ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intestinal cholesterol absorption (GO:0030299)	7.85586296
2	regulation of transmission of nerve impulse (GO:0051969)	7.57189038
3	fusion of sperm to egg plasma membrane (GO:0007342)	7.31067407
4	piRNA metabolic process (GO:0034587)	5.97564824
5	response to pheromone (GO:0019236)	5.90433243
6	plasma membrane fusion (GO:0045026)	5.86764181
7	positive regulation of action potential (GO:0045760)	5.21534892
8	positive regulation of catecholamine secretion (GO:0033605)	5.15742497
9	negative regulation of response to food (GO:0032096)	5.09220286
10	negative regulation of appetite (GO:0032099)	5.09220286
11	adult feeding behavior (GO:0008343)	5.00922674
12	regulation of posttranscriptional gene silencing (GO:0060147)	4.57756860
13	regulation of gene silencing by miRNA (GO:0060964)	4.57756860
14	regulation of gene silencing by RNA (GO:0060966)	4.57756860
15	cilium or flagellum-dependent cell motility (GO:0001539)	4.41896239
16	organic cation transport (GO:0015695)	4.38103318
17	regulation of cytokine production involved in inflammatory response (GO:1900015)	4.18379397
18	phosphatidylinositol acyl-chain remodeling (GO:0036149)	4.13135237
19	regulation of acrosome reaction (GO:0060046)	4.12201658
20	regulation of rhodopsin mediated signaling pathway (GO:0022400)	4.09510370
21	NIK/NF-kappaB signaling (GO:0038061)	4.08489588
22	ribosomal small subunit assembly (GO:0000028)	4.08236219
23	positive regulation of neurological system process (GO:0031646)	4.05352677
24	neuronal action potential (GO:0019228)	4.04568294
25	negative regulation of bone resorption (GO:0045779)	4.04103507
26	phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)	3.97428872
27	motile cilium assembly (GO:0044458)	3.93140091
28	indolalkylamine metabolic process (GO:0006586)	3.91351552
29	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.87827945
30	cellular response to exogenous dsRNA (GO:0071360)	3.83992850
31	seminiferous tubule development (GO:0072520)	3.81630436
32	histamine secretion (GO:0001821)	3.77176909
33	rhodopsin mediated signaling pathway (GO:0016056)	3.71228577
34	male meiosis I (GO:0007141)	3.64694291
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.64127145
36	post-embryonic morphogenesis (GO:0009886)	3.61632806
37	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	3.53541154
38	sulfation (GO:0051923)	3.49269935
39	indole-containing compound metabolic process (GO:0042430)	3.43583943
40	digestion (GO:0007586)	3.43297135
41	tryptophan metabolic process (GO:0006568)	3.42924454
42	transmission of nerve impulse (GO:0019226)	3.36538463
43	protein K48-linked deubiquitination (GO:0071108)	3.33917935
44	fucose catabolic process (GO:0019317)	3.33367496
45	L-fucose metabolic process (GO:0042354)	3.33367496
46	L-fucose catabolic process (GO:0042355)	3.33367496
47	regulation of appetite (GO:0032098)	3.30772270
48	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.24796251
49	long term synaptic depression (GO:0060292)	3.22942089
50	synaptic transmission, dopaminergic (GO:0001963)	3.21511284
51	regulation of action potential (GO:0098900)	3.21236069
52	fat-soluble vitamin biosynthetic process (GO:0042362)	3.18006461
53	negative regulation of bone remodeling (GO:0046851)	3.15050176
54	sperm motility (GO:0030317)	3.10000243
55	axoneme assembly (GO:0035082)	3.09223778
56	epithelial cilium movement (GO:0003351)	3.05128454
57	GTP biosynthetic process (GO:0006183)	3.04358537
58	DNA methylation involved in gamete generation (GO:0043046)	3.04085964
59	regulation of response to food (GO:0032095)	3.01379439
60	multicellular organism reproduction (GO:0032504)	2.98797627
61	peristalsis (GO:0030432)	2.98108621
62	cell wall macromolecule metabolic process (GO:0044036)	2.97217859
63	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.94906466
