REST

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.54131622
2nuclear pore organization (GO:0006999)5.38253581
3mitotic metaphase plate congression (GO:0007080)4.67862807
4protein localization to kinetochore (GO:0034501)4.37315156
5regulation of gene silencing by RNA (GO:0060966)4.32541697
6regulation of posttranscriptional gene silencing (GO:0060147)4.32541697
7regulation of gene silencing by miRNA (GO:0060964)4.32541697
8pore complex assembly (GO:0046931)4.27711028
9negative regulation of DNA repair (GO:0045738)4.12330232
10metaphase plate congression (GO:0051310)4.09363455
11mitotic nuclear envelope disassembly (GO:0007077)4.09078280
12DNA replication-dependent nucleosome organization (GO:0034723)4.03562468
13DNA replication-dependent nucleosome assembly (GO:0006335)4.03562468
14regulation of spindle organization (GO:0090224)4.02351250
15regulation of helicase activity (GO:0051095)3.96974302
16DNA replication initiation (GO:0006270)3.94448754
17membrane disassembly (GO:0030397)3.79583116
18nuclear envelope disassembly (GO:0051081)3.79583116
19kinetochore organization (GO:0051383)3.78223236
20protein localization to chromosome, centromeric region (GO:0071459)3.71951076
21protein K6-linked ubiquitination (GO:0085020)3.69938359
22regulation of mitotic spindle organization (GO:0060236)3.67388590
23mitotic chromosome condensation (GO:0007076)3.67181342
24DNA replication checkpoint (GO:0000076)3.65543972
25IMP biosynthetic process (GO:0006188)3.58527219
26regulation of histone H3-K9 methylation (GO:0051570)3.56852989
27establishment of chromosome localization (GO:0051303)3.55440128
28DNA unwinding involved in DNA replication (GO:0006268)3.54816919
29chromatin remodeling at centromere (GO:0031055)3.51555353
30positive regulation of chromosome segregation (GO:0051984)3.50129258
31meiotic chromosome segregation (GO:0045132)3.48885520
32kinetochore assembly (GO:0051382)3.47468442
33mitotic sister chromatid cohesion (GO:0007064)3.47301638
34mitotic G2/M transition checkpoint (GO:0044818)3.46000316
35double-strand break repair via nonhomologous end joining (GO:0006303)3.45213091
36non-recombinational repair (GO:0000726)3.45213091
37nucleobase biosynthetic process (GO:0046112)3.43500547
38negative regulation of histone methylation (GO:0031061)3.41230331
39ribosome assembly (GO:0042255)3.39284567
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38636812
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37411060
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.37411060
43CENP-A containing nucleosome assembly (GO:0034080)3.37362893
44purine nucleobase biosynthetic process (GO:0009113)3.35464555
45attachment of spindle microtubules to kinetochore (GO:0008608)3.33087086
46DNA strand elongation involved in DNA replication (GO:0006271)3.32999277
47positive regulation of mitotic sister chromatid separation (GO:1901970)3.32337529
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32337529
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32337529
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.31530346
51DNA replication-independent nucleosome organization (GO:0034724)3.30427501
52DNA replication-independent nucleosome assembly (GO:0006336)3.30427501
53regulation of gene silencing (GO:0060968)3.28071804
54mitotic G2 DNA damage checkpoint (GO:0007095)3.27408541
55negative regulation of fibroblast apoptotic process (GO:2000270)3.26552809
56mitotic sister chromatid segregation (GO:0000070)3.24859569
57positive regulation of SMAD protein import into nucleus (GO:0060391)3.23256423
58IMP metabolic process (GO:0046040)3.23228428
59regulation of RNA export from nucleus (GO:0046831)3.20010661
60DNA double-strand break processing (GO:0000729)3.19362684
61establishment of integrated proviral latency (GO:0075713)3.19246247
62DNA strand elongation (GO:0022616)3.19191714
63regulation of sister chromatid cohesion (GO:0007063)3.19032171
64heterochromatin organization (GO:0070828)3.18107641
65DNA geometric change (GO:0032392)3.17836577
66histone H2A monoubiquitination (GO:0035518)3.17465357
67DNA duplex unwinding (GO:0032508)3.17083546
68synapsis (GO:0007129)3.16930579
69folic acid-containing compound biosynthetic process (GO:0009396)3.16559394
70maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14905407
71regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.14720884
72negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.13123018
73negative regulation of translation, ncRNA-mediated (GO:0040033)3.13123018
74regulation of translation, ncRNA-mediated (GO:0045974)3.13123018
75paraxial mesoderm development (GO:0048339)3.13069509
76ribosome biogenesis (GO:0042254)3.11688136
77pre-miRNA processing (GO:0031054)3.11381741
78DNA topological change (GO:0006265)3.08730849
79spindle checkpoint (GO:0031577)3.08564666
80sister chromatid segregation (GO:0000819)3.08303306
81DNA ligation (GO:0006266)3.07869190
82response to X-ray (GO:0010165)3.07059268
