RFESD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX biosynthetic process (GO:0006782)7.92808755
2protoporphyrinogen IX metabolic process (GO:0046501)7.87037479
3heme biosynthetic process (GO:0006783)6.80885051
4porphyrin-containing compound biosynthetic process (GO:0006779)5.81379368
5DNA deamination (GO:0045006)5.80762309
6heme metabolic process (GO:0042168)5.71990314
7ribosomal small subunit assembly (GO:0000028)5.49441953
8tetrapyrrole biosynthetic process (GO:0033014)5.43674095
9oxygen transport (GO:0015671)5.32819331
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.28816019
11CENP-A containing nucleosome assembly (GO:0034080)5.28111712
12gas transport (GO:0015669)5.14792157
13chromatin remodeling at centromere (GO:0031055)5.01775787
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.88358345
15ATP synthesis coupled proton transport (GO:0015986)4.88358345
16porphyrin-containing compound metabolic process (GO:0006778)4.84737556
17synapsis (GO:0007129)4.82689318
18viral transcription (GO:0019083)4.79582086
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.73303248
20cotranslational protein targeting to membrane (GO:0006613)4.67148173
21DNA replication checkpoint (GO:0000076)4.63487929
22protein targeting to ER (GO:0045047)4.62020592
23translational termination (GO:0006415)4.60442550
24protein localization to endoplasmic reticulum (GO:0070972)4.43584610
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40868784
26establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37323743
27histone exchange (GO:0043486)4.30752669
28protein complex biogenesis (GO:0070271)4.27099158
29respiratory chain complex IV assembly (GO:0008535)4.24716710
30respiratory electron transport chain (GO:0022904)4.18029105
31translational elongation (GO:0006414)4.16690985
32DNA replication-independent nucleosome organization (GO:0034724)4.14170694
33DNA replication-independent nucleosome assembly (GO:0006336)4.14170694
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.13556312
35mitochondrial respiratory chain complex I assembly (GO:0032981)4.13556312
36NADH dehydrogenase complex assembly (GO:0010257)4.13556312
37electron transport chain (GO:0022900)4.09593737
38ribosomal small subunit biogenesis (GO:0042274)4.09107617
39DNA strand elongation involved in DNA replication (GO:0006271)4.05443754
40iron-sulfur cluster assembly (GO:0016226)4.01323067
41metallo-sulfur cluster assembly (GO:0031163)4.01323067
42DNA strand elongation (GO:0022616)3.99527028
43telomere maintenance via recombination (GO:0000722)3.99193358
44centriole replication (GO:0007099)3.98462809
45regulation of mitochondrial translation (GO:0070129)3.94693706
46mitochondrial respiratory chain complex assembly (GO:0033108)3.93221308
47kinetochore organization (GO:0051383)3.92605625
48protein-cofactor linkage (GO:0018065)3.90916154
49regulation of centriole replication (GO:0046599)3.87083310
50cytochrome complex assembly (GO:0017004)3.78992244
512-deoxyribonucleotide biosynthetic process (GO:0009265)3.74751406
52deoxyribose phosphate biosynthetic process (GO:0046385)3.74751406
53meiotic chromosome segregation (GO:0045132)3.73151221
54chaperone-mediated protein transport (GO:0072321)3.70416382
55mitotic recombination (GO:0006312)3.69397561
56proteasome assembly (GO:0043248)3.69296130
57cellular protein complex disassembly (GO:0043624)3.66346495
58cullin deneddylation (GO:0010388)3.66288973
59erythrocyte maturation (GO:0043249)3.63946924
60viral life cycle (GO:0019058)3.63268789
61signal peptide processing (GO:0006465)3.60552587
62positive regulation of histone H3-K4 methylation (GO:0051571)3.58114182
63translation (GO:0006412)3.57971184
64erythrocyte development (GO:0048821)3.57817876
65mitotic sister chromatid segregation (GO:0000070)3.57772064
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55428828
67kinetochore assembly (GO:0051382)3.51192547
68protein deneddylation (GO:0000338)3.50006321
69DNA replication initiation (GO:0006270)3.49836340
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47549266
71rRNA modification (GO:0000154)3.46975716
72mitotic nuclear envelope disassembly (GO:0007077)3.43822159
73regulation of histone H3-K9 methylation (GO:0051570)3.43299623
74gonadal mesoderm development (GO:0007506)3.39601409
75rRNA methylation (GO:0031167)3.38868247
76oxidative phosphorylation (GO:0006119)3.37532143
77telomere maintenance via telomere lengthening (GO:0010833)3.36087833
78mitotic metaphase plate congression (GO:0007080)3.35956048
79nucleotide-excision repair, DNA gap filling (GO:0006297)3.34905665
80translational initiation (GO:0006413)3.34104321
81centriole assembly (GO:0098534)3.33944402
82DNA replication-dependent nucleosome assembly (GO:0006335)3.33800954
83DNA replication-dependent nucleosome organization (GO:0034723)3.33800954
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.32970518
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32734755
86regulation of cellular amino acid metabolic process (GO:0006521)3.32188317
87resolution of meiotic recombination intermediates (GO:0000712)3.32148443
88mitotic chromosome condensation (GO:0007076)3.31572690
89nuclear pore complex assembly (GO:0051292)3.31367159
90guanosine-containing compound biosynthetic process (GO:1901070)3.29371816
91GTP biosynthetic process (GO:0006183)3.28101591
92hemoglobin metabolic process (GO:0020027)3.27671313
93sister chromatid segregation (GO:0000819)3.27593669
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.27345831
95purine nucleobase biosynthetic process (GO:0009113)3.25776860
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25256575
97aerobic respiration (GO:0009060)3.24956131
98DNA synthesis involved in DNA repair (GO:0000731)3.22774317
99pigment biosynthetic process (GO:0046148)3.19319332
100nuclear envelope disassembly (GO:0051081)3.18626661
101membrane disassembly (GO:0030397)3.18626661
102protein targeting to mitochondrion (GO:0006626)3.16862863
103tetrapyrrole metabolic process (GO:0033013)3.16329244
104regulation of DNA endoreduplication (GO:0032875)3.16265182
105chromosome segregation (GO:0007059)3.15964157
106regulation of centrosome cycle (GO:0046605)3.15265425
107nuclear pore organization (GO:0006999)3.15181790
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.13015126
