ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	leukotriene metabolic process (GO:0006691)	9.30609205
2	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	7.43022656
3	icosanoid biosynthetic process (GO:0046456)	7.11511313
4	fatty acid derivative biosynthetic process (GO:1901570)	7.11511313
5	neuronal action potential (GO:0019228)	6.86899487
6	cysteine metabolic process (GO:0006534)	6.81389727
7	glutathione metabolic process (GO:0006749)	6.54870374
8	unsaturated fatty acid biosynthetic process (GO:0006636)	6.15178689
9	bundle of His cell to Purkinje myocyte communication (GO:0086069)	5.87645926
10	peristalsis (GO:0030432)	4.83694204
11	mitochondrion distribution (GO:0048311)	4.73654464
12	behavioral response to nicotine (GO:0035095)	4.58443975
13	mitochondrial calcium ion transport (GO:0006851)	4.51426533
14	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	4.43980142
15	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	4.43980142
16	cerebellar Purkinje cell differentiation (GO:0021702)	4.08420712
17	protein K11-linked deubiquitination (GO:0035871)	4.01849734
18	cellular response to zinc ion (GO:0071294)	3.99999682
19	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.92827570
20	positive regulation of action potential (GO:0045760)	3.88287277
21	icosanoid metabolic process (GO:0006690)	3.75439500
22	fatty acid derivative metabolic process (GO:1901568)	3.75439500
23	membrane depolarization during action potential (GO:0086010)	3.74094972
24	positive regulation of endothelial cell differentiation (GO:0045603)	3.72598641
25	positive regulation of guanylate cyclase activity (GO:0031284)	3.71326597
26	urate metabolic process (GO:0046415)	3.64043354
27	postsynaptic membrane organization (GO:0001941)	3.57734387
28	dopamine transport (GO:0015872)	3.51206309
29	microglial cell activation (GO:0001774)	3.49455695
30	detection of molecule of bacterial origin (GO:0032490)	3.47955447
31	negative regulation of T cell receptor signaling pathway (GO:0050860)	3.44490427
32	positive regulation of cGMP biosynthetic process (GO:0030828)	3.40565084
33	fatty acid biosynthetic process (GO:0006633)	3.39796947
34	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.36888666
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.36711496
36	regulation of guanylate cyclase activity (GO:0031282)	3.34335809
37	axon ensheathment in central nervous system (GO:0032291)	3.33080592
38	central nervous system myelination (GO:0022010)	3.33080592
39	regulation of neurotransmitter uptake (GO:0051580)	3.32654276
40	tachykinin receptor signaling pathway (GO:0007217)	3.31237507
41	head development (GO:0060322)	3.30459490
42	action potential (GO:0001508)	3.28277720
43	unsaturated fatty acid metabolic process (GO:0033559)	3.25979106
44	GTP biosynthetic process (GO:0006183)	3.24074249
45	adaptation of signaling pathway (GO:0023058)	3.24048705
46	rhodopsin mediated signaling pathway (GO:0016056)	3.22101692
47	T cell migration (GO:0072678)	3.21474310
48	regulation of cGMP biosynthetic process (GO:0030826)	3.18821508
49	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	3.11551158
50	histone H2A acetylation (GO:0043968)	3.10907092
51	positive regulation of protein kinase C signaling (GO:0090037)	3.10881618
52	phasic smooth muscle contraction (GO:0014821)	3.08939751
53	protein ADP-ribosylation (GO:0006471)	3.07084486
54	cytokine biosynthetic process (GO:0042089)	3.04274680
55	phosphate ion transport (GO:0006817)	2.99890584
56	UTP biosynthetic process (GO:0006228)	2.94141873
57	regulation of hippo signaling (GO:0035330)	2.93012341
58	prepulse inhibition (GO:0060134)	2.92570990
59	positive regulation of cGMP metabolic process (GO:0030825)	2.91476347
60	serotonin metabolic process (GO:0042428)	2.91017280
61	cilium or flagellum-dependent cell motility (GO:0001539)	2.90737044
62	negative regulation of cAMP-mediated signaling (GO:0043951)	2.90222345
63	activated T cell proliferation (GO:0050798)	2.89847738
64	cell differentiation in hindbrain (GO:0021533)	2.82645871
65	toxin transport (GO:1901998)	2.81972059
66	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.81622629
67	negative regulation of execution phase of apoptosis (GO:1900118)	2.81527019
68	sulfur amino acid biosynthetic process (GO:0000097)	2.77399758
69	positive T cell selection (GO:0043368)	2.71939809
70	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.71407178
