RET

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of transcription regulatory region DNA binding (GO:2000679)8.60414333
2* enteric nervous system development (GO:0048484)8.20439309
3retinoic acid metabolic process (GO:0042573)8.03016791
4dopamine biosynthetic process (GO:0042416)7.75411481
5norepinephrine metabolic process (GO:0042415)7.63446850
6cell migration involved in heart development (GO:0060973)7.10277384
7regulation of skeletal muscle cell differentiation (GO:2001014)7.08504308
8positive regulation of skeletal muscle tissue development (GO:0048643)6.97907243
9dopaminergic neuron differentiation (GO:0071542)6.79154704
10retinoic acid receptor signaling pathway (GO:0048384)6.52349705
11alkaloid metabolic process (GO:0009820)6.46443688
12positive regulation of myotube differentiation (GO:0010831)6.25971315
13cartilage morphogenesis (GO:0060536)6.05245460
14dopamine transport (GO:0015872)6.04511882
15behavioral response to ethanol (GO:0048149)6.02049435
16establishment of skin barrier (GO:0061436)5.74316824
17cardiac ventricle formation (GO:0003211)5.65181637
18neurofilament cytoskeleton organization (GO:0060052)5.43249285
19mating behavior (GO:0007617)5.31237776
20regulation of heart morphogenesis (GO:2000826)5.22947969
21cardiac chamber formation (GO:0003207)5.20505859
22regulation of water loss via skin (GO:0033561)5.12326181
23catecholamine transport (GO:0051937)5.09210205
24proximal/distal pattern formation (GO:0009954)4.97968901
25neurotransmitter biosynthetic process (GO:0042136)4.95866872
26catecholamine biosynthetic process (GO:0042423)4.95553269
27catechol-containing compound biosynthetic process (GO:0009713)4.95553269
28endocardial cushion morphogenesis (GO:0003203)4.88855897
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.77898638
30regulation of respiratory gaseous exchange (GO:0043576)4.77737789
31tongue development (GO:0043586)4.73650746
32negative regulation of striated muscle cell apoptotic process (GO:0010664)4.66581975
33response to insecticide (GO:0017085)4.54091070
34negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.49062636
35synaptic vesicle maturation (GO:0016188)4.40104648
36regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39129160
37mesenchyme morphogenesis (GO:0072132)4.35066821
38phenol-containing compound catabolic process (GO:0019336)4.33452443
39cell migration in hindbrain (GO:0021535)4.31771932
40cellular response to nicotine (GO:0071316)4.31149647
41toxin metabolic process (GO:0009404)4.28278257
42glutamate secretion (GO:0014047)4.28127544
43proline transport (GO:0015824)4.17670389
44synaptic vesicle exocytosis (GO:0016079)4.17222126
45negative regulation of microtubule polymerization (GO:0031115)4.15303397
46negative regulation of neurotransmitter transport (GO:0051589)4.08641547
47peripheral nervous system neuron development (GO:0048935)4.08359154
48maternal behavior (GO:0042711)4.03986297
49ear development (GO:0043583)4.02030626
50embryonic forelimb morphogenesis (GO:0035115)4.01941587
51positive regulation of cell cycle G2/M phase transition (GO:1902751)3.90193226
52positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)3.90193226
53regulation of synaptic vesicle exocytosis (GO:2000300)3.84708737
54male meiosis (GO:0007140)3.84362089
55regulation of retinoic acid receptor signaling pathway (GO:0048385)3.77857669
56regulation of dopamine metabolic process (GO:0042053)3.77850446
57regulation of catecholamine metabolic process (GO:0042069)3.77850446
58neurotransmitter metabolic process (GO:0042133)3.77576217
59prepulse inhibition (GO:0060134)3.74414666
60dopamine metabolic process (GO:0042417)3.70750582
61ectodermal placode formation (GO:0060788)3.70164142
62cranial nerve morphogenesis (GO:0021602)3.69727066
63negative regulation of calcium ion transport into cytosol (GO:0010523)3.68296454
64mesenchymal cell proliferation (GO:0010463)3.66419194
65negative regulation of dendrite morphogenesis (GO:0050774)3.65487426
66ganglion development (GO:0061548)3.64997915
67bone morphogenesis (GO:0060349)3.64173785
68suckling behavior (GO:0001967)3.63795051
69axon cargo transport (GO:0008088)3.59071143
70neuronal action potential (GO:0019228)3.58184587
71neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.57602589
72positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56444392
73neurotransmitter catabolic process (GO:0042135)3.55650405
74parental behavior (GO:0060746)3.55024675
75regulation of cardiac muscle cell apoptotic process (GO:0010665)3.52216781
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.51595308
77response to corticosterone (GO:0051412)3.50659150
78membrane depolarization during action potential (GO:0086010)3.50235218
79synaptic transmission, dopaminergic (GO:0001963)3.49642195
80neurotransmitter secretion (GO:0007269)3.48188404
81adult heart development (GO:0007512)3.46776146
82cell differentiation in hindbrain (GO:0021533)3.46428180
83response to water (GO:0009415)3.45921054
84detection of temperature stimulus (GO:0016048)3.45647117
85regulation of dopamine secretion (GO:0014059)3.45181249
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.44868643
87regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.44834573
88forelimb morphogenesis (GO:0035136)3.44828008
89eyelid development in camera-type eye (GO:0061029)3.44766325
90negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.44444878
91insulin secretion (GO:0030073)3.44190506
92activation of protein kinase A activity (GO:0034199)3.38810515
93regulation of neurotransmitter levels (GO:0001505)3.36275716
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34363273
95apoptotic process involved in development (GO:1902742)3.32836018
96cerebellar Purkinje cell layer development (GO:0021680)3.30432313
97membrane repolarization (GO:0086009)3.29633268
98regulation of striated muscle cell apoptotic process (GO:0010662)3.27667411
