RERE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)3.73178838
2cytoskeletal anchoring at plasma membrane (GO:0007016)3.70525907
3positive regulation of histone deacetylation (GO:0031065)3.61508177
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.52240489
5cytoplasmic mRNA processing body assembly (GO:0033962)3.48820481
6regulation of NFAT protein import into nucleus (GO:0051532)3.39410391
7pre-miRNA processing (GO:0031054)3.39294825
8glucocorticoid receptor signaling pathway (GO:0042921)3.34361658
9sodium ion export (GO:0071436)3.31659519
10insulin-like growth factor receptor signaling pathway (GO:0048009)3.30609990
11cerebellar granule cell differentiation (GO:0021707)3.30222978
12regulation of ARF protein signal transduction (GO:0032012)3.02444827
13peptidyl-lysine dimethylation (GO:0018027)3.02074706
14locomotory exploration behavior (GO:0035641)2.99522787
15cell-cell junction maintenance (GO:0045217)2.98467395
16stress granule assembly (GO:0034063)2.95767254
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.94522585
18histone H3-K4 trimethylation (GO:0080182)2.91045185
19positive regulation of gene expression, epigenetic (GO:0045815)2.89935812
20negative regulation of cell size (GO:0045792)2.89718527
21histone H3-K4 methylation (GO:0051568)2.86878511
22receptor catabolic process (GO:0032801)2.84421462
23histone H3-K36 demethylation (GO:0070544)2.80858999
24retrograde transport, vesicle recycling within Golgi (GO:0000301)2.73423131
25positive regulation of Rap GTPase activity (GO:0032854)2.71135898
26cerebellar Purkinje cell differentiation (GO:0021702)2.68583718
27negative regulation of erythrocyte differentiation (GO:0045647)2.68247478
28establishment of nucleus localization (GO:0040023)2.66258888
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.65988214
30synaptic vesicle endocytosis (GO:0048488)2.65367654
31membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.63601128
32positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.63510821
33protein targeting to Golgi (GO:0000042)2.63394039
34histone lysine demethylation (GO:0070076)2.62067029
35regulation of ARF GTPase activity (GO:0032312)2.59865505
36camera-type eye morphogenesis (GO:0048593)2.59697971
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59072455
38synaptic vesicle maturation (GO:0016188)2.57160696
39intracellular estrogen receptor signaling pathway (GO:0030520)2.56798426
40cellular response to monoamine stimulus (GO:0071868)2.56723478
41cellular response to catecholamine stimulus (GO:0071870)2.56723478
42neuronal ion channel clustering (GO:0045161)2.56473590
43plasma membrane repair (GO:0001778)2.54981422
44mannose metabolic process (GO:0006013)2.54696917
45corticosteroid receptor signaling pathway (GO:0031958)2.54060578
46cell communication by electrical coupling (GO:0010644)2.51713421
47establishment of protein localization to Golgi (GO:0072600)2.50734698
48regulation of synaptic vesicle exocytosis (GO:2000300)2.49458414
49cell junction maintenance (GO:0034331)2.49032690
50potassium ion import (GO:0010107)2.49007406
51peptidyl-threonine phosphorylation (GO:0018107)2.48710718
52peptidyl-tyrosine autophosphorylation (GO:0038083)2.47968512
53histone lysine methylation (GO:0034968)2.46652357
54histone demethylation (GO:0016577)2.45977883
55heart morphogenesis (GO:0003007)2.45756969
56regulation of short-term neuronal synaptic plasticity (GO:0048172)2.45665583
57cellular potassium ion homeostasis (GO:0030007)2.45079329
58peptidyl-threonine modification (GO:0018210)2.45010150
59regulation of clathrin-mediated endocytosis (GO:2000369)2.43506096
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.43246742
61neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.42974124
62cortical actin cytoskeleton organization (GO:0030866)2.41718119
63cardiac myofibril assembly (GO:0055003)2.41645904
64activation of protein kinase A activity (GO:0034199)2.41643219
65vocalization behavior (GO:0071625)2.40666827
66gastrulation with mouth forming second (GO:0001702)2.38901443
67G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.38898720
68negative regulation of inclusion body assembly (GO:0090084)2.38309334
69regulation of Rap GTPase activity (GO:0032317)2.37167262
70establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35912886
71dendritic spine morphogenesis (GO:0060997)2.35753352
72membrane repolarization during action potential (GO:0086011)2.35429303
73histone H4-K16 acetylation (GO:0043984)2.34817291
74dendrite morphogenesis (GO:0048813)2.33931800
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.33893193
76endothelial cell chemotaxis (GO:0035767)2.33769088
77peripheral nervous system axon ensheathment (GO:0032292)2.32576026
78myelination in peripheral nervous system (GO:0022011)2.32576026
79cell migration in hindbrain (GO:0021535)2.29280269
80negative regulation of nucleotide catabolic process (GO:0030812)2.29128754
81regulation of synapse maturation (GO:0090128)2.28998451
82positive regulation of CREB transcription factor activity (GO:0032793)2.28438692
83positive regulation of RNA splicing (GO:0033120)2.27694409
84negative regulation of myotube differentiation (GO:0010832)2.26631358
