REV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interkinetic nuclear migration (GO:0022027)6.36477980
2nuclear pore complex assembly (GO:0051292)6.21729855
3nuclear pore organization (GO:0006999)5.87942341
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.17118837
5pore complex assembly (GO:0046931)4.65340949
6DNA unwinding involved in DNA replication (GO:0006268)4.64711416
7mitotic sister chromatid cohesion (GO:0007064)4.61845712
8protein localization to kinetochore (GO:0034501)4.57408514
9regulation of histone H3-K9 methylation (GO:0051570)4.49783990
10mitotic chromosome condensation (GO:0007076)4.36887859
11sister chromatid segregation (GO:0000819)4.33070891
12mitotic sister chromatid segregation (GO:0000070)4.16457144
13dosage compensation (GO:0007549)4.13543133
14nucleus localization (GO:0051647)4.12851862
15negative regulation of histone methylation (GO:0031061)4.06159659
16pre-miRNA processing (GO:0031054)4.00701783
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.98581092
18negative regulation of translation, ncRNA-mediated (GO:0040033)3.98581092
19regulation of translation, ncRNA-mediated (GO:0045974)3.98581092
20kinetochore organization (GO:0051383)3.98141988
21DNA replication-dependent nucleosome assembly (GO:0006335)3.97404744
22DNA replication-dependent nucleosome organization (GO:0034723)3.97404744
23protein localization to chromosome, centromeric region (GO:0071459)3.93157259
24mitotic nuclear envelope disassembly (GO:0007077)3.92493086
25DNA geometric change (GO:0032392)3.89957237
26DNA duplex unwinding (GO:0032508)3.85519124
27positive regulation of histone H3-K4 methylation (GO:0051571)3.85121745
28mitotic metaphase plate congression (GO:0007080)3.84411722
29centriole replication (GO:0007099)3.82359624
30positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.82098041
31positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.82098041
32positive regulation of mitotic sister chromatid separation (GO:1901970)3.82098041
33meiotic chromosome segregation (GO:0045132)3.81923927
34regulation of protein polyubiquitination (GO:1902914)3.80132118
35regulation of DNA endoreduplication (GO:0032875)3.78729970
36somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75503414
37somatic hypermutation of immunoglobulin genes (GO:0016446)3.75503414
38histone H2A monoubiquitination (GO:0035518)3.75422979
39nuclear envelope disassembly (GO:0051081)3.74072148
40membrane disassembly (GO:0030397)3.74072148
41regulation of centriole replication (GO:0046599)3.72617411
42protein localization to chromosome (GO:0034502)3.72505301
43chromatin assembly (GO:0031497)3.72032662
44DNA replication-independent nucleosome organization (GO:0034724)3.63706904
45DNA replication-independent nucleosome assembly (GO:0006336)3.63706904
46DNA replication initiation (GO:0006270)3.63126587
47chromatin remodeling at centromere (GO:0031055)3.62630083
48histone H3-K4 trimethylation (GO:0080182)3.62358485
49sister chromatid cohesion (GO:0007062)3.62150941
50heparin metabolic process (GO:0030202)3.59133273
51heparin biosynthetic process (GO:0030210)3.59133273
52metaphase plate congression (GO:0051310)3.52663134
53regulation of spindle organization (GO:0090224)3.50444606
54chromatin assembly or disassembly (GO:0006333)3.48844552
55phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.48494831
56regulation of sister chromatid cohesion (GO:0007063)3.47473994
57CENP-A containing nucleosome assembly (GO:0034080)3.46455931
58positive regulation of chromosome segregation (GO:0051984)3.46088634
59cytoplasmic mRNA processing body assembly (GO:0033962)3.45165261
60regulation of RNA export from nucleus (GO:0046831)3.42449385
61gene silencing by RNA (GO:0031047)3.41959777
62protein K6-linked ubiquitination (GO:0085020)3.41443579
63DNA conformation change (GO:0071103)3.39990290
64heterochromatin organization (GO:0070828)3.39578614
65attachment of spindle microtubules to kinetochore (GO:0008608)3.38024174
66histone exchange (GO:0043486)3.37340660
67regulation of double-strand break repair (GO:2000779)3.35637270
68IMP biosynthetic process (GO:0006188)3.34631926
69DNA topological change (GO:0006265)3.31051980
70peptidyl-lysine trimethylation (GO:0018023)3.29878474
71regulation of DNA methylation (GO:0044030)3.29683219
72regulation of double-strand break repair via homologous recombination (GO:0010569)3.28903553
73histone H2A acetylation (GO:0043968)3.28819612
74regulation of centrosome cycle (GO:0046605)3.28760096
75regulation of histone H3-K4 methylation (GO:0051569)3.28695927
76kinetochore assembly (GO:0051382)3.27006985
77regulation of chromosome segregation (GO:0051983)3.26438791
78establishment of chromosome localization (GO:0051303)3.25628533
79piRNA metabolic process (GO:0034587)3.25499634
80monoubiquitinated protein deubiquitination (GO:0035520)3.24580736
81regulation of centrosome duplication (GO:0010824)3.23837654
82ATP-dependent chromatin remodeling (GO:0043044)3.23062043
83negative regulation of DNA repair (GO:0045738)3.22878789
84spindle checkpoint (GO:0031577)3.22224741
85regulation of mitotic metaphase/anaphase transition (GO:0030071)3.20847195
86regulation of posttranscriptional gene silencing (GO:0060147)3.20411486
87regulation of gene silencing by miRNA (GO:0060964)3.20411486
88regulation of gene silencing by RNA (GO:0060966)3.20411486
89reciprocal meiotic recombination (GO:0007131)3.19139487
90reciprocal DNA recombination (GO:0035825)3.19139487
91histone H3-K9 demethylation (GO:0033169)3.18030881
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17372061
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.16942861
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.16882938
95regulation of mitotic sister chromatid separation (GO:0010965)3.16864375
96regulation of mitotic sister chromatid segregation (GO:0033047)3.16864375
97regulation of sister chromatid segregation (GO:0033045)3.16864375
