RERG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1C21-steroid hormone biosynthetic process (GO:0006700)4.97835494
2vocalization behavior (GO:0071625)4.58268936
3mating behavior (GO:0007617)4.52136251
4regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.45852436
5regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.45852436
6striatum development (GO:0021756)4.23367125
7prostate gland growth (GO:0060736)4.21533598
8regulation of glutamate secretion (GO:0014048)4.18731204
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15731674
10glucocorticoid biosynthetic process (GO:0006704)4.14658212
11synaptic vesicle exocytosis (GO:0016079)4.09632075
12regulation of neurotransmitter uptake (GO:0051580)4.00718198
13prepulse inhibition (GO:0060134)3.98193331
14negative regulation of amino acid transport (GO:0051956)3.90340490
15glucocorticoid metabolic process (GO:0008211)3.88397493
16synaptic transmission, dopaminergic (GO:0001963)3.87664053
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.84957351
18behavioral response to nicotine (GO:0035095)3.83326583
19regulation of synapse structural plasticity (GO:0051823)3.82315348
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.76976641
21locomotory exploration behavior (GO:0035641)3.76938951
22regulation of glutamate receptor signaling pathway (GO:1900449)3.67770100
23regulation of short-term neuronal synaptic plasticity (GO:0048172)3.66019443
24limb bud formation (GO:0060174)3.62072861
25neurotransmitter secretion (GO:0007269)3.60438596
26synaptic vesicle maturation (GO:0016188)3.60017302
27norepinephrine metabolic process (GO:0042415)3.57491387
28regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.57376510
29regulation of synaptic vesicle exocytosis (GO:2000300)3.55476546
30estrogen biosynthetic process (GO:0006703)3.53955843
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.48650978
32piRNA metabolic process (GO:0034587)3.47236256
33glutamate secretion (GO:0014047)3.46819582
34neurotransmitter-gated ion channel clustering (GO:0072578)3.42567342
35regulation of neuronal synaptic plasticity (GO:0048168)3.40157792
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.39939959
37exploration behavior (GO:0035640)3.37868092
38regulation of long-term neuronal synaptic plasticity (GO:0048169)3.36869802
39synaptic vesicle docking involved in exocytosis (GO:0016081)3.35886756
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34971923
41dopamine transport (GO:0015872)3.33896447
42DNA methylation involved in gamete generation (GO:0043046)3.32934377
43neuron cell-cell adhesion (GO:0007158)3.32221856
44neuron-neuron synaptic transmission (GO:0007270)3.31174218
45regulation of female receptivity (GO:0045924)3.30879017
46long-term synaptic potentiation (GO:0060291)3.27000763
47response to insecticide (GO:0017085)3.24792216
48regulation of synaptic vesicle transport (GO:1902803)3.23063187
49female mating behavior (GO:0060180)3.16186103
50regulation of synaptic transmission, dopaminergic (GO:0032225)3.14639792
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.14497589
52cellular response to cadmium ion (GO:0071276)3.12569143
53androgen biosynthetic process (GO:0006702)3.11910529
54prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.07431467
55startle response (GO:0001964)3.03980204
56head development (GO:0060322)3.03879577
57adaptation of signaling pathway (GO:0023058)3.03633899
58C21-steroid hormone metabolic process (GO:0008207)3.03482417
59regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02223630
60behavioral response to cocaine (GO:0048148)3.00683781
61negative regulation of cytosolic calcium ion concentration (GO:0051481)3.00309384
62synaptic transmission, glutamatergic (GO:0035249)2.99805102
63regulation of protein kinase A signaling (GO:0010738)2.99723915
64response to amphetamine (GO:0001975)2.99372539
65glutamate receptor signaling pathway (GO:0007215)2.98763013
66protein localization to synapse (GO:0035418)2.98464642
67neuron recognition (GO:0008038)2.98249776
68negative regulation of neurotransmitter transport (GO:0051589)2.97824123
69tachykinin receptor signaling pathway (GO:0007217)2.97355478
70positive regulation of neurotransmitter transport (GO:0051590)2.94527956
71activation of protein kinase A activity (GO:0034199)2.93397928
72positive regulation of amino acid transport (GO:0051957)2.89310618
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.89047663
74toxin metabolic process (GO:0009404)2.87678679
75catecholamine transport (GO:0051937)2.87564227
76regulation of neurotransmitter levels (GO:0001505)2.86554308
77positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.86377582
78cornea development in camera-type eye (GO:0061303)2.85908297
79regulation of amino acid transport (GO:0051955)2.85883685
80regulation of synaptic plasticity (GO:0048167)2.85742564
81proline transport (GO:0015824)2.85606215
82transmission of nerve impulse (GO:0019226)2.85501785
83neurotransmitter transport (GO:0006836)2.84372446
84keratan sulfate catabolic process (GO:0042340)2.84295462
85dendritic spine morphogenesis (GO:0060997)2.83835973
86mesonephros development (GO:0001823)2.83417718
87multi-organism reproductive behavior (GO:0044705)2.82388007
88positive regulation of gastrulation (GO:2000543)2.81690196
89regulation of hexokinase activity (GO:1903299)2.81219465
90regulation of glucokinase activity (GO:0033131)2.81219465
91artery smooth muscle contraction (GO:0014824)2.80184223
92endocrine hormone secretion (GO:0060986)2.80006716
93sympathetic nervous system development (GO:0048485)2.79682279
94negative regulation of organic acid transport (GO:0032891)2.79658929
95regulation of dopamine secretion (GO:0014059)2.79287999
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.77960052
97gamma-aminobutyric acid transport (GO:0015812)2.76994823
98tonic smooth muscle contraction (GO:0014820)2.75657985
99cardiac right ventricle morphogenesis (GO:0003215)2.74946163
100regulation of neurotransmitter transport (GO:0051588)2.74469880
