REXO1L6P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to vitamin A (GO:0033189)8.71620016
2epithelial structure maintenance (GO:0010669)8.42381952
3cellular response to epidermal growth factor stimulus (GO:0071364)6.90818797
4nephron tubule morphogenesis (GO:0072078)6.54862952
5nephron epithelium morphogenesis (GO:0072088)6.54862952
6O-glycan processing (GO:0016266)5.88448005
7phosphate ion homeostasis (GO:0055062)5.66306259
8trivalent inorganic anion homeostasis (GO:0072506)5.66306259
9phosphate ion transport (GO:0006817)5.35872577
10response to epidermal growth factor (GO:0070849)5.18209472
11phosphate ion transmembrane transport (GO:0035435)5.08118313
12Arp2/3 complex-mediated actin nucleation (GO:0034314)4.93906050
13regulation of ARF GTPase activity (GO:0032312)4.77581364
14renal tubule morphogenesis (GO:0061333)4.63229360
15cellular anion homeostasis (GO:0030002)4.60499881
16actin nucleation (GO:0045010)4.56217986
17cell wall macromolecule metabolic process (GO:0044036)4.51798861
18C21-steroid hormone biosynthetic process (GO:0006700)4.40147426
19rhodopsin mediated signaling pathway (GO:0016056)4.32656806
20cellular response to zinc ion (GO:0071294)4.27492350
21cilium or flagellum-dependent cell motility (GO:0001539)4.25429846
22membrane depolarization during action potential (GO:0086010)4.23842427
23neuronal action potential (GO:0019228)4.01274847
24protein O-linked glycosylation (GO:0006493)3.98875808
25glucocorticoid biosynthetic process (GO:0006704)3.96606808
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96295045
27tachykinin receptor signaling pathway (GO:0007217)3.94583601
28negative regulation of digestive system process (GO:0060457)3.91133861
29membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.90083434
30establishment of protein localization to Golgi (GO:0072600)3.87192160
31regulation of rhodopsin mediated signaling pathway (GO:0022400)3.72775508
32cellular response to glucocorticoid stimulus (GO:0071385)3.71688425
33renal absorption (GO:0070293)3.67387865
34protein targeting to Golgi (GO:0000042)3.67387273
35positive regulation of chemokine secretion (GO:0090197)3.64050274
36cellular response to corticosteroid stimulus (GO:0071384)3.57847164
37regulation of RIG-I signaling pathway (GO:0039535)3.52091397
38multicellular organism reproduction (GO:0032504)3.48947125
39membrane repolarization during action potential (GO:0086011)3.37631267
40positive regulation of uterine smooth muscle contraction (GO:0070474)3.36306544
41regulation of acrosome reaction (GO:0060046)3.35196060
42histone H2A acetylation (GO:0043968)3.30629830
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29508301
44NIK/NF-kappaB signaling (GO:0038061)3.29166658
45retrograde transport, vesicle recycling within Golgi (GO:0000301)3.27001423
46digestive system process (GO:0022600)3.26697497
47L-fucose catabolic process (GO:0042355)3.22495262
48fucose catabolic process (GO:0019317)3.22495262
49L-fucose metabolic process (GO:0042354)3.22495262
50transmission of nerve impulse (GO:0019226)3.20572119
51auditory receptor cell stereocilium organization (GO:0060088)3.18606224
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14937142
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06049972
54calcium ion import (GO:0070509)3.05414821
55regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.03031592
56regulation of chemokine secretion (GO:0090196)3.02741740
57production of molecular mediator involved in inflammatory response (GO:0002532)2.99096560
58positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.97781482
59positive regulation of natural killer cell mediated immunity (GO:0002717)2.93797258