64	phosphatidylethanolamine acyl-chain remodeling (GO:0036152)	2.89981796
65	cilium movement (GO:0003341)	2.88169301
66	regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)	2.85591683
67	histamine transport (GO:0051608)	2.84823778
68	DNA damage response, detection of DNA damage (GO:0042769)	2.82135003
69	histone H3-K9 methylation (GO:0051567)	2.80154672
70	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	2.79360998
71	intestinal absorption (GO:0050892)	2.77826526
72	oogenesis (GO:0048477)	2.77614768
73	cell morphogenesis involved in neuron differentiation (GO:0048667)	2.77317020
74	ribosomal large subunit biogenesis (GO:0042273)	2.75413880
75	meiosis I (GO:0007127)	2.75199741
76	regulation of RIG-I signaling pathway (GO:0039535)	2.74436446
77	imidazole-containing compound metabolic process (GO:0052803)	2.71669398
78	dopamine transport (GO:0015872)	2.70559613
79	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.69940712
80	detection of light stimulus involved in sensory perception (GO:0050962)	2.68760126
81	detection of light stimulus involved in visual perception (GO:0050908)	2.68760126
82	acrosome reaction (GO:0007340)	2.67748149
83	regulation of ruffle assembly (GO:1900027)	2.65355898
84	protein polyglutamylation (GO:0018095)	2.64942124
85	I-kappaB phosphorylation (GO:0007252)	2.63930198
86	histone H3-K9 modification (GO:0061647)	2.62051102
87	G-protein coupled receptor internalization (GO:0002031)	2.58887594
88	behavioral response to nicotine (GO:0035095)	2.56210032
89	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.54908903
90	negative regulation of gene silencing (GO:0060969)	2.52307268
91	termination of G-protein coupled receptor signaling pathway (GO:0038032)	2.51960306
92	B cell receptor signaling pathway (GO:0050853)	2.51405067
93	establishment of protein localization to Golgi (GO:0072600)	2.50851702
94	UTP biosynthetic process (GO:0006228)	2.49212709
95	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.48968843
96	macroautophagy (GO:0016236)	2.47702248
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.47638151
98	NADH dehydrogenase complex assembly (GO:0010257)	2.47638151
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.47638151
100	negative regulation of sodium ion transport (GO:0010766)	2.47507310

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.65126243
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.53861369
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.78872703
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.72499431
5	* VDR_22108803_ChIP-Seq_LS180_Human	3.40523894
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.27906526
7	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.91215269
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.88558113
9	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.49973899
10	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.42718996
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.22411557
12	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17866841
13	ZNF274_21170338_ChIP-Seq_K562_Hela	2.16274332
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.11355567
15	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01616147
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.97799958
17	FUS_26573619_Chip-Seq_HEK293_Human	1.90403882
18	DROSHA_22980978_ChIP-Seq_HELA_Human	1.87402759
19	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.81004908
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.77217561
21	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.64059977
22	* ER_23166858_ChIP-Seq_MCF-7_Human	1.61520384
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60085428
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.59419173
25	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.58221916