83telomere maintenance via semi-conservative replication (GO:0032201)3.06643375
84chromatin assembly or disassembly (GO:0006333)3.06060573
85regulation of chromosome segregation (GO:0051983)3.04791494
86regulation of centrosome cycle (GO:0046605)3.04463175
87histone exchange (GO:0043486)3.03470834
88telomere maintenance via recombination (GO:0000722)3.02438310
89maturation of SSU-rRNA (GO:0030490)3.01817651
90protein localization to chromosome (GO:0034502)3.01488632
91chromatin assembly (GO:0031497)3.01373013
92regulation of DNA endoreduplication (GO:0032875)3.00572072
93mitotic recombination (GO:0006312)3.00234663
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99464541
95regulation of centrosome duplication (GO:0010824)2.98186386
96regulation of nuclear cell cycle DNA replication (GO:0033262)2.98183809
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96681669
98regulation of chromatin silencing (GO:0031935)2.95294900
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.95291353
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94390290
101formation of translation preinitiation complex (GO:0001731)2.92909064
102negative regulation of chromosome segregation (GO:0051985)2.90608559
103DNA synthesis involved in DNA repair (GO:0000731)2.90442343
104histone mRNA catabolic process (GO:0071044)2.90080375
105mismatch repair (GO:0006298)2.89624264
106nuclear envelope organization (GO:0006998)2.88772716
107sister chromatid cohesion (GO:0007062)2.88678834
108regulation of telomere maintenance via telomerase (GO:0032210)2.88649312
109mitotic spindle checkpoint (GO:0071174)2.85909069
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85879357
111chromosome segregation (GO:0007059)2.85754900
112inner cell mass cell proliferation (GO:0001833)2.84859437
113negative regulation of mitotic sister chromatid separation (GO:2000816)2.83475034
114negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83475034
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83475034
116negative regulation of sister chromatid segregation (GO:0033046)2.83475034
117spindle assembly checkpoint (GO:0071173)2.82254359
118monoubiquitinated protein deubiquitination (GO:0035520)2.81332263
119regulation of centriole replication (GO:0046599)2.81287901
120regulation of sister chromatid segregation (GO:0033045)2.81195725
121regulation of mitotic sister chromatid separation (GO:0010965)2.81195725
122regulation of mitotic sister chromatid segregation (GO:0033047)2.81195725
123maturation of 5.8S rRNA (GO:0000460)2.80699628
124telomere maintenance via telomere lengthening (GO:0010833)2.80168180
125replication fork processing (GO:0031297)2.80027028
126ATP-dependent chromatin remodeling (GO:0043044)2.80000274
127negative regulation of DNA-dependent DNA replication (GO:2000104)2.79754756
128notochord development (GO:0030903)2.76495203
129mitotic spindle assembly checkpoint (GO:0007094)2.75213990
130genitalia morphogenesis (GO:0035112)2.66649045
131centriole replication (GO:0007099)2.66579718
132histone mRNA metabolic process (GO:0008334)2.64751052
133RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.62558724
134anterior/posterior axis specification, embryo (GO:0008595)2.60864185
135definitive hemopoiesis (GO:0060216)2.58069503

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.81191371
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.72660368
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.92771011
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.54408309
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.25999067
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.89633529
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66809783
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52939575
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45626963
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.44951296
11NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30668805
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28623524
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28623524
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28623524
15AR_21909140_ChIP-Seq_LNCAP_Human2.24634759
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23606717
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.21095478
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.16405899
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.13187013
20MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12707687
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12405006
22NANOG_18555785_ChIP-Seq_MESCs_Mouse2.07215311
23* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.05074970
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98188069
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96707957
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96063032
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.88919546
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.87944601