85negative regulation of catenin import into nucleus (GO:0035414)2.26597343
86regulation of p38MAPK cascade (GO:1900744)2.25975079
87glial cell proliferation (GO:0014009)2.25974875
88polarized epithelial cell differentiation (GO:0030859)2.25958097
89embryonic foregut morphogenesis (GO:0048617)2.25570524
90protein-DNA complex disassembly (GO:0032986)2.25081693
91nucleosome disassembly (GO:0006337)2.25081693
92hippo signaling (GO:0035329)2.23754407
93myofibril assembly (GO:0030239)2.23641670
94cellular response to epinephrine stimulus (GO:0071872)2.22847429
95protein localization to endosome (GO:0036010)2.22613419
96COPI coating of Golgi vesicle (GO:0048205)2.22600316
97Golgi transport vesicle coating (GO:0048200)2.22600316
98regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.21851052
99positive regulation of protein deacetylation (GO:0090312)2.21120960
100positive regulation of nuclease activity (GO:0032075)2.20529371
101focal adhesion assembly (GO:0048041)2.20434872
102cell-substrate adherens junction assembly (GO:0007045)2.20434872
103activation of JUN kinase activity (GO:0007257)2.19695954
104planar cell polarity pathway involved in neural tube closure (GO:0090179)2.19187700
105positive regulation of glycogen biosynthetic process (GO:0045725)2.17498253
106membrane repolarization (GO:0086009)2.17305909
107negative regulation of fatty acid transport (GO:2000192)2.17030983
108response to catecholamine (GO:0071869)2.16835841
109response to monoamine (GO:0071867)2.16835841
110antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.16282145
111cardiac muscle hypertrophy in response to stress (GO:0014898)2.16169999
112muscle hypertrophy in response to stress (GO:0003299)2.16169999
113cardiac muscle adaptation (GO:0014887)2.16169999
114growth hormone secretion (GO:0030252)2.15914944
115coronary vasculature morphogenesis (GO:0060977)2.15692258
116embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15138052
117adherens junction assembly (GO:0034333)2.14212984
118cerebellar Purkinje cell layer development (GO:0021680)2.13763264
119negative regulation of Ras protein signal transduction (GO:0046580)2.13524813
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.13389409
121negative regulation of histone methylation (GO:0031061)2.13154783
122negative regulation of GTP catabolic process (GO:0033125)2.13061097
123negative regulation of GTPase activity (GO:0034260)2.13061097
124chromatin silencing (GO:0006342)2.12964828
125epithelial cell fate commitment (GO:0072148)2.12835611
126histone H4-K12 acetylation (GO:0043983)2.12330508
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.12180337
128synaptic vesicle exocytosis (GO:0016079)2.12152421
129semaphorin-plexin signaling pathway (GO:0071526)2.11646411
130synaptic vesicle docking involved in exocytosis (GO:0016081)2.11476913
131regulation of somitogenesis (GO:0014807)2.10843953
132heterochromatin organization (GO:0070828)2.10775862
133regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.10714529
134head development (GO:0060322)2.10112413
135neuromuscular process controlling balance (GO:0050885)2.09838886
136stress fiber assembly (GO:0043149)2.09328109
137regulation of T-helper 2 cell differentiation (GO:0045628)2.09324186
138cell differentiation in hindbrain (GO:0021533)2.09249919
139regulation of histone deacetylation (GO:0031063)2.08999851
140nucleus localization (GO:0051647)2.08653795
141embryonic camera-type eye morphogenesis (GO:0048596)2.08489602
142histone H3-K9 demethylation (GO:0033169)2.08371233
143protein demethylation (GO:0006482)2.07287271
144protein dealkylation (GO:0008214)2.07287271
145negative regulation of small GTPase mediated signal transduction (GO:0051058)2.06885038
146negative regulation of Rho protein signal transduction (GO:0035024)2.06151949
147regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.04908673
148mitotic sister chromatid cohesion (GO:0007064)2.04661598
149neurotransmitter-gated ion channel clustering (GO:0072578)2.04191668
150regulation of glutamate receptor signaling pathway (GO:1900449)2.03643144
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.03458140
152innervation (GO:0060384)2.03068405
153negative regulation of purine nucleotide catabolic process (GO:0033122)2.02877027
154positive regulation of synapse maturation (GO:0090129)2.02414047
155postsynaptic membrane organization (GO:0001941)2.02133703
156dopamine receptor signaling pathway (GO:0007212)2.00982517
157regulation of synaptic vesicle transport (GO:1902803)2.00426182
158receptor recycling (GO:0001881)1.99632625
159cell communication involved in cardiac conduction (GO:0086065)1.97974249
160cardiac muscle hypertrophy (GO:0003300)1.97938850
161cranial nerve morphogenesis (GO:0021602)1.97910392
162L-amino acid import (GO:0043092)1.97288873
163histone H3-K9 modification (GO:0061647)1.96080716

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.20378152
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.03465694
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.82422249
4MYC_22102868_ChIP-Seq_BL_Human2.82277172
5* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.59255459
6EZH2_22144423_ChIP-Seq_EOC_Human2.48416288
