RETSAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.10212537
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.10212537
3L-phenylalanine metabolic process (GO:0006558)6.87016292
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.87016292
5low-density lipoprotein particle clearance (GO:0034383)6.57064071
6aromatic amino acid family catabolic process (GO:0009074)6.42856328
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.20485314
8alpha-linolenic acid metabolic process (GO:0036109)5.92805050
9indole-containing compound catabolic process (GO:0042436)5.82067648
10indolalkylamine catabolic process (GO:0046218)5.82067648
11tryptophan catabolic process (GO:0006569)5.82067648
12kynurenine metabolic process (GO:0070189)5.75570661
13glyoxylate metabolic process (GO:0046487)5.68296555
14bile acid biosynthetic process (GO:0006699)5.66432378
15tryptophan metabolic process (GO:0006568)5.49208215
16triglyceride catabolic process (GO:0019433)5.45723354
17sulfur amino acid catabolic process (GO:0000098)5.39380638
18cysteine metabolic process (GO:0006534)5.33326199
19NADH metabolic process (GO:0006734)5.31886250
20urea cycle (GO:0000050)5.22716962
21urea metabolic process (GO:0019627)5.22716962
22high-density lipoprotein particle remodeling (GO:0034375)5.21820204
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.21197086
24lysine metabolic process (GO:0006553)5.03818068
25lysine catabolic process (GO:0006554)5.03818068
26acylglycerol catabolic process (GO:0046464)5.02340530
27neutral lipid catabolic process (GO:0046461)5.02340530
28serine family amino acid catabolic process (GO:0009071)5.00536895
29negative regulation of fibrinolysis (GO:0051918)4.99484638
30protein carboxylation (GO:0018214)4.89995487
31peptidyl-glutamic acid carboxylation (GO:0017187)4.89995487
32regulation of triglyceride catabolic process (GO:0010896)4.88754439
33amino-acid betaine metabolic process (GO:0006577)4.85432625
34bile acid metabolic process (GO:0008206)4.85422244
35diacylglycerol metabolic process (GO:0046339)4.83521964
36nitrogen cycle metabolic process (GO:0071941)4.82178547
37complement activation, alternative pathway (GO:0006957)4.76725892
38regulation of fibrinolysis (GO:0051917)4.76276892
39homocysteine metabolic process (GO:0050667)4.74442937
40cellular ketone body metabolic process (GO:0046950)4.70032158
41aromatic amino acid family metabolic process (GO:0009072)4.69406894
42regulation of cholesterol esterification (GO:0010872)4.68592547
43regulation of protein activation cascade (GO:2000257)4.66068100
44reverse cholesterol transport (GO:0043691)4.62017445
45regulation of sequestering of triglyceride (GO:0010889)4.61071249
46plasma lipoprotein particle remodeling (GO:0034369)4.56368931
47protein-lipid complex remodeling (GO:0034368)4.56368931
48macromolecular complex remodeling (GO:0034367)4.56368931
49alpha-amino acid catabolic process (GO:1901606)4.53593243
50tyrosine metabolic process (GO:0006570)4.48080058
51negative regulation of cholesterol transport (GO:0032375)4.47804382
52negative regulation of sterol transport (GO:0032372)4.47804382
53acylglycerol homeostasis (GO:0055090)4.47635880
54triglyceride homeostasis (GO:0070328)4.47635880
55fatty acid homeostasis (GO:0055089)4.39263540
56phospholipid efflux (GO:0033700)4.36586477
57regulation of complement activation (GO:0030449)4.35866334
58plasma lipoprotein particle clearance (GO:0034381)4.32458995
59cellular amino acid catabolic process (GO:0009063)4.24719474
60glycine metabolic process (GO:0006544)4.22334583
61coenzyme catabolic process (GO:0009109)4.19329318
62ethanol oxidation (GO:0006069)4.16041535
63angiotensin maturation (GO:0002003)4.15637941
64serine family amino acid metabolic process (GO:0009069)4.14539214
65indolalkylamine metabolic process (GO:0006586)4.10084664
66glutamate metabolic process (GO:0006536)4.09542099
67regulation of cholesterol storage (GO:0010885)4.08930645
68lipoprotein transport (GO:0042953)4.08551856
69ketone body metabolic process (GO:1902224)4.08279401
70cellular glucuronidation (GO:0052695)4.07804694
71bile acid and bile salt transport (GO:0015721)4.07536463
72short-chain fatty acid metabolic process (GO:0046459)4.07353478
73cellular modified amino acid catabolic process (GO:0042219)4.06930949
74cellular biogenic amine catabolic process (GO:0042402)4.01909618
75amine catabolic process (GO:0009310)4.01909618
76fatty acid beta-oxidation (GO:0006635)3.99859363
77acetyl-CoA metabolic process (GO:0006084)3.96408372
78benzene-containing compound metabolic process (GO:0042537)3.94664796
79serine family amino acid biosynthetic process (GO:0009070)3.94345368
80imidazole-containing compound metabolic process (GO:0052803)3.94184812
81cholesterol efflux (GO:0033344)3.94125523
82intestinal absorption (GO:0050892)3.94057640
83fatty acid oxidation (GO:0019395)3.90244375
84drug catabolic process (GO:0042737)3.89949714
85regulation of plasminogen activation (GO:0010755)3.88130539
86carboxylic acid catabolic process (GO:0046395)3.87653870
87organic acid catabolic process (GO:0016054)3.87653870
88low-density lipoprotein particle remodeling (GO:0034374)3.86294010
89triglyceride biosynthetic process (GO:0019432)3.86191175
90positive regulation of lipid catabolic process (GO:0050996)3.85396912
91ethanol metabolic process (GO:0006067)3.85252340
92lipid oxidation (GO:0034440)3.83745831
