RFC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA strand elongation involved in DNA replication (GO:0006271)5.71128866
2* telomere maintenance via semi-conservative replication (GO:0032201)5.51169994
3* DNA strand elongation (GO:0022616)5.42428829
4DNA replication initiation (GO:0006270)5.36524522
5ribosomal small subunit assembly (GO:0000028)5.28197169
6mitotic sister chromatid segregation (GO:0000070)5.03488825
7* telomere maintenance via recombination (GO:0000722)5.02926598
8DNA unwinding involved in DNA replication (GO:0006268)4.86671120
9nuclear pore complex assembly (GO:0051292)4.83131426
10sister chromatid segregation (GO:0000819)4.78313778
11* mitotic recombination (GO:0006312)4.76009443
12DNA replication checkpoint (GO:0000076)4.65693967
13maturation of SSU-rRNA (GO:0030490)4.62181257
14viral transcription (GO:0019083)4.44202184
15nuclear pore organization (GO:0006999)4.42938785
16CENP-A containing nucleosome assembly (GO:0034080)4.38160995
17DNA deamination (GO:0045006)4.30457551
18translational termination (GO:0006415)4.30400383
19* nucleotide-excision repair, DNA gap filling (GO:0006297)4.29551317
20mitotic sister chromatid cohesion (GO:0007064)4.28212018
21chromatin remodeling at centromere (GO:0031055)4.28055865
22* telomere maintenance via telomere lengthening (GO:0010833)4.25982906
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.24463547
24ribosomal small subunit biogenesis (GO:0042274)4.12510248
25DNA ligation (GO:0006266)4.04753273
26kinetochore organization (GO:0051383)4.01342245
27DNA replication-independent nucleosome organization (GO:0034724)3.99233366
28DNA replication-independent nucleosome assembly (GO:0006336)3.99233366
29ribosomal large subunit biogenesis (GO:0042273)3.95672552
30formation of translation preinitiation complex (GO:0001731)3.94011704
31protein localization to kinetochore (GO:0034501)3.92815781
32DNA replication-dependent nucleosome organization (GO:0034723)3.91653812
33DNA replication-dependent nucleosome assembly (GO:0006335)3.91653812
34regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.91412989
35nucleobase biosynthetic process (GO:0046112)3.88674868
36translational elongation (GO:0006414)3.87717776
37DNA topological change (GO:0006265)3.83330896
38mitotic metaphase plate congression (GO:0007080)3.82598346
39spindle checkpoint (GO:0031577)3.80599534
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.79448260
41negative regulation of chromosome segregation (GO:0051985)3.78916558
42SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.77623733
43negative regulation of mitotic sister chromatid separation (GO:2000816)3.73502687
44negative regulation of sister chromatid segregation (GO:0033046)3.73502687
45negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.73502687
46negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.73502687
47negative regulation of mitotic sister chromatid segregation (GO:0033048)3.73502687
48purine nucleobase biosynthetic process (GO:0009113)3.72689142
49mitotic spindle checkpoint (GO:0071174)3.69442035
50kinetochore assembly (GO:0051382)3.69344220
51cotranslational protein targeting to membrane (GO:0006613)3.68550488
52translational initiation (GO:0006413)3.67218726
53regulation of chromosome segregation (GO:0051983)3.66496949
54protein targeting to ER (GO:0045047)3.65948617
55establishment of viral latency (GO:0019043)3.64988242
56regulation of centriole replication (GO:0046599)3.57893285
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.57837320
58mitotic spindle assembly checkpoint (GO:0007094)3.55354526
59non-recombinational repair (GO:0000726)3.54800261
60double-strand break repair via nonhomologous end joining (GO:0006303)3.54800261
61pore complex assembly (GO:0046931)3.53614014
62spindle assembly checkpoint (GO:0071173)3.53131618
63attachment of spindle microtubules to kinetochore (GO:0008608)3.52404300
64* transcription-coupled nucleotide-excision repair (GO:0006283)3.51575476
65regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.50634067
66regulation of mitotic metaphase/anaphase transition (GO:0030071)3.50634067
67histone exchange (GO:0043486)3.49693285
68metaphase plate congression (GO:0051310)3.49672118
69protein localization to chromosome, centromeric region (GO:0071459)3.47766310
70ribonucleoprotein complex biogenesis (GO:0022613)3.46681041
71spliceosomal snRNP assembly (GO:0000387)3.46056483
72establishment of protein localization to endoplasmic reticulum (GO:0072599)3.45916184
73IMP metabolic process (GO:0046040)3.45871515
74protein localization to endoplasmic reticulum (GO:0070972)3.45115727
75viral mRNA export from host cell nucleus (GO:0046784)3.43638289
76regulation of sister chromatid segregation (GO:0033045)3.42566757
77regulation of mitotic sister chromatid separation (GO:0010965)3.42566757
78regulation of mitotic sister chromatid segregation (GO:0033047)3.42566757