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84914685
30EWS_26573619_Chip-Seq_HEK293_Human1.84019532
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81933373
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78628565
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78553219
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.78191611
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.75499678
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.72023247
37* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68849224
38XRN2_22483619_ChIP-Seq_HELA_Human1.66969715
39VDR_23849224_ChIP-Seq_CD4+_Human1.66243853
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63248138
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.62737116
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.62049774
43SOX2_18555785_ChIP-Seq_MESCs_Mouse1.60234025
44* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57083275
45* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54947715
46FUS_26573619_Chip-Seq_HEK293_Human1.49965094
47* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48327122
48ELK1_19687146_ChIP-ChIP_HELA_Human1.47649779
49* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47568155
50SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.47123036
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44216958
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44051314
53* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.42145421
54MYC_22102868_ChIP-Seq_BL_Human1.41247836
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36257394
56FOXP3_21729870_ChIP-Seq_TREG_Human1.35653538
57WT1_19549856_ChIP-ChIP_CCG9911_Human1.35299075
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35033242
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.34742225
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34454139
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33118209
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.29869393
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28570449
64* NANOG_16153702_ChIP-ChIP_HESCs_Human1.28222676
65TTF2_22483619_ChIP-Seq_HELA_Human1.27847471
66KDM5A_27292631_Chip-Seq_BREAST_Human1.26992407
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26665966
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26105095
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25116198
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22677402
71DCP1A_22483619_ChIP-Seq_HELA_Human1.21869628
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21825448
73TAF15_26573619_Chip-Seq_HEK293_Human1.21777948
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21194380
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20527078
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19700730
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.17221435
78FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16801601
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16538400
80* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16378622
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14940377
82NANOG_21062744_ChIP-ChIP_HESCs_Human1.13513826
83GABP_19822575_ChIP-Seq_HepG2_Human1.13192222
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13152051
85* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10813013
86TFEB_21752829_ChIP-Seq_HELA_Human1.10444970
87* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.09408971
88BRD4_25478319_ChIP-Seq_HGPS_Human1.09313791
89FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08096918
90P300_19829295_ChIP-Seq_ESCs_Human1.07907576
91CIITA_25753668_ChIP-Seq_RAJI_Human1.07834989
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07087463
93* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06704495
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.05582444
95* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04964293
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.04354750
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03590363
98* SOX2_16153702_ChIP-ChIP_HESCs_Human1.03327871
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01672954
100* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01276945
101ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01242644
102FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99810344
103* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99636101
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99027756
105HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98349255
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97993028
107* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97704082
108SMAD_19615063_ChIP-ChIP_OVARY_Human0.97517475
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95322771
110MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94931178
111* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.94850861
112* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94452636
113* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93790840
114* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93048666
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91401502
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.90928190
117* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90696208
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87779207
119* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87569188
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.87135814
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.87115935
122* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86767668
123HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86586549
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85711986
125FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.85523355
126MYC_18940864_ChIP-ChIP_HL60_Human0.85175559
127* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.84961385
128GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84096311
129CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83647022
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.83173503
131TBX3_20139965_ChIP-Seq_ESCs_Mouse0.83130240
132THAP11_20581084_ChIP-Seq_MESCs_Mouse0.82982503
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82396493
134EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82196540
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.82117217
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.81315486
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.80321906
138ZNF274_21170338_ChIP-Seq_K562_Hela0.80180294
139IGF1R_20145208_ChIP-Seq_DFB_Human0.75134627
140GATA1_22025678_ChIP-Seq_K562_Human0.75123936
141MYB_26560356_Chip-Seq_TH2_Human0.74396266
142* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.73962790

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.13097110
2MP0003693_abnormal_embryo_hatching4.05780929
3MP0010094_abnormal_chromosome_stability3.91908964
4MP0003111_abnormal_nucleus_morphology3.65924005
5MP0004957_abnormal_blastocyst_morpholog3.50464429
6MP0003077_abnormal_cell_cycle3.45357779
7MP0008058_abnormal_DNA_repair2.72374860
8MP0010352_gastrointestinal_tract_polyps2.66189574
9MP0008007_abnormal_cellular_replicative2.57645941
10MP0010307_abnormal_tumor_latency2.45671510
11MP0009697_abnormal_copulation2.44085164
12MP0003123_paternal_imprinting2.33473566
13MP0000350_abnormal_cell_proliferation2.22432405
14MP0001730_embryonic_growth_arrest2.15495836
15MP0002009_preneoplasia1.99906694
16MP0005076_abnormal_cell_differentiation1.98985260
17MP0008877_abnormal_DNA_methylation1.93937537
18MP0008932_abnormal_embryonic_tissue1.92621746
19MP0002396_abnormal_hematopoietic_system1.85906367
20* MP0005380_embryogenesis_phenotype1.80021354
21* MP0001672_abnormal_embryogenesis/_devel1.80021354
22MP0000383_abnormal_hair_follicle1.76693594
23MP0006054_spinal_hemorrhage1.71508057
24MP0001697_abnormal_embryo_size1.66624276
25MP0002084_abnormal_developmental_patter1.65187494
26MP0002086_abnormal_extraembryonic_tissu1.64805408
27MP0002254_reproductive_system_inflammat1.64447016
28* MP0002085_abnormal_embryonic_tissue1.61822596
29MP0003786_premature_aging1.61644877
30* MP0003984_embryonic_growth_retardation1.59836866
31* MP0002088_abnormal_embryonic_growth/wei1.56830664
32MP0010678_abnormal_skin_adnexa1.55259268
33MP0004197_abnormal_fetal_growth/weight/1.54187374
34MP0003941_abnormal_skin_development1.52023277
35MP0001293_anophthalmia1.51872415
36MP0003718_maternal_effect1.48246819
37MP0003705_abnormal_hypodermis_morpholog1.47195716
38MP0002233_abnormal_nose_morphology1.37921188
39MP0000490_abnormal_crypts_of1.37634575
40MP0003567_abnormal_fetal_cardiomyocyte1.37009011
41* MP0002080_prenatal_lethality1.34755309
42MP0003121_genomic_imprinting1.33947284
43MP0003890_abnormal_embryonic-extraembry1.32389457
44MP0009053_abnormal_anal_canal1.29007415
45MP0004808_abnormal_hematopoietic_stem1.28254540
46MP0003566_abnormal_cell_adhesion1.25537148
47MP0002796_impaired_skin_barrier1.22392431
48MP0000516_abnormal_urinary_system1.20656465
49MP0005367_renal/urinary_system_phenotyp1.20656465
50MP0002019_abnormal_tumor_incidence1.20287084
51MP0001545_abnormal_hematopoietic_system1.19241179
52MP0005397_hematopoietic_system_phenotyp1.19241179
53MP0003937_abnormal_limbs/digits/tail_de1.17560429
54* MP0000313_abnormal_cell_death1.13433352
55MP0002210_abnormal_sex_determination1.13263968
56MP0010030_abnormal_orbit_morphology1.12247609
57MP0000569_abnormal_digit_pigmentation1.09594078
58MP0005023_abnormal_wound_healing1.07322625
59MP0003943_abnormal_hepatobiliary_system1.04398194
60MP0004272_abnormal_basement_membrane1.02476209
61MP0000566_synostosis1.02398639
62MP0002938_white_spotting0.99903155
63MP0001915_intracranial_hemorrhage0.99681714
64MP0003806_abnormal_nucleotide_metabolis0.99276423
65MP0005248_abnormal_Harderian_gland0.98941092
66MP0003315_abnormal_perineum_morphology0.97865474
