RETN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride catabolic process (GO:0019433)8.88928364
2white fat cell differentiation (GO:0050872)8.79702491
3regulation of sequestering of triglyceride (GO:0010889)8.62251783
4brown fat cell differentiation (GO:0050873)8.16076002
5neutral lipid catabolic process (GO:0046461)7.94732077
6acylglycerol catabolic process (GO:0046464)7.94732077
7valine metabolic process (GO:0006573)7.78527292
8biotin metabolic process (GO:0006768)7.38124320
9response to peptidoglycan (GO:0032494)7.26733669
10neutrophil activation involved in immune response (GO:0002283)6.87981017
11defense response to fungus (GO:0050832)6.61575376
12triglyceride biosynthetic process (GO:0019432)6.41567238
13detection of bacterium (GO:0016045)6.15016836
14detection of other organism (GO:0098543)6.14100915
15neutral lipid biosynthetic process (GO:0046460)6.10983973
16acylglycerol biosynthetic process (GO:0046463)6.10983973
17lipid particle organization (GO:0034389)6.10000771
18leukocyte migration involved in inflammatory response (GO:0002523)6.06411694
19glycerolipid catabolic process (GO:0046503)5.96668438
20regulation of cholesterol storage (GO:0010885)5.90368397
21leukocyte aggregation (GO:0070486)5.85746363
22negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.84906990
23cellular extravasation (GO:0045123)5.58516748
24fatty acid transmembrane transport (GO:1902001)5.41263482
25response to fungus (GO:0009620)5.40777431
26innate immune response in mucosa (GO:0002227)5.31571671
27positive regulation of fatty acid oxidation (GO:0046321)5.20727941
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)5.19542779
29long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)5.16277932
30fatty-acyl-CoA biosynthetic process (GO:0046949)5.12005153
31lipid storage (GO:0019915)5.11897840
32neutrophil activation (GO:0042119)5.11573997
33branched-chain amino acid metabolic process (GO:0009081)5.02260868
34positive regulation of fatty acid beta-oxidation (GO:0032000)5.00000614
35granulocyte activation (GO:0036230)4.97130231
36acyl-CoA biosynthetic process (GO:0071616)4.92970538
37thioester biosynthetic process (GO:0035384)4.92970538
38disruption of cells of other organism (GO:0044364)4.90530629
39killing of cells of other organism (GO:0031640)4.90530629
40fatty-acyl-CoA metabolic process (GO:0035337)4.89756308
41triglyceride metabolic process (GO:0006641)4.86293543
42branched-chain amino acid catabolic process (GO:0009083)4.84231732
43protein heterotrimerization (GO:0070208)4.79547243
44carnitine shuttle (GO:0006853)4.76512919
45negative regulation of protein autophosphorylation (GO:0031953)4.75505118
46mucosal immune response (GO:0002385)4.73504783
47negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.72745402
48response to dietary excess (GO:0002021)4.65297292
49negative regulation of granulocyte differentiation (GO:0030853)4.64560467
50detection of external biotic stimulus (GO:0098581)4.64541773
51organ or tissue specific immune response (GO:0002251)4.64423262
52antibacterial humoral response (GO:0019731)4.58529365
53fatty acid beta-oxidation (GO:0006635)4.57779395
54negative regulation of phagocytosis (GO:0050765)4.56710339
55acylglycerol metabolic process (GO:0006639)4.56089887
56regulation of mast cell degranulation (GO:0043304)4.55921482
57positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.51559537
58neutral lipid metabolic process (GO:0006638)4.49807730
59response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.47529858
60response to host immune response (GO:0052572)4.47529858
61negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.45899497
62antimicrobial humoral response (GO:0019730)4.44098555
63positive regulation of gamma-delta T cell activation (GO:0046645)4.41835350
64coenzyme A biosynthetic process (GO:0015937)4.36990610
65positive regulation of glomerulus development (GO:0090193)4.32738212
66respiratory burst (GO:0045730)4.31763317
67plasma lipoprotein particle clearance (GO:0034381)4.31674880
68fatty acid homeostasis (GO:0055089)4.30848940
69regulation of glycogen (starch) synthase activity (GO:2000465)4.30094188
70complement activation, alternative pathway (GO:0006957)4.29448890
71regulation of macrophage derived foam cell differentiation (GO:0010743)4.29364771
72negative regulation of interleukin-12 production (GO:0032695)4.29203941
73positive regulation of mast cell degranulation (GO:0043306)4.22743763
74positive regulation of mast cell activation involved in immune response (GO:0033008)4.22743763
75pentose-phosphate shunt (GO:0006098)4.22135462
76detection of biotic stimulus (GO:0009595)4.20928590
77regulation of mast cell activation involved in immune response (GO:0033006)4.20864102
78cellular response to lithium ion (GO:0071285)4.20563878
79regulation of cAMP-dependent protein kinase activity (GO:2000479)4.18696700
80negative regulation of lipid storage (GO:0010888)4.18135197
81positive regulation of mast cell activation (GO:0033005)4.17411868
82NADPH regeneration (GO:0006740)4.17280699
83disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.15490880
84killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.15490880
85negative regulation of macrophage differentiation (GO:0045650)4.15146072
86regulation of myeloid leukocyte mediated immunity (GO:0002886)4.12360236
87fatty acid oxidation (GO:0019395)4.09915886
88ovulation from ovarian follicle (GO:0001542)4.09004079
89positive regulation of fatty acid metabolic process (GO:0045923)4.07872704
90negative regulation of interleukin-8 production (GO:0032717)4.06151102
91regulation of leukocyte degranulation (GO:0043300)4.03377443
92lipid oxidation (GO:0034440)4.02531845
93response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.01228117
94response to host (GO:0075136)4.01228117
95response to host defenses (GO:0052200)4.01228117
96negative regulation of metanephros development (GO:0072217)4.00171413
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.99926436
98positive regulation by organism of defense response of other organism involved in symbiotic interact3.99926436
99modulation by symbiont of host immune response (GO:0052553)3.99926436
100positive regulation by symbiont of host defense response (GO:0052509)3.99926436
101modulation by symbiont of host defense response (GO:0052031)3.99926436
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.99926436
103macrophage activation involved in immune response (GO:0002281)3.98944541
104negative regulation of growth of symbiont in host (GO:0044130)3.98626620
105negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.98626620
106modulation of growth of symbiont involved in interaction with host (GO:0044144)3.98626620
107regulation of growth of symbiont in host (GO:0044126)3.98626620