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.74123319
102somite development (GO:0061053)2.72710629
103regulation of excitatory postsynaptic membrane potential (GO:0060079)2.72338088
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72281346
105positive regulation of catecholamine secretion (GO:0033605)2.71107346
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68764227
107axonal fasciculation (GO:0007413)2.68637743
108behavioral fear response (GO:0001662)2.68297967
109behavioral defense response (GO:0002209)2.68297967
110uterus development (GO:0060065)2.68229830
111neurotransmitter biosynthetic process (GO:0042136)2.68008533
112long-term memory (GO:0007616)2.67924834
113behavioral response to ethanol (GO:0048149)2.67750403
114reproductive behavior (GO:0019098)2.67698813
115positive regulation of amine transport (GO:0051954)2.67428244
116adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.67395686
117inner ear receptor stereocilium organization (GO:0060122)2.66327367
118negative regulation of amine transport (GO:0051953)2.65588822
119regulation of synaptic transmission, glutamatergic (GO:0051966)2.65010111
120regulation of catecholamine metabolic process (GO:0042069)2.64509952
121regulation of dopamine metabolic process (GO:0042053)2.64509952
122positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.63557200
123layer formation in cerebral cortex (GO:0021819)2.62619802
124vascular smooth muscle contraction (GO:0014829)2.62489196
125L-fucose catabolic process (GO:0042355)2.62196198
126fucose catabolic process (GO:0019317)2.62196198
127L-fucose metabolic process (GO:0042354)2.62196198
128dopamine receptor signaling pathway (GO:0007212)2.62122254
129serotonin metabolic process (GO:0042428)2.62054770
130regulation of dendritic spine morphogenesis (GO:0061001)2.61760223
131auditory behavior (GO:0031223)2.61038057
132positive regulation of synaptic transmission (GO:0050806)2.60963888
133fear response (GO:0042596)2.58900260
134protein localization to cilium (GO:0061512)2.58307447
135auditory receptor cell stereocilium organization (GO:0060088)2.54978941
136primary amino compound metabolic process (GO:1901160)2.52454651
137negative regulation of telomere maintenance (GO:0032205)2.51354621
138water-soluble vitamin biosynthetic process (GO:0042364)2.50102341
139cGMP biosynthetic process (GO:0006182)2.48296444
140glomerular basement membrane development (GO:0032836)2.47963383
141smooth muscle contraction (GO:0006939)2.47330475
142peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44832916
143phasic smooth muscle contraction (GO:0014821)2.43449236
144lung vasculature development (GO:0060426)2.42594222
145benzene-containing compound metabolic process (GO:0042537)2.42508200
146platelet dense granule organization (GO:0060155)2.42159117
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41209993
148mannosylation (GO:0097502)2.40991139
149cilium morphogenesis (GO:0060271)2.39972852
150axoneme assembly (GO:0035082)2.39030156
151response to nitrosative stress (GO:0051409)2.38964266
152preassembly of GPI anchor in ER membrane (GO:0016254)2.38920281
153L-methionine salvage (GO:0071267)2.38545819
154L-methionine biosynthetic process (GO:0071265)2.38545819
155amino acid salvage (GO:0043102)2.38545819
156embryonic epithelial tube formation (GO:0001838)2.38097742
157xenobiotic catabolic process (GO:0042178)2.37367555
158cGMP metabolic process (GO:0046068)2.35853737
159exocrine pancreas development (GO:0031017)2.35521501
160regulation of meiosis I (GO:0060631)2.34998389
161positive regulation of meiotic cell cycle (GO:0051446)2.34235418
162positive regulation of meiosis (GO:0045836)2.34066895
163centriole replication (GO:0007099)2.32740758
164peptidyl-histidine modification (GO:0018202)2.31641110
165otic vesicle formation (GO:0030916)2.31428938
166activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.28354022
167glomerular filtration (GO:0003094)2.27958588
168positive regulation of glomerulus development (GO:0090193)2.27856811
169lung secretory cell differentiation (GO:0061140)2.26524293
170detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26438327
171cochlea development (GO:0090102)2.26168067
172synaptic transmission, cholinergic (GO:0007271)2.23080944
173cellular response to toxic substance (GO:0097237)2.21967121
174kidney morphogenesis (GO:0060993)2.21578073
175mechanosensory behavior (GO:0007638)2.21236668
176neuronal action potential (GO:0019228)2.20402057
177reflex (GO:0060004)2.19252626
178metanephros development (GO:0001656)2.18376436
179negative regulation of kidney development (GO:0090185)2.18304855
180cellular ketone body metabolic process (GO:0046950)2.17959003
181urinary tract smooth muscle contraction (GO:0014848)2.17066682
182C-terminal protein lipidation (GO:0006501)2.16298388
183short-term memory (GO:0007614)2.15784032
184detection of light stimulus involved in visual perception (GO:0050908)2.15614179
185detection of light stimulus involved in sensory perception (GO:0050962)2.15614179
186positive regulation of mitochondrial fission (GO:0090141)2.15490167
187epithelial tube formation (GO:0072175)2.14617934
188mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.14050992
189epithelial cilium movement (GO:0003351)2.13268483
190positive regulation of uterine smooth muscle contraction (GO:0070474)2.13173595
191positive regulation of fatty acid oxidation (GO:0046321)2.12528304
192ubiquinone biosynthetic process (GO:0006744)2.12486923
193positive regulation of digestive system process (GO:0060456)2.11897067
194protein-cofactor linkage (GO:0018065)2.11288515

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89034089
2GBX2_23144817_ChIP-Seq_PC3_Human3.57739855
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07595309
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06399329
5EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75327901
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75327901
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.72351700
