REV3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)3.78758945
2mitotic sister chromatid cohesion (GO:0007064)3.76360098
3establishment of protein localization to Golgi (GO:0072600)3.64027201
4regulation of pigment cell differentiation (GO:0050932)3.60592685
5establishment of nucleus localization (GO:0040023)3.58142387
6cytoplasmic mRNA processing body assembly (GO:0033962)3.57536603
7regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.44835633
8positive regulation of developmental pigmentation (GO:0048087)3.44760375
9response to pheromone (GO:0019236)3.42672999
10innervation (GO:0060384)3.38661301
11central nervous system projection neuron axonogenesis (GO:0021952)3.29586051
12histone H3-K4 trimethylation (GO:0080182)3.26526806
13presynaptic membrane assembly (GO:0097105)3.15686703
14phospholipid translocation (GO:0045332)3.14921027
15lipid translocation (GO:0034204)3.14921027
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.14192311
17nucleus localization (GO:0051647)3.13266021
18regulation of establishment of cell polarity (GO:2000114)3.08306580
19protein K11-linked deubiquitination (GO:0035871)3.01590103
20retinal rod cell development (GO:0046548)3.00957416
21dendrite morphogenesis (GO:0048813)3.00560634
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00059119
23negative regulation of neurotransmitter transport (GO:0051589)2.98205583
24regulation of establishment or maintenance of cell polarity (GO:0032878)2.97786233
25pre-miRNA processing (GO:0031054)2.94022623
26interkinetic nuclear migration (GO:0022027)2.91225517
27regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90518085
28stress granule assembly (GO:0034063)2.89620120
29neuron cell-cell adhesion (GO:0007158)2.87937050
30regulation of RNA export from nucleus (GO:0046831)2.87335872
31axonal fasciculation (GO:0007413)2.86500818
32appendage development (GO:0048736)2.84466489
33limb development (GO:0060173)2.84466489
34pericardium development (GO:0060039)2.82927839
35neural tube formation (GO:0001841)2.82423966
36head development (GO:0060322)2.79494971
37gonadal mesoderm development (GO:0007506)2.79374632
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.78847802
39fibroblast migration (GO:0010761)2.78768290
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.78223696
41negative regulation of translation, ncRNA-mediated (GO:0040033)2.78223696
42regulation of translation, ncRNA-mediated (GO:0045974)2.78223696
43positive regulation of synapse maturation (GO:0090129)2.76788512
44pyrimidine nucleobase catabolic process (GO:0006208)2.75978088
45positive regulation of dendritic spine morphogenesis (GO:0061003)2.75261322
46lateral sprouting from an epithelium (GO:0060601)2.73051655
47microtubule anchoring (GO:0034453)2.70746707
48locomotory exploration behavior (GO:0035641)2.70479525
49nuclear pore complex assembly (GO:0051292)2.69328643
50postsynaptic membrane organization (GO:0001941)2.66704669
51peptidyl-lysine trimethylation (GO:0018023)2.63136185
52negative regulation of neurotransmitter secretion (GO:0046929)2.62022016
53neuronal stem cell maintenance (GO:0097150)2.61843905
54regulation of hippo signaling (GO:0035330)2.61517056
55protein localization to synapse (GO:0035418)2.61457151
56dendritic spine morphogenesis (GO:0060997)2.60662071
57snRNA transcription (GO:0009301)2.60441440
58histone H3-K9 demethylation (GO:0033169)2.60402383
59positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.58443388
60regulation of sarcomere organization (GO:0060297)2.57847821
61cerebellar Purkinje cell differentiation (GO:0021702)2.56047794
62inner ear receptor cell development (GO:0060119)2.55756278
63gamma-aminobutyric acid transport (GO:0015812)2.55688565
64histone H3-K4 methylation (GO:0051568)2.55225760
65histone lysine methylation (GO:0034968)2.55015461
66negative regulation of protein localization to cell surface (GO:2000009)2.54940493
67hippo signaling (GO:0035329)2.54890529
68central nervous system neuron axonogenesis (GO:0021955)2.53191598
69presynaptic membrane organization (GO:0097090)2.53008713
70histone H3-K9 methylation (GO:0051567)2.52474162
71neuron recognition (GO:0008038)2.52279480
72insulin-like growth factor receptor signaling pathway (GO:0048009)2.51788870
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50750170
74retinal cone cell development (GO:0046549)2.48211162
75NLS-bearing protein import into nucleus (GO:0006607)2.47835842
76homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.47829533
77prenylation (GO:0097354)2.47805749
78protein prenylation (GO:0018342)2.47805749
79regulation of nucleobase-containing compound transport (GO:0032239)2.46677493
80tachykinin receptor signaling pathway (GO:0007217)2.45485014
81dermatan sulfate biosynthetic process (GO:0030208)2.44863967
82exploration behavior (GO:0035640)2.44754885
83embryonic retina morphogenesis in camera-type eye (GO:0060059)2.44604923
84axon extension (GO:0048675)2.44411022
85cell migration in hindbrain (GO:0021535)2.43613706
86indole-containing compound catabolic process (GO:0042436)2.41741809
87indolalkylamine catabolic process (GO:0046218)2.41741809
88tryptophan catabolic process (GO:0006569)2.41741809
89regulation of axon extension involved in axon guidance (GO:0048841)2.40881872
90mRNA splice site selection (GO:0006376)2.40834120
91indolalkylamine metabolic process (GO:0006586)2.39760569
92protein K48-linked deubiquitination (GO:0071108)2.39357703
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.39056694
94regulation of axon guidance (GO:1902667)2.38749815
95phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.37821567