98regulation of mitotic spindle organization (GO:0060236)3.16856384
99chromosome segregation (GO:0007059)3.16492416
100mitotic recombination (GO:0006312)3.14716420
101resolution of meiotic recombination intermediates (GO:0000712)3.12921105
102regulation of nuclear cell cycle DNA replication (GO:0033262)3.12763052
103regulation of meiosis I (GO:0060631)3.12109382
104regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12045256
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.11638228
106regulation of helicase activity (GO:0051095)3.11552638
107microtubule depolymerization (GO:0007019)3.11280443
108negative regulation of chromosome segregation (GO:0051985)3.11140969
109DNA packaging (GO:0006323)3.11090460
110mRNA transport (GO:0051028)3.10708496
111spindle assembly checkpoint (GO:0071173)3.10406358
112DNA replication checkpoint (GO:0000076)3.09356313
113intra-S DNA damage checkpoint (GO:0031573)3.08852626
114replication fork processing (GO:0031297)3.06434403
115nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.06040834
116regulation of histone methylation (GO:0031060)3.05253002
117negative regulation of mitotic sister chromatid separation (GO:2000816)3.04702648
118negative regulation of mitotic sister chromatid segregation (GO:0033048)3.04702648
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.04702648
120negative regulation of sister chromatid segregation (GO:0033046)3.04702648
121centriole assembly (GO:0098534)3.01682957
122regulation of nucleobase-containing compound transport (GO:0032239)2.94169500
123Golgi to endosome transport (GO:0006895)2.93054584
124microtubule anchoring (GO:0034453)2.91512223
125negative regulation of smooth muscle cell differentiation (GO:0051151)2.88471049
126histone H3-K4 methylation (GO:0051568)2.87960770
127poly(A)+ mRNA export from nucleus (GO:0016973)2.86161844
128histone H4-K16 acetylation (GO:0043984)2.85995869
129establishment of protein localization to Golgi (GO:0072600)2.85410317
130regulation of establishment of cell polarity (GO:2000114)2.81652447
131neural tube formation (GO:0001841)2.79527006
132synapsis (GO:0007129)2.73332433
133negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.71823288
134positive regulation of cell cycle checkpoint (GO:1901978)2.71558203
135centrosome duplication (GO:0051298)2.71459286
136regulation of sarcomere organization (GO:0060297)2.70670579
137otic vesicle formation (GO:0030916)2.69805132
138histone lysine methylation (GO:0034968)2.68365560
139DNA methylation involved in gamete generation (GO:0043046)2.68255744
140protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.66852229
141meiotic cell cycle (GO:0051321)2.65962261
142negative regulation of cell cycle G2/M phase transition (GO:1902750)2.65289638
143phosphorelay signal transduction system (GO:0000160)2.64598012
144regulation of pigment cell differentiation (GO:0050932)2.63907365
145peptidyl-lysine methylation (GO:0018022)2.62488053
146dentate gyrus development (GO:0021542)2.62423224
147regulation of Rac protein signal transduction (GO:0035020)2.62192914
148definitive hemopoiesis (GO:0060216)2.61140843
149phosphatidylinositol dephosphorylation (GO:0046856)2.59919972
150establishment of nucleus localization (GO:0040023)2.58041919
151cAMP catabolic process (GO:0006198)2.57577402
152negative regulation of DNA recombination (GO:0045910)2.56453836
153histone lysine demethylation (GO:0070076)2.56161839
154retrograde transport, vesicle recycling within Golgi (GO:0000301)2.55940833
155protein targeting to Golgi (GO:0000042)2.55676494
156myofibril assembly (GO:0030239)2.54754011
157positive regulation of histone methylation (GO:0031062)2.54181631
158positive regulation of DNA-templated transcription, initiation (GO:2000144)2.53741807
159histone H3-K36 demethylation (GO:0070544)2.53542077
160phospholipid dephosphorylation (GO:0046839)2.52911609
161peptidyl-threonine phosphorylation (GO:0018107)2.52673835
162histone H3-K9 methylation (GO:0051567)2.50754325
163cyclic nucleotide catabolic process (GO:0009214)2.48838426
164cellular response to ethanol (GO:0071361)2.45745584
165cardiac muscle hypertrophy (GO:0003300)2.45489969
166protein K48-linked deubiquitination (GO:0071108)2.44214338
167positive regulation of catenin import into nucleus (GO:0035413)2.40894372
168negative regulation of neurotransmitter secretion (GO:0046929)2.39982359
169histone demethylation (GO:0016577)2.39870622
170microtubule organizing center organization (GO:0031023)2.39483309
171embryonic retina morphogenesis in camera-type eye (GO:0060059)2.39467803
172retinal cone cell development (GO:0046549)2.39118920

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.06154711
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.82028872
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.60416254
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.51327822
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.46371588
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.17067073
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.13992078
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.10622379
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.77695804
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.72954790
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65555443
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63635034
13* RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52512523
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41836550
15GBX2_23144817_ChIP-Seq_PC3_Human2.37595021
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.35843275
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.32140040
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16772175
19MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15011594
20AR_21909140_ChIP-Seq_LNCAP_Human2.13102838