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68480222
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.66778887
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63275042
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.56531126
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47198435
13VDR_22108803_ChIP-Seq_LS180_Human2.43785581
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.41701926
15IGF1R_20145208_ChIP-Seq_DFB_Human2.41389012
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38105332
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.38041646
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29784058
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.21323530
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07533817
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.05680193
22FUS_26573619_Chip-Seq_HEK293_Human2.03707887
23DROSHA_22980978_ChIP-Seq_HELA_Human2.00628366
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.00211006
25ER_23166858_ChIP-Seq_MCF-7_Human1.98121334
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95010978
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.93174507
28* ESR1_21235772_ChIP-Seq_MCF-7_Human1.91841631
29REST_21632747_ChIP-Seq_MESCs_Mouse1.90170304
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86417715
31EWS_26573619_Chip-Seq_HEK293_Human1.82960946
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.82083448
33AR_21572438_ChIP-Seq_LNCaP_Human1.73877282
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67522653
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.63996920
36SMAD4_21799915_ChIP-Seq_A2780_Human1.63738924
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.60602460
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59288203
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.57351772
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57256835
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56152787
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.56023506
43* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54927974
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54528710
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52331796
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.50714955
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50073157
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.50017411
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49930593
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.49559739
51TAF15_26573619_Chip-Seq_HEK293_Human1.46835703
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46071662
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44071136
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43843113
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42912747
56CBP_20019798_ChIP-Seq_JUKART_Human1.42912747
57P300_19829295_ChIP-Seq_ESCs_Human1.41197208
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39749265
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37502020
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36222682
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32154274
62TP53_22573176_ChIP-Seq_HFKS_Human1.31603309
63* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30111112
64* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29035339
65* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.28963208
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.28824743
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28808518
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.28794712
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.28548442
70* AR_25329375_ChIP-Seq_VCAP_Human1.25911618
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25404057
72* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25373451
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.24600294
74TP53_18474530_ChIP-ChIP_U2OS_Human1.24228023
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21054717
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21007410
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.19213924
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19096836
79TCF4_22108803_ChIP-Seq_LS180_Human1.19059656
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18551241
81ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18482344
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18429581
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18199418
84HOXB7_26014856_ChIP-Seq_BT474_Human1.17522390
85KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16612593
86* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.14060410
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13794604
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12766516
89LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12683296
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11709421
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.11220629
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10421093
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09926212
94* AHR_22903824_ChIP-Seq_MCF-7_Human1.09297589
95* ARNT_22903824_ChIP-Seq_MCF-7_Human1.09156090
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09003693
97SOX2_19829295_ChIP-Seq_ESCs_Human1.08032538
98NANOG_19829295_ChIP-Seq_ESCs_Human1.08032538
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07940105
100SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07185733
101AR_19668381_ChIP-Seq_PC3_Human1.06865635
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06489665
103STAT3_23295773_ChIP-Seq_U87_Human1.06305761
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06226109
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05818917
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05203649
107* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05202718
108* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05202718