60glucosamine-containing compound catabolic process (GO:1901072)2.92446450
61protein localization to Golgi apparatus (GO:0034067)2.90430036
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.90322351
63negative regulation of cell killing (GO:0031342)2.90322351
64positive regulation of endothelial cell differentiation (GO:0045603)2.85441219
65GDP-mannose metabolic process (GO:0019673)2.85322100
66receptor guanylyl cyclase signaling pathway (GO:0007168)2.83636883
67regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81785668
68regulation of natural killer cell mediated immunity (GO:0002715)2.81785668
69positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.81290254
70positive regulation of CREB transcription factor activity (GO:0032793)2.81202448
71regulation of hippo signaling (GO:0035330)2.75184725
72striated muscle atrophy (GO:0014891)2.74892905
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74411849
74actin filament capping (GO:0051693)2.72501685
75regulation of ruffle assembly (GO:1900027)2.72037799
76actin filament depolymerization (GO:0030042)2.69502703
77sperm capacitation (GO:0048240)2.65110610
78vocalization behavior (GO:0071625)2.65065184
79dendritic cell chemotaxis (GO:0002407)2.63507436
80sequestering of actin monomers (GO:0042989)2.63321657
81phospholipid scrambling (GO:0017121)2.60233624
82single fertilization (GO:0007338)2.59385468
83regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.59269110
84photoreceptor cell development (GO:0042461)2.57053103
85sperm motility (GO:0030317)2.56631198
86regulation of uterine smooth muscle contraction (GO:0070472)2.56337321
87creatine metabolic process (GO:0006600)2.56103124
88behavioral response to nicotine (GO:0035095)2.55894851
89positive regulation of digestive system process (GO:0060456)2.55721886
90potassium ion export (GO:0071435)2.55065411
91inositol metabolic process (GO:0006020)2.48961325
92photoreceptor cell maintenance (GO:0045494)2.47001550
93negative regulation of multicellular organism growth (GO:0040015)2.46310215
94skeletal muscle adaptation (GO:0043501)2.45632851
95mating behavior (GO:0007617)2.45342791
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.44673558
97positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.44393127
98cytolysis (GO:0019835)2.43655014
99regulation of G0 to G1 transition (GO:0070316)12.8301954
100maintenance of gastrointestinal epithelium (GO:0030277)11.2521550

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.22482937
2DROSHA_22980978_ChIP-Seq_HELA_Human4.48029449
3* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.71735797
4GATA1_22025678_ChIP-Seq_K562_Human3.08577715
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.36376848
6WDR5_24793694_ChIP-Seq_LNCAP_Human2.25834087
7ZNF274_21170338_ChIP-Seq_K562_Hela2.23147692
8VDR_22108803_ChIP-Seq_LS180_Human2.17326672
9GBX2_23144817_ChIP-Seq_PC3_Human2.13128038
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04203587
11BCAT_22108803_ChIP-Seq_LS180_Human1.95107928
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94587409
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90311294
14BCL6_27268052_Chip-Seq_Bcells_Human1.87526669
15E2F1_20622854_ChIP-Seq_HELA_Human1.85011357
16ER_23166858_ChIP-Seq_MCF-7_Human1.83168820
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.81083776
18IRF8_22096565_ChIP-ChIP_GC-B_Human1.80520838
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77841246
20CTCF_27219007_Chip-Seq_Bcells_Human1.75747978
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62602623
22OCT4_20526341_ChIP-Seq_ESCs_Human1.61889110
