24460208
111branched-chain amino acid metabolic process (GO:0009081)3.24328518
112regulation of cholesterol biosynthetic process (GO:0045540)3.23959608
113very long-chain fatty acid metabolic process (GO:0000038)3.22870091
114regulation of chromatin binding (GO:0035561)3.21522428
115blood coagulation, intrinsic pathway (GO:0007597)3.20182111
116planar cell polarity pathway involved in neural tube closure (GO:0090179)3.20103577
117regulation of histone H3-K27 methylation (GO:0061085)3.19168019
118pyridine nucleotide biosynthetic process (GO:0019363)3.17348731
119nicotinamide nucleotide biosynthetic process (GO:0019359)3.17348731
120intracellular estrogen receptor signaling pathway (GO:0030520)3.17057675
121epithelial cell differentiation involved in prostate gland development (GO:0060742)3.16965442
122negative regulation of protein activation cascade (GO:2000258)3.16914294
123one-carbon metabolic process (GO:0006730)3.16897807
124positive regulation of histone deacetylation (GO:0031065)3.16532628
125peptidyl-tyrosine autophosphorylation (GO:0038083)3.15509496
126negative regulation of myotube differentiation (GO:0010832)3.13866892
127DNA unwinding involved in DNA replication (GO:0006268)3.13713139
128drug transmembrane transport (GO:0006855)3.11971287
129activation of MAPKKK activity (GO:0000185)3.07282031
130mitotic chromosome condensation (GO:0007076)3.03276130
131creatine metabolic process (GO:0006600)3.01489445
132pentose-phosphate shunt (GO:0006098)3.00870131
133protein retention in ER lumen (GO:0006621)3.00648196
134semaphorin-plexin signaling pathway (GO:0071526)3.00341583
135regulation of NFAT protein import into nucleus (GO:0051532)2.99587185
136regulation of cholesterol homeostasis (GO:2000188)2.98621850
137spliceosomal tri-snRNP complex assembly (GO:0000244)2.93620794
138glucose catabolic process (GO:0006007)2.93225759
139regulation of fatty acid beta-oxidation (GO:0031998)2.91250397
140maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.90376372
141positive regulation of Cdc42 GTPase activity (GO:0043089)2.85592776
142RNA stabilization (GO:0043489)2.84731117
143mRNA stabilization (GO:0048255)2.84731117
144regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84166174
145intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.84151978
146glucose 6-phosphate metabolic process (GO:0051156)2.83159920
147activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74913483
148negative regulation of viral release from host cell (GO:1902187)2.74327537
149negative regulation of fatty acid transport (GO:2000192)2.73785064
150cellular response to epidermal growth factor stimulus (GO:0071364)2.71617318
151regulation of RNA export from nucleus (GO:0046831)2.71269221
152regulation of nucleobase-containing compound transport (GO:0032239)2.70524831
153nucleosome disassembly (GO:0006337)2.69945481
154protein-DNA complex disassembly (GO:0032986)2.69945481
155positive regulation of nuclease activity (GO:0032075)2.69317537
156ribosomal small subunit biogenesis (GO:0042274)2.68718562
157atrioventricular valve morphogenesis (GO:0003181)2.66085796
158glutamine family amino acid biosynthetic process (GO:0009084)2.65342357
159cytoskeletal anchoring at plasma membrane (GO:0007016)2.64988922
160negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.64013978
161* regulation of glucose import in response to insulin stimulus (GO:2001273)2.61715448
162cell-cell junction maintenance (GO:0045217)2.61313022
163positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.59107466
164regulation of endothelial cell chemotaxis (GO:2001026)2.58406726
165basement membrane organization (GO:0071711)2.55251039
166negative regulation of striated muscle cell differentiation (GO:0051154)2.54253955
167modulation by symbiont of host cellular process (GO:0044068)2.53660299
168negative regulation of fatty acid biosynthetic process (GO:0045717)2.53276729
169modulation by virus of host morphology or physiology (GO:0019048)2.53138085
170epithelial cell-cell adhesion (GO:0090136)2.52992518
171modulation by virus of host process (GO:0019054)2.52940069
172insulin-like growth factor receptor signaling pathway (GO:0048009)2.49693029
173histone H4 deacetylation (GO:0070933)2.49691518
174NADPH regeneration (GO:0006740)2.49688970
175protein localization to endosome (GO:0036010)2.48084424
176snRNA metabolic process (GO:0016073)2.47160288
177fructose metabolic process (GO:0006000)2.46124964
178embryonic eye morphogenesis (GO:0048048)2.45978105
179positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.45568413
180vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.44951632
181positive regulation of myotube differentiation (GO:0010831)2.44128789
182branching involved in mammary gland duct morphogenesis (GO:0060444)2.41756290
183thymic T cell selection (GO:0045061)2.40795084
184positive regulation of gene expression, epigenetic (GO:0045815)2.40691331
185embryonic camera-type eye morphogenesis (GO:0048596)2.40659078
186apoptotic process involved in development (GO:1902742)2.39315914
187regulation of nuclease activity (GO:0032069)2.38238398
188monosaccharide biosynthetic process (GO:0046364)2.37679831
189regulation of ARF GTPase activity (GO:0032312)2.36897165
190gluconeogenesis (GO:0006094)2.36150483
191poly(A)+ mRNA export from nucleus (GO:0016973)2.36064737
192positive regulation of protein deacetylation (GO:0090312)2.34772405
193peptidyl-lysine dimethylation (GO:0018027)2.33488712

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.12214646
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.99549309
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.94464976
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.20682362