7* KDM2B_26808549_Chip-Seq_DND41_Human2.46668219
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.39239293
9* KDM2B_26808549_Chip-Seq_K562_Human2.28181494
10WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.26599029
11DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.23832703
12DROSHA_22980978_ChIP-Seq_HELA_Human2.20380500
13ZFP281_27345836_Chip-Seq_ESCs_Mouse2.19562197
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.19004125
15TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.12405605
16* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.11953770
17SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.11886817
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.05109564
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00156598
20* KDM2B_26808549_Chip-Seq_JURKAT_Human1.99948571
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.99589022
22* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95112053
23* RARB_27405468_Chip-Seq_BRAIN_Mouse1.81169133
24VDR_21846776_ChIP-Seq_THP-1_Human1.79101004
25* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.70907747
26LXR_22292898_ChIP-Seq_THP-1_Human1.68173933
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66501332
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60345780
29* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.55599792
30* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.54882494
31GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52436799
32* ISL1_27105846_Chip-Seq_CPCs_Mouse1.50794478
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.50329538
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.49781519
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.47977735
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44671012
37* CREB1_26743006_Chip-Seq_LNCaP_Human1.42210484
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.41176325
39RNF2_18974828_ChIP-Seq_MESCs_Mouse1.41176325
40* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.40553407
41* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40183642
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39922330
43DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37145084
44SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35737347
45CTCF_27219007_Chip-Seq_Bcells_Human1.33386148
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.32445637
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31459587
48ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30347314
49* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30251548
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.29961820
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.29520026
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29034919
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.28774285
54* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.27438803
55RACK7_27058665_Chip-Seq_MCF-7_Human1.27298483
56* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.27182109
57* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27154092
58* SPI1_23127762_ChIP-Seq_K562_Human1.26459585
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24910217
60SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24440839
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22201335
62TBX20_22080862_ChIP-Seq_HEART_Mouse1.22142148
63TBX20_22328084_ChIP-Seq_HEART_Mouse1.22142148
64FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.20461503
65AHR_22903824_ChIP-Seq_MCF-7_Human1.20371498
66AR_21572438_ChIP-Seq_LNCaP_Human1.20028938
67TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.19175072
68* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18163657
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18084168
70PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17409526
71CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16569363
72EED_16625203_ChIP-ChIP_MESCs_Mouse1.14701717
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12533132
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.12474238
75CIITA_25753668_ChIP-Seq_RAJI_Human1.10917395
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10732326
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09815257
78* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09239501
79* AR_19668381_ChIP-Seq_PC3_Human1.08842157
80* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08665040
81* UTX_26944678_Chip-Seq_JUKART_Human1.08291336
82* RING1B_27294783_Chip-Seq_NPCs_Mouse1.08091588
83SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.07908535
84* GATA1_19941826_ChIP-Seq_K562_Human1.07782537
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07212161
86* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06900720
87* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06542091
88GATA1_19941827_ChIP-Seq_MEL_Mouse1.05789305
89NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.05514017
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.05199142
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.04283907
92THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04058955
93FOXM1_23109430_ChIP-Seq_U2OS_Human1.03331220
