REXO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)4.85450706
2negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.42065373
3pre-miRNA processing (GO:0031054)4.39371821
4regulation of gamma-delta T cell differentiation (GO:0045586)4.01253377
5negative regulation of RNA splicing (GO:0033119)3.99656874
6positive regulation of histone deacetylation (GO:0031065)3.91028011
7heterochromatin organization (GO:0070828)3.80305697
8DNA unwinding involved in DNA replication (GO:0006268)3.79882725
9negative regulation of mRNA processing (GO:0050686)3.78367601
10negative regulation of histone methylation (GO:0031061)3.77994594
11mannose metabolic process (GO:0006013)3.75303529
12intracellular estrogen receptor signaling pathway (GO:0030520)3.67176894
13positive T cell selection (GO:0043368)3.66682060
14response to muramyl dipeptide (GO:0032495)3.66525407
15negative regulation of mRNA metabolic process (GO:1903312)3.62797314
16regulation of histone H3-K9 methylation (GO:0051570)3.54354755
17regulation of RNA export from nucleus (GO:0046831)3.53484294
18thymic T cell selection (GO:0045061)3.52265506
19regulation of gamma-delta T cell activation (GO:0046643)3.47563117
20protein localization to kinetochore (GO:0034501)3.47495373
21protein-DNA complex disassembly (GO:0032986)3.42835132
22nucleosome disassembly (GO:0006337)3.42835132
23RNA stabilization (GO:0043489)3.42003964
24mRNA stabilization (GO:0048255)3.42003964
25chromatin silencing (GO:0006342)3.41959536
26positive regulation of gamma-delta T cell activation (GO:0046645)3.41795115
27protein localization to chromosome, centromeric region (GO:0071459)3.37537722
28NIK/NF-kappaB signaling (GO:0038061)3.35200906
29regulation of translational fidelity (GO:0006450)3.31470701
30regulation of NFAT protein import into nucleus (GO:0051532)3.31086421
31negative regulation of gene expression, epigenetic (GO:0045814)3.30638116
32negative regulation of cell killing (GO:0031342)3.29704443
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.29704443
34protein localization to endosome (GO:0036010)3.27662744
35positive regulation of gene expression, epigenetic (GO:0045815)3.25875460
363-UTR-mediated mRNA stabilization (GO:0070935)3.25659530
37mitotic nuclear envelope disassembly (GO:0007077)3.24874527
38chromatin assembly (GO:0031497)3.20927449
39modulation by symbiont of host cellular process (GO:0044068)3.18586107
40response to laminar fluid shear stress (GO:0034616)3.17970612
41regulation of T-helper 2 cell differentiation (GO:0045628)3.16429095
42positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15942213
43modulation by virus of host process (GO:0019054)3.14037527
44mitotic sister chromatid cohesion (GO:0007064)3.10571146
45positive regulation of RNA splicing (GO:0033120)3.09321641
46response to peptidoglycan (GO:0032494)3.09046812
47negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.08993063
48peptidyl-lysine dimethylation (GO:0018027)3.08424976
49positive regulation by symbiont of host defense response (GO:0052509)3.05763301
50modulation by symbiont of host defense response (GO:0052031)3.05763301
51modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.05763301
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.05763301
53positive regulation by organism of defense response of other organism involved in symbiotic interact3.05763301
54modulation by symbiont of host immune response (GO:0052553)3.05763301
55nuclear pore complex assembly (GO:0051292)3.05079694
56regulation of ARF GTPase activity (GO:0032312)3.04826412
57nuclear envelope disassembly (GO:0051081)3.03320633
58membrane disassembly (GO:0030397)3.03320633
59regulation of nucleobase-containing compound transport (GO:0032239)3.01220116
60maternal placenta development (GO:0001893)3.00890826
61T cell selection (GO:0045058)3.00811849
62embryonic process involved in female pregnancy (GO:0060136)3.00755215
63mitotic G1 DNA damage checkpoint (GO:0031571)3.00582171
64spliceosomal tri-snRNP complex assembly (GO:0000244)3.00297179
65regulation of early endosome to late endosome transport (GO:2000641)2.99507675
66DNA duplex unwinding (GO:0032508)2.97006048
67regulation of chromatin binding (GO:0035561)2.96739200
68negative regulation of erythrocyte differentiation (GO:0045647)2.96684473
69antigen processing and presentation of endogenous antigen (GO:0019883)2.96250904
70dosage compensation (GO:0007549)2.95207628
71adherens junction assembly (GO:0034333)2.93386993
72DNA geometric change (GO:0032392)2.93036265
73activation of MAPKKK activity (GO:0000185)2.90902436
74nuclear pore organization (GO:0006999)2.90701821
75germinal center formation (GO:0002467)2.90214187
76regulation of histone H3-K27 methylation (GO:0061085)2.88609018
77viral transcription (GO:0019083)2.87306404
78activation of Rac GTPase activity (GO:0032863)2.87249840
79positive regulation of protein deacetylation (GO:0090312)2.87059390
80apoptotic process involved in morphogenesis (GO:0060561)2.86620695
81regulation of ARF protein signal transduction (GO:0032012)2.86057736
82positive regulation by host of viral transcription (GO:0043923)2.85653868
83gene silencing (GO:0016458)2.85040612
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.83010755
85mitotic G1/S transition checkpoint (GO:0044819)2.79875455
86cell-substrate adherens junction assembly (GO:0007045)2.79749661
87focal adhesion assembly (GO:0048041)2.79749661
88histone H3-K36 demethylation (GO:0070544)2.78333839
89signal complex assembly (GO:0007172)2.78197515
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76394427
91histone H2A monoubiquitination (GO:0035518)2.76263517