108acetyl-CoA metabolic process (GO:0006084)3.98225072
109immunoglobulin mediated immune response (GO:0016064)3.97858241
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.97294361
111cellular response to epinephrine stimulus (GO:0071872)3.95726622
112regulation of mast cell activation (GO:0033003)3.95536418
113alpha-linolenic acid metabolic process (GO:0036109)3.91987504
114fatty acid catabolic process (GO:0009062)3.91156008
115carnitine transmembrane transport (GO:1902603)3.89775895
116positive regulation of glucose import (GO:0046326)3.86101284
117growth hormone receptor signaling pathway (GO:0060396)3.85545620
118negative regulation of gluconeogenesis (GO:0045721)3.85473795
119positive regulation of cellular response to insulin stimulus (GO:1900078)3.84630130
120L-serine transport (GO:0015825)3.84275039
121positive regulation of lipid catabolic process (GO:0050996)3.84194330
122positive regulation of cholesterol efflux (GO:0010875)3.83971364
123neutrophil chemotaxis (GO:0030593)3.81905369
124negative regulation of DNA biosynthetic process (GO:2000279)3.80118506
125positive regulation of sterol transport (GO:0032373)3.76332382
126positive regulation of cholesterol transport (GO:0032376)3.76332382
127regulation of fatty acid beta-oxidation (GO:0031998)3.74813475
128regulation of interleukin-8 biosynthetic process (GO:0045414)3.73970902
129production of molecular mediator involved in inflammatory response (GO:0002532)3.72584458
130neutrophil migration (GO:1990266)3.72443653
131myeloid cell activation involved in immune response (GO:0002275)3.72326062
132response to muramyl dipeptide (GO:0032495)3.72096964
133regulation of fatty acid oxidation (GO:0046320)3.71415140
134tricarboxylic acid metabolic process (GO:0072350)3.68167044
135negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.67795664
136regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.67313246
137defense response to Gram-positive bacterium (GO:0050830)3.64622272
138positive regulation of lipid storage (GO:0010884)3.63686288
139CDP-diacylglycerol biosynthetic process (GO:0016024)3.63393212
140negative regulation of interleukin-6 production (GO:0032715)3.61343372
141superoxide anion generation (GO:0042554)3.60896343
142adaptation of signaling pathway (GO:0023058)3.59352917
143positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.57777811
144amino-acid betaine transport (GO:0015838)3.56525624
145carnitine transport (GO:0015879)3.56525624
146diacylglycerol metabolic process (GO:0046339)3.56044335
147negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54273160
148negative regulation of cell killing (GO:0031342)3.54273160
149regulation of regulated secretory pathway (GO:1903305)3.51282291
150oxaloacetate metabolic process (GO:0006107)3.50435689
151regulation of triglyceride metabolic process (GO:0090207)3.49906079
152phagosome maturation (GO:0090382)3.48546969
153negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.48139331
154negative regulation of erythrocyte differentiation (GO:0045647)3.47323392
155leukocyte degranulation (GO:0043299)3.46898464
156glycerol metabolic process (GO:0006071)3.46571117
157regulation of triglyceride biosynthetic process (GO:0010866)3.45542964
158regulation of triglyceride catabolic process (GO:0010896)3.45425292
159positive regulation of toll-like receptor signaling pathway (GO:0034123)3.44740711
160neutrophil mediated immunity (GO:0002446)3.42640628
161cellular response to growth hormone stimulus (GO:0071378)3.42230087
162positive regulation of leukocyte degranulation (GO:0043302)3.39063660
163retina vasculature morphogenesis in camera-type eye (GO:0061299)3.38698580
164regulation of lipid storage (GO:0010883)3.38463271
165coenzyme A metabolic process (GO:0015936)3.36363107
166serine transport (GO:0032329)3.34735308
167detection of molecule of bacterial origin (GO:0032490)3.34616264
168negative regulation of smooth muscle cell migration (GO:0014912)3.34503244
169regulation of receptor binding (GO:1900120)3.33726518
170positive regulation of insulin receptor signaling pathway (GO:0046628)3.32566596
171lipopolysaccharide-mediated signaling pathway (GO:0031663)3.30363031
172positive regulation of glucose transport (GO:0010828)3.29490616
173granulocyte migration (GO:0097530)3.28863166
174mast cell activation (GO:0045576)3.27740103
175macrophage activation (GO:0042116)3.26606257
176phosphatidic acid biosynthetic process (GO:0006654)3.26570544
177phosphatidic acid metabolic process (GO:0046473)3.26570544
178granulocyte chemotaxis (GO:0071621)3.19768672
179positive regulation of regulated secretory pathway (GO:1903307)3.18597520
180microglial cell activation (GO:0001774)3.18272315
181regulation of B cell receptor signaling pathway (GO:0050855)3.17044366
182antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13067752
183cell killing (GO:0001906)3.12270651
184chronic inflammatory response (GO:0002544)3.08778728
185defense response to bacterium (GO:0042742)3.08066979
186myeloid leukocyte activation (GO:0002274)3.07870105
187regulation of gamma-delta T cell activation (GO:0046643)3.04404813
188B cell mediated immunity (GO:0019724)3.01456660
189regulation of T-helper 2 cell differentiation (GO:0045628)2.94606617
190regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.94210306
191regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.94108855
192reactive oxygen species biosynthetic process (GO:1903409)2.93391096
193positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.92151705
194negative regulation of cytokine production involved in immune response (GO:0002719)2.91978197
195negative regulation of tumor necrosis factor production (GO:0032720)2.89955547
196myeloid leukocyte mediated immunity (GO:0002444)2.87420071
197negative regulation of lymphocyte mediated immunity (GO:0002707)2.87155641
198response to bacterium (GO:0009617)2.86611704
199sequestering of metal ion (GO:0051238)2.85971487
200low-density lipoprotein particle clearance (GO:0034383)10.6146416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.79052181
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.55492368
3CLOCK_20551151_ChIP-Seq_293T_Human4.85256421
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.23954267
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.85032606
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65826233
7VDR_21846776_ChIP-Seq_THP-1_Human3.52007395
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.50811980
9* VDR_24763502_ChIP-Seq_THP-1_Human3.30426947
10* SPI1_23547873_ChIP-Seq_NB4_Human3.06337486
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.99281964
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.95235563
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.71486592
14SCL_19346495_ChIP-Seq_HPC-7_Human2.64425997