96detection of light stimulus involved in sensory perception (GO:0050962)2.37803503
97detection of light stimulus involved in visual perception (GO:0050908)2.37803503
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.37089248
99axon extension involved in axon guidance (GO:0048846)2.37089248
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.36510818
101histone lysine demethylation (GO:0070076)2.36311215
102neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.36053961
103cellular response to sterol (GO:0036315)2.33663481
104positive regulation of cardiac muscle hypertrophy (GO:0010613)2.33358936
105positive regulation of muscle hypertrophy (GO:0014742)2.33358936
106cilium organization (GO:0044782)2.33085786
107regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32812545
108cilium assembly (GO:0042384)2.32229511
109smooth muscle contraction (GO:0006939)2.31556856
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31552709
111RNA localization (GO:0006403)2.30454306
112negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.30204024
113reflex (GO:0060004)2.30104409
114dorsal/ventral axis specification (GO:0009950)2.29918832
115smooth muscle tissue development (GO:0048745)2.29198080
116positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.29175383
117prostate gland growth (GO:0060736)2.28521147
118cilium morphogenesis (GO:0060271)2.28096892
119heart morphogenesis (GO:0003007)2.28024888
120membrane depolarization during action potential (GO:0086010)2.26547140
121righting reflex (GO:0060013)2.26051538
122somite development (GO:0061053)2.25810700
123spliceosomal tri-snRNP complex assembly (GO:0000244)2.25798094
124negative regulation of sodium ion transport (GO:0010766)2.25776127
125negative regulation of catenin import into nucleus (GO:0035414)2.25600970
126sympathetic nervous system development (GO:0048485)2.24901887
127atrial cardiac muscle cell action potential (GO:0086014)2.24878764
128ectodermal placode formation (GO:0060788)2.23482928
129protein localization to Golgi apparatus (GO:0034067)2.23275469
130photoreceptor cell maintenance (GO:0045494)2.23145125
131regulation of non-canonical Wnt signaling pathway (GO:2000050)2.22970272
132C4-dicarboxylate transport (GO:0015740)2.21972038
133clathrin coat assembly (GO:0048268)2.21663447
134centrosome duplication (GO:0051298)2.21619690
135genitalia morphogenesis (GO:0035112)2.20901712
136cellular response to ethanol (GO:0071361)2.20650426
137gastrulation with mouth forming second (GO:0001702)2.20332055
138regulation of action potential (GO:0098900)2.19721276
139hindbrain development (GO:0030902)2.19698012
140cyclic nucleotide catabolic process (GO:0009214)2.19620128
141retrograde transport, vesicle recycling within Golgi (GO:0000301)2.19569876
142negative regulation of histone methylation (GO:0031061)2.19289650
143negative regulation of axon guidance (GO:1902668)2.19101044
144intraciliary transport (GO:0042073)2.19054436
145neurotransmitter-gated ion channel clustering (GO:0072578)2.18397064
146negative regulation of axon extension involved in axon guidance (GO:0048843)2.18288078
147regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.17853461
148startle response (GO:0001964)2.17703534
149apical protein localization (GO:0045176)2.17649226
150positive regulation of glycolytic process (GO:0045821)2.17534943
151histone demethylation (GO:0016577)2.16547511
152interleukin-6-mediated signaling pathway (GO:0070102)2.16062205
153monoubiquitinated protein deubiquitination (GO:0035520)2.15777917
154calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.15648113
155positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.15631771
156auditory behavior (GO:0031223)2.15146073
157neuronal action potential (GO:0019228)2.15096757
158histone methylation (GO:0016571)2.14694461
159histone H4-K16 acetylation (GO:0043984)2.14548827
160Golgi to endosome transport (GO:0006895)2.14307198
161detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.14275082
162hippocampus development (GO:0021766)2.14142098
163vocalization behavior (GO:0071625)2.14077562
164cellular component assembly involved in morphogenesis (GO:0010927)2.13974754
165peptidyl-lysine methylation (GO:0018022)2.13765098
166neuronal action potential propagation (GO:0019227)2.13190759
167dermatan sulfate metabolic process (GO:0030205)2.12592539
168nuclear pore organization (GO:0006999)2.12256469
169histone H3-K9 modification (GO:0061647)2.12109569
170cilium or flagellum-dependent cell motility (GO:0001539)2.11016548
171hindlimb morphogenesis (GO:0035137)2.10845254
172glial cell proliferation (GO:0014009)2.10714056
173histone H3-K36 demethylation (GO:0070544)2.09718651
174paraxial mesoderm development (GO:0048339)2.08993843
175protein targeting to Golgi (GO:0000042)2.08932130
176mesenchymal-epithelial cell signaling (GO:0060638)2.08878272
177regulation of synaptic vesicle exocytosis (GO:2000300)2.08369334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.28710040
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.70509530
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.09089543
4GBX2_23144817_ChIP-Seq_PC3_Human2.96715755
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82002753
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.71652260
7* SALL1_21062744_ChIP-ChIP_HESCs_Human2.68945960
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52189719
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37843448
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.20256820
11AR_21572438_ChIP-Seq_LNCaP_Human2.17101972