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.03142879
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01794666
96* FOXA2_19822575_ChIP-Seq_HepG2_Human1.01787827
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01638150
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99659466
99EZH2_27294783_Chip-Seq_ESCs_Mouse0.99201666
100RING1B_27294783_Chip-Seq_ESCs_Mouse0.98866497
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98603818
102SMC4_20622854_ChIP-Seq_HELA_Human0.97753692
103OCT4_19829295_ChIP-Seq_ESCs_Human0.97395738
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97214312
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96355751
106NCOR1_26117541_ChIP-Seq_K562_Human0.96320225
107* SA1_27219007_Chip-Seq_ERYTHROID_Human0.95953555
108REST_21632747_ChIP-Seq_MESCs_Mouse0.94501893
109CLOCK_20551151_ChIP-Seq_293T_Human0.94070979
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.92821764
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92708741
112* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92674673
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92504547
114CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91628891
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91611818
116P68_20966046_ChIP-Seq_HELA_Human0.90773457
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90157204
118VDR_24763502_ChIP-Seq_THP-1_Human0.88093382
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.87754620
120* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87707429
121REST_18959480_ChIP-ChIP_MESCs_Mouse0.85885634
122* TP53_23651856_ChIP-Seq_MEFs_Mouse0.85557018
123* TP63_22573176_ChIP-Seq_HFKS_Human0.85547826
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.85058674
125KLF4_19829295_ChIP-Seq_ESCs_Human0.84039786

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.23470480
2MP0008961_abnormal_basal_metabolism3.16716694
3MP0003283_abnormal_digestive_organ3.01655535
4MP0000569_abnormal_digit_pigmentation2.81081837
5MP0005076_abnormal_cell_differentiation2.71395374
6MP0005409_darkened_coat_color2.56980449
7MP0003705_abnormal_hypodermis_morpholog2.48188854
8MP0003122_maternal_imprinting2.40916399
9MP0002249_abnormal_larynx_morphology2.28259028
10MP0009780_abnormal_chondrocyte_physiolo2.19904841
11MP0002909_abnormal_adrenal_gland2.19803475
12MP0003300_gastrointestinal_ulcer2.15697912
13MP0005423_abnormal_somatic_nervous2.15182329
14MP0002822_catalepsy2.12947046
15MP0003879_abnormal_hair_cell2.08278701
16MP0004233_abnormal_muscle_weight2.01748664
17MP0001348_abnormal_lacrimal_gland2.00744297
18MP0000003_abnormal_adipose_tissue1.97624457
19MP0005377_hearing/vestibular/ear_phenot1.93900071
20MP0003878_abnormal_ear_physiology1.93900071
21MP0002653_abnormal_ependyma_morphology1.87110791
22MP0003045_fibrosis1.86455922
23MP0005670_abnormal_white_adipose1.84772052
24MP0003787_abnormal_imprinting1.82010857
25MP0004510_myositis1.81660499
26MP0004270_analgesia1.76414124
27MP0005623_abnormal_meninges_morphology1.75114684
28MP0001849_ear_inflammation1.71329323
29MP0000751_myopathy1.62982828
30MP0000566_synostosis1.61653747
31MP0009278_abnormal_bone_marrow1.61102157
32MP0000013_abnormal_adipose_tissue1.60106283
33MP0005375_adipose_tissue_phenotype1.54743974
34MP0004145_abnormal_muscle_electrophysio1.52935784
35MP0000733_abnormal_muscle_development1.52856310
36MP0004264_abnormal_extraembryonic_tissu1.52792245
37MP0010234_abnormal_vibrissa_follicle1.52180777
38MP0002735_abnormal_chemical_nociception1.51187363
39MP0004185_abnormal_adipocyte_glucose1.49092549
40MP0006138_congestive_heart_failure1.48553468
41MP0003121_genomic_imprinting1.46324315
42MP0002234_abnormal_pharynx_morphology1.40527563
43MP0010352_gastrointestinal_tract_polyps1.38738896
44MP0001486_abnormal_startle_reflex1.37416046
45MP0004858_abnormal_nervous_system1.37358970
46MP0000537_abnormal_urethra_morphology1.36191056
47MP0001958_emphysema1.34633593
48MP0004885_abnormal_endolymph1.34344691
49MP0003890_abnormal_embryonic-extraembry1.34237413
50MP0003635_abnormal_synaptic_transmissio1.33882340
51MP0002734_abnormal_mechanical_nocicepti1.33265302
52MP0002108_abnormal_muscle_morphology1.31513489
53MP0003172_abnormal_lysosome_physiology1.31019867
54MP0002877_abnormal_melanocyte_morpholog1.30324728
55MP0003183_abnormal_peptide_metabolism1.29900750
56MP0003329_amyloid_beta_deposits1.28315377
57MP0003119_abnormal_digestive_system1.26239763
58MP0003115_abnormal_respiratory_system1.24980080
59MP0005666_abnormal_adipose_tissue1.23949078
60MP0001502_abnormal_circadian_rhythm1.23673761
61MP0002064_seizures1.23532560
62MP0003690_abnormal_glial_cell1.23521197
63MP0008569_lethality_at_weaning1.23420284
64MP0004087_abnormal_muscle_fiber1.21246370
65MP0010630_abnormal_cardiac_muscle1.19755800
66MP0001501_abnormal_sleep_pattern1.19610230
67MP0002837_dystrophic_cardiac_calcinosis1.18033430
68MP0003566_abnormal_cell_adhesion1.17397139
69MP0003279_aneurysm1.12966576
70MP0002009_preneoplasia1.10782416
71MP0001299_abnormal_eye_distance/1.09687862
72MP0002572_abnormal_emotion/affect_behav1.09258529
73MP0005451_abnormal_body_composition1.08670529
74MP0002084_abnormal_developmental_patter1.08120441
75MP0010368_abnormal_lymphatic_system1.05806212