67MP0001145_abnormal_male_reproductive0.97529667
68MP0001119_abnormal_female_reproductive0.95368684
69MP0009278_abnormal_bone_marrow0.95233551
70MP0006292_abnormal_olfactory_placode0.94983872
71MP0002282_abnormal_trachea_morphology0.94588191
72MP0002877_abnormal_melanocyte_morpholog0.92954431
73MP0000432_abnormal_head_morphology0.91757896
74MP0003448_altered_tumor_morphology0.91637133
75MP0003119_abnormal_digestive_system0.90169824
76MP0001849_ear_inflammation0.89786951
77MP0000653_abnormal_sex_gland0.86280507
78MP0009333_abnormal_splenocyte_physiolog0.85568910
79MP0004264_abnormal_extraembryonic_tissu0.84933064
80MP0005501_abnormal_skin_physiology0.84803771
81MP0002092_abnormal_eye_morphology0.84372892
82MP0003385_abnormal_body_wall0.83548276
83MP0003136_yellow_coat_color0.82843585
84MP0001929_abnormal_gametogenesis0.82749442
85MP0002111_abnormal_tail_morphology0.82627608
86MP0000428_abnormal_craniofacial_morphol0.82041890
87MP0002653_abnormal_ependyma_morphology0.81548035
88MP0002006_tumorigenesis0.81246493
89MP0005621_abnormal_cell_physiology0.80215792
90MP0000733_abnormal_muscle_development0.80092892
91MP0004133_heterotaxia0.79635100
92MP0002098_abnormal_vibrissa_morphology0.79593545
93MP0001661_extended_life_span0.79406890
94MP0009703_decreased_birth_body0.79305113
95MP0000858_altered_metastatic_potential0.79241282
96MP0009384_cardiac_valve_regurgitation0.78691282
97MP0002925_abnormal_cardiovascular_devel0.77961857
98MP0000703_abnormal_thymus_morphology0.76478635
99MP0010234_abnormal_vibrissa_follicle0.76346413
100MP0000537_abnormal_urethra_morphology0.75931130
101MP0002398_abnormal_bone_marrow0.75361244
102MP0000627_abnormal_mammary_gland0.74519471
103MP0001853_heart_inflammation0.74497964
104MP0001879_abnormal_lymphatic_vessel0.74074962
105MP0002697_abnormal_eye_size0.73960387
106MP0003936_abnormal_reproductive_system0.73536407
107MP0005275_abnormal_skin_tensile0.72846883
108* MP0001286_abnormal_eye_development0.72825114
109MP0003950_abnormal_plasma_membrane0.72588055
110MP0010630_abnormal_cardiac_muscle0.71370073
111MP0001177_atelectasis0.71020613
112MP0002722_abnormal_immune_system0.70769283
113MP0002102_abnormal_ear_morphology0.70708639
114MP0003453_abnormal_keratinocyte_physiol0.70516413
115MP0000689_abnormal_spleen_morphology0.70150931
116MP0009672_abnormal_birth_weight0.69977153
117MP0005384_cellular_phenotype0.69814918
118MP0000465_gastrointestinal_hemorrhage0.68325456
119MP0000647_abnormal_sebaceous_gland0.68207916
120MP0001784_abnormal_fluid_regulation0.67934228
121MP0001299_abnormal_eye_distance/0.67743183
122MP0003763_abnormal_thymus_physiology0.66412449
123MP0003935_abnormal_craniofacial_develop0.66145914
124MP0003755_abnormal_palate_morphology0.65519296
125MP0002160_abnormal_reproductive_system0.63346033
126MP0004185_abnormal_adipocyte_glucose0.61836733
127MP0000477_abnormal_intestine_morphology0.61532343
128MP0005395_other_phenotype0.60630393
129MP0003828_pulmonary_edema0.60186520
130MP0002249_abnormal_larynx_morphology0.58841046

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.39184177
2Birth length less than 3rd percentile (HP:0003561)4.21215952
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.10033087
4Ependymoma (HP:0002888)3.54626201
5Breast hypoplasia (HP:0003187)3.52402043
6Abnormality of the labia minora (HP:0012880)3.48526909
7Medulloblastoma (HP:0002885)3.43661539
8Abnormality of chromosome stability (HP:0003220)3.21106580
9Agnosia (HP:0010524)3.17463270
10Patellar aplasia (HP:0006443)3.12453574
11Supernumerary spleens (HP:0009799)3.05588456
12Absent radius (HP:0003974)2.95677487
13Meckel diverticulum (HP:0002245)2.95655100
14Selective tooth agenesis (HP:0001592)2.92478390
15Rhabdomyosarcoma (HP:0002859)2.91382424
16Neoplasm of the oral cavity (HP:0100649)2.91052783
17Aplasia/Hypoplasia of the patella (HP:0006498)2.89619624
18Impulsivity (HP:0100710)2.86324772
19Colon cancer (HP:0003003)2.85807566
20Ectopic kidney (HP:0000086)2.83484883
21Abnormality of the ileum (HP:0001549)2.78372575
22Papillary thyroid carcinoma (HP:0002895)2.78109589
23Aplasia involving forearm bones (HP:0009822)2.75237007
24Absent forearm bone (HP:0003953)2.75237007
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.73681335
26Short middle phalanx of the 5th finger (HP:0004220)2.71927519
27Abnormality of the preputium (HP:0100587)2.71224986
28Carpal bone hypoplasia (HP:0001498)2.68241291
29Biliary tract neoplasm (HP:0100574)2.47657032
30Abnormality of the astrocytes (HP:0100707)2.47329142
31Astrocytoma (HP:0009592)2.47329142
32Shawl scrotum (HP:0000049)2.46843962
33Myelodysplasia (HP:0002863)2.43560140
34Aplasia/hypoplasia of the humerus (HP:0006507)2.39761813
35Reticulocytopenia (HP:0001896)2.36172305
36Facial hemangioma (HP:0000329)2.33903200
37Duodenal stenosis (HP:0100867)2.32836403
38Small intestinal stenosis (HP:0012848)2.32836403
39Deviation of the thumb (HP:0009603)2.31194782
40Glioma (HP:0009733)2.29978754
41Absent thumb (HP:0009777)2.29097475
42Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28880817
43Short 4th metacarpal (HP:0010044)2.28880817
44Short humerus (HP:0005792)2.25387528
45Amaurosis fugax (HP:0100576)2.23982763
46Proximal placement of thumb (HP:0009623)2.22821190
47Neoplasm of striated muscle (HP:0009728)2.21968528
48Bifid tongue (HP:0010297)2.21237101
49Abnormality of the fingertips (HP:0001211)2.20039399
50Bilateral microphthalmos (HP:0007633)2.16498575
51Rib fusion (HP:0000902)2.16056905
52Deep philtrum (HP:0002002)2.16032119
53Skull defect (HP:0001362)2.15983180
54Neoplasm of the pancreas (HP:0002894)2.13362957
55Short thumb (HP:0009778)2.12343100
56Acute myeloid leukemia (HP:0004808)2.12267275
57Volvulus (HP:0002580)2.10510282
58Abnormality of the anterior horn cell (HP:0006802)2.07881718
59Degeneration of anterior horn cells (HP:0002398)2.07881718
60Tracheoesophageal fistula (HP:0002575)2.07305811
61Basal cell carcinoma (HP:0002671)2.06918342
62Oral leukoplakia (HP:0002745)2.06808679
63Missing ribs (HP:0000921)2.02811704
64Sloping forehead (HP:0000340)2.01969040
65Abnormal number of incisors (HP:0011064)2.01504511
66Nephroblastoma (Wilms tumor) (HP:0002667)2.01361202
67Long eyelashes (HP:0000527)1.99604803
68Sparse lateral eyebrow (HP:0005338)1.99211981
69Malignant gastrointestinal tract tumors (HP:0006749)1.98759637
70Gastrointestinal carcinoma (HP:0002672)1.98759637
71Short middle phalanx of finger (HP:0005819)1.98184003
72Long nose (HP:0003189)1.98113336
73Prostate neoplasm (HP:0100787)1.97573900
74Prominent nose (HP:0000448)1.96876745
75Abnormality of the duodenum (HP:0002246)1.96306044
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.95319092
77Intestinal fistula (HP:0100819)1.94963307
78Atresia of the external auditory canal (HP:0000413)1.94678979
79Bone marrow hypocellularity (HP:0005528)1.94199475
80B lymphocytopenia (HP:0010976)1.93889242
81Duplication of thumb phalanx (HP:0009942)1.93828128
82Abnormal hair whorl (HP:0010721)1.93682857
83Gonadotropin excess (HP:0000837)1.92192548
84Abnormality of the septum pellucidum (HP:0007375)1.92159271
85Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91696974
86Clubbing of toes (HP:0100760)1.91633876
87Cafe-au-lait spot (HP:0000957)1.91561843
88Septo-optic dysplasia (HP:0100842)1.91396243
89Supernumerary bones of the axial skeleton (HP:0009144)1.91031568
90Preaxial foot polydactyly (HP:0001841)1.90678087
91Rough bone trabeculation (HP:0100670)1.89667357
92Supernumerary ribs (HP:0005815)1.89585703
93Abnormality of the parietal bone (HP:0002696)1.89253512
94Rectal fistula (HP:0100590)1.89133511
95Rectovaginal fistula (HP:0000143)1.89133511
96Median cleft lip (HP:0000161)1.89007535
97Embryonal renal neoplasm (HP:0011794)1.88019238
98Hypoplastic labia majora (HP:0000059)1.87054013
99Neoplasm of the adrenal cortex (HP:0100641)1.85941534
100Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.84390550
101Stenosis of the external auditory canal (HP:0000402)1.83672570
102Abnormality of the carotid arteries (HP:0005344)1.81346422
10311 pairs of ribs (HP:0000878)1.81185488
104Microglossia (HP:0000171)1.80196185
105Triphalangeal thumb (HP:0001199)1.80000151
106Curly hair (HP:0002212)1.78793781
107Abnormal lung lobation (HP:0002101)1.78606784
108Sandal gap (HP:0001852)1.77965016
109Aplasia/Hypoplasia of the sternum (HP:0006714)1.76855012
110Premature graying of hair (HP:0002216)1.76068252
111Squamous cell carcinoma (HP:0002860)1.75279060
112Anal stenosis (HP:0002025)1.75253989
113Ankle contracture (HP:0006466)1.74262861
114Abnormality of abdominal situs (HP:0011620)1.74227270
115Abdominal situs inversus (HP:0003363)1.74227270
116Neoplasm of the colon (HP:0100273)1.73760847
117Horseshoe kidney (HP:0000085)1.73642181
118Breast aplasia (HP:0100783)1.73024862
119Abnormality of B cell number (HP:0010975)1.72567771
120Esophageal atresia (HP:0002032)1.72060863
121Capillary hemangiomas (HP:0005306)1.71781495
122Midline defect of the nose (HP:0004122)1.71747294
123Abnormal foot bone ossification (HP:0010675)1.71433007
124Hypoplastic pelvis (HP:0008839)1.70817644
125Facial cleft (HP:0002006)1.70737737
126Short hallux (HP:0010109)1.70136103
127Duplicated collecting system (HP:0000081)1.69883659
128Single umbilical artery (HP:0001195)1.69788952
129Abnormality of the fetal cardiovascular system (HP:0010948)1.69788952
130Abnormal umbilical cord blood vessels (HP:0011403)1.69788952
131Abnormality of the labia majora (HP:0012881)1.69427774
132Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68772981
133Abnormal vertebral ossification (HP:0100569)1.68228154
134Partial duplication of thumb phalanx (HP:0009944)1.67895322
135Ectopic anus (HP:0004397)1.67884971
136Absent frontal sinuses (HP:0002688)1.67829721
137Broad thumb (HP:0011304)1.67287684
138Short 1st metacarpal (HP:0010034)1.67214214
139Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67214214
140Fused cervical vertebrae (HP:0002949)1.66275072
141Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65488959
142Acute lymphatic leukemia (HP:0006721)1.65170577
143Increased nuchal translucency (HP:0010880)1.65125232
144Abnormality of DNA repair (HP:0003254)1.65044721
145Clitoromegaly (HP:0000057)1.65037046
146Aplasia/Hypoplasia of the scapulae (HP:0006713)1.64523661
147Hypoplastic scapulae (HP:0000882)1.64523661
148Choanal atresia (HP:0000453)1.64158553
149Thyroid carcinoma (HP:0002890)1.63101113
150Ovarian neoplasm (HP:0100615)1.60573006
151Transitional cell carcinoma of the bladder (HP:0006740)1.60470537
152Spinal cord lesions (HP:0100561)1.60091032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.80333816
2CDC73.79265998
3CDK123.57414275
4LATS12.70115077
5BUB12.66386492
6NEK22.63396871
7TTK2.52733467
8SRPK12.50597637
9TAF12.34773773
10BRSK22.27413225
11STK38L2.26421495
12ACVR1B2.09370140
13EPHA22.07092047
14PLK11.94306748
15PLK41.89729567
16CDK71.84272373
17MKNK11.79330503
18STK31.78317533
19RPS6KB21.78091958
20EIF2AK11.77583958
21LATS21.74403498
22NEK11.71168751
23PLK31.69095712
24CHEK21.68867421
25NLK1.68168942
26ZAK1.67508465
27MKNK21.65894363
28TLK11.64772403
29WNK31.63887564
30ATR1.62422796
31TNIK1.61571168
32AURKB1.57915146
33BRD41.54923171
34STK41.52445622
35TSSK61.50533105
36STK101.45924170
37PIM11.41659200
38CDK41.40229617
39BMPR1B1.36384619
40RPS6KA41.36372785
41TEC1.35541111
42CHEK11.34826594
43DYRK31.30318101
44EIF2AK31.29833780
45MAP3K81.28264605
46TRIM281.26221694
47VRK11.23164661
48FLT31.21533046
49ATM1.20513766
50MELK1.16534399
51VRK21.12142302
52EEF2K1.05403053
53PIK3CG1.04674434
54CDK60.97418098
55STK390.93973861
56YES10.93918449
57* CDK20.93593001
58NME20.92939532
59TGFBR10.91992332
60PASK0.87859961
61ALK0.87836112
62CAMK1G0.86059166
63CDK90.82304436
64TGFBR20.81405258
65TIE10.81322418
66CHUK0.81220899
67DMPK0.81064131
68AURKA0.79194686
69PBK0.79168746
70PAK40.78323797
71ERBB30.77850551
72AKT30.75895285
73FGFR20.74701149
74BRSK10.74172221
75CDK80.73324881
76MTOR0.73053698
77JAK30.72999006
78ERBB40.72950581
79CDK10.69096568
80PNCK0.68680063
81EIF2AK20.67563000
82MAP3K100.66865390
83RPS6KA50.66147368
84NUAK10.65245003
85SCYL20.62604464
86MARK30.61854411
87IKBKB0.61111370
88PKN20.60980946
89CSNK2A20.54396971
90TAOK30.53239755
91STK240.52861766
92TESK20.52381055
93CSNK1D0.51614504
94FER0.49024882
95CSNK2A10.47968275
96NEK90.47798349
97MET0.47457805
98MST40.46745924
99PRKCI0.44819874
100BMX0.41458726
101MAPK140.40671111
102PAK10.40532005
103EGFR0.40348279
104MAP3K30.40184339
105MAP3K140.39916260
106IRAK10.39789049
107FRK0.38595613
108TRPM70.37940054
109MAPK10.37439611
110FGR0.36679596
111FGFR30.36127299
112PDGFRB0.35993849
113AKT10.35260923
114PRKDC0.34880624
115OXSR10.34361397
116PAK20.33131688
117CSNK1E0.32971794
118NEK60.32074543
119MAP2K30.31614074
120AKT20.30878598
121CLK10.30336986
122LRRK20.29919494
123PLK20.29709883
124BTK0.29322894
125RPS6KB10.28386305
126IGF1R0.28084252
127CDK30.27838664
128RAF10.27774783
129WNK10.27550966
130CAMK1D0.26569421
131FGFR10.24326741
132TYK20.24187230

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.85651882
2Mismatch repair_Homo sapiens_hsa034303.84224375
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77504231
4RNA transport_Homo sapiens_hsa030133.06779326
5Cell cycle_Homo sapiens_hsa041102.96728825
6Homologous recombination_Homo sapiens_hsa034402.89448469
7Spliceosome_Homo sapiens_hsa030402.75755426
8RNA polymerase_Homo sapiens_hsa030202.74799379
9One carbon pool by folate_Homo sapiens_hsa006702.58010897
10Nucleotide excision repair_Homo sapiens_hsa034202.53405354
11Fanconi anemia pathway_Homo sapiens_hsa034602.48208579
12Base excision repair_Homo sapiens_hsa034102.42159840
13Basal transcription factors_Homo sapiens_hsa030222.28159968
14Non-homologous end-joining_Homo sapiens_hsa034502.19417297
15RNA degradation_Homo sapiens_hsa030182.04861524
16p53 signaling pathway_Homo sapiens_hsa041152.00770311
17mRNA surveillance pathway_Homo sapiens_hsa030151.86146251
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84629597
19Ribosome_Homo sapiens_hsa030101.78016863
20Pyrimidine metabolism_Homo sapiens_hsa002401.75609733
21Systemic lupus erythematosus_Homo sapiens_hsa053221.71962439
22Proteasome_Homo sapiens_hsa030501.46045920
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38627735
24Herpes simplex infection_Homo sapiens_hsa051681.35854087
25Viral carcinogenesis_Homo sapiens_hsa052031.33336496
26MicroRNAs in cancer_Homo sapiens_hsa052061.32055719
27Epstein-Barr virus infection_Homo sapiens_hsa051691.24160957
28TGF-beta signaling pathway_Homo sapiens_hsa043501.19855708
29Propanoate metabolism_Homo sapiens_hsa006401.18935391
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15411672
31Antigen processing and presentation_Homo sapiens_hsa046121.14759467
32Small cell lung cancer_Homo sapiens_hsa052221.07439389
33* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.05698733
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02696589