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.00787066
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00204307
14IGF1R_20145208_ChIP-Seq_DFB_Human1.96336798
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87458660
16VDR_22108803_ChIP-Seq_LS180_Human1.85369176
17FUS_26573619_Chip-Seq_HEK293_Human1.82216921
18FLI1_27457419_Chip-Seq_LIVER_Mouse1.82061650
19POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81687110
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72660309
21ZNF274_21170338_ChIP-Seq_K562_Hela1.72540229
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.71549051
23ER_23166858_ChIP-Seq_MCF-7_Human1.70221291
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69983012
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69367940
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.66341045
27TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65559509
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.64924490
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62803964
30DROSHA_22980978_ChIP-Seq_HELA_Human1.60564494
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.59764758
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58951962
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58325190
34* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58174389
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56209304
36RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55319887
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55058293
38UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54089944
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53637896
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53637896
41TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52822024
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52822024
43TP63_19390658_ChIP-ChIP_HaCaT_Human1.52323852
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52092571
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.52019213
46* STAT3_23295773_ChIP-Seq_U87_Human1.51962931
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.50644687
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50387304
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.47452737
50YAP1_20516196_ChIP-Seq_MESCs_Mouse1.47146274
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46785888
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.46539443
53TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45351124
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.44249267
55CBP_20019798_ChIP-Seq_JUKART_Human1.43528313
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43528313
57* EZH2_27294783_Chip-Seq_NPCs_Mouse1.43343799
58ARNT_22903824_ChIP-Seq_MCF-7_Human1.42983329
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41647511
60DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41340240
61P300_19829295_ChIP-Seq_ESCs_Human1.40301068
62AHR_22903824_ChIP-Seq_MCF-7_Human1.38108614
63* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38068069
64* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38068069
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37896536
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37654202
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.36637443
68* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36472398
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36222702
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.36059460
71AR_19668381_ChIP-Seq_PC3_Human1.35027401
72ISL1_27105846_Chip-Seq_CPCs_Mouse1.34020372
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34018954
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33688445
75* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32937421
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31475698
77* TCF4_23295773_ChIP-Seq_U87_Human1.31136094
78* TP53_18474530_ChIP-ChIP_U2OS_Human1.30327290
79REST_21632747_ChIP-Seq_MESCs_Mouse1.29978721
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29734795
81* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29683024
82* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29538032
83* FLI1_21867929_ChIP-Seq_TH2_Mouse1.28410535
84ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27986456
85TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26531593
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26435640
87TBX3_20139965_ChIP-Seq_MESCs_Mouse1.25875960
88FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24562926
89EWS_26573619_Chip-Seq_HEK293_Human1.23034330
90TAF15_26573619_Chip-Seq_HEK293_Human1.22696146
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.21888103
92KDM2B_26808549_Chip-Seq_REH_Human1.21827954
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21600279
94E2F1_18555785_Chip-Seq_ESCs_Mouse1.21512561
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.21185927
96P53_22387025_ChIP-Seq_ESCs_Mouse1.20492704
97RNF2_27304074_Chip-Seq_NSC_Mouse1.19929438
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19656600
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.19551653
100AR_25329375_ChIP-Seq_VCAP_Human1.19423563
101TCF4_22108803_ChIP-Seq_LS180_Human1.18991541
102TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18924596
103* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18859667
104TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18270378
105TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18133827
106SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.17788786
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17588510
108* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16674020
109PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16243632
110CJUN_26792858_Chip-Seq_BT549_Human1.15983329
111TP53_16413492_ChIP-PET_HCT116_Human1.15587503
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.15385477
113* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14566635
114* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14050162
115* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13657198
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13529425
117CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11949172
118SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11729705
119CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11201765
120BCAT_22108803_ChIP-Seq_LS180_Human1.11129842
121SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10543009
122* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10394842
123* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10351134
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10035277
125EP300_21415370_ChIP-Seq_HL-1_Mouse1.09969642
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09250962
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.09195725
128* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08490822
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08478516
130CMYC_18555785_Chip-Seq_ESCs_Mouse1.08213103
131BRD4_25478319_ChIP-Seq_HGPS_Human1.06491685
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.06105441
133RUNX2_22187159_ChIP-Seq_PCA_Human1.05527461
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05106521
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04960061
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04954780
137EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04432579
138ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02998877
139SMAD3_21741376_ChIP-Seq_ESCs_Human1.02571948
140RING1B_27294783_Chip-Seq_ESCs_Mouse1.02157291
141CDX2_22108803_ChIP-Seq_LS180_Human1.02025887
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00874732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.35454435
2MP0008057_abnormal_DNA_replication2.89584638
3MP0003787_abnormal_imprinting2.83518277
4MP0010386_abnormal_urinary_bladder2.69476947
5MP0003121_genomic_imprinting2.52077392
6MP0003122_maternal_imprinting2.48727687
7MP0005171_absent_coat_pigmentation2.32488356
8MP0006072_abnormal_retinal_apoptosis2.21547497
9MP0000778_abnormal_nervous_system2.16318254
10MP0003890_abnormal_embryonic-extraembry2.08934077
11MP0005551_abnormal_eye_electrophysiolog2.08021110
12MP0005187_abnormal_penis_morphology2.02990168
13MP0009780_abnormal_chondrocyte_physiolo1.91726828
14MP0001299_abnormal_eye_distance/1.90129922
15MP0005248_abnormal_Harderian_gland1.89961637
16MP0005174_abnormal_tail_pigmentation1.83900491
17MP0006054_spinal_hemorrhage1.82140121
18MP0000631_abnormal_neuroendocrine_gland1.76568246
19MP0004859_abnormal_synaptic_plasticity1.73960123
20MP0005076_abnormal_cell_differentiation1.73924467
21MP0000537_abnormal_urethra_morphology1.70376156
22MP0002653_abnormal_ependyma_morphology1.67552892
23MP0002638_abnormal_pupillary_reflex1.66124150
24MP0008438_abnormal_cutaneous_collagen1.65602054
25MP0002184_abnormal_innervation1.58978668
26MP0003385_abnormal_body_wall1.53224637
27MP0004145_abnormal_muscle_electrophysio1.52492722
28MP0008877_abnormal_DNA_methylation1.52084214
29MP0003942_abnormal_urinary_system1.51978128
30MP0001968_abnormal_touch/_nociception1.51213481
31* MP0003935_abnormal_craniofacial_develop1.51162494
32MP0001984_abnormal_olfaction1.50674721
33MP0005253_abnormal_eye_physiology1.50279752
34MP0003195_calcinosis1.49800524
35MP0000534_abnormal_ureter_morphology1.49618487
36MP0003045_fibrosis1.47722639
37MP0002102_abnormal_ear_morphology1.45698644
38MP0000383_abnormal_hair_follicle1.45360489
39MP0000428_abnormal_craniofacial_morphol1.45198652
40MP0002938_white_spotting1.44703184
41MP0002735_abnormal_chemical_nociception1.43845482
42* MP0003861_abnormal_nervous_system1.43645124
43MP0001293_anophthalmia1.42171104
44MP0003937_abnormal_limbs/digits/tail_de1.41740942
45MP0005423_abnormal_somatic_nervous1.41638642
46MP0004270_analgesia1.41410923
47MP0003755_abnormal_palate_morphology1.41198362
48MP0002736_abnormal_nociception_after1.40958161
49MP0004924_abnormal_behavior1.40572769
50MP0005386_behavior/neurological_phenoty1.40572769
51MP0009250_abnormal_appendicular_skeleto1.39587171
52MP0004233_abnormal_muscle_weight1.39076824
53MP0005275_abnormal_skin_tensile1.38183717
54MP0003115_abnormal_respiratory_system1.37722764
55MP0003635_abnormal_synaptic_transmissio1.37349243
56MP0000372_irregular_coat_pigmentation1.35734209
57MP0008789_abnormal_olfactory_epithelium1.35113051
58MP0002160_abnormal_reproductive_system1.32848703
59MP0003950_abnormal_plasma_membrane1.30892886
60MP0004134_abnormal_chest_morphology1.29647911
61MP0003646_muscle_fatigue1.29063785
62MP0004043_abnormal_pH_regulation1.28117714
63MP0002272_abnormal_nervous_system1.27951044
64MP0002837_dystrophic_cardiac_calcinosis1.27749354
65MP0002168_other_aberrant_phenotype1.27175270
66MP0002116_abnormal_craniofacial_bone1.26971952
67MP0005394_taste/olfaction_phenotype1.24961918
68MP0005499_abnormal_olfactory_system1.24961918
69MP0002557_abnormal_social/conspecific_i1.23549386
70MP0001501_abnormal_sleep_pattern1.22957164
71MP0002063_abnormal_learning/memory/cond1.22826084
72MP0003119_abnormal_digestive_system1.22755635
73MP0009703_decreased_birth_body1.20547771
74MP0005503_abnormal_tendon_morphology1.19804936
75MP0002233_abnormal_nose_morphology1.19229042