76* MP0002925_abnormal_cardiovascular_devel1.05456548
77MP0009672_abnormal_birth_weight1.05007968
78MP0003091_abnormal_cell_migration1.04940546
79MP0000534_abnormal_ureter_morphology1.04195029
80MP0005187_abnormal_penis_morphology1.04099708
81MP0001944_abnormal_pancreas_morphology1.03707367
82MP0003828_pulmonary_edema1.03563744
83MP0009703_decreased_birth_body1.03242045
84MP0002733_abnormal_thermal_nociception1.01198075
85* MP0003935_abnormal_craniofacial_develop0.99674769
86MP0003303_peritoneal_inflammation0.99443701
87MP0000462_abnormal_digestive_system0.98365912
88MP0000759_abnormal_skeletal_muscle0.97380546
89MP0005503_abnormal_tendon_morphology0.97272574
90MP0004197_abnormal_fetal_growth/weight/0.97184726
91MP0004130_abnormal_muscle_cell0.96613003
92MP0000428_abnormal_craniofacial_morphol0.96269778
93MP0000747_muscle_weakness0.96246860
94MP0002127_abnormal_cardiovascular_syste0.95670891
95MP0002557_abnormal_social/conspecific_i0.95491632
96* MP0000266_abnormal_heart_morphology0.92072556
97MP0002896_abnormal_bone_mineralization0.90905322
98MP0005369_muscle_phenotype0.90780183
99MP0009115_abnormal_fat_cell0.90444332
100MP0002928_abnormal_bile_duct0.90441504
101MP0004272_abnormal_basement_membrane0.88609559
102MP0000955_abnormal_spinal_cord0.87765953
103MP0009745_abnormal_behavioral_response0.87318581
104MP0003938_abnormal_ear_development0.87196776
105MP0001970_abnormal_pain_threshold0.85612793
106MP0005645_abnormal_hypothalamus_physiol0.85361501
107* MP0003861_abnormal_nervous_system0.85232015
108MP0002089_abnormal_postnatal_growth/wei0.85197773
109MP0002067_abnormal_sensory_capabilities0.84936770
110MP0003123_paternal_imprinting0.84921701
111MP0004811_abnormal_neuron_physiology0.84702779
112MP0001784_abnormal_fluid_regulation0.83650182
113MP0002882_abnormal_neuron_morphology0.83621666
114MP0002272_abnormal_nervous_system0.83528456
115MP0003634_abnormal_glial_cell0.82965535
116MP0006054_spinal_hemorrhage0.82705373
117MP0002971_abnormal_brown_adipose0.82587929
118MP0003385_abnormal_body_wall0.82257574
119MP0000767_abnormal_smooth_muscle0.81847685
120MP0000778_abnormal_nervous_system0.81340669
121MP0002063_abnormal_learning/memory/cond0.80898306
122MP0004043_abnormal_pH_regulation0.80379560
123MP0010030_abnormal_orbit_morphology0.79493490
124MP0004084_abnormal_cardiac_muscle0.79321200
125MP0005620_abnormal_muscle_contractility0.79215957
126MP0002116_abnormal_craniofacial_bone0.78618654
127MP0003948_abnormal_gas_homeostasis0.77878939
128MP0002932_abnormal_joint_morphology0.77417150
129MP0001879_abnormal_lymphatic_vessel0.77277643
130* MP0002085_abnormal_embryonic_tissue0.77273785
131MP0001440_abnormal_grooming_behavior0.77096214
132* MP0002152_abnormal_brain_morphology0.76452566
133MP0002269_muscular_atrophy0.76434553
134MP0003984_embryonic_growth_retardation0.75200671
135MP0002088_abnormal_embryonic_growth/wei0.74058192
136MP0003942_abnormal_urinary_system0.72803063
137MP0008770_decreased_survivor_rate0.70833104
138MP0004484_altered_response_of0.70204139
139MP0002697_abnormal_eye_size0.70142869
140MP0002106_abnormal_muscle_physiology0.68814948
141MP0002086_abnormal_extraembryonic_tissu0.67937557
142MP0004036_abnormal_muscle_relaxation0.67205201
143MP0000678_abnormal_parathyroid_gland0.66680693
144MP0004808_abnormal_hematopoietic_stem0.66026119
145MP0001730_embryonic_growth_arrest0.65742939
146MP0006072_abnormal_retinal_apoptosis0.64924626
147MP0001672_abnormal_embryogenesis/_devel0.64894095

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.76529379
2Macroorchidism (HP:0000053)3.66005018
3Cerebral aneurysm (HP:0004944)3.63077717
4Hyperacusis (HP:0010780)3.46710065
5Shallow orbits (HP:0000586)2.92935928
6Abnormality of the fingertips (HP:0001211)2.91804962
7Elfin facies (HP:0004428)2.74839898
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.74827476
9Renal duplication (HP:0000075)2.69663533
10Neoplasm of the heart (HP:0100544)2.69075846
11Myokymia (HP:0002411)2.61143812
12Vertebral arch anomaly (HP:0008438)2.58042756
13Broad face (HP:0000283)2.55814899
14Insomnia (HP:0100785)2.53908218
15Long eyelashes (HP:0000527)2.52977992
16Abnormality of the aortic arch (HP:0012303)2.49921288
17Difficulty running (HP:0009046)2.44507666
18Genetic anticipation (HP:0003743)2.38457856
19Progressive cerebellar ataxia (HP:0002073)2.36034979
20Broad metatarsal (HP:0001783)2.34423138
21Asymmetric septal hypertrophy (HP:0001670)2.31116469
22Enlarged penis (HP:0000040)2.28619065
23Urethral obstruction (HP:0000796)2.27505353
24Short 4th metacarpal (HP:0010044)2.26223277
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26223277
26Obsessive-compulsive behavior (HP:0000722)2.26098222
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.24287748
28Abnormality of the ischium (HP:0003174)2.23563792
29Increased variability in muscle fiber diameter (HP:0003557)2.23141154
30Narrow palate (HP:0000189)2.22938565
31Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.21389589
32Ankle clonus (HP:0011448)2.21058882
33Muscle fiber splitting (HP:0003555)2.20614424
34Renovascular hypertension (HP:0100817)2.20184350
35Ankyloglossia (HP:0010296)2.14183050
36Hypoplastic ischia (HP:0003175)2.13366994