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.84675816
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.64821125
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.62602619
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.05935575
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.15338645
10VDR_21846776_ChIP-Seq_THP-1_Human3.06314665
11SCL_19346495_ChIP-Seq_HPC-7_Human2.94766175
12GATA1_22025678_ChIP-Seq_K562_Human2.38436355
13* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.37100769
14* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.35327094
15* RACK7_27058665_Chip-Seq_MCF-7_Human2.31851309
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.30010977
17ZNF263_19887448_ChIP-Seq_K562_Human2.27042126
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25986013
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.23564307
20* TCF7_22412390_ChIP-Seq_EML_Mouse2.19997688
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11827627
22TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10231012
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.08391273
24* KDM2B_26808549_Chip-Seq_DND41_Human2.07251396
25E2F7_22180533_ChIP-Seq_HELA_Human2.04310497
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03973449
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.03081404
28ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6769879
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86444159
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75362157
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.74972225
32* KDM2B_26808549_Chip-Seq_K562_Human1.74599632
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67790251
34* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66963566
35P68_20966046_ChIP-Seq_HELA_Human1.66496257
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.65803965
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.60766243
38VDR_24763502_ChIP-Seq_THP-1_Human1.56433947
39* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55693272
40DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55595149
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.53032916
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.53020791
43CREB1_26743006_Chip-Seq_LNCaP_Human1.51692012
44HTT_18923047_ChIP-ChIP_STHdh_Human1.49399220
45SMC4_20622854_ChIP-Seq_HELA_Human1.48594261
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.47698437
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47607171
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47211326
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.46326915
50MAF_26560356_Chip-Seq_TH1_Human1.42375656
51CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41704983
52* NCOR1_26117541_ChIP-Seq_K562_Human1.40368781
53* KDM2B_26808549_Chip-Seq_JURKAT_Human1.37979094
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.36645047
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36475585
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36347074
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35670424
58CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34956584
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34424389
60* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31662466
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31411077
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30685997
63FOXM1_23109430_ChIP-Seq_U2OS_Human1.29646055
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28167927
65CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27238634
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26794510
67* MAF_26560356_Chip-Seq_TH2_Human1.26463566
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.26335445
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25810859
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.24274052
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22464108
72* UTX_26944678_Chip-Seq_JUKART_Human1.22188794
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21848340
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21522620
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19546736
76* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.18947307
77TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18653577
78* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18391168
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17633575
80XRN2_22483619_ChIP-Seq_HELA_Human1.15252010
81MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14817905
82ATF3_27146783_Chip-Seq_COLON_Human1.14705498
83* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14181255
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13278585
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.13030081
86* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11911467
87CLOCK_20551151_ChIP-Seq_293T_Human1.11720459
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.11094950
89CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10262057
90ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07851415
91MYC_19079543_ChIP-ChIP_MESCs_Mouse1.07322245
92* MYC_18555785_ChIP-Seq_MESCs_Mouse1.06080043
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05098672
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02599027
95HNF4A_19822575_ChIP-Seq_HepG2_Human1.02320009
96FOXA2_19822575_ChIP-Seq_HepG2_Human1.02291984
97* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01463492
98PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98880127
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98812233
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98206630
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96852469