79chromosome segregation (GO:0007059)3.39535064
80cellular protein complex disassembly (GO:0043624)3.38803701
81viral life cycle (GO:0019058)3.38122370
82regulation of DNA endoreduplication (GO:0032875)3.36937928
83spliceosomal complex assembly (GO:0000245)3.34384335
84ATP-dependent chromatin remodeling (GO:0043044)3.30106128
85mismatch repair (GO:0006298)3.29064102
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.28933680
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.28933680
88DNA double-strand break processing (GO:0000729)3.28359177
89mitotic nuclear envelope disassembly (GO:0007077)3.27563305
90protein localization to chromosome (GO:0034502)3.27373326
91deoxyribonucleotide biosynthetic process (GO:0009263)3.27184831
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27132683
93positive regulation of chromosome segregation (GO:0051984)3.26943340
94cell cycle G1/S phase transition (GO:0044843)3.25370841
95G1/S transition of mitotic cell cycle (GO:0000082)3.25370841
96mitotic chromosome condensation (GO:0007076)3.24847975
97rRNA processing (GO:0006364)3.23943715
98regulation of double-strand break repair via homologous recombination (GO:0010569)3.22868827
99anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.22165472
100DNA catabolic process, exonucleolytic (GO:0000738)3.21606839
101chromosome condensation (GO:0030261)3.20189310
102regulation of helicase activity (GO:0051095)3.20044532
103regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19557649
104establishment of chromosome localization (GO:0051303)3.19019709
105synapsis (GO:0007129)3.18849611
106regulation of mitotic spindle checkpoint (GO:1903504)3.18798047
107regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18798047
108* telomere maintenance (GO:0000723)3.17848868
109* telomere organization (GO:0032200)3.17160121
110rRNA metabolic process (GO:0016072)3.13058262
111negative regulation of DNA-dependent DNA replication (GO:2000104)3.12537627
112positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.12329023
113meiotic chromosome segregation (GO:0045132)3.11932034
114heterochromatin organization (GO:0070828)3.11647209
115establishment of integrated proviral latency (GO:0075713)3.11242303
116regulation of nuclear cell cycle DNA replication (GO:0033262)3.10897929
117protein complex localization (GO:0031503)3.10188519
118protein K6-linked ubiquitination (GO:0085020)3.10026662
119regulation of spindle organization (GO:0090224)3.09965188
120IMP biosynthetic process (GO:0006188)3.09297357
121regulation of centrosome cycle (GO:0046605)3.08659628
122protein complex disassembly (GO:0043241)3.08166273
123base-excision repair (GO:0006284)3.07424170
124ribosome biogenesis (GO:0042254)3.07021692
125exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.05551719
126translation (GO:0006412)3.04675232
127maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03992811
128negative regulation of mitosis (GO:0045839)3.03447183
129nuclear-transcribed mRNA catabolic process (GO:0000956)3.03232960
130translesion synthesis (GO:0019985)3.02970801
131proteasome assembly (GO:0043248)3.01259336
132pseudouridine synthesis (GO:0001522)3.00120933
133chromatin assembly or disassembly (GO:0006333)2.99823851
134nuclear envelope disassembly (GO:0051081)2.98871991
135membrane disassembly (GO:0030397)2.98871991
136DNA duplex unwinding (GO:0032508)2.97516299
137DNA geometric change (GO:0032392)2.97133674
138folic acid-containing compound biosynthetic process (GO:0009396)2.96872904
139pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.96462845
140negative regulation of ligase activity (GO:0051352)2.96111070
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96111070
142macromolecular complex disassembly (GO:0032984)2.94384188
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93609058
144* DNA replication (GO:0006260)2.93207525
145pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91152298
146postreplication repair (GO:0006301)2.89377908
147ribosome assembly (GO:0042255)2.89064009
1487-methylguanosine mRNA capping (GO:0006370)2.89022887
149mRNA catabolic process (GO:0006402)2.87848129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.95395896
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.38227770
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.01616133
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65245186
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.58976443
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51920743
7* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21967290
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.16813637
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.08059669
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92145351
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89350859