92negative regulation of cell size (GO:0045792)2.75225076
93mitotic chromosome condensation (GO:0007076)2.74712066
94negative regulation of glial cell proliferation (GO:0060253)2.72672667
95mitotic sister chromatid segregation (GO:0000070)2.72530679
96regulation of mRNA stability (GO:0043488)2.71680309
97natural killer cell differentiation (GO:0001779)2.71332690
98leukocyte aggregation (GO:0070486)2.71047645
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.70160560
100stress fiber assembly (GO:0043149)2.69839122
101translational termination (GO:0006415)2.69036598
102activation of JUN kinase activity (GO:0007257)2.68463995
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.68243287
104tolerance induction (GO:0002507)2.67803024
105histone H4-K12 acetylation (GO:0043983)2.67679185
106negative thymic T cell selection (GO:0045060)2.67554436
107regulation of leukocyte degranulation (GO:0043300)2.66297045
108sister chromatid segregation (GO:0000819)2.65886103
109trophectodermal cell differentiation (GO:0001829)2.65863225
110folic acid-containing compound biosynthetic process (GO:0009396)2.65503532
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.65135826
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65135826
113macrophage activation involved in immune response (GO:0002281)2.64845081
114DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.64268928
115regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62907559
116DNA conformation change (GO:0071103)2.62647343
117regulation of sister chromatid cohesion (GO:0007063)2.62275044
118histone H3-K4 methylation (GO:0051568)2.61993939
119regulation of RNA stability (GO:0043487)2.61476867
120regulation of histone methylation (GO:0031060)2.61022567
121chromosome condensation (GO:0030261)2.60853222
122regulation of histone H3-K4 methylation (GO:0051569)2.60384040
123nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.60046902
124alternative mRNA splicing, via spliceosome (GO:0000380)2.59314395
125lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58426752
126histone H3-K9 methylation (GO:0051567)2.57851338
127establishment of apical/basal cell polarity (GO:0035089)2.57640479
128nodal signaling pathway (GO:0038092)2.57165675
129detection of bacterium (GO:0016045)2.56974270
130negative regulation of toll-like receptor signaling pathway (GO:0034122)2.56626272
131cellular response to virus (GO:0098586)2.56027193
132DNA strand elongation involved in DNA replication (GO:0006271)2.55539067
133positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.55420044
134gastrulation with mouth forming second (GO:0001702)2.55101498
135translesion synthesis (GO:0019985)2.54851967
136positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.54628755
137nuclear envelope organization (GO:0006998)2.54474015
138chromatin assembly or disassembly (GO:0006333)2.53439518
139V(D)J recombination (GO:0033151)2.53062752
140histone H4-K16 acetylation (GO:0043984)2.52843382
141histone H4 deacetylation (GO:0070933)2.52021163
142maturation of SSU-rRNA (GO:0030490)2.51886316
143detection of other organism (GO:0098543)2.50315132
144translational elongation (GO:0006414)2.50281512
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.49972114
146formation of translation preinitiation complex (GO:0001731)2.49862609
147DNA replication-dependent nucleosome organization (GO:0034723)2.48808021
148DNA replication-dependent nucleosome assembly (GO:0006335)2.48808021
149histone H3 acetylation (GO:0043966)2.48795058
150negative regulation of histone modification (GO:0031057)2.47668112
151positive regulation of Rap GTPase activity (GO:0032854)2.47272498
152DNA topological change (GO:0006265)2.46363399
153cellular hyperosmotic response (GO:0071474)2.45615645
154histone H4 acetylation (GO:0043967)2.45488751
155G1 DNA damage checkpoint (GO:0044783)2.45229190
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.44209502
157negative regulation of viral release from host cell (GO:1902187)2.44038111
158negative regulation of myotube differentiation (GO:0010832)2.43529551
159positive regulation of protein dephosphorylation (GO:0035307)2.42632889
160negative T cell selection (GO:0043383)2.42404057
161regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41903882
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.39723881
163regulation of extracellular matrix disassembly (GO:0010715)2.37973482
164positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.36496621
165regulation of defense response to virus by virus (GO:0050690)2.35361597
166cell-cell junction maintenance (GO:0045217)2.33843028
167cell-substrate junction assembly (GO:0007044)2.31265740
168histone lysine demethylation (GO:0070076)2.30858896
169negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.30277013
170regulation of mast cell degranulation (GO:0043304)2.29641639
171positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.29029119
172positive regulation of blood vessel endothelial cell migration (GO:0043536)2.28838136
173pinocytosis (GO:0006907)2.28681813
174barbed-end actin filament capping (GO:0051016)2.28037420
175positive regulation of myotube differentiation (GO:0010831)2.25882932
176histone H3 deacetylation (GO:0070932)2.25788151
177histone demethylation (GO:0016577)2.21159635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.11450550
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32597383
3MYC_22102868_ChIP-Seq_BL_Human4.25719699
4* VDR_21846776_ChIP-Seq_THP-1_Human3.14416491
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.94064638
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.92173155
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.71145518