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60276472
16* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.59130383
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.58853953
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54656094
19SPI1_23127762_ChIP-Seq_K562_Human2.51239369
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.46511374
21ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.45912379
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.43973748
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38281407
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.36588541
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.34531489
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.25922927
27STAT4_19710469_ChIP-ChIP_TH1__Mouse2.25684129
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24018323
29* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.18895395
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12335755
31MAF_26560356_Chip-Seq_TH1_Human2.08836335
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.08035317
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07077770
34PPARA_22158963_ChIP-Seq_LIVER_Mouse2.06919978
35* PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.8256886
36CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.99517358
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99508469
38MYB_26560356_Chip-Seq_TH2_Human1.97582981
39GATA1_22025678_ChIP-Seq_K562_Human1.93815264
40UTX_26944678_Chip-Seq_JUKART_Human1.93238903
41MYC_22102868_ChIP-Seq_BL_Human1.90068979
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88540043
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86297574
44TCF7_22412390_ChIP-Seq_EML_Mouse1.82708762
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.81232571
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81199921
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.81151360
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80877770
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78486904
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.77208052
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.76205780
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.69906943
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.69774311
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69212014
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.61938933
56GATA1_19941827_ChIP-Seq_MEL_Mouse1.59961171
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59868520
58TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59264231
59* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56727342
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55745267
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55329468
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55047186
63MYB_26560356_Chip-Seq_TH1_Human1.54899794
64KDM2B_26808549_Chip-Seq_DND41_Human1.53335708
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51850575
66LXR_22292898_ChIP-Seq_THP-1_Human1.51312219
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50902156
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47342691
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.46911548
70PU_27001747_Chip-Seq_BMDM_Mouse1.45986258
71GATA2_22383799_ChIP-Seq_G1ME_Mouse1.45978886
72MAF_26560356_Chip-Seq_TH2_Human1.45299933
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45258372
74CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43108888
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41610541
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41463751
77* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38816297
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36661212
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32992484
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28781860
81BCOR_27268052_Chip-Seq_Bcells_Human1.27652053
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24387984
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24072907
84IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24023798
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23668235
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.21840062
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.21840062
88GATA3_27048872_Chip-Seq_THYMUS_Human1.21095889
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20536023
90CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19806037
91BCL6_27268052_Chip-Seq_Bcells_Human1.19678958
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19602850
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18778417
94GATA3_26560356_Chip-Seq_TH2_Human1.16205125
95ZNF263_19887448_ChIP-Seq_K562_Human1.14780169
96CJUN_26792858_Chip-Seq_BT549_Human1.14469439
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11224020
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11037542
99TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10272597
100PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09932393
101ELF1_17652178_ChIP-ChIP_JURKAT_Human1.08878962
102SPI1_20517297_ChIP-Seq_HL60_Human1.08421315
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.08150489
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08107119
105NCOR1_26117541_ChIP-Seq_K562_Human1.07980014
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.06196582
107TFEB_21752829_ChIP-Seq_HELA_Human1.04315444
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.01879985
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01826889
110IRF8_22096565_ChIP-ChIP_GC-B_Human1.01396033
111RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99551281
112ESR2_21235772_ChIP-Seq_MCF-7_Human0.98847960
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98657485
114* VDR_24787735_ChIP-Seq_THP-1_Human0.97282906
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.94324776
116ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92229950
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91646169
118CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91221133
119TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90130555
120KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89781404
121SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89657311
122STAT1_20625510_ChIP-Seq_HELA_Human0.89498830
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89115644
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88337421
125IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.87028962
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86573163
127SALL1_21062744_ChIP-ChIP_HESCs_Human0.86474544
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.84166789
129TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83372704
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83101757