99neuromuscular synaptic transmission (GO:0007274)3.26666981
100neuronal action potential propagation (GO:0019227)3.26381233
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.26300919
102regulation of synaptic vesicle transport (GO:1902803)3.25946487
103negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.24589962
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22915028
105detection of temperature stimulus involved in sensory perception (GO:0050961)3.22405510
106detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.22405510
107synaptic transmission, cholinergic (GO:0007271)3.18287157
108negative regulation of DNA repair (GO:0045738)3.17790258
109embryonic camera-type eye morphogenesis (GO:0048596)3.17367413
110auditory behavior (GO:0031223)3.15984342
111monoamine transport (GO:0015844)3.15348396
112body morphogenesis (GO:0010171)3.15147588
113apoptotic process involved in morphogenesis (GO:0060561)3.14459311
114neurotransmitter transport (GO:0006836)3.13138207
115embryonic limb morphogenesis (GO:0030326)3.12812596
116embryonic appendage morphogenesis (GO:0035113)3.12812596
117regulation of fatty acid beta-oxidation (GO:0031998)3.08845400
118urinary tract smooth muscle contraction (GO:0014848)3.08771667
119positive regulation of potassium ion transmembrane transport (GO:1901381)3.05820641
120outflow tract septum morphogenesis (GO:0003148)3.05330387
121cell fate determination (GO:0001709)3.05192643
122phenol-containing compound biosynthetic process (GO:0046189)3.04095983
123* response to pain (GO:0048265)3.03625362
124regulation of mammary gland epithelial cell proliferation (GO:0033599)3.01490765
125neuromuscular process controlling posture (GO:0050884)3.01071636
126neural crest cell development (GO:0014032)3.00625568
127sympathetic nervous system development (GO:0048485)3.00115618
128multicellular organismal water homeostasis (GO:0050891)2.98586308
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.96336770
130embryonic eye morphogenesis (GO:0048048)2.95784271
131cell communication involved in cardiac conduction (GO:0086065)2.95313033
132* neural crest cell migration (GO:0001755)2.95236578
133establishment of synaptic vesicle localization (GO:0097480)2.95230069
134synaptic vesicle transport (GO:0048489)2.95230069
135negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.95059810
136regulation of transcription regulatory region DNA binding (GO:2000677)2.94407576
137response to mineralocorticoid (GO:0051385)2.94064402
138calcium-mediated signaling using intracellular calcium source (GO:0035584)2.92334314
139regulation of cardioblast proliferation (GO:0003264)2.89971703
140regulation of secondary heart field cardioblast proliferation (GO:0003266)2.89971703
141vesicle transport along microtubule (GO:0047496)2.89858620
142response to cocaine (GO:0042220)2.88636066
143neuron projection extension involved in neuron projection guidance (GO:1902284)2.87974078
144axon extension involved in axon guidance (GO:0048846)2.87974078
145regulation of vesicle fusion (GO:0031338)2.86606899
146cell communication by electrical coupling (GO:0010644)2.83685353
147protein maturation by protein folding (GO:0022417)2.82989579
148cellular potassium ion homeostasis (GO:0030007)2.81725741
149sodium ion export (GO:0071436)2.81601080
150cerebellar Purkinje cell differentiation (GO:0021702)2.81403718
151adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.80482935
152membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.80421044
153embryonic body morphogenesis (GO:0010172)2.79587152
154fat-soluble vitamin metabolic process (GO:0006775)2.78488103
155organelle transport along microtubule (GO:0072384)2.77211161
156positive regulation of potassium ion transport (GO:0043268)2.77149913
157central nervous system neuron axonogenesis (GO:0021955)2.74250232
158behavioral response to pain (GO:0048266)2.74016234
159multicellular organismal aging (GO:0010259)2.73737911
160locomotory exploration behavior (GO:0035641)2.73388995
161semaphorin-plexin signaling pathway (GO:0071526)2.72228396
162regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.70897157
163establishment of vesicle localization (GO:0051650)2.67467780
164regulation of respiratory system process (GO:0044065)2.66973889
165regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66472974
166coronary vasculature morphogenesis (GO:0060977)2.66185458
167limb morphogenesis (GO:0035108)2.65982716
168appendage morphogenesis (GO:0035107)2.65982716
169negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64854661
170peptide hormone secretion (GO:0030072)2.64772002
171short-term memory (GO:0007614)2.63559800
172cellular response to glucagon stimulus (GO:0071377)2.63276688
173exploration behavior (GO:0035640)2.62307468
174mesenchymal cell development (GO:0014031)2.60815675
175layer formation in cerebral cortex (GO:0021819)2.60488572
176behavioral response to nicotine (GO:0035095)2.59375005
177regulation of neurotransmitter transport (GO:0051588)2.59183768
178positive regulation of exocytosis (GO:0045921)2.58081880
179vitamin catabolic process (GO:0009111)11.5877367
180fat-soluble vitamin catabolic process (GO:0042363)11.5877367

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.54018747
2ESR1_15608294_ChIP-ChIP_MCF-7_Human4.45681894
3E2F7_22180533_ChIP-Seq_HELA_Human3.60422745
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99061374
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.88267811
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81652955
7* ESR1_21235772_ChIP-Seq_MCF-7_Human2.79534351
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75842916
9IGF1R_20145208_ChIP-Seq_DFB_Human2.63819034
10REST_21632747_ChIP-Seq_MESCs_Mouse2.63804392
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62476961
12* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57740329
13* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57740329
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57543498
15* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56011013
16* NR3C1_23031785_ChIP-Seq_PC12_Mouse2.52109822
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49301197
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47924740
19GBX2_23144817_ChIP-Seq_PC3_Human2.39741294
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.37809404
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37315562
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.33805083
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.32150446
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29630806
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27564182
26TAF15_26573619_Chip-Seq_HEK293_Human2.20527837
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18494245
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.16976933
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.10934192
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10624758
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.99845030
32* DROSHA_22980978_ChIP-Seq_HELA_Human1.95114082
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94008588
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.92382039
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.90887045
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90860263
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.90023074
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.89445577
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.87221370
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.79502930
41* RACK7_27058665_Chip-Seq_MCF-7_Human1.75441681
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70805807
43RARB_27405468_Chip-Seq_BRAIN_Mouse1.67164627
44LXR_22292898_ChIP-Seq_THP-1_Human1.65948087
45ZFP281_27345836_Chip-Seq_ESCs_Mouse1.65472252
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.65330814
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61803926
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57222214
49SMAD4_21799915_ChIP-Seq_A2780_Human1.54114824
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53914890
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53241277
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50698736
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49518242
54KDM2B_26808549_Chip-Seq_K562_Human1.49277083
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.44919510
56* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42543855
57OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.41889995
58ZNF263_19887448_ChIP-Seq_K562_Human1.41300102
59MYC_22102868_ChIP-Seq_BL_Human1.40028785
60SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39916371
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35238952
62* RUNX1_27514584_Chip-Seq_MCF-7_Human1.34407339
63STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.33978526
64BCAT_22108803_ChIP-Seq_LS180_Human1.33778946
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.32438669
66KDM2B_26808549_Chip-Seq_DND41_Human1.32291909
67TCF7_22412390_ChIP-Seq_EML_Mouse1.32149012
68MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32084147
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31632821
70* ZNF274_21170338_ChIP-Seq_K562_Hela1.30619410
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28544115
72* CTCF_27219007_Chip-Seq_Bcells_Human1.27336579
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.25991109
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25946747
75PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25062123
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.22717881
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20813108
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19384416
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18415396
80STAT3_23295773_ChIP-Seq_U87_Human1.15952565
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15651588
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.15362775
83CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15316886
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15262860
85* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15003502
86TET1_21490601_ChIP-Seq_MESCs_Mouse1.14449425
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.12440466
88TET1_21451524_ChIP-Seq_MESCs_Mouse1.12037558
89RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11383358
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09995744
91WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09755741
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.08667623
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08429437
94NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08387190
95POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08134807
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07892098
97OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07577922
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06550432
99ISL1_27105846_Chip-Seq_CPCs_Mouse1.06444476
100VDR_22108803_ChIP-Seq_LS180_Human1.05818379
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05677590
102AHR_22903824_ChIP-Seq_MCF-7_Human1.04597231
103* VDR_21846776_ChIP-Seq_THP-1_Human1.04056164
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.03537516
105SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02069463
106P300_19829295_ChIP-Seq_ESCs_Human1.01811324
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00691334
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00658413
109SMC4_20622854_ChIP-Seq_HELA_Human1.00462671
110MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97900109
111* AR_19668381_ChIP-Seq_PC3_Human0.97746029
112* SA1_27219007_Chip-Seq_ERYTHROID_Human0.97350809