71	behavioral response to cocaine (GO:0048148)	2.70202971
72	regulation of endothelial cell differentiation (GO:0045601)	2.69382851
73	UTP metabolic process (GO:0046051)	2.66957529
74	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.66800639
75	catecholamine transport (GO:0051937)	2.65497329
76	oligosaccharide catabolic process (GO:0009313)	2.64752809
77	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.64242605
78	axonemal dynein complex assembly (GO:0070286)	2.63182976
79	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.63071700
80	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.60622745
81	peptide metabolic process (GO:0006518)	2.59099014
82	regulation of glucokinase activity (GO:0033131)	2.57802565
83	regulation of hexokinase activity (GO:1903299)	2.57802565
84	cytokine metabolic process (GO:0042107)	2.57698749
85	regulation of action potential (GO:0098900)	2.57363338
86	regulation of Golgi to plasma membrane protein transport (GO:0042996)	2.57264207
87	glutathione biosynthetic process (GO:0006750)	2.57128602
88	regulation of cGMP metabolic process (GO:0030823)	2.57069325
89	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.57049201
90	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.54791156
91	regulation of transcription involved in cell fate commitment (GO:0060850)	2.54093471
92	regulation of B cell receptor signaling pathway (GO:0050855)	2.53250066
93	maternal behavior (GO:0042711)	2.52563439
94	epithelial cilium movement (GO:0003351)	2.51739304
95	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.51254511
96	regulation of dopamine metabolic process (GO:0042053)	2.50754338
97	regulation of catecholamine metabolic process (GO:0042069)	2.50754338
98	regulation of defense response to virus by host (GO:0050691)	2.50542932
99	prenylation (GO:0097354)	2.49479904
100	leukotriene biosynthetic process (GO:0019370)	13.4259763

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.91685712
2	GATA1_22025678_ChIP-Seq_K562_Human	4.12349145
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.50741171
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.08674748
5	VDR_22108803_ChIP-Seq_LS180_Human	2.81934310
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.77998844
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.71037701
8	DROSHA_22980978_ChIP-Seq_HELA_Human	2.32568889
9	FUS_26573619_Chip-Seq_HEK293_Human	2.32094140
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.28381981
11	ER_23166858_ChIP-Seq_MCF-7_Human	2.04829664
12	P300_19829295_ChIP-Seq_ESCs_Human	2.02738035
13	AR_21572438_ChIP-Seq_LNCaP_Human	1.96465417
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.88998497
15	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.82922447
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.82423441
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.78615252
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.69762141
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.69673574
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.68769569
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66857843
22	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.64743037
23	EWS_26573619_Chip-Seq_HEK293_Human	1.59785192
24	BCAT_22108803_ChIP-Seq_LS180_Human	1.58146902
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57059251
26	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.54420489
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.54340181
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50451617
29	RUNX_20019798_ChIP-Seq_JUKART_Human	1.47867532
30	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.46133995
31	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.45248751
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.44526886
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44220433
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.43249210
35	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43199465
36	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.41020255
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40207575
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.40139253
39	STAT3_23295773_ChIP-Seq_U87_Human	1.40057562
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.38806985
41	AR_25329375_ChIP-Seq_VCAP_Human	1.36306861
42	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.35612278
43	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.34713305