131GATA1_19941826_ChIP-Seq_K562_Human0.82095642
132RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80747729
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80747729
134EP300_21415370_ChIP-Seq_HL-1_Mouse0.80592734
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79881417
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78670621
137NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78670621
138PIAS1_25552417_ChIP-Seq_VCAP_Human0.77967066
139SOX2_20726797_ChIP-Seq_SW620_Human0.77258567
140RXR_22108803_ChIP-Seq_LS180_Human0.74872729
141P300_27058665_Chip-Seq_ZR-75-30cells_Human0.74737577
142EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74503127
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73947794
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.73773074
145MYB_21317192_ChIP-Seq_ERMYB_Mouse0.73130425
146ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.72910735
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67751889
148SALL4_18804426_ChIP-ChIP_XEN_Mouse0.66700818
149SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65245483
150ESR1_20079471_ChIP-ChIP_T-47D_Human0.64977484
151GATA3_24758297_ChIP-Seq_MCF-7_Human0.64251700
152THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.64239439
153SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64179383
154FOXA2_19822575_ChIP-Seq_HepG2_Human0.63367900
155ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63145676
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.62593768
157WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.62515908
158* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61976594
159GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61886303
160GATA2_19941826_ChIP-Seq_K562_Human0.61492722
161ELK3_25401928_ChIP-Seq_HUVEC_Human0.60087034
162SMAD_19615063_ChIP-ChIP_OVARY_Human0.59103167
163NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.59017833
164BCAT_22108803_ChIP-Seq_LS180_Human0.58027327
165RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57567989
166JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57151529
167CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56795619
168GATA3_21878914_ChIP-Seq_MCF-7_Human0.55769681
169CEBPB_22108803_ChIP-Seq_LS180_Human0.55111223
170RUNX_20019798_ChIP-Seq_JUKART_Human0.54794136
171NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.54727880
172FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.54157608
173KLF4_19829295_ChIP-Seq_ESCs_Human0.52976931
174JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.52856807
175SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.52649072
176KDM2B_26808549_Chip-Seq_K562_Human0.52219344
177RACK7_27058665_Chip-Seq_MCF-7_Human0.52072422
178* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.52053593
179ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.51260244

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.34211436
2MP0005666_abnormal_adipose_tissue5.63370091
3MP0004185_abnormal_adipocyte_glucose5.19929660
4MP0004130_abnormal_muscle_cell5.16806840
5MP0003303_peritoneal_inflammation4.43943348
6MP0008438_abnormal_cutaneous_collagen4.43677108
7MP0003436_decreased_susceptibility_to4.25746229
8MP0005375_adipose_tissue_phenotype4.10794055
9MP0009785_altered_susceptibility_to3.57424309
10MP0002419_abnormal_innate_immunity3.53840705
11MP0002876_abnormal_thyroid_physiology3.42981457
12MP0000013_abnormal_adipose_tissue3.18729533
13MP0002837_dystrophic_cardiac_calcinosis3.17248223
14MP0005025_abnormal_response_to3.16637670
15MP0001835_abnormal_antigen_presentation3.15808481
16MP0002971_abnormal_brown_adipose3.09886530
17MP0006082_CNS_inflammation3.06340787
18MP0005275_abnormal_skin_tensile2.96723320
19MP0003172_abnormal_lysosome_physiology2.92951714
20MP0002148_abnormal_hypersensitivity_rea2.85117015
21MP0010329_abnormal_lipoprotein_level2.81987438
22MP0009115_abnormal_fat_cell2.78825748
23MP0005000_abnormal_immune_tolerance2.74040042
24MP0000003_abnormal_adipose_tissue2.73558972
25MP0005334_abnormal_fat_pad2.64298787
26MP0005387_immune_system_phenotype2.53991073
27MP0001790_abnormal_immune_system2.53991073
28MP0000685_abnormal_immune_system2.41036614
29MP0002452_abnormal_antigen_presenting2.38096412
30MP0005464_abnormal_platelet_physiology2.35652567
31MP0001800_abnormal_humoral_immune2.34653348
32MP0003191_abnormal_cellular_cholesterol2.34203627
33MP0005671_abnormal_response_to2.34121735
34MP0001661_extended_life_span2.33325266
35MP0002420_abnormal_adaptive_immunity2.33048991
36MP0002723_abnormal_immune_serum2.32759208
37MP0001819_abnormal_immune_cell2.30405550
38MP0009278_abnormal_bone_marrow2.29895584
39MP0003300_gastrointestinal_ulcer2.27182706
40MP0002970_abnormal_white_adipose2.22811593
41MP0003075_altered_response_to2.03097991
42MP0003959_abnormal_lean_body1.97857879
43MP0002405_respiratory_system_inflammati1.93232744
44MP0001845_abnormal_inflammatory_respons1.92588743
45MP0001545_abnormal_hematopoietic_system1.89817006
46MP0005397_hematopoietic_system_phenotyp1.89817006
47MP0005535_abnormal_body_temperature1.87824647
48* MP0002118_abnormal_lipid_homeostasis1.85681563
49MP0003724_increased_susceptibility_to1.85633476
50MP0008260_abnormal_autophagy1.84117570
51MP0003806_abnormal_nucleotide_metabolis1.80873086
52MP0009764_decreased_sensitivity_to1.77679740
53MP0003705_abnormal_hypodermis_morpholog1.77399658
54MP0003656_abnormal_erythrocyte_physiolo1.75273479
55MP0004272_abnormal_basement_membrane1.72914541
56MP0002138_abnormal_hepatobiliary_system1.72580442
57MP0003186_abnormal_redox_activity1.70357207
58MP0004510_myositis1.69467850
59MP0000716_abnormal_immune_system1.67599496
60MP0002398_abnormal_bone_marrow1.63257324
61MP0001881_abnormal_mammary_gland1.61506941
62MP0010155_abnormal_intestine_physiology1.56236220
63MP0005448_abnormal_energy_balance1.55566899
64MP0009840_abnormal_foam_cell1.54432356
65MP0008469_abnormal_protein_level1.53390878
66MP0004947_skin_inflammation1.53327510
67MP0001851_eye_inflammation1.50831494
68MP0005452_abnormal_adipose_tissue1.47447506
69MP0003690_abnormal_glial_cell1.46973975
70MP0003828_pulmonary_edema1.43457886
71MP0000689_abnormal_spleen_morphology1.41322926
72MP0009333_abnormal_splenocyte_physiolog1.40411448
73MP0002429_abnormal_blood_cell1.38171669
74MP0002722_abnormal_immune_system1.35130761
75MP0000465_gastrointestinal_hemorrhage1.34327428
76MP0005310_abnormal_salivary_gland1.30683154
77MP0001501_abnormal_sleep_pattern1.30541000
78MP0006138_congestive_heart_failure1.27899302
79MP0005166_decreased_susceptibility_to1.21008931
80* MP0000609_abnormal_liver_physiology1.16903328
81MP0000604_amyloidosis1.16829097
82MP0002060_abnormal_skin_morphology1.16144402
83MP0002796_impaired_skin_barrier1.14650750
84* MP0002078_abnormal_glucose_homeostasis1.13913207