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.04971753
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04940609
111NFE2_27457419_Chip-Seq_LIVER_Mouse1.04935043
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04902543
113RING1B_27294783_Chip-Seq_NPCs_Mouse1.04250065
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04181607
115NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04181607
116P53_22387025_ChIP-Seq_ESCs_Mouse1.02313211
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01258225
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01100131
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01042296
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.01042296
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.00962057
122BCAT_22108803_ChIP-Seq_LS180_Human1.00465762
123SMAD4_21741376_ChIP-Seq_HESCs_Human1.00202989
124RNF2_27304074_Chip-Seq_NSC_Mouse1.00136021
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99831620
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99070189
127GATA3_21878914_ChIP-Seq_MCF-7_Human0.98785301
128BP1_19119308_ChIP-ChIP_Hs578T_Human0.98080356
129* RUNX2_22187159_ChIP-Seq_PCA_Human0.96411488
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.95112797
131* ESR1_20079471_ChIP-ChIP_T-47D_Human0.94936049
132* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94748551
133* SMAD4_21741376_ChIP-Seq_EPCs_Human0.94037409
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.92681951
135* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92585868
136ZNF274_21170338_ChIP-Seq_K562_Hela0.92342033
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91459274
138CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91328166
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91090286
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89602550
141TCF4_23295773_ChIP-Seq_U87_Human0.89377488
142JUN_21703547_ChIP-Seq_K562_Human0.89146137
143SMAD_19615063_ChIP-ChIP_OVARY_Human0.88549352

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.06085053
2MP0004859_abnormal_synaptic_plasticity4.61777802
3MP0003880_abnormal_central_pattern4.32228197
4MP0003635_abnormal_synaptic_transmissio3.35420345
5MP0001529_abnormal_vocalization3.21438234
6MP0009745_abnormal_behavioral_response2.88457182
7MP0002909_abnormal_adrenal_gland2.80408020
8MP0002063_abnormal_learning/memory/cond2.77033309
9MP0003122_maternal_imprinting2.48414392
10MP0002102_abnormal_ear_morphology2.42708205
11MP0002064_seizures2.41945980
12MP0009046_muscle_twitch2.32292279
13MP0008995_early_reproductive_senescence2.28227998
14MP0002572_abnormal_emotion/affect_behav2.27100922
15MP0001501_abnormal_sleep_pattern2.23314089
16MP0004270_analgesia2.20356913
17MP0009780_abnormal_chondrocyte_physiolo2.16596320
18MP0000427_abnormal_hair_cycle2.15651024
19MP0005503_abnormal_tendon_morphology2.08373212
20MP0000639_abnormal_adrenal_gland1.97521205
21MP0001968_abnormal_touch/_nociception1.96738458
22MP0002272_abnormal_nervous_system1.95875641
23MP0005646_abnormal_pituitary_gland1.85197895
24MP0000566_synostosis1.85139955
25MP0002254_reproductive_system_inflammat1.84350994
26MP0001440_abnormal_grooming_behavior1.82802053
27MP0002734_abnormal_mechanical_nocicepti1.80493352
28MP0000383_abnormal_hair_follicle1.80028405
29MP0003195_calcinosis1.75569564
30MP0008877_abnormal_DNA_methylation1.71908672
31MP0001905_abnormal_dopamine_level1.70557380
32MP0001486_abnormal_startle_reflex1.66667200
33MP0005551_abnormal_eye_electrophysiolog1.64369889
34MP0006276_abnormal_autonomic_nervous1.64048383
35MP0002736_abnormal_nociception_after1.59416444
36MP0005386_behavior/neurological_phenoty1.55209114
37MP0004924_abnormal_behavior1.55209114
38MP0002160_abnormal_reproductive_system1.52891659
39MP0003878_abnormal_ear_physiology1.48977636
40MP0005377_hearing/vestibular/ear_phenot1.48977636
41MP0005670_abnormal_white_adipose1.46945598
42MP0008961_abnormal_basal_metabolism1.46861058
43MP0005423_abnormal_somatic_nervous1.44267344
44MP0002837_dystrophic_cardiac_calcinosis1.42413508
45MP0002751_abnormal_autonomic_nervous1.41790517
46MP0001970_abnormal_pain_threshold1.41370013
47MP0004043_abnormal_pH_regulation1.40946015
48MP0002557_abnormal_social/conspecific_i1.39417194
49MP0000569_abnormal_digit_pigmentation1.35838958
50MP0004858_abnormal_nervous_system1.33539235
51MP0001177_atelectasis1.33483912
52MP0000751_myopathy1.32451279
53MP0002184_abnormal_innervation1.30738679
54MP0003787_abnormal_imprinting1.30070904
55MP0002735_abnormal_chemical_nociception1.29862327
56MP0002638_abnormal_pupillary_reflex1.29229511
57MP0005623_abnormal_meninges_morphology1.28523661
58MP0008438_abnormal_cutaneous_collagen1.27660869
59MP0002733_abnormal_thermal_nociception1.25006194
60MP0008872_abnormal_physiological_respon1.24628783
61MP0000013_abnormal_adipose_tissue1.22794366
62MP0005253_abnormal_eye_physiology1.22433674
63MP0002067_abnormal_sensory_capabilities1.22058337
64MP0004147_increased_porphyrin_level1.20593878
65MP0002938_white_spotting1.20380947
66MP0001919_abnormal_reproductive_system1.15531786
67MP0000538_abnormal_urinary_bladder1.15496014
68MP0004272_abnormal_basement_membrane1.14712533
69MP0003879_abnormal_hair_cell1.14307129
70MP0003136_yellow_coat_color1.13877598
71MP0000534_abnormal_ureter_morphology1.12996034
72MP0005389_reproductive_system_phenotype1.12763529
73MP0005075_abnormal_melanosome_morpholog1.12514084
74MP0003123_paternal_imprinting1.12197749
75MP0005275_abnormal_skin_tensile1.09786797
76MP0000955_abnormal_spinal_cord1.09149245
77MP0000778_abnormal_nervous_system1.08461273
78MP0003385_abnormal_body_wall1.07312737
79MP0000462_abnormal_digestive_system1.06794160
80MP0004085_abnormal_heartbeat1.06706994
81MP0010678_abnormal_skin_adnexa1.04794418
82MP0003283_abnormal_digestive_organ1.04163272
83MP0002234_abnormal_pharynx_morphology1.03904742
84MP0002928_abnormal_bile_duct1.02490543
85MP0003329_amyloid_beta_deposits1.02297157
86MP0002066_abnormal_motor_capabilities/c1.01937468
87MP0010368_abnormal_lymphatic_system1.01907051