109chromosome organization involved in meiosis (GO:0070192)3.12494500
110mitotic sister chromatid cohesion (GO:0007064)3.12156428
111IMP biosynthetic process (GO:0006188)3.09434034
112regulation of oxidative phosphorylation (GO:0002082)3.09236918
113deoxyribonucleotide biosynthetic process (GO:0009263)3.09122447
114maturation of SSU-rRNA (GO:0030490)3.08785699
115negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08502662
116folic acid-containing compound biosynthetic process (GO:0009396)3.07726806
117regulation of histone H3-K4 methylation (GO:0051569)3.05341899
118DNA topological change (GO:0006265)3.04384481
119protein targeting to membrane (GO:0006612)3.04165603
120protein complex disassembly (GO:0043241)3.03972770
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03575578
122protein K6-linked ubiquitination (GO:0085020)3.03158763
123piRNA metabolic process (GO:0034587)3.00256494
124macromolecular complex disassembly (GO:0032984)2.99981279
125negative regulation of chromosome segregation (GO:0051985)2.99835059
126establishment of protein localization to mitochondrion (GO:0072655)2.99215245
127mitotic G2/M transition checkpoint (GO:0044818)2.99026310
128DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.98257344
129ribosomal large subunit biogenesis (GO:0042273)2.98098422
130metaphase plate congression (GO:0051310)2.97424819
131positive regulation of histone methylation (GO:0031062)2.97405255
132regulation of meiosis I (GO:0060631)2.96787046
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.96530824
134negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96530824
135negative regulation of mitotic sister chromatid segregation (GO:0033048)2.96530824
136negative regulation of mitotic sister chromatid separation (GO:2000816)2.96530824
137negative regulation of sister chromatid segregation (GO:0033046)2.96530824
138negative regulation of norepinephrine secretion (GO:0010700)2.94822510
139chromatin assembly or disassembly (GO:0006333)2.93971745
140establishment of protein localization to mitochondrial membrane (GO:0090151)2.93010310
141purine-containing compound salvage (GO:0043101)2.92877871
142signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.92820671
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.92820671
144somatic diversification of immune receptors via somatic mutation (GO:0002566)2.91771518
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.91771518
146signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91650390
147signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91650390
148signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91650390
149dopamine transport (GO:0015872)2.91384865
150protein localization to chromosome, centromeric region (GO:0071459)2.90722992
151DNA catabolic process, exonucleolytic (GO:0000738)2.90665192
152mismatch repair (GO:0006298)2.90368320
153mitotic spindle assembly checkpoint (GO:0007094)2.88850112
154protein K11-linked ubiquitination (GO:0070979)2.87981234
155positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87741569
156pigment metabolic process (GO:0042440)2.87257461
157protein localization to kinetochore (GO:0034501)2.86474567
158mitotic spindle checkpoint (GO:0071174)2.84073522
159spindle assembly checkpoint (GO:0071173)2.84052411
160cellular component biogenesis (GO:0044085)2.83289630
161purine nucleoside triphosphate biosynthetic process (GO:0009145)2.82819371
162DNA double-strand break processing (GO:0000729)2.81755369
163protein localization to mitochondrion (GO:0070585)2.80331227
164telomere maintenance via semi-conservative replication (GO:0032201)2.78537417
165UTP biosynthetic process (GO:0006228)2.77735062
166purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.77429859
167signal transduction involved in DNA damage checkpoint (GO:0072422)2.76819746
168signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76819746
169regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74315802
170nucleoside diphosphate catabolic process (GO:0009134)2.74269375
171pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73995941
172negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71180049
173negative regulation of ligase activity (GO:0051352)2.71180049
174signal transduction involved in cell cycle checkpoint (GO:0072395)2.71122962
175cellular respiration (GO:0045333)2.69247949
176nuclear-transcribed mRNA catabolic process (GO:0000956)2.69161948

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.60781539
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.43111413
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.26910264
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.87667714
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.85081269
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.46417875
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.40530854
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.34686502
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.28834092
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.07071493
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03287435
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01919970
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.96860817
14VDR_23849224_ChIP-Seq_CD4+_Human2.80123869
15GATA1_22025678_ChIP-Seq_K562_Human2.76361300
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.70603773
17* SRF_21415370_ChIP-Seq_HL-1_Mouse2.65698615
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57168208
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55487929
20E2F7_22180533_ChIP-Seq_HELA_Human2.55068435
21FOXP3_21729870_ChIP-Seq_TREG_Human2.53101436
22* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.43445384
23FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.38947152
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.32718961
25DCP1A_22483619_ChIP-Seq_HELA_Human2.31712418
26ELK1_19687146_ChIP-ChIP_HELA_Human2.20185352
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.18283950
28AR_21909140_ChIP-Seq_LNCAP_Human2.18263731
29MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14635975
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.12701060
31TTF2_22483619_ChIP-Seq_HELA_Human2.06465584
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05989347