85MP0008004_abnormal_stomach_pH1.12698586
86MP0002254_reproductive_system_inflammat1.12118652
87MP0003763_abnormal_thymus_physiology1.11507962
88MP0005365_abnormal_bile_salt1.11196039
89MP0000343_altered_response_to1.10527042
90MP0008775_abnormal_heart_ventricle1.09648501
91MP0002166_altered_tumor_susceptibility1.08598850
92MP0005164_abnormal_response_to1.04171289
93MP0002132_abnormal_respiratory_system1.04118850
94MP0001727_abnormal_embryo_implantation1.03705165
95MP0009780_abnormal_chondrocyte_physiolo1.03704487
96MP0004883_abnormal_blood_vessel1.03443754
97MP0003183_abnormal_peptide_metabolism1.01089984
98MP0000751_myopathy0.95096914
99MP0000750_abnormal_muscle_regeneration0.94964107
100MP0002638_abnormal_pupillary_reflex0.94378826
101MP0001764_abnormal_homeostasis0.93450693
102MP0005390_skeleton_phenotype0.92570280
103MP0002909_abnormal_adrenal_gland0.90754287
104MP0003566_abnormal_cell_adhesion0.89636614
105MP0004147_increased_porphyrin_level0.89390396
106MP0001663_abnormal_digestive_system0.87936310
107MP0003045_fibrosis0.86945896
108MP0002006_tumorigenesis0.86598612
109MP0005620_abnormal_muscle_contractility0.86204774
110MP0005385_cardiovascular_system_phenoty0.85053639
111MP0001544_abnormal_cardiovascular_syste0.85053639
112MP0000703_abnormal_thymus_morphology0.84715695
113MP0005076_abnormal_cell_differentiation0.84453330
114MP0004808_abnormal_hematopoietic_stem0.83778587
115MP0003950_abnormal_plasma_membrane0.82929546
116MP0003646_muscle_fatigue0.82248141
117MP0005645_abnormal_hypothalamus_physiol0.80711539
118MP0005451_abnormal_body_composition0.80114397
119MP0009765_abnormal_xenobiotic_induced0.79326431
120MP0005167_abnormal_blood-brain_barrier0.78914817
121MP0005584_abnormal_enzyme/coenzyme_acti0.78393025
122MP0003948_abnormal_gas_homeostasis0.77797109
123MP0003795_abnormal_bone_structure0.77730573
124MP0001756_abnormal_urination0.77370470
125MP0005379_endocrine/exocrine_gland_phen0.75925476
126MP0003953_abnormal_hormone_level0.73994767
127MP0001177_atelectasis0.73328615
128MP0003866_abnormal_defecation0.72882755
129MP0005165_increased_susceptibility_to0.72016495
130MP0003221_abnormal_cardiomyocyte_apopto0.70471180
131MP0002396_abnormal_hematopoietic_system0.69847425
132MP0005319_abnormal_enzyme/_coenzyme0.68751363
133MP0000759_abnormal_skeletal_muscle0.68341230
134MP0006054_spinal_hemorrhage0.67380409
135MP0002168_other_aberrant_phenotype0.66666569
136MP0004087_abnormal_muscle_fiber0.66514141
137MP0000920_abnormal_myelination0.66310024
138MP0002277_abnormal_respiratory_mucosa0.65879279
139MP0001873_stomach_inflammation0.65249941
140MP0002139_abnormal_hepatobiliary_system0.64497645
141MP0009643_abnormal_urine_homeostasis0.63974949
142MP0006036_abnormal_mitochondrial_physio0.63901484
143MP0000490_abnormal_crypts_of0.63885925
144MP0001533_abnormal_skeleton_physiology0.63557771
145MP0005083_abnormal_biliary_tract0.61549327
146MP0002877_abnormal_melanocyte_morpholog0.60502859
147MP0000427_abnormal_hair_cycle0.60334781
148MP0001542_abnormal_bone_strength0.59619403
149MP0002133_abnormal_respiratory_system0.58498508
150MP0005388_respiratory_system_phenotype0.58498508
151MP0008961_abnormal_basal_metabolism0.58332475
152MP0000249_abnormal_blood_vessel0.58163451
153MP0001879_abnormal_lymphatic_vessel0.58054171
154MP0009672_abnormal_birth_weight0.57986700
155MP0009763_increased_sensitivity_to0.57250600
156MP0003448_altered_tumor_morphology0.57150496
157MP0003453_abnormal_keratinocyte_physiol0.56565212
158MP0000858_altered_metastatic_potential0.56182365
159MP0002972_abnormal_cardiac_muscle0.56041111
160MP0001986_abnormal_taste_sensitivity0.55726324
161MP0005595_abnormal_vascular_smooth0.55320406
162MP0003091_abnormal_cell_migration0.55146701
163MP0001853_heart_inflammation0.54561032
164MP0002332_abnormal_exercise_endurance0.54409036
165MP0000230_abnormal_systemic_arterial0.54023064
166MP0005647_abnormal_sex_gland0.53690586
167MP0005058_abnormal_lysosome_morphology0.53378360
168MP0005075_abnormal_melanosome_morpholog0.52143632
169MP0002295_abnormal_pulmonary_circulatio0.51445309
170MP0008874_decreased_physiological_sensi0.51037225
171MP0000015_abnormal_ear_pigmentation0.49270250
172MP0000627_abnormal_mammary_gland0.47141120
173MP0002998_abnormal_bone_remodeling0.46219016
174MP0005332_abnormal_amino_acid0.45712914
175MP0004782_abnormal_surfactant_physiolog0.45180757
176MP0002108_abnormal_muscle_morphology0.44980215
177MP0005360_urolithiasis0.43388724
178MP0004215_abnormal_myocardial_fiber0.43368590
179MP0001958_emphysema0.42165569

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)9.53318507
2Acanthosis nigricans (HP:0000956)7.95256903
3Hypertriglyceridemia (HP:0002155)7.12902118
4Recurrent abscess formation (HP:0002722)6.16451198
5Eczematoid dermatitis (HP:0000976)6.08665908
6Abnormality of macrophages (HP:0004311)5.92443144
7Recurrent bacterial skin infections (HP:0005406)5.86889212
8Hyperglycinuria (HP:0003108)5.78788996
9Complement deficiency (HP:0004431)5.59439443
10Insulin-resistant diabetes mellitus (HP:0000831)5.26677073
11Abnormality of liposaccharide metabolism (HP:0010968)5.20205892
12Abnormality of glycosphingolipid metabolism (HP:0004343)5.20205892
13Abnormality of glycolipid metabolism (HP:0010969)5.20205892
14Recurrent gram-negative bacterial infections (HP:0005420)5.14489190
15Stomatitis (HP:0010280)4.75212350
16Abnormality of glycine metabolism (HP:0010895)4.68270762
17Abnormality of serine family amino acid metabolism (HP:0010894)4.68270762
18Increased cerebral lipofuscin (HP:0011813)4.66363005
19Long foot (HP:0001833)4.48949365
20Obstructive lung disease (HP:0006536)4.36590398
21Chronic obstructive pulmonary disease (HP:0006510)4.36590398
22Myositis (HP:0100614)4.34284954
23Difficulty running (HP:0009046)4.26826147
24Increased neuronal autofluorescent lipopigment (HP:0002074)4.12643932
25Mediastinal lymphadenopathy (HP:0100721)4.09747234
26Abnormality of complement system (HP:0005339)4.03936791
27Reduced subcutaneous adipose tissue (HP:0003758)4.00119546
28Growth hormone excess (HP:0000845)3.96921013
29Insulin resistance (HP:0000855)3.89678252
30Orchitis (HP:0100796)3.67095219
31Elevated erythrocyte sedimentation rate (HP:0003565)3.65861893
32Recurrent skin infections (HP:0001581)3.63737561
33Disinhibition (HP:0000734)3.63251232
34Pigmentary retinal degeneration (HP:0001146)3.62476301
35Vacuolated lymphocytes (HP:0001922)3.52107526
36Recurrent fungal infections (HP:0002841)3.51915832
37Retrobulbar optic neuritis (HP:0100654)3.50723855
38Optic neuritis (HP:0100653)3.50723855
39Thyroid-stimulating hormone excess (HP:0002925)3.49244795
40Bone cyst (HP:0012062)3.45187805
41Petechiae (HP:0000967)3.43499770
42Hyperthyroidism (HP:0000836)3.41428561
43Dysostosis multiplex (HP:0000943)3.38399801
44Gingivitis (HP:0000230)3.37505331