26	* P300_19829295_ChIP-Seq_ESCs_Human	1.52432190
27	EWS_26573619_Chip-Seq_HEK293_Human	1.48920737
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47299218
29	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.44429612
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.44429612
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.39670880
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.33687985
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.32176294
34	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30300510
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30300510
36	STAT3_23295773_ChIP-Seq_U87_Human	1.28962193
37	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.28623866
38	AR_20517297_ChIP-Seq_VCAP_Human	1.27993302
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.27782058
40	ERG_20517297_ChIP-Seq_VCAP_Human	1.25497075
41	OCT4_20526341_ChIP-Seq_ESCs_Human	1.25377670
42	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24023279
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24023279
44	AR_25329375_ChIP-Seq_VCAP_Human	1.21703166
45	ETV1_20927104_ChIP-Seq_GIST48_Human	1.21686082
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.21681144
47	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18372663
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.18284784
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17759591
50	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17278622
51	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.14951154
52	TCF4_23295773_ChIP-Seq_U87_Human	1.14052841
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.13937417
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.13397636
55	RAC3_21632823_ChIP-Seq_H3396_Human	1.12282035
56	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.12139850
57	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.11331285
58	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.10928651
59	NFYB_21822215_ChIP-Seq_K562_Human	1.10837110
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.10341403
61	NCOR_22424771_ChIP-Seq_293T_Human	1.10141412
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.09710937
63	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09259306
64	NFYA_21822215_ChIP-Seq_K562_Human	1.08349083
65	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.08219949
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07029865
67	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06949800
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.05376062
69	PHF8_20622853_ChIP-Seq_HELA_Human	1.05064486
70	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.04643416
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04467621
72	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04251664
73	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.03891222
74	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.03036764
75	CEBPB_22108803_ChIP-Seq_LS180_Human	1.02843383
76	* BCAT_22108803_ChIP-Seq_LS180_Human	1.02757352
77	AR_21572438_ChIP-Seq_LNCaP_Human	1.02724231
78	TBL1_22424771_ChIP-Seq_293T_Human	1.02319457
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02282289
80	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.02275559
81	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.00728760
82	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00304661
83	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00288286
84	RBPJ_21746931_ChIP-Seq_IB4_Human	1.00208412
85	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98530652
86	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.97837738
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97793456
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97081384
89	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.96689503