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55726170
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.49705457
10KDM2B_26808549_Chip-Seq_DND41_Human2.49426220
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44810904
12KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.29254425
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27452368
14KDM2B_26808549_Chip-Seq_SUP-B15_Human2.22834035
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18542635
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14264528
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.12338969
18* ELK3_25401928_ChIP-Seq_HUVEC_Human2.00927777
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99110958
20* UTX_26944678_Chip-Seq_JUKART_Human1.98357615
21E2F4_17652178_ChIP-ChIP_JURKAT_Human1.94461985
22MAF_26560356_Chip-Seq_TH1_Human1.94010324
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.93836854
24* CIITA_25753668_ChIP-Seq_RAJI_Human1.89304076
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87999715
26LXR_22292898_ChIP-Seq_THP-1_Human1.81932147
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81601853
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69058104
29* VDR_24763502_ChIP-Seq_THP-1_Human1.68907483
30MAF_26560356_Chip-Seq_TH2_Human1.66324551
31SCL_19346495_ChIP-Seq_HPC-7_Human1.64325864
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59461217
33ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57423883
34KDM2B_26808549_Chip-Seq_JURKAT_Human1.55517468
35* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53678230
36ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53045749
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49575237
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46357679
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45677911
40SMC4_20622854_ChIP-Seq_HELA_Human1.42012524
41XRN2_22483619_ChIP-Seq_HELA_Human1.38629032
42ZNF263_19887448_ChIP-Seq_K562_Human1.37526790
43* NCOR1_26117541_ChIP-Seq_K562_Human1.36727132
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.36256334
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35831943
46MYB_26560356_Chip-Seq_TH1_Human1.33318246
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32338604
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32153349
49RACK7_27058665_Chip-Seq_MCF-7_Human1.31927993
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.31606625
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30676209
52P68_20966046_ChIP-Seq_HELA_Human1.29767339
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.29628581
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29563319
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29016397
56* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29001983
57KDM5A_27292631_Chip-Seq_BREAST_Human1.27632505
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27531646
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.27377778
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.26499958
61* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25348952
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24974301
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.24158588
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23948039
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.23335162
66KDM2B_26808549_Chip-Seq_K562_Human1.23082936
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23007694
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22846016
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22103118
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.21734610
71DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21697194
72FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21085720
73* MYB_26560356_Chip-Seq_TH2_Human1.20695998
74* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19113732
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18927051
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17102191
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17045017
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.16699597
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16653785
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15389643
81* GATA1_19941826_ChIP-Seq_K562_Human1.14021711
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.13556731
83* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13330889
84* BCL6_27268052_Chip-Seq_Bcells_Human1.11934095
85KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11853752
86* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11003702
87* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10913664
88MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10873658
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10670705
90STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10475599
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10182819
92SPI1_23127762_ChIP-Seq_K562_Human1.09955324
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.09753363
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08223033
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07853746
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07806849
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.06846097
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.06289281
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.06069998
100KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05594906
101KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05594906
102KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05594906
103* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05328548
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04391030
105* CREB1_26743006_Chip-Seq_LNCaP_Human1.04233666
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04096535
107ATF3_27146783_Chip-Seq_COLON_Human1.03521740
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03128076
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02599357
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02120375
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.01002008
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00646649
113CTCF_27219007_Chip-Seq_Bcells_Human1.00645190
114PHF8_20622854_ChIP-Seq_HELA_Human1.00165602
115NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99126126
116* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98783405
117* CTCF_21964334_Chip-Seq_Bcells_Human0.98672806
118MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98642426
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98541626
120CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98056516
121KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97674173
122SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97267966
123* BCOR_27268052_Chip-Seq_Bcells_Human0.97109117
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96339852
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96141473
126TP53_22127205_ChIP-Seq_IMR90_Human0.95177526
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94884198
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.94672050
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94449038
130DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94282546
131TET1_21451524_ChIP-Seq_MESCs_Mouse0.92829619
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91458964
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90381413
134MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88901117
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.86547522

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow3.80373666
2MP0003303_peritoneal_inflammation3.71074270
3MP0003111_abnormal_nucleus_morphology3.19617127
4MP0005076_abnormal_cell_differentiation3.12166384
5MP0005451_abnormal_body_composition3.11454960
6MP0010094_abnormal_chromosome_stability2.55723663
7MP0003077_abnormal_cell_cycle2.52683943
8MP0008057_abnormal_DNA_replication2.49969306
9MP0005058_abnormal_lysosome_morphology2.48087246
10MP0003172_abnormal_lysosome_physiology2.45641993
11MP0008260_abnormal_autophagy2.44928088
12MP0010352_gastrointestinal_tract_polyps2.38506702
13MP0001545_abnormal_hematopoietic_system2.26014012
14MP0005397_hematopoietic_system_phenotyp2.26014012
15MP0003705_abnormal_hypodermis_morpholog2.24645646
16MP0003693_abnormal_embryo_hatching2.23080567
17MP0002396_abnormal_hematopoietic_system2.22228853
18MP0002653_abnormal_ependyma_morphology2.21941525
19MP0004957_abnormal_blastocyst_morpholog2.17281511
20MP0003763_abnormal_thymus_physiology2.15701669
21MP0004808_abnormal_hematopoietic_stem2.15565079
22MP0000685_abnormal_immune_system2.05599479
23MP0009840_abnormal_foam_cell2.03421550
24MP0000703_abnormal_thymus_morphology1.93675864
25MP0001730_embryonic_growth_arrest1.81266863
26MP0003300_gastrointestinal_ulcer1.80491804
27MP0000678_abnormal_parathyroid_gland1.80465852
28MP0008961_abnormal_basal_metabolism1.78657368
29MP0002398_abnormal_bone_marrow1.73772793
30MP0001348_abnormal_lacrimal_gland1.73207361
31MP0008995_early_reproductive_senescence1.72153509
32MP0000350_abnormal_cell_proliferation1.72009296
33MP0003191_abnormal_cellular_cholesterol1.68315652
34MP0005025_abnormal_response_to1.64416855
35MP0004858_abnormal_nervous_system1.63641694
36MP0002084_abnormal_developmental_patter1.63565028
37MP0004197_abnormal_fetal_growth/weight/1.63182594
38MP0002419_abnormal_innate_immunity1.63037329
39MP0002877_abnormal_melanocyte_morpholog1.57406269
40MP0005409_darkened_coat_color1.55359615
41MP0008877_abnormal_DNA_methylation1.50905043
42MP0001672_abnormal_embryogenesis/_devel1.49786379
43MP0005380_embryogenesis_phenotype1.49786379
44MP0001835_abnormal_antigen_presentation1.49658755
45MP0002722_abnormal_immune_system1.48853772
46MP0005666_abnormal_adipose_tissue1.48828303
47MP0001800_abnormal_humoral_immune1.48485166
48MP0003283_abnormal_digestive_organ1.45895446
49MP0008007_abnormal_cellular_replicative1.45854851
50MP0000689_abnormal_spleen_morphology1.45833428
51MP0002085_abnormal_embryonic_tissue1.45049440
52MP0002086_abnormal_extraembryonic_tissu1.43799907
53MP0001697_abnormal_embryo_size1.42621205
54MP0003984_embryonic_growth_retardation1.42371693
55MP0002088_abnormal_embryonic_growth/wei1.41703708
56MP0001533_abnormal_skeleton_physiology1.39160034
57MP0000490_abnormal_crypts_of1.34493751
58MP0002080_prenatal_lethality1.34451478
59MP0002019_abnormal_tumor_incidence1.34054215
60MP0002998_abnormal_bone_remodeling1.30839940
61MP0005375_adipose_tissue_phenotype1.29341166
62MP0010307_abnormal_tumor_latency1.27432314
63MP0005464_abnormal_platelet_physiology1.24637767
64MP0000716_abnormal_immune_system1.23993542
65MP0002405_respiratory_system_inflammati1.21914973
66MP0000313_abnormal_cell_death1.21822519
67MP0002249_abnormal_larynx_morphology1.19541048
68MP0003279_aneurysm1.18411519
69MP0002429_abnormal_blood_cell1.17987763
70MP0009333_abnormal_splenocyte_physiolog1.15325773
71MP0001873_stomach_inflammation1.14748748
72MP0008058_abnormal_DNA_repair1.12205574
73MP0002089_abnormal_postnatal_growth/wei1.10916992
74MP0009672_abnormal_birth_weight1.10675402
75MP0002796_impaired_skin_barrier1.10518292
76MP0003329_amyloid_beta_deposits1.10203093