45Epidermoid cyst (HP:0200040)3.37235412
46Hypochromic microcytic anemia (HP:0004840)3.36932641
47Subcapsular cataract (HP:0000523)3.36699462
48Multiple enchondromatosis (HP:0005701)3.35405031
49Myoglobinuria (HP:0002913)3.34355999
50Increased muscle lipid content (HP:0009058)3.33799068
51Hydroxyprolinuria (HP:0003080)3.33674777
52Abnormality of proline metabolism (HP:0010907)3.33674777
53Increased connective tissue (HP:0009025)3.32091485
54Meningitis (HP:0001287)3.32064840
55Ankle contracture (HP:0006466)3.27405795
56Hypoalphalipoproteinemia (HP:0003233)3.24451858
57Loss of speech (HP:0002371)3.24036534
58Urticaria (HP:0001025)3.22528529
59Myocardial infarction (HP:0001658)3.17307802
60Hemorrhage of the eye (HP:0011885)3.16363885
61Abnormal delayed hypersensitivity skin test (HP:0002963)3.11669893
62Prolonged bleeding time (HP:0003010)3.11299445
63Hyperpituitarism (HP:0010514)3.09499999
64Large hands (HP:0001176)3.05946393
65Abnormality of fatty-acid metabolism (HP:0004359)3.03628709
66Follicular hyperkeratosis (HP:0007502)3.03436871
67Abnormality of the heme biosynthetic pathway (HP:0010472)2.99841189
68Type 1 muscle fiber predominance (HP:0003803)2.98689195
69Ketoacidosis (HP:0001993)2.96459401
70Chronic mucocutaneous candidiasis (HP:0002728)2.93969877
71Recurrent cutaneous fungal infections (HP:0011370)2.93969877
72Pancreatitis (HP:0001733)2.92271850
73Nausea (HP:0002018)2.90708453
74Mutism (HP:0002300)2.89460080
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.86690748
76Hyperlipoproteinemia (HP:0010980)2.86420287
77Broad metatarsal (HP:0001783)2.85078182
78Episodic fever (HP:0001954)2.80873561
79Ketosis (HP:0001946)2.80320019
80Purpura (HP:0000979)2.79233173
81Increased serum ferritin (HP:0003281)2.78383992
82Epistaxis (HP:0000421)2.75316162
83Gastrointestinal infarctions (HP:0005244)2.74833157
84Keratoconjunctivitis sicca (HP:0001097)2.74478717
85Increased IgE level (HP:0003212)2.74267599
86Increased variability in muscle fiber diameter (HP:0003557)2.72733118
87Pulmonary infiltrates (HP:0002113)2.72304949
88Vasculitis (HP:0002633)2.71558017
89Hyperglycinemia (HP:0002154)2.71433986
90Systemic lupus erythematosus (HP:0002725)2.69560011
91Hypoglycemic coma (HP:0001325)2.68821148
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.67847829
93Spinal rigidity (HP:0003306)2.67500848
94Abnormality of iron homeostasis (HP:0011031)2.67235417
95Accelerated skeletal maturation (HP:0005616)2.66633021
96Cellulitis (HP:0100658)2.64052149
97Hypochromic anemia (HP:0001931)2.61910439
98Hemoptysis (HP:0002105)2.61213830
99Spontaneous hematomas (HP:0007420)2.58861725
100Encephalitis (HP:0002383)2.58043147
101Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.57992632
102Anorexia (HP:0002039)2.56437200
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56284223
104Abnormality of polysaccharide metabolism (HP:0011012)2.56284223
105Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56284223
106Rhabdomyolysis (HP:0003201)2.55576401
107Autoimmune thrombocytopenia (HP:0001973)2.54972350
108Cerebral aneurysm (HP:0004944)2.53863292
109Keratoconjunctivitis (HP:0001096)2.53215412
110Skin nodule (HP:0200036)2.49193050
111Prenatal maternal abnormality (HP:0002686)2.49169786
112Recurrent viral infections (HP:0004429)2.47911591
113Toxemia of pregnancy (HP:0100603)2.46364226
114Slender build (HP:0001533)2.45658766
115Osteomyelitis (HP:0002754)2.45314583
116Abnormal cartilage morphology (HP:0002763)2.45273770
117Prominent supraorbital ridges (HP:0000336)2.45206317
118Aortic dissection (HP:0002647)2.44336126
119Decreased subcutaneous fat (HP:0001002)2.43696736
120Tetraparesis (HP:0002273)2.42693606
121Hyperammonemia (HP:0001987)2.41424322
122Lipoatrophy (HP:0100578)2.39569413
123Urinary glycosaminoglycan excretion (HP:0003541)2.37939924
124Mucopolysacchariduria (HP:0008155)2.37939924
125Progressive neurologic deterioration (HP:0002344)2.37044399
126Abnormal hemoglobin (HP:0011902)2.35580638
127Leukocytosis (HP:0001974)2.35438873
128Gingival bleeding (HP:0000225)2.33612002
129Upper motor neuron abnormality (HP:0002127)2.32743204
130Xanthomatosis (HP:0000991)2.31329349
131Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31063048
132Facial diplegia (HP:0001349)2.28736376
133Abnormal eating behavior (HP:0100738)2.28644819
134Abnormality of skeletal muscle fiber size (HP:0012084)2.27843594
135Microcytic anemia (HP:0001935)2.27366139
136Polygenic inheritance (HP:0010982)2.24400486
137Chest pain (HP:0100749)2.23746056
138Pustule (HP:0200039)2.21538719
139Granulocytopenia (HP:0001913)2.19650508
140Polyphagia (HP:0002591)2.18709582
141Hypercholesterolemia (HP:0003124)2.18495438
142Axonal loss (HP:0003447)2.17621785
143Abnormality of subcutaneous fat tissue (HP:0001001)2.17450246
144Abnormality of transition element cation homeostasis (HP:0011030)2.16662396
145Muscle fiber splitting (HP:0003555)2.16024966
146Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15608921
147Dicarboxylic aciduria (HP:0003215)2.15608921
148Premature rupture of membranes (HP:0001788)2.13041701
149Hyperglycemia (HP:0003074)2.12492040
150Glomerulonephritis (HP:0000099)2.10414674
151Interstitial pulmonary disease (HP:0006530)2.08776193
152Polar cataract (HP:0010696)2.08774680
153Abnormality of the vasculature of the conjunctiva (HP:0008054)2.07811997
154Neuronal loss in central nervous system (HP:0002529)2.07787330
155Polycythemia (HP:0001901)2.07377375
156Pulmonary embolism (HP:0002204)2.05801316
157Clitoromegaly (HP:0000057)2.04596357
158Hypergammaglobulinemia (HP:0010702)2.03784126
159Inflammation of the large intestine (HP:0002037)2.02662531
160Gangrene (HP:0100758)2.02375301
161Venous abnormality (HP:0002624)2.02020812
162Testicular atrophy (HP:0000029)2.01850872
163Diminished motivation (HP:0000745)2.01736264
164Aortic aneurysm (HP:0004942)2.01373707
165Right ventricular cardiomyopathy (HP:0011663)1.99830722
166Agnosia (HP:0010524)1.99805672
167Arterial thrombosis (HP:0004420)1.98909503
168Stridor (HP:0010307)1.98660601
169Hypercortisolism (HP:0001578)1.98590084
170Fibular hypoplasia (HP:0003038)1.94391331
171Apathy (HP:0000741)1.94200045
172Personality changes (HP:0000751)1.93390687
173Abnormality of the pleura (HP:0002103)1.93181407
174Polyneuropathy (HP:0001271)1.92963814
175Gastrointestinal inflammation (HP:0004386)1.91558454
176Increased IgM level (HP:0003496)1.91167328
177Amyloidosis (HP:0011034)1.90430664
178Pathologic fracture (HP:0002756)1.89296093
179Enlarged penis (HP:0000040)1.89088003
180Inappropriate behavior (HP:0000719)1.88792602
181Sepsis (HP:0100806)1.88698230
182Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88094609
183Abnormality of alanine metabolism (HP:0010916)1.88094609
184Hyperalaninemia (HP:0003348)1.88094609
185Neck muscle weakness (HP:0000467)1.86869093