93plasma lipoprotein particle assembly (GO:0034377)3.83634898
94dicarboxylic acid biosynthetic process (GO:0043650)3.83585936
95carnitine metabolic process (GO:0009437)3.82437133
96monocarboxylic acid catabolic process (GO:0072329)3.78270812
97aldehyde catabolic process (GO:0046185)3.77437553
98fatty acid catabolic process (GO:0009062)3.77172406
99positive regulation of triglyceride lipase activity (GO:0061365)3.74838682
100positive regulation of lipoprotein lipase activity (GO:0051006)3.74838682
101phospholipid homeostasis (GO:0055091)3.74135792
102arginine metabolic process (GO:0006525)3.73909747
1032-oxoglutarate metabolic process (GO:0006103)3.73116162
104aspartate family amino acid catabolic process (GO:0009068)3.71878064
105positive regulation of fatty acid beta-oxidation (GO:0032000)3.71797830
106acylglycerol biosynthetic process (GO:0046463)3.70510934
107neutral lipid biosynthetic process (GO:0046460)3.70510934
108cholesterol homeostasis (GO:0042632)3.66020152
109negative regulation of lipase activity (GO:0060192)3.65743703
110regulation of cholesterol homeostasis (GO:2000188)3.65114392
111glucuronate metabolic process (GO:0019585)3.63887625
112uronic acid metabolic process (GO:0006063)3.63887625
113drug transmembrane transport (GO:0006855)3.63655142
114fibrinolysis (GO:0042730)3.63253120
115sterol homeostasis (GO:0055092)3.60882213
116cofactor catabolic process (GO:0051187)3.58801302
117very-low-density lipoprotein particle assembly (GO:0034379)3.58694300
118regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.55222901
119triglyceride metabolic process (GO:0006641)3.52519216
120oxaloacetate metabolic process (GO:0006107)3.50901413
121glycerolipid catabolic process (GO:0046503)3.50761193
122tricarboxylic acid metabolic process (GO:0072350)3.46770765
123white fat cell differentiation (GO:0050872)3.45293006
124epoxygenase P450 pathway (GO:0019373)3.38313119
125desmosome organization (GO:0002934)3.32430848
126acylglycerol metabolic process (GO:0006639)3.30443097
127positive regulation of fatty acid metabolic process (GO:0045923)3.25975959
128neutral lipid metabolic process (GO:0006638)3.24840094
129transcytosis (GO:0045056)3.24661199
130biotin metabolic process (GO:0006768)3.15134139
131lipid storage (GO:0019915)3.08033115
132primary alcohol catabolic process (GO:0034310)3.05907521
133regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.04058059
134aminoglycoside antibiotic metabolic process (GO:0030647)3.03085805
135fat-soluble vitamin biosynthetic process (GO:0042362)3.00172485
136polyketide metabolic process (GO:0030638)2.91856800
137doxorubicin metabolic process (GO:0044598)2.91856800
138daunorubicin metabolic process (GO:0044597)2.91856800
139cGMP-mediated signaling (GO:0019934)2.90687185
140fatty acid transmembrane transport (GO:1902001)2.88897329
141* primary alcohol metabolic process (GO:0034308)2.85888670
142long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.84881578
143fatty-acyl-CoA metabolic process (GO:0035337)2.84614948
144very long-chain fatty acid metabolic process (GO:0000038)2.84613983
145negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.84371391
146regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.83775484
147thioester biosynthetic process (GO:0035384)2.82621160
148acyl-CoA biosynthetic process (GO:0071616)2.82621160
149regulation of sterol transport (GO:0032371)2.82239467
150regulation of cholesterol transport (GO:0032374)2.82239467
151regulation of cholesterol metabolic process (GO:0090181)2.82140160
152fatty-acyl-CoA biosynthetic process (GO:0046949)2.81771313
153carnitine shuttle (GO:0006853)2.79387689
154lipoprotein metabolic process (GO:0042157)2.78186433
155positive regulation of cholesterol efflux (GO:0010875)2.77576254
156negative regulation of fatty acid transport (GO:2000192)2.77518307
157regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.77449293
158fructose metabolic process (GO:0006000)2.76519678
159positive regulation of lipid storage (GO:0010884)2.76424179
160glycerol metabolic process (GO:0006071)2.75584595
161brown fat cell differentiation (GO:0050873)2.74023670
162positive regulation of fatty acid biosynthetic process (GO:0045723)2.72701168
163positive regulation of fatty acid oxidation (GO:0046321)2.71506083
164regulation of macrophage derived foam cell differentiation (GO:0010743)2.69296887
165linoleic acid metabolic process (GO:0043651)2.67748228
166acyl-CoA metabolic process (GO:0006637)2.67219221
167thioester metabolic process (GO:0035383)2.67219221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.21136239
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11845309
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.54663684
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.37549969
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.08869787
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.97810920
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81343524
8TP63_17297297_ChIP-ChIP_HaCaT_Human4.52961218
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.89046853
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77146267
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.76374031
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66575505
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.18701556
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05258067