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32195285
45	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.29179583
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29127373
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.28556337
48	RXR_22108803_ChIP-Seq_LS180_Human	1.28204763
49	CBP_20019798_ChIP-Seq_JUKART_Human	1.27786901
50	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27786901
51	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27285164
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25509347
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25509347
54	RUNX2_22187159_ChIP-Seq_PCA_Human	1.25471267
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24381305
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23223472
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.23223472
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22021727
59	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.19918575
60	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.17540242
61	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.17518401
62	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17392947
63	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.16961816
64	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.16090620
65	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.14584199
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.14369477
67	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.14158453
68	CDX2_22108803_ChIP-Seq_LS180_Human	1.13829863
69	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13821681
70	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.12750657
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12256200
72	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.11361023
73	OCT4_20526341_ChIP-Seq_ESCs_Human	1.11329236
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10572937
75	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10572937
76	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.10443704
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.10232834
78	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09570273
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09370550
80	NCOR_22424771_ChIP-Seq_293T_Human	1.06762222
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.06288320
82	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05352872
83	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05319772
84	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.05257316
85	HTT_18923047_ChIP-ChIP_STHdh_Human	1.04113815
86	TCF4_22108803_ChIP-Seq_LS180_Human	1.03954852
87	RNF2_27304074_Chip-Seq_NSC_Mouse	1.03098201
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02955443
89	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02623198
90	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.02310939
91	SMAD4_21799915_ChIP-Seq_A2780_Human	1.01214548
92	SCL_19346495_ChIP-Seq_HPC-7_Human	1.00912856
93	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.00873621
94	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.00456497
95	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00447682
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98793770
97	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.98185878
98	TP53_18474530_ChIP-ChIP_U2OS_Human	0.97828087
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97822806
100	SMRT_27268052_Chip-Seq_Bcells_Human	0.97755775

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.33375352
2	MP0002736_abnormal_nociception_after	4.85535323
3	MP0001968_abnormal_touch/_nociception	3.86213170
4	MP0003136_yellow_coat_color	3.30683142
5	MP0002822_catalepsy	2.92045425
6	MP0003195_calcinosis	2.87221828
7	MP0003183_abnormal_peptide_metabolism	2.78935231
8	MP0001501_abnormal_sleep_pattern	2.50817378
9	MP0005645_abnormal_hypothalamus_physiol	2.50310349
10	MP0002653_abnormal_ependyma_morphology	2.22949012
11	MP0002733_abnormal_thermal_nociception	2.17108574
12	MP0005551_abnormal_eye_electrophysiolog	2.15194242
13	MP0008995_early_reproductive_senescence	2.10716919
14	MP0005174_abnormal_tail_pigmentation	2.10261096
15	MP0005671_abnormal_response_to	1.97577564
16	MP0006276_abnormal_autonomic_nervous	1.93092113
17	MP0004133_heterotaxia	1.92751696
18	MP0002928_abnormal_bile_duct	1.87662873
19	MP0000613_abnormal_salivary_gland	1.87194826