102ETS1_21867929_ChIP-Seq_TH2_Mouse0.96233025
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92322014
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91347265
105* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89612309
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89599921
107GATA1_19941827_ChIP-Seq_MEL_Mouse0.89133690
108RARA_24833708_ChIP-Seq_LIVER_Mouse0.89067812
109CIITA_25753668_ChIP-Seq_RAJI_Human0.88643502
110SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87738603
111BCL6_27268052_Chip-Seq_Bcells_Human0.86725912
112DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84854227
113ERG_20517297_ChIP-Seq_VCAP_Human0.84778981
114* AR_20517297_ChIP-Seq_VCAP_Human0.84607191
115LXR_22292898_ChIP-Seq_THP-1_Human0.84375957
116GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83259294
117GATA4_21415370_ChIP-Seq_HL-1_Mouse0.83126431
118MYC_22102868_ChIP-Seq_BL_Human0.83002002
119RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80142098
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.79422117
121LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.78994395
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77942732
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77744161
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.76897147
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.76735896
126ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.76467955
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75088442
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.71717805
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.71492650
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71372944
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.69988370
132ERG_20887958_ChIP-Seq_HPC-7_Mouse0.68322966
133BCOR_27268052_Chip-Seq_Bcells_Human0.66846085
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.66535442
135NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64921113
136* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.64766850
137SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.63571724
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63012343
139RARB_24833708_ChIP-Seq_LIVER_Mouse0.62419249
140SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61305100
141PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61301706
142IRF1_19129219_ChIP-ChIP_H3396_Human0.60905700
143* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60655958
144RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59652451
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.58523393
146SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.58198818
147REST_18959480_ChIP-ChIP_MESCs_Mouse0.58141790
148GBX2_23144817_ChIP-Seq_PC3_Human0.57964007
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56374496
150GATA1_22383799_ChIP-Seq_G1ME_Mouse0.55519905
151MYC_27129775_Chip-Seq_CORNEA_Mouse0.55005342
152GATA1_19941826_ChIP-Seq_K562_Human0.54708570
153OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.53730960
154NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.53546189
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.53291253
156GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.52986593
157* TP53_20018659_ChIP-ChIP_R1E_Mouse0.52345563
158SOX2_22085726_ChIP-Seq_NPCs_Mouse0.51906441
159VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.51577529
160TAF2_19829295_ChIP-Seq_ESCs_Human0.51491946
161* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.48887446
162IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.48687286
163* CTCF_27219007_Chip-Seq_Bcells_Human0.48048878
164* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.47920501
165EZH2_27294783_Chip-Seq_ESCs_Mouse0.47817947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.73834610
2MP0005360_urolithiasis6.24176604
3MP0005365_abnormal_bile_salt5.76282776
4MP0005085_abnormal_gallbladder_physiolo5.66037573
5MP0008875_abnormal_xenobiotic_pharmacok4.45294651
6MP0003705_abnormal_hypodermis_morpholog4.07939940
7MP0003252_abnormal_bile_duct3.46043762
8MP0010234_abnormal_vibrissa_follicle3.38455338
9MP0010329_abnormal_lipoprotein_level3.31787654
10MP0003806_abnormal_nucleotide_metabolis3.11326277
11MP0005076_abnormal_cell_differentiation3.04659351
12MP0004858_abnormal_nervous_system2.76621295
13MP0005332_abnormal_amino_acid2.67158917
14MP0004185_abnormal_adipocyte_glucose2.66595708
15MP0003195_calcinosis2.52045909
16MP0005058_abnormal_lysosome_morphology2.49915679
17MP0000678_abnormal_parathyroid_gland2.25403891
18MP0005666_abnormal_adipose_tissue2.24513836
19MP0005083_abnormal_biliary_tract2.19513363
20MP0005646_abnormal_pituitary_gland2.13305629
21MP0005409_darkened_coat_color2.06825260
22MP0009697_abnormal_copulation2.06695196
23MP0001666_abnormal_nutrient_absorption2.04335074
24MP0001849_ear_inflammation1.96860252
25MP0009278_abnormal_bone_marrow1.96832762
26MP0001764_abnormal_homeostasis1.95518737
27MP0000751_myopathy1.89234610
28MP0009840_abnormal_foam_cell1.86527195
29MP0005319_abnormal_enzyme/_coenzyme1.82913433
30MP0003123_paternal_imprinting1.79669112
31MP0005670_abnormal_white_adipose1.79104197
32MP0001984_abnormal_olfaction1.77914435
33MP0002118_abnormal_lipid_homeostasis1.73431324
34MP0004233_abnormal_muscle_weight1.72850272
35MP0004264_abnormal_extraembryonic_tissu1.71834213
36MP0005584_abnormal_enzyme/coenzyme_acti1.71167950
37MP0006036_abnormal_mitochondrial_physio1.69186556
38MP0005375_adipose_tissue_phenotype1.66759529
39MP0001348_abnormal_lacrimal_gland1.66544086
40MP0003191_abnormal_cellular_cholesterol1.61883052
41MP0000537_abnormal_urethra_morphology1.61622152
42MP0000609_abnormal_liver_physiology1.61559762