37Pointed chin (HP:0000307)2.12586099
38Hand muscle atrophy (HP:0009130)2.12530576
39Aneurysm (HP:0002617)2.10804509
40Sleep apnea (HP:0010535)2.09677228
41Hyporeflexia of lower limbs (HP:0002600)2.09223016
42Upper limb amyotrophy (HP:0009129)2.06891029
43Distal upper limb amyotrophy (HP:0007149)2.06891029
44Overriding aorta (HP:0002623)2.03164453
45Type 1 muscle fiber predominance (HP:0003803)2.02979250
46Hyperkalemia (HP:0002153)2.02558994
47Postural instability (HP:0002172)2.01086343
48Increased connective tissue (HP:0009025)2.00169981
49Lymphangioma (HP:0100764)2.00042293
50Dysmetric saccades (HP:0000641)1.99945647
51Bowel diverticulosis (HP:0005222)1.99598049
52Volvulus (HP:0002580)1.99450004
53Supernumerary ribs (HP:0005815)1.98499156
54Increased nuchal translucency (HP:0010880)1.97434347
55Aortic aneurysm (HP:0004942)1.96304901
56Overgrowth (HP:0001548)1.95316570
57Aqueductal stenosis (HP:0002410)1.95260733
58Broad thumb (HP:0011304)1.95250108
59Abnormality of binocular vision (HP:0011514)1.94748253
60Diplopia (HP:0000651)1.94748253
61Stereotypic behavior (HP:0000733)1.93800419
62Astrocytoma (HP:0009592)1.92373414
63Abnormality of the astrocytes (HP:0100707)1.92373414
64Onion bulb formation (HP:0003383)1.90713762
65Laryngomalacia (HP:0001601)1.90326250
66Bladder diverticulum (HP:0000015)1.88906094
67Protrusio acetabuli (HP:0003179)1.88252795
68Heterotopia (HP:0002282)1.88198506
69Disproportionate tall stature (HP:0001519)1.87376141
70Abnormality of skeletal muscle fiber size (HP:0012084)1.87172475
71Exercise-induced myalgia (HP:0003738)1.85881557
72Hemiplegia (HP:0002301)1.85088230
73Thick eyebrow (HP:0000574)1.85052190
74Hypercortisolism (HP:0001578)1.84971436
75Tracheomalacia (HP:0002779)1.84733354
76Centrally nucleated skeletal muscle fibers (HP:0003687)1.84398501
77Flat cornea (HP:0007720)1.84117853
78Flat acetabular roof (HP:0003180)1.82931511
79Truncal obesity (HP:0001956)1.81987812
80Sudden death (HP:0001699)1.81853793
81Segmental peripheral demyelination/remyelination (HP:0003481)1.81616401
82Trigonocephaly (HP:0000243)1.81201505
83Papilledema (HP:0001085)1.80762421
84Ventricular fibrillation (HP:0001663)1.79429587
85Germ cell neoplasia (HP:0100728)1.79411527
86Persistence of primary teeth (HP:0006335)1.78062335
87Abnormality of the 4th metacarpal (HP:0010012)1.75796697
88Mildly elevated creatine phosphokinase (HP:0008180)1.75577546
89Lower limb amyotrophy (HP:0007210)1.75340265
90Neonatal short-limb short stature (HP:0008921)1.74783259
91Abnormality of the lower motor neuron (HP:0002366)1.74162993
92Mask-like facies (HP:0000298)1.72609736
93Ulnar bowing (HP:0003031)1.71856030
94Bell-shaped thorax (HP:0001591)1.71168652
95Supranuclear gaze palsy (HP:0000605)1.70859972
96Turricephaly (HP:0000262)1.70737672
97Visual hallucinations (HP:0002367)1.69809403
98Metaphyseal cupping (HP:0003021)1.69775760
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.69742216
100Rectal prolapse (HP:0002035)1.69622128
101Abnormality of the left ventricular outflow tract (HP:0011103)1.69388978
102Subaortic stenosis (HP:0001682)1.69388978
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68798859
104Mitral valve prolapse (HP:0001634)1.68182783
105EMG: neuropathic changes (HP:0003445)1.67681238
106Decreased motor nerve conduction velocity (HP:0003431)1.67526970
107Annular pancreas (HP:0001734)1.67293338
108Anal stenosis (HP:0002025)1.66103506
109Abnormality of oral frenula (HP:0000190)1.65940767
110Ventricular tachycardia (HP:0004756)1.65854781
111Thin bony cortex (HP:0002753)1.65261209
112Striae distensae (HP:0001065)1.65153680
113Broad palm (HP:0001169)1.64837865
114Dislocated radial head (HP:0003083)1.64231856
115Open mouth (HP:0000194)1.63084288
116Eczematoid dermatitis (HP:0000976)1.63021462
117Atelectasis (HP:0100750)1.60222891
118Proximal amyotrophy (HP:0007126)1.60213238
119Cellulitis (HP:0100658)1.60015031
120Bundle branch block (HP:0011710)1.59291952
121Supernumerary bones of the axial skeleton (HP:0009144)1.58860422
122Sporadic (HP:0003745)1.58662730
123Abnormality of the radial head (HP:0003995)1.58626350
124Impaired smooth pursuit (HP:0007772)1.58132796
125Wide anterior fontanel (HP:0000260)1.57694498
126Cerebral inclusion bodies (HP:0100314)1.57681725
127Aplasia of the phalanges of the hand (HP:0009802)1.57222498
128Aplasia involving bones of the extremities (HP:0009825)1.57222498
129Aplasia involving bones of the upper limbs (HP:0009823)1.57222498
130Arnold-Chiari malformation (HP:0002308)1.57094678
131Abnormality of incisor morphology (HP:0011063)1.56986997
132Long palpebral fissure (HP:0000637)1.56818968
133Action tremor (HP:0002345)1.56254015
134Deviation of the hallux (HP:0010051)1.56043215
135Arterial tortuosity (HP:0005116)1.55990957
136Ependymoma (HP:0002888)1.55783990
137Bowel incontinence (HP:0002607)1.55091935
138Subacute progressive viral hepatitis (HP:0006572)1.55064184
139Distal lower limb amyotrophy (HP:0008944)1.54977648
140Hypoventilation (HP:0002791)1.54976736
141Broad phalanges of the hand (HP:0009768)1.54616561
142Transitional cell carcinoma of the bladder (HP:0006740)1.54227887
143Thin ribs (HP:0000883)1.53933851
144Papilloma (HP:0012740)1.53891162