76MP0002152_abnormal_brain_morphology1.16832375
77MP0005391_vision/eye_phenotype1.16156175
78MP0001958_emphysema1.15546845
79MP0002108_abnormal_muscle_morphology1.13386513
80MP0004885_abnormal_endolymph1.13167727
81MP0002009_preneoplasia1.13161268
82MP0002882_abnormal_neuron_morphology1.13090835
83MP0009745_abnormal_behavioral_response1.12835904
84MP0005645_abnormal_hypothalamus_physiol1.11997817
85MP0000049_abnormal_middle_ear1.10885883
86MP0010030_abnormal_orbit_morphology1.10579706
87MP0003136_yellow_coat_color1.10302303
88MP0000538_abnormal_urinary_bladder1.09818757
89MP0000955_abnormal_spinal_cord1.09144673
90MP0003123_paternal_imprinting1.08517483
91MP0001502_abnormal_circadian_rhythm1.07706914
92MP0000015_abnormal_ear_pigmentation1.07061094
93MP0003283_abnormal_digestive_organ1.05052404
94* MP0002084_abnormal_developmental_patter1.04550104
95MP0002697_abnormal_eye_size1.04441603
96MP0005195_abnormal_posterior_eye1.02859620
97MP0000733_abnormal_muscle_development1.02818761
98MP0004197_abnormal_fetal_growth/weight/1.02615483
99MP0000432_abnormal_head_morphology1.02356402
100MP0003633_abnormal_nervous_system1.02349776
101MP0004811_abnormal_neuron_physiology1.01559907
102MP0008961_abnormal_basal_metabolism1.00851273
103MP0001486_abnormal_startle_reflex1.00543052
104MP0004215_abnormal_myocardial_fiber0.99258514
105MP0003868_abnormal_feces_composition0.98995744
106MP0004142_abnormal_muscle_tone0.97898590
107MP0002095_abnormal_skin_pigmentation0.97229371
108MP0000013_abnormal_adipose_tissue0.96366117
109MP0002064_seizures0.96241394
110MP0002081_perinatal_lethality0.95932115
111MP0002234_abnormal_pharynx_morphology0.95742692
112MP0002751_abnormal_autonomic_nervous0.95286119
113MP0002734_abnormal_mechanical_nocicepti0.94655442
114MP0002928_abnormal_bile_duct0.93433378
115MP0001286_abnormal_eye_development0.92049750
116MP0009672_abnormal_birth_weight0.91867829
117MP0002109_abnormal_limb_morphology0.91864985
118MP0005389_reproductive_system_phenotype0.90839279
119MP0000371_diluted_coat_color0.90455672
120MP0002752_abnormal_somatic_nervous0.89893085
121MP0002177_abnormal_outer_ear0.89635743
122MP0004130_abnormal_muscle_cell0.89144091
123MP0000566_synostosis0.88564221
124MP0000462_abnormal_digestive_system0.88303619
125MP0002572_abnormal_emotion/affect_behav0.88191117
126MP0005646_abnormal_pituitary_gland0.87414432
127MP0010678_abnormal_skin_adnexa0.87134815
128MP0002067_abnormal_sensory_capabilities0.87003294
129MP0003880_abnormal_central_pattern0.86394477
130* MP0002085_abnormal_embryonic_tissue0.86356921
131MP0005367_renal/urinary_system_phenotyp0.86224024
132MP0000516_abnormal_urinary_system0.86224024
133MP0001970_abnormal_pain_threshold0.85371632
134MP0001177_atelectasis0.85208804
135MP0002092_abnormal_eye_morphology0.85056204
136MP0005220_abnormal_exocrine_pancreas0.84453945
137MP0001188_hyperpigmentation0.84372710
138MP0002249_abnormal_larynx_morphology0.81555705
139MP0002114_abnormal_axial_skeleton0.80813707
140MP0009046_muscle_twitch0.79592778
141MP0000427_abnormal_hair_cycle0.79514578
142MP0010352_gastrointestinal_tract_polyps0.79394059
143MP0003941_abnormal_skin_development0.78311868
144MP0002932_abnormal_joint_morphology0.77909189
145MP0003631_nervous_system_phenotype0.77071305
146MP0003698_abnormal_male_reproductive0.76970346
147MP0000639_abnormal_adrenal_gland0.75292553
148MP0006276_abnormal_autonomic_nervous0.75234597
149MP0005623_abnormal_meninges_morphology0.74864214
150MP0004272_abnormal_basement_membrane0.74190947

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.15000325
2Short 4th metacarpal (HP:0010044)3.84329620
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.84329620
4Gaze-evoked nystagmus (HP:0000640)3.45344557
5Abnormality of the ischium (HP:0003174)3.29020023
6Protruding tongue (HP:0010808)3.28315841
7Hypoplastic ischia (HP:0003175)3.15576407
8Midline defect of the nose (HP:0004122)3.12572388
9Volvulus (HP:0002580)3.05382632
10Febrile seizures (HP:0002373)3.04598206
11Genetic anticipation (HP:0003743)2.87640041
12Congenital stationary night blindness (HP:0007642)2.85349734
13Fair hair (HP:0002286)2.83075354
14Papillary thyroid carcinoma (HP:0002895)2.81903311
15Macroorchidism (HP:0000053)2.81448395
16Abnormality of the 4th metacarpal (HP:0010012)2.80891913
17Abnormality of the renal cortex (HP:0011035)2.80857120
18Aplasia/Hypoplasia of the tibia (HP:0005772)2.78155969
19Pancreatic cysts (HP:0001737)2.75374267
20Pancreatic fibrosis (HP:0100732)2.70064632
21Renovascular hypertension (HP:0100817)2.61049721
22True hermaphroditism (HP:0010459)2.60083230
23Nephronophthisis (HP:0000090)2.59228302
24Trigonocephaly (HP:0000243)2.55857148
25Renal cortical cysts (HP:0000803)2.53080684
26Aqueductal stenosis (HP:0002410)2.48565600
27Tubulointerstitial nephritis (HP:0001970)2.47383301
28Abnormality of the renal medulla (HP:0100957)2.44568027
29Narrow palate (HP:0000189)2.40805591
30Hepatoblastoma (HP:0002884)2.39835550
31Molar tooth sign on MRI (HP:0002419)2.39191713
32Abnormality of midbrain morphology (HP:0002418)2.39191713
33Medial flaring of the eyebrow (HP:0010747)2.36543214
34Broad-based gait (HP:0002136)2.33464627
35Heterotopia (HP:0002282)2.29185516
36Blue irides (HP:0000635)2.29127162
37Focal seizures (HP:0007359)2.28097746
38Drooling (HP:0002307)2.22433734
39Excessive salivation (HP:0003781)2.22433734
40Obsessive-compulsive behavior (HP:0000722)2.21682098
41Generalized hypopigmentation of hair (HP:0011358)2.19159222
42Genital tract atresia (HP:0001827)2.17094627
43Progressive cerebellar ataxia (HP:0002073)2.16182312
44Abnormality of the fingertips (HP:0001211)2.16112223