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88275477
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84070152
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.80734356
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79291870
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72086359
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.56972769
18XRN2_22483619_ChIP-Seq_HELA_Human2.42108577
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34954368
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33175900
21VDR_23849224_ChIP-Seq_CD4+_Human2.31561893
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31409887
23* E2F1_21310950_ChIP-Seq_MCF-7_Human2.18481115
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16330929
25* DCP1A_22483619_ChIP-Seq_HELA_Human2.09903079
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.09019055
27* FOXP3_21729870_ChIP-Seq_TREG_Human2.07940912
28AR_21909140_ChIP-Seq_LNCAP_Human2.07640069
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06241996
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.00899613
31TTF2_22483619_ChIP-Seq_HELA_Human1.96872254
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.96246240
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89344866
34GABP_19822575_ChIP-Seq_HepG2_Human1.86804523
35ELK1_19687146_ChIP-ChIP_HELA_Human1.86234170
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85397587
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79551691
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76593673
39* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.75969412
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74121052
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68692532
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65773208
43CIITA_25753668_ChIP-Seq_RAJI_Human1.64428404
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63961916
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63655966
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.62496726
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59963538
48* SRF_21415370_ChIP-Seq_HL-1_Mouse1.58149591
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57240634
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55216543
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.52536174
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50481907
53* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49270791
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46745135
55CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.45177773
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.42984023
57* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.38640825
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37749652
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35785465
60KDM5A_27292631_Chip-Seq_BREAST_Human1.33194748
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31464646
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29567866
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24243127
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23790911
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.22493051
66PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22112996
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.21240548
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20949013
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20708168
70MYC_22102868_ChIP-Seq_BL_Human1.19844866
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17540954
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17328897
73* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11197279
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10854330
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.10411049
76MYC_18940864_ChIP-ChIP_HL60_Human1.07423486
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05573585
78SOX2_16153702_ChIP-ChIP_HESCs_Human1.04915983
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03980270
80KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99219619
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99113562
82TFEB_21752829_ChIP-Seq_HELA_Human0.98594998
83ELK1_22589737_ChIP-Seq_MCF10A_Human0.98281358
84BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97624578
85POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96894530
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96815926
87SPI1_23547873_ChIP-Seq_NB4_Human0.96746397
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93717504
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92746849
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91429604
91CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89927000
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89313793
93STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87342428
94EWS_26573619_Chip-Seq_HEK293_Human0.86606391