43MP0000747_muscle_weakness1.55216023
44MP0010368_abnormal_lymphatic_system1.53300512
45MP0009672_abnormal_birth_weight1.49559057
46MP0004019_abnormal_vitamin_homeostasis1.48534043
47MP0000003_abnormal_adipose_tissue1.46202917
48MP0001730_embryonic_growth_arrest1.45223761
49MP0003646_muscle_fatigue1.45063605
50MP0003453_abnormal_keratinocyte_physiol1.42334511
51MP0000733_abnormal_muscle_development1.39735528
52MP0002877_abnormal_melanocyte_morpholog1.36683481
53MP0010630_abnormal_cardiac_muscle1.36462162
54MP0002166_altered_tumor_susceptibility1.36009680
55MP0008260_abnormal_autophagy1.32477705
56MP0003303_peritoneal_inflammation1.31808497
57MP0004087_abnormal_muscle_fiber1.29800655
58MP0002009_preneoplasia1.29666827
59MP0000759_abnormal_skeletal_muscle1.29620352
60MP0005647_abnormal_sex_gland1.28484543
61MP0003868_abnormal_feces_composition1.27914148
62MP0002822_catalepsy1.27263260
63MP0002796_impaired_skin_barrier1.26337258
64MP0005084_abnormal_gallbladder_morpholo1.20718582
65MP0005075_abnormal_melanosome_morpholog1.20180568
66MP0003111_abnormal_nucleus_morphology1.18263602
67MP0001873_stomach_inflammation1.18033505
68MP0003172_abnormal_lysosome_physiology1.17972340
69MP0003186_abnormal_redox_activity1.17785132
70MP0000598_abnormal_liver_morphology1.17481311
71MP0003091_abnormal_cell_migration1.16590456
72MP0003300_gastrointestinal_ulcer1.09873682
73MP0002837_dystrophic_cardiac_calcinosis1.09378065
74MP0005501_abnormal_skin_physiology1.09376414
75MP0000685_abnormal_immune_system1.09231556
76MP0005220_abnormal_exocrine_pancreas1.09206259
77MP0003566_abnormal_cell_adhesion1.09020239
78MP0000749_muscle_degeneration1.07544710
79MP0000681_abnormal_thyroid_gland1.04738848
80MP0004947_skin_inflammation1.04695591
81MP0005451_abnormal_body_composition1.04270478
82MP0000858_altered_metastatic_potential1.02753867
83MP0006035_abnormal_mitochondrial_morpho1.02168880
84MP0009384_cardiac_valve_regurgitation1.01704226
85MP0001346_abnormal_lacrimal_gland0.99717348
86MP0000350_abnormal_cell_proliferation0.98077762
87MP0004381_abnormal_hair_follicle0.96421484
88MP0002970_abnormal_white_adipose0.96047256
89MP0009333_abnormal_splenocyte_physiolog0.95782785
90MP0009643_abnormal_urine_homeostasis0.95729699
91MP0000490_abnormal_crypts_of0.95169049
92MP0002928_abnormal_bile_duct0.95103688
93MP0005535_abnormal_body_temperature0.94753514
94MP0002138_abnormal_hepatobiliary_system0.94636078
95MP0000477_abnormal_intestine_morphology0.94393278
96MP0002078_abnormal_glucose_homeostasis0.94376693
97MP0003763_abnormal_thymus_physiology0.93330023
98MP0005330_cardiomyopathy0.93131088
99MP0002080_prenatal_lethality0.92936852
100MP0009642_abnormal_blood_homeostasis0.88848172
101MP0002396_abnormal_hematopoietic_system0.88462708
102MP0009764_decreased_sensitivity_to0.88420376
103MP0003984_embryonic_growth_retardation0.88394823
104MP0003075_altered_response_to0.87705784
105MP0004130_abnormal_muscle_cell0.85783258
106MP0003943_abnormal_hepatobiliary_system0.85447981
107MP0003011_delayed_dark_adaptation0.84665531
108MP0004147_increased_porphyrin_level0.84406786
109MP0003693_abnormal_embryo_hatching0.84055472
110MP0003122_maternal_imprinting0.83792154
111MP0002876_abnormal_thyroid_physiology0.83324356
112MP0006138_congestive_heart_failure0.82973287
113MP0005376_homeostasis/metabolism_phenot0.82935048
114MP0005621_abnormal_cell_physiology0.81841371
115MP0002086_abnormal_extraembryonic_tissu0.81840103
116MP0004145_abnormal_muscle_electrophysio0.81707323
117MP0002249_abnormal_larynx_morphology0.80978809
118MP0000566_synostosis0.80933015
119MP0002971_abnormal_brown_adipose0.80686221
120MP0002088_abnormal_embryonic_growth/wei0.80402092
121MP0009931_abnormal_skin_appearance0.80201626
122MP0005266_abnormal_metabolism0.80177779
123MP0001545_abnormal_hematopoietic_system0.79721763
124MP0005397_hematopoietic_system_phenotyp0.79721763
125MP0000462_abnormal_digestive_system0.79668168
126MP0005636_abnormal_mineral_homeostasis0.79237756
127MP0003436_decreased_susceptibility_to0.79149450
128MP0005408_hypopigmentation0.78155771
129MP0001672_abnormal_embryogenesis/_devel0.77684897
130MP0005380_embryogenesis_phenotype0.77684897
131MP0010155_abnormal_intestine_physiology0.77522521
132MP0001502_abnormal_circadian_rhythm0.77350297
133MP0003077_abnormal_cell_cycle0.76343452
134MP0006292_abnormal_olfactory_placode0.75922946
135MP0000313_abnormal_cell_death0.75774251
136MP0002089_abnormal_postnatal_growth/wei0.75076783
137MP0001661_extended_life_span0.74182671
138MP0003942_abnormal_urinary_system0.72862106
139MP0004782_abnormal_surfactant_physiolog0.72578940
140MP0003690_abnormal_glial_cell0.71517691
141MP0004510_myositis0.70029492
142MP0002098_abnormal_vibrissa_morphology0.69894715
143MP0005464_abnormal_platelet_physiology0.69583959
144MP0000703_abnormal_thymus_morphology0.69519043
145MP0010352_gastrointestinal_tract_polyps0.69122363
146MP0009765_abnormal_xenobiotic_induced0.68404613
147MP0000467_abnormal_esophagus_morphology0.67651376
148MP0004036_abnormal_muscle_relaxation0.66940109
149MP0009053_abnormal_anal_canal0.66688203
150MP0003656_abnormal_erythrocyte_physiolo0.66049359
151MP0009763_increased_sensitivity_to0.65835473
152MP0003953_abnormal_hormone_level0.65727773
153MP0003879_abnormal_hair_cell0.65187606
154MP0004859_abnormal_synaptic_plasticity0.64628582
155MP0002269_muscular_atrophy0.64395246
156MP0002282_abnormal_trachea_morphology0.62764228
157MP0004085_abnormal_heartbeat0.62418663
158MP0004084_abnormal_cardiac_muscle0.62345959
159MP0004142_abnormal_muscle_tone0.59357872
160MP0000230_abnormal_systemic_arterial0.58276815
161MP0004808_abnormal_hematopoietic_stem0.57379182
162MP0008469_abnormal_protein_level0.55965228
163MP0005334_abnormal_fat_pad0.55301527