77MP0001849_ear_inflammation1.09359910
78MP0002452_abnormal_antigen_presenting1.07928146
79MP0000858_altered_metastatic_potential1.07850275
80MP0005310_abnormal_salivary_gland1.07777277
81MP0003866_abnormal_defecation1.06841714
82MP0003436_decreased_susceptibility_to1.06656598
83MP0003566_abnormal_cell_adhesion1.06551962
84MP0003119_abnormal_digestive_system1.06364948
85MP0003786_premature_aging1.06350016
86MP0002420_abnormal_adaptive_immunity1.06256714
87MP0003115_abnormal_respiratory_system1.06040882
88MP0003724_increased_susceptibility_to1.05072068
89MP0003890_abnormal_embryonic-extraembry1.04851046
90MP0001819_abnormal_immune_cell1.04815449
91MP0005387_immune_system_phenotype1.02626203
92MP0001790_abnormal_immune_system1.02626203
93MP0002254_reproductive_system_inflammat1.02511014
94MP0000003_abnormal_adipose_tissue1.01139926
95MP0005410_abnormal_fertilization1.01010318
96MP0000733_abnormal_muscle_development1.00649300
97MP0005621_abnormal_cell_physiology1.00378600
98MP0001851_eye_inflammation1.00372545
99MP0003075_altered_response_to1.00215403
100MP0010030_abnormal_orbit_morphology0.99448906
101MP0004185_abnormal_adipocyte_glucose0.99339745
102MP0003828_pulmonary_edema0.98722244
103MP0001929_abnormal_gametogenesis0.97865864
104MP0002723_abnormal_immune_serum0.97759241
105MP0002697_abnormal_eye_size0.97593878
106MP0002148_abnormal_hypersensitivity_rea0.96580405
107MP0004381_abnormal_hair_follicle0.96062555
108MP0002210_abnormal_sex_determination0.94998126
109MP0002933_joint_inflammation0.94033242
110MP0009785_altered_susceptibility_to0.93931626
111MP0008770_decreased_survivor_rate0.92572712
112MP0001853_heart_inflammation0.90877100
113MP0002925_abnormal_cardiovascular_devel0.90803870
114MP0008932_abnormal_embryonic_tissue0.88425065
115MP0001145_abnormal_male_reproductive0.88419233
116MP0004859_abnormal_synaptic_plasticity0.87856679
117MP0009703_decreased_birth_body0.86600573
118MP0003123_paternal_imprinting0.85692764
119MP0010234_abnormal_vibrissa_follicle0.85179824
120MP0005671_abnormal_response_to0.84656466
121MP0003787_abnormal_imprinting0.84237340
122MP0002092_abnormal_eye_morphology0.83896870
123MP0004233_abnormal_muscle_weight0.83071390
124MP0005501_abnormal_skin_physiology0.82397313
125MP0006082_CNS_inflammation0.82389359
126MP0001845_abnormal_inflammatory_respons0.82297024
127MP0004510_myositis0.81928586
128MP0004947_skin_inflammation0.80722810
129MP0008874_decreased_physiological_sensi0.80232011
130MP0005390_skeleton_phenotype0.80173563
131MP0000767_abnormal_smooth_muscle0.79832009
132MP0003448_altered_tumor_morphology0.79722101
133MP0000604_amyloidosis0.79273829
134MP0010155_abnormal_intestine_physiology0.77414143
135MP0004133_heterotaxia0.77190415
136MP0005670_abnormal_white_adipose0.76829052
137MP0005166_decreased_susceptibility_to0.76747283
138MP0005174_abnormal_tail_pigmentation0.76681846
139MP0005023_abnormal_wound_healing0.76514452
140MP0003121_genomic_imprinting0.76167881
141MP0009931_abnormal_skin_appearance0.75797318
142MP0003091_abnormal_cell_migration0.75618597
143MP0005000_abnormal_immune_tolerance0.75139476
144MP0002132_abnormal_respiratory_system0.73706247
145MP0003656_abnormal_erythrocyte_physiolo0.73542232
146MP0003453_abnormal_keratinocyte_physiol0.73045654
147MP0003861_abnormal_nervous_system0.71840110
148MP0001293_anophthalmia0.71619399
149MP0003690_abnormal_glial_cell0.71328477
150MP0010630_abnormal_cardiac_muscle0.69930224
151MP0005623_abnormal_meninges_morphology0.69745954
152MP0000759_abnormal_skeletal_muscle0.69693620
153MP0000681_abnormal_thyroid_gland0.69439465

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.45878593
2Hyperacusis (HP:0010780)4.45580219
3Nasal polyposis (HP:0100582)3.87280323
4Obstructive sleep apnea (HP:0002870)3.83412463
5Eczematoid dermatitis (HP:0000976)3.32340311
6Abnormality of the nasal mucosa (HP:0000433)3.29835861
7Rectal prolapse (HP:0002035)3.21260865
8Broad face (HP:0000283)3.02970745
9Basal cell carcinoma (HP:0002671)2.98111484
10Renovascular hypertension (HP:0100817)2.84772929
11Short 4th metacarpal (HP:0010044)2.81960186
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.81960186
13Cerebral aneurysm (HP:0004944)2.80012509
14Distal lower limb amyotrophy (HP:0008944)2.74940461
15Hypochromic anemia (HP:0001931)2.74456951
16Insomnia (HP:0100785)2.66725405
17Renal duplication (HP:0000075)2.59143798
18Increased connective tissue (HP:0009025)2.50613996
19Disproportionate tall stature (HP:0001519)2.46738188
20Supernumerary ribs (HP:0005815)2.45599150
21Selective tooth agenesis (HP:0001592)2.45584627
22Elfin facies (HP:0004428)2.43775986
23Overriding aorta (HP:0002623)2.43178625
24Gastrointestinal infarctions (HP:0005244)2.42522951
25Increased nuchal translucency (HP:0010880)2.40962215
26Heterotopia (HP:0002282)2.40152911
27Upper limb amyotrophy (HP:0009129)2.38027443
28Distal upper limb amyotrophy (HP:0007149)2.38027443
29Abnormality of macrophages (HP:0004311)2.34117562
30Ulnar bowing (HP:0003031)2.33039547
31Panhypogammaglobulinemia (HP:0003139)2.30989334
32Thin bony cortex (HP:0002753)2.28068617
33Rib fusion (HP:0000902)2.27492621
34Long palpebral fissure (HP:0000637)2.24863087
35Centrally nucleated skeletal muscle fibers (HP:0003687)2.24648532
36Cellulitis (HP:0100658)2.24403674
37Long eyelashes (HP:0000527)2.23277753
38Ependymoma (HP:0002888)2.22621638
39Abnormal number of erythroid precursors (HP:0012131)2.21662636
40Achilles tendon contracture (HP:0001771)2.18157809
41Abnormality of cells of the erythroid lineage (HP:0012130)2.17516863
42Stridor (HP:0010307)2.16195385
43Pointed chin (HP:0000307)2.13604428
44Supernumerary bones of the axial skeleton (HP:0009144)2.13031243