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10920990
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10381771
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06330094
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05107097
25EZH2_22144423_ChIP-Seq_EOC_Human2.03926740
26* FLI1_27457419_Chip-Seq_LIVER_Mouse2.02275789
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00570223
28E2F7_22180533_ChIP-Seq_HELA_Human11.5389221
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94619444
30MYC_22102868_ChIP-Seq_BL_Human1.93179675
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89830890
32TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.87352189
33CIITA_25753668_ChIP-Seq_RAJI_Human1.80422632
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80182442
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79681887
36* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76498480
37SMAD4_21799915_ChIP-Seq_A2780_Human1.76071114
38SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.74941111
39* STAT3_23295773_ChIP-Seq_U87_Human1.70964199
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70301317
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69811111
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.67354089
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.67083780
44VDR_22108803_ChIP-Seq_LS180_Human1.64676554
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.62416806
46* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62358183
47* P300_19829295_ChIP-Seq_ESCs_Human1.62349693
48SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62213404
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62121499
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61951189
51* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60297248
52IGF1R_20145208_ChIP-Seq_DFB_Human1.60134621
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.56941655
54* EZH2_27294783_Chip-Seq_NPCs_Mouse1.56826707
55* TCF4_23295773_ChIP-Seq_U87_Human1.56787993
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.55064680
57* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53397626
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.52770571
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.52199439
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51992771
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51036883
62ER_23166858_ChIP-Seq_MCF-7_Human1.49188002
63* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46938505
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46897758
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45817693
66ELK1_19687146_ChIP-ChIP_HELA_Human1.44816752
67KDM5A_27292631_Chip-Seq_BREAST_Human1.44720751
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44425316
69BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43190530
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42450984
71* E2F1_18555785_Chip-Seq_ESCs_Mouse1.42194721
72TAF15_26573619_Chip-Seq_HEK293_Human1.41280728
73* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41071000
74* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.39567032
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39447597
76VDR_23849224_ChIP-Seq_CD4+_Human1.39007348
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.36793382
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36717428
79* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36511804
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.36303376
81MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34942214
82FOXP3_21729870_ChIP-Seq_TREG_Human1.34735079
83* NFE2_27457419_Chip-Seq_LIVER_Mouse1.34112413
84SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33385644
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33102305
86* P53_22387025_ChIP-Seq_ESCs_Mouse1.31796645
87CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.31253542
88AR_21572438_ChIP-Seq_LNCaP_Human1.30359675
89* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30223670
90ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29670289
91XRN2_22483619_ChIP-Seq_HELA_Human1.29569632
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.29289840
93* SMAD3_21741376_ChIP-Seq_EPCs_Human1.29117790
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28706718
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28431469
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28431469
97TP53_16413492_ChIP-PET_HCT116_Human1.27635004
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26843179
99AHR_22903824_ChIP-Seq_MCF-7_Human1.26735562
100* CMYC_18555785_Chip-Seq_ESCs_Mouse1.26496705
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26391093
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25741462
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25235145
104SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23737887
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.23353179
106CBP_20019798_ChIP-Seq_JUKART_Human1.22392799
107IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22392799
108* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22143020
109CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20050581
110* AR_25329375_ChIP-Seq_VCAP_Human1.19351848
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19156673
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19018832
113STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17381409
114* TFEB_21752829_ChIP-Seq_HELA_Human1.17326303
115ZNF274_21170338_ChIP-Seq_K562_Hela1.16483892
116EP300_21415370_ChIP-Seq_HL-1_Mouse1.16386935
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.15717991
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.14920251
119BCAT_22108803_ChIP-Seq_LS180_Human1.13787904
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13455265
121* CRX_20693478_ChIP-Seq_RETINA_Mouse1.13026073
122* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12601013