90	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.95928742
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.95507192
92	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94995740
93	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.94680136
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93201321
95	* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.93046090
96	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.92556309
97	EGR1_19032775_ChIP-ChIP_M12_Human	0.92363510
98	GATA3_26560356_Chip-Seq_TH2_Human	0.92155539
99	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.91908724
100	* HOXB7_26014856_ChIP-Seq_BT474_Human	0.91810648

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001666_abnormal_nutrient_absorption	3.35370034
2	MP0005410_abnormal_fertilization	3.24529132
3	MP0003878_abnormal_ear_physiology	3.06265254
4	MP0005377_hearing/vestibular/ear_phenot	3.06265254
5	MP0005551_abnormal_eye_electrophysiolog	2.90932832
6	MP0005365_abnormal_bile_salt	2.86549441
7	MP0006072_abnormal_retinal_apoptosis	2.79888190
8	MP0003806_abnormal_nucleotide_metabolis	2.65833496
9	MP0002138_abnormal_hepatobiliary_system	2.60838067
10	MP0003950_abnormal_plasma_membrane	2.50771054
11	MP0001968_abnormal_touch/_nociception	2.40725738
12	MP0003283_abnormal_digestive_organ	2.15676819
13	MP0002332_abnormal_exercise_endurance	1.99862090
14	MP0005253_abnormal_eye_physiology	1.93173091
15	MP0006292_abnormal_olfactory_placode	1.92550790
16	MP0005670_abnormal_white_adipose	1.92098963
17	MP0003195_calcinosis	1.87634149
18	MP0003959_abnormal_lean_body	1.79307155
19	MP0003183_abnormal_peptide_metabolism	1.74986490
20	MP0002095_abnormal_skin_pigmentation	1.73547753
21	MP0005085_abnormal_gallbladder_physiolo	1.72475097
22	MP0001293_anophthalmia	1.68958328
23	MP0008875_abnormal_xenobiotic_pharmacok	1.68923787
24	MP0003879_abnormal_hair_cell	1.66979422
25	MP0003136_yellow_coat_color	1.66313437
26	MP0005448_abnormal_energy_balance	1.62005056
27	MP0010386_abnormal_urinary_bladder	1.59940788
28	MP0006276_abnormal_autonomic_nervous	1.58233005
29	MP0009745_abnormal_behavioral_response	1.57277088
30	MP0003646_muscle_fatigue	1.56687305
31	MP0005075_abnormal_melanosome_morpholog	1.56410379
32	MP0008877_abnormal_DNA_methylation	1.55804187
33	MP0003698_abnormal_male_reproductive	1.53506491
34	MP0001790_abnormal_immune_system	1.51597612
35	MP0005387_immune_system_phenotype	1.51597612
36	MP0002736_abnormal_nociception_after	1.47141375
37	MP0009379_abnormal_foot_pigmentation	1.46569641
38	MP0001485_abnormal_pinna_reflex	1.41234414
39	MP0001486_abnormal_startle_reflex	1.41129686
40	MP0001986_abnormal_taste_sensitivity	1.39041021
41	MP0001929_abnormal_gametogenesis	1.36349543
42	MP0002102_abnormal_ear_morphology	1.36187632
43	MP0002229_neurodegeneration	1.36020788
44	MP0003011_delayed_dark_adaptation	1.30946799
45	MP0002272_abnormal_nervous_system	1.30480692
46	MP0000465_gastrointestinal_hemorrhage	1.29645704
47	MP0002067_abnormal_sensory_capabilities	1.28618109
48	MP0005266_abnormal_metabolism	1.28222996
49	MP0002572_abnormal_emotion/affect_behav	1.24620627
50	MP0002928_abnormal_bile_duct	1.24458714
51	MP0002693_abnormal_pancreas_physiology	1.23475429
52	MP0003868_abnormal_feces_composition	1.23410588
53	MP0005671_abnormal_response_to	1.19919790
54	MP0001664_abnormal_digestion	1.17059462
55	MP0008872_abnormal_physiological_respon	1.15763142
56	MP0004147_increased_porphyrin_level	1.14334879
57	MP0002210_abnormal_sex_determination	1.13375764
58	MP0008995_early_reproductive_senescence	1.13327539
59	MP0005503_abnormal_tendon_morphology	1.12571478
60	MP0002064_seizures	1.11310604
61	MP0004885_abnormal_endolymph	1.10434905
62	MP0002837_dystrophic_cardiac_calcinosis	1.09800073
63	MP0004043_abnormal_pH_regulation	1.06857806