186Abnormal platelet volume (HP:0011876)1.86754669
187Gonadotropin excess (HP:0000837)1.85990647
188Hyporeflexia of lower limbs (HP:0002600)1.85640891
189Colitis (HP:0002583)1.85413235
190Glucose intolerance (HP:0000833)1.82815673
191Proximal amyotrophy (HP:0007126)1.78582946
192Muscle stiffness (HP:0003552)1.78049716
193Congenital, generalized hypertrichosis (HP:0004540)1.75041310
194Hepatosplenomegaly (HP:0001433)1.74977900
195Abnormality of purine metabolism (HP:0004352)1.73794099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D7.46676749
2CAMK1G5.42197434
3TRIB35.21086432
4RIPK45.00969342
5SIK14.55085125
6BLK4.22297191
7BCKDK4.11718951
8PRPF4B3.04607295
9PDK42.83466436
10PDK32.83466436
11MST1R2.65168683
12LMTK22.62877871
13GRK62.54435647
14IRAK42.49289592
15TAOK12.46673676
16FES2.41595859
17RIPK12.34994302
18ERN12.30456311
19MAP4K12.26147899
20MAP3K112.16143604
21ZAP702.11089825
22FGR1.98716401
23MAP3K141.90409411
24PRKAA21.89937145
25BTK1.83444196
26SYK1.74863267
27CDK91.74547737
28PDK21.70228051
29TBK11.68283835
30INSRR1.58892190
31EPHB21.57948424
32FGFR31.52641047
33LYN1.49240377
34FGFR21.43095861
35BMPR21.39674263
36HCK1.39304747
37PIK3CA1.34604842
38MYLK1.32435933
39IKBKB1.27590891
40IKBKE1.27134178
41CDK61.23495718
42TESK21.23428091
43MAP3K11.22577256
44FRK1.20535555
45SIK31.20038291
46KIT1.15476778
47TXK1.15360591
48MAP2K11.11170390
49PDGFRA1.09027834
50MATK1.07901600
51MARK31.07392151
52IRAK31.07257228
53GRK71.04777369
54MAP3K51.04232396
55MAP3K131.02430620
56ITK0.99352218
57CDK190.99218160
58MET0.98879341
59JAK10.98342508
60TGFBR20.98328047
61PRKD30.97503694
62DDR20.94079636
63LCK0.92975044
64PRKAA10.92531264
65MAP3K60.91961566
66TIE10.83972920
67LATS10.83439780
68YES10.81417011
69PHKG10.81261063
70PHKG20.81261063
71FGFR40.81191485
72PKN20.80779355
73KSR20.80507486
74MAP2K30.79059862
75JAK20.79026737
76MOS0.78354292
77MARK20.76022937
78MAP2K60.73968197
79FER0.73886585
80NME20.73330635
81CAMK10.72519039
82TTN0.69492689
83SIK20.68570570
84NEK90.68544829
85PDPK10.68314312
86PRKCH0.67270972
87IGF1R0.66477259
88JAK30.65672000
89EIF2AK20.64513913
90ILK0.63567079
91PRKACG0.61548344
92GSK3A0.60972342
93CAMKK20.60678179
94PTK2B0.59729895
95STK100.58154754
96RPS6KL10.57736761
97RPS6KC10.57736761
98MAPK70.55033442
99FYN0.53911721
100PAK20.53776057
101LATS20.53161326
102RET0.52274131
103MAPK110.51933119
104PIM10.51234067
105PDK10.51179656
106PDGFRB0.51141359
107TNK20.48808688
108FGFR10.47471981
109RPS6KA60.47467371
110PINK10.47244851
111CDK40.45806606
112MTOR0.45425177
113HIPK20.44157175
114INSR0.44132814
115CLK10.43597063
116TEC0.42630411
117TAOK30.42325063
118IRAK10.41602689
119FLT30.41361567
120BMX0.40842262
121MAPKAPK20.40478206
122IRAK20.40271649
123PRKD10.39797789
124CDC42BPA0.39168175
125PRKG20.38105143
126MAP3K30.37150656
127PRKD20.36474942
128PRKCD0.36234513
129RPS6KB10.34977665
130CSK0.34956310
131MAPK120.34335334
132DAPK20.33421207
133ABL20.33062307
134SRC0.32613362
135EPHB10.29428757
136PTK60.28714208
137CSF1R0.28561352
138MAP2K40.27111377
139PIK3CG0.26740776
140MAP3K80.26314413
141PRKCQ0.25632054
142STK110.24931952
143CHUK0.23553876
144RPS6KA20.23494575
145TAOK20.23361660
146ABL10.22786748
147ALK0.22630559
148AKT10.20177148
149LRRK20.19440869
150EPHA30.19376608
151TRPM70.18519794
152NLK0.15376895
153MAPK40.13345258
154MAPK30.13273474
155TYK20.12425195
156PRKACA0.12123516
157PRKCZ0.12020274
158STK30.10873663
159DAPK30.10535855
160MAPKAPK30.10461298

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.41454279
2Regulation of lipolysis in adipocytes_Homo sapiens_hsa049234.84644076
3Propanoate metabolism_Homo sapiens_hsa006404.67086744
4PPAR signaling pathway_Homo sapiens_hsa033204.58112103
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.97934664
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.59753557
7Glycerolipid metabolism_Homo sapiens_hsa005613.43629947
8Fatty acid metabolism_Homo sapiens_hsa012123.37760118
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.16574339
10Osteoclast differentiation_Homo sapiens_hsa043803.10398806
11Leishmaniasis_Homo sapiens_hsa051403.05893167
12Asthma_Homo sapiens_hsa053103.02851530
13Other glycan degradation_Homo sapiens_hsa005112.92838206
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.54313494
15Fatty acid degradation_Homo sapiens_hsa000712.46469198
16Tuberculosis_Homo sapiens_hsa051522.37257433
17Pyruvate metabolism_Homo sapiens_hsa006202.37005960
18Adipocytokine signaling pathway_Homo sapiens_hsa049202.17241874
19beta-Alanine metabolism_Homo sapiens_hsa004102.15357197
20AMPK signaling pathway_Homo sapiens_hsa041522.12749969
21NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10963555
22Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09401313
23Legionellosis_Homo sapiens_hsa051342.06181475
24Allograft rejection_Homo sapiens_hsa053301.94783457
25Graft-versus-host disease_Homo sapiens_hsa053321.87271670
26Fat digestion and absorption_Homo sapiens_hsa049751.85158591
27B cell receptor signaling pathway_Homo sapiens_hsa046621.84801106
28Rheumatoid arthritis_Homo sapiens_hsa053231.81083571
29Hematopoietic cell lineage_Homo sapiens_hsa046401.79308353
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.78876695
31Caffeine metabolism_Homo sapiens_hsa002321.76724234
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71387476
33Phagosome_Homo sapiens_hsa041451.70682205
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69322760
35Carbon metabolism_Homo sapiens_hsa012001.67306727
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63883942
37Nitrogen metabolism_Homo sapiens_hsa009101.61424603
38Salmonella infection_Homo sapiens_hsa051321.60939293
39Staphylococcus aureus infection_Homo sapiens_hsa051501.54812800
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.51800240
41Peroxisome_Homo sapiens_hsa041461.51643707
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47910310
43Phenylalanine metabolism_Homo sapiens_hsa003601.47768884
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.45165704
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42744416
46Type I diabetes mellitus_Homo sapiens_hsa049401.35982890
47Influenza A_Homo sapiens_hsa051641.34814997
48Vitamin B6 metabolism_Homo sapiens_hsa007501.34373873
49TNF signaling pathway_Homo sapiens_hsa046681.32815049
50Chemokine signaling pathway_Homo sapiens_hsa040621.30782567
51Antigen processing and presentation_Homo sapiens_hsa046121.29929683
52Tyrosine metabolism_Homo sapiens_hsa003501.27294073
53African trypanosomiasis_Homo sapiens_hsa051431.25768981
54Insulin signaling pathway_Homo sapiens_hsa049101.22323213
55Insulin resistance_Homo sapiens_hsa049311.21898073
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21615293
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20645603
58Butanoate metabolism_Homo sapiens_hsa006501.13887433