20	MP0005220_abnormal_exocrine_pancreas	1.84444222
21	MP0002089_abnormal_postnatal_growth/wei	1.80310690
22	MP0000371_diluted_coat_color	1.79264551
23	MP0004043_abnormal_pH_regulation	1.78890582
24	MP0002163_abnormal_gland_morphology	1.72774538
25	MP0002277_abnormal_respiratory_mucosa	1.70264974
26	MP0003045_fibrosis	1.68991538
27	MP0000015_abnormal_ear_pigmentation	1.63579054
28	MP0008877_abnormal_DNA_methylation	1.62892712
29	MP0001970_abnormal_pain_threshold	1.62521209
30	MP0003300_gastrointestinal_ulcer	1.61584445
31	MP0002272_abnormal_nervous_system	1.56368595
32	MP0009379_abnormal_foot_pigmentation	1.53165926
33	MP0004142_abnormal_muscle_tone	1.47228427
34	MP0001545_abnormal_hematopoietic_system	1.42679323
35	MP0005397_hematopoietic_system_phenotyp	1.42679323
36	MP0001984_abnormal_olfaction	1.36770635
37	MP0002735_abnormal_chemical_nociception	1.29577848
38	MP0005379_endocrine/exocrine_gland_phen	1.29493643
39	MP0002067_abnormal_sensory_capabilities	1.23310907
40	MP0009745_abnormal_behavioral_response	1.21679000
41	MP0002572_abnormal_emotion/affect_behav	1.17269853
42	MP0009046_muscle_twitch	1.16701957
43	MP0008872_abnormal_physiological_respon	1.11278149
44	MP0006072_abnormal_retinal_apoptosis	1.10364438
45	MP0003635_abnormal_synaptic_transmissio	1.09703765
46	MP0002102_abnormal_ear_morphology	1.08819173
47	MP0003638_abnormal_response/metabolism_	1.06298702
48	MP0002095_abnormal_skin_pigmentation	1.04775025
49	MP0001905_abnormal_dopamine_level	1.03607497
50	MP0002751_abnormal_autonomic_nervous	1.02969157
51	MP0003786_premature_aging	1.02246030
52	MP0002063_abnormal_learning/memory/cond	1.00741192
53	MP0001502_abnormal_circadian_rhythm	1.00077451
54	MP0000372_irregular_coat_pigmentation	0.99478516
55	MP0003252_abnormal_bile_duct	0.99237831
56	MP0005253_abnormal_eye_physiology	0.99067317
57	MP0002229_neurodegeneration	0.98502894
58	MP0002638_abnormal_pupillary_reflex	0.94139144
59	MP0003646_muscle_fatigue	0.92936910
60	MP0004885_abnormal_endolymph	0.92588201
61	MP0001485_abnormal_pinna_reflex	0.90019910
62	MP0005332_abnormal_amino_acid	0.88521579
63	MP0003693_abnormal_embryo_hatching	0.88419078
64	MP0005389_reproductive_system_phenotype	0.88056126
65	MP0002734_abnormal_mechanical_nocicepti	0.87632476
66	MP0000678_abnormal_parathyroid_gland	0.87283068
67	MP0000470_abnormal_stomach_morphology	0.87124280
68	MP0010386_abnormal_urinary_bladder	0.87100904
69	MP0003698_abnormal_male_reproductive	0.86990529
70	MP0001790_abnormal_immune_system	0.86817622
71	MP0005387_immune_system_phenotype	0.86817622
72	MP0009785_altered_susceptibility_to	0.86741605
73	MP0004808_abnormal_hematopoietic_stem	0.86074314
74	MP0005646_abnormal_pituitary_gland	0.85970533
75	MP0001986_abnormal_taste_sensitivity	0.84967293
76	MP0003959_abnormal_lean_body	0.84179151
77	MP0004085_abnormal_heartbeat	0.80889995
78	MP0003763_abnormal_thymus_physiology	0.75783478
79	MP0002557_abnormal_social/conspecific_i	0.75769040
80	MP0001963_abnormal_hearing_physiology	0.75714014
81	MP0002160_abnormal_reproductive_system	0.73696531
82	MP0001800_abnormal_humoral_immune	0.73434372
83	MP0001929_abnormal_gametogenesis	0.72401661
84	MP0002064_seizures	0.71125258
85	MP0001765_abnormal_ion_homeostasis	0.70922516
86	MP0000631_abnormal_neuroendocrine_gland	0.70525824
87	MP0000653_abnormal_sex_gland	0.69950710
88	MP0002075_abnormal_coat/hair_pigmentati	0.69762991
89	MP0005083_abnormal_biliary_tract	0.66483837
90	MP0001486_abnormal_startle_reflex	0.66396506
91	MP0004130_abnormal_muscle_cell	0.65735404
92	MP0000534_abnormal_ureter_morphology	0.65242807
93	MP0002405_respiratory_system_inflammati	0.61595345
94	MP0008058_abnormal_DNA_repair	0.61108425
95	MP0003632_abnormal_nervous_system	0.59540934
96	MP0005195_abnormal_posterior_eye	0.59511298
97	MP0005377_hearing/vestibular/ear_phenot	0.59457179
98	MP0003878_abnormal_ear_physiology	0.59457179
99	MP0005075_abnormal_melanosome_morpholog	0.58012252
100	MP0000230_abnormal_systemic_arterial	0.57407654

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	6.08053075
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.21985845
3	Absent/shortened dynein arms (HP:0200106)	5.21985845
4	Generalized aminoaciduria (HP:0002909)	5.10847611
5	Pancreatic cysts (HP:0001737)	5.01288315
6	True hermaphroditism (HP:0010459)	4.73959950
7	Pancreatic fibrosis (HP:0100732)	4.54669130
8	Abnormality of the renal collecting system (HP:0004742)	3.73808789