164MP0001944_abnormal_pancreas_morphology0.54919282
165MP0003115_abnormal_respiratory_system0.54410107
166MP0005551_abnormal_eye_electrophysiolog0.53071397
167MP0000639_abnormal_adrenal_gland0.52554189
168MP0001544_abnormal_cardiovascular_syste0.52139565
169MP0005385_cardiovascular_system_phenoty0.52139565
170MP0002132_abnormal_respiratory_system0.51255925
171MP0008872_abnormal_physiological_respon0.49165410
172MP0004043_abnormal_pH_regulation0.48890071
173MP0003638_abnormal_response/metabolism_0.48515739
174MP0009379_abnormal_foot_pigmentation0.48292495
175MP0002909_abnormal_adrenal_gland0.47641447
176MP0002653_abnormal_ependyma_morphology0.46040968
177MP0008995_early_reproductive_senescence0.45636494

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.31170866
2Intrahepatic cholestasis (HP:0001406)5.54041863
3Deep venous thrombosis (HP:0002625)5.38376764
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.33777176
5Hypobetalipoproteinemia (HP:0003563)4.96103473
6Prolonged partial thromboplastin time (HP:0003645)4.82650224
7Hyperlipoproteinemia (HP:0010980)4.41854716
8Xanthomatosis (HP:0000991)4.37555490
9Hyperammonemia (HP:0001987)4.25390281
10Hyperacusis (HP:0010780)4.19827556
11Ketosis (HP:0001946)4.16906276
12Hyperglycinemia (HP:0002154)4.10745687
13Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.93597600
14Hyperglycinuria (HP:0003108)3.90031577
15Hypoglycemic coma (HP:0001325)3.81736071
16Abnormality of fatty-acid metabolism (HP:0004359)3.76850307
17Abnormality of glycine metabolism (HP:0010895)3.63191660
18Abnormality of serine family amino acid metabolism (HP:0010894)3.63191660
19Hypolipoproteinemia (HP:0010981)3.53100897
20Complement deficiency (HP:0004431)3.47651507
21Centrally nucleated skeletal muscle fibers (HP:0003687)3.46104745
22Abnormality of pyrimidine metabolism (HP:0004353)3.42612616
23Hyperbilirubinemia (HP:0002904)3.40188655
24Fat malabsorption (HP:0002630)3.37400370
25Ketoacidosis (HP:0001993)3.32822806
26Joint hemorrhage (HP:0005261)3.31172464
27Myopathic facies (HP:0002058)3.27740265
28Exercise-induced myalgia (HP:0003738)3.27369277
29Obstructive sleep apnea (HP:0002870)3.21298284
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.20392368
31Generalized aminoaciduria (HP:0002909)3.18541852
32Abnormality of the common coagulation pathway (HP:0010990)3.17697595
33Broad face (HP:0000283)3.16632181
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.16200037
35Abnormality of the intrinsic pathway (HP:0010989)3.06865672
36Epidermoid cyst (HP:0200040)3.01426262
37Delayed CNS myelination (HP:0002188)2.96834444
38Hypoalphalipoproteinemia (HP:0003233)2.96251029
39Distal lower limb amyotrophy (HP:0008944)2.94697347
40Metabolic acidosis (HP:0001942)2.94303831
41Abnormality of aspartate family amino acid metabolism (HP:0010899)2.91205584
42Dicarboxylic aciduria (HP:0003215)2.89338244
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89338244
44Late onset (HP:0003584)2.87686674
45Hypercholesterolemia (HP:0003124)2.86519901
46Flat acetabular roof (HP:0003180)2.86154445
47Hemorrhage of the eye (HP:0011885)2.80155404
48Steatorrhea (HP:0002570)2.79870106
49Abnormality of sulfur amino acid metabolism (HP:0004339)2.79602082
50Abnormality of methionine metabolism (HP:0010901)2.78546666
51Increased connective tissue (HP:0009025)2.76736028
52Distal lower limb muscle weakness (HP:0009053)2.74665080
53Abnormality of serum amino acid levels (HP:0003112)2.74053060
54Myoglobinuria (HP:0002913)2.68076660
55Ragged-red muscle fibers (HP:0003200)2.65547193
56Gout (HP:0001997)2.64129854
57Brushfield spots (HP:0001088)2.63265840
58Reticulocytosis (HP:0001923)2.61414954
59Hypoglycemic seizures (HP:0002173)2.59900799
60Hepatocellular carcinoma (HP:0001402)2.59146499
61Achilles tendon contracture (HP:0001771)2.57636780
62Abnormality of nucleobase metabolism (HP:0010932)2.55740616
63Conjugated hyperbilirubinemia (HP:0002908)2.55593890
64Colitis (HP:0002583)2.52054133
65Cholecystitis (HP:0001082)2.50796788
66Abnormal gallbladder physiology (HP:0012438)2.50796788
67Abnormality of the fingertips (HP:0001211)2.48725727
68Abnormal biliary tract physiology (HP:0012439)2.44763156
69Bile duct proliferation (HP:0001408)2.44763156
70Abnormality of the Achilles tendon (HP:0005109)2.39661094
71Thin bony cortex (HP:0002753)2.39639263
72Insomnia (HP:0100785)2.39106106
73Ulnar bowing (HP:0003031)2.39101950
74Lethargy (HP:0001254)2.38928905
75Renal cortical cysts (HP:0000803)2.38153694
76Abnormality of the thoracic spine (HP:0100711)2.37144683
77Stridor (HP:0010307)2.36862443
78Germ cell neoplasia (HP:0100728)2.35859560
79Hyperthyroidism (HP:0000836)2.33181454
80Asymmetry of the thorax (HP:0001555)2.32607388
81Cellulitis (HP:0100658)2.32206852
82Hypoplasia of the thymus (HP:0000778)2.31835069
83Gastrointestinal stroma tumor (HP:0100723)2.31804089
84Truncus arteriosus (HP:0001660)2.30345210
85Increased muscle lipid content (HP:0009058)2.28689097
86Disproportionate tall stature (HP:0001519)2.27920177
87Easy fatigability (HP:0003388)2.26791622
88Cerebral aneurysm (HP:0004944)2.25825268
89Mildly elevated creatine phosphokinase (HP:0008180)2.25687100
90Neonatal onset (HP:0003623)2.25595159
91Cerebral edema (HP:0002181)2.24158430
92Spontaneous abortion (HP:0005268)2.23676386
93Long palpebral fissure (HP:0000637)2.23672927
94Increased variability in muscle fiber diameter (HP:0003557)2.22720623
95Abnormality of skeletal muscle fiber size (HP:0012084)2.22652340
96Upper limb amyotrophy (HP:0009129)2.22482762
97Distal upper limb amyotrophy (HP:0007149)2.22482762
98Abnormality of urine glucose concentration (HP:0011016)2.22072790
99Glycosuria (HP:0003076)2.22072790
100Enlarged kidneys (HP:0000105)2.20826498