64	MP0000427_abnormal_hair_cycle	1.05119166
65	MP0005171_absent_coat_pigmentation	1.02315836
66	MP0005645_abnormal_hypothalamus_physiol	1.01941014
67	MP0005391_vision/eye_phenotype	1.01052226
68	MP0002909_abnormal_adrenal_gland	1.00962805
69	MP0005195_abnormal_posterior_eye	1.00169006
70	MP0002734_abnormal_mechanical_nocicepti	0.99732010
71	MP0000372_irregular_coat_pigmentation	0.98845267
72	MP0001873_stomach_inflammation	0.98771858
73	MP0005310_abnormal_salivary_gland	0.98378856
74	MP0002876_abnormal_thyroid_physiology	0.97998866
75	MP0005084_abnormal_gallbladder_morpholo	0.97925948
76	MP0002733_abnormal_thermal_nociception	0.95803478
77	MP0002557_abnormal_social/conspecific_i	0.93468453
78	MP0010329_abnormal_lipoprotein_level	0.93456188
79	MP0009643_abnormal_urine_homeostasis	0.92308821
80	MP0001970_abnormal_pain_threshold	0.90867985
81	MP0001145_abnormal_male_reproductive	0.90800235
82	MP0005167_abnormal_blood-brain_barrier	0.90536580
83	MP0003172_abnormal_lysosome_physiology	0.88286417
84	MP0003941_abnormal_skin_development	0.87618729
85	MP0003137_abnormal_impulse_conducting	0.86264653
86	MP0000653_abnormal_sex_gland	0.86240931
87	MP0004019_abnormal_vitamin_homeostasis	0.85100358
88	MP0001765_abnormal_ion_homeostasis	0.84626035
89	MP0003252_abnormal_bile_duct	0.83665784
90	MP0003635_abnormal_synaptic_transmissio	0.82003343
91	MP0005174_abnormal_tail_pigmentation	0.81115076
92	MP0002139_abnormal_hepatobiliary_system	0.80412264
93	MP0000538_abnormal_urinary_bladder	0.79923680
94	MP0008004_abnormal_stomach_pH	0.78742578
95	MP0003567_abnormal_fetal_cardiomyocyte	0.76854858
96	MP0001879_abnormal_lymphatic_vessel	0.76192834
97	MP0002638_abnormal_pupillary_reflex	0.75474789
98	MP0002136_abnormal_kidney_physiology	0.75411283
99	MP0005535_abnormal_body_temperature	0.75003948
100	MP0000681_abnormal_thyroid_gland	0.71394551

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Dynein arm defect of respiratory motile cilia (HP:0012255)	8.41607050
2	Absent/shortened dynein arms (HP:0200106)	8.41607050
3	Congenital stationary night blindness (HP:0007642)	5.42021647
4	Abnormal ciliary motility (HP:0012262)	5.33636716
5	Chronic hepatic failure (HP:0100626)	5.27311862
6	Protruding tongue (HP:0010808)	4.99620868
7	Atonic seizures (HP:0010819)	4.86645739
8	Agammaglobulinemia (HP:0004432)	4.80310392
9	Abnormal respiratory epithelium morphology (HP:0012253)	4.75286594
10	Abnormal respiratory motile cilium morphology (HP:0005938)	4.75286594
11	Abnormal respiratory motile cilium physiology (HP:0012261)	3.88305510
12	Tubulointerstitial nephritis (HP:0001970)	3.67444911
13	Hemiplegia (HP:0002301)	3.42851136
14	Pancreatic cysts (HP:0001737)	3.39347192
15	Abolished electroretinogram (ERG) (HP:0000550)	3.32696484
16	Infantile muscular hypotonia (HP:0008947)	3.29814127
17	Congenital sensorineural hearing impairment (HP:0008527)	3.27015028
18	Panhypogammaglobulinemia (HP:0003139)	3.24376709
19	Molar tooth sign on MRI (HP:0002419)	3.23795259
20	Abnormality of midbrain morphology (HP:0002418)	3.23795259
21	Agitation (HP:0000713)	3.21438174
22	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.17812738
23	Chronic otitis media (HP:0000389)	3.12374876
24	3-Methylglutaconic aciduria (HP:0003535)	3.03136537
25	Abnormality of the prostate (HP:0008775)	3.00228202
26	Attenuation of retinal blood vessels (HP:0007843)	2.93708899
27	Abnormality of the right ventricle (HP:0001707)	2.90409469
28	Persistence of primary teeth (HP:0006335)	2.89030103
29	Delayed CNS myelination (HP:0002188)	2.79974627
30	Hyperventilation (HP:0002883)	2.73783334
31	Clumsiness (HP:0002312)	2.73643210
32	Chronic sinusitis (HP:0011109)	2.71049529
33	Increased cerebral lipofuscin (HP:0011813)	2.64489340
34	Cystic liver disease (HP:0006706)	2.61612290
35	Azoospermia (HP:0000027)	2.59283918