45Truncal obesity (HP:0001956)2.15533869
46Intestinal atresia (HP:0011100)2.15348325
47Hemiparesis (HP:0001269)2.11737858
48Elfin facies (HP:0004428)2.09709506
49Shallow orbits (HP:0000586)2.09341349
50Short foot (HP:0001773)2.09085049
51Aortic aneurysm (HP:0004942)2.08281175
52Tented upper lip vermilion (HP:0010804)2.08107595
53Anteriorly placed anus (HP:0001545)2.07381197
54Congenital primary aphakia (HP:0007707)2.06132181
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.05687434
56Chorioretinal atrophy (HP:0000533)2.05250200
57Congenital sensorineural hearing impairment (HP:0008527)2.04998860
58Vaginal atresia (HP:0000148)2.04961533
59Focal motor seizures (HP:0011153)2.04603203
60Renal duplication (HP:0000075)2.03849221
61Poor coordination (HP:0002370)2.03394262
62Overgrowth (HP:0001548)2.02311461
63Neoplasm of the heart (HP:0100544)1.99028336
64Increased nuchal translucency (HP:0010880)1.96670460
65Neoplasm of the adrenal cortex (HP:0100641)1.96639851
66Abnormality of the nasal septum (HP:0000419)1.96087678
67Thyroiditis (HP:0100646)1.94968078
68Hyperacusis (HP:0010780)1.93641446
69Abnormality of the diencephalon (HP:0010662)1.92861452
70Short chin (HP:0000331)1.91957116
71Dialeptic seizures (HP:0011146)1.89888788
72Limited hip movement (HP:0008800)1.89239957
73Hypoplastic iliac wings (HP:0002866)1.89083021
74Cystic liver disease (HP:0006706)1.88755564
75Nephrogenic diabetes insipidus (HP:0009806)1.88695273
76Bulbous nose (HP:0000414)1.88627947
77Sacral dimple (HP:0000960)1.87951195
78Hypoplasia of the maxilla (HP:0000327)1.86975179
79Inappropriate behavior (HP:0000719)1.86888233
80Hypoplastic labia majora (HP:0000059)1.85774722
81Cutaneous finger syndactyly (HP:0010554)1.85757890
82Bifid tongue (HP:0010297)1.85500178
83Tubular atrophy (HP:0000092)1.85343199
84Abnormality of the pubic bones (HP:0003172)1.84039799
85Astrocytoma (HP:0009592)1.83920080
86Abnormality of the astrocytes (HP:0100707)1.83920080
87Subacute progressive viral hepatitis (HP:0006572)1.83790721
88Neoplasm of the oral cavity (HP:0100649)1.83784128
89Glioma (HP:0009733)1.83433875
90Atonic seizures (HP:0010819)1.82587309
91Highly arched eyebrow (HP:0002553)1.82269279
92Overriding aorta (HP:0002623)1.81847785
93Microglossia (HP:0000171)1.81378705
94Tubulointerstitial abnormality (HP:0001969)1.81020300
95Abnormality of the labia minora (HP:0012880)1.80668314
96Attenuation of retinal blood vessels (HP:0007843)1.79955876
97Abnormality of the parietal bone (HP:0002696)1.79952428
98Postaxial foot polydactyly (HP:0001830)1.79640480
99Smooth philtrum (HP:0000319)1.79402114
100Hip dysplasia (HP:0001385)1.79373751
101Increased number of teeth (HP:0011069)1.79235519
102Astigmatism (HP:0000483)1.78110208
103Keratoconus (HP:0000563)1.77569721
104Increased corneal curvature (HP:0100692)1.77569721
105Omphalocele (HP:0001539)1.76228099
106Central scotoma (HP:0000603)1.76135560
107Hypothermia (HP:0002045)1.74184213
108Congenital hepatic fibrosis (HP:0002612)1.74060409
109Cutaneous syndactyly (HP:0012725)1.72843261
110Hypoplasia of the iris (HP:0007676)1.72185737
111Deep philtrum (HP:0002002)1.71773963
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.71670077
113Enlarged penis (HP:0000040)1.70446848
114Fibular hypoplasia (HP:0003038)1.70082298
115Oligodactyly (hands) (HP:0001180)1.70047004
116Flat cornea (HP:0007720)1.69207211
117Long eyelashes (HP:0000527)1.69044538
118Transitional cell carcinoma of the bladder (HP:0006740)1.68995449
119Urinary bladder sphincter dysfunction (HP:0002839)1.68807790
120Cystic hygroma (HP:0000476)1.67638986
121Skull defect (HP:0001362)1.65985881
122Aplasia/Hypoplasia of the tongue (HP:0010295)1.65414932
123Bony spicule pigmentary retinopathy (HP:0007737)1.65209200
124Long clavicles (HP:0000890)1.65145533
125Absence seizures (HP:0002121)1.65035158
126Exotropia (HP:0000577)1.63296541
127Medulloblastoma (HP:0002885)1.62803455
128Broad thumb (HP:0011304)1.62580473
129EEG with generalized epileptiform discharges (HP:0011198)1.62426667
130Abnormality of the labia majora (HP:0012881)1.62098258
131Supernumerary ribs (HP:0005815)1.61817487
132Aplasia/Hypoplasia of the lens (HP:0008063)1.61665503
133Thyroid carcinoma (HP:0002890)1.60979993
134Postaxial hand polydactyly (HP:0001162)1.60046940
135Dysmetric saccades (HP:0000641)1.59657817
136Tapered finger (HP:0001182)1.59057741
137Renal hypoplasia (HP:0000089)1.59029972
138Epileptiform EEG discharges (HP:0011182)1.58999192
139Sandal gap (HP:0001852)1.58612411
140Round face (HP:0000311)1.58186586
141Albinism (HP:0001022)1.57772448
142Preaxial foot polydactyly (HP:0001841)1.57654844
143Amyotrophic lateral sclerosis (HP:0007354)1.57554407
144Chronic hepatic failure (HP:0100626)1.57469315
145Bowel diverticulosis (HP:0005222)1.55416395
146Abnormality of macular pigmentation (HP:0008002)1.54779785
147Leiomyosarcoma (HP:0100243)1.54324782
148Uterine leiomyosarcoma (HP:0002891)1.54324782
149Cortical dysplasia (HP:0002539)1.53082619
150Dental malocclusion (HP:0000689)1.52761572
151Insidious onset (HP:0003587)1.52043051
152Termporal pattern (HP:0011008)1.52043051
153Oligodactyly (HP:0012165)1.51496515
154Widely spaced teeth (HP:0000687)1.51205388
155Labial hypoplasia (HP:0000066)1.51017551
156Gait imbalance (HP:0002141)1.49854385
157Vesicoureteral reflux (HP:0000076)1.49548361
158Absent speech (HP:0001344)1.49245959
159Anophthalmia (HP:0000528)1.49212812
160Epileptic encephalopathy (HP:0200134)1.49031009
161Abnormality of chromosome segregation (HP:0002916)1.48473776
162Anal stenosis (HP:0002025)1.48219243
163Bladder neoplasm (HP:0009725)1.48108513