101Dysmetric saccades (HP:0000641)2.20814856
102Cerebral palsy (HP:0100021)2.19035748
103Hyperparathyroidism (HP:0000843)2.18491724
104Abnormality of complement system (HP:0005339)2.13654888
105Bulbar palsy (HP:0001283)2.12891823
106Hepatic necrosis (HP:0002605)2.12751931
107Abnormality of purine metabolism (HP:0004352)2.12304616
108Gingival bleeding (HP:0000225)2.11175170
109Mitral stenosis (HP:0001718)2.09287134
110J-shaped sella turcica (HP:0002680)2.07920307
111Vomiting (HP:0002013)2.07400279
112Increased intramyocellular lipid droplets (HP:0012240)2.05979455
113Bowel incontinence (HP:0002607)2.03066508
114Hyperphosphaturia (HP:0003109)2.01132999
115Thoracic kyphosis (HP:0002942)2.00989674
116Cholelithiasis (HP:0001081)2.00747778
117Seborrheic dermatitis (HP:0001051)2.00333913
118Atelectasis (HP:0100750)2.00262558
119Abnormal gallbladder morphology (HP:0012437)2.00112163
120Proximal tubulopathy (HP:0000114)1.98490129
121Vertebral compression fractures (HP:0002953)1.98393692
122Thin ribs (HP:0000883)1.97511874
123Hypertensive crisis (HP:0100735)1.97281469
124Lipid accumulation in hepatocytes (HP:0006561)1.96404475
125Neoplasm of head and neck (HP:0012288)1.96339600
126Esophageal neoplasm (HP:0100751)1.96339600
127Metaphyseal cupping (HP:0003021)1.96331027
128Patellar dislocation (HP:0002999)1.96088485
129Abnormality of reticulocytes (HP:0004312)1.95820675
130Atrioventricular block (HP:0001678)1.95719058
131Limb hypertonia (HP:0002509)1.94659243
132Hypercortisolism (HP:0001578)1.94440810
133Status epilepticus (HP:0002133)1.94245983
134Exercise-induced muscle cramps (HP:0003710)1.93358910
135Thrombophlebitis (HP:0004418)1.88542014
136Ankyloglossia (HP:0010296)1.87661684
137Death in childhood (HP:0003819)1.87569545
138Skin nodule (HP:0200036)1.87391726
139Deep palmar crease (HP:0006191)1.87127052
140Lymphangioma (HP:0100764)1.86679003
141Lower limb amyotrophy (HP:0007210)1.86130194
142Severe visual impairment (HP:0001141)1.85064653
143Lactic acidosis (HP:0003128)1.84899720
144Elfin facies (HP:0004428)1.83255346
145Abnormal large intestine physiology (HP:0012700)1.83014046
146Progressive muscle weakness (HP:0003323)1.82756791
147Elevated hepatic transaminases (HP:0002910)1.82669253
148Protrusio acetabuli (HP:0003179)1.81914472
149Growth hormone excess (HP:0000845)1.81294031
150Malnutrition (HP:0004395)1.80638839
151Toxemia of pregnancy (HP:0100603)1.80493191
152Shallow orbits (HP:0000586)1.78257693
153Gastrointestinal inflammation (HP:0004386)1.77649748
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.77569028
155Overriding aorta (HP:0002623)1.77563391
156Hyperinsulinemic hypoglycemia (HP:0000825)1.75591968
157Neoplasm of the adrenal gland (HP:0100631)1.75433462
158Renal tubular dysfunction (HP:0000124)1.75122918
159Foot dorsiflexor weakness (HP:0009027)1.74069199
160Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73275375
161Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73275375
162Hyperventilation (HP:0002883)1.73262029
163Pointed chin (HP:0000307)1.72961438
164Precocious puberty (HP:0000826)1.72937948
165Acanthocytosis (HP:0001927)1.72368073
166Rhabdomyolysis (HP:0003201)1.71582712
167Spastic diplegia (HP:0001264)1.71466246
168Sparse lateral eyebrow (HP:0005338)1.70165760
169Asymmetric septal hypertrophy (HP:0001670)1.67498340
170Back pain (HP:0003418)1.65935374
171Flattened epiphyses (HP:0003071)1.65254078
172Cervical subluxation (HP:0003308)1.65041899
173Round ear (HP:0100830)1.64574779
174Polygenic inheritance (HP:0010982)1.64243744
175Abnormality of the tricuspid valve (HP:0001702)1.63696707
176Neonatal hypoglycemia (HP:0001998)1.63619306
177Septate vagina (HP:0001153)1.63573443
178Advanced eruption of teeth (HP:0006288)1.63066605
179Polycythemia (HP:0001901)1.63029155
180Turricephaly (HP:0000262)1.62148941
181Emphysema (HP:0002097)1.61009324
182Hypercalcemia (HP:0003072)1.60893448
183Agammaglobulinemia (HP:0004432)1.60851271
184Abdominal distention (HP:0003270)1.60131164
185Diaphragmatic weakness (HP:0009113)1.59570070
186Broad distal phalanx of finger (HP:0009836)1.59454341
187Macroorchidism (HP:0000053)1.59382483
188Abnormal ossification of hand bones (HP:0005921)1.58968785
189Biconcave vertebral bodies (HP:0004586)1.58752145
190Abnormality of the calcaneus (HP:0008364)1.57588888
191Abnormality of carpal bone ossification (HP:0006257)1.57486794
192Mitral regurgitation (HP:0001653)1.56851128
193Muscle stiffness (HP:0003552)1.56826956

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.57607186
2FLT34.25627056
3SMG13.78509459
4PKN23.39466744
5SIK13.30707958
6ERN13.07320983
7ICK2.98718618
8IRAK32.61781316
9MUSK2.52312952
10KIT2.44057007
11CDK122.27912097
12OBSCN1.92552716
13TRIB31.91821482
14EPHA21.91644851
15SGK21.84597530
16TNIK1.80891298
17CDK81.70985031
18PRKD31.66946888
19MYLK1.66488895
20TGFBR11.62939328
21PHKG11.60696411
22PHKG21.60696411
23TTN1.58470558
24CCNB11.53307455
25NTRK31.50954995
26INSRR1.46851610
27MAP3K71.43720509
28PINK11.43501720
29SIK31.42232189
30ZAK1.40932658
31MAP2K31.37279497
32PIK3CG1.37076128
33NME21.34397693
34FRK1.29782284
35NEK11.28060021
36BTK1.27612847
37MAP4K11.27458359
38SGK31.27275280
39MTOR1.25283049
40EEF2K1.25239056
41MAP2K61.22976932
42FGFR41.20757433
43TIE11.20359129
44MAPK111.20354910
45RIPK41.18826338
46MST1R1.16778335
47MARK21.16725946
48ERBB41.16156285
49TAOK21.14973756
50MAP3K101.13440292
51RPS6KB21.12485312
52YES11.09620365
53EPHA41.09370387
54MATK1.08670335
55SGK4941.08432331
56SGK2231.08432331
57STK161.06758065
58PRKD21.04061464
59CSF1R1.01174797
60KSR21.01020903
61MKNK10.99903328
62IRAK20.99558031
63TNK20.94126233
64MAP3K130.92839953
65PASK0.91980056
66TEC0.91958275
67NTRK20.90682174
68PDPK10.89123998
69IRAK40.88184028