23SMC4_20622854_ChIP-Seq_HELA_Human1.60062516
24BCOR_27268052_Chip-Seq_Bcells_Human1.53129508
25RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52981359
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51733532
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51032785
28TAF2_19829295_ChIP-Seq_ESCs_Human1.48291903
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.47540506
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47356019
31ERA_21632823_ChIP-Seq_H3396_Human1.46572521
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46075384
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44710845
34TDRD3_21172665_ChIP-Seq_MCF-7_Human1.43293189
35NFYA_21822215_ChIP-Seq_K562_Human1.42521075
36RUNX_20019798_ChIP-Seq_JUKART_Human1.40288951
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39453169
38CTCF_20526341_ChIP-Seq_ESCs_Human1.35430173
39PRDM14_20953172_ChIP-Seq_ESCs_Human1.35309284
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34291952
41RXR_22108803_ChIP-Seq_LS180_Human1.33805186
42P53_21459846_ChIP-Seq_SAOS-2_Human1.32689017
43P68_20966046_ChIP-Seq_HELA_Human1.32255465
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31122457
45ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30128562
46TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29426826
47RAC3_21632823_ChIP-Seq_H3396_Human1.29298475
48NCOR_22424771_ChIP-Seq_293T_Human1.26829193
49CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26289276
50PHF8_20622854_ChIP-Seq_HELA_Human1.23825072
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23758005
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22473879
53AR_21572438_ChIP-Seq_LNCaP_Human1.20328031
54GATA3_27048872_Chip-Seq_THYMUS_Human1.18570219
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18222766
56NANOG_20526341_ChIP-Seq_ESCs_Human1.17583587
57GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17493077
58AR_20517297_ChIP-Seq_VCAP_Human1.15600376
59EED_16625203_ChIP-ChIP_MESCs_Mouse1.15533221
60NFYB_21822215_ChIP-Seq_K562_Human1.15083380
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14527345
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.14280379
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13618401
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13551217
65CDX2_22108803_ChIP-Seq_LS180_Human1.13439070
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11951376
67RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11951376
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11540654
69SA1_27219007_Chip-Seq_Bcells_Human1.11176210
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11093604
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.10142291
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09605147
73OCT4_19829295_ChIP-Seq_ESCs_Human1.08711033
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08372873
75PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08334552
76SPI1_20517297_ChIP-Seq_HL60_Human1.07678135
77P300_27268052_Chip-Seq_Bcells_Human1.06478218
78YY1_22570637_ChIP-Seq_MALME-3M_Human1.05787904
79HNFA_21074721_ChIP-Seq_CACO-2_Human1.05311074
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04337708
81CBP_20019798_ChIP-Seq_JUKART_Human1.04337708
82TP53_22573176_ChIP-Seq_HFKS_Human1.04322988
83ERG_20517297_ChIP-Seq_VCAP_Human1.04230209
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03251952
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02976260
86KLF4_19829295_ChIP-Seq_ESCs_Human1.02451016
87MYC_19829295_ChIP-Seq_ESCs_Human1.02300021
88SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02215046