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96545108
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95819543
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95335067
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.94616513
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94252755
118SMAD4_21741376_ChIP-Seq_HESCs_Human0.93760043
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92683440
120DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91554867
121AR_25329375_ChIP-Seq_VCAP_Human0.91104703
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90522733
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90428311
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90061510
125* ESR2_21235772_ChIP-Seq_MCF-7_Human0.89384029
126POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.89348357
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89177253
128KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88812607
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88567064
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88058408
131RNF2_27304074_Chip-Seq_NSC_Mouse0.87959131
132* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87359734
133ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87337380
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.86867083
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85734261
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84842573
137EP300_21415370_ChIP-Seq_HL-1_Mouse0.83248597
138SMAD3_21741376_ChIP-Seq_EPCs_Human0.82868833
139TCF4_23295773_ChIP-Seq_U87_Human0.82229737
140* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81168362
141SMAD4_21741376_ChIP-Seq_EPCs_Human0.81051030
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80790823
143* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80237233
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78727514
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.77549647
146RUNX2_22187159_ChIP-Seq_PCA_Human0.77522862

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia6.87564411
2MP0002735_abnormal_chemical_nociception4.73897941
3MP0001968_abnormal_touch/_nociception4.22063947
4MP0006276_abnormal_autonomic_nervous4.14586490
5MP0004858_abnormal_nervous_system3.92864058
6MP0002736_abnormal_nociception_after3.80427675
7MP0002733_abnormal_thermal_nociception3.48452418
8MP0002909_abnormal_adrenal_gland3.12347445
9MP0004270_analgesia3.05556504
10MP0002734_abnormal_mechanical_nocicepti3.04403897
11MP0003880_abnormal_central_pattern3.01850917
12MP0001905_abnormal_dopamine_level2.84266498
13MP0001970_abnormal_pain_threshold2.79313590
14MP0004859_abnormal_synaptic_plasticity2.67626222
15MP0003122_maternal_imprinting2.56162336
16MP0003567_abnormal_fetal_cardiomyocyte2.48155185
17* MP0003635_abnormal_synaptic_transmissio2.39543573
18MP0001986_abnormal_taste_sensitivity2.34574202
19MP0001529_abnormal_vocalization2.29537803
20MP0005423_abnormal_somatic_nervous2.10035252
21MP0002272_abnormal_nervous_system2.08570315
22MP0009046_muscle_twitch2.02853956
23* MP0002184_abnormal_innervation1.91377008
24MP0001501_abnormal_sleep_pattern1.88126386
25* MP0002751_abnormal_autonomic_nervous1.83093316
26MP0002822_catalepsy1.82153137
27MP0009745_abnormal_behavioral_response1.81996745
28MP0002064_seizures1.81018278
29MP0005645_abnormal_hypothalamus_physiol1.80885441
30MP0002067_abnormal_sensory_capabilities1.79815307
31MP0003183_abnormal_peptide_metabolism1.78503908
32MP0002166_altered_tumor_susceptibility1.76290410
33MP0002572_abnormal_emotion/affect_behav1.68514398
34MP0002063_abnormal_learning/memory/cond1.67957836
35MP0004264_abnormal_extraembryonic_tissu1.63284471
36* MP0000955_abnormal_spinal_cord1.62852412
37MP0001440_abnormal_grooming_behavior1.61226633
38MP0003283_abnormal_digestive_organ1.60766062
39* MP0000538_abnormal_urinary_bladder1.60743641
40MP0005503_abnormal_tendon_morphology1.60214416
41MP0009780_abnormal_chondrocyte_physiolo1.58974967
42MP0004924_abnormal_behavior1.51402275
43MP0005386_behavior/neurological_phenoty1.51402275
44* MP0004811_abnormal_neuron_physiology1.50998281
45MP0005409_darkened_coat_color1.50645434
46MP0003705_abnormal_hypodermis_morpholog1.48649173
47MP0000428_abnormal_craniofacial_morphol1.48506412
48MP0003329_amyloid_beta_deposits1.48102229
49MP0008961_abnormal_basal_metabolism1.46470958
50MP0002837_dystrophic_cardiac_calcinosis1.43543263
51* MP0000534_abnormal_ureter_morphology1.43124404
52MP0001340_abnormal_eyelid_morphology1.40601041
53MP0000013_abnormal_adipose_tissue1.39245530
54MP0003045_fibrosis1.38870906
55MP0008872_abnormal_physiological_respon1.36900850
56MP0001348_abnormal_lacrimal_gland1.36528662
57MP0005367_renal/urinary_system_phenotyp1.34041968
58MP0000516_abnormal_urinary_system1.34041968
59MP0002638_abnormal_pupillary_reflex1.33222992
60MP0010386_abnormal_urinary_bladder1.30279091
61MP0002557_abnormal_social/conspecific_i1.29452713
62MP0001299_abnormal_eye_distance/1.25513144
63MP0001502_abnormal_circadian_rhythm1.23769105
64MP0002653_abnormal_ependyma_morphology1.22979043
65MP0000778_abnormal_nervous_system1.22291883
66MP0005083_abnormal_biliary_tract1.21144218
67MP0005535_abnormal_body_temperature1.18661911
68MP0000569_abnormal_digit_pigmentation1.16985173
69* MP0003942_abnormal_urinary_system1.16501857
70* MP0002882_abnormal_neuron_morphology1.14980355
71MP0002127_abnormal_cardiovascular_syste1.13723804
72MP0006072_abnormal_retinal_apoptosis1.12334166
73MP0000462_abnormal_digestive_system1.10839655
74MP0004043_abnormal_pH_regulation1.10454973
75MP0001486_abnormal_startle_reflex1.09710341
76MP0000747_muscle_weakness1.09312582
77MP0006138_congestive_heart_failure1.07162461
78MP0002139_abnormal_hepatobiliary_system1.06816054
79MP0002006_tumorigenesis1.06472116
80* MP0002066_abnormal_motor_capabilities/c1.04699745
81MP0004233_abnormal_muscle_weight1.03951608