70CAMK1D0.87373640
71PRKAA20.86980031
72DAPK20.85663541
73PDGFRA0.85562130
74CAMK10.85190283
75SCYL20.84448149
76MAP2K20.83557582
77MAP2K40.83235923
78LRRK20.82918845
79MAPK120.82780127
80DAPK10.82628661
81CDC42BPA0.81641628
82TAOK10.81455351
83ARAF0.81277230
84MAP3K10.81245947
85FGFR20.80248647
86TAOK30.79467871
87ERBB20.78606109
88MAP3K110.78334909
89AKT30.77916147
90HIPK20.77385410
91CDK70.76904842
92RIPK10.76524810
93AKT20.76520005
94RPS6KA20.75530844
95PAK40.74216006
96BRAF0.71014400
97CAMKK10.70177366
98FGFR30.68418270
99MAPK150.68230529
100CDK40.67907105
101PRPF4B0.66893729
102BRSK10.66173323
103MAP3K80.65931121
104CASK0.65322157
105PTK20.64689302
106MAPK40.62309995
107RPS6KB10.61776964
108MAP2K70.61343748
109RET0.60450649
110CHUK0.58562981
111DYRK1B0.58463437
112TBK10.58019593
113ADRBK20.56839716
114PIM20.54511584
115IKBKE0.54273323
116EPHB10.54119468
117PIK3CA0.53268350
118RPS6KA60.52856469
119TESK10.52852300
120RPS6KL10.52831556
121RPS6KC10.52831556
122MAPKAPK30.52483506
123CAMK40.52403361
124TESK20.51603094
125PDK10.50828818
126BMX0.50554868
127MAPK70.50067115
128CDK190.48772829
129TYRO30.48432504
130SYK0.47851455
131DMPK0.45717375
132PRKACG0.45347544
133TYK20.44168254
134PTK60.43977380
135CAMK1G0.43882583
136DDR20.42467175
137MAPK130.41956930
138CDK60.41771509
139LMTK20.41486573
140LATS20.41084101
141WNK30.40847314
142PRKCI0.40654788
143UHMK10.40599127
144MINK10.40472315
145STK40.40395693
146MKNK20.39334804
147MAP3K30.39079062
148NTRK10.37794279
149PRKCG0.36590641
150PRKG20.36554711
151PRKCZ0.35022301
152CDK90.33653154
153ILK0.33232626
154NME10.32740272
155JAK20.32501860
156MAP3K60.31818081
157PRKAA10.31629624
158RPS6KA10.31552219
159MAP3K90.29737909
160MAPK30.29249066
161MAPKAPK20.29247172
162SIK20.28629769
163BRD40.28118649
164MAP3K20.27609179
165RAF10.27037211
166CDK20.26380926
167MET0.26316467

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.26183748
2Nitrogen metabolism_Homo sapiens_hsa009103.51115564
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.12341900
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.02081924
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.84895651
6Fatty acid degradation_Homo sapiens_hsa000712.79062038
7Arginine biosynthesis_Homo sapiens_hsa002202.73838918
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71216600
9Other glycan degradation_Homo sapiens_hsa005112.45759965
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.43968957
11Tryptophan metabolism_Homo sapiens_hsa003802.40333280
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34163618
13Peroxisome_Homo sapiens_hsa041462.33797648
14Notch signaling pathway_Homo sapiens_hsa043302.29586877
15Chronic myeloid leukemia_Homo sapiens_hsa052202.21548102
16Propanoate metabolism_Homo sapiens_hsa006402.21169333
17Acute myeloid leukemia_Homo sapiens_hsa052212.18971394
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17615688
19Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07720406
20Complement and coagulation cascades_Homo sapiens_hsa046102.07021429
21Non-small cell lung cancer_Homo sapiens_hsa052232.03712874
22Butanoate metabolism_Homo sapiens_hsa006502.00222813
23Fatty acid metabolism_Homo sapiens_hsa012121.95963230
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95574349
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89052887
26Selenocompound metabolism_Homo sapiens_hsa004501.81251076
27PPAR signaling pathway_Homo sapiens_hsa033201.79846454
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.79066088
29B cell receptor signaling pathway_Homo sapiens_hsa046621.78859649
30Biosynthesis of amino acids_Homo sapiens_hsa012301.75027071
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.73602351
32Carbon metabolism_Homo sapiens_hsa012001.72228102
33Pyruvate metabolism_Homo sapiens_hsa006201.70488248
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.69655882
35Thyroid cancer_Homo sapiens_hsa052161.64824825
36VEGF signaling pathway_Homo sapiens_hsa043701.61950405
37Endometrial cancer_Homo sapiens_hsa052131.59112144
38beta-Alanine metabolism_Homo sapiens_hsa004101.58268560
39Bladder cancer_Homo sapiens_hsa052191.58046180
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.56332813
41Starch and sucrose metabolism_Homo sapiens_hsa005001.54623473
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50966238
43Chemical carcinogenesis_Homo sapiens_hsa052041.44938705
44Pancreatic cancer_Homo sapiens_hsa052121.43536643
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.41835754
46Phenylalanine metabolism_Homo sapiens_hsa003601.38057121
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35833695
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35830795
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35594055
50Bile secretion_Homo sapiens_hsa049761.35410057
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34555846
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34097591
53Cyanoamino acid metabolism_Homo sapiens_hsa004601.34004564
54mTOR signaling pathway_Homo sapiens_hsa041501.27677574
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27521225
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.26471433
57Histidine metabolism_Homo sapiens_hsa003401.22403123
58Glioma_Homo sapiens_hsa052141.21487479
59Tyrosine metabolism_Homo sapiens_hsa003501.19398952
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.19000058
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16204217
62Fatty acid elongation_Homo sapiens_hsa000621.15109059
63Renal cell carcinoma_Homo sapiens_hsa052111.14182062
64Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13873541
65ErbB signaling pathway_Homo sapiens_hsa040121.10977364