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5423928
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.91699088
17CLOCK_20551151_ChIP-Seq_293T_Human1.84355628
18ELK3_25401928_ChIP-Seq_HUVEC_Human1.69149295
19KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60056512
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56908418
21FOXA2_19822575_ChIP-Seq_HepG2_Human1.54923397
22GATA1_22025678_ChIP-Seq_K562_Human1.45433856
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44201714
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42891857
25HNF4A_19822575_ChIP-Seq_HepG2_Human1.41605855
26P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40610833
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39022511
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37158970
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.33901798
30HTT_18923047_ChIP-ChIP_STHdh_Human1.30582157
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28394112
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22340936
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20522967
34UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20138192
35TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19936314
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18965616
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15465446
38RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15317429
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13961827
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12801404
41ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10935950
42P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10483585
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09839064
44SOX9_24532713_ChIP-Seq_HFSC_Mouse1.08285393
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07010639
46* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06760476
47KDM2B_26808549_Chip-Seq_K562_Human1.06297596
48SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04519404
49PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04382649
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.02712105
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02495788
52HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02042143
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.01035456
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.00153783
55ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00099954
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99361219
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98847146
58ATF3_27146783_Chip-Seq_COLON_Human0.96988107
59NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96413672
60ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95494414
61SMC4_20622854_ChIP-Seq_HELA_Human0.94838917
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94720537
63CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94313980
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92861443
65* GATA4_25053715_ChIP-Seq_YYC3_Human0.92680527
66P68_20966046_ChIP-Seq_HELA_Human0.91900100
67RUNX1_27514584_Chip-Seq_MCF-7_Human0.91769840
68SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.90828345
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.90828345
70TP53_22127205_ChIP-Seq_IMR90_Human0.90727042
71TCF7_22412390_ChIP-Seq_EML_Mouse0.90324490
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89643850
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89433928
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89346714
75UBF1/2_26484160_Chip-Seq_HMECs_Human0.88943998
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88150561
77ZNF263_19887448_ChIP-Seq_K562_Human0.87998683
78VDR_21846776_ChIP-Seq_THP-1_Human0.87577743
79CTCF_27219007_Chip-Seq_Bcells_Human0.87488475
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86861353
81* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86781082
82TP63_22573176_ChIP-Seq_HFKS_Human0.85894510
83CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85824322
84SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.84477738
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83690785
86ESR2_21235772_ChIP-Seq_MCF-7_Human0.81377906
87* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79717399
88IRF8_22096565_ChIP-ChIP_GC-B_Human0.77492416
89AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77369351
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77067895
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75920215
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75299694
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71879395
94SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71740829
95PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.71374719
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.71150369
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70997379
98* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70916477
99KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67131865
100RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66908290
101LXR_22292898_ChIP-Seq_THP-1_Human0.66634187
102BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65645283
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62788234
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62788234