82MP0000751_myopathy1.03738231
83MP0004145_abnormal_muscle_electrophysio1.03032087
84MP0008569_lethality_at_weaning1.02857130
85* MP0001664_abnormal_digestion1.01803336
86MP0005379_endocrine/exocrine_gland_phen1.01803005
87MP0005076_abnormal_cell_differentiation1.00486240
88MP0005187_abnormal_penis_morphology1.00308471
89MP0003937_abnormal_limbs/digits/tail_de0.96269902
90MP0002229_neurodegeneration0.95732493
91MP0002693_abnormal_pancreas_physiology0.95231972
92MP0000372_irregular_coat_pigmentation0.95055955
93MP0001188_hyperpigmentation0.88392084
94MP0001944_abnormal_pancreas_morphology0.86397617
95MP0002084_abnormal_developmental_patter0.85041109
96MP0003123_paternal_imprinting0.84831013
97MP0005171_absent_coat_pigmentation0.84426053
98MP0003634_abnormal_glial_cell0.83433847
99MP0002249_abnormal_larynx_morphology0.83347049
100MP0004883_abnormal_blood_vessel0.82881796
101MP0005197_abnormal_uvea_morphology0.81735872
102MP0003631_nervous_system_phenotype0.80417364
103MP0003633_abnormal_nervous_system0.78931091
104MP0002069_abnormal_eating/drinking_beha0.78895597
105MP0004036_abnormal_muscle_relaxation0.78404891
106* MP0003861_abnormal_nervous_system0.78016218
107MP0009672_abnormal_birth_weight0.77913909
108MP0003011_delayed_dark_adaptation0.77486728
109MP0003959_abnormal_lean_body0.76556021
110MP0002116_abnormal_craniofacial_bone0.76150458
111MP0010307_abnormal_tumor_latency0.75999428
112MP0000049_abnormal_middle_ear0.75860637
113MP0003646_muscle_fatigue0.75840322
114MP0004142_abnormal_muscle_tone0.75836999
115MP0003632_abnormal_nervous_system0.75219860
116MP0010030_abnormal_orbit_morphology0.74989535
117MP0004084_abnormal_cardiac_muscle0.73830580
118MP0004742_abnormal_vestibular_system0.73381633
119MP0001984_abnormal_olfaction0.71953331
120* MP0002109_abnormal_limb_morphology0.71256704
121MP0002697_abnormal_eye_size0.70020719
122MP0004085_abnormal_heartbeat0.69289461
123MP0008874_decreased_physiological_sensi0.69034519
124* MP0002752_abnormal_somatic_nervous0.68594359
125MP0002078_abnormal_glucose_homeostasis0.67621090
126MP0001730_embryonic_growth_arrest0.67175126
127MP0000003_abnormal_adipose_tissue0.66310204
128MP0010094_abnormal_chromosome_stability0.65743254
129MP0001177_atelectasis0.65525495
130* MP0002085_abnormal_embryonic_tissue0.64128176
131MP0005646_abnormal_pituitary_gland0.63768297
132MP0003077_abnormal_cell_cycle0.62919041
133MP0001756_abnormal_urination0.62511370
134MP0003787_abnormal_imprinting0.62300521
135* MP0001270_distended_abdomen0.61778795
136MP0002090_abnormal_vision0.61692514
137MP0001943_abnormal_respiration0.60820976
138* MP0001731_abnormal_postnatal_growth0.60635587
139MP0002332_abnormal_exercise_endurance0.59617163
140MP0002163_abnormal_gland_morphology0.59175097
141MP0003935_abnormal_craniofacial_develop0.58995769
142* MP0002081_perinatal_lethality0.58479077
143MP0002152_abnormal_brain_morphology0.57648623
144MP0000631_abnormal_neuroendocrine_gland0.57575922
145* MP0010770_preweaning_lethality0.55165596
146* MP0002082_postnatal_lethality0.55165596
147MP0000579_abnormal_nail_morphology0.51669472
148* MP0010769_abnormal_survival0.51334764
149MP0003948_abnormal_gas_homeostasis0.51194080
150MP0000427_abnormal_hair_cycle0.51127428
151MP0004130_abnormal_muscle_cell0.50341194
152* MP0010768_mortality/aging0.50021576
153* MP0000759_abnormal_skeletal_muscle0.50016673
154MP0004782_abnormal_surfactant_physiolog0.49715805
155MP0002080_prenatal_lethality0.48960612
156MP0009278_abnormal_bone_marrow0.48432101
157MP0002108_abnormal_muscle_morphology0.47110369
158MP0010630_abnormal_cardiac_muscle0.46170334
159MP0005248_abnormal_Harderian_gland0.44143391
160MP0002098_abnormal_vibrissa_morphology0.43852719

Predicted human phenotypes

RankGene SetZ-score
1Synostosis involving the elbow (HP:0003938)9.62482289
2Humeroradial synostosis (HP:0003041)9.62482289
3Limb dystonia (HP:0002451)9.25606881
4Neonatal hypoglycemia (HP:0001998)8.69047476
5Oligodactyly (HP:0012165)8.32850343
6Occipital encephalocele (HP:0002085)6.91371985
7Ulnar claw (HP:0001178)5.47482835
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.09703590
9Hypothermia (HP:0002045)5.06224846
10Myokymia (HP:0002411)4.89565966
11Visual hallucinations (HP:0002367)4.76255079
12Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.57417421
13Action tremor (HP:0002345)4.49694193
14Agitation (HP:0000713)4.01329714
15Termporal pattern (HP:0011008)3.79986040
16Insidious onset (HP:0003587)3.79986040
17Abnormality of the humeroradial joint (HP:0100744)3.64916628
18Postural tremor (HP:0002174)3.64875162
19Abnormality of the phalanges of the hallux (HP:0010057)3.63799574
20Supranuclear gaze palsy (HP:0000605)3.60542861
21Dysautonomia (HP:0002459)3.50370827
22Asymmetry of the thorax (HP:0001555)3.47778048
23* Hypercortisolism (HP:0001578)3.41200623
24Focal seizures (HP:0007359)3.38791351
25Abnormality of pain sensation (HP:0010832)3.34822401
26Impaired pain sensation (HP:0007328)3.34822401
27Annular pancreas (HP:0001734)3.33702287
28Progressive cerebellar ataxia (HP:0002073)3.32658972
29External ophthalmoplegia (HP:0000544)3.30608088
30Segmental peripheral demyelination/remyelination (HP:0003481)3.25291124
31* Pheochromocytoma (HP:0002666)3.24279261
32Buphthalmos (HP:0000557)3.16309188
33Menstrual irregularities (HP:0000858)3.12422953
34Turricephaly (HP:0000262)3.11010172
35Ankle clonus (HP:0011448)3.06050274
36Hammertoe (HP:0001765)3.05164489
37Amblyopia (HP:0000646)3.02573883
38* Abnormality of calcium-phosphate metabolism (HP:0100530)2.95672902
39Atonic seizures (HP:0010819)2.93245686
40Abnormality of the upper arm (HP:0001454)2.90201508
41Abnormal pupillary function (HP:0007686)2.89097005
42Shawl scrotum (HP:0000049)2.87667549
43Abnormality of the humerus (HP:0003063)2.87206254
44* Neuroendocrine neoplasm (HP:0100634)2.85623057
45Morphological abnormality of the pyramidal tract (HP:0002062)2.77580316