66Retinol metabolism_Homo sapiens_hsa008301.10795623
67One carbon pool by folate_Homo sapiens_hsa006701.10699453
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09438381
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06233006
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04409397
71Prostate cancer_Homo sapiens_hsa052151.04392169
72Galactose metabolism_Homo sapiens_hsa000521.03889075
73ABC transporters_Homo sapiens_hsa020101.03488688
74Folate biosynthesis_Homo sapiens_hsa007901.02588363
75Caffeine metabolism_Homo sapiens_hsa002320.99185953
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.98253079
77Pentose phosphate pathway_Homo sapiens_hsa000300.97461388
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96756675
79Hepatitis C_Homo sapiens_hsa051600.95361309
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94051316
81Choline metabolism in cancer_Homo sapiens_hsa052310.92995314
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87725174
83GnRH signaling pathway_Homo sapiens_hsa049120.87051055
84Fatty acid biosynthesis_Homo sapiens_hsa000610.86719611
85Estrogen signaling pathway_Homo sapiens_hsa049150.86111007
86Lysine degradation_Homo sapiens_hsa003100.83454954
87Small cell lung cancer_Homo sapiens_hsa052220.82295404
88Colorectal cancer_Homo sapiens_hsa052100.82116585
89Sulfur relay system_Homo sapiens_hsa041220.81386198
90Sulfur metabolism_Homo sapiens_hsa009200.81253727
91Prolactin signaling pathway_Homo sapiens_hsa049170.79928278
92Hepatitis B_Homo sapiens_hsa051610.79924100
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79822245
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.79463138
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78621312
96Staphylococcus aureus infection_Homo sapiens_hsa051500.75307028
97Arginine and proline metabolism_Homo sapiens_hsa003300.74321688
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73378984
99Inositol phosphate metabolism_Homo sapiens_hsa005620.72974284
100Influenza A_Homo sapiens_hsa051640.71913518
101HTLV-I infection_Homo sapiens_hsa051660.70439569
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68272229
103HIF-1 signaling pathway_Homo sapiens_hsa040660.67706961
104Fructose and mannose metabolism_Homo sapiens_hsa000510.66223012
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65238114
106MicroRNAs in cancer_Homo sapiens_hsa052060.64945629
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.64602708
108Apoptosis_Homo sapiens_hsa042100.63995206
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63427263
110Viral carcinogenesis_Homo sapiens_hsa052030.59866324
111Fat digestion and absorption_Homo sapiens_hsa049750.56190724
112Metabolic pathways_Homo sapiens_hsa011000.55495176
113Focal adhesion_Homo sapiens_hsa045100.54733712
114mRNA surveillance pathway_Homo sapiens_hsa030150.54261360
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.52891661
116Glycerolipid metabolism_Homo sapiens_hsa005610.51674003
117Long-term potentiation_Homo sapiens_hsa047200.51323358
118Thyroid hormone synthesis_Homo sapiens_hsa049180.49376761
119Vitamin B6 metabolism_Homo sapiens_hsa007500.48228283
120Glucagon signaling pathway_Homo sapiens_hsa049220.47845709
121Herpes simplex infection_Homo sapiens_hsa051680.47424512
122Leishmaniasis_Homo sapiens_hsa051400.47341153
123Toxoplasmosis_Homo sapiens_hsa051450.46855204
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46478295
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44777138
126Proteoglycans in cancer_Homo sapiens_hsa052050.44499582
127Epstein-Barr virus infection_Homo sapiens_hsa051690.44224376
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.42745141
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.42661531
130Viral myocarditis_Homo sapiens_hsa054160.41370429
131Glutathione metabolism_Homo sapiens_hsa004800.39906641
132Melanogenesis_Homo sapiens_hsa049160.39209557
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.37680455
134Vibrio cholerae infection_Homo sapiens_hsa051100.36486643
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34436180
136Vitamin digestion and absorption_Homo sapiens_hsa049770.31691679
137Cardiac muscle contraction_Homo sapiens_hsa042600.30166004
138Insulin resistance_Homo sapiens_hsa049310.29519518
139N-Glycan biosynthesis_Homo sapiens_hsa005100.22411335
140DNA replication_Homo sapiens_hsa030300.21941132
141Olfactory transduction_Homo sapiens_hsa047400.20590861
142Pyrimidine metabolism_Homo sapiens_hsa002400.18956362
143Steroid biosynthesis_Homo sapiens_hsa001000.16152078
144Insulin signaling pathway_Homo sapiens_hsa049100.14635673
145Carbohydrate digestion and absorption_Homo sapiens_hsa049730.14568276
146GABAergic synapse_Homo sapiens_hsa047270.11707159
147AMPK signaling pathway_Homo sapiens_hsa041520.07442089
148Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06244344
149Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03936732
150Prion diseases_Homo sapiens_hsa050200.03766466
151Glycosaminoglycan degradation_Homo sapiens_hsa005310.03154057
152Purine metabolism_Homo sapiens_hsa002300.03098888
153Parkinsons disease_Homo sapiens_hsa050120.02627537
154Circadian rhythm_Homo sapiens_hsa047100.02410918
155Nicotine addiction_Homo sapiens_hsa050330.01359058
156Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01229464
157Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0509052
158Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.0465699
159Circadian entrainment_Homo sapiens_hsa04713-0.0370196
160Base excision repair_Homo sapiens_hsa03410-0.0342984
161Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0179174
162Cocaine addiction_Homo sapiens_hsa05030-0.0178605

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