35Steroid biosynthesis_Homo sapiens_hsa001000.97442538
36NF-kappa B signaling pathway_Homo sapiens_hsa040640.95338823
37HTLV-I infection_Homo sapiens_hsa051660.93638199
38Adherens junction_Homo sapiens_hsa045200.92574399
39Protein export_Homo sapiens_hsa030600.90193229
40Thyroid cancer_Homo sapiens_hsa052160.88805764
41Hippo signaling pathway_Homo sapiens_hsa043900.87545259
42Purine metabolism_Homo sapiens_hsa002300.86388292
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85053630
44Oocyte meiosis_Homo sapiens_hsa041140.81738015
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81280650
46Selenocompound metabolism_Homo sapiens_hsa004500.80194195
47NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76351446
48Basal cell carcinoma_Homo sapiens_hsa052170.75819161
49Notch signaling pathway_Homo sapiens_hsa043300.74781463
50Endometrial cancer_Homo sapiens_hsa052130.74624540
51Legionellosis_Homo sapiens_hsa051340.72156837
52Apoptosis_Homo sapiens_hsa042100.68470408
53Measles_Homo sapiens_hsa051620.67955804
54Influenza A_Homo sapiens_hsa051640.65900876
55Pentose phosphate pathway_Homo sapiens_hsa000300.65139303
56Viral myocarditis_Homo sapiens_hsa054160.64368390
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63387249
58Colorectal cancer_Homo sapiens_hsa052100.62995873
59Hepatitis B_Homo sapiens_hsa051610.61471470
60Prostate cancer_Homo sapiens_hsa052150.61283854
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58594317
62Pathways in cancer_Homo sapiens_hsa052000.57896582
63Chronic myeloid leukemia_Homo sapiens_hsa052200.57274616
64Dorso-ventral axis formation_Homo sapiens_hsa043200.55452565
65Lysine degradation_Homo sapiens_hsa003100.52918192
66Biosynthesis of amino acids_Homo sapiens_hsa012300.51438927
67Vitamin B6 metabolism_Homo sapiens_hsa007500.50095229
68Leishmaniasis_Homo sapiens_hsa051400.49560820
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49259959
70mTOR signaling pathway_Homo sapiens_hsa041500.49051140
71Non-small cell lung cancer_Homo sapiens_hsa052230.48385668
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47594423
73Hedgehog signaling pathway_Homo sapiens_hsa043400.46407266
74Platelet activation_Homo sapiens_hsa046110.46391612
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46342657
76Primary immunodeficiency_Homo sapiens_hsa053400.46203712
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.46024182
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.45444032
79Allograft rejection_Homo sapiens_hsa053300.44803131
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.44450213
81Shigellosis_Homo sapiens_hsa051310.44254677
82Alcoholism_Homo sapiens_hsa050340.43770297
83Pancreatic cancer_Homo sapiens_hsa052120.43130674
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42361848
85Proteoglycans in cancer_Homo sapiens_hsa052050.41798760
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.41345381
87HIF-1 signaling pathway_Homo sapiens_hsa040660.41194421
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41163320
89Focal adhesion_Homo sapiens_hsa045100.40830942
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40449342
91Folate biosynthesis_Homo sapiens_hsa007900.40371322
92FoxO signaling pathway_Homo sapiens_hsa040680.40092225
93Graft-versus-host disease_Homo sapiens_hsa053320.39397758
94Hematopoietic cell lineage_Homo sapiens_hsa046400.39199759
95Inositol phosphate metabolism_Homo sapiens_hsa005620.39148604
96TNF signaling pathway_Homo sapiens_hsa046680.38268290
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37668440
98Acute myeloid leukemia_Homo sapiens_hsa052210.37415349
99Bladder cancer_Homo sapiens_hsa052190.37113355
100Toxoplasmosis_Homo sapiens_hsa051450.36130900
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.35887423
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35880408
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.35649819
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35239555
105Tight junction_Homo sapiens_hsa045300.34112110
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33727727
107Regulation of autophagy_Homo sapiens_hsa041400.33247071
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.33190112
109Melanoma_Homo sapiens_hsa052180.33081571
110Amoebiasis_Homo sapiens_hsa051460.32766631
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32467016
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.30854184
113ECM-receptor interaction_Homo sapiens_hsa045120.30190929
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29065095
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.28548205
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26822506
117Glutathione metabolism_Homo sapiens_hsa004800.26253066
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26168091
119Wnt signaling pathway_Homo sapiens_hsa043100.25856692
120Renal cell carcinoma_Homo sapiens_hsa052110.25370247
121Malaria_Homo sapiens_hsa051440.25254390

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