145Verrucae (HP:0200043)1.53891162
146Severe short stature (HP:0003510)1.53537648
147Short phalanx of the thumb (HP:0009660)1.53370510
148Resting tremor (HP:0002322)1.52914298
149Bronchomalacia (HP:0002780)1.52790562
150Vascular tortuosity (HP:0004948)1.52634647
151Abnormal social behavior (HP:0012433)1.52478489
152Impaired social interactions (HP:0000735)1.52478489
153Spina bifida occulta (HP:0003298)1.52387997
154Sacral dimple (HP:0000960)1.51603231
155Abnormality of the pubic bones (HP:0003172)1.51573057
156Peripheral hypomyelination (HP:0007182)1.50852068
157Deep palmar crease (HP:0006191)1.50436231
158Hallux valgus (HP:0001822)1.50210687
159Leiomyosarcoma (HP:0100243)1.49499232
160Uterine leiomyosarcoma (HP:0002891)1.49499232
161Smooth philtrum (HP:0000319)1.49377038
162Precocious puberty (HP:0000826)1.49146635
163Broad finger (HP:0001500)1.48660411
164Malignant gastrointestinal tract tumors (HP:0006749)1.48176283
165Gastrointestinal carcinoma (HP:0002672)1.48176283
166Depression (HP:0000716)1.47999088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.07666374
2MAP3K103.44845358
3TRIB33.23245560
4CAMK1G2.87795161
5ERN12.47482988
6BRD42.45654323
7CAMK1D2.44036445
8ICK2.31484306
9RIPK12.29217312
10EEF2K2.29146732
11SIK21.97548126
12PRPF4B1.97310898
13PDGFRA1.91942728
14DMPK1.88723803
15PKN21.80255547
16TNK21.78322788
17MARK11.77100677
18SIK11.75829987
19PRKD31.74686451
20RIPK41.64855579
21MAP3K91.57455799
22TYRO31.52960823
23PTK61.47861709
24WNK11.38765972
25CDC42BPA1.34264612
26MTOR1.32697217
27STK381.32533427
28HIPK21.29914836
29MARK21.24435491
30AKT31.23074297
31TTN1.22717318
32SMG11.21494116
33PRKCH1.20496266
34FGFR21.19620555
35UHMK11.17724442
36LATS11.16737448
37TAOK11.14231881
38ALK1.12948341
39NTRK31.12930510
40INSRR1.12447058
41PAK61.02638483
42PTK21.01699635
43PRKD21.00806139
44MAP3K41.00764989
45NTRK20.98014379
46MAP3K70.97903066
47SGK30.97667917
48BMX0.95206658
49MAPK150.95121428
50RET0.95060584
51CAMKK10.93652070
52CSNK1A1L0.93297463
53EPHA30.90784687
54MAPK120.89229581
55PDGFRB0.86055828
56PDPK10.85240777
57MAP3K60.85063863
58MAP3K130.85029188
59DYRK1B0.83798731
60MAP3K20.78264659
61LMTK20.77758144
62EPHB20.77579677
63MAPK70.76744439
64CAMK40.76159175
65PRKD10.75433607
66STK110.75368593
67NTRK10.75105560
68CASK0.74354730
69RPS6KL10.74142968
70RPS6KC10.74142968
71PDK10.73060685
72LATS20.71858539
73DDR20.70561316
74FGFR30.70453645
75MAP2K30.67164781
76MAP3K10.65029841
77PNCK0.63468237
78WNK40.63387185
79KSR10.61540000
80CDK90.61404149
81FES0.60803076
82PAK30.60717425
83WNK30.60696625
84RPS6KA60.60669227
85TGFBR20.60599494
86PRKAA10.60366295
87PRKCZ0.59731333
88GRK60.59519611
89FGFR10.59257751
90CSNK1G20.58543971
91DAPK20.58510056
92SIK30.58365539
93NEK20.58226532
94SCYL20.57598610
95CDK60.57359537
96PAK20.57331702
97NEK10.56498164
98MAP3K110.55941184
99FER0.55743557
100BLK0.55725972
101SGK20.54270934
102KSR20.53653658
103NLK0.53634123
104PRKAA20.53481816
105CDK50.53058220
106PHKG10.52313166
107PHKG20.52313166
108RPS6KA20.52242581
109SGK10.51361628
110ERBB20.50234215
111MAP2K40.49183890
112CAMK10.48821432
113MINK10.46604933
114RPS6KA10.45513331
115OBSCN0.45311628
116EPHB10.45290851
117CSNK1G10.44825290
118PAK40.44741011
119MAP4K10.44503385
120CSK0.43614678
121FGFR40.42852471
122SGK2230.42120188
123SGK4940.42120188
124DYRK1A0.42015258
125MAPK100.41139314
126PASK0.40874077
127CSNK1G30.40711393
128TAOK30.40700715
129FYN0.40588876
130LRRK20.40530679
131GSK3B0.40319119
132MAPK80.40312479
133IRAK40.39194593
134HCK0.38471353
135MAPK10.38109068

Predicted pathways (KEGG)

RankGene SetZ-score
1Type II diabetes mellitus_Homo sapiens_hsa049301.81048901
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73034104
3Lysine degradation_Homo sapiens_hsa003101.68253208
4Insulin secretion_Homo sapiens_hsa049111.60762507
5Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49861181
6mTOR signaling pathway_Homo sapiens_hsa041501.46447542
7Thyroid hormone signaling pathway_Homo sapiens_hsa049191.44155405
8Glioma_Homo sapiens_hsa052141.41068060
9Long-term potentiation_Homo sapiens_hsa047201.40009936
10Chronic myeloid leukemia_Homo sapiens_hsa052201.39702462
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39415892
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.37314464
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33234120
14Gastric acid secretion_Homo sapiens_hsa049711.33117377
15Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32033116
16Notch signaling pathway_Homo sapiens_hsa043301.31178435
17Estrogen signaling pathway_Homo sapiens_hsa049151.26184586
18Adherens junction_Homo sapiens_hsa045201.25827096
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.25006698
20B cell receptor signaling pathway_Homo sapiens_hsa046621.22777440
21Circadian entrainment_Homo sapiens_hsa047131.22185548
22Non-small cell lung cancer_Homo sapiens_hsa052231.21595109
23Dorso-ventral axis formation_Homo sapiens_hsa043201.21235450
24Endometrial cancer_Homo sapiens_hsa052131.18258893
25Fatty acid biosynthesis_Homo sapiens_hsa000611.16905889
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14961206
27Insulin resistance_Homo sapiens_hsa049311.14862053
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13391197
29Nicotine addiction_Homo sapiens_hsa050331.12543268
30GnRH signaling pathway_Homo sapiens_hsa049121.12440384
31Cocaine addiction_Homo sapiens_hsa050301.12432182
32Dopaminergic synapse_Homo sapiens_hsa047281.12418718
33Dilated cardiomyopathy_Homo sapiens_hsa054141.12362798
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11801511
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.11753748
36Renal cell carcinoma_Homo sapiens_hsa052111.11207757
37Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09666336
38Proteoglycans in cancer_Homo sapiens_hsa052051.09575322
39Salivary secretion_Homo sapiens_hsa049701.09519756
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.06953074
41Oxytocin signaling pathway_Homo sapiens_hsa049211.06474272
42Cholinergic synapse_Homo sapiens_hsa047251.04735516
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04626698
44ErbB signaling pathway_Homo sapiens_hsa040121.04509674
45Focal adhesion_Homo sapiens_hsa045101.04131819
46VEGF signaling pathway_Homo sapiens_hsa043701.04015368
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03119856
48Renin secretion_Homo sapiens_hsa049241.02761799
49Colorectal cancer_Homo sapiens_hsa052101.02211911
50Basal cell carcinoma_Homo sapiens_hsa052171.01217958
51Glutamatergic synapse_Homo sapiens_hsa047241.00749860
52Pancreatic cancer_Homo sapiens_hsa052120.99874029
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98438839
54Amphetamine addiction_Homo sapiens_hsa050310.98395858
55Melanogenesis_Homo sapiens_hsa049160.98347037
56Olfactory transduction_Homo sapiens_hsa047400.98150658
57Prolactin signaling pathway_Homo sapiens_hsa049170.97868020
58Insulin signaling pathway_Homo sapiens_hsa049100.97660132
59Axon guidance_Homo sapiens_hsa043600.96945130
60Glucagon signaling pathway_Homo sapiens_hsa049220.96665049
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.96267303
62Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96189186
63GABAergic synapse_Homo sapiens_hsa047270.95403528
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94910153
65Morphine addiction_Homo sapiens_hsa050320.94058281
66Hedgehog signaling pathway_Homo sapiens_hsa043400.93746203
67Gap junction_Homo sapiens_hsa045400.93693097
68Wnt signaling pathway_Homo sapiens_hsa043100.92566150
69cAMP signaling pathway_Homo sapiens_hsa040240.91217396
70Synaptic vesicle cycle_Homo sapiens_hsa047210.91055384
71Osteoclast differentiation_Homo sapiens_hsa043800.90322772
72Choline metabolism in cancer_Homo sapiens_hsa052310.89726841
73MicroRNAs in cancer_Homo sapiens_hsa052060.89147776
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88670827
75Inositol phosphate metabolism_Homo sapiens_hsa005620.87957767
76Hippo signaling pathway_Homo sapiens_hsa043900.87390365
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87267414
78AMPK signaling pathway_Homo sapiens_hsa041520.86250990
79Long-term depression_Homo sapiens_hsa047300.86093175
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.85866333
81Thyroid hormone synthesis_Homo sapiens_hsa049180.85434117
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85364531
83Calcium signaling pathway_Homo sapiens_hsa040200.84603300
84Pancreatic secretion_Homo sapiens_hsa049720.84595428
85MAPK signaling pathway_Homo sapiens_hsa040100.83965372
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83611249
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82360302
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79509274
89Rap1 signaling pathway_Homo sapiens_hsa040150.79191869
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.77603547
91Endocytosis_Homo sapiens_hsa041440.76076723
92Prostate cancer_Homo sapiens_hsa052150.76035943
93Chemokine signaling pathway_Homo sapiens_hsa040620.75422863
94Platelet activation_Homo sapiens_hsa046110.75206259
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75070380
96Small cell lung cancer_Homo sapiens_hsa052220.72747708
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71910280
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71661881
99Acute myeloid leukemia_Homo sapiens_hsa052210.71618040
100FoxO signaling pathway_Homo sapiens_hsa040680.70954928
101Amoebiasis_Homo sapiens_hsa051460.70567592
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69817781
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69393583
104Bladder cancer_Homo sapiens_hsa052190.69067287
105Tight junction_Homo sapiens_hsa045300.67847948
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.67444458
107T cell receptor signaling pathway_Homo sapiens_hsa046600.66970088
108Vascular smooth muscle contraction_Homo sapiens_hsa042700.66875440
109Taste transduction_Homo sapiens_hsa047420.66837985
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66661347
111Circadian rhythm_Homo sapiens_hsa047100.66273122
112Ras signaling pathway_Homo sapiens_hsa040140.65903233
113Bile secretion_Homo sapiens_hsa049760.63509740
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61631524
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.58630256
116Serotonergic synapse_Homo sapiens_hsa047260.57603435

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