88MP0003938_abnormal_ear_development1.01891787
89MP0004215_abnormal_myocardial_fiber1.01562588
90MP0004811_abnormal_neuron_physiology0.99735566
91MP0002069_abnormal_eating/drinking_beha0.97777188
92MP0003937_abnormal_limbs/digits/tail_de0.97410801
93MP0006072_abnormal_retinal_apoptosis0.96934355
94MP0000372_irregular_coat_pigmentation0.96910830
95MP0004883_abnormal_blood_vessel0.96226744
96MP0001765_abnormal_ion_homeostasis0.95166868
97MP0002295_abnormal_pulmonary_circulatio0.95125976
98MP0005220_abnormal_exocrine_pancreas0.95081957
99MP0003942_abnormal_urinary_system0.94898801
100MP0001756_abnormal_urination0.93978389
101MP0008569_lethality_at_weaning0.93884299
102MP0001984_abnormal_olfaction0.92666779
103MP0000049_abnormal_middle_ear0.92238026
104MP0008875_abnormal_xenobiotic_pharmacok0.91870628
105MP0004381_abnormal_hair_follicle0.91425258
106MP0001485_abnormal_pinna_reflex0.90674758
107MP0000647_abnormal_sebaceous_gland0.90255786
108MP0005083_abnormal_biliary_tract0.88791503
109MP0010030_abnormal_orbit_morphology0.88540329
110MP0009250_abnormal_appendicular_skeleto0.88478156
111MP0001661_extended_life_span0.88178110
112MP0001944_abnormal_pancreas_morphology0.87798961
113MP0003011_delayed_dark_adaptation0.86859171
114MP0000631_abnormal_neuroendocrine_gland0.85262673
115MP0010386_abnormal_urinary_bladder0.84403377
116MP0003638_abnormal_response/metabolism_0.84324880
117MP0002882_abnormal_neuron_morphology0.84112966
118MP0004036_abnormal_muscle_relaxation0.84004549
119MP0001958_emphysema0.83924934
120MP0000230_abnormal_systemic_arterial0.83841604
121MP0004142_abnormal_muscle_tone0.83765019
122MP0002282_abnormal_trachea_morphology0.83617473
123MP0003936_abnormal_reproductive_system0.83310835
124MP0004133_heterotaxia0.83295255
125MP0003137_abnormal_impulse_conducting0.83094905
126MP0005379_endocrine/exocrine_gland_phen0.82366586
127MP0002249_abnormal_larynx_morphology0.81668459
128MP0005535_abnormal_body_temperature0.80981752
129MP0003121_genomic_imprinting0.80790531
130MP0002009_preneoplasia0.80326201
131MP0002876_abnormal_thyroid_physiology0.79141458
132MP0003633_abnormal_nervous_system0.78805041
133MP0006138_congestive_heart_failure0.78599459
134MP0002108_abnormal_muscle_morphology0.78334271
135MP0000026_abnormal_inner_ear0.77647504
136MP0005248_abnormal_Harderian_gland0.77473650
137MP0003646_muscle_fatigue0.77325084
138MP0008874_decreased_physiological_sensi0.77143984
139MP0002653_abnormal_ependyma_morphology0.76350087
140MP0002098_abnormal_vibrissa_morphology0.76268933
141MP0005187_abnormal_penis_morphology0.73637133
142MP0001542_abnormal_bone_strength0.72810958
143MP0002152_abnormal_brain_morphology0.70930417
144MP0005167_abnormal_blood-brain_barrier0.70921926
145MP0004084_abnormal_cardiac_muscle0.70109200
146MP0001664_abnormal_digestion0.69773729
147MP0001299_abnormal_eye_distance/0.69684071
148MP0004484_altered_response_of0.68393179
149MP0001502_abnormal_circadian_rhythm0.66739225
150MP0005595_abnormal_vascular_smooth0.66579134
151MP0004885_abnormal_endolymph0.66231426
152MP0005645_abnormal_hypothalamus_physiol0.64740712

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.58238082
2Focal motor seizures (HP:0011153)5.04092905
3Pancreatic cysts (HP:0001737)4.31310108
4Concave nail (HP:0001598)4.17307191
5Focal seizures (HP:0007359)3.76644009
6Type II lissencephaly (HP:0007260)3.60553324
7Renal salt wasting (HP:0000127)3.60313798
8Pancreatic fibrosis (HP:0100732)3.49280670
9Protrusio acetabuli (HP:0003179)3.43868531
10True hermaphroditism (HP:0010459)3.43129335
11Annular pancreas (HP:0001734)3.39634656
12Abnormality of the renal cortex (HP:0011035)3.35662488
13Torticollis (HP:0000473)3.19061176
14Nephronophthisis (HP:0000090)3.14106946
15Limb dystonia (HP:0002451)3.09714898
16Abnormality of midbrain morphology (HP:0002418)3.09238857
17Molar tooth sign on MRI (HP:0002419)3.09238857
18Abnormality of the renal medulla (HP:0100957)3.00580090
19Cystic liver disease (HP:0006706)3.00102888
20Atonic seizures (HP:0010819)2.98647282
21Pheochromocytoma (HP:0002666)2.97154040
22Visual hallucinations (HP:0002367)2.96777829
23Impaired vibration sensation in the lower limbs (HP:0002166)2.92953363
24Epileptic encephalopathy (HP:0200134)2.91802830
25Anxiety (HP:0000739)2.91255479
26Generalized tonic-clonic seizures (HP:0002069)2.84377508
27Focal dystonia (HP:0004373)2.84128430
28Increased corneal curvature (HP:0100692)2.81159498
29Keratoconus (HP:0000563)2.81159498
30Enlarged penis (HP:0000040)2.81027304
31Medial flaring of the eyebrow (HP:0010747)2.78998974
32Progressive cerebellar ataxia (HP:0002073)2.77859961
33Craniofacial dystonia (HP:0012179)2.75694796
34Absence seizures (HP:0002121)2.75660304
35Hypoventilation (HP:0002791)2.63229549
36Decreased circulating renin level (HP:0003351)2.62042534
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.61569252
38Abnormal eating behavior (HP:0100738)2.59608153
39Neuroendocrine neoplasm (HP:0100634)2.53168202
40Acute necrotizing encephalopathy (HP:0006965)2.52534086
41Increased circulating renin level (HP:0000848)2.50552303
42Hypothermia (HP:0002045)2.50093529
43Dysdiadochokinesis (HP:0002075)2.48866709
44Congenital stationary night blindness (HP:0007642)2.48740896
45Hyperventilation (HP:0002883)2.48342966
46Hyperaldosteronism (HP:0000859)2.48240321
47Cerebellar dysplasia (HP:0007033)2.47440853
48Congenital, generalized hypertrichosis (HP:0004540)2.47132928
49Febrile seizures (HP:0002373)2.46493995
50Neonatal onset (HP:0003623)2.44332965
51Narrow nasal bridge (HP:0000446)2.43699421
52Action tremor (HP:0002345)2.43559548
53Renal cortical cysts (HP:0000803)2.41738102
54Tubular atrophy (HP:0000092)2.40748206
55Broad metatarsal (HP:0001783)2.39649480
56Fibular aplasia (HP:0002990)2.32628739
57Amblyopia (HP:0000646)2.32401038
58Orthostatic hypotension (HP:0001278)2.32003424
59Short tibia (HP:0005736)2.30650515
60Large for gestational age (HP:0001520)2.30042589
61Depression (HP:0000716)2.29927459
62Abnormality of renin-angiotensin system (HP:0000847)2.29302730