9	Abnormal respiratory motile cilium morphology (HP:0005938)	3.62944188
10	Abnormal respiratory epithelium morphology (HP:0012253)	3.62944188
11	Duplicated collecting system (HP:0000081)	3.41615022
12	Cystic liver disease (HP:0006706)	3.36751612
13	Abnormal biliary tract physiology (HP:0012439)	3.34581676
14	Bile duct proliferation (HP:0001408)	3.34581676
15	Abnormal ciliary motility (HP:0012262)	3.34120961
16	Pendular nystagmus (HP:0012043)	3.12121437
17	Congenital sensorineural hearing impairment (HP:0008527)	2.96264323
18	Clumsiness (HP:0002312)	2.95673233
19	Severe visual impairment (HP:0001141)	2.89774544
20	Abnormality of DNA repair (HP:0003254)	2.82177018
21	J-shaped sella turcica (HP:0002680)	2.78217135
22	Abnormal respiratory motile cilium physiology (HP:0012261)	2.74443170
23	Male pseudohermaphroditism (HP:0000037)	2.60676389
24	Impaired smooth pursuit (HP:0007772)	2.58878919
25	Hyperkalemia (HP:0002153)	2.55823304
26	Carpal bone hypoplasia (HP:0001498)	2.53239582
27	Furrowed tongue (HP:0000221)	2.51835699
28	Type II lissencephaly (HP:0007260)	2.48090907
29	Abolished electroretinogram (ERG) (HP:0000550)	2.47486218
30	Sclerocornea (HP:0000647)	2.42624261
31	Vacuolated lymphocytes (HP:0001922)	2.41330936
32	Optic nerve hypoplasia (HP:0000609)	2.40620709
33	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36915884
34	Enlarged epiphyses (HP:0010580)	2.36075712
35	Clubbing of toes (HP:0100760)	2.35119079
36	Palpebral edema (HP:0100540)	2.32366155
37	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.31352702
38	Attenuation of retinal blood vessels (HP:0007843)	2.31066644
39	Thyroiditis (HP:0100646)	2.30904776
40	Generalized hypopigmentation of hair (HP:0011358)	2.29488738
41	Supernumerary spleens (HP:0009799)	2.27879856
42	Febrile seizures (HP:0002373)	2.26739364
43	Hypoplasia of the fovea (HP:0007750)	2.22397792
44	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.22397792
45	Peritonitis (HP:0002586)	2.20482455
46	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.17589289
47	Gastrointestinal infarctions (HP:0005244)	2.17500006
48	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14160186
49	Nephronophthisis (HP:0000090)	2.13548515
50	Molar tooth sign on MRI (HP:0002419)	2.13459572
51	Abnormality of midbrain morphology (HP:0002418)	2.13459572
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.12695677
53	Nonprogressive disorder (HP:0003680)	2.11676371
54	Abnormality of the costochondral junction (HP:0000919)	2.11207685
55	Azoospermia (HP:0000027)	2.09515291
56	Abnormality of chloride homeostasis (HP:0011422)	2.09506371
57	Nonimmune hydrops fetalis (HP:0001790)	2.05946630
58	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.02541515
59	Hypokalemic alkalosis (HP:0001949)	2.02407420
60	Postaxial foot polydactyly (HP:0001830)	2.02353181
61	Congenital hepatic fibrosis (HP:0002612)	2.00717559
62	Beaking of vertebral bodies (HP:0004568)	2.00458111
63	Anencephaly (HP:0002323)	1.97770411
64	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.97130338
65	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.96692098
66	Constricted visual fields (HP:0001133)	1.93896716
67	Protuberant abdomen (HP:0001538)	1.93298150
68	Fair hair (HP:0002286)	1.91110889
69	Chronic sinusitis (HP:0011109)	1.90527943
70	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.90172657
71	Chronic hepatic failure (HP:0100626)	1.90140856
72	Global brain atrophy (HP:0002283)	1.88928383
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.88800170
74	Aplasia/Hypoplasia of the macula (HP:0008059)	1.88593791
75	Decreased circulating renin level (HP:0003351)	1.88155204
76	Thoracolumbar scoliosis (HP:0002944)	1.87214113
77	Glycosuria (HP:0003076)	1.86875790
78	Abnormality of urine glucose concentration (HP:0011016)	1.86875790
79	Hypothermia (HP:0002045)	1.86665847
80	Failure to thrive in infancy (HP:0001531)	1.85866434
81	Concave nail (HP:0001598)	1.85315765
82	Abnormality of the fovea (HP:0000493)	1.84407512
83	Severe global developmental delay (HP:0011344)	1.83447037
84	Abnormality of chromosome stability (HP:0003220)	1.81976160
85	Hepatic necrosis (HP:0002605)	1.81423931
86	Severe combined immunodeficiency (HP:0004430)	1.80402974
87	T lymphocytopenia (HP:0005403)	1.80374287
88	Abnormality of T cell number (HP:0011839)	1.80309893
89	Genetic anticipation (HP:0003743)	1.79919242
90	Visual hallucinations (HP:0002367)	1.77975859