36	Dialeptic seizures (HP:0011146)	2.57900994
37	Subcapsular cataract (HP:0000523)	2.54348242
38	Portal hypertension (HP:0001409)	2.48656648
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.41760526
40	Recurrent sinusitis (HP:0011108)	2.41332816
41	Exocrine pancreatic insufficiency (HP:0001738)	2.41257025
42	Bony spicule pigmentary retinopathy (HP:0007737)	2.38351089
43	Febrile seizures (HP:0002373)	2.35942427
44	Elevated erythrocyte sedimentation rate (HP:0003565)	2.35705204
45	Prostate neoplasm (HP:0100787)	2.33226360
46	Abnormal spermatogenesis (HP:0008669)	2.33176434
47	Abnormality of lateral ventricle (HP:0030047)	2.31305300
48	Abnormality of the hepatic vasculature (HP:0006707)	2.29231287
49	Absence seizures (HP:0002121)	2.19619106
50	Pancreatic fibrosis (HP:0100732)	2.16452117
51	Tubulointerstitial abnormality (HP:0001969)	2.15496090
52	Amyotrophic lateral sclerosis (HP:0007354)	2.14583294
53	Posterior subcapsular cataract (HP:0007787)	2.13881027
54	Nephronophthisis (HP:0000090)	2.13541449
55	Difficulty walking (HP:0002355)	2.12875821
56	True hermaphroditism (HP:0010459)	2.10184479
57	Congenital hepatic fibrosis (HP:0002612)	2.08135021
58	Retinal dysplasia (HP:0007973)	2.01447544
59	Medial flaring of the eyebrow (HP:0010747)	2.01070155
60	Tongue fasciculations (HP:0001308)	1.99876788
61	Broad alveolar ridges (HP:0000187)	1.96923082
62	Facial hemangioma (HP:0000329)	1.96702920
63	Increased corneal curvature (HP:0100692)	1.95033092
64	Keratoconus (HP:0000563)	1.95033092
65	Hepatocellular necrosis (HP:0001404)	1.94630991
66	Thoracic kyphosis (HP:0002942)	1.94135327
67	Recurrent pneumonia (HP:0006532)	1.92662554
68	Abnormality of the renal medulla (HP:0100957)	1.92446079
69	Encephalitis (HP:0002383)	1.91562270
70	Hypoproteinemia (HP:0003075)	1.91405876
71	Recurrent bacterial skin infections (HP:0005406)	1.90715885
72	Poor eye contact (HP:0000817)	1.89030665
73	Hypoalbuminemia (HP:0003073)	1.88932664
74	Abnormal albumin level (HP:0012116)	1.88932664
75	Muscle fibrillation (HP:0010546)	1.88131878
76	Polar cataract (HP:0010696)	1.88103459
77	Cellulitis (HP:0100658)	1.84528564
78	Amelogenesis imperfecta (HP:0000705)	1.84522599
79	Abnormality of male internal genitalia (HP:0000022)	1.83146005
80	Reduced antithrombin III activity (HP:0001976)	1.82862290
81	Focal seizures (HP:0007359)	1.81720726
82	Abnormality of dental color (HP:0011073)	1.79863884
83	Recurrent bronchitis (HP:0002837)	1.79564044
84	Supernumerary spleens (HP:0009799)	1.78104650
85	Prolonged QT interval (HP:0001657)	1.77237560
86	Choroideremia (HP:0001139)	1.76794136
87	Abnormality of the renal cortex (HP:0011035)	1.74784033
88	Abnormality of purine metabolism (HP:0004352)	1.73115241
89	Increased CSF lactate (HP:0002490)	1.72453389
90	Autoimmune thrombocytopenia (HP:0001973)	1.72162158
91	Fair hair (HP:0002286)	1.71748574
92	Gait imbalance (HP:0002141)	1.70880903
93	Progressive microcephaly (HP:0000253)	1.70066420
94	Hypothermia (HP:0002045)	1.69197865
95	Adactyly (HP:0009776)	1.67542123
96	Sclerocornea (HP:0000647)	1.66711035
97	Concave nail (HP:0001598)	1.65218989
98	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.62956900
99	Progressive external ophthalmoplegia (HP:0000590)	1.62447046
100	Visual hallucinations (HP:0002367)	1.60725266

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	9.30256668
2	STK16	5.33937478
3	INSRR	5.03356097
4	GRK1	4.03475076
5	SIK2	2.72952768
6	LATS1	2.41179635
7	NUAK1	2.38477754
8	MAPKAPK3	2.24923456
9	TIE1	2.21890172
10	ITK	2.19466842
11	TEC	2.05674064
12	EIF2AK3	1.93109472
13	KDR	1.81764019
14	BMPR1B	1.78330783
15	MAP2K6	1.65930974
16	ADRBK2	1.54677529
17	DAPK1	1.42155692
18	DAPK2	1.41241952
19	ACVR1B	1.41147347
20	PIK3CG	1.28273285
21	CCNB1	1.27114165
22	PLK4	1.26443162
23	SYK	1.25632044
24	IKBKE	1.25589529
25	FRK	1.25322774
26	TNIK	1.21304222