164Bladder carcinoma (HP:0002862)1.48108513
165Vitreoretinal degeneration (HP:0000655)1.46988941
166Scotoma (HP:0000575)1.46819594
167Intellectual disability, moderate (HP:0002342)1.46761087
168Broad finger (HP:0001500)1.46412496
169Exostoses (HP:0100777)1.46220308
170Severe visual impairment (HP:0001141)1.45769044
171Truncal ataxia (HP:0002078)1.45119665
172Agitation (HP:0000713)1.44303352
173Broad phalanges of the hand (HP:0009768)1.44089063
174Impaired smooth pursuit (HP:0007772)1.43385699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.46263174
2LATS12.96382175
3CDK122.86630110
4BMPR1B2.45380085
5ACVR1B2.30062651
6FGFR22.28633975
7BRD42.25175608
8ERBB32.22533762
9CAMK1G2.20465700
10RIPK12.05245996
11NTRK21.96994108
12NTRK31.92081867
13MAP3K41.86016692
14CAMK1D1.82963588
15MAPK131.66795283
16PDGFRA1.66409142
17KSR11.65687246
18STK38L1.59037410
19FRK1.55478871
20NLK1.46924394
21CDC71.39616930
22PNCK1.32687923
23PRKD31.31218678
24MUSK1.30691568
25SIK21.30289680
26STK391.29135370
27PHKG21.28894982
28PHKG11.28894982
29GRK11.19856240
30WNK31.19609515
31CSNK1A1L1.15879738
32SRPK11.13804283
33MINK11.11274112
34TNIK1.10574953
35DYRK1A1.10468134
36FGFR11.10424780
37CASK1.09574815
38DMPK1.08486413
39INSRR1.08485156
40FGFR31.07599838
41TAOK31.07570619
42NUAK11.07180659
43MAP4K21.06650060
44CSNK1G21.06564906
45PAK61.06501517
46MTOR1.05301724
47TYRO31.04304651
48SGK21.03599473
49SIK11.03562597
50EPHA31.00760546
51PDGFRB0.99953203
52CDC42BPA0.98656439
53DDR20.98559676
54TRPM70.98352034
55MARK20.98346467
56AKT30.98173398
57MKNK20.97845811
58DYRK20.95526937
59SCYL20.94285874
60PINK10.91698922
61ADRBK20.91253791
62OBSCN0.89611706
63SGK30.86175356
64PRKCE0.84142882
65ICK0.83747211
66CDK30.83382341
67CDK90.80987023
68BCR0.80966716
69MAP2K70.80211051
70STK380.78975438
71RET0.77738779
72MYLK0.77029612
73CSNK1D0.76570307
74ATM0.75860380
75MAP3K100.75303534
76ERBB20.75137071
77PRKAA10.74161227
78PRKCH0.73536547
79LATS20.73457035
80PLK20.72630162
81PAK30.71638696
82CDK60.70833172
83MAP3K70.70425809
84PIK3CG0.70307074
85OXSR10.70192685
86MAP3K60.69665189
87CAMKK20.69630581
88ADRBK10.68647749
89BRSK20.68534203
90ATR0.68532489
91SGK10.68317959
92NEK90.67894969
93WNK10.66336636
94CHEK10.65161891
95EIF2AK30.65108909
96PTK60.64691853
97PLK30.63882278
98MAPK100.63861710
99CDK10.63573040
100CAMK40.63533005
101PKN10.62995104
102GSK3B0.62306348
103RPS6KB10.62204002
104PRKDC0.61219277
105PRKAA20.60974004
106CSNK1G10.59061076
107PTK2B0.58980343
108DYRK1B0.58698608
109TGFBR10.58380014
110MAPK80.57804174
111SGK4940.57543499
112SGK2230.57543499
113MELK0.56931391
114MAP2K40.56325307
115MAPK140.55811999
116PRKCZ0.54870722
117STK30.54839226
118EPHB20.54529187
119CDK20.53791686
120JAK10.53675421
121WNK40.53067922
122UHMK10.53057878
123NEK20.52625378
124MKNK10.51164910
125MAPK90.51068722
126ERBB40.51035185
127CSNK1G30.50977227
128CDK50.50355398
129FER0.50080890
130PIK3CA0.49740488
131MAP3K90.49721721
132EPHA40.49265443
133PRKCG0.47614446
134CAMK2A0.47069956
135WEE10.46092698
136CAMK10.45789179
137PRKG10.41127512
138STK110.40854767
139ROCK10.38325412
140PRKACB0.35988915
141MAPKAPK50.34994137
142RPS6KA30.33793849
143NEK60.32151547

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.10839920
2ABC transporters_Homo sapiens_hsa020101.91299953
3Phototransduction_Homo sapiens_hsa047441.76046210
4Basal cell carcinoma_Homo sapiens_hsa052171.68985833
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.68149965
6Circadian entrainment_Homo sapiens_hsa047131.66991473
7GABAergic synapse_Homo sapiens_hsa047271.62625505
8Endometrial cancer_Homo sapiens_hsa052131.60702835
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57852546
10Axon guidance_Homo sapiens_hsa043601.56683998
11Butanoate metabolism_Homo sapiens_hsa006501.55818807
12Insulin secretion_Homo sapiens_hsa049111.55097766
13Lysine degradation_Homo sapiens_hsa003101.54132507
14Thyroid hormone signaling pathway_Homo sapiens_hsa049191.54000373
15Type II diabetes mellitus_Homo sapiens_hsa049301.51037840
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49098783
17Hedgehog signaling pathway_Homo sapiens_hsa043401.47802159
18Colorectal cancer_Homo sapiens_hsa052101.46617238
19Glutamatergic synapse_Homo sapiens_hsa047241.46514038
20Morphine addiction_Homo sapiens_hsa050321.45175900
21mTOR signaling pathway_Homo sapiens_hsa041501.43843623
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43026731
23Dopaminergic synapse_Homo sapiens_hsa047281.40728490
24Glioma_Homo sapiens_hsa052141.40230065
25Long-term potentiation_Homo sapiens_hsa047201.38692439
26Wnt signaling pathway_Homo sapiens_hsa043101.36363184
27Adherens junction_Homo sapiens_hsa045201.31685739
28MicroRNAs in cancer_Homo sapiens_hsa052061.29842764
29Cholinergic synapse_Homo sapiens_hsa047251.29145926
30Circadian rhythm_Homo sapiens_hsa047101.28946853
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28670488
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28082152
33ErbB signaling pathway_Homo sapiens_hsa040121.27155038
34Renin secretion_Homo sapiens_hsa049241.25127683
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.23396765
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22771330
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22179086
38Hippo signaling pathway_Homo sapiens_hsa043901.21435425
39Fatty acid biosynthesis_Homo sapiens_hsa000611.20088627
40Amphetamine addiction_Homo sapiens_hsa050311.16847164
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16244953
42Dorso-ventral axis formation_Homo sapiens_hsa043201.15867826
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15847047