91	Abnormal spermatogenesis (HP:0008669)	1.77505487
92	IgM deficiency (HP:0002850)	1.76408447
93	Progressive cerebellar ataxia (HP:0002073)	1.76112964
94	Abnormality of the renal medulla (HP:0100957)	1.75918467
95	Nausea (HP:0002018)	1.74508533
96	Limb dystonia (HP:0002451)	1.74465831
97	Infertility (HP:0000789)	1.74168058
98	Proximal tubulopathy (HP:0000114)	1.73856864
99	Alkalosis (HP:0001948)	1.73469107
100	Abnormality of ocular smooth pursuit (HP:0000617)	1.73128036

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	6.82064459
2	ADRBK2	3.96255508
3	GRK1	3.29578222
4	BLK	3.27713116
5	MAP4K1	3.25538936
6	FRK	3.06923103
7	MAPK15	2.61580981
8	MAP3K11	2.53557283
9	KDR	2.21270327
10	IKBKE	1.85092510
11	NTRK3	1.83203104
12	PINK1	1.82874389
13	TXK	1.81624679
14	WNK4	1.76661203
15	GRK5	1.68274501
16	GRK7	1.65907749
17	MAP3K2	1.65408338
18	TIE1	1.56604718
19	PTK2B	1.54366046
20	PIK3CG	1.50916041
21	NTRK2	1.36579900
22	SYK	1.33038735
23	ZAP70	1.32884361
24	TLK1	1.30955690
25	MAPK13	1.29087385
26	MAP3K13	1.28459667
27	UHMK1	1.23926557
28	TBK1	1.19543785
29	WEE1	1.14804263
30	TNK2	1.13865726
31	DAPK2	1.13775645
32	ADRBK1	1.13371085
33	CAMKK2	1.10745438
34	FES	1.07395685
35	KSR1	1.05050749
36	MAP3K5	1.01596181
37	HIPK2	0.99024390
38	PNCK	0.98594024
39	DYRK2	0.96990921
40	FGFR3	0.95658071
41	TESK2	0.91841390
42	ACVR1B	0.90013208
43	CASK	0.86740940
44	FGR	0.86090686
45	ZAK	0.83858560
46	MAP3K1	0.83426460
47	JAK3	0.82629533
48	BRSK2	0.81457488
49	LYN	0.79705957
50	PIM1	0.75031097
51	CAMK4	0.74639630
52	TGFBR2	0.72777129
53	IKBKB	0.68273817
54	DYRK1A	0.66333580
55	CAMK2B	0.65713141
56	FGFR2	0.64692239
57	WNK3	0.64603152
58	PRKCI	0.62992859
59	LCK	0.61694703
60	WNK1	0.59348868
61	INSRR	0.57220676
62	CAMKK1	0.55821077
63	CSK	0.55598826
64	MAP2K2	0.55128306
65	DYRK3	0.54030209
66	MAP3K7	0.53974055
67	MAP3K14	0.53514059
68	GRK6	0.53090046
69	CAMK2A	0.51787335
70	CSNK1A1	0.50525019
71	MARK3	0.49656577
72	ITK	0.48634351
73	OBSCN	0.47872829
74	IRAK1	0.47256886
75	MAP2K1	0.47117090
76	LATS1	0.44516843
77	BMPR1B	0.43987920
78	TYRO3	0.43724461
79	CSF1R	0.42696033
80	DDR2	0.39807465
81	MOS	0.39586447
82	RPS6KA5	0.39438893
83	PRKCZ	0.39206675
84	TEC	0.39035440
85	MATK	0.38468097
86	RIPK4	0.37748798
87	INSR	0.37669914
88	IRAK4	0.37350828
89	SCYL2	0.36679424
90	RPS6KA6	0.35260418
91	STK38L	0.34054378
92	CHUK	0.31098429
93	PRKACA	0.31085101
94	SIK2	0.28951441
95	PRKG1	0.26855101
96	SGK1	0.25801155
97	STK11	0.24292429
98	AURKA	0.23941232
99	BTK	0.23826042
100	MAPK3	0.23739614

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cyanoamino acid metabolism_Homo sapiens_hsa00460	7.36932835
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	5.15303765
3	Phototransduction_Homo sapiens_hsa04744	3.56459431
4	Nicotine addiction_Homo sapiens_hsa05033	2.94971236
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.89498879
6	Taste transduction_Homo sapiens_hsa04742	2.83638484
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24895848
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08537932
9	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97023141
10	Morphine addiction_Homo sapiens_hsa05032	1.88844888
11	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.75712252
12	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.61216031
13	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.58171879
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.54318478
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.49281391
16	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.45299254
17	GABAergic synapse_Homo sapiens_hsa04727	1.42976980
18	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.40284161
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.34447404
20	Ether lipid metabolism_Homo sapiens_hsa00565	1.32303065
21	Cocaine addiction_Homo sapiens_hsa05030	1.28232809
22	Olfactory transduction_Homo sapiens_hsa04740	1.26567703
23	Serotonergic synapse_Homo sapiens_hsa04726	1.26041031
24	Selenocompound metabolism_Homo sapiens_hsa00450	1.22308302
25	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.15945237
26	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.14142175
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.11687346
28	Mineral absorption_Homo sapiens_hsa04978	1.09599730
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.08383971
30	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.05385679