27	TAF1	1.19465138
28	ZAK	1.03068734
29	CAMKK2	0.97564824
30	RPS6KB2	0.97492955
31	MAP3K9	0.96716430
32	SIK3	0.96070495
33	BTK	0.91138643
34	PASK	0.84586624
35	TYRO3	0.83299003
36	MARK3	0.80337961
37	CASK	0.74664691
38	LYN	0.72563075
39	SIK1	0.71591683
40	MAP3K11	0.71135760
41	TAOK3	0.69686736
42	GRK7	0.68350274
43	PBK	0.66917045
44	PRKCQ	0.64145264
45	NME1	0.62924630
46	MAPK13	0.61503553
47	TGFBR1	0.60243403
48	PAK2	0.59857873
49	LCK	0.57301882
50	KIT	0.56621872
51	RPS6KA6	0.55777910
52	NTRK3	0.55092299
53	PTK2B	0.51312110
54	MATK	0.50481489
55	ADRBK1	0.50287902
56	MARK1	0.49204422
57	PRKCG	0.42068568
58	MAP2K1	0.41690281
59	PAK6	0.41084255
60	FES	0.40435246
61	MAP3K13	0.39040466
62	HIPK2	0.37968363
63	TRPM7	0.36367096
64	PLK2	0.33276595
65	HCK	0.33076511
66	LMTK2	0.32773833
67	RPS6KC1	0.32645607
68	RPS6KL1	0.32645607
69	PHKG2	0.31714817
70	PHKG1	0.31714817
71	DYRK2	0.29983285
72	RPS6KB1	0.26000557
73	CAMK2A	0.25916646
74	RPS6KA2	0.25684405
75	ZAP70	0.25165737
76	MAPKAPK5	0.22631639
77	PDK1	0.21796220
78	PRKCB	0.21385932
79	TNK2	0.20910047
80	CHEK2	0.20679228
81	PRKCA	0.20652395
82	PRKACA	0.19739374
83	IGF1R	0.19076683
84	IRAK1	0.18907646
85	PDPK1	0.18720333
86	MAP3K4	0.18447591
87	MUSK	0.18392175
88	PRKACB	0.17386899
89	PRKCE	0.14934287
90	OBSCN	0.14837117
91	DAPK3	0.14755667
92	CAMKK1	0.14423616
93	FYN	0.14024112
94	PRKD3	0.12459844
95	EPHA2	0.11870880
96	PRKACG	0.11511299
97	TXK	0.10795995
98	INSR	0.10495407
99	NTRK2	0.10328471
100	CAMK2B	0.10283646

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	4.26882446
2	Pancreatic secretion_Homo sapiens_hsa04972	3.99230449
3	Selenocompound metabolism_Homo sapiens_hsa00450	3.90365967
4	Sulfur metabolism_Homo sapiens_hsa00920	3.32935626
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	3.31868457
6	Fat digestion and absorption_Homo sapiens_hsa04975	3.14100280
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.90982081
8	Protein digestion and absorption_Homo sapiens_hsa04974	2.19151343
9	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.95494665
10	Ether lipid metabolism_Homo sapiens_hsa00565	1.85726787
11	Ribosome_Homo sapiens_hsa03010	1.77806418
12	Tryptophan metabolism_Homo sapiens_hsa00380	1.72784630
13	Glycerolipid metabolism_Homo sapiens_hsa00561	1.70687221
14	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.70406437
15	Olfactory transduction_Homo sapiens_hsa04740	1.68975736
16	Primary immunodeficiency_Homo sapiens_hsa05340	1.68604394
17	ABC transporters_Homo sapiens_hsa02010	1.67595660
18	Morphine addiction_Homo sapiens_hsa05032	1.66119839
19	Taste transduction_Homo sapiens_hsa04742	1.64416701
20	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.57813495
21	Nicotine addiction_Homo sapiens_hsa05033	1.54927816
22	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.49736210
23	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.33891344
24	Salivary secretion_Homo sapiens_hsa04970	1.33246810
25	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.29057303
26	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.26578532
27	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.24373623
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.23640950
29	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.23272871
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.10975106
31	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.10742303
32	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.09013832
33	Calcium signaling pathway_Homo sapiens_hsa04020	1.04476058
34	Gastric acid secretion_Homo sapiens_hsa04971	1.03792082
35	Histidine metabolism_Homo sapiens_hsa00340	1.03005399
36	One carbon pool by folate_Homo sapiens_hsa00670	1.02453332
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.02151885
38	Serotonergic synapse_Homo sapiens_hsa04726	1.01517848