123* RUNX2_22187159_ChIP-Seq_PCA_Human1.12039977
124* P300_18555785_Chip-Seq_ESCs_Mouse1.11154569
125* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09953805
126HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09887433
127NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09796101
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09627925
129E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09563160
130* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09377956
131RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08805510
132* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08726276
133* NMYC_18555785_Chip-Seq_ESCs_Mouse1.08292411
134TTF2_22483619_ChIP-Seq_HELA_Human1.07463274
135SOX2_21211035_ChIP-Seq_LN229_Gbm1.07454116
136* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07164410
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.06888713
138KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05450639
139KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05450639
140KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05450639
141* STAT3_18555785_Chip-Seq_ESCs_Mouse1.05202774
142TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04852862
143* OCT4_18555785_Chip-Seq_ESCs_Mouse1.04356532
144YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04320075
145POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.03945790
146* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03488338
147* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03061927
148THAP11_20581084_ChIP-Seq_MESCs_Mouse1.03054451
149NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.02620758
150TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02209423
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02191465
152FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01634717
153SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00912069
154ESR1_20079471_ChIP-ChIP_T-47D_Human1.00481117
155* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98289935
156* TCF7_22412390_ChIP-Seq_EML_Mouse0.97622687
157PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97580676
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97344993
159SCL_19346495_ChIP-Seq_HPC-7_Human0.96992696
160POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96678284
161CREB1_15753290_ChIP-ChIP_HEK293T_Human0.95030051
162FUS_26573619_Chip-Seq_HEK293_Human0.94157499
163E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92506099
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91985575
165CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90947612
166ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90388244
167PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90280546
168SOX2_16153702_ChIP-ChIP_HESCs_Human0.89808863
169SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88346312
170POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.87632362
171KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87045055
172CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87034836
173GABP_19822575_ChIP-Seq_HepG2_Human0.86907127
174* EWS_26573619_Chip-Seq_HEK293_Human0.86545746
175TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85732687
176GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84172757
177ETS1_20019798_ChIP-Seq_JURKAT_Human0.82755185
178SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.80446819
179NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.78852343
180NANOG_16153702_ChIP-ChIP_HESCs_Human0.78533384
181DCP1A_22483619_ChIP-Seq_HELA_Human0.78173418
182CHD1_26751641_Chip-Seq_LNCaP_Human0.76838355
183NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76110055
184* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.74760668
185SOX2_18692474_ChIP-Seq_MESCs_Mouse0.74306238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.59739487
2MP0008877_abnormal_DNA_methylation4.07345242
3MP0003111_abnormal_nucleus_morphology3.76388085
4MP0008057_abnormal_DNA_replication3.76231065
5MP0003077_abnormal_cell_cycle3.32618378
6MP0003787_abnormal_imprinting3.28081702
7MP0003693_abnormal_embryo_hatching3.20225200
8MP0008058_abnormal_DNA_repair3.15556395
9MP0003123_paternal_imprinting3.01224029
10MP0003121_genomic_imprinting2.92664701
11MP0008007_abnormal_cellular_replicative2.88086580
12MP0010307_abnormal_tumor_latency2.81176138
13MP0004957_abnormal_blastocyst_morpholog2.80189268
14MP0002396_abnormal_hematopoietic_system2.71660322
15MP0000566_synostosis2.51094758
16MP0010352_gastrointestinal_tract_polyps2.33666404
17MP0000569_abnormal_digit_pigmentation2.30724983
18MP0000350_abnormal_cell_proliferation2.20756502
19MP0003890_abnormal_embryonic-extraembry2.17947779
20MP0001730_embryonic_growth_arrest2.09112851
21MP0004808_abnormal_hematopoietic_stem2.08740150
22MP0005076_abnormal_cell_differentiation2.01400332
23MP0004084_abnormal_cardiac_muscle2.01013038
24MP0002837_dystrophic_cardiac_calcinosis1.95024418
25MP0004197_abnormal_fetal_growth/weight/1.86022725
26MP0001672_abnormal_embryogenesis/_devel1.85815255
27MP0005380_embryogenesis_phenotype1.85815255
28MP0002084_abnormal_developmental_patter1.75759268
29MP0002210_abnormal_sex_determination1.75318079
30MP0003984_embryonic_growth_retardation1.75188587
31MP0000427_abnormal_hair_cycle1.74615453
32MP0003718_maternal_effect1.72201351
33MP0002088_abnormal_embryonic_growth/wei1.70718693
34MP0003656_abnormal_erythrocyte_physiolo1.68869083
35MP0001697_abnormal_embryo_size1.66507899
36MP0004145_abnormal_muscle_electrophysio1.61761567
37MP0005409_darkened_coat_color1.59414207
38MP0002085_abnormal_embryonic_tissue1.58471677
39MP0003786_premature_aging1.58247046
40MP0002086_abnormal_extraembryonic_tissu1.55968917
41MP0001929_abnormal_gametogenesis1.55098641
42MP0005499_abnormal_olfactory_system1.54138310
43MP0005394_taste/olfaction_phenotype1.54138310
44MP0000383_abnormal_hair_follicle1.46145277