95VDR_21846776_ChIP-Seq_THP-1_Human0.84527841
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81834519
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81776315
98* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80773223
99TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78123459
100SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.77151445
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77060418
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76335695
103CHD1_26751641_Chip-Seq_LNCaP_Human0.75857567
104NANOG_21062744_ChIP-ChIP_HESCs_Human0.73728474
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.71934099
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.69508346
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.69238086
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68714657
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.68589356
110IRF1_19129219_ChIP-ChIP_H3396_Human0.68143727
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67964470
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.65236623
113FUS_26573619_Chip-Seq_HEK293_Human0.64972078

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.66320007
2MP0010094_abnormal_chromosome_stability4.93215958
3MP0004957_abnormal_blastocyst_morpholog4.39830573
4MP0003111_abnormal_nucleus_morphology4.24301247
5MP0003077_abnormal_cell_cycle4.06727481
6MP0008057_abnormal_DNA_replication3.94149646
7MP0008058_abnormal_DNA_repair3.82420763
8MP0008007_abnormal_cellular_replicative3.08681352
9MP0008932_abnormal_embryonic_tissue2.74614230
10MP0002396_abnormal_hematopoietic_system2.61210702
11MP0003123_paternal_imprinting2.34859027
12MP0008877_abnormal_DNA_methylation2.15421656
13MP0003786_premature_aging2.08458705
14MP0000350_abnormal_cell_proliferation2.06609644
15MP0009379_abnormal_foot_pigmentation2.01391470
16MP0001730_embryonic_growth_arrest1.99704292
17MP0000490_abnormal_crypts_of1.93390840
18MP0006292_abnormal_olfactory_placode1.75590690
19MP0003121_genomic_imprinting1.66702811
20MP0010030_abnormal_orbit_morphology1.66216186
21MP0004808_abnormal_hematopoietic_stem1.65476569
22MP0010307_abnormal_tumor_latency1.55001674
23MP0003567_abnormal_fetal_cardiomyocyte1.51933315
24MP0006035_abnormal_mitochondrial_morpho1.51518170
25MP0010352_gastrointestinal_tract_polyps1.49547131
26MP0001697_abnormal_embryo_size1.49154690
27MP0000313_abnormal_cell_death1.46153559
28MP0003315_abnormal_perineum_morphology1.45046235
29MP0002938_white_spotting1.43793374
30MP0005380_embryogenesis_phenotype1.41844861
31MP0001672_abnormal_embryogenesis/_devel1.41844861
32MP0002019_abnormal_tumor_incidence1.38981620
33MP0002080_prenatal_lethality1.38946533
34MP0003718_maternal_effect1.36900147
35MP0003763_abnormal_thymus_physiology1.36436943
36MP0009333_abnormal_splenocyte_physiolog1.35540875
37MP0003890_abnormal_embryonic-extraembry1.31127743
38MP0002210_abnormal_sex_determination1.27405513
39MP0006054_spinal_hemorrhage1.27386840
40MP0002085_abnormal_embryonic_tissue1.27224689
41MP0003984_embryonic_growth_retardation1.23660527
42MP0002697_abnormal_eye_size1.23574204
43MP0002398_abnormal_bone_marrow1.22243917
44MP0002088_abnormal_embryonic_growth/wei1.21340209
45MP0001346_abnormal_lacrimal_gland1.19090270
46MP0001293_anophthalmia1.14059410
47MP0002095_abnormal_skin_pigmentation1.13994651
48MP0000703_abnormal_thymus_morphology1.13866463
49MP0001529_abnormal_vocalization1.12217245
50MP0005174_abnormal_tail_pigmentation1.09505987
51MP0000537_abnormal_urethra_morphology1.08501737
52MP0001145_abnormal_male_reproductive1.06229006
53MP0002086_abnormal_extraembryonic_tissu1.05748333
54MP0002084_abnormal_developmental_patter1.04519509
55MP0000689_abnormal_spleen_morphology1.03941956
56MP0002722_abnormal_immune_system1.03615533
57MP0005397_hematopoietic_system_phenotyp1.03239859
58MP0001545_abnormal_hematopoietic_system1.03239859
59MP0004197_abnormal_fetal_growth/weight/1.01432228
60MP0001835_abnormal_antigen_presentation0.98428781
61MP0002429_abnormal_blood_cell0.96223561
62MP0009703_decreased_birth_body0.95074532
63MP0002160_abnormal_reproductive_system0.93136917
64MP0001119_abnormal_female_reproductive0.92328168
65MP0000653_abnormal_sex_gland0.91883884
66MP0001188_hyperpigmentation0.91560369
67MP0001929_abnormal_gametogenesis0.91283530
68MP0003941_abnormal_skin_development0.89913625
69MP0003186_abnormal_redox_activity0.89896909
70MP0002009_preneoplasia0.89501182
71MP0001853_heart_inflammation0.89307587
72MP0008789_abnormal_olfactory_epithelium0.88689992
73MP0002102_abnormal_ear_morphology0.88039013
74MP0003119_abnormal_digestive_system0.87667155
75MP0005075_abnormal_melanosome_morpholog0.84633263
76MP0002233_abnormal_nose_morphology0.83422942
77MP0000716_abnormal_immune_system0.82067293
78MP0000049_abnormal_middle_ear0.81824621
79MP0002877_abnormal_melanocyte_morpholog0.81569308
80MP0002092_abnormal_eye_morphology0.80570543
81MP0002132_abnormal_respiratory_system0.80453385
82MP0001661_extended_life_span0.80350129
83MP0005501_abnormal_skin_physiology0.78213544
84MP0000358_abnormal_cell_content/0.77297983
85MP0004147_increased_porphyrin_level0.77092809
86MP0009053_abnormal_anal_canal0.77091075
87MP0003698_abnormal_male_reproductive0.76794876
88MP0005389_reproductive_system_phenotype0.76056649
89MP0009672_abnormal_birth_weight0.75183469
90MP0003221_abnormal_cardiomyocyte_apopto0.75125755
91MP0003943_abnormal_hepatobiliary_system0.75088039
92MP0005076_abnormal_cell_differentiation0.74470184
93MP0000858_altered_metastatic_potential0.73492908
94MP0002796_impaired_skin_barrier0.73292580
95MP0002751_abnormal_autonomic_nervous0.73245544
96MP0006072_abnormal_retinal_apoptosis0.72631307
97MP0003861_abnormal_nervous_system0.72320439
98MP0004185_abnormal_adipocyte_glucose0.70834162
99MP0002111_abnormal_tail_morphology0.70512267
100MP0006036_abnormal_mitochondrial_physio0.69939916
101MP0000015_abnormal_ear_pigmentation0.69264237
102MP0001286_abnormal_eye_development0.67774786
103MP0002420_abnormal_adaptive_immunity0.67457670
104MP0001800_abnormal_humoral_immune0.67420145
105MP0002161_abnormal_fertility/fecundity0.67221563
106MP0003136_yellow_coat_color0.66263148
107MP0001819_abnormal_immune_cell0.65962239
108MP0003699_abnormal_female_reproductive0.64923345
109MP0005408_hypopigmentation0.62694767
110MP0000579_abnormal_nail_morphology0.62674382
111MP0001727_abnormal_embryo_implantation0.62631228
112MP0004133_heterotaxia0.62436098
113MP0009785_altered_susceptibility_to0.62278245
114MP0003937_abnormal_limbs/digits/tail_de0.62196033
115MP0005384_cellular_phenotype0.61790365
116MP0005671_abnormal_response_to0.61712305
117MP0002452_abnormal_antigen_presenting0.61017626
118MP0004233_abnormal_muscle_weight0.60561156
119MP0000428_abnormal_craniofacial_morphol0.60046881
120MP0009697_abnormal_copulation0.59336345
121MP0000647_abnormal_sebaceous_gland0.59003319
122MP0008995_early_reproductive_senescence0.58948288
123MP0000477_abnormal_intestine_morphology0.58770521
124MP0003755_abnormal_palate_morphology0.58673759
125MP0003806_abnormal_nucleotide_metabolis0.58614481
126MP0000465_gastrointestinal_hemorrhage0.58085463
127MP0000372_irregular_coat_pigmentation0.57898586
128MP0002075_abnormal_coat/hair_pigmentati0.57380473
129MP0003935_abnormal_craniofacial_develop0.55275433
130MP0005621_abnormal_cell_physiology0.54811183
131MP0001186_pigmentation_phenotype0.54526461
132MP0005394_taste/olfaction_phenotype0.53800557
133MP0005499_abnormal_olfactory_system0.53800557
134MP0005391_vision/eye_phenotype0.52515824

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.49306309
2Reticulocytopenia (HP:0001896)5.27857541
3Abnormality of cells of the erythroid lineage (HP:0012130)4.90631322
4Abnormal number of erythroid precursors (HP:0012131)4.75437109
5Chromsome breakage (HP:0040012)4.43675339
6Breast hypoplasia (HP:0003187)4.34107718
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33115440
8Colon cancer (HP:0003003)3.93962297
9Abnormality of the preputium (HP:0100587)3.63592348
10Oral leukoplakia (HP:0002745)3.61973507
11Patellar aplasia (HP:0006443)3.53958692
12Meckel diverticulum (HP:0002245)3.50239482
13Aplastic anemia (HP:0001915)3.44689213
14Abnormality of the ileum (HP:0001549)3.37176284
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.35846804
16Abnormality of chromosome stability (HP:0003220)3.32547209
17Aplasia/Hypoplasia of the patella (HP:0006498)3.30998033
18Pallor (HP:0000980)3.25718052
19Macrocytic anemia (HP:0001972)3.24644469
20Abnormality of the labia minora (HP:0012880)3.18983245
21Medulloblastoma (HP:0002885)3.02433371
22Degeneration of anterior horn cells (HP:0002398)2.95729421
23Abnormality of the anterior horn cell (HP:0006802)2.95729421
24Rough bone trabeculation (HP:0100670)2.93207737
2511 pairs of ribs (HP:0000878)2.85510071
26Volvulus (HP:0002580)2.84971329
27Duodenal stenosis (HP:0100867)2.82671863
28Small intestinal stenosis (HP:0012848)2.82671863
29Microvesicular hepatic steatosis (HP:0001414)2.80867035
30Myelodysplasia (HP:0002863)2.78685426
31Absent thumb (HP:0009777)2.78509773
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.70530187
33Selective tooth agenesis (HP:0001592)2.64816558
34Cortical dysplasia (HP:0002539)2.63301153
35Agnosia (HP:0010524)2.62921951
36Microretrognathia (HP:0000308)2.57487295
37Nephroblastoma (Wilms tumor) (HP:0002667)2.54564066
38Triphalangeal thumb (HP:0001199)2.53469449
39Bone marrow hypocellularity (HP:0005528)2.53341590
40Multiple enchondromatosis (HP:0005701)2.52479210
41Impulsivity (HP:0100710)2.50315702
42Thrombocytosis (HP:0001894)2.47550420
43Premature graying of hair (HP:0002216)2.46295603
44Abnormal lung lobation (HP:0002101)2.45440926
45Carpal bone hypoplasia (HP:0001498)2.40086782
46Cleft eyelid (HP:0000625)2.39646440
47Embryonal renal neoplasm (HP:0011794)2.39153206
48Abnormality of the duodenum (HP:0002246)2.31220375
49Abnormal number of incisors (HP:0011064)2.30266147
50Atresia of the external auditory canal (HP:0000413)2.29251795
51Neoplasm of the pancreas (HP:0002894)2.25378111
52Absent radius (HP:0003974)2.24688548
53Clubbing of toes (HP:0100760)2.23249734
54Abnormality of methionine metabolism (HP:0010901)2.23191662
55Abnormality of DNA repair (HP:0003254)2.22115008
56Abnormality of the carotid arteries (HP:0005344)2.21985778
57Tracheoesophageal fistula (HP:0002575)2.21277545
58Abnormality of glycolysis (HP:0004366)2.17765679
59Slender long bone (HP:0003100)2.16563072
60Type I transferrin isoform profile (HP:0003642)2.16420102
61Sloping forehead (HP:0000340)2.14424658
62Ependymoma (HP:0002888)2.13449722
63Rhabdomyosarcoma (HP:0002859)2.12170651
64Cellular immunodeficiency (HP:0005374)2.10363636
65Duplicated collecting system (HP:0000081)2.08961308
66Lymphoma (HP:0002665)2.08669801
67Aplasia involving forearm bones (HP:0009822)2.08503800
68Absent forearm bone (HP:0003953)2.08503800
69Acute necrotizing encephalopathy (HP:0006965)2.08466826
70Abnormal trabecular bone morphology (HP:0100671)2.08435050
71Choanal atresia (HP:0000453)2.08274722
72Proximal placement of thumb (HP:0009623)2.07439224
73Horseshoe kidney (HP:0000085)2.07216133
74Diastasis recti (HP:0001540)2.06485903
75Glioma (HP:0009733)2.04328794
76Acute encephalopathy (HP:0006846)2.04090391
77Optic nerve coloboma (HP:0000588)2.04074289
78Pancytopenia (HP:0001876)2.03187929
79Ectopic kidney (HP:0000086)2.02775568
80Abnormality of cochlea (HP:0000375)2.02290434
81Increased serum pyruvate (HP:0003542)2.01612374
82Abnormality of the heme biosynthetic pathway (HP:0010472)2.00287710
83Megaloblastic anemia (HP:0001889)1.99582430
84Lipid accumulation in hepatocytes (HP:0006561)1.98229063
85Embryonal neoplasm (HP:0002898)1.97265876
86Abnormal mitochondria in muscle tissue (HP:0008316)1.96088503
87Short thumb (HP:0009778)1.95404598
88Poikiloderma (HP:0001029)1.94086466
89Hypoplasia of the capital femoral epiphysis (HP:0003090)1.92573838
90Abnormality of the renal collecting system (HP:0004742)1.92375647
91Aplasia/Hypoplasia of the sternum (HP:0006714)1.88742095
92Arteriovenous malformation (HP:0100026)1.88222811
93Duplication of thumb phalanx (HP:0009942)1.87655280
94Deviation of the thumb (HP:0009603)1.87220221
95Exertional dyspnea (HP:0002875)1.86870722
96Increased CSF lactate (HP:0002490)1.84900763
97Progressive external ophthalmoplegia (HP:0000590)1.84666512
98Abnormality of reticulocytes (HP:0004312)1.84586438
99Increased hepatocellular lipid droplets (HP:0006565)1.82855618
100Trismus (HP:0000211)1.82107275
101High pitched voice (HP:0001620)1.81538776
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79668411
103Depressed nasal ridge (HP:0000457)1.79493875
104Neoplasm of the colon (HP:0100273)1.79157600
105Basal cell carcinoma (HP:0002671)1.78300251
106Progressive muscle weakness (HP:0003323)1.77620094
107IgM deficiency (HP:0002850)1.76037812
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75972605
109Cerebral edema (HP:0002181)1.74932726
110Abnormality of the fetal cardiovascular system (HP:0010948)1.74894108
111Abnormal umbilical cord blood vessels (HP:0011403)1.74894108
112Single umbilical artery (HP:0001195)1.74894108
113Overlapping toe (HP:0001845)1.74485609
114Facial cleft (HP:0002006)1.73783561
115Missing ribs (HP:0000921)1.72893429
116Cerebral hypomyelination (HP:0006808)1.72149157
117Supernumerary spleens (HP:0009799)1.72052888
118Squamous cell carcinoma (HP:0002860)1.71359157
119Decreased activity of mitochondrial respiratory chain (HP:0008972)1.71213511
120Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.71213511
121High anterior hairline (HP:0009890)1.70849026
122Abnormality of pyrimidine metabolism (HP:0004353)1.70423318
123Postnatal microcephaly (HP:0005484)1.69107869
124Prominent metopic ridge (HP:0005487)1.69003833
125Abnormality of the astrocytes (HP:0100707)1.67378401
126Astrocytoma (HP:0009592)1.67378401
127Increased serum lactate (HP:0002151)1.67373343
128Acute myeloid leukemia (HP:0004808)1.65801822
129Asplenia (HP:0001746)1.65026319
130Increased nuchal translucency (HP:0010880)1.64602576
131Hypoplasia of the pons (HP:0012110)1.64401113
132Hypoplastic pelvis (HP:0008839)1.63770734
133Ovarian neoplasm (HP:0100615)1.63433332
134Abnormality of the pons (HP:0007361)1.63426650
135Microglossia (HP:0000171)1.62557864
136Cafe-au-lait spot (HP:0000957)1.62401403
137Atrophy/Degeneration involving motor neurons (HP:0007373)1.62045545
138Abnormality of the umbilical cord (HP:0010881)1.60559256
139Abnormality of the septum pellucidum (HP:0007375)1.57759612
140Pancreatic islet-cell hyperplasia (HP:0004510)1.57668214

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.42363010
2WEE14.42128198
3BUB14.12960761
4STK163.37534099
5ACVR1B3.12724525
6VRK22.97394887
7SRPK12.93852700
8EIF2AK12.88971550
9MKNK12.49640999
10BRSK22.48657137
11NEK22.34113147
12NME22.32211136
13PLK42.30985995
14VRK12.26765228
15MKNK22.04115228
16TAF12.00835215
17TLK11.97581750
18EIF2AK31.91807949
19PLK11.89715685
20CDK71.89181918
21TTK1.88371436
22PASK1.78203223
23TSSK61.77711908
24ATR1.77696867
25TGFBR11.76844110
26AURKB1.71763594
27NEK11.67417738
28CCNB11.65442299
29DYRK31.61835920
30CDK81.58860304
31BRSK11.58631491
32RPS6KA41.49088140
33CHEK21.36053189
34PLK31.33952157
35PNCK1.33886255
36TRIM281.33712491
37TESK21.26829877
38CDK41.23228330
39AURKA1.19296665
40RPS6KB21.18962057
41ZAK1.16537672
42SMG11.15615319
43EIF2AK21.05039013
44NUAK11.03851891
45MAP3K81.02482357
46CHEK11.01583240
47STK40.91308357
48DYRK20.91272980
49PIM20.89732343
50IRAK40.83455776
51ALK0.83081913
52PDK20.78598603
53PIM10.77045427
54ATM0.76351480
55STK100.75428463
56CSNK2A10.74310557
57YES10.72946326
58CDK20.71664144
59BRAF0.71659385
60PAK40.70117087
61MAP4K10.69914944
62STK30.67502901
63CLK10.66755108
64PRKCI0.66733028
65CSNK2A20.66719840
66MELK0.66512738
67MAP2K30.66227200
68KDR0.63932614
69FLT30.61682021
70ERBB40.61223998
71BMPR1B0.60335180
72PBK0.59404778
73CDK60.58469127
74BRD40.56218013
75CDK10.55664660
76CDK120.53693587
77LRRK20.52016212
78WNK30.51514559
79RPS6KA50.50918616
80CDK30.49252554
81MST40.48126361
82KIT0.47228060
83MAP3K100.46896767
84TEC0.46770406
85STK38L0.46537063
86PAK10.45992290
87LATS10.44956544
88BTK0.44567572
89CSNK1G10.44454125
90TNIK0.43703454
91CSNK1E0.43554868
92CDK180.43167227
93ERBB30.41295404
94CDK150.40988669
95MAP2K60.40455404
96PLK20.39242722
97TYK20.39221802
98SCYL20.38292094
99EPHA20.38239164
100CDK140.36536166
101CSNK1G30.36424785
102NME10.36333880
103LYN0.35911632
104MST1R0.35862431
105BCKDK0.33999389
106BCR0.33549809
107FGFR10.33473128
108TESK10.32210941
109AKT20.31898480
110PRKG20.31481697
111IRAK30.30514157
112DAPK10.29038640
113ZAP700.27599576
114ILK0.26432978
115CSNK1A1L0.26296497
116NLK0.25693314
117CSF1R0.25333145
118TAOK20.24113048
119MAPKAPK50.23974593
120STK240.23246434
121TXK0.22188950
122CSNK1G20.22166699
123SYK0.21726609
124MAP3K110.21724836
125PRKDC0.21622481
126EEF2K0.20270148
127CDK11A0.19267966
128BLK0.18885279
129CDK190.17928789
130IKBKB0.17742477
131CDK90.17351868

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.82118857
2* Mismatch repair_Homo sapiens_hsa034304.87727928
3Ribosome_Homo sapiens_hsa030104.05689934
4Base excision repair_Homo sapiens_hsa034103.49228846
5Proteasome_Homo sapiens_hsa030503.43522507
6Homologous recombination_Homo sapiens_hsa034403.40232916
7Spliceosome_Homo sapiens_hsa030403.22427304
8* Nucleotide excision repair_Homo sapiens_hsa034203.16793566
9RNA polymerase_Homo sapiens_hsa030203.01935102
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.00610629
11Cell cycle_Homo sapiens_hsa041102.78896960
12Pyrimidine metabolism_Homo sapiens_hsa002402.63598202
13RNA transport_Homo sapiens_hsa030132.61418446
14Fanconi anemia pathway_Homo sapiens_hsa034602.52204913
15One carbon pool by folate_Homo sapiens_hsa006702.42224862
16Non-homologous end-joining_Homo sapiens_hsa034501.95553368
17RNA degradation_Homo sapiens_hsa030181.92720706
18Basal transcription factors_Homo sapiens_hsa030221.89335417
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82245818
20p53 signaling pathway_Homo sapiens_hsa041151.50359054
21mRNA surveillance pathway_Homo sapiens_hsa030151.38612403
22Purine metabolism_Homo sapiens_hsa002301.34243429
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32384892
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31664196
25Pyruvate metabolism_Homo sapiens_hsa006201.29594359
26Vitamin B6 metabolism_Homo sapiens_hsa007501.24258041
27Protein export_Homo sapiens_hsa030601.23294736
28Systemic lupus erythematosus_Homo sapiens_hsa053221.22256957
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20144935
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13797215
31Epstein-Barr virus infection_Homo sapiens_hsa051691.11274338
32Propanoate metabolism_Homo sapiens_hsa006401.02838035
33Herpes simplex infection_Homo sapiens_hsa051680.96549855
34Steroid biosynthesis_Homo sapiens_hsa001000.93578130
35Fatty acid elongation_Homo sapiens_hsa000620.90761137
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89212569
37Huntingtons disease_Homo sapiens_hsa050160.86305469
38Folate biosynthesis_Homo sapiens_hsa007900.85912173
39Parkinsons disease_Homo sapiens_hsa050120.84017845
40Viral carcinogenesis_Homo sapiens_hsa052030.83065098
41Antigen processing and presentation_Homo sapiens_hsa046120.78546009
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77800174
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77104910
44Oocyte meiosis_Homo sapiens_hsa041140.77060337
45Primary immunodeficiency_Homo sapiens_hsa053400.71805157