63Progressive macrocephaly (HP:0004481)2.28482181
64Polydipsia (HP:0001959)2.27626871
65Abnormal drinking behavior (HP:0030082)2.27626871
66Tubulointerstitial fibrosis (HP:0005576)2.27149619
67Abnormality of alanine metabolism (HP:0010916)2.26265399
68Hyperalaninemia (HP:0003348)2.26265399
69Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26265399
70Gait imbalance (HP:0002141)2.23698604
71Abnormality of dentin (HP:0010299)2.22765716
72Amelogenesis imperfecta (HP:0000705)2.20054990
73Genital tract atresia (HP:0001827)2.19823359
74Sensorimotor neuropathy (HP:0007141)2.18434567
75Abnormal mitochondria in muscle tissue (HP:0008316)2.17222564
76Increased CSF lactate (HP:0002490)2.15556412
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.14913475
78Dysmetria (HP:0001310)2.14831325
79Dialeptic seizures (HP:0011146)2.13244062
80Abnormal biliary tract physiology (HP:0012439)2.12881166
81Bile duct proliferation (HP:0001408)2.12881166
82Ulnar claw (HP:0001178)2.10832068
83Mitochondrial inheritance (HP:0001427)2.10339316
84Congenital primary aphakia (HP:0007707)2.10073551
85Acute encephalopathy (HP:0006846)2.10032259
86Vaginal atresia (HP:0000148)2.09901361
87Adrenal overactivity (HP:0002717)2.09759464
88Abnormality of the proximal phalanges of the hand (HP:0009834)2.09008116
89Abnormality of the lower motor neuron (HP:0002366)2.08796471
90Tubulointerstitial abnormality (HP:0001969)2.07403533
91Nephrogenic diabetes insipidus (HP:0009806)2.06159869
92Follicular hyperkeratosis (HP:0007502)2.04975229
93Broad-based gait (HP:0002136)2.04447316
94Short hallux (HP:0010109)2.03067191
95Coronal craniosynostosis (HP:0004440)2.02626585
96Atrophic scars (HP:0001075)2.01467749
97Arterial tortuosity (HP:0005116)2.01250201
98Cerebral inclusion bodies (HP:0100314)2.01137942
99Polyuria (HP:0000103)2.00400750
100Polyphagia (HP:0002591)1.99938728
101Hypokalemic alkalosis (HP:0001949)1.98335726
102Supranuclear gaze palsy (HP:0000605)1.96820611
103Male pseudohermaphroditism (HP:0000037)1.96764005
104Testicular neoplasm (HP:0010788)1.95243717
105Spinal canal stenosis (HP:0003416)1.94028228
106Poor suck (HP:0002033)1.93762050
107Neoplasm of the peripheral nervous system (HP:0100007)1.93531085
108Congenital hepatic fibrosis (HP:0002612)1.92778025
109Biconcave vertebral bodies (HP:0004586)1.92120873
110Fetal akinesia sequence (HP:0001989)1.91803547
111Tachypnea (HP:0002789)1.91562409
112Aplasia/Hypoplasia involving the musculature (HP:0001460)1.90617760
113Vascular tortuosity (HP:0004948)1.90255304
114Postaxial foot polydactyly (HP:0001830)1.89995356
115Tubulointerstitial nephritis (HP:0001970)1.89990018
116Aplasia/Hypoplasia of the hallux (HP:0008362)1.89279400
117Striae distensae (HP:0001065)1.88399815
118Aplasia/hypoplasia of the uterus (HP:0008684)1.87270220
119Aplasia/Hypoplasia of the fovea (HP:0008060)1.87096208
120Hypoplasia of the fovea (HP:0007750)1.87096208
121Premature rupture of membranes (HP:0001788)1.86639529
122Renal dysplasia (HP:0000110)1.82344122
123Ketoacidosis (HP:0001993)1.82215000
124Turricephaly (HP:0000262)1.81861254
125Oligomenorrhea (HP:0000876)1.81798785
126Severe muscular hypotonia (HP:0006829)1.81449373
127Breast carcinoma (HP:0003002)1.81428941
128Genetic anticipation (HP:0003743)1.80700260
129Aplasia involving bones of the upper limbs (HP:0009823)1.80622062
130Aplasia of the phalanges of the hand (HP:0009802)1.80622062
131Aplasia involving bones of the extremities (HP:0009825)1.80622062
132Hepatic necrosis (HP:0002605)1.80507837
133Abolished electroretinogram (ERG) (HP:0000550)1.80465423
134Lissencephaly (HP:0001339)1.79416580
135Ankle clonus (HP:0011448)1.77842101
136Bladder diverticulum (HP:0000015)1.77793472
137Furrowed tongue (HP:0000221)1.77303423
138Failure to thrive in infancy (HP:0001531)1.76460546
139Neurofibrillary tangles (HP:0002185)1.76145296
140Inability to walk (HP:0002540)1.75540452
141Hypokalemia (HP:0002900)1.75199852
142Facial shape deformation (HP:0011334)1.75122260
143Potter facies (HP:0002009)1.75122260
144Pendular nystagmus (HP:0012043)1.74637915
145Chronic hepatic failure (HP:0100626)1.74456540
146Fibular hypoplasia (HP:0003038)1.74164738
147Occipital encephalocele (HP:0002085)1.73979041
148Optic nerve hypoplasia (HP:0000609)1.73528716
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73328509
150Sclerocornea (HP:0000647)1.72581301
151Resting tremor (HP:0002322)1.72228427
152Pointed chin (HP:0000307)1.72083130
153Delayed gross motor development (HP:0002194)1.72039704
154Lipid accumulation in hepatocytes (HP:0006561)1.71973414
155Overgrowth (HP:0001548)1.71471981
156Hypercortisolism (HP:0001578)1.71278607
157Bilateral microphthalmos (HP:0007633)1.71167454
158Bradykinesia (HP:0002067)1.69827767
159Prolonged QT interval (HP:0001657)1.69600010
160Hepatocellular necrosis (HP:0001404)1.69042094
161Aplasia/Hypoplasia of the fibula (HP:0006492)1.68723262
162Retinal atrophy (HP:0001105)1.68698535
163Increased variability in muscle fiber diameter (HP:0003557)1.67863459
164Prominent supraorbital ridges (HP:0000336)1.67850831
165Hepatoblastoma (HP:0002884)1.67742584
166Neuronal loss in central nervous system (HP:0002529)1.67226894
167Postural instability (HP:0002172)1.67009199
168Sleep apnea (HP:0010535)1.66852059
169Palpebral edema (HP:0100540)1.66717340
170Impaired pain sensation (HP:0007328)1.65451158
171Abnormality of pain sensation (HP:0010832)1.65451158
172Flat capital femoral epiphysis (HP:0003370)1.65122899
173Metabolic alkalosis (HP:0200114)1.64677352
174Abnormal hair whorl (HP:0010721)1.64355416
175Attenuation of retinal blood vessels (HP:0007843)1.64185082
176Morphological abnormality of the middle ear (HP:0008609)1.63959683
177Long toe (HP:0010511)1.63648988
178Humeroradial synostosis (HP:0003041)1.63100100
179Synostosis involving the elbow (HP:0003938)1.63100100
180Incomplete penetrance (HP:0003829)1.61877322
181Hyperkalemia (HP:0002153)1.61465298
182Abnormality of the labia minora (HP:0012880)1.61405374
183Impaired vibratory sensation (HP:0002495)1.60853540