59Shigellosis_Homo sapiens_hsa051311.13634223
60Measles_Homo sapiens_hsa051621.09466624
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08780819
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08313222
63Leukocyte transendothelial migration_Homo sapiens_hsa046701.05033766
64Pentose phosphate pathway_Homo sapiens_hsa000301.03236600
65Fatty acid elongation_Homo sapiens_hsa000621.02971867
66Herpes simplex infection_Homo sapiens_hsa051680.99581829
67T cell receptor signaling pathway_Homo sapiens_hsa046600.97869897
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.96824866
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96031953
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94069349
71Primary immunodeficiency_Homo sapiens_hsa053400.92772999
72Collecting duct acid secretion_Homo sapiens_hsa049660.91572663
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91533607
74Hepatitis B_Homo sapiens_hsa051610.91329015
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89557485
76Renin secretion_Homo sapiens_hsa049240.89328821
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86497282
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84268146
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84247113
80Glucagon signaling pathway_Homo sapiens_hsa049220.82499414
81Non-small cell lung cancer_Homo sapiens_hsa052230.81945692
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79682375
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.79232108
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77619418
85ECM-receptor interaction_Homo sapiens_hsa045120.76818686
86Pancreatic cancer_Homo sapiens_hsa052120.76287469
87Type II diabetes mellitus_Homo sapiens_hsa049300.76043530
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75134562
89VEGF signaling pathway_Homo sapiens_hsa043700.72998922
90Tryptophan metabolism_Homo sapiens_hsa003800.70631375
91Autoimmune thyroid disease_Homo sapiens_hsa053200.70609025
92Apoptosis_Homo sapiens_hsa042100.70497694
93Bladder cancer_Homo sapiens_hsa052190.70270484
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65016893
95Chronic myeloid leukemia_Homo sapiens_hsa052200.65008194
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64823351
97Protein digestion and absorption_Homo sapiens_hsa049740.64713062
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64150609
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.64107951
100Galactose metabolism_Homo sapiens_hsa000520.63579278
101Complement and coagulation cascades_Homo sapiens_hsa046100.60856346
102Renal cell carcinoma_Homo sapiens_hsa052110.60693103
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.56628120
104Endocytosis_Homo sapiens_hsa041440.55774484
105Epstein-Barr virus infection_Homo sapiens_hsa051690.55043851
106Prolactin signaling pathway_Homo sapiens_hsa049170.52174222
107ABC transporters_Homo sapiens_hsa020100.51094766
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50570044
109GnRH signaling pathway_Homo sapiens_hsa049120.48488404
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46548879
111Regulation of autophagy_Homo sapiens_hsa041400.45484405
112Arachidonic acid metabolism_Homo sapiens_hsa005900.45434791
113Biosynthesis of amino acids_Homo sapiens_hsa012300.42385217
114Focal adhesion_Homo sapiens_hsa045100.41589781
115Linoleic acid metabolism_Homo sapiens_hsa005910.41130803
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40969680
117Arginine biosynthesis_Homo sapiens_hsa002200.40864605
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39899265
119Starch and sucrose metabolism_Homo sapiens_hsa005000.39552918
120Fructose and mannose metabolism_Homo sapiens_hsa000510.39382399
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38045220
122HIF-1 signaling pathway_Homo sapiens_hsa040660.37972613
123Acute myeloid leukemia_Homo sapiens_hsa052210.37263419
124Sphingolipid metabolism_Homo sapiens_hsa006000.36067830
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35446484
126HTLV-I infection_Homo sapiens_hsa051660.34316434
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31837905
128cAMP signaling pathway_Homo sapiens_hsa040240.30056866
129Thyroid cancer_Homo sapiens_hsa052160.29136365
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28163415
131Choline metabolism in cancer_Homo sapiens_hsa052310.27544644
132Viral carcinogenesis_Homo sapiens_hsa052030.27537196
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27308895
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27024162
135Renin-angiotensin system_Homo sapiens_hsa046140.26029500
136Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25149943
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24071129
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23674025
139mTOR signaling pathway_Homo sapiens_hsa041500.23190567
140Lysosome_Homo sapiens_hsa041420.22832801
141Glutathione metabolism_Homo sapiens_hsa004800.21292761
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20612031
143Sulfur metabolism_Homo sapiens_hsa009200.19092806
144Lysine degradation_Homo sapiens_hsa003100.18979476
145Metabolic pathways_Homo sapiens_hsa011000.17909274
146Primary bile acid biosynthesis_Homo sapiens_hsa001200.17865060
147Proteoglycans in cancer_Homo sapiens_hsa052050.17829636
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.17574880
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17292141
150Chemical carcinogenesis_Homo sapiens_hsa052040.17260313
151Melanoma_Homo sapiens_hsa052180.15359190
152Amoebiasis_Homo sapiens_hsa051460.13523635
153Salivary secretion_Homo sapiens_hsa049700.13483963
154Toxoplasmosis_Homo sapiens_hsa051450.13403393
155Jak-STAT signaling pathway_Homo sapiens_hsa046300.12508402
156Small cell lung cancer_Homo sapiens_hsa052220.12236063
157Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11123656
158Sphingolipid signaling pathway_Homo sapiens_hsa040710.10931289
159Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08653296
160Pertussis_Homo sapiens_hsa051330.07494524
161Hepatitis C_Homo sapiens_hsa051600.07291360
162Sulfur relay system_Homo sapiens_hsa041220.07066762
163Thyroid hormone synthesis_Homo sapiens_hsa049180.04999951
164Viral myocarditis_Homo sapiens_hsa054160.03582883
165Vascular smooth muscle contraction_Homo sapiens_hsa042700.03182237
166Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.02383419
167Platelet activation_Homo sapiens_hsa046110.02292393
168FoxO signaling pathway_Homo sapiens_hsa040680.01968252
169Prion diseases_Homo sapiens_hsa050200.01717424
170Ovarian steroidogenesis_Homo sapiens_hsa049130.01680597
171Malaria_Homo sapiens_hsa051440.00194711
172Phospholipase D signaling pathway_Homo sapiens_hsa040720.00161026

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