89OCT1_27270436_Chip-Seq_PROSTATE_Human1.02008014
90E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00965827
91JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00345678
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.98520078
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98448482
94CBP_21632823_ChIP-Seq_H3396_Human0.97995269
95TBL1_22424771_ChIP-Seq_293T_Human0.97728487
96STAT3_23295773_ChIP-Seq_U87_Human0.97453806
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.96422847
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96422847
99TCF4_22108803_ChIP-Seq_LS180_Human0.96119795
100RUNX2_22187159_ChIP-Seq_PCA_Human0.93879597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.48417180
2MP0003878_abnormal_ear_physiology5.48417180
3MP0004043_abnormal_pH_regulation4.73080806
4MP0000465_gastrointestinal_hemorrhage3.68319819
5MP0000579_abnormal_nail_morphology3.59948554
6MP0003866_abnormal_defecation3.19742737
7MP0003879_abnormal_hair_cell3.15976146
8MP0001485_abnormal_pinna_reflex2.97697362
9MP0001765_abnormal_ion_homeostasis2.48166088
10MP0000566_synostosis2.46427789
11MP0002822_catalepsy2.46195547
12MP0003252_abnormal_bile_duct2.30450494
13MP0001666_abnormal_nutrient_absorption2.28112963
14MP0004019_abnormal_vitamin_homeostasis2.26333388
15MP0005671_abnormal_response_to2.22400336
16MP0002138_abnormal_hepatobiliary_system2.16938658
17MP0003646_muscle_fatigue1.99399532
18MP0005551_abnormal_eye_electrophysiolog1.93522505
19MP0000383_abnormal_hair_follicle1.82266830
20MP0003045_fibrosis1.77657931
21MP0001664_abnormal_digestion1.73582615
22MP0005645_abnormal_hypothalamus_physiol1.69021453
23MP0003283_abnormal_digestive_organ1.67598830
24MP0001661_extended_life_span1.60625444
25MP0000427_abnormal_hair_cycle1.59527139
26MP0008004_abnormal_stomach_pH1.58766501
27MP0005083_abnormal_biliary_tract1.56291730
28MP0003195_calcinosis1.55249166
29MP0004742_abnormal_vestibular_system1.54078372
30MP0002928_abnormal_bile_duct1.53982775
31MP0003136_yellow_coat_color1.49093608
32MP0005275_abnormal_skin_tensile1.40318799
33MP0001663_abnormal_digestive_system1.36352767
34MP0010155_abnormal_intestine_physiology1.27985132
35MP0010386_abnormal_urinary_bladder1.27755836
36MP0000538_abnormal_urinary_bladder1.25845892
37MP0001963_abnormal_hearing_physiology1.24963135
38MP0008995_early_reproductive_senescence1.24933894
39MP0009785_altered_susceptibility_to1.24484617
40MP0001501_abnormal_sleep_pattern1.23771707
41MP0000026_abnormal_inner_ear1.21363714
42MP0001968_abnormal_touch/_nociception1.20997364
43MP0003705_abnormal_hypodermis_morpholog1.20481774
44MP0000751_myopathy1.19205365
45MP0009333_abnormal_splenocyte_physiolog1.17442170
46MP0005257_abnormal_intraocular_pressure1.17134392
47MP0001764_abnormal_homeostasis1.14074655
48MP0001243_abnormal_dermal_layer1.11514418
49MP0001835_abnormal_antigen_presentation1.11006535
50MP0005381_digestive/alimentary_phenotyp1.09679210
51MP0002733_abnormal_thermal_nociception1.09678240
52MP0002736_abnormal_nociception_after1.08458401
53MP0010678_abnormal_skin_adnexa1.06118588
54MP0002098_abnormal_vibrissa_morphology1.04317954
55MP0003763_abnormal_thymus_physiology1.03737848
56MP0002735_abnormal_chemical_nociception1.02686852
57MP0002166_altered_tumor_susceptibility1.01711900
58MP0003786_premature_aging0.99428287
59MP0004145_abnormal_muscle_electrophysio0.98428288
60MP0003950_abnormal_plasma_membrane0.98264009
61MP0000749_muscle_degeneration0.98208869
62MP0000678_abnormal_parathyroid_gland0.94671131
63MP0005636_abnormal_mineral_homeostasis0.93671939
64MP0005410_abnormal_fertilization0.90676129
65MP0000230_abnormal_systemic_arterial0.89903367