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68542026
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.66967158
48HTLV-I infection_Homo sapiens_hsa051660.66414452
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64532461
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62590918
51Oxidative phosphorylation_Homo sapiens_hsa001900.61939665
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59568617
53Pentose phosphate pathway_Homo sapiens_hsa000300.58304388
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56613894
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55231579
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53835552
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52647418
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50464700
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49849207
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47246651
61Selenocompound metabolism_Homo sapiens_hsa004500.46869372
62Glutathione metabolism_Homo sapiens_hsa004800.46746674
63Measles_Homo sapiens_hsa051620.46515725
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.45874284
65Legionellosis_Homo sapiens_hsa051340.45661666
66N-Glycan biosynthesis_Homo sapiens_hsa005100.44614147
67Lysine degradation_Homo sapiens_hsa003100.44157106
68Alcoholism_Homo sapiens_hsa050340.43368659
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.43267174
70Small cell lung cancer_Homo sapiens_hsa052220.42889608
71Thyroid cancer_Homo sapiens_hsa052160.42267534
72MicroRNAs in cancer_Homo sapiens_hsa052060.40600470
73Sulfur relay system_Homo sapiens_hsa041220.40446966
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.39123494
75Hepatitis B_Homo sapiens_hsa051610.36328120
76Biosynthesis of amino acids_Homo sapiens_hsa012300.35946001
77Apoptosis_Homo sapiens_hsa042100.35778053
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35731864
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34667877
80Hematopoietic cell lineage_Homo sapiens_hsa046400.32399297
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32229700
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.31345851
83Allograft rejection_Homo sapiens_hsa053300.31163668
84Shigellosis_Homo sapiens_hsa051310.30916899
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.29873612
86Colorectal cancer_Homo sapiens_hsa052100.29346604
87Fatty acid metabolism_Homo sapiens_hsa012120.28613544
88Alzheimers disease_Homo sapiens_hsa050100.26903277
89Basal cell carcinoma_Homo sapiens_hsa052170.23611654
90TGF-beta signaling pathway_Homo sapiens_hsa043500.23233700
91Metabolic pathways_Homo sapiens_hsa011000.23206073
92Viral myocarditis_Homo sapiens_hsa054160.22659293
93Influenza A_Homo sapiens_hsa051640.21865564
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21491504
95Arginine and proline metabolism_Homo sapiens_hsa003300.20269767
96Adherens junction_Homo sapiens_hsa045200.19283258
97Prostate cancer_Homo sapiens_hsa052150.18225830
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17638126
99Fructose and mannose metabolism_Homo sapiens_hsa000510.17289303
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17066412
101Asthma_Homo sapiens_hsa053100.16843645
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15324446
103Pathways in cancer_Homo sapiens_hsa052000.15008952
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14684443
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14677650
106Vitamin digestion and absorption_Homo sapiens_hsa049770.14339331
107Arachidonic acid metabolism_Homo sapiens_hsa005900.13812290
108Carbon metabolism_Homo sapiens_hsa012000.13608063
109Galactose metabolism_Homo sapiens_hsa000520.13157172
110Notch signaling pathway_Homo sapiens_hsa043300.12792763
111Leishmaniasis_Homo sapiens_hsa051400.12717093
112Bladder cancer_Homo sapiens_hsa052190.12452104
113Autoimmune thyroid disease_Homo sapiens_hsa053200.11668223
114Cardiac muscle contraction_Homo sapiens_hsa042600.09770561
115Melanoma_Homo sapiens_hsa052180.09653918
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09402655
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.09036168
118Chronic myeloid leukemia_Homo sapiens_hsa052200.08429091
119Hippo signaling pathway_Homo sapiens_hsa043900.08043854
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07769561
121Hedgehog signaling pathway_Homo sapiens_hsa043400.06852318
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06482763
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.06151465
124Wnt signaling pathway_Homo sapiens_hsa043100.05910089
125Regulation of autophagy_Homo sapiens_hsa041400.05892667
126beta-Alanine metabolism_Homo sapiens_hsa004100.01217993
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01115710
128Pancreatic cancer_Homo sapiens_hsa052120.01062547
129Peroxisome_Homo sapiens_hsa041460.00171610

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