45Obstructive lung disease (HP:0006536)2.12750725
46Chronic obstructive pulmonary disease (HP:0006510)2.12750725
47Recurrent bacterial skin infections (HP:0005406)2.10432682
48Recurrent bronchitis (HP:0002837)2.10360827
49Segmental peripheral demyelination/remyelination (HP:0003481)2.09863555
50Slow saccadic eye movements (HP:0000514)2.09529662
51Overlapping toe (HP:0001845)2.09449842
52Polygenic inheritance (HP:0010982)2.08765876
53Recurrent abscess formation (HP:0002722)2.07865080
54Skin tags (HP:0010609)2.06632613
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.06300348
56Supranuclear gaze palsy (HP:0000605)2.05997481
57Broad palm (HP:0001169)2.05945177
58Verrucae (HP:0200043)2.05931542
59Papilloma (HP:0012740)2.05931542
60High pitched voice (HP:0001620)2.04533919
61Hemorrhage of the eye (HP:0011885)2.04514424
62Abnormality of the 4th metacarpal (HP:0010012)2.03252665
63Abnormality of the thoracic spine (HP:0100711)2.02965362
64Recurrent viral infections (HP:0004429)2.02801624
65Medulloblastoma (HP:0002885)2.02634883
66Pseudobulbar signs (HP:0002200)2.01995359
67Acute lymphatic leukemia (HP:0006721)2.01184271
68Lower limb amyotrophy (HP:0007210)2.00701372
69Poikiloderma (HP:0001029)2.00532112
70Protrusio acetabuli (HP:0003179)1.99734019
71Abnormal delayed hypersensitivity skin test (HP:0002963)1.99386675
72Increased density of long bones (HP:0006392)1.99380996
73Prominent nose (HP:0000448)1.99084930
74Abnormal number of incisors (HP:0011064)1.98640695
75Gingivitis (HP:0000230)1.98271818
76Mediastinal lymphadenopathy (HP:0100721)1.97710983
77Squamous cell carcinoma (HP:0002860)1.96906882
78Gastrointestinal inflammation (HP:0004386)1.96785835
79Reticulocytosis (HP:0001923)1.96674725
80Neuronal loss in central nervous system (HP:0002529)1.95585573
81Malignant gastrointestinal tract tumors (HP:0006749)1.94923615
82Gastrointestinal carcinoma (HP:0002672)1.94923615
83Recurrent fungal infections (HP:0002841)1.93922088
84Increased IgE level (HP:0003212)1.93757330
85Distal lower limb muscle weakness (HP:0009053)1.93422885
86Hypertensive crisis (HP:0100735)1.93068534
87Mitral valve prolapse (HP:0001634)1.92474162
88Difficulty climbing stairs (HP:0003551)1.90540102
89Cerebral inclusion bodies (HP:0100314)1.89806944
90Shallow orbits (HP:0000586)1.89387626
91Colitis (HP:0002583)1.89275114
92Increased variability in muscle fiber diameter (HP:0003557)1.88924429
93Abnormality of the Achilles tendon (HP:0005109)1.88878384
94Peripheral hypomyelination (HP:0007182)1.88783746
95Thoracic kyphosis (HP:0002942)1.87938805
96Vertebral arch anomaly (HP:0008438)1.87591280
97Easy fatigability (HP:0003388)1.87387844
98Dysostosis multiplex (HP:0000943)1.86135594
99Bicuspid aortic valve (HP:0001647)1.85453778
100Abnormality of the lower motor neuron (HP:0002366)1.84445974
101Short phalanx of the thumb (HP:0009660)1.84410031
102Abnormality of reticulocytes (HP:0004312)1.84128875
103Gastrointestinal stroma tumor (HP:0100723)1.84112361
104Flat acetabular roof (HP:0003180)1.83944115
105Annular pancreas (HP:0001734)1.83602519
106Flat cornea (HP:0007720)1.83155383
107Bowel incontinence (HP:0002607)1.82712900
108Neoplasm of striated muscle (HP:0009728)1.81874181
109Obsessive-compulsive behavior (HP:0000722)1.81782396
110Myositis (HP:0100614)1.81575772
111Macroorchidism (HP:0000053)1.81232041
112Cholecystitis (HP:0001082)1.80269303
113Abnormal gallbladder physiology (HP:0012438)1.80269303
114Deep palmar crease (HP:0006191)1.80153587
115Meningitis (HP:0001287)1.78120734
116Proximal placement of thumb (HP:0009623)1.77248761
117Mitral regurgitation (HP:0001653)1.77137176
118Neoplasm of the oral cavity (HP:0100649)1.76092108
119Abnormality of the diencephalon (HP:0010662)1.75426924
120Dislocated radial head (HP:0003083)1.75373569
121Bowel diverticulosis (HP:0005222)1.74371993
122Hypertriglyceridemia (HP:0002155)1.73949789
123Inflammation of the large intestine (HP:0002037)1.73708678
124Interstitial pulmonary disease (HP:0006530)1.72909125
125Biliary tract neoplasm (HP:0100574)1.72868951
126Abnormal large intestine physiology (HP:0012700)1.72373613
127Cervical subluxation (HP:0003308)1.72184796
128Polycythemia (HP:0001901)1.72004499
129Abnormality of skeletal muscle fiber size (HP:0012084)1.71989198
130Abnormality of the columella (HP:0009929)1.71362962
131Preauricular skin tag (HP:0000384)1.71043979
132Vertebral fusion (HP:0002948)1.70542155
133Anal stenosis (HP:0002025)1.69615489
134Aneurysm (HP:0002617)1.69012632
135Dysmetric saccades (HP:0000641)1.68726341
136Increased cerebral lipofuscin (HP:0011813)1.68702571
137Deviation of the thumb (HP:0009603)1.68619633
138Loss of speech (HP:0002371)1.67946673
139T lymphocytopenia (HP:0005403)1.67271591
140Syringomyelia (HP:0003396)1.67157337
141Spinal cord lesions (HP:0100561)1.67157337
142Dilatation of the ascending aorta (HP:0005111)1.66571801
143Abnormality of the distal phalanx of the thumb (HP:0009617)1.66445103
144Abnormality of the radial head (HP:0003995)1.66330127
145Vertebral compression fractures (HP:0002953)1.65811095
146Fragile skin (HP:0001030)1.65231010
147Gastrointestinal dysmotility (HP:0002579)1.65116174
148Neurofibrillary tangles (HP:0002185)1.64836596
149Emphysema (HP:0002097)1.64681705
150Hypercortisolism (HP:0001578)1.64592313
151Abdominal situs inversus (HP:0003363)1.64553851
152Abnormality of abdominal situs (HP:0011620)1.64553851
153Genu recurvatum (HP:0002816)1.63646887
154Seborrheic dermatitis (HP:0001051)1.63637823
155Onion bulb formation (HP:0003383)1.63062314
156Myopathic facies (HP:0002058)1.62850878
157Male infertility (HP:0003251)1.62775348
158Reticulocytopenia (HP:0001896)1.61825141
159Megalocornea (HP:0000485)1.61266179
160Urethral obstruction (HP:0000796)1.61263331
161Trigonocephaly (HP:0000243)1.61090216
162Metaphyseal cupping (HP:0003021)1.60859353
163Hand muscle atrophy (HP:0009130)1.60629723
164Pustule (HP:0200039)1.60121357
165Colon cancer (HP:0003003)1.60120651
166Spontaneous hematomas (HP:0007420)1.60078559
167Ankyloglossia (HP:0010296)1.59046392
168Precocious puberty (HP:0000826)1.58986447
169Abnormality of the astrocytes (HP:0100707)1.57867662
170Astrocytoma (HP:0009592)1.57867662
171Hallux valgus (HP:0001822)1.57785951
172Abnormality of the peritoneum (HP:0002585)1.57668414
173Short 5th finger (HP:0009237)1.57548481
174Recurrent otitis media (HP:0000403)1.57093776
175Volvulus (HP:0002580)1.57040149

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.45149232
2PRPF4B4.21917182
3CDK123.78447900
4EEF2K3.57426657
5TRIB33.51145745
6ICK3.06009780
7SMG13.02427575
8MAP4K12.85244666
9PKN22.36282740
10IRAK32.16430698
11RIPK42.06993114
12NEK22.06980791
13CDK191.95658220
14CDC71.86275176
15SIK21.80561031
16TYRO31.79116838
17STK101.75271545
18ERN11.69260303
19MAP3K131.62427251
20CDK41.62242201
21GRK61.51312626
22PTK61.44089212
23PAK41.40301449
24ALK1.39864442
25FGFR41.36877892
26CDK71.32461686
27MTOR1.30622956
28MAP3K91.27258404
29KSR21.20668312
30CDC42BPA1.20645709
31BRD41.20225814
32SIK31.19695770
33MAP3K11.19036311
34IRAK41.18125033
35CLK11.16996145
36LRRK21.15864853
37MAP3K141.15478884
38MAP3K81.13342151
39TLK11.12552422
40TAOK11.11276158
41TNK21.10942153
42MAP3K31.08671478
43PRKD21.07766697
44SIK11.04349254
45TBK11.03029741
46MAP2K31.01673271
47STK40.99709449
48ARAF0.99190588
49DYRK30.97248436
50TTK0.95181705
51TESK20.94263448
52RPS6KB20.93723411
53RPS6KA40.93301860
54EPHB10.91429286
55PDPK10.88197519
56ZAP700.86664787
57CDK60.86520818
58IRAK20.85047877
59PASK0.83780800
60TAOK20.83313070
61CAMK1G0.82497734
62ATR0.82318195
63PAK20.81258262
64CSK0.80333287
65RIPK10.80217901
66TYK20.78538727
67CAMKK10.77743147
68CHEK10.76610853
69CDK90.75601882
70TTN0.74434176
71HIPK20.73969353
72MAPK120.72595561
73PIM10.72457025
74DYRK1B0.71711193
75HCK0.70953292
76CDK20.69683279
77PRKD30.69637597
78PDK10.68295143
79MAP3K110.68137725
80JAK30.67621294
81BTK0.66965084
82MAP3K60.64506942
83BRAF0.63753947
84PDGFRA0.63347171
85DDR20.62614262
86CHUK0.62501633
87MARK20.61362287
88CHEK20.59247295
89STK110.58674525
90MAPK110.58312073
91RPS6KC10.57628278
92RPS6KL10.57628278
93WEE10.56577906
94MST1R0.55941699
95STK380.55783558
96RPS6KA10.55725868
97KDR0.54971015
98BMX0.54320311
99CAMK1D0.54140976
100ILK0.54092039
101RPS6KA60.53345596
102TESK10.52436847
103RPS6KA20.52301292
104ATM0.51900339
105JAK10.51506178
106PTK20.50278596
107LATS20.50245032
108MAPK70.49023476
109IKBKE0.49009915
110EPHA20.48685098
111TAOK30.47057778
112BLK0.45574603
113DMPK0.44787909
114LCK0.43904964
115ITK0.42315969
116MAP2K20.41950322
117PRKG20.41914275
118SCYL20.41752840
119SGK30.41483058
120PLK10.41183050
121SYK0.41083262
122PNCK0.40815690
123DAPK10.40561979
124IKBKB0.40275103
125MAP3K70.39890319
126DAPK30.39818105
127RET0.39558385
128MOS0.38868071
129NME20.38462049
130CDK10.37634498
131PRKCH0.37154667
132PRKDC0.36985397
133FGFR30.36394374
134AURKB0.36267179
135* MAPK10.36248111
136MAPK40.36202936
137JAK20.35983184
138UHMK10.35926401
139MKNK20.35494811
140FES0.34684689

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.73821808
2Mismatch repair_Homo sapiens_hsa034302.39674765
3Spliceosome_Homo sapiens_hsa030402.26071803
4Base excision repair_Homo sapiens_hsa034102.20617136
5Primary immunodeficiency_Homo sapiens_hsa053402.18009428
6Other glycan degradation_Homo sapiens_hsa005112.17321666
7Notch signaling pathway_Homo sapiens_hsa043302.12485754
8Chronic myeloid leukemia_Homo sapiens_hsa052202.04636357
9Cell cycle_Homo sapiens_hsa041101.97002990
10mRNA surveillance pathway_Homo sapiens_hsa030151.95746783
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92846437
12B cell receptor signaling pathway_Homo sapiens_hsa046621.91058854
13Lysine degradation_Homo sapiens_hsa003101.82960392
14RNA transport_Homo sapiens_hsa030131.80933942
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67325112
16Acute myeloid leukemia_Homo sapiens_hsa052211.59101220
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57034587
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52411815
19Non-small cell lung cancer_Homo sapiens_hsa052231.47423572
20One carbon pool by folate_Homo sapiens_hsa006701.47261869
21T cell receptor signaling pathway_Homo sapiens_hsa046601.46380907
22HTLV-I infection_Homo sapiens_hsa051661.39787984
23Homologous recombination_Homo sapiens_hsa034401.39739621
24Small cell lung cancer_Homo sapiens_hsa052221.34158194
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33426257
26Nucleotide excision repair_Homo sapiens_hsa034201.32867629
27mTOR signaling pathway_Homo sapiens_hsa041501.32828002
28MicroRNAs in cancer_Homo sapiens_hsa052061.30895393
29TNF signaling pathway_Homo sapiens_hsa046681.28854984
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28722187
31VEGF signaling pathway_Homo sapiens_hsa043701.27718465
32Prion diseases_Homo sapiens_hsa050201.27592289
33Herpes simplex infection_Homo sapiens_hsa051681.26965511
34Antigen processing and presentation_Homo sapiens_hsa046121.26874853
35Ribosome_Homo sapiens_hsa030101.18846611
36Fanconi anemia pathway_Homo sapiens_hsa034601.16959351
37p53 signaling pathway_Homo sapiens_hsa041151.15662906
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13213932
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12998668
40Osteoclast differentiation_Homo sapiens_hsa043801.12757554