45MP0003646_muscle_fatigue1.46045950
46MP0008789_abnormal_olfactory_epithelium1.45809011
47MP0001145_abnormal_male_reproductive1.45455550
48MP0010234_abnormal_vibrissa_follicle1.45363106
49MP0004264_abnormal_extraembryonic_tissu1.44545908
50MP0003567_abnormal_fetal_cardiomyocyte1.43014592
51MP0003705_abnormal_hypodermis_morpholog1.39590119
52MP0003950_abnormal_plasma_membrane1.38547094
53MP0004036_abnormal_muscle_relaxation1.38446129
54* MP0002080_prenatal_lethality1.36624958
55MP0002160_abnormal_reproductive_system1.34839999
56MP0008932_abnormal_embryonic_tissue1.33640655
57MP0001293_anophthalmia1.33196294
58MP0009703_decreased_birth_body1.32093941
59MP0000653_abnormal_sex_gland1.31789168
60MP0005220_abnormal_exocrine_pancreas1.30834622
61MP0000313_abnormal_cell_death1.29500060
62MP0005075_abnormal_melanosome_morpholog1.26415835
63MP0004215_abnormal_myocardial_fiber1.25975912
64MP0010678_abnormal_skin_adnexa1.25115074
65MP0001915_intracranial_hemorrhage1.21884189
66MP0002166_altered_tumor_susceptibility1.19350433
67MP0008995_early_reproductive_senescence1.18688021
68MP0005395_other_phenotype1.18360181
69MP0004043_abnormal_pH_regulation1.18141897
70MP0004147_increased_porphyrin_level1.17831600
71MP0009697_abnormal_copulation1.17454677
72MP0003183_abnormal_peptide_metabolism1.15013844
73MP0001661_extended_life_span1.14982126
74MP0003698_abnormal_male_reproductive1.14367582
75MP0005397_hematopoietic_system_phenotyp1.11401665
76MP0001545_abnormal_hematopoietic_system1.11401665
77MP0002019_abnormal_tumor_incidence1.11125451
78MP0002653_abnormal_ependyma_morphology1.11111879
79MP0001119_abnormal_female_reproductive1.09583118
80MP0004133_heterotaxia1.07115690
81MP0009115_abnormal_fat_cell1.06726041
82MP0004185_abnormal_adipocyte_glucose1.05598744
83MP0009672_abnormal_birth_weight1.01064416
84MP0002269_muscular_atrophy0.99986488
85MP0005389_reproductive_system_phenotype0.98945420
86MP0010368_abnormal_lymphatic_system0.97874846
87MP0000490_abnormal_crypts_of0.95576907
88MP0009278_abnormal_bone_marrow0.94625962
89MP0006292_abnormal_olfactory_placode0.94228322
90MP0003943_abnormal_hepatobiliary_system0.94162389
91MP0002877_abnormal_melanocyte_morpholog0.93184774
92MP0002006_tumorigenesis0.93078286
93MP0003861_abnormal_nervous_system0.92265393
94MP0000371_diluted_coat_color0.90554615
95MP0002697_abnormal_eye_size0.90051399
96MP0000733_abnormal_muscle_development0.90024214
97MP0001177_atelectasis0.89777989
98MP0001286_abnormal_eye_development0.89581269
99MP0000703_abnormal_thymus_morphology0.88757295
100MP0002168_other_aberrant_phenotype0.88524191
101MP0001299_abnormal_eye_distance/0.87800561
102MP0002925_abnormal_cardiovascular_devel0.86421116
103MP0010630_abnormal_cardiac_muscle0.84821125
104MP0003119_abnormal_digestive_system0.84021650
105MP0006138_congestive_heart_failure0.83677931
106MP0002075_abnormal_coat/hair_pigmentati0.83293108
107MP0005384_cellular_phenotype0.81106796
108MP0002161_abnormal_fertility/fecundity0.80720860
109MP0001849_ear_inflammation0.80710788
110MP0004885_abnormal_endolymph0.79924018
111MP0005621_abnormal_cell_physiology0.79648557
112MP0001944_abnormal_pancreas_morphology0.78995777
113MP0001188_hyperpigmentation0.78745302
114MP0002111_abnormal_tail_morphology0.78300235
115MP0003122_maternal_imprinting0.78186304
116MP0010030_abnormal_orbit_morphology0.77483623
117MP0003868_abnormal_feces_composition0.76861572
118MP0003115_abnormal_respiratory_system0.76392983
119MP0004087_abnormal_muscle_fiber0.76114651
120MP0009053_abnormal_anal_canal0.75714492
121MP0000015_abnormal_ear_pigmentation0.75356850
122MP0002092_abnormal_eye_morphology0.74867169
123MP0009780_abnormal_chondrocyte_physiolo0.74789781
124* MP0002398_abnormal_bone_marrow0.74226466
125MP0003935_abnormal_craniofacial_develop0.74195943
126MP0005174_abnormal_tail_pigmentation0.73358221
127MP0002106_abnormal_muscle_physiology0.71373964
128MP0008775_abnormal_heart_ventricle0.69587623
129MP0008770_decreased_survivor_rate0.69514026
130MP0005666_abnormal_adipose_tissue0.68685118
131MP0005379_endocrine/exocrine_gland_phen0.68602186
132MP0003699_abnormal_female_reproductive0.68569358
133MP0003937_abnormal_limbs/digits/tail_de0.67055036
134MP0005266_abnormal_metabolism0.66493068
135MP0000428_abnormal_craniofacial_morphol0.66043244
136MP0004130_abnormal_muscle_cell0.62628303
137MP0001784_abnormal_fluid_regulation0.62483350
138MP0000266_abnormal_heart_morphology0.61258475
139MP0003566_abnormal_cell_adhesion0.61135600
140MP0002095_abnormal_skin_pigmentation0.61007592
141MP0005367_renal/urinary_system_phenotyp0.60651300
142MP0000516_abnormal_urinary_system0.60651300
143MP0000432_abnormal_head_morphology0.60342701
144MP0000689_abnormal_spleen_morphology0.60208523
145MP0003755_abnormal_palate_morphology0.60074015
146MP0002938_white_spotting0.60011116
147MP0002009_preneoplasia0.58659511

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.71090480
2Ependymoma (HP:0002888)3.69628070
3Abnormality of the labia minora (HP:0012880)3.62430172
4Fair hair (HP:0002286)3.57279332
5Chromsome breakage (HP:0040012)3.49783975
6Medulloblastoma (HP:0002885)3.35234346
7Birth length less than 3rd percentile (HP:0003561)3.27932381
8Abnormality of the fingertips (HP:0001211)3.23016563
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.22618165
10Abnormality of chromosome stability (HP:0003220)3.11253644
11Abnormality of the astrocytes (HP:0100707)3.09691593
12Astrocytoma (HP:0009592)3.09691593
13Gaze-evoked nystagmus (HP:0000640)2.90680755
14Hyperventilation (HP:0002883)2.87225487
15Neoplasm of the oral cavity (HP:0100649)2.85625575
16Acute lymphatic leukemia (HP:0006721)2.84228764
17Tubulointerstitial nephritis (HP:0001970)2.81129083
18Glioma (HP:0009733)2.79043793
19Abnormal hair whorl (HP:0010721)2.75424045
20Hypoplastic nipples (HP:0002557)2.73938206
21Rhabdomyosarcoma (HP:0002859)2.71475696