46Depression (HP:0000716)2.76184625
47Midline defect of the nose (HP:0004122)2.71404966
48Hypokinesia (HP:0002375)2.71038459
49Myotonia (HP:0002486)2.66009105
50Mask-like facies (HP:0000298)2.65926784
51Septate vagina (HP:0001153)2.65876473
52Foot dorsiflexor weakness (HP:0009027)2.63076560
53Focal motor seizures (HP:0011153)2.59513858
54Hyperthyroidism (HP:0000836)2.58812860
55Abnormality of the phalanges of the 2nd finger (HP:0009541)2.58627450
56Anxiety (HP:0000739)2.58444161
57Elfin facies (HP:0004428)2.56647802
58Testicular neoplasm (HP:0010788)2.56525336
59* Hypoventilation (HP:0002791)2.55895187
60Cerebral inclusion bodies (HP:0100314)2.55497130
61Truncal ataxia (HP:0002078)2.54340261
62Abnormal pancreas size (HP:0012094)2.54038150
63Ventricular fibrillation (HP:0001663)2.53198388
64Muscular hypotonia of the trunk (HP:0008936)2.51933575
65Abnormality of the corticospinal tract (HP:0002492)2.50882839
66Delayed gross motor development (HP:0002194)2.49100795
67Abnormality of the vocal cords (HP:0008777)2.48500606
68Renovascular hypertension (HP:0100817)2.47899436
69Rigidity (HP:0002063)2.45239574
70Abnormal autonomic nervous system physiology (HP:0012332)2.41961882
71Cortical dysplasia (HP:0002539)2.41242093
72Generalized tonic-clonic seizures (HP:0002069)2.40434129
73Steppage gait (HP:0003376)2.40354538
74Overriding aorta (HP:0002623)2.38863853
75Papilledema (HP:0001085)2.38145471
76Growth hormone excess (HP:0000845)2.37871098
77Short clavicles (HP:0000894)2.37408009
78Partial duplication of the phalanx of hand (HP:0009999)2.35521464
79Abnormality of the parietal bone (HP:0002696)2.34505537
80Enlarged penis (HP:0000040)2.32673455
81Brachycephaly (HP:0000248)2.32339914
82Abnormality of the foot musculature (HP:0001436)2.31784123
83Spinal muscular atrophy (HP:0007269)2.28614705
84Absence seizures (HP:0002121)2.28283761
85Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.28244225
86Long toe (HP:0010511)2.26728792
87Insomnia (HP:0100785)2.26034438
88Bradykinesia (HP:0002067)2.24235588
89Febrile seizures (HP:0002373)2.23245176
90Rapidly progressive (HP:0003678)2.22691089
91Abnormality of the carotid arteries (HP:0005344)2.22622519
92Aplastic anemia (HP:0001915)2.21806248
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21457189
94Exotropia (HP:0000577)2.19579059
95Macroorchidism (HP:0000053)2.15745655
96Congenital glaucoma (HP:0001087)2.15289843
97Chromsome breakage (HP:0040012)2.13439835
98Distal sensory impairment (HP:0002936)2.11531297
99Spastic gait (HP:0002064)2.11511192
100Urinary urgency (HP:0000012)2.11291998
101Abnormality of the aortic arch (HP:0012303)2.09802559
102Diminished movement (HP:0002374)2.06569301
103Restlessness (HP:0000711)2.04733668
104Onion bulb formation (HP:0003383)2.04412321
105Arachnodactyly (HP:0001166)2.04351053
106Thoracolumbar scoliosis (HP:0002944)2.03533529
107Dialeptic seizures (HP:0011146)2.02134920
108Abnormality of the 2nd finger (HP:0004100)2.01252382
109Aplasia/Hypoplasia of the clavicles (HP:0006710)1.99052298
110Hand muscle atrophy (HP:0009130)1.97510244
111Torticollis (HP:0000473)1.95910390
112Renal duplication (HP:0000075)1.95626938
113* Failure to thrive in infancy (HP:0001531)1.95265338
114Orthostatic hypotension (HP:0001278)1.94907136
115Aplasia/Hypoplasia of the brainstem (HP:0007362)1.94739005
116Hypoplasia of the brainstem (HP:0002365)1.94739005
117Flat cornea (HP:0007720)1.92957813
118Poor suck (HP:0002033)1.92006541
119Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91971498
120EEG with generalized epileptiform discharges (HP:0011198)1.91552340
121Delusions (HP:0000746)1.91454586
122Psychosis (HP:0000709)1.91394157
123J-shaped sella turcica (HP:0002680)1.91080705
124Decreased motor nerve conduction velocity (HP:0003431)1.91002415
125Hypotension (HP:0002615)1.90783601
126Ectopic kidney (HP:0000086)1.89869739
127Gait ataxia (HP:0002066)1.88699193
128Abnormality of the lower motor neuron (HP:0002366)1.88032997
129Hypsarrhythmia (HP:0002521)1.87980017
130High anterior hairline (HP:0009890)1.87662334
131Patellar dislocation (HP:0002999)1.85124914
132* Hyperparathyroidism (HP:0000843)1.84781324
133Sacral dimple (HP:0000960)1.84229019
134Hallux valgus (HP:0001822)1.83852189
135Depressed nasal tip (HP:0000437)1.83730253
136Oligomenorrhea (HP:0000876)1.83263433
137Epileptiform EEG discharges (HP:0011182)1.83074167
138Vertebral arch anomaly (HP:0008438)1.82286626
139Breast carcinoma (HP:0003002)1.81147188
140Radioulnar synostosis (HP:0002974)1.79943606
141Patellar aplasia (HP:0006443)1.79923610
142Craniofacial dystonia (HP:0012179)1.78808765
143Striae distensae (HP:0001065)1.78564269
144Bradycardia (HP:0001662)1.78470145
145Clonus (HP:0002169)1.77517333
146Hyperacusis (HP:0010780)1.77490203
147Overlapping toe (HP:0001845)1.74419434
148Lower limb muscle weakness (HP:0007340)1.74286102
149Coronal craniosynostosis (HP:0004440)1.74246821
150Deviation of the hallux (HP:0010051)1.74067834
151Neoplasm of the heart (HP:0100544)1.72614341
152Distal arthrogryposis (HP:0005684)1.72004687
153Bilateral microphthalmos (HP:0007633)1.70669904
154Deformed sella turcica (HP:0002681)1.68155295
155Increased nuchal translucency (HP:0010880)1.68021179
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.64859439
157* Bicornuate uterus (HP:0000813)1.61575398
158Shallow orbits (HP:0000586)1.60906157
159Exostoses (HP:0100777)1.60631567
160Megalocornea (HP:0000485)1.57685430
161Aplasia/hypoplasia of the humerus (HP:0006507)1.57330980
162EMG: neuropathic changes (HP:0003445)1.56901714
163Short humerus (HP:0005792)1.56651671
164Aplasia/Hypoplasia of the patella (HP:0006498)1.54318561
165Spinal cord compression (HP:0002176)1.53855647
166Hyperventilation (HP:0002883)1.51107048
167Abnormality of the 4th metacarpal (HP:0010012)1.49539774
168Anteriorly placed anus (HP:0001545)1.49408585
169Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.48796459
170Short 4th metacarpal (HP:0010044)1.48796459
171Prominent occiput (HP:0000269)1.46818517
172Limb hypertonia (HP:0002509)1.44276294
173Bladder diverticulum (HP:0000015)1.44235603
174Thin bony cortex (HP:0002753)1.42628565
175Bladder neoplasm (HP:0009725)1.42188234
176Bladder carcinoma (HP:0002862)1.42188234
177Cutaneous finger syndactyly (HP:0010554)1.40748725
178Spina bifida occulta (HP:0003298)1.37907099
179Precocious puberty (HP:0000826)1.35205020
180Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.34122364
181* Neuroblastic tumors (HP:0004376)1.34118177
182* Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.34118177
183* Primitive neuroectodermal tumor (HP:0030065)1.34118177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.12275690
2PLK44.43110534
3NTRK14.31540495
4MAP3K93.91561784
5MAPKAPK53.48287968
6AKT33.39059863
7NTRK33.18831678
8GRK53.15085763
9ICK3.12821397
10MINK12.95048610
11EEF2K2.84361427
12KSR22.73658614
13MAP3K22.70772711
14MAP3K122.63335118
15LMTK22.52061776
16CASK2.38133282
17SMG12.36637466
18MAP3K42.15551151
19PNCK2.09074028
20MAP3K102.00362369
21MUSK1.96012689
22LATS21.94686517
23LIMK11.94094226
24ARAF1.91161752
25WNK41.87481400
26CSNK1G31.85510070
27MAP2K41.83150494
28CSNK1G21.82921666
29RPS6KB21.61753265
30SCYL21.57130134
31DDR21.41687060
32FLT31.39356263
33EIF2AK11.38796083
34MAP3K11.38010779
35WNK11.36883688
36PHKG11.32765471
37PHKG21.32765471
38UHMK11.32603937
39MAP2K71.32087638
40MARK11.31214599
41NME21.27861383
42PRKD31.27846650
43PAK61.25673942
44* RET1.23337241
45CSNK1G11.22839288
46FGFR21.22554833
47TYRO31.19464702
48DYRK1B1.19384650
49MTOR1.17229906
50CDK51.15764548
51RPS6KA21.13583885
52STK391.11759770
53CAMKK21.11297602
54TESK21.08579421
55PDGFRA1.08282409
56CDK141.07124250
57HIPK21.07011158
58FER1.04539147
59INSRR1.01852846
60TAF10.99598011
61PLK20.99138405
62TESK10.99010623
63EPHA30.98133246
64CAMK2A0.97823726
65ILK0.95179335
66MAPK130.93768791
67CAMK2D0.91739305
68DYRK30.91351709
69VRK20.90107260
70ADRBK10.89896426
71MAP2K10.88264150
72CDC42BPA0.87588019
73FGFR40.87409230
74CDK150.86922595
75ALK0.86822067
76CDK180.86318328
77SRPK10.86140325
78CAMKK10.85012601
79CAMK1D0.83562543
80PIK3CA0.77650221
81CHEK20.77614108
82CDK11A0.76783247
83PTK2B0.76564800
84CDK70.73771874
85CAMK1G0.73710506
86DYRK20.73597673
87CAMK2G0.73323920
88CDK120.73133986
89PAK30.69816336
90CDC70.68479737
91CHUK0.68432846
92MET0.68235327
93CAMK2B0.66917039
94TTK0.66834852
95PRKCH0.66469187
96DAPK20.66204390
97MAPKAPK30.65871776
98NEK10.64546737
99ATR0.64163557
100RIPK40.64156319
101ADRBK20.63386220
102TSSK60.63169358
103SGK2230.62545535
104SGK4940.62545535
105PRKCG0.61798920
106MKNK20.61124822
107FRK0.61099469
108PRKG20.59897753
109AURKA0.59815208
110GRK60.57872761
111IRAK30.56548987
112MAP2K20.56331810
113MKNK10.55297446
114SGK30.53333933
115MATK0.52826812
116PTK60.50583975
117STK40.47775336
118AKT10.46643233
119NTRK20.45491956
120CDK20.45348816
121PDGFRB0.44779047
122TLK10.43489797
123CAMK10.42804289
124MAPK100.41831436
125MAPK140.41167704
126PRKCE0.41085435
127RIPK10.40638470
128BMPR1B0.40290919
129ERBB20.40280264
130CDK10.39514436
131RPS6KA10.38815188
132PASK0.38401592
133TAOK30.37918586
134RPS6KL10.37748192
135RPS6KC10.37748192
136MAPK150.37564814
137CSNK1E0.37000916
138PRKACG0.36610447
139MAPK80.36419608
140* PTK20.35349382
141DMPK0.35142664
142CSNK1A1L0.35094926
143RPS6KB10.34254621
144TRPM70.33765920
145MELK0.33125327
146PRPF4B0.33115915
147* PRKACA0.32068059
148SIK10.31356820
149ROCK10.31075754
150CSNK1A10.30968530
151FGR0.30643897
152SGK20.30277491
153PKN20.29586848
154PDPK10.28329158
155CAMK40.28156403
156PDK10.28034293
157FGFR30.27474955
158BRAF0.26723504

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.82908187
2Cocaine addiction_Homo sapiens_hsa050303.16928139
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.11480774
4Non-small cell lung cancer_Homo sapiens_hsa052233.11333204
5Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.92395541
6Amphetamine addiction_Homo sapiens_hsa050312.58129394
7Dopaminergic synapse_Homo sapiens_hsa047282.47256034
8Insulin secretion_Homo sapiens_hsa049112.41297126
9Vibrio cholerae infection_Homo sapiens_hsa051102.09799535
10Collecting duct acid secretion_Homo sapiens_hsa049661.95689636
11Parkinsons disease_Homo sapiens_hsa050121.95043104
12Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.94784959
13Cholinergic synapse_Homo sapiens_hsa047251.91173946
14Taste transduction_Homo sapiens_hsa047421.74487909
15Maturity onset diabetes of the young_Homo sapiens_hsa049501.72263470
16Circadian entrainment_Homo sapiens_hsa047131.70566138
17Serotonergic synapse_Homo sapiens_hsa047261.67256702
18Long-term potentiation_Homo sapiens_hsa047201.63061982
19Chronic myeloid leukemia_Homo sapiens_hsa052201.60581001
20Oxidative phosphorylation_Homo sapiens_hsa001901.59480984
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58056601
22Type II diabetes mellitus_Homo sapiens_hsa049301.54854792
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.49264383
24AMPK signaling pathway_Homo sapiens_hsa041521.49219107
25Long-term depression_Homo sapiens_hsa047301.48054135
26Salivary secretion_Homo sapiens_hsa049701.47490026
27Nicotine addiction_Homo sapiens_hsa050331.45261949
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41695183
29GABAergic synapse_Homo sapiens_hsa047271.40312619
30Colorectal cancer_Homo sapiens_hsa052101.37497028
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35357281
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34649938
33Dorso-ventral axis formation_Homo sapiens_hsa043201.34037193
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33496968
35Olfactory transduction_Homo sapiens_hsa047401.32416221
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31970811
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29934002