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.62174898
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.61152527
107* CEBPB_22108803_ChIP-Seq_LS180_Human0.60918055
108RARB_24833708_ChIP-Seq_LIVER_Mouse0.60648349
109* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60631516
110EGR1_19032775_ChIP-ChIP_M12_Human0.55759420
111* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.54822031
112AR_20517297_ChIP-Seq_VCAP_Human0.54548962
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.53809324
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52589591
115ESET_19884257_ChIP-Seq_ESCs_Mouse0.50451846
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50221571
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.50162738
118* GATA6_25053715_ChIP-Seq_YYC3_Human0.49114062
119FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48448412
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.48053376
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47080667
122GATA2_19941826_ChIP-Seq_K562_Human0.47069564
123MYC_19915707_ChIP-ChIP_AK7_Human0.46691511
124GATA1_19941826_ChIP-Seq_K562_Human0.46633612
125CBP_21632823_ChIP-Seq_H3396_Human0.46213654
126GATA1_19941827_ChIP-Seq_MEL_Mouse0.45365729
127TAF2_19829295_ChIP-Seq_ESCs_Human0.44887105
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.44863430
129ESR1_20079471_ChIP-ChIP_T-47D_Human0.44283877
130TBX20_22080862_ChIP-Seq_HEART_Mouse0.43834365
131TBX20_22328084_ChIP-Seq_HEART_Mouse0.43834365
132RACK7_27058665_Chip-Seq_MCF-7_Human0.43528955
133P53_21459846_ChIP-Seq_SAOS-2_Human0.43434749
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42827476
135STAT1_17558387_ChIP-Seq_HELA_Human0.42244642
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42105469
137SOX2_20726797_ChIP-Seq_SW620_Human0.42035184
138GATA3_24758297_ChIP-Seq_MCF-7_Human0.41409546
139CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.41065416
140SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41024150
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.39761196
142BCOR_27268052_Chip-Seq_Bcells_Human0.38959626
143CSB_26484114_Chip-Seq_FIBROBLAST_Human0.38230246
144STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38094323
145ERG_20517297_ChIP-Seq_VCAP_Human0.37936545
146* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.36195640
147TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.36145341
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.35777037

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.11849048
2MP0005360_urolithiasis7.37392629
3MP0005085_abnormal_gallbladder_physiolo6.08698371
4MP0005365_abnormal_bile_salt6.04632437
5MP0008875_abnormal_xenobiotic_pharmacok4.90454025
6MP0003806_abnormal_nucleotide_metabolis4.18713389
7MP0003252_abnormal_bile_duct3.81196635
8MP0010329_abnormal_lipoprotein_level3.55569537
9MP0009840_abnormal_foam_cell3.32419990
10MP0005332_abnormal_amino_acid2.95575766
11MP0005083_abnormal_biliary_tract2.87565056
12MP0003195_calcinosis2.79082076
13MP0001666_abnormal_nutrient_absorption2.56270514
14MP0003191_abnormal_cellular_cholesterol2.41351292
15MP0004019_abnormal_vitamin_homeostasis2.24843608
16MP0002118_abnormal_lipid_homeostasis2.17891593
17MP0008438_abnormal_cutaneous_collagen2.17361784
18MP0000609_abnormal_liver_physiology2.14270376
19MP0010234_abnormal_vibrissa_follicle1.95940461
20MP0002138_abnormal_hepatobiliary_system1.92752489
21MP0000003_abnormal_adipose_tissue1.91139129
22MP0003183_abnormal_peptide_metabolism1.89316819
23MP0005319_abnormal_enzyme/_coenzyme1.88120882
24MP0003868_abnormal_feces_composition1.70808408
25MP0005451_abnormal_body_composition1.69704174
26MP0005409_darkened_coat_color1.69272154
27MP0001764_abnormal_homeostasis1.66981740
28MP0000013_abnormal_adipose_tissue1.65069829
29MP0005584_abnormal_enzyme/coenzyme_acti1.64053796
30MP0005275_abnormal_skin_tensile1.57481071
31MP0006138_congestive_heart_failure1.48215507
32MP0004272_abnormal_basement_membrane1.48164876
33MP0009643_abnormal_urine_homeostasis1.48006830
34MP0003186_abnormal_redox_activity1.47573709
35MP0003959_abnormal_lean_body1.43050935
36MP0009697_abnormal_copulation1.34153931
37MP0003011_delayed_dark_adaptation1.33206767
38MP0005670_abnormal_white_adipose1.32548352
39MP0003705_abnormal_hypodermis_morpholog1.27066488
40MP0003566_abnormal_cell_adhesion1.26509531
41MP0000751_myopathy1.18672354
42MP0003656_abnormal_erythrocyte_physiolo1.17309249
43MP0000598_abnormal_liver_morphology1.14533889
44MP0009780_abnormal_chondrocyte_physiolo1.11938195
45MP0004130_abnormal_muscle_cell1.07377070
46MP0005647_abnormal_sex_gland1.07336533
47MP0004858_abnormal_nervous_system1.05817451
48MP0006036_abnormal_mitochondrial_physio1.05424513
49MP0003828_pulmonary_edema1.05131369
50MP0009764_decreased_sensitivity_to1.04421231
51MP0005636_abnormal_mineral_homeostasis1.02115853
52MP0000604_amyloidosis1.00981313
53MP0000858_altered_metastatic_potential0.99679534
54MP0002254_reproductive_system_inflammat0.99093676
55MP0009763_increased_sensitivity_to0.95555732
56MP0003879_abnormal_hair_cell0.93433207
57MP0009379_abnormal_foot_pigmentation0.92874337
58MP0002971_abnormal_brown_adipose0.92448657
59MP0004264_abnormal_extraembryonic_tissu0.92281005
60MP0005257_abnormal_intraocular_pressure0.91471889
61MP0003453_abnormal_keratinocyte_physiol0.88332175
62MP0001756_abnormal_urination0.87562894
63MP0009642_abnormal_blood_homeostasis0.86874901
64MP0008469_abnormal_protein_level0.86192620
65MP0005023_abnormal_wound_healing0.85417779
66MP0002060_abnormal_skin_morphology0.85157717
67MP0005376_homeostasis/metabolism_phenot0.83528592
68MP0002078_abnormal_glucose_homeostasis0.83457626
69MP0005666_abnormal_adipose_tissue0.83205070
70MP0003279_aneurysm0.83172928
71MP0005452_abnormal_adipose_tissue0.82737488
72MP0002876_abnormal_thyroid_physiology0.82559080
73MP0002896_abnormal_bone_mineralization0.81885173
74MP0001958_emphysema0.81531640
75MP0010368_abnormal_lymphatic_system0.81114724
76MP0003300_gastrointestinal_ulcer0.80686369
77MP0005334_abnormal_fat_pad0.80618199
78MP0005503_abnormal_tendon_morphology0.79625470
79MP0001849_ear_inflammation0.78950155
80MP0005501_abnormal_skin_physiology0.77030560
81MP0005535_abnormal_body_temperature0.76745967
82MP0003091_abnormal_cell_migration0.74781494
83MP0005266_abnormal_metabolism0.73877972
84MP0005165_increased_susceptibility_to0.73412745
85MP0003690_abnormal_glial_cell0.72986850
86MP0002837_dystrophic_cardiac_calcinosis0.72543592
87MP0003950_abnormal_plasma_membrane0.72449877
88MP0005408_hypopigmentation0.72414441
89MP0001661_extended_life_span0.72304805
90MP0005595_abnormal_vascular_smooth0.72274964
91MP0005084_abnormal_gallbladder_morpholo0.72091857
92MP0009765_abnormal_xenobiotic_induced0.70235985
93MP0006035_abnormal_mitochondrial_morpho0.68812867
94MP0000343_altered_response_to0.67091469
95MP0002136_abnormal_kidney_physiology0.66329060
96MP0010352_gastrointestinal_tract_polyps0.65959563
97MP0000467_abnormal_esophagus_morphology0.65754843
98MP0010155_abnormal_intestine_physiology0.65218638
99MP0001533_abnormal_skeleton_physiology0.65080651
100MP0004043_abnormal_pH_regulation0.64569702
101MP0001216_abnormal_epidermal_layer0.63969569
102MP0002877_abnormal_melanocyte_morpholog0.63917608
103MP0005076_abnormal_cell_differentiation0.62915356
104MP0003329_amyloid_beta_deposits0.60742451
105MP0002933_joint_inflammation0.60289380
106MP0005448_abnormal_energy_balance0.59990204
107MP0002909_abnormal_adrenal_gland0.59852812
108MP0005220_abnormal_exocrine_pancreas0.58816122
109MP0004947_skin_inflammation0.58634242
110MP0009115_abnormal_fat_cell0.53367993
111MP0009053_abnormal_anal_canal0.53261176
112MP0003724_increased_susceptibility_to0.50172234
113MP0005395_other_phenotype0.47601662
114MP0000230_abnormal_systemic_arterial0.47571237
115MP0000639_abnormal_adrenal_gland0.46887054
116MP0003638_abnormal_response/metabolism_0.45914868
117MP0005058_abnormal_lysosome_morphology0.45665415
118MP0003953_abnormal_hormone_level0.43828366
119MP0002970_abnormal_white_adipose0.43731355
120MP0004782_abnormal_surfactant_physiolog0.43371870
121MP0001853_heart_inflammation0.43241271
122MP0005464_abnormal_platelet_physiology0.43186920
123MP0002796_impaired_skin_barrier0.42180949
124MP0003075_altered_response_to0.42022770
125MP0002928_abnormal_bile_duct0.41180053
126MP0008874_decreased_physiological_sensi0.40549980
127MP0008873_increased_physiological_sensi0.39932531
128MP0002168_other_aberrant_phenotype0.39088953
129MP0004185_abnormal_adipocyte_glucose0.39065256
130MP0003718_maternal_effect0.36500240
131MP0001765_abnormal_ion_homeostasis0.36281263
132MP0009384_cardiac_valve_regurgitation0.36092012
133MP0005166_decreased_susceptibility_to0.35940268
134MP0009672_abnormal_birth_weight0.35504696
135MP0000249_abnormal_blood_vessel0.35294423
136MP0003436_decreased_susceptibility_to0.35010997
137MP0005375_adipose_tissue_phenotype0.33226990
138MP0008872_abnormal_physiological_respon0.32570012
139MP0005330_cardiomyopathy0.31274162
140MP0001881_abnormal_mammary_gland0.30824797
141MP0005248_abnormal_Harderian_gland0.30192048
142MP0001243_abnormal_dermal_layer0.29747912
143MP0004883_abnormal_blood_vessel0.29203617
144MP0002269_muscular_atrophy0.28478407
145MP0002822_catalepsy0.28316819
146MP0005164_abnormal_response_to0.28287595

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.79888826
2Intrahepatic cholestasis (HP:0001406)6.70296847
3Deep venous thrombosis (HP:0002625)6.60877638
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.13659243
5Xanthomatosis (HP:0000991)6.12156754
6Hypobetalipoproteinemia (HP:0003563)5.93481402
7Prolonged partial thromboplastin time (HP:0003645)5.71225328
8Hyperlipoproteinemia (HP:0010980)5.32180654
9Hyperammonemia (HP:0001987)4.82970383
10Complement deficiency (HP:0004431)4.66001902
11Hypolipoproteinemia (HP:0010981)4.61639637
12Hyperglycinuria (HP:0003108)4.60742744
13Hyperglycinemia (HP:0002154)4.57085789
14Ketosis (HP:0001946)4.54289245
15Abnormality of serine family amino acid metabolism (HP:0010894)4.42446374
16Abnormality of glycine metabolism (HP:0010895)4.42446374
17Epidermoid cyst (HP:0200040)4.29512806
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.26510028
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24402596
20Joint hemorrhage (HP:0005261)4.23587603
21Hypoglycemic coma (HP:0001325)4.20046651
22Hypoalphalipoproteinemia (HP:0003233)4.19203437
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17106692
24Abnormality of sulfur amino acid metabolism (HP:0004339)4.15958502
25Abnormality of methionine metabolism (HP:0010901)4.02928656
26Abnormality of fatty-acid metabolism (HP:0004359)4.00853883
27Abnormality of the common coagulation pathway (HP:0010990)3.85229932
28Fat malabsorption (HP:0002630)3.81325006
29Protrusio acetabuli (HP:0003179)3.65185545
30Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.64909873
31Acanthosis nigricans (HP:0000956)3.55155035
32Ketoacidosis (HP:0001993)3.53734640
33Abnormality of pyrimidine metabolism (HP:0004353)3.53283042
34Hypercholesterolemia (HP:0003124)3.46929521
35Abnormality of complement system (HP:0005339)3.39350210
36Abnormality of the intrinsic pathway (HP:0010989)3.37570131
37Oligomenorrhea (HP:0000876)3.36159337
38Conjugated hyperbilirubinemia (HP:0002908)3.29196773
39Dicarboxylic aciduria (HP:0003215)3.20053836
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.20053836
41Ileus (HP:0002595)3.19823275
42Abnormality of serum amino acid levels (HP:0003112)3.17872614
43Hyperbilirubinemia (HP:0002904)3.17822214
44Abnormality of nucleobase metabolism (HP:0010932)3.17655520
45Delayed CNS myelination (HP:0002188)3.17446247
46Metabolic acidosis (HP:0001942)3.03401631
47Abnormality of purine metabolism (HP:0004352)2.99841759
48Vertebral compression fractures (HP:0002953)2.99664537
49Gout (HP:0001997)2.86835816
50Steatorrhea (HP:0002570)2.86098500
51Lethargy (HP:0001254)2.83374565
52Myocardial infarction (HP:0001658)2.80559396
53Hepatocellular carcinoma (HP:0001402)2.80115503
54Pigmentary retinal degeneration (HP:0001146)2.71481697
55Skin nodule (HP:0200036)2.71395243
56Generalized aminoaciduria (HP:0002909)2.61782133
57Flat acetabular roof (HP:0003180)2.61252446
58Vascular calcification (HP:0004934)2.57055310
59Abnormality of carpal bone ossification (HP:0006257)2.55331247
60Cerebral edema (HP:0002181)2.55188111
61Hypochromic microcytic anemia (HP:0004840)2.46871277
62Premature rupture of membranes (HP:0001788)2.46601352
63Malnutrition (HP:0004395)2.45725730
64Insulin resistance (HP:0000855)2.44226298
65Increased variability in muscle fiber diameter (HP:0003557)2.43993615
66Spastic diplegia (HP:0001264)2.43299850
67Back pain (HP:0003418)2.43247715
68Systemic lupus erythematosus (HP:0002725)2.43116922
69Spontaneous abortion (HP:0005268)2.40065224
70Proximal tubulopathy (HP:0000114)2.39036919
71Hypoglycemic seizures (HP:0002173)2.37764426
72Vomiting (HP:0002013)2.37274476
73Abnormal gallbladder morphology (HP:0012437)2.35323329
74Cholelithiasis (HP:0001081)2.33321235
75Irritability (HP:0000737)2.32829337
76Cholecystitis (HP:0001082)2.31077547
77Abnormal gallbladder physiology (HP:0012438)2.31077547
78Cardiovascular calcification (HP:0011915)2.29251756
79Acanthocytosis (HP:0001927)2.27145783
80Pancreatitis (HP:0001733)2.27069788
81Neonatal onset (HP:0003623)2.26884720
82Growth hormone excess (HP:0000845)2.26534103
83Thin bony cortex (HP:0002753)2.23119180
84Hydroxyprolinuria (HP:0003080)2.22645848
85Abnormality of proline metabolism (HP:0010907)2.22645848
86Sensorimotor neuropathy (HP:0007141)2.21441545
87Brushfield spots (HP:0001088)2.19096625
88Axonal loss (HP:0003447)2.17001038
89Nephritis (HP:0000123)2.16424711
90Late onset (HP:0003584)2.15970155
91Increased connective tissue (HP:0009025)2.15209646
92Renal cortical cysts (HP:0000803)2.14064717
93Increased purine levels (HP:0004368)2.13161231
94Hyperuricemia (HP:0002149)2.13161231
95Mitral stenosis (HP:0001718)2.12998988
96Alkalosis (HP:0001948)2.12306310
97Enlarged kidneys (HP:0000105)2.11785932
98Esophageal varix (HP:0002040)2.10838340
99Amyloidosis (HP:0011034)2.10089118
100Nausea (HP:0002018)2.08842688
101Abnormal ossification of hand bones (HP:0005921)2.08780866
102Rhabdomyolysis (HP:0003201)2.08147259
103Abnormality of skeletal muscle fiber size (HP:0012084)2.07921937
104Reduced subcutaneous adipose tissue (HP:0003758)2.07755903
105Glycosuria (HP:0003076)2.07576686
106Abnormality of urine glucose concentration (HP:0011016)2.07576686
107Abnormal tarsal ossification (HP:0008369)2.06191728
108Glomerulonephritis (HP:0000099)2.06054337
109Abnormal cartilage morphology (HP:0002763)2.05622959
110Cerebral aneurysm (HP:0004944)2.04239897
111Rickets (HP:0002748)2.03525076
112Opisthotonus (HP:0002179)2.02591714
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02373279
114Abnormality of alanine metabolism (HP:0010916)2.02373279
115Hyperalaninemia (HP:0003348)2.02373279
116Hyperinsulinemic hypoglycemia (HP:0000825)2.01970589
117Vascular tortuosity (HP:0004948)2.00509809
118Widely patent fontanelles and sutures (HP:0004492)2.00207084
119Cervical subluxation (HP:0003308)1.99656673
120Polycythemia (HP:0001901)1.98127018
121Polygenic inheritance (HP:0010982)1.96260308
122Visceral angiomatosis (HP:0100761)1.95040146
123Spontaneous hematomas (HP:0007420)1.94922825
124Hyperparathyroidism (HP:0000843)1.94094842
125Focal segmental glomerulosclerosis (HP:0000097)1.92892525
126Insulin-resistant diabetes mellitus (HP:0000831)1.92631685
127Recurrent gram-negative bacterial infections (HP:0005420)1.92541438
128Hemorrhage of the eye (HP:0011885)1.92265193
129Right ventricular cardiomyopathy (HP:0011663)1.91814051
130Abnormality of the gallbladder (HP:0005264)1.91128110
131Hypertriglyceridemia (HP:0002155)1.91065929
132Arterial tortuosity (HP:0005116)1.90504094
133Aortic aneurysm (HP:0004942)1.88880411
134Menorrhagia (HP:0000132)1.88219983
135Elevated hepatic transaminases (HP:0002910)1.85735426
136Wide cranial sutures (HP:0010537)1.85083690
137Thrombophlebitis (HP:0004418)1.83801449
138Abnormal hand bone ossification (HP:0010660)1.83521374
139Hypophosphatemia (HP:0002148)1.83516247
140Gingival bleeding (HP:0000225)1.83371233
141Hemangiomatosis (HP:0007461)1.82912582
142Increased serum pyruvate (HP:0003542)1.82794578
143Abnormality of vitamin metabolism (HP:0100508)1.82720095
144Abnormal enzyme/coenzyme activity (HP:0012379)1.82309769
145Wormian bones (HP:0002645)1.80221592
146Mildly elevated creatine phosphokinase (HP:0008180)1.78373189
147Hypercortisolism (HP:0001578)1.77968907
148Exercise-induced myalgia (HP:0003738)1.77410974
149Multiple lipomas (HP:0001012)1.77027199
150Subcapsular cataract (HP:0000523)1.76938700
151Gastrointestinal dysmotility (HP:0002579)1.76499544
152Biconcave vertebral bodies (HP:0004586)1.75092579
153Spinal rigidity (HP:0003306)1.72778507
154Osteolytic defects of the phalanges of the hand (HP:0009771)1.72222395
155Osteolytic defects of the hand bones (HP:0009699)1.72222395
156Abnormal glucose tolerance (HP:0001952)1.72199027
157Stroke (HP:0001297)1.71416554
158Aneurysm (HP:0002617)1.71102343
159Glomerulosclerosis (HP:0000096)1.70240303
160Cerebral inclusion bodies (HP:0100314)1.69637572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.57894043
2ERN14.45757748
3SIK14.38928045
4FGFR43.81463501
5EPHB22.63785781
6EPHA22.56831548
7PKN22.56290589
8INSRR2.54235007
9TRIB32.45069253
10TAOK32.37632693
11MST1R2.33786478
12ERBB42.15744914
13DDR22.07420579
14PRPF4B2.00115274
15FLT31.98797674
16PIK3CG1.80261944
17MAP2K41.78014496
18EEF2K1.76060942
19TESK11.70102670
20MAPK111.69704051
21ACVR1B1.48279624
22TYK21.47729643
23NEK91.46406718
24ABL21.44172890
25SMG11.38381139
26PTK61.38230935
27LATS11.37220992
28PRKAA21.34260529
29FRK1.33797742
30PAK41.31688790
31PDK31.31683009
32PDK41.31683009
33MAP2K31.30857943
34LATS21.30095139
35KDR1.28744227
36MAP3K71.24106590
37PINK11.23428588
38CAMK1D1.21940399
39PRKG21.14777778
40FGFR21.13136034
41TIE11.12090126
42STK38L1.10988850
43JAK31.10896849
44TTN1.06812407
45JAK21.06116100
46CDK91.04640649
47MAP3K31.04605490
48TBK11.01062565
49GRK60.99083908
50MET0.97179647
51IRAK30.95927357
52MAP3K10.94600976
53CDC42BPA0.94121604
54KSR20.93404782
55NTRK10.91679851
56MAP3K20.90691718
57MAPK40.90410307
58WNK30.89324475
59DAPK20.89006609
60JAK10.88326406
61MAP3K110.87882672
62MAPK120.87773366
63RIPK10.87157755
64MAPKAPK30.85525793
65PDK20.84517829
66TGFBR20.82192091
67MAP3K100.80754959
68PRKAA10.80501990
69CDK60.80064079
70EPHB10.79719697
71PIM20.79003247
72WNK40.78271031
73ARAF0.75321002
74PRKACG0.74859650
75ERBB20.74699874
76PRKCZ0.73014901
77GSK3A0.72443705
78MAP3K130.70592170
79PDGFRB0.69462097
80MAPK150.67462920
81MAP3K140.67238802
82ZAP700.66720413
83OXSR10.65721985
84CSK0.64773100
85MAP2K60.64679391
86FER0.64398705
87SGK30.63497991
88DYRK1B0.60970635
89PDPK10.60338816
90CAMK10.58240484
91AKT30.56609131
92CSF1R0.55994244
93TAOK20.55804072
94NEK10.54891451
95STK380.54626592
96PRKD20.53931677
97MYLK0.53166945
98TRPM70.52529507
99MAPK70.50647174
100CAMK2G0.50619711
101CAMK1G0.49191106
102RIPK40.48582753
103FGR0.48515974
104PTK20.45509766
105PIK3CA0.45451205
106IGF1R0.45096309
107PAK20.44939344
108MAP3K50.44854535
109CDK40.43669050
110RPS6KA20.42491799
111SCYL20.41489389
112TYRO30.41268526
113SRC0.40779898
114OBSCN0.40669861
115PRKCQ0.40583589
116MAP2K10.40234827
117FGFR30.40023310
118RPS6KB20.39889023
119SGK20.39859647
120PRKD10.38884089
121CDK120.38461377
122GRK10.38094961
123PDK10.37915327
124MTOR0.37891340
125MARK20.37769526
126IKBKE0.37262175
127EPHA30.37002701
128SGK2230.36790566
129SGK4940.36790566
130MAP3K60.36656842
131PBK0.36113078
132LMTK20.36087865
133YES10.35185203
134PRKD30.34787740
135MOS0.34272181
136AKT20.33733225
137BMX0.29559798
138CAMK40.26542704
139RET0.24988349
140MAP2K20.24361559
141EGFR0.23409181
142PRKCA0.22563278
143ICK0.21789963
144CSNK1G10.20746739
145PDGFRA0.20415029
146ABL10.20069436

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.14953897
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.26223886
3Nitrogen metabolism_Homo sapiens_hsa009103.21771482
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02440913
5Fatty acid degradation_Homo sapiens_hsa000712.83186043
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79842855
7Arginine biosynthesis_Homo sapiens_hsa002202.79319125
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74989877
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.71266311
10Tryptophan metabolism_Homo sapiens_hsa003802.68031499
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43462641
12Complement and coagulation cascades_Homo sapiens_hsa046102.36623291
13Propanoate metabolism_Homo sapiens_hsa006402.36503922
14Butanoate metabolism_Homo sapiens_hsa006502.34236060
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27913492
16Peroxisome_Homo sapiens_hsa041462.21706985
17Fatty acid metabolism_Homo sapiens_hsa012122.13889869
18PPAR signaling pathway_Homo sapiens_hsa033202.10189816
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02112795
20beta-Alanine metabolism_Homo sapiens_hsa004101.88052355
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84520157
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83645078
23Chemical carcinogenesis_Homo sapiens_hsa052041.83538020
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81837713
25Histidine metabolism_Homo sapiens_hsa003401.81672901
26Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.80749918
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.75182600
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66674451