22Short 4th metacarpal (HP:0010044)2.70065812
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70065812
24Impulsivity (HP:0100710)2.68995800
25Aqueductal stenosis (HP:0002410)2.67020591
26Myelodysplasia (HP:0002863)2.64436253
27Chronic hepatic failure (HP:0100626)2.63940767
28Prominent nose (HP:0000448)2.62082069
29Colon cancer (HP:0003003)2.61026635
30Meckel diverticulum (HP:0002245)2.60734446
31Facial hemangioma (HP:0000329)2.60216707
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.58527560
33Generalized hypopigmentation of hair (HP:0011358)2.57651571
34Renal cortical cysts (HP:0000803)2.56040293
35Acute myeloid leukemia (HP:0004808)2.55461810
36Heterotopia (HP:0002282)2.54929396
37Papillary thyroid carcinoma (HP:0002895)2.54915702
38Supernumerary spleens (HP:0009799)2.54174589
39Abnormality of the ileum (HP:0001549)2.52503549
40Agnosia (HP:0010524)2.50651395
41Abnormality of the renal cortex (HP:0011035)2.50515399
42Urethral obstruction (HP:0000796)2.49681785
43Patellar aplasia (HP:0006443)2.42613447
44Increased nuchal translucency (HP:0010880)2.42039135
45Ectopic kidney (HP:0000086)2.38272747
46Diastasis recti (HP:0001540)2.31819145
47Nephroblastoma (Wilms tumor) (HP:0002667)2.31015513
48Neoplasm of striated muscle (HP:0009728)2.30658422
49Abnormality of the preputium (HP:0100587)2.30264176
50Truncal obesity (HP:0001956)2.28957185
51Gastrointestinal carcinoma (HP:0002672)2.28019055
52Malignant gastrointestinal tract tumors (HP:0006749)2.28019055
53Abnormality of the carotid arteries (HP:0005344)2.26689328
54Cutaneous melanoma (HP:0012056)2.26580514
55Nephronophthisis (HP:0000090)2.26089754
56Cafe-au-lait spot (HP:0000957)2.25962533
57Degeneration of anterior horn cells (HP:0002398)2.25559648
58Abnormality of the anterior horn cell (HP:0006802)2.25559648
59Biliary tract neoplasm (HP:0100574)2.20966383
60Hypoglycemic coma (HP:0001325)2.20528259
61Abnormality of the labia majora (HP:0012881)2.20156651
62Intestinal atresia (HP:0011100)2.19090126
63Deviation of the thumb (HP:0009603)2.18242365
64Abnormality of the lower motor neuron (HP:0002366)2.18184785
65Pelvic girdle muscle weakness (HP:0003749)2.18162042
66Sandal gap (HP:0001852)2.17674991
67Small intestinal stenosis (HP:0012848)2.16018564
68Duodenal stenosis (HP:0100867)2.16018564
69Neoplasm of the small intestine (HP:0100833)2.15383477
70Aplasia/Hypoplasia of the patella (HP:0006498)2.14821409
71Basal cell carcinoma (HP:0002671)2.14489852
72Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.13148106
73Abnormality of the renal medulla (HP:0100957)2.12926817
74Clitoromegaly (HP:0000057)2.12544935
75Neoplasm of the adrenal cortex (HP:0100641)2.11673815
76Deep philtrum (HP:0002002)2.11535944
77Long eyelashes (HP:0000527)2.11268698
78Embryonal renal neoplasm (HP:0011794)2.10371950
79Sloping forehead (HP:0000340)2.07807724
80Subaortic stenosis (HP:0001682)2.07771808
81Abnormality of the left ventricular outflow tract (HP:0011103)2.07771808
82Pancreatic islet-cell hyperplasia (HP:0004510)2.06929883
83Low anterior hairline (HP:0000294)2.05080237
8411 pairs of ribs (HP:0000878)2.04347334
85Renal hypoplasia (HP:0000089)2.03630371
86Bifid scrotum (HP:0000048)2.03115719
87Proximal placement of thumb (HP:0009623)2.01585619
88Abnormality of midbrain morphology (HP:0002418)2.00971335
89Molar tooth sign on MRI (HP:0002419)2.00971335
90Skull defect (HP:0001362)2.00225153
91Capillary hemangiomas (HP:0005306)1.99242840
92Hypoglycemic seizures (HP:0002173)1.99144429
93Macroorchidism (HP:0000053)1.98962935
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.98521714
95Anteriorly placed anus (HP:0001545)1.94159681
96Abnormality of the ischium (HP:0003174)1.93397370
97Uterine leiomyosarcoma (HP:0002891)1.93328744
98Leiomyosarcoma (HP:0100243)1.93328744
99High pitched voice (HP:0001620)1.93131862
100Transitional cell carcinoma of the bladder (HP:0006740)1.92353958
101Dysmetric saccades (HP:0000641)1.91394887
102Cystic hygroma (HP:0000476)1.90617680
103Abnormality of the duodenum (HP:0002246)1.89982930
104Broad thumb (HP:0011304)1.89739317
105Acanthocytosis (HP:0001927)1.88084045
106Hepatoblastoma (HP:0002884)1.87438612
107Cortical dysplasia (HP:0002539)1.85685556
108Enlarged penis (HP:0000040)1.85253392
109Metaphyseal dysplasia (HP:0100255)1.85106470
110Central scotoma (HP:0000603)1.84616071
111Missing ribs (HP:0000921)1.84553458
112Squamous cell carcinoma (HP:0002860)1.83809885
113Calf muscle hypertrophy (HP:0008981)1.83207934
114Hyperkalemia (HP:0002153)1.82917315
115Cutis marmorata (HP:0000965)1.82606591
116Selective tooth agenesis (HP:0001592)1.82367576
117Absent thumb (HP:0009777)1.81455948
118Abnormal biliary tract morphology (HP:0012440)1.81211703
119Abnormality of lateral ventricle (HP:0030047)1.80752955
120Hypoplastic labia majora (HP:0000059)1.79890549
121Abnormality of chromosome segregation (HP:0002916)1.79434903
122Vertebral arch anomaly (HP:0008438)1.79303735
123Uterine neoplasm (HP:0010784)1.78941478
124Thyroid carcinoma (HP:0002890)1.77761921
125Broad palm (HP:0001169)1.77686398
126Long clavicles (HP:0000890)1.77668887
127Wide intermamillary distance (HP:0006610)1.77405499
128Spinal cord lesions (HP:0100561)1.77058781
129Syringomyelia (HP:0003396)1.77058781
130Oligodactyly (hands) (HP:0001180)1.76419219
131Protruding tongue (HP:0010808)1.75871263
132Bone marrow hypocellularity (HP:0005528)1.75825089
133Asymmetry of the thorax (HP:0001555)1.75794209
134Spinal muscular atrophy (HP:0007269)1.75612852
135Abnormality of the 4th metacarpal (HP:0010012)1.75212941
136Hypochromic microcytic anemia (HP:0004840)1.74892652
137Abnormality of the musculature of the pelvis (HP:0001469)1.74798386
138Abnormality of the hip-girdle musculature (HP:0001445)1.74798386
139Abnormality of DNA repair (HP:0003254)1.74778936
140Shawl scrotum (HP:0000049)1.74778847
141Scotoma (HP:0000575)1.73982660
142Widely spaced teeth (HP:0000687)1.73718211