38Estrogen signaling pathway_Homo sapiens_hsa049151.27987531
39Gap junction_Homo sapiens_hsa045401.27038451
40Alzheimers disease_Homo sapiens_hsa050101.26359266
41Lysine degradation_Homo sapiens_hsa003101.25999486
42Glutamatergic synapse_Homo sapiens_hsa047241.19715767
43Retinol metabolism_Homo sapiens_hsa008301.19687133
44GnRH signaling pathway_Homo sapiens_hsa049121.18662707
45Gastric acid secretion_Homo sapiens_hsa049711.18377166
46Cardiac muscle contraction_Homo sapiens_hsa042601.18244369
47mRNA surveillance pathway_Homo sapiens_hsa030151.17624376
48Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.14876440
49Renin secretion_Homo sapiens_hsa049241.10727549
50Thyroid hormone synthesis_Homo sapiens_hsa049181.08296744
51Morphine addiction_Homo sapiens_hsa050321.07851803
52* Thyroid cancer_Homo sapiens_hsa052161.07453014
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06452796
54MicroRNAs in cancer_Homo sapiens_hsa052061.05365680
55Prolactin signaling pathway_Homo sapiens_hsa049171.05172151
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02863090
57Tyrosine metabolism_Homo sapiens_hsa003501.00934326
58Pancreatic secretion_Homo sapiens_hsa049720.99605976
59Acute myeloid leukemia_Homo sapiens_hsa052210.98530903
60Pancreatic cancer_Homo sapiens_hsa052120.97168607
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96793968
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.96393338
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94333109
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93840187
65Prostate cancer_Homo sapiens_hsa052150.93634001
66Calcium signaling pathway_Homo sapiens_hsa040200.93388708
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92337036
68Renal cell carcinoma_Homo sapiens_hsa052110.91587896
69Insulin signaling pathway_Homo sapiens_hsa049100.90571040
70Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90085934
71DNA replication_Homo sapiens_hsa030300.86671883
72Alcoholism_Homo sapiens_hsa050340.86255305
73Melanogenesis_Homo sapiens_hsa049160.86081856
74Phenylalanine metabolism_Homo sapiens_hsa003600.85158438
75Fanconi anemia pathway_Homo sapiens_hsa034600.84566041
76Glucagon signaling pathway_Homo sapiens_hsa049220.84241031
77Glioma_Homo sapiens_hsa052140.83335627
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.81191510
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80644532
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79315447
81Notch signaling pathway_Homo sapiens_hsa043300.78990165
82Bladder cancer_Homo sapiens_hsa052190.78484112
83Oxytocin signaling pathway_Homo sapiens_hsa049210.78227583
84Spliceosome_Homo sapiens_hsa030400.76595784
85Tight junction_Homo sapiens_hsa045300.76307058
86Huntingtons disease_Homo sapiens_hsa050160.75375960
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74999069
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74087108
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72321242
90Cell cycle_Homo sapiens_hsa041100.70422820
91Oocyte meiosis_Homo sapiens_hsa041140.69922839
92mTOR signaling pathway_Homo sapiens_hsa041500.67359576
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67045328
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.65736956
95ErbB signaling pathway_Homo sapiens_hsa040120.65291364
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64559467
97Protein export_Homo sapiens_hsa030600.63948910
98RNA transport_Homo sapiens_hsa030130.63537371
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62760976
100Phagosome_Homo sapiens_hsa041450.61814007
101Proteoglycans in cancer_Homo sapiens_hsa052050.61685379
102cAMP signaling pathway_Homo sapiens_hsa040240.60378944
103Non-homologous end-joining_Homo sapiens_hsa034500.59049252
104Pentose phosphate pathway_Homo sapiens_hsa000300.57902753
105Wnt signaling pathway_Homo sapiens_hsa043100.57559740
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57484526
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.56932708
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56104270
109Prion diseases_Homo sapiens_hsa050200.55955817
110Bile secretion_Homo sapiens_hsa049760.54166172
111Fatty acid biosynthesis_Homo sapiens_hsa000610.53232675
112VEGF signaling pathway_Homo sapiens_hsa043700.53168272
113Axon guidance_Homo sapiens_hsa043600.51398225
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49674214
115Fatty acid metabolism_Homo sapiens_hsa012120.49653941
116Fructose and mannose metabolism_Homo sapiens_hsa000510.48744927
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.48268642
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47938247
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.46190189
120Endometrial cancer_Homo sapiens_hsa052130.43885855
121* Endocytosis_Homo sapiens_hsa041440.43816922
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43423649
123MAPK signaling pathway_Homo sapiens_hsa040100.43166275
124* Central carbon metabolism in cancer_Homo sapiens_hsa052300.43111169
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42667062
126Rheumatoid arthritis_Homo sapiens_hsa053230.41792117
127Type I diabetes mellitus_Homo sapiens_hsa049400.41386621
128Dilated cardiomyopathy_Homo sapiens_hsa054140.40643650
129Sulfur metabolism_Homo sapiens_hsa009200.39052307
130Insulin resistance_Homo sapiens_hsa049310.38486573
131Arginine biosynthesis_Homo sapiens_hsa002200.37779432
132Rap1 signaling pathway_Homo sapiens_hsa040150.35497556
133Regulation of autophagy_Homo sapiens_hsa041400.35095266
134Lysosome_Homo sapiens_hsa041420.33727663
135Pyruvate metabolism_Homo sapiens_hsa006200.33651715
136Melanoma_Homo sapiens_hsa052180.33634550
137Inositol phosphate metabolism_Homo sapiens_hsa005620.33403168
138Choline metabolism in cancer_Homo sapiens_hsa052310.33238724
139Steroid biosynthesis_Homo sapiens_hsa001000.31962705

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