66MP0000647_abnormal_sebaceous_gland0.89806032
67MP0002272_abnormal_nervous_system0.83483364
68MP0002136_abnormal_kidney_physiology0.82549717
69MP0005310_abnormal_salivary_gland0.82349768
70MP0002638_abnormal_pupillary_reflex0.81340519
71MP0002229_neurodegeneration0.80532783
72MP0003137_abnormal_impulse_conducting0.78637677
73MP0001970_abnormal_pain_threshold0.75758076
74MP0005253_abnormal_eye_physiology0.75756975
75MP0005025_abnormal_response_to0.75373675
76MP0003698_abnormal_male_reproductive0.74884519
77MP0004133_heterotaxia0.74263912
78MP0002160_abnormal_reproductive_system0.74024791
79MP0009643_abnormal_urine_homeostasis0.73127751
80MP0001542_abnormal_bone_strength0.72891337
81MP0002067_abnormal_sensory_capabilities0.72732055
82MP0004147_increased_porphyrin_level0.70202750
83MP0001958_emphysema0.67462220
84MP0002249_abnormal_larynx_morphology0.66587377
85MP0003091_abnormal_cell_migration0.66217450
86MP0002693_abnormal_pancreas_physiology0.65752935
87MP0000371_diluted_coat_color0.64640291
88MP0002060_abnormal_skin_morphology0.62330639
89MP0000372_irregular_coat_pigmentation0.62037530
90MP0001502_abnormal_circadian_rhythm0.61931842
91MP0000470_abnormal_stomach_morphology0.61394599
92MP0004142_abnormal_muscle_tone0.61179263
93MP0002653_abnormal_ependyma_morphology0.60411057
94MP0002006_tumorigenesis0.57920168
95MP0002752_abnormal_somatic_nervous0.56113065
96MP0002095_abnormal_skin_pigmentation0.55667187
97MP0002572_abnormal_emotion/affect_behav0.55284220
98MP0001800_abnormal_humoral_immune0.54979979
99MP0001929_abnormal_gametogenesis0.54954157
100MP0002909_abnormal_adrenal_gland0.54500287

Predicted human phenotypes

RankGene SetZ-score
1Congenital sensorineural hearing impairment (HP:0008527)5.59829777
2Palpebral edema (HP:0100540)5.53565313
3Thin bony cortex (HP:0002753)5.41158134
4Hyperkalemia (HP:0002153)5.29954765
5Pili torti (HP:0003777)5.29236707
6Enlarged epiphyses (HP:0010580)4.99792761
7Bilateral sensorineural hearing impairment (HP:0008619)4.94560009
8Attenuation of retinal blood vessels (HP:0007843)4.71875494
9Abnormality of dentin (HP:0010299)4.52712831
10Delayed epiphyseal ossification (HP:0002663)4.46464262
11Abnormality of chloride homeostasis (HP:0011422)3.98304207
12Pendular nystagmus (HP:0012043)3.92877156
13Mask-like facies (HP:0000298)3.91514440
14Generalized aminoaciduria (HP:0002909)3.89827098
15Severe visual impairment (HP:0001141)3.83266943
16Abnormality of DNA repair (HP:0003254)3.74668006
17Widely patent fontanelles and sutures (HP:0004492)3.73841459
18Cystic liver disease (HP:0006706)3.67783547
19Abnormality of the costochondral junction (HP:0000919)3.66856785
20Hypophosphatemic rickets (HP:0004912)3.53335407
21Abnormality of the renal collecting system (HP:0004742)3.52472607
22Tibial bowing (HP:0002982)3.46975610
23Duplicated collecting system (HP:0000081)3.43962606
24Urethral obstruction (HP:0000796)3.28437276
25Increased corneal curvature (HP:0100692)3.22645637
26Keratoconus (HP:0000563)3.22645637
27Abnormal hair laboratory examination (HP:0003328)3.18324667
28Bony spicule pigmentary retinopathy (HP:0007737)3.05087263
29Malnutrition (HP:0004395)2.95858292
30Hyperactive renin-angiotensin system (HP:0000841)2.79528261
31Patent foramen ovale (HP:0001655)2.78256101
32Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77161883
33Periorbital edema (HP:0100539)2.75954614
34Nonimmune hydrops fetalis (HP:0001790)2.73431403
35Flat occiput (HP:0005469)2.71230063
36Chromsome breakage (HP:0040012)2.65534027
37Pancreatic cysts (HP:0001737)2.61941646
38Facial edema (HP:0000282)2.61758518
39Decreased circulating renin level (HP:0003351)2.58119815
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.51840443
41True hermaphroditism (HP:0010459)2.50699026
42Abolished electroretinogram (ERG) (HP:0000550)2.48344931
43Ureteral duplication (HP:0000073)2.47258510
44Abnormality of potassium homeostasis (HP:0011042)2.42784020
45Abnormality of the dental pulp (HP:0006479)2.40371274
46Broad face (HP:0000283)2.36932765
47Distal lower limb amyotrophy (HP:0008944)2.35264258
48Abnormality of pyrimidine metabolism (HP:0004353)2.35071217
49Distal upper limb amyotrophy (HP:0007149)2.33639809
50Upper limb amyotrophy (HP:0009129)2.33639809
51Rickets (HP:0002748)2.31141456
52Hemorrhage of the eye (HP:0011885)2.28716247
53Abnormal trabecular bone morphology (HP:0100671)2.28425962
54Abnormality of renin-angiotensin system (HP:0000847)2.27886596
55Mildly elevated creatine phosphokinase (HP:0008180)2.24565762
56Duplication of thumb phalanx (HP:0009942)2.24337558
57Morphological abnormality of the middle ear (HP:0008609)2.23850764
58Metaphyseal irregularity (HP:0003025)2.22371589
59Congenital stationary night blindness (HP:0007642)2.21849633
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19003345
61Abnormality of dental color (HP:0011073)2.17167577
62Pancreatic fibrosis (HP:0100732)2.13816303
63Abnormality of the carotid arteries (HP:0005344)2.05627390
64Clubbing of toes (HP:0100760)2.04884465
65Short 1st metacarpal (HP:0010034)2.04397824
66Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.04397824
67Bronchomalacia (HP:0002780)2.02624524
68Wide cranial sutures (HP:0010537)2.01643677
69Abnormality of the 1st metacarpal (HP:0010009)2.01435790
70Decreased central vision (HP:0007663)2.00530066
71Congenital, generalized hypertrichosis (HP:0004540)2.00000431
72Abnormality of the preputium (HP:0100587)1.99816499
73Ectopic kidney (HP:0000086)1.99758587
74Femoral bowing (HP:0002980)1.99038914
75Meckel diverticulum (HP:0002245)1.95895816
76Abnormality of the ileum (HP:0001549)1.95138562
77Reticulocytopenia (HP:0001896)1.89788580
78Abnormal rod and cone electroretinograms (HP:0008323)1.89050385
79Clumsiness (HP:0002312)1.86007569
80Male infertility (HP:0003251)1.85217067
81Abnormal biliary tract physiology (HP:0012439)1.84119934
82Bile duct proliferation (HP:0001408)1.84119934
83Pigmentary retinal degeneration (HP:0001146)1.84012564
84Partial duplication of thumb phalanx (HP:0009944)1.83500935
85Broad metatarsal (HP:0001783)1.82632078
86Macular degeneration (HP:0000608)1.74274822
87Abnormality of the aortic arch (HP:0012303)1.74102177
88Abnormal number of incisors (HP:0011064)1.74015989
89Spinal muscular atrophy (HP:0007269)1.72461230
90Short phalanx of the thumb (HP:0009660)1.71730422
91Progressive cerebellar ataxia (HP:0002073)1.71434599
92Abnormality of cochlea (HP:0000375)1.70314377
93Poikiloderma (HP:0001029)1.70244244
94Stridor (HP:0010307)1.69753055
95Neonatal short-limb short stature (HP:0008921)1.68409761
96Entropion (HP:0000621)1.67995419
97Abnormal ciliary motility (HP:0012262)1.66891602
98Renal salt wasting (HP:0000127)1.66189437
99Difficulty walking (HP:0002355)1.64965315
100Elevated alkaline phosphatase (HP:0003155)1.64779407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK47.67225130
2MST1R6.61756518
3NME14.68418568
4TESK23.39042807
5KDR3.01095787
6TAOK32.79870310
7WNK12.54522013
8MAP4K12.44914281
9INSRR2.35044100
10FRK2.17495685
11MET2.13635858
12TESK11.97787838
13MUSK1.82097610
14ADRBK21.71089158
15IKBKE1.55071030
16MAP2K61.51490199
17MAPK151.48848094
18PASK1.34199721
19TXK1.30536154
20CDK121.24304333
21MAP3K121.22132022
22NEK21.16229132
23MAP4K21.15610253
24STK391.10758856
25LIMK11.10653207
26TNK21.07682695
27MAP3K111.06314728
28BLK1.03320905
29CSF1R1.03123856
30LMTK21.02200107
31CAMK1D0.96299647
32OXSR10.94014623
33ADRBK10.91844976
34DDR20.90858234
35ZAK0.89962800
36GRK70.88824329
37ZAP700.87917835
38TYRO30.86007635
39PIK3CG0.84260501
40GRK10.78557183
41CAMKK10.74884067
42FES0.74457564
43SIK20.73420476
44LCK0.68067127
45TBK10.66473041
46MAP3K130.65612792
47PRKCH0.64878396
48MARK30.64792991
49PDK10.63712546
50MAPKAPK30.62642403
51CAMKK20.61646878
52ACVR1B0.59663698
53TIE10.59597737
54ERBB20.59113199
55MAP3K70.58608814
56PRKCQ0.56882124
57PRKG20.54556549
58BTK0.49392629
59BMPR1B0.46867995
60SIK10.46437454
61CAMK1G0.45482488
62SYK0.45144058
63LYN0.43469748
64BCKDK0.41114437
65ITK0.38412856
66DAPK10.37260692
67TRIB30.37040881
68PTK2B0.36547493
69STK160.35123412
70CDK80.31633628
71TEC0.31225926
72CDK190.30993276
73CHEK20.29187395
74PDGFRB0.28666848
75SGK10.28525221
76RPS6KA60.27492860
77AURKA0.26653137
78TLK10.25401715
79VRK20.25319408
80PRKACA0.23813437
81IKBKB0.23436777
82IGF1R0.23348989
83MAP2K20.22307300
84PRKAA20.19933370
85PRKCI0.19675949
86FYN0.18895229
87NTRK20.18786111
88MAPK30.17859412
89PRKCG0.17644759
90TAOK20.17588650
91MAP3K50.16747752
92PIK3CA0.16472706
93ATR0.15727669
94PHKG10.15367422
95PHKG20.15367422
96PRKCA0.15265866
97DYRK20.14875452
98TAF10.14788333
99INSR0.14224292
100CAMK2B0.14073130

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.48840766
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.51526765
3Salivary secretion_Homo sapiens_hsa049702.72045282
4Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.56658895
5Primary immunodeficiency_Homo sapiens_hsa053402.51528959
6Taste transduction_Homo sapiens_hsa047422.23818466
7ABC transporters_Homo sapiens_hsa020102.23663312
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.13108567
9Linoleic acid metabolism_Homo sapiens_hsa005912.11548051
10Olfactory transduction_Homo sapiens_hsa047402.09387195
11Nitrogen metabolism_Homo sapiens_hsa009101.90442293
12Fanconi anemia pathway_Homo sapiens_hsa034601.89268378
13Nicotine addiction_Homo sapiens_hsa050331.87914640
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81927478
15Protein digestion and absorption_Homo sapiens_hsa049741.76305568
16Oocyte meiosis_Homo sapiens_hsa041141.67471786
17Mineral absorption_Homo sapiens_hsa049781.62018483
18Ovarian steroidogenesis_Homo sapiens_hsa049131.56254490
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55406588
20Fatty acid biosynthesis_Homo sapiens_hsa000611.52671896
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.51617665
22Circadian entrainment_Homo sapiens_hsa047131.51204598
23Retinol metabolism_Homo sapiens_hsa008301.49407903
24Cocaine addiction_Homo sapiens_hsa050301.36054069
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33754697
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31521939
27Homologous recombination_Homo sapiens_hsa034401.29872670
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29580410
29Morphine addiction_Homo sapiens_hsa050321.26173477
30Chemical carcinogenesis_Homo sapiens_hsa052041.25415438
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25157543
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.22437522
33Graft-versus-host disease_Homo sapiens_hsa053321.18997694
34Antigen processing and presentation_Homo sapiens_hsa046121.18455267
35Bile secretion_Homo sapiens_hsa049761.18408612
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17589225
37Calcium signaling pathway_Homo sapiens_hsa040201.15978113
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10518861
39Vitamin digestion and absorption_Homo sapiens_hsa049771.09791507
40Amphetamine addiction_Homo sapiens_hsa050311.07662275
41ECM-receptor interaction_Homo sapiens_hsa045121.04905491
42Cardiac muscle contraction_Homo sapiens_hsa042601.02200468
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02176769
44T cell receptor signaling pathway_Homo sapiens_hsa046601.01206766
45Insulin secretion_Homo sapiens_hsa049110.99583433
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98301069
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.97096563
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.95518038
49Glutamatergic synapse_Homo sapiens_hsa047240.93078459
50Renin-angiotensin system_Homo sapiens_hsa046140.92982556
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92472660
52Pancreatic secretion_Homo sapiens_hsa049720.90808929
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.89861019
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89174246
55Fructose and mannose metabolism_Homo sapiens_hsa000510.89037616
56Cholinergic synapse_Homo sapiens_hsa047250.86040623
57Gastric acid secretion_Homo sapiens_hsa049710.85760473
58Serotonergic synapse_Homo sapiens_hsa047260.83062422
59Hematopoietic cell lineage_Homo sapiens_hsa046400.82317660
60GABAergic synapse_Homo sapiens_hsa047270.79620852
61Caffeine metabolism_Homo sapiens_hsa002320.78756810
62One carbon pool by folate_Homo sapiens_hsa006700.78569012
63cAMP signaling pathway_Homo sapiens_hsa040240.78124255
64Renin secretion_Homo sapiens_hsa049240.76504620
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73933516
66Sulfur metabolism_Homo sapiens_hsa009200.71171901
67Amoebiasis_Homo sapiens_hsa051460.70844525
68Autoimmune thyroid disease_Homo sapiens_hsa053200.69688299
69Arachidonic acid metabolism_Homo sapiens_hsa005900.68817103
70Ether lipid metabolism_Homo sapiens_hsa005650.68816923
71Vibrio cholerae infection_Homo sapiens_hsa051100.67927582
72Starch and sucrose metabolism_Homo sapiens_hsa005000.65998232
73Glycerolipid metabolism_Homo sapiens_hsa005610.65155003
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63517734
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63427088
76Allograft rejection_Homo sapiens_hsa053300.61396823
77Thyroid hormone synthesis_Homo sapiens_hsa049180.60692528
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59011731
79Malaria_Homo sapiens_hsa051440.55750888
80Butanoate metabolism_Homo sapiens_hsa006500.55278356
81Systemic lupus erythematosus_Homo sapiens_hsa053220.54683923
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52805976
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50699064
84Alzheimers disease_Homo sapiens_hsa050100.49811176
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.47440094
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46894049
87Purine metabolism_Homo sapiens_hsa002300.45589493
88Arginine biosynthesis_Homo sapiens_hsa002200.44509824
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44205837
90Dilated cardiomyopathy_Homo sapiens_hsa054140.42772374
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41983211
92Alcoholism_Homo sapiens_hsa050340.41710028
93Type I diabetes mellitus_Homo sapiens_hsa049400.41660109
94Selenocompound metabolism_Homo sapiens_hsa004500.41521569
95Intestinal immune network for IgA production_Homo sapiens_hsa046720.41079698
96Type II diabetes mellitus_Homo sapiens_hsa049300.40700826
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39612632
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39292507
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.39179476
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38797155

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