184Shallow orbits (HP:0000586)1.60770714
185Aortic dissection (HP:0002647)1.59372214
186Absent speech (HP:0001344)1.58300579
187Accelerated skeletal maturation (HP:0005616)1.58295446
188Hyperextensible skin (HP:0000974)1.55166382
189Abnormality of saccadic eye movements (HP:0000570)1.53361878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK34.11006043
2NTRK33.76004922
3EPHA43.58781942
4MAP3K93.11460429
5MAP3K122.99081728
6MINK12.83978918
7MAP3K42.74227731
8MAP4K22.66342027
9KSR12.61579541
10LATS22.36530839
11ADRBK22.33214464
12ARAF2.28086877
13KSR22.20548349
14GRK12.09969461
15MAP2K72.09528715
16MAP2K42.03038060
17BCR1.96598075
18TIE11.93774654
19OXSR11.93762759
20AKT31.91905280
21MUSK1.86862068
22INSRR1.84967564
23BMPR1B1.81827518
24PLK21.69820250
25PIK3CA1.69526332
26MAPKAPK31.68846959
27PTK2B1.58735915
28CASK1.57346024
29DDR21.56677213
30CAMKK11.53714891
31TAOK31.51074440
32NTRK11.50104005
33GRK51.45822266
34MARK11.45328284
35SIK21.43518958
36ZAK1.42009228
37PNCK1.37726460
38DAPK21.37194067
39NUAK11.31030954
40EIF2AK31.30995585
41PRKD31.30734285
42MYLK1.30183491
43NME11.28392856
44PAK61.26333573
45RIPK41.26063778
46TRIM281.25526264
47FER1.24965066
48DYRK21.21349436
49SCYL21.20327895
50NLK1.18376330
51TAOK11.18133405
52CDK51.15483033
53PRKCG1.13950524
54MAPK151.12533944
55STK381.12315077
56NTRK21.12000476
57DAPK11.10974594
58BRSK21.09539870
59VRK21.05684913
60CAMK2A1.04109868
61CSNK1G11.02763939
62PRKCI1.02734377
63ACVR1B1.01013731
64WNK30.97987684
65MAP3K20.95048946
66PAK30.94327907
67TLK10.94074669
68SGK20.93377677
69CDK180.93221502
70SGK2230.92021213
71SGK4940.92021213
72WNK40.91889082
73PDGFRA0.91574876
74PHKG20.90787133
75PHKG10.90787133
76VRK10.90314939
77MAP3K130.89579595
78SGK30.86098112
79UHMK10.81342217
80NEK60.79795878
81PRKCH0.79449263
82CDK140.76485206
83CHUK0.74486831
84BCKDK0.73976995
85MAPK130.73242358
86CAMK2B0.70864165
87CDK150.70850639
88RAF10.69660688
89TRIB30.68423183
90ERBB30.68330810
91CAMKK20.68287081
92CSNK1G30.68084716
93WEE10.66948833
94BMPR20.66933902
95SRPK10.66908064
96CDK30.66770747
97NEK10.66748247
98TNK20.66733706
99MAP2K10.64444240
100RET0.64263297
101EPHB20.61841444
102CAMK2G0.61252174
103MAP3K10.60827104
104CSNK1A10.60446440
105PINK10.59957152
106LMTK20.59947850
107EIF2AK10.59728992
108CAMK10.57205807
109CSNK1G20.56497766
110PRKAA20.56025196
111CDK11A0.55347215
112TYRO30.54793858
113MOS0.54615514
114TNIK0.54354732
115HIPK20.54088750
116SGK10.53643626
117FGFR20.53571391
118PDK40.53169385
119PDK30.53169385
120LIMK10.52884780
121CAMK1G0.52406777
122PRKCE0.52036943
123MAP2K20.51696258
124CAMK40.51098503
125ERBB40.50848272
126RPS6KB10.50666514
127EIF2AK20.50504976
128CSNK1A1L0.50226836
129STK38L0.49002564
130NEK20.48071100
131TESK10.47919752
132FES0.47688283
133MKNK20.47556521
134PRKCZ0.47059607
135BRAF0.46622591
136EPHA30.45625650
137LATS10.44712208
138FRK0.44331505
139GRK70.42458653
140STK110.41688287
141WNK10.41550428
142RPS6KA30.40808616
143RPS6KA50.40795669
144ADRBK10.40395043
145MAPKAPK50.39422820
146SIK10.39418047
147PRKG10.38959522
148MAP2K60.38939809
149CAMK2D0.38908936
150DYRK1A0.38490339
151PRKACA0.38305064
152CDC42BPA0.37216524
153PRPF4B0.36101947
154STK390.35618570

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.13513350
2Synaptic vesicle cycle_Homo sapiens_hsa047213.02670513
3Amphetamine addiction_Homo sapiens_hsa050312.76942438
4Phototransduction_Homo sapiens_hsa047442.72946071
5Aldosterone synthesis and secretion_Homo sapiens_hsa049252.60303703
6Olfactory transduction_Homo sapiens_hsa047402.53608326
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47480000
8Cocaine addiction_Homo sapiens_hsa050302.45448720
9GABAergic synapse_Homo sapiens_hsa047272.29553838
10Circadian entrainment_Homo sapiens_hsa047132.26369024
11Long-term potentiation_Homo sapiens_hsa047202.18117406
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16219139
13Morphine addiction_Homo sapiens_hsa050322.13479897
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12875061
15Collecting duct acid secretion_Homo sapiens_hsa049662.06550735
16Dopaminergic synapse_Homo sapiens_hsa047282.04156837
17Protein export_Homo sapiens_hsa030602.02608870
18Glutamatergic synapse_Homo sapiens_hsa047241.90175243
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.85747696
20Linoleic acid metabolism_Homo sapiens_hsa005911.77070961
21Tryptophan metabolism_Homo sapiens_hsa003801.76726915
22Salivary secretion_Homo sapiens_hsa049701.67444061
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66106901
24Renin secretion_Homo sapiens_hsa049241.63401740
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60467080
26Cholinergic synapse_Homo sapiens_hsa047251.59668112
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57641888
28Serotonergic synapse_Homo sapiens_hsa047261.53359064
29Calcium signaling pathway_Homo sapiens_hsa040201.51440997
30Ovarian steroidogenesis_Homo sapiens_hsa049131.47990947
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.45969399
32Vibrio cholerae infection_Homo sapiens_hsa051101.45769296
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45193256
34Selenocompound metabolism_Homo sapiens_hsa004501.44214804
35Insulin secretion_Homo sapiens_hsa049111.43574257
36Gastric acid secretion_Homo sapiens_hsa049711.43401284
37Histidine metabolism_Homo sapiens_hsa003401.38463576
38Gap junction_Homo sapiens_hsa045401.36188035
39Long-term depression_Homo sapiens_hsa047301.36033604
40beta-Alanine metabolism_Homo sapiens_hsa004101.29314017
41Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29286055
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28695807
43Oxytocin signaling pathway_Homo sapiens_hsa049211.26795074
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26072412
45GnRH signaling pathway_Homo sapiens_hsa049121.25495210
46Taste transduction_Homo sapiens_hsa047421.23391978
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22693371
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.21154948
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20642972
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17915443
51cAMP signaling pathway_Homo sapiens_hsa040241.14414425
52Oxidative phosphorylation_Homo sapiens_hsa001901.13591591
53Chemical carcinogenesis_Homo sapiens_hsa052041.13475713
54Circadian rhythm_Homo sapiens_hsa047101.12725748
55ABC transporters_Homo sapiens_hsa020101.12407119
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11940187
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11885182
58Nitrogen metabolism_Homo sapiens_hsa009101.09180064
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06206211
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05780601
61Melanogenesis_Homo sapiens_hsa049161.05318115
62Fatty acid elongation_Homo sapiens_hsa000621.04175437
63Parkinsons disease_Homo sapiens_hsa050121.03924737
64Fanconi anemia pathway_Homo sapiens_hsa034601.02943691
65Ether lipid metabolism_Homo sapiens_hsa005651.02423922
66Basal transcription factors_Homo sapiens_hsa030221.00328666
67Vascular smooth muscle contraction_Homo sapiens_hsa042700.95189761
68Arginine biosynthesis_Homo sapiens_hsa002200.93237850
69Cardiac muscle contraction_Homo sapiens_hsa042600.92993620
70Axon guidance_Homo sapiens_hsa043600.92210396
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90919127
72Estrogen signaling pathway_Homo sapiens_hsa049150.90738303
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90641571
74Dilated cardiomyopathy_Homo sapiens_hsa054140.90403348
75RNA polymerase_Homo sapiens_hsa030200.90025999
76Caffeine metabolism_Homo sapiens_hsa002320.89687966
77Homologous recombination_Homo sapiens_hsa034400.88670939
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88643708
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86070891
80Tyrosine metabolism_Homo sapiens_hsa003500.85050870
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84771507
82Alzheimers disease_Homo sapiens_hsa050100.84682981
83Fatty acid degradation_Homo sapiens_hsa000710.83747354
84Peroxisome_Homo sapiens_hsa041460.83276250
85Glioma_Homo sapiens_hsa052140.82853098
86Cyanoamino acid metabolism_Homo sapiens_hsa004600.81233324
87Butanoate metabolism_Homo sapiens_hsa006500.80534984
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80388825
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80161656
90Bile secretion_Homo sapiens_hsa049760.79738192
91One carbon pool by folate_Homo sapiens_hsa006700.78732625
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78268469
93Sulfur metabolism_Homo sapiens_hsa009200.77529779
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77019661
95Regulation of autophagy_Homo sapiens_hsa041400.77017014
96Thyroid hormone synthesis_Homo sapiens_hsa049180.74499649
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72536212
98Proteasome_Homo sapiens_hsa030500.72310429
99Oocyte meiosis_Homo sapiens_hsa041140.70352867
100Pyruvate metabolism_Homo sapiens_hsa006200.68961071
101Glucagon signaling pathway_Homo sapiens_hsa049220.67995237
102RNA degradation_Homo sapiens_hsa030180.67775690
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67746082
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65753108
105Arachidonic acid metabolism_Homo sapiens_hsa005900.63004188
106ECM-receptor interaction_Homo sapiens_hsa045120.61569497
107Phenylalanine metabolism_Homo sapiens_hsa003600.61211477
108Metabolic pathways_Homo sapiens_hsa011000.59493538
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59434080
110Retinol metabolism_Homo sapiens_hsa008300.59299706
111TGF-beta signaling pathway_Homo sapiens_hsa043500.58654463
112ErbB signaling pathway_Homo sapiens_hsa040120.56786607
113Sphingolipid metabolism_Homo sapiens_hsa006000.55761954
114Vitamin B6 metabolism_Homo sapiens_hsa007500.55158339
115Purine metabolism_Homo sapiens_hsa002300.54732949
116Dorso-ventral axis formation_Homo sapiens_hsa043200.54683467
117Glycerolipid metabolism_Homo sapiens_hsa005610.53897934
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53155042
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52081703
120Wnt signaling pathway_Homo sapiens_hsa043100.52048257
121Hedgehog signaling pathway_Homo sapiens_hsa043400.50829211
122Mineral absorption_Homo sapiens_hsa049780.49207827
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49009523
124Rap1 signaling pathway_Homo sapiens_hsa040150.48792008
125Type II diabetes mellitus_Homo sapiens_hsa049300.48008872
126Prion diseases_Homo sapiens_hsa050200.47403836
127Huntingtons disease_Homo sapiens_hsa050160.46339865
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.45279571
129Glutathione metabolism_Homo sapiens_hsa004800.45125450
130Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44778807
131Rheumatoid arthritis_Homo sapiens_hsa053230.43074610
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.41926910
133Lysine degradation_Homo sapiens_hsa003100.41088864
134Phagosome_Homo sapiens_hsa041450.40957788
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40893101
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40753416
137Hippo signaling pathway_Homo sapiens_hsa043900.39684162
138MAPK signaling pathway_Homo sapiens_hsa040100.38686624
139Ras signaling pathway_Homo sapiens_hsa040140.37887030
140Choline metabolism in cancer_Homo sapiens_hsa052310.37136452
141Alcoholism_Homo sapiens_hsa050340.35022612
142Focal adhesion_Homo sapiens_hsa045100.34786701
143Type I diabetes mellitus_Homo sapiens_hsa049400.31031482
144Amoebiasis_Homo sapiens_hsa051460.30697720
145Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29896864
146Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29597836
147Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29315739
148African trypanosomiasis_Homo sapiens_hsa051430.29058909
149Pancreatic secretion_Homo sapiens_hsa049720.28912657
150Fatty acid metabolism_Homo sapiens_hsa012120.27335950
151Protein digestion and absorption_Homo sapiens_hsa049740.27032309
152Propanoate metabolism_Homo sapiens_hsa006400.26404461

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