143Broad-based gait (HP:0002136)1.73713344
144Gastrointestinal atresia (HP:0002589)1.73448568
145Intellectual disability, moderate (HP:0002342)1.73256980
146Genital tract atresia (HP:0001827)1.72554470
147Hyperglycemia (HP:0003074)1.72193831
148Renovascular hypertension (HP:0100817)1.71437390
149Absent frontal sinuses (HP:0002688)1.71348878
150Ovarian neoplasm (HP:0100615)1.70996994
151Clubbing of toes (HP:0100760)1.70140859
152Supernumerary ribs (HP:0005815)1.69907248
153Hypoplastic ischia (HP:0003175)1.69220088
154Microglossia (HP:0000171)1.69098371
155Obsessive-compulsive behavior (HP:0000722)1.69068999
156Narrow palate (HP:0000189)1.68319028
157Poor coordination (HP:0002370)1.67270809
158Aplasia/Hypoplasia of the tongue (HP:0010295)1.66867973
159Medial flaring of the eyebrow (HP:0010747)1.64918879
160Progressive cerebellar ataxia (HP:0002073)1.64110910

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.43237003
2CDC74.23020218
3BRD43.70261320
4NEK22.76531066
5WEE12.64462606
6SRPK12.63127448
7FLT32.48039126
8ACVR1B2.19716134
9INSRR2.14000958
10TTK2.09441226
11MAP3K102.09326904
12FGFR32.07081987
13PASK1.96031464
14ATR1.94303864
15NEK11.91636165
16ERBB31.84636492
17OBSCN1.84075346
18PLK41.78827452
19ZAK1.76783938
20MKNK11.74508885
21PLK11.73534122
22PLK31.70949620
23PKN21.70103379
24EEF2K1.59783432
25STK241.57764346
26DYRK31.57164907
27CHEK21.53204781
28CHEK11.52286472
29BRSK21.51135570
30TRPM71.49638465
31STK41.44949399
32NTRK31.41766439
33MKNK21.38200272
34SCYL21.37638431
35WNK11.36537715
36RPS6KB21.35057214
37CDK71.33918748
38BMPR1B1.33163924
39CDK61.31869280
40EIF2AK31.31400074
41NUAK11.31289475
42ATM1.30047623
43AURKB1.29444478
44STK391.27250039
45CDK41.26295336
46PNCK1.20050866
47LATS11.19028854
48EIF2AK11.18686516
49STK38L1.16623383
50CSF1R1.16173931
51CASK1.13655802
52NLK1.04818646
53MAP3K21.02240488
54CDK21.01012341
55KIT0.99248397
56PIM10.98904050
57SIK20.97162244
58MAP3K60.96553945
59MAPK130.96153853
60KSR10.95249956
61PHKG20.93779536
62PHKG10.93779536
63TGFBR10.92694353
64WNK30.91837428
65EPHA20.90868170
66PIK3CG0.89709378
67SGK20.88360573
68MAP2K30.88251656
69STK30.87468637
70DMPK0.86116662
71TSSK60.85885177
72NEK60.84838655
73MELK0.84397510
74MST40.83986301
75TNIK0.83365555
76MAP3K90.83295029
77AKT30.81917578
78CDK10.81740545
79FRK0.80985762
80JAK30.80555038
81MTOR0.79404099
82VRK10.78762974
83WNK40.78435596
84RPS6KA40.78333069
85SGK10.78089335
86MAP3K80.77892233
87PAK40.75742004
88YES10.75697063
89CAMK1D0.74157122
90BMPR20.73742371
91NEK90.73609837
92PIK3CA0.73115025
93SGK2230.72462671
94SGK4940.72462671
95CDK90.70718910
96CAMK1G0.70643369
97FGFR10.69690961
98CHUK0.68399166
99TAOK30.68158020
100CAMKK20.67189625
101PRKAA20.66121421
102RIPK10.65286719
103MAP2K40.64414685
104IRAK10.63304018
105BUB10.62913263
106PINK10.62374947
107PRKDC0.62195587
108AKT20.62109773
109MAPK100.61607379
110NTRK20.61408953
111ALK0.61355092
112CDK80.61302939
113RPS6KB10.59027730
114SGK30.58719855
115TLK10.58521601
116PLK20.57813539
117STK110.57264191
118MAP3K40.56994873
119PTK2B0.56466446
120PRKAA10.55330065
121MAPK140.54661524
122CCNB10.54586227
123TEC0.52333011
124MAPK110.52130033
125CSNK1D0.51993212
126BRSK10.51772522
127PDK30.51056575
128PDK40.51056575
129AKT10.50715079
130STK100.50256721
131CDK30.50006283
132PAK30.49235340
133TTN0.47811334
134DAPK10.46443579
135MAP3K70.46266076
136MAP3K130.46110269
137RET0.46049073
138EIF2AK20.46028939
139AURKA0.44516565
140CAMK40.43767123
141MAPK120.43740586
142PRKCI0.42673433
143GSK3B0.42353712
144RPS6KC10.40055863
145RPS6KL10.40055863
146MARK30.39779708
147FGFR20.39246826
148TAF10.38695345
149MAP4K10.37957232
150RPS6KA50.36636341
151SIK30.34767924
152CSNK1E0.34663653
153RPS6KA60.33021519

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.75605174
2DNA replication_Homo sapiens_hsa030303.74923787
3Cell cycle_Homo sapiens_hsa041103.13216768
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10071189
5RNA transport_Homo sapiens_hsa030132.86043885
6Homologous recombination_Homo sapiens_hsa034402.64203840
7Spliceosome_Homo sapiens_hsa030402.59052562
8mRNA surveillance pathway_Homo sapiens_hsa030152.55253253
9* Fanconi anemia pathway_Homo sapiens_hsa034602.54149273
10Base excision repair_Homo sapiens_hsa034102.53631297
11Nucleotide excision repair_Homo sapiens_hsa034202.41478949
12One carbon pool by folate_Homo sapiens_hsa006702.39867898
13RNA degradation_Homo sapiens_hsa030182.32656596
14Non-homologous end-joining_Homo sapiens_hsa034502.24768930
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21358049
16Systemic lupus erythematosus_Homo sapiens_hsa053222.13286318
17Basal transcription factors_Homo sapiens_hsa030221.91860753
18p53 signaling pathway_Homo sapiens_hsa041151.68324475
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53268450
20MicroRNAs in cancer_Homo sapiens_hsa052061.50466578
21Transcriptional misregulation in cancer_Homo sapiens_hsa052021.47894047
22Oocyte meiosis_Homo sapiens_hsa041141.45582186
23Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45299781
24Viral carcinogenesis_Homo sapiens_hsa052031.41516376
25Lysine degradation_Homo sapiens_hsa003101.40256659
26ABC transporters_Homo sapiens_hsa020101.36696182
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.30548354
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25903207
29Alcoholism_Homo sapiens_hsa050341.24605219
30Herpes simplex infection_Homo sapiens_hsa051681.21479983
31mTOR signaling pathway_Homo sapiens_hsa041501.13499145
32Central carbon metabolism in cancer_Homo sapiens_hsa052301.11845465
33Olfactory transduction_Homo sapiens_hsa047401.08647140
34Chronic myeloid leukemia_Homo sapiens_hsa052201.08018742
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07056153
36HTLV-I infection_Homo sapiens_hsa051661.06113324
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02533328
38Jak-STAT signaling pathway_Homo sapiens_hsa046301.02115088