39	Asthma_Homo sapiens_hsa05310	1.01203671
40	Glutamatergic synapse_Homo sapiens_hsa04724	0.97613031
41	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.97338501
42	Allograft rejection_Homo sapiens_hsa05330	0.95939096
43	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95747089
44	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.94652310
45	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.93487849
46	Butanoate metabolism_Homo sapiens_hsa00650	0.92614891
47	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.90316746
48	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.88574608
49	Circadian entrainment_Homo sapiens_hsa04713	0.86605940
50	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.85648261
51	Homologous recombination_Homo sapiens_hsa03440	0.85404977
52	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.83710051
53	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.82973276
54	RNA polymerase_Homo sapiens_hsa03020	0.79584106
55	Nitrogen metabolism_Homo sapiens_hsa00910	0.79420949
56	Fatty acid degradation_Homo sapiens_hsa00071	0.78745974
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.78185302
58	Retinol metabolism_Homo sapiens_hsa00830	0.77042046
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75234186
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72839879
61	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.72754198
62	Caffeine metabolism_Homo sapiens_hsa00232	0.71244598
63	Purine metabolism_Homo sapiens_hsa00230	0.68990312
64	Insulin secretion_Homo sapiens_hsa04911	0.68713731
65	GABAergic synapse_Homo sapiens_hsa04727	0.67408665
66	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64923424
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.63914551
68	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.61489048
69	Oxidative phosphorylation_Homo sapiens_hsa00190	0.60939527
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60017475
71	Regulation of autophagy_Homo sapiens_hsa04140	0.57796253
72	Cholinergic synapse_Homo sapiens_hsa04725	0.52198235
73	Parkinsons disease_Homo sapiens_hsa05012	0.50905689
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.50072505
75	Cocaine addiction_Homo sapiens_hsa05030	0.49309327
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.48696771
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.46849832
78	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.46809414
79	Steroid biosynthesis_Homo sapiens_hsa00100	0.46628685
80	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.44946362
81	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.43457071
82	Platelet activation_Homo sapiens_hsa04611	0.42609062
83	Bile secretion_Homo sapiens_hsa04976	0.42353485
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.41812256
85	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.39936026
86	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.39638320
87	Metabolic pathways_Homo sapiens_hsa01100	0.38586289
88	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.38246933
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36980113
90	Peroxisome_Homo sapiens_hsa04146	0.36516758
91	Amphetamine addiction_Homo sapiens_hsa05031	0.35255523
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35105242
93	Huntingtons disease_Homo sapiens_hsa05016	0.34888246
94	Antigen processing and presentation_Homo sapiens_hsa04612	0.33880455
95	African trypanosomiasis_Homo sapiens_hsa05143	0.32928657
96	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.32722853
97	Renin secretion_Homo sapiens_hsa04924	0.31601532
98	Ras signaling pathway_Homo sapiens_hsa04014	0.30719188
99	Rheumatoid arthritis_Homo sapiens_hsa05323	0.29999670
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.27745162

REXO1L2P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »