REXO2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.23208818
2DNA deamination (GO:0045006)4.77600768
3establishment of integrated proviral latency (GO:0075713)4.41878837
4ribosome assembly (GO:0042255)4.39556818
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.97527158
6ribosomal small subunit assembly (GO:0000028)3.83329891
7chaperone-mediated protein transport (GO:0072321)3.77585770
8establishment of viral latency (GO:0019043)3.76974022
9proteasome assembly (GO:0043248)3.62159164
10cullin deneddylation (GO:0010388)3.61247492
11protein deneddylation (GO:0000338)3.58581397
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.57281290
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.55505474
14antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.51055630
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49524041
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.45246169
17regulation of mitochondrial translation (GO:0070129)3.39885838
18cotranslational protein targeting to membrane (GO:0006613)3.39506590
19protein targeting to ER (GO:0045047)3.38286060
20mitotic metaphase plate congression (GO:0007080)3.37612698
21rRNA modification (GO:0000154)3.37124811
22heme biosynthetic process (GO:0006783)3.36019609
23transcription elongation from RNA polymerase III promoter (GO:0006385)3.34253807
24termination of RNA polymerase III transcription (GO:0006386)3.34253807
25heme metabolic process (GO:0042168)3.32658447
26regulation of ubiquitin-protein transferase activity (GO:0051438)3.32235883
27CENP-A containing nucleosome assembly (GO:0034080)3.32054625
28protein localization to endoplasmic reticulum (GO:0070972)3.31540360
29aldehyde catabolic process (GO:0046185)3.23852445
30establishment of protein localization to endoplasmic reticulum (GO:0072599)3.19693440
31regulation of ligase activity (GO:0051340)3.19640322
32ATP synthesis coupled proton transport (GO:0015986)3.14867818
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.14867818
34ventricular cardiac muscle cell development (GO:0055015)3.14843977
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.13476852
36chromatin remodeling at centromere (GO:0031055)3.13198473
37regulation of cellular amino acid metabolic process (GO:0006521)3.12544463
38protein neddylation (GO:0045116)3.11078517
39antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.08495916
40antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.06554467
41antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.06554467
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.04175501
43deoxyribose phosphate biosynthetic process (GO:0046385)3.01881822
442-deoxyribonucleotide biosynthetic process (GO:0009265)3.01881822
45nucleotide-sugar biosynthetic process (GO:0009226)2.98459640
46negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.97518728
47protein retention in ER lumen (GO:0006621)2.95447616
48L-methionine salvage (GO:0071267)2.94390878
49L-methionine biosynthetic process (GO:0071265)2.94390878
50amino acid salvage (GO:0043102)2.94390878
51regulation of metalloenzyme activity (GO:0048552)2.94032048
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93486802
53metaphase plate congression (GO:0051310)2.93058853
54formation of translation preinitiation complex (GO:0001731)2.90978550
55viral transcription (GO:0019083)2.88311367
56purine-containing compound salvage (GO:0043101)2.87693613
57intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.87336018
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.87336018
59tRNA aminoacylation for protein translation (GO:0006418)2.86754900
60translational termination (GO:0006415)2.86498578
61negative regulation of protein ubiquitination (GO:0031397)2.86253613
62establishment of protein localization to mitochondrion (GO:0072655)2.85641180
63maturation of SSU-rRNA (GO:0030490)2.83837534
64respiratory electron transport chain (GO:0022904)2.82483567
65protein localization to mitochondrion (GO:0070585)2.82474592
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82177990
67ribosomal small subunit biogenesis (GO:0042274)2.82147709
68rRNA methylation (GO:0031167)2.81808657
69signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81223901
70signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81223901
71signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81223901
72G1/S transition of mitotic cell cycle (GO:0000082)2.80424732
73cell cycle G1/S phase transition (GO:0044843)2.80424732
74translation (GO:0006412)2.80132413
75Golgi transport vesicle coating (GO:0048200)2.80028914
76COPI coating of Golgi vesicle (GO:0048205)2.80028914
77tRNA aminoacylation (GO:0043039)2.78981902
78amino acid activation (GO:0043038)2.78981902
79respiratory chain complex IV assembly (GO:0008535)2.77934193
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77097419
81negative regulation of ligase activity (GO:0051352)2.77097419
82electron transport chain (GO:0022900)2.75587954
83type B pancreatic cell proliferation (GO:0044342)2.74982354
84regulation of protein heterodimerization activity (GO:0043497)2.74383462
85regulation of mitotic spindle organization (GO:0060236)2.74381408
86telomere maintenance via semi-conservative replication (GO:0032201)2.72687529
87DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.70053518
88extracellular fibril organization (GO:0043206)2.69890207
89negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.69865452
90protein complex biogenesis (GO:0070271)2.69748130
91signal transduction involved in DNA damage checkpoint (GO:0072422)2.69097867
92signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69097867
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68830885
94pteridine-containing compound biosynthetic process (GO:0042559)2.67338137
957-methylguanosine mRNA capping (GO:0006370)2.67304260
96transcription-coupled nucleotide-excision repair (GO:0006283)2.67013116
97histone exchange (GO:0043486)2.66973154
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66949278
99cofactor catabolic process (GO:0051187)2.66255140
100mitochondrial respiratory chain complex assembly (GO:0033108)2.66080936
101deoxyribonucleotide biosynthetic process (GO:0009263)2.65212729
102protein maturation by protein folding (GO:0022417)2.64735173
103L-serine metabolic process (GO:0006563)2.64286644
104positive regulation of actin filament depolymerization (GO:0030836)2.64081281
105peptidyl-histidine modification (GO:0018202)2.63307361
106antigen processing and presentation of endogenous antigen (GO:0019883)2.63195887
107maturation of 5.8S rRNA (GO:0000460)2.63053494
108negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.62668540
109translational elongation (GO:0006414)2.62173628
110regulation of spindle organization (GO:0090224)2.61407004
111signal transduction involved in cell cycle checkpoint (GO:0072395)2.60918376
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.60791922
113neutrophil activation involved in immune response (GO:0002283)2.59857144
1147-methylguanosine RNA capping (GO:0009452)2.58730335
115RNA capping (GO:0036260)2.58730335
116proline biosynthetic process (GO:0006561)2.57085359
117protoporphyrinogen IX biosynthetic process (GO:0006782)2.56732723
118IMP biosynthetic process (GO:0006188)2.56540182
119response to interferon-beta (GO:0035456)2.56248931
120termination of RNA polymerase I transcription (GO:0006363)2.53508564
121GDP-mannose metabolic process (GO:0019673)2.51263975
122regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51004411
123purine nucleotide salvage (GO:0032261)2.50990464
124Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50793252
125cellular response to interferon-beta (GO:0035458)2.49204322
126folic acid-containing compound biosynthetic process (GO:0009396)2.47685683
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45191593
128porphyrin-containing compound metabolic process (GO:0006778)2.42566615
129translational initiation (GO:0006413)2.42489186
130telomere maintenance via recombination (GO:0000722)2.42419462
131DNA strand elongation involved in DNA replication (GO:0006271)2.40423665
132serine family amino acid biosynthetic process (GO:0009070)2.38885367
133protein targeting to membrane (GO:0006612)2.38534344
134AMP metabolic process (GO:0046033)2.36596510
135nucleobase-containing small molecule interconversion (GO:0015949)2.36350460
136protein autoprocessing (GO:0016540)2.35187520
137porphyrin-containing compound biosynthetic process (GO:0006779)2.34963327
138mitochondrial calcium ion transport (GO:0006851)2.33725976
139ribosomal large subunit biogenesis (GO:0042273)2.32625520
140nucleoside salvage (GO:0043174)2.31934417
141anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.31809684
142protoporphyrinogen IX metabolic process (GO:0046501)2.30364727
143negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.29763734
144pseudouridine synthesis (GO:0001522)2.29154309
145membrane raft organization (GO:0031579)2.28887400
146respiratory burst (GO:0045730)2.28092264
147viral life cycle (GO:0019058)2.27963039
148DNA strand elongation (GO:0022616)2.27122594
149regulation of cellular amine metabolic process (GO:0033238)2.26964906
150positive regulation of cell cycle arrest (GO:0071158)2.26433067
151positive regulation of ligase activity (GO:0051351)2.24763152
152complement activation, classical pathway (GO:0006958)2.23079186
153positive regulation of macrophage differentiation (GO:0045651)2.21938945
154ribonucleoprotein complex biogenesis (GO:0022613)2.20782223
155lipopolysaccharide biosynthetic process (GO:0009103)2.19882949
156protein targeting to mitochondrion (GO:0006626)2.19059125
157positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.18603851

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96925747
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.20754994
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.16618870
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12059083
5E2F7_22180533_ChIP-Seq_HELA_Human3.02383157
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.96379331
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78837412
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.65881944
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.62970385
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.57114792
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.53341840
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.51235200
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.48625976
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39393902
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31389774
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28157586
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20813911
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.09765152
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.06566691
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.03921374
21* DCP1A_22483619_ChIP-Seq_HELA_Human2.00698749
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00269855
23VDR_23849224_ChIP-Seq_CD4+_Human1.99302118
24FOXM1_23109430_ChIP-Seq_U2OS_Human1.92489477
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90420951
26IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87946995
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84790216
28* SRF_21415370_ChIP-Seq_HL-1_Mouse1.83004034
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79047332
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75962347
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.74053899
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73878708
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72657277
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.68024833
35GABP_19822575_ChIP-Seq_HepG2_Human1.65783514
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65474474
37PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63707587
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.62568003
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61711509
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59173603
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57092410
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.56708708
43FOXP3_21729870_ChIP-Seq_TREG_Human1.56202376
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.56043914
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55100874
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54898527
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54541414
48XRN2_22483619_ChIP-Seq_HELA_Human1.54471617
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54276839
50ELK1_19687146_ChIP-ChIP_HELA_Human1.54185608
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52786786
52NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.51143470
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50863024
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50571918
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48987216
56PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47786088
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47318271
58SPI1_23547873_ChIP-Seq_NB4_Human1.46148522
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.44821177
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.44650780
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41478060
62PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40102677
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39989527
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37586814
65GATA1_22025678_ChIP-Seq_K562_Human1.37482588
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.36842129
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35251632
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.33156033
69ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32352640
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31725296
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31599743
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30385851
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28569892
74DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27477437
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27053252
76EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25058586
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25038736
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24571623
79NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24295572
80* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23838951
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23398197
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.23208099
83YY1_21170310_ChIP-Seq_MESCs_Mouse1.20790154
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.19785625
85ZNF263_19887448_ChIP-Seq_K562_Human1.19595313
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.17704123
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17427025
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17422703
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17383468
90CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.16927581
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.16877014
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16793437
93TFEB_21752829_ChIP-Seq_HELA_Human1.16647118
94BRD4_25478319_ChIP-Seq_HGPS_Human1.16399343
95MYB_26560356_Chip-Seq_TH2_Human1.15752559
96TTF2_22483619_ChIP-Seq_HELA_Human1.14712783
97* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14020270
98MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12310413
99ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12199878
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09305633
101* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08023916
102AR_21909140_ChIP-Seq_LNCAP_Human1.06246184
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06148730
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06089672
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04715206
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04064544
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03783396
108VDR_21846776_ChIP-Seq_THP-1_Human1.03504132
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.02028712
110IRF8_27001747_Chip-Seq_BMDM_Mouse1.01124044
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00394311
112MYB_26560356_Chip-Seq_TH1_Human1.00271489
113* RUNX1_22412390_ChIP-Seq_EML_Mouse1.00035585
114MAF_26560356_Chip-Seq_TH1_Human0.99791569
115MYC_18940864_ChIP-ChIP_HL60_Human0.99390296
116E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99006268
117* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98883286
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98539890
119TRIM28_21343339_ChIP-Seq_HEK293_Human0.98078211
120FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97862689
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96938525
122KDM5A_27292631_Chip-Seq_BREAST_Human0.96670902
123ELF5_23300383_ChIP-Seq_T47D_Human0.96651749
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96472778
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96454928
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96388767
127MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95755867
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95644561
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95439880
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95408013
131STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93953143
132IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.93719483
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91764328
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91420436
135EOMES_21245162_ChIP-Seq_HESCs_Human0.88930834
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86803495
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86803495
138SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85017485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.33950828
2MP0008438_abnormal_cutaneous_collagen3.56287205
3MP0003656_abnormal_erythrocyte_physiolo3.36441369
4MP0003941_abnormal_skin_development3.21373788
5MP0004272_abnormal_basement_membrane3.17910331
6MP0003186_abnormal_redox_activity3.09920853
7MP0003718_maternal_effect2.82128481
8MP0008058_abnormal_DNA_repair2.63486785
9MP0001835_abnormal_antigen_presentation2.59869576
10MP0006054_spinal_hemorrhage2.44075942
11MP0008007_abnormal_cellular_replicative2.39493861
12MP0003436_decreased_susceptibility_to2.30283762
13MP0003786_premature_aging2.30091243
14MP0010094_abnormal_chromosome_stability2.24213752
15MP0003724_increased_susceptibility_to2.23493836
16MP0003111_abnormal_nucleus_morphology2.23424112
17MP0008932_abnormal_embryonic_tissue2.19263765
18MP0002933_joint_inflammation2.15366121
19MP0005083_abnormal_biliary_tract2.13461759
20MP0009785_altered_susceptibility_to2.05317293
21MP0005671_abnormal_response_to2.04945981
22MP0009333_abnormal_splenocyte_physiolog1.99831382
23MP0003077_abnormal_cell_cycle1.96699376
24MP0002139_abnormal_hepatobiliary_system1.93157026
25MP0005000_abnormal_immune_tolerance1.83643034
26MP0000685_abnormal_immune_system1.80931801
27MP0003195_calcinosis1.78453762
28MP0005025_abnormal_response_to1.73223113
29MP0001533_abnormal_skeleton_physiology1.71638685
30MP0009840_abnormal_foam_cell1.71340011
31MP0002148_abnormal_hypersensitivity_rea1.69595442
32MP0005275_abnormal_skin_tensile1.65126774
33MP0009780_abnormal_chondrocyte_physiolo1.63583032
34MP0002419_abnormal_innate_immunity1.63140756
35MP0003693_abnormal_embryo_hatching1.60254807
36MP0005503_abnormal_tendon_morphology1.57520707
37MP0005058_abnormal_lysosome_morphology1.56245850
38MP0003763_abnormal_thymus_physiology1.52736424
39MP0002723_abnormal_immune_serum1.52524621
40MP0001853_heart_inflammation1.52259225
41MP0005257_abnormal_intraocular_pressure1.50240620
42MP0001542_abnormal_bone_strength1.50033732
43MP0010368_abnormal_lymphatic_system1.49915420
44MP0002452_abnormal_antigen_presenting1.48070264
45MP0001800_abnormal_humoral_immune1.47732785
46MP0006082_CNS_inflammation1.46670231
47MP0002166_altered_tumor_susceptibility1.46666212
48MP0010030_abnormal_orbit_morphology1.45688669
49MP0004147_increased_porphyrin_level1.44954574
50MP0002405_respiratory_system_inflammati1.44547527
51MP0000343_altered_response_to1.43930198
52MP0008469_abnormal_protein_level1.41924698
53MP0005360_urolithiasis1.41845483
54MP0005395_other_phenotype1.39514593
55MP0002420_abnormal_adaptive_immunity1.38050632
56MP0002006_tumorigenesis1.35980036
57MP0001819_abnormal_immune_cell1.35503604
58MP0000858_altered_metastatic_potential1.35159603
59MP0001790_abnormal_immune_system1.34838568
60MP0005387_immune_system_phenotype1.34838568
61MP0008775_abnormal_heart_ventricle1.34268082
62MP0005464_abnormal_platelet_physiology1.32219844
63MP0002398_abnormal_bone_marrow1.31948395
64MP0001845_abnormal_inflammatory_respons1.31689711
65MP0009764_decreased_sensitivity_to1.29114221
66MP0003705_abnormal_hypodermis_morpholog1.27987365
67MP0001243_abnormal_dermal_layer1.27358566
68MP0002396_abnormal_hematopoietic_system1.26910793
69MP0003279_aneurysm1.26213181
70MP0005330_cardiomyopathy1.26043952
71MP0000689_abnormal_spleen_morphology1.24574465
72MP0008057_abnormal_DNA_replication1.24296206
73MP0003191_abnormal_cellular_cholesterol1.23744436
74MP0001730_embryonic_growth_arrest1.23539147
75MP0006036_abnormal_mitochondrial_physio1.22152622
76MP0005085_abnormal_gallbladder_physiolo1.21538549
77MP0005023_abnormal_wound_healing1.21455986
78MP0001545_abnormal_hematopoietic_system1.21018172
79MP0005397_hematopoietic_system_phenotyp1.21018172
80MP0004957_abnormal_blastocyst_morpholog1.20914629
81MP0000716_abnormal_immune_system1.20017433
82MP0000762_abnormal_tongue_morphology1.19657414
83MP0000350_abnormal_cell_proliferation1.19213931
84MP0005365_abnormal_bile_salt1.19119348
85MP0000751_myopathy1.16939139
86MP0002722_abnormal_immune_system1.16873579
87MP0005508_abnormal_skeleton_morphology1.16662068
88MP0002429_abnormal_blood_cell1.16313449
89MP0002877_abnormal_melanocyte_morpholog1.15504969
90MP0001661_extended_life_span1.15197898
91MP0009384_cardiac_valve_regurgitation1.14398869
92MP0001666_abnormal_nutrient_absorption1.10005802
93MP0010352_gastrointestinal_tract_polyps1.09970646
94MP0005319_abnormal_enzyme/_coenzyme1.07455418
95MP0005501_abnormal_skin_physiology1.06878826
96MP0001958_emphysema1.05504070
97MP0004947_skin_inflammation1.03474502
98MP0005390_skeleton_phenotype1.02406441
99MP0005636_abnormal_mineral_homeostasis1.01670275
100MP0005332_abnormal_amino_acid1.01315097
101MP0000490_abnormal_crypts_of0.99433923
102MP0001299_abnormal_eye_distance/0.98913311
103MP0002938_white_spotting0.98077070
104MP0005220_abnormal_exocrine_pancreas0.97658330
105MP0004084_abnormal_cardiac_muscle0.97508160
106MP0001697_abnormal_embryo_size0.97292073
107MP0005584_abnormal_enzyme/coenzyme_acti0.97063755
108MP0009643_abnormal_urine_homeostasis0.96529814
109MP0009763_increased_sensitivity_to0.94945289
110MP0006035_abnormal_mitochondrial_morpho0.94709281
111MP0001764_abnormal_homeostasis0.94436115
112MP0000609_abnormal_liver_physiology0.93404661
113MP0002132_abnormal_respiratory_system0.92120493
114MP0010155_abnormal_intestine_physiology0.91604889
115MP0002019_abnormal_tumor_incidence0.91191093
116MP0002080_prenatal_lethality0.90579530
117MP0005623_abnormal_meninges_morphology0.89851938
118MP0001672_abnormal_embryogenesis/_devel0.89408676
119MP0005380_embryogenesis_phenotype0.89408676
120MP0001881_abnormal_mammary_gland0.89221124
121MP0009697_abnormal_copulation0.88301079
122MP0002160_abnormal_reproductive_system0.88019213
123MP0009250_abnormal_appendicular_skeleto0.87770871
124MP0000372_irregular_coat_pigmentation0.87612442
125MP0000516_abnormal_urinary_system0.86954303
126MP0005367_renal/urinary_system_phenotyp0.86954303
127MP0001529_abnormal_vocalization0.86823175
128MP0002282_abnormal_trachea_morphology0.86624404
129MP0003795_abnormal_bone_structure0.86285590
130MP0002108_abnormal_muscle_morphology0.85470269
131MP0000749_muscle_degeneration0.85178367
132MP0003448_altered_tumor_morphology0.85003226
133MP0008789_abnormal_olfactory_epithelium0.83686849
134MP0005408_hypopigmentation0.83389290
135MP0005084_abnormal_gallbladder_morpholo0.82888538
136MP0003950_abnormal_plasma_membrane0.82667647
137MP0000598_abnormal_liver_morphology0.82524998
138MP0010234_abnormal_vibrissa_follicle0.81454341
139MP0000358_abnormal_cell_content/0.81438283
140MP0002295_abnormal_pulmonary_circulatio0.81176049
141MP0008875_abnormal_xenobiotic_pharmacok0.80426501
142MP0005165_increased_susceptibility_to0.79286848
143MP0003984_embryonic_growth_retardation0.78798374
144MP0002254_reproductive_system_inflammat0.78560906
145MP0002060_abnormal_skin_morphology0.78297252
146MP0002796_impaired_skin_barrier0.76946728
147MP0008873_increased_physiological_sensi0.76846170
148MP0010771_integument_phenotype0.75248520
149MP0005451_abnormal_body_composition0.75081195
150MP0002088_abnormal_embryonic_growth/wei0.74753012
151MP0003566_abnormal_cell_adhesion0.74740940
152MP0002084_abnormal_developmental_patter0.74510683
153MP0001879_abnormal_lymphatic_vessel0.73735672
154MP0002085_abnormal_embryonic_tissue0.71878940
155MP0010307_abnormal_tumor_latency0.70616147
156MP0004215_abnormal_myocardial_fiber0.70275072
157MP0000313_abnormal_cell_death0.68051030
158MP0000013_abnormal_adipose_tissue0.67920731
159MP0000750_abnormal_muscle_regeneration0.67530448
160MP0005384_cellular_phenotype0.65992344
161MP0002210_abnormal_sex_determination0.65278605
162MP0002269_muscular_atrophy0.64856249
163MP0009053_abnormal_anal_canal0.62128879
164MP0002086_abnormal_extraembryonic_tissu0.61336215
165MP0002177_abnormal_outer_ear0.59786586
166MP0005621_abnormal_cell_physiology0.58998733
167MP0010386_abnormal_urinary_bladder0.58924954
168MP0003937_abnormal_limbs/digits/tail_de0.58066022

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)3.63641560
2Progressive macrocephaly (HP:0004481)3.38209709
3Vertebral compression fractures (HP:0002953)3.33614399
4Beaking of vertebral bodies (HP:0004568)3.09041282
5Irregular epiphyses (HP:0010582)3.01573801
6Abnormality of the heme biosynthetic pathway (HP:0010472)3.00547430
7Abnormality of cells of the erythroid lineage (HP:0012130)3.00366964
8Abnormal number of erythroid precursors (HP:0012131)2.95186332
9Rough bone trabeculation (HP:0100670)2.95153584
10Abnormal gallbladder physiology (HP:0012438)2.91390248
11Cholecystitis (HP:0001082)2.91390248
12Reduced subcutaneous adipose tissue (HP:0003758)2.90796995
13Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89763889
14Decreased activity of mitochondrial respiratory chain (HP:0008972)2.87190989
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.87190989
16Increased serum pyruvate (HP:0003542)2.86809726
17Entropion (HP:0000621)2.82949335
18Protrusio acetabuli (HP:0003179)2.79953467
19Ankle contracture (HP:0006466)2.72081862
20Aortic dissection (HP:0002647)2.71089168
21Petechiae (HP:0000967)2.69298549
22Cerebral edema (HP:0002181)2.68035733
23Renal Fanconi syndrome (HP:0001994)2.65476363
24Hepatic necrosis (HP:0002605)2.64900174
25Hepatocellular necrosis (HP:0001404)2.64083464
26Abnormality of glycolysis (HP:0004366)2.62172012
27Testicular atrophy (HP:0000029)2.61860110
28Poor head control (HP:0002421)2.60266788
29IgM deficiency (HP:0002850)2.57131978
30Palpitations (HP:0001962)2.56103676
31Follicular hyperkeratosis (HP:0007502)2.52446742
32Soft skin (HP:0000977)2.48822806
33Abnormal tarsal ossification (HP:0008369)2.47763638
34Vacuolated lymphocytes (HP:0001922)2.44006994
35Abnormality of dentin (HP:0010299)2.43382504
36Sparse eyelashes (HP:0000653)2.42198475
37Exercise intolerance (HP:0003546)2.41854955
38Recurrent bronchitis (HP:0002837)2.41626013
39Premature rupture of membranes (HP:0001788)2.39904030
40Increased serum ferritin (HP:0003281)2.37855023
41Reduced antithrombin III activity (HP:0001976)2.36507544
42Abnormality of the umbilical cord (HP:0010881)2.35069737
43Microglossia (HP:0000171)2.35014775
44Type I transferrin isoform profile (HP:0003642)2.34407199
45Eczematoid dermatitis (HP:0000976)2.29023954
463-Methylglutaconic aciduria (HP:0003535)2.27347456
47Nonimmune hydrops fetalis (HP:0001790)2.23576035
48Chronic otitis media (HP:0000389)2.22810433
49Mitochondrial inheritance (HP:0001427)2.22200237
50Oral leukoplakia (HP:0002745)2.21761831
51Joint stiffness (HP:0001387)2.21375945
52Atrophic scars (HP:0001075)2.20938470
53Trismus (HP:0000211)2.20523094
54Vascular tortuosity (HP:0004948)2.19834988
55Purpura (HP:0000979)2.19190364
56Short middle phalanx of the 5th finger (HP:0004220)2.17749688
57Aplastic anemia (HP:0001915)2.17527563
58Abnormality of placental membranes (HP:0011409)2.17173290
59Amniotic constriction ring (HP:0009775)2.17173290
60Increased muscle lipid content (HP:0009058)2.15421298
61Aortic aneurysm (HP:0004942)2.15196293
62Secondary amenorrhea (HP:0000869)2.14990788
63Cervical subluxation (HP:0003308)2.14800932
64Increased intramyocellular lipid droplets (HP:0012240)2.14561891
65Abnormalities of placenta or umbilical cord (HP:0001194)2.13809350
66Sensory axonal neuropathy (HP:0003390)2.13575731
67Respiratory failure (HP:0002878)2.12535918
68Abnormal hemoglobin (HP:0011902)2.11880845
69B lymphocytopenia (HP:0010976)2.11838606
70Abnormality of B cell number (HP:0010975)2.11838606
71Glucose intolerance (HP:0000833)2.11764316
72Abnormal delivery (HP:0001787)2.11064014
73Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10720288
74Abnormal protein N-linked glycosylation (HP:0012347)2.10720288
75Abnormal protein glycosylation (HP:0012346)2.10720288
76Abnormal glycosylation (HP:0012345)2.10720288
77Abnormality of T cell physiology (HP:0011840)2.09968908
78Fragile skin (HP:0001030)2.06205426
79Exertional dyspnea (HP:0002875)2.05642789
80Steatorrhea (HP:0002570)2.03154144
81Abnormal trabecular bone morphology (HP:0100671)2.02616499
82Increased CSF lactate (HP:0002490)2.02518388
83Lipid accumulation in hepatocytes (HP:0006561)2.02287491
84Abnormality of iron homeostasis (HP:0011031)2.01762766
85Cupped ribs (HP:0000887)2.01686579
86Biconcave vertebral bodies (HP:0004586)2.01634466
87Abnormal foot bone ossification (HP:0010675)2.00953228
88Recurrent abscess formation (HP:0002722)2.00878041
89Epiphyseal dysplasia (HP:0002656)1.99960884
90Degeneration of anterior horn cells (HP:0002398)1.99769105
91Abnormality of the anterior horn cell (HP:0006802)1.99769105
92Opisthotonus (HP:0002179)1.99113205
93Peritonitis (HP:0002586)1.97807209
94Autoamputation (HP:0001218)1.97783552
95Spinal rigidity (HP:0003306)1.96443592
96Thrombocytosis (HP:0001894)1.96050314
97Cerebral hypomyelination (HP:0006808)1.95895067
98Increased serum lactate (HP:0002151)1.94598487
99Axonal loss (HP:0003447)1.93995159
100Microcytic anemia (HP:0001935)1.93481059
101Microvesicular hepatic steatosis (HP:0001414)1.92429372
102Abnormality of the lumbar spine (HP:0100712)1.91652118
103Adrenal hypoplasia (HP:0000835)1.91066619
104Increased hepatocellular lipid droplets (HP:0006565)1.90486516
105Breech presentation (HP:0001623)1.89978733
106Acute necrotizing encephalopathy (HP:0006965)1.89650854
107Coxa vara (HP:0002812)1.89504674
108Myocardial infarction (HP:0001658)1.88842920
109Congenital, generalized hypertrichosis (HP:0004540)1.88096063
110Cardiovascular calcification (HP:0011915)1.87180014
111Hepatosplenomegaly (HP:0001433)1.86660701
112Delayed gross motor development (HP:0002194)1.86198068
113Elbow flexion contracture (HP:0002987)1.86008701
114Wormian bones (HP:0002645)1.85939389
115Abnormality of transition element cation homeostasis (HP:0011030)1.85929410
116Abnormal mitochondria in muscle tissue (HP:0008316)1.85783227
117Methylmalonic acidemia (HP:0002912)1.85189993
118Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85049178
119Metaphyseal dysplasia (HP:0100255)1.84888310
120Abnormality of methionine metabolism (HP:0010901)1.84803235
121Protuberant abdomen (HP:0001538)1.84574220
122Abnormality of T cells (HP:0002843)1.84285466
123Recurrent bacterial skin infections (HP:0005406)1.84177208
124Recurrent gram-negative bacterial infections (HP:0005420)1.83220280
125Abnormal umbilical cord blood vessels (HP:0011403)1.82878477
126Single umbilical artery (HP:0001195)1.82878477
127Abnormality of the fetal cardiovascular system (HP:0010948)1.82878477
128Acute encephalopathy (HP:0006846)1.82864963
129Vascular calcification (HP:0004934)1.82745406
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82619696
131Recurrent pneumonia (HP:0006532)1.82529913
132Xanthomatosis (HP:0000991)1.81962282
133Redundant skin (HP:0001582)1.81904611
134Nausea (HP:0002018)1.81875939
135Abnormal spermatogenesis (HP:0008669)1.81238012
136Abnormality of the intrinsic pathway (HP:0010989)1.79983809
137Abnormality of macrophages (HP:0004311)1.79973504
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.79518076
139Osteolytic defects of the hand bones (HP:0009699)1.79187417
140Osteolytic defects of the phalanges of the hand (HP:0009771)1.79187417
141Lactic acidosis (HP:0003128)1.78713113
142Generalized amyotrophy (HP:0003700)1.78589763
143Macrocytic anemia (HP:0001972)1.78282404
144Irregular vertebral endplates (HP:0003301)1.77715041
145Interstitial pulmonary disease (HP:0006530)1.77692786
146Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76473589
147Short nail (HP:0001799)1.76389486
148Myositis (HP:0100614)1.75932775
149Upper limb muscle weakness (HP:0003484)1.75441313
150T lymphocytopenia (HP:0005403)1.74987263
151Hypergammaglobulinemia (HP:0010702)1.74319802
152Hypokinesia (HP:0002375)1.73532455
153Abnormal gallbladder morphology (HP:0012437)1.72839730
154Multiple enchondromatosis (HP:0005701)1.72636018
155Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72469697
156Arterial tortuosity (HP:0005116)1.72384344
157Abnormality of T cell number (HP:0011839)1.72255996
158Congenital ichthyosiform erythroderma (HP:0007431)1.71349911
159Abnormality of the common coagulation pathway (HP:0010990)1.70670151
160Onycholysis (HP:0001806)1.70476453
161Cholelithiasis (HP:0001081)1.70024509
162Erythema (HP:0010783)1.69575408
163Diaphragmatic weakness (HP:0009113)1.69570027
164Pallor (HP:0000980)1.69528556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.72789414
2EIF2AK13.96083620
3VRK23.78230537
4PIM23.11129837
5TESK23.07734376
6NEK13.02754730
7ERN12.81684044
8KDR2.73523236
9EIF2AK32.46027357
10MAP4K12.38071923
11BLK2.35446028
12PBK2.35282650
13ZAP702.11682413
14TESK12.10989194
15STK162.08322425
16TTK2.04781805
17MAP3K112.02629084
18SCYL21.98927421
19PLK31.93112643
20BCKDK1.92066394
21BUB11.90969392
22TSSK61.90054958
23PAK41.82095555
24TBK11.81089155
25LIMK11.80274727
26SRPK11.70778313
27NUAK11.68451882
28MST41.63146842
29JAK31.46011511
30IRAK41.38053033
31ABL21.37808432
32NEK91.36823848
33EPHA21.32034768
34PIK3CG1.28810597
35MAPKAPK31.25933955
36LRRK21.23443409
37TAF11.20852587
38PTK21.20714537
39MAPKAPK51.19831632
40RPS6KA41.19823213
41MAP3K141.18855081
42PLK11.17161824
43TRPM71.15626648
44MAP2K31.13406921
45FLT31.12663469
46BRSK11.12065037
47MAP3K31.11884935
48TXK1.09342351
49EPHB11.08528345
50TYK21.07816237
51ERBB41.07020099
52NME11.03411975
53ZAK1.01388028
54IKBKE0.97888336
55TEC0.97498728
56IRAK30.96805200
57CLK10.92775631
58MST1R0.91826874
59ACVR1B0.91036611
60NLK0.89611751
61DAPK10.87180517
62ARAF0.87048072
63ILK0.84544940
64TRIM280.80357590
65BRAF0.80225207
66KIT0.79734953
67STK100.79475946
68MYLK0.79157976
69CDK80.77924137
70TRIB30.75678110
71PRKG20.75300005
72VRK10.75281019
73TGFBR20.75258309
74IRAK10.74893438
75STK30.74274393
76NEK20.73843575
77IKBKB0.73022675
78EIF2AK20.71681287
79FER0.71126261
80PIM10.70702831
81SYK0.70487690
82PAK20.69949022
83BRSK20.68964610
84BMPR1B0.68545453
85PLK20.67446246
86ERBB30.66860244
87MUSK0.66190546
88CDC70.63762603
89LYN0.63447301
90MAP3K80.62510140
91CHEK20.61936701
92PRKCI0.61277502
93BTK0.60261602
94MOS0.58819526
95WEE10.57727144
96RPS6KB20.57657736
97LCK0.57412014
98LMTK20.56598752
99TLK10.56346775
100MAP3K50.53954307
101MET0.53157069
102MKNK20.52497160
103DMPK0.52206085
104CSF1R0.50915535
105CSNK1G10.49299586
106CSK0.48933859
107PAK10.48765747
108TIE10.48488358
109DDR20.48453818
110AURKA0.47848782
111MAPKAPK20.47718774
112STK38L0.46894324
113MAP4K20.44354059
114DAPK30.43338094
115CSNK1G30.43315483
116PLK40.43047996
117CHEK10.42207480
118TAOK30.41461717
119RPS6KA50.41264667
120JAK10.41237866
121PTK2B0.40612589
122ITK0.38707345
123STK390.38523748
124MKNK10.38082048
125CSNK2A10.38053517
126LATS10.37680130
127AURKB0.37305274
128ATM0.36985851
129MAP3K120.35873263
130ROCK10.35820258
131MAP2K20.35514940
132CDK70.35460491
133PRKCD0.35387739
134ATR0.33088151
135TGFBR10.32991759
136ROCK20.32616749
137CSNK1A1L0.32261837
138TAOK20.31004660
139PDK20.30839804
140TTN0.30278400
141ABL10.28971719
142CSNK2A20.26877612
143MATK0.26608090
144MAP3K60.24845710
145BMX0.24507538
146FGFR40.24034665
147DYRK20.23917822
148RAF10.23814583
149STK40.23710873

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.99475683
2Proteasome_Homo sapiens_hsa030503.98713741
3Ribosome_Homo sapiens_hsa030103.11813664
4DNA replication_Homo sapiens_hsa030302.65840279
5Folate biosynthesis_Homo sapiens_hsa007902.45795592
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.11557667
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.08986765
8Steroid biosynthesis_Homo sapiens_hsa001002.01638383
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78735024
10Sulfur relay system_Homo sapiens_hsa041221.78598002
11RNA polymerase_Homo sapiens_hsa030201.78562331
12Basal transcription factors_Homo sapiens_hsa030221.77732848
13Pyrimidine metabolism_Homo sapiens_hsa002401.72482834
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.64096380
15Mismatch repair_Homo sapiens_hsa034301.55112570
16Oxidative phosphorylation_Homo sapiens_hsa001901.54427937
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47188807
18* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44639420
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44301551
20Parkinsons disease_Homo sapiens_hsa050121.43641616
21Cell cycle_Homo sapiens_hsa041101.43178207
22Nucleotide excision repair_Homo sapiens_hsa034201.35841120
23Base excision repair_Homo sapiens_hsa034101.34682240
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34274372
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29942176
26One carbon pool by folate_Homo sapiens_hsa006701.28831960
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28645993
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.25706079
29Glutathione metabolism_Homo sapiens_hsa004801.23081553
30Primary immunodeficiency_Homo sapiens_hsa053401.21623422
31Caffeine metabolism_Homo sapiens_hsa002321.21261933
32Fanconi anemia pathway_Homo sapiens_hsa034601.15542042
33Fatty acid elongation_Homo sapiens_hsa000621.13740847
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13549037
35Malaria_Homo sapiens_hsa051441.10979796
36Primary bile acid biosynthesis_Homo sapiens_hsa001201.09644291
37Vitamin B6 metabolism_Homo sapiens_hsa007501.09564658
38Sulfur metabolism_Homo sapiens_hsa009201.08716174
39Pentose phosphate pathway_Homo sapiens_hsa000301.05169897
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.04434502
41Homologous recombination_Homo sapiens_hsa034401.03545388
42N-Glycan biosynthesis_Homo sapiens_hsa005101.02023594
43Legionellosis_Homo sapiens_hsa051341.01911125
44Peroxisome_Homo sapiens_hsa041461.00750190
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95402698
46Selenocompound metabolism_Homo sapiens_hsa004500.94786905
47Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92879855
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91800760
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90656712
50Arginine and proline metabolism_Homo sapiens_hsa003300.88048664
51Antigen processing and presentation_Homo sapiens_hsa046120.85664151
52Hematopoietic cell lineage_Homo sapiens_hsa046400.84808903
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84542294
54Histidine metabolism_Homo sapiens_hsa003400.84387865
55Asthma_Homo sapiens_hsa053100.84051018
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84046522
57Pyruvate metabolism_Homo sapiens_hsa006200.83797135
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83500244
59ECM-receptor interaction_Homo sapiens_hsa045120.83237233
60Leishmaniasis_Homo sapiens_hsa051400.82856797
61Shigellosis_Homo sapiens_hsa051310.82581894
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81826881
63Biosynthesis of amino acids_Homo sapiens_hsa012300.81708928
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.81059864
65Huntingtons disease_Homo sapiens_hsa050160.79828948
66Spliceosome_Homo sapiens_hsa030400.79012189
67Staphylococcus aureus infection_Homo sapiens_hsa051500.78835886
68Allograft rejection_Homo sapiens_hsa053300.77918354
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77149697
70Alzheimers disease_Homo sapiens_hsa050100.77123464
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75831641
72Chemical carcinogenesis_Homo sapiens_hsa052040.75319920
73Other glycan degradation_Homo sapiens_hsa005110.74810441
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73670154
75Non-homologous end-joining_Homo sapiens_hsa034500.73131250
76Graft-versus-host disease_Homo sapiens_hsa053320.72110370
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71739912
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71722656
79Lysosome_Homo sapiens_hsa041420.69911395
80Complement and coagulation cascades_Homo sapiens_hsa046100.69762701
81Purine metabolism_Homo sapiens_hsa002300.69022349
82p53 signaling pathway_Homo sapiens_hsa041150.68668764
83RNA transport_Homo sapiens_hsa030130.68243495
84Measles_Homo sapiens_hsa051620.67894201
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66872131
86Metabolic pathways_Homo sapiens_hsa011000.66848232
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66773809
88Oocyte meiosis_Homo sapiens_hsa041140.66743976
89Phagosome_Homo sapiens_hsa041450.66724013
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66506117
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66353722
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.65359750
93Pertussis_Homo sapiens_hsa051330.64352575
94Cardiac muscle contraction_Homo sapiens_hsa042600.64196997
95Carbon metabolism_Homo sapiens_hsa012000.64184383
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64083869
97TGF-beta signaling pathway_Homo sapiens_hsa043500.58870266
98RNA degradation_Homo sapiens_hsa030180.58152090
99Apoptosis_Homo sapiens_hsa042100.55206168
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53146005
101Fatty acid degradation_Homo sapiens_hsa000710.52474928
102Propanoate metabolism_Homo sapiens_hsa006400.50611518
103Galactose metabolism_Homo sapiens_hsa000520.50543237
104Epstein-Barr virus infection_Homo sapiens_hsa051690.49320394
105Thyroid cancer_Homo sapiens_hsa052160.48553910
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.48235819
107Tyrosine metabolism_Homo sapiens_hsa003500.47828694
108Herpes simplex infection_Homo sapiens_hsa051680.44711772
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44448855
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43146592
111Fatty acid metabolism_Homo sapiens_hsa012120.42547141
112Protein digestion and absorption_Homo sapiens_hsa049740.42493844
113Rheumatoid arthritis_Homo sapiens_hsa053230.41976471
114Vibrio cholerae infection_Homo sapiens_hsa051100.41089645
115Tryptophan metabolism_Homo sapiens_hsa003800.39995892
116beta-Alanine metabolism_Homo sapiens_hsa004100.39454619
117mRNA surveillance pathway_Homo sapiens_hsa030150.39433813
118Phenylalanine metabolism_Homo sapiens_hsa003600.39077752
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38900480
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38014458
121Fructose and mannose metabolism_Homo sapiens_hsa000510.33284034
122Focal adhesion_Homo sapiens_hsa045100.32323925
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28000570
124Small cell lung cancer_Homo sapiens_hsa052220.27689938
125Adherens junction_Homo sapiens_hsa045200.24043596
126Proteoglycans in cancer_Homo sapiens_hsa052050.23274213
127Glycosaminoglycan degradation_Homo sapiens_hsa005310.20686288
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20341830
129Butanoate metabolism_Homo sapiens_hsa006500.19886742
130Hippo signaling pathway_Homo sapiens_hsa043900.18126299
131Mineral absorption_Homo sapiens_hsa049780.17129202
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16925602
133Arginine biosynthesis_Homo sapiens_hsa002200.16283066

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