39Colorectal cancer_Homo sapiens_hsa052101.01582318
40Notch signaling pathway_Homo sapiens_hsa043300.97427472
41Non-small cell lung cancer_Homo sapiens_hsa052230.95143616
42Butanoate metabolism_Homo sapiens_hsa006500.94897924
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94211485
44Choline metabolism in cancer_Homo sapiens_hsa052310.94027785
45RNA polymerase_Homo sapiens_hsa030200.93934468
46Adherens junction_Homo sapiens_hsa045200.93763749
47Epstein-Barr virus infection_Homo sapiens_hsa051690.91731467
48Small cell lung cancer_Homo sapiens_hsa052220.91471138
49Renin secretion_Homo sapiens_hsa049240.90694228
50TGF-beta signaling pathway_Homo sapiens_hsa043500.90158491
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87811666
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.87034617
53Pyrimidine metabolism_Homo sapiens_hsa002400.86624468
54Insulin resistance_Homo sapiens_hsa049310.85994709
55Endometrial cancer_Homo sapiens_hsa052130.85650581
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84988513
57Ether lipid metabolism_Homo sapiens_hsa005650.84263819
58Regulation of autophagy_Homo sapiens_hsa041400.82434090
59Ovarian steroidogenesis_Homo sapiens_hsa049130.81994235
60Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81524499
61FoxO signaling pathway_Homo sapiens_hsa040680.81119574
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.80178562
63Thyroid cancer_Homo sapiens_hsa052160.78723366
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.74889059
65Long-term depression_Homo sapiens_hsa047300.74404222
66Acute myeloid leukemia_Homo sapiens_hsa052210.74325044
67Insulin secretion_Homo sapiens_hsa049110.73359284
68B cell receptor signaling pathway_Homo sapiens_hsa046620.72777936
69Prostate cancer_Homo sapiens_hsa052150.71735378
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71569650
71Pancreatic cancer_Homo sapiens_hsa052120.71326410
72Glioma_Homo sapiens_hsa052140.70882083
73GnRH signaling pathway_Homo sapiens_hsa049120.69505480
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69485156
75Hepatitis B_Homo sapiens_hsa051610.67471534
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67434263
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67025156
78Selenocompound metabolism_Homo sapiens_hsa004500.66739828
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.66065384
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65981872
81Hippo signaling pathway_Homo sapiens_hsa043900.64503034
82Propanoate metabolism_Homo sapiens_hsa006400.64319427
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63948571
84Calcium signaling pathway_Homo sapiens_hsa040200.63839645
85Oxytocin signaling pathway_Homo sapiens_hsa049210.63753134
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61590792
87HIF-1 signaling pathway_Homo sapiens_hsa040660.61055871
88Purine metabolism_Homo sapiens_hsa002300.60359034
89Glucagon signaling pathway_Homo sapiens_hsa049220.57091610
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56859759
91Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56363349
92Dilated cardiomyopathy_Homo sapiens_hsa054140.56049679
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.55711865
94Fatty acid biosynthesis_Homo sapiens_hsa000610.55126963
95Basal cell carcinoma_Homo sapiens_hsa052170.55052061
96Proteoglycans in cancer_Homo sapiens_hsa052050.54996820
97Pathways in cancer_Homo sapiens_hsa052000.53409527
98Inositol phosphate metabolism_Homo sapiens_hsa005620.51629648
99Influenza A_Homo sapiens_hsa051640.50745517
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49959222
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49633805
102Thyroid hormone synthesis_Homo sapiens_hsa049180.48817409
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48508753
104Amphetamine addiction_Homo sapiens_hsa050310.48443535
105cAMP signaling pathway_Homo sapiens_hsa040240.48382456
106Wnt signaling pathway_Homo sapiens_hsa043100.48091600
107Circadian rhythm_Homo sapiens_hsa047100.47121627
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46957254
109Type II diabetes mellitus_Homo sapiens_hsa049300.46293308
110Long-term potentiation_Homo sapiens_hsa047200.45623028
111Apoptosis_Homo sapiens_hsa042100.44558432
112T cell receptor signaling pathway_Homo sapiens_hsa046600.44145694
113Melanoma_Homo sapiens_hsa052180.39862790
114Dorso-ventral axis formation_Homo sapiens_hsa043200.38538153
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.38214363
116ErbB signaling pathway_Homo sapiens_hsa040120.37416650
117Measles_Homo sapiens_hsa051620.36505141
118Estrogen signaling pathway_Homo sapiens_hsa049150.35478252
119Antigen processing and presentation_Homo sapiens_hsa046120.34080484
120Renal cell carcinoma_Homo sapiens_hsa052110.33639656
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33252285
122MAPK signaling pathway_Homo sapiens_hsa040100.33227971
123Legionellosis_Homo sapiens_hsa051340.33051556
124Focal adhesion_Homo sapiens_hsa045100.32711218
125Platelet activation_Homo sapiens_hsa046110.31371309
126Insulin signaling pathway_Homo sapiens_hsa049100.31228482
127Prolactin signaling pathway_Homo sapiens_hsa049170.31071184
128Tight junction_Homo sapiens_hsa045300.30601908
129AMPK signaling pathway_Homo sapiens_hsa041520.29656346
130Leishmaniasis_Homo sapiens_hsa051400.28290511
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26824925
132Viral myocarditis_Homo sapiens_hsa054160.25269053
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23936747
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23935390
135Biosynthesis of amino acids_Homo sapiens_hsa012300.23014053
136Hedgehog signaling pathway_Homo sapiens_hsa043400.22991440
137Bladder cancer_Homo sapiens_hsa052190.22406239
138Rap1 signaling pathway_Homo sapiens_hsa040150.22205966
139Toxoplasmosis_Homo sapiens_hsa051450.21555951

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