31	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.00236463
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.99110667
33	Renin secretion_Homo sapiens_hsa04924	0.98379075
34	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96023379
35	Chemical carcinogenesis_Homo sapiens_hsa05204	0.88147162
36	Glutathione metabolism_Homo sapiens_hsa00480	0.86233909
37	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.85315092
38	Amphetamine addiction_Homo sapiens_hsa05031	0.84681218
39	Histidine metabolism_Homo sapiens_hsa00340	0.84180689
40	Calcium signaling pathway_Homo sapiens_hsa04020	0.82424434
41	Salivary secretion_Homo sapiens_hsa04970	0.79542199
42	Retinol metabolism_Homo sapiens_hsa00830	0.78839223
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78784811
44	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.78519880
45	Circadian entrainment_Homo sapiens_hsa04713	0.78401108
46	Antigen processing and presentation_Homo sapiens_hsa04612	0.76625506
47	Parkinsons disease_Homo sapiens_hsa05012	0.76461114
48	Other glycan degradation_Homo sapiens_hsa00511	0.72868467
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.71798777
50	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.67950958
51	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.66262209
52	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.65690890
53	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.61966299
54	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.61336677
55	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.60376192
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.58690306
57	Renin-angiotensin system_Homo sapiens_hsa04614	0.57344789
58	Cholinergic synapse_Homo sapiens_hsa04725	0.54500183
59	Butanoate metabolism_Homo sapiens_hsa00650	0.53176265
60	Sulfur relay system_Homo sapiens_hsa04122	0.52484481
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50918738
62	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48395463
63	Alzheimers disease_Homo sapiens_hsa05010	0.47382888
64	Oxidative phosphorylation_Homo sapiens_hsa00190	0.45973580
65	Bile secretion_Homo sapiens_hsa04976	0.45891514
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43124760
67	Tuberculosis_Homo sapiens_hsa05152	0.42678913
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.42574914
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42325944
70	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.41426454
71	MAPK signaling pathway_Homo sapiens_hsa04010	0.41073811
72	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.40697226
73	Chemokine signaling pathway_Homo sapiens_hsa04062	0.40476463
74	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.39980347
75	Caffeine metabolism_Homo sapiens_hsa00232	0.39933046
76	Alcoholism_Homo sapiens_hsa05034	0.39348896
77	Cardiac muscle contraction_Homo sapiens_hsa04260	0.38537581
78	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.37721212
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37316933
80	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.37311153
81	Leishmaniasis_Homo sapiens_hsa05140	0.36480209
82	Non-homologous end-joining_Homo sapiens_hsa03450	0.36288767
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34245087
84	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.33944850
85	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.33601216
86	Circadian rhythm_Homo sapiens_hsa04710	0.32231344
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31055174
88	Allograft rejection_Homo sapiens_hsa05330	0.31046887
89	Huntingtons disease_Homo sapiens_hsa05016	0.29409016
90	PPAR signaling pathway_Homo sapiens_hsa03320	0.29035117
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.28898843
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28781134
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28524244
94	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.25587531
95	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.24815117
96	African trypanosomiasis_Homo sapiens_hsa05143	0.23794751
97	One carbon pool by folate_Homo sapiens_hsa00670	0.21722004
98	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.20369272
99	Steroid biosynthesis_Homo sapiens_hsa00100	0.18871023
100	ABC transporters_Homo sapiens_hsa02010	0.18687095

REXO1L12P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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