41Measles_Homo sapiens_hsa051621.11814595
42GnRH signaling pathway_Homo sapiens_hsa049121.10707703
43Pancreatic cancer_Homo sapiens_hsa052121.09126405
44Colorectal cancer_Homo sapiens_hsa052101.08563669
45Viral carcinogenesis_Homo sapiens_hsa052031.07795275
46Leishmaniasis_Homo sapiens_hsa051401.07190681
47Hepatitis B_Homo sapiens_hsa051611.06774576
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.05277451
49Hepatitis C_Homo sapiens_hsa051601.04643839
50Tuberculosis_Homo sapiens_hsa051521.03501747
51Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01092785
52Basal cell carcinoma_Homo sapiens_hsa052171.00853386
53* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.00609655
54Inositol phosphate metabolism_Homo sapiens_hsa005620.99863433
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.99259442
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.99041493
57Endometrial cancer_Homo sapiens_hsa052130.98119964
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97997722
59Glycosaminoglycan degradation_Homo sapiens_hsa005310.97587920
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96890531
61Viral myocarditis_Homo sapiens_hsa054160.95150425
62Long-term potentiation_Homo sapiens_hsa047200.94772704
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93655043
64Dorso-ventral axis formation_Homo sapiens_hsa043200.93018061
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.91066173
66Epstein-Barr virus infection_Homo sapiens_hsa051690.90453583
67Bladder cancer_Homo sapiens_hsa052190.88081776
68Sulfur relay system_Homo sapiens_hsa041220.87595109
69Toxoplasmosis_Homo sapiens_hsa051450.87530677
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.87166725
71Endocytosis_Homo sapiens_hsa041440.86444959
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86350646
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.85434577
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85428225
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85177604
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84921049
77Malaria_Homo sapiens_hsa051440.84884992
78Amoebiasis_Homo sapiens_hsa051460.84556316
79Glioma_Homo sapiens_hsa052140.83633110
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82538238
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.81997075
82Salmonella infection_Homo sapiens_hsa051320.81792656
83Selenocompound metabolism_Homo sapiens_hsa004500.81138680
84Oocyte meiosis_Homo sapiens_hsa041140.80387170
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.80288170
86Estrogen signaling pathway_Homo sapiens_hsa049150.78791784
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78442148
88Renal cell carcinoma_Homo sapiens_hsa052110.78263879
89Platelet activation_Homo sapiens_hsa046110.78237381
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78188822
91Thyroid cancer_Homo sapiens_hsa052160.77727653
92RNA degradation_Homo sapiens_hsa030180.76275203
93Prolactin signaling pathway_Homo sapiens_hsa049170.75726396
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.74039839
95Focal adhesion_Homo sapiens_hsa045100.74012045
96Proteoglycans in cancer_Homo sapiens_hsa052050.73929867
97Influenza A_Homo sapiens_hsa051640.72069506
98Hedgehog signaling pathway_Homo sapiens_hsa043400.71479233
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70958231
100Pathways in cancer_Homo sapiens_hsa052000.70920393
101Apoptosis_Homo sapiens_hsa042100.70466264
102Fructose and mannose metabolism_Homo sapiens_hsa000510.70331390
103Hippo signaling pathway_Homo sapiens_hsa043900.68527025
104Type II diabetes mellitus_Homo sapiens_hsa049300.68526911
105Insulin resistance_Homo sapiens_hsa049310.68304464
106FoxO signaling pathway_Homo sapiens_hsa040680.67542122
107Allograft rejection_Homo sapiens_hsa053300.65654098
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.63356139
109Pertussis_Homo sapiens_hsa051330.63230740
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63162238
111Choline metabolism in cancer_Homo sapiens_hsa052310.61942070
112Adherens junction_Homo sapiens_hsa045200.61773346
113Pentose phosphate pathway_Homo sapiens_hsa000300.61669145
114Wnt signaling pathway_Homo sapiens_hsa043100.61303582
115MAPK signaling pathway_Homo sapiens_hsa040100.61283765
116Prostate cancer_Homo sapiens_hsa052150.61143986
117TGF-beta signaling pathway_Homo sapiens_hsa043500.60976470
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60682838
119Chemokine signaling pathway_Homo sapiens_hsa040620.60317884
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58635457
121AMPK signaling pathway_Homo sapiens_hsa041520.58609765
122Hematopoietic cell lineage_Homo sapiens_hsa046400.58176134
123Shigellosis_Homo sapiens_hsa051310.57729843
124African trypanosomiasis_Homo sapiens_hsa051430.57591307
125Graft-versus-host disease_Homo sapiens_hsa053320.57500727
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57483331
127Rap1 signaling pathway_Homo sapiens_hsa040150.57399489
128Lysosome_Homo sapiens_hsa041420.57267732
129HIF-1 signaling pathway_Homo sapiens_hsa040660.55674857
130Autoimmune thyroid disease_Homo sapiens_hsa053200.54611743
131Staphylococcus aureus infection_Homo sapiens_hsa051500.54507892
132Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54422138
133Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54358651
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.51250411
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49887180
136ErbB signaling pathway_Homo sapiens_hsa040120.49112303
137Insulin signaling pathway_Homo sapiens_hsa049100.48862517

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