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.65038290
30Pyruvate metabolism_Homo sapiens_hsa006201.58735464
31Caffeine metabolism_Homo sapiens_hsa002321.57472760
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56540099
33Other glycan degradation_Homo sapiens_hsa005111.53157113
34Fatty acid elongation_Homo sapiens_hsa000621.52424088
35Staphylococcus aureus infection_Homo sapiens_hsa051501.48283636
36Selenocompound metabolism_Homo sapiens_hsa004501.47481740
37Bile secretion_Homo sapiens_hsa049761.47410371
38* Retinol metabolism_Homo sapiens_hsa008301.46854131
39Phenylalanine metabolism_Homo sapiens_hsa003601.46409570
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41867921
41Sulfur metabolism_Homo sapiens_hsa009201.40798347
42Carbon metabolism_Homo sapiens_hsa012001.36070018
43Tyrosine metabolism_Homo sapiens_hsa003501.34314484
44Starch and sucrose metabolism_Homo sapiens_hsa005001.31806797
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.25168983
46Biosynthesis of amino acids_Homo sapiens_hsa012301.24305212
47Fat digestion and absorption_Homo sapiens_hsa049751.22797223
48Folate biosynthesis_Homo sapiens_hsa007901.22221513
49ABC transporters_Homo sapiens_hsa020101.14218521
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.07487193
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01417120
52Steroid biosynthesis_Homo sapiens_hsa001001.01090019
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00073756
54Arginine and proline metabolism_Homo sapiens_hsa003300.99560451
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98923419
56Sulfur relay system_Homo sapiens_hsa041220.98275067
57Vitamin digestion and absorption_Homo sapiens_hsa049770.96574797
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94005607
59Vitamin B6 metabolism_Homo sapiens_hsa007500.92708165
60Lysine degradation_Homo sapiens_hsa003100.89754543
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85322693
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83689994
63Glycerolipid metabolism_Homo sapiens_hsa005610.82752982
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.82169458
65Fatty acid biosynthesis_Homo sapiens_hsa000610.79321779
66Glutathione metabolism_Homo sapiens_hsa004800.76258538
67One carbon pool by folate_Homo sapiens_hsa006700.68085611
68Pentose phosphate pathway_Homo sapiens_hsa000300.67360399
69ECM-receptor interaction_Homo sapiens_hsa045120.66226085
70Metabolic pathways_Homo sapiens_hsa011000.50504546
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43252136
72Fructose and mannose metabolism_Homo sapiens_hsa000510.40134927
73Focal adhesion_Homo sapiens_hsa045100.37593625
74Galactose metabolism_Homo sapiens_hsa000520.37542636
75Renin secretion_Homo sapiens_hsa049240.37122447
76Sphingolipid metabolism_Homo sapiens_hsa006000.32750900
77Pertussis_Homo sapiens_hsa051330.32636901
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32582654
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.32413985
80Amoebiasis_Homo sapiens_hsa051460.29659409
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28727795
82Insulin resistance_Homo sapiens_hsa049310.27698707
83Thyroid cancer_Homo sapiens_hsa052160.27517432
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24387108
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23302218
86Linoleic acid metabolism_Homo sapiens_hsa005910.21324459
87Prion diseases_Homo sapiens_hsa050200.20512440
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18034019
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.17902146
90Acute myeloid leukemia_Homo sapiens_hsa052210.16889965
91GnRH signaling pathway_Homo sapiens_hsa049120.15948344
92Adherens junction_Homo sapiens_hsa045200.14567028
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14189792
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.13310622
95Proteoglycans in cancer_Homo sapiens_hsa052050.12846563
96Glucagon signaling pathway_Homo sapiens_hsa049220.11833543
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10902502
98AMPK signaling pathway_Homo sapiens_hsa041520.09589204
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2225407
100Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2180739
101Lysosome_Homo sapiens_hsa04142-0.2100594
102Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2087549
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2028538
104African trypanosomiasis_Homo sapiens_hsa05143-0.2018090
105Protein digestion and absorption_Homo sapiens_hsa04974-0.1924701
106Hepatitis C_Homo sapiens_hsa05160-0.1793682
107Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1722690
108Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1702636
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1633692
110Regulation of autophagy_Homo sapiens_hsa04140-0.1631983
111Mineral absorption_Homo sapiens_hsa04978-0.1620677
112Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1281430
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1014744
114Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0777061
115Insulin signaling pathway_Homo sapiens_hsa04910-0.0668905
116Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0499748
117Renin-angiotensin system_Homo sapiens_hsa04614-0.0344866
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0037720

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