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.15786302
45Estrogen signaling pathway_Homo sapiens_hsa049151.15771393
46Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15147161
47mRNA surveillance pathway_Homo sapiens_hsa030151.14504417
48Propanoate metabolism_Homo sapiens_hsa006401.14253694
49Olfactory transduction_Homo sapiens_hsa047401.12554875
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.12423850
51Oocyte meiosis_Homo sapiens_hsa041141.09522949
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09266987
53* Fanconi anemia pathway_Homo sapiens_hsa034601.08976757
54Non-homologous end-joining_Homo sapiens_hsa034501.08267924
55Chronic myeloid leukemia_Homo sapiens_hsa052201.08204314
56Tryptophan metabolism_Homo sapiens_hsa003801.08107551
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.06883276
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06355216
59Gap junction_Homo sapiens_hsa045401.05999070
60Prostate cancer_Homo sapiens_hsa052151.05617131
61Alcoholism_Homo sapiens_hsa050341.05219146
62Nitrogen metabolism_Homo sapiens_hsa009101.04855926
63Oxytocin signaling pathway_Homo sapiens_hsa049211.04726493
64Cocaine addiction_Homo sapiens_hsa050301.04355877
65Long-term depression_Homo sapiens_hsa047301.04260187
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03592336
67Melanogenesis_Homo sapiens_hsa049161.03538214
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03415561
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02654997
70GnRH signaling pathway_Homo sapiens_hsa049121.00700022
71cAMP signaling pathway_Homo sapiens_hsa040240.99297823
72Synaptic vesicle cycle_Homo sapiens_hsa047210.97098414
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96079596
74Notch signaling pathway_Homo sapiens_hsa043300.95940505
75Salivary secretion_Homo sapiens_hsa049700.95336292
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95073427
77Taste transduction_Homo sapiens_hsa047420.94793391
78Dilated cardiomyopathy_Homo sapiens_hsa054140.94460227
79Renal cell carcinoma_Homo sapiens_hsa052110.93731310
80Choline metabolism in cancer_Homo sapiens_hsa052310.91805097
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91423555
82TGF-beta signaling pathway_Homo sapiens_hsa043500.91283235
83Serotonergic synapse_Homo sapiens_hsa047260.91247337
84Non-small cell lung cancer_Homo sapiens_hsa052230.90889479
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.89429754
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88747643
87Pancreatic cancer_Homo sapiens_hsa052120.88225135
88Focal adhesion_Homo sapiens_hsa045100.87960437
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87391940
90Selenocompound metabolism_Homo sapiens_hsa004500.86548031
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.85801558
92Melanoma_Homo sapiens_hsa052180.84778533
93Gastric acid secretion_Homo sapiens_hsa049710.84493263
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83338544
95MAPK signaling pathway_Homo sapiens_hsa040100.83195647
96Glucagon signaling pathway_Homo sapiens_hsa049220.82241087
97Proteoglycans in cancer_Homo sapiens_hsa052050.82129023
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80000047
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.78958337
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78714110
101Cell cycle_Homo sapiens_hsa041100.78690258
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78611424
103FoxO signaling pathway_Homo sapiens_hsa040680.77620460
104Viral myocarditis_Homo sapiens_hsa054160.77497436
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.76739351
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76227473
107Glycerolipid metabolism_Homo sapiens_hsa005610.75865180
108AMPK signaling pathway_Homo sapiens_hsa041520.75708890
109Insulin signaling pathway_Homo sapiens_hsa049100.75636865
110Pathways in cancer_Homo sapiens_hsa052000.74212607
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71787573
112Calcium signaling pathway_Homo sapiens_hsa040200.71784273
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.71324486
114Protein digestion and absorption_Homo sapiens_hsa049740.71225068
115Histidine metabolism_Homo sapiens_hsa003400.69893247
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69555220
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69215030
118Ether lipid metabolism_Homo sapiens_hsa005650.69193426
119Thyroid hormone synthesis_Homo sapiens_hsa049180.68040175
120ECM-receptor interaction_Homo sapiens_hsa045120.67843233
121Prolactin signaling pathway_Homo sapiens_hsa049170.67069300
122Linoleic acid metabolism_Homo sapiens_hsa005910.66695087
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.65849577
124Small cell lung cancer_Homo sapiens_hsa052220.65375646
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65216289
126Rap1 signaling pathway_Homo sapiens_hsa040150.65069544
127Insulin resistance_Homo sapiens_hsa049310.65019557
128Ovarian steroidogenesis_Homo sapiens_hsa049130.63938959
129Inositol phosphate metabolism_Homo sapiens_hsa005620.63838470
130Basal transcription factors_Homo sapiens_hsa030220.61783415
131Ras signaling pathway_Homo sapiens_hsa040140.61679810
132Pancreatic secretion_Homo sapiens_hsa049720.60685651
133Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59217600
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58902401
135Sphingolipid metabolism_Homo sapiens_hsa006000.58190127
136Platelet activation_Homo sapiens_hsa046110.53663047
137PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52756576

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