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.04294585
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04140108
35ERG_20887958_ChIP-Seq_HPC-7_Mouse2.01086795
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.99699813
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.96247115
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92341558
39XRN2_22483619_ChIP-Seq_HELA_Human1.89907474
40* GABP_19822575_ChIP-Seq_HepG2_Human1.88758894
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.79001493
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.75242775
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72585484
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.71083736
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.69500526
46VDR_22108803_ChIP-Seq_LS180_Human1.67889682
47CIITA_25753668_ChIP-Seq_RAJI_Human1.65300189
48* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.65109439
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62182833
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52573731
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48276558
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47125366
53EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46339337
54KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.45168415
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42028649
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.41927601
57E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41751240
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40846977
59IRF1_19129219_ChIP-ChIP_H3396_Human1.40031528
60* NOTCH1_21737748_ChIP-Seq_TLL_Human1.39430540
61* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37984726
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33981849
63MYC_18940864_ChIP-ChIP_HL60_Human1.32702610
64IGF1R_20145208_ChIP-Seq_DFB_Human1.30795106
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.29242103
66PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28860690
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.27915109
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26786359
69* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24967909
70GATA2_19941826_ChIP-Seq_K562_Human1.24634098
71KDM5A_27292631_Chip-Seq_BREAST_Human1.24407654
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.23177103
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.22643482
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21807075
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21251711
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17956524
77CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14709696
78E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13832463
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12055060
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09136725
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07988004
82SCL_19346495_ChIP-Seq_HPC-7_Human1.05824306
83CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05586817
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04635186
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02905219
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02149345
87FLI1_27457419_Chip-Seq_LIVER_Mouse1.01129849
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00909980
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.00909232
90* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00796099
91SALL4_22934838_ChIP-ChIP_CD34+_Human0.98571874
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98207740
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98133348
94NCOR1_26117541_ChIP-Seq_K562_Human0.97329372
95* TFEB_21752829_ChIP-Seq_HELA_Human0.97111890
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94948816
97TP53_22573176_ChIP-Seq_HFKS_Human0.94629621
98ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93547251
99EGR1_19374776_ChIP-ChIP_THP-1_Human0.93289224
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92040828
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91495193
102GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90493356
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89881582
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89570538
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.88752592
106CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88623392
107SPI1_23547873_ChIP-Seq_NB4_Human0.88590137
108E2F1_21310950_ChIP-Seq_MCF-7_Human0.87945293
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.87506303
110GATA1_19941826_ChIP-Seq_K562_Human0.86916078
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86249898
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.85704314
113NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85255394
114* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83518643
115EWS_26573619_Chip-Seq_HEK293_Human0.83074688
116* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80477854
117PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80347014
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.80053130
119SALL1_21062744_ChIP-ChIP_HESCs_Human0.75073446
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73294839
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71093415
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70742273
123SOX2_16153702_ChIP-ChIP_HESCs_Human0.70132932
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.66727598
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.66715343

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level7.80661420
2MP0003656_abnormal_erythrocyte_physiolo5.86183914
3MP0009379_abnormal_foot_pigmentation4.47599605
4MP0005083_abnormal_biliary_tract3.09229639
5MP0003806_abnormal_nucleotide_metabolis2.99455866
6MP0008995_early_reproductive_senescence2.72583229
7MP0003718_maternal_effect2.62456594
8MP0006036_abnormal_mitochondrial_physio2.59328689
9MP0002638_abnormal_pupillary_reflex2.31475648
10MP0005636_abnormal_mineral_homeostasis2.13670846
11MP0008877_abnormal_DNA_methylation2.10457238
12MP0000372_irregular_coat_pigmentation2.06428934
13MP0008932_abnormal_embryonic_tissue1.92950913
14MP0001764_abnormal_homeostasis1.92536769
15MP0003693_abnormal_embryo_hatching1.89478447
16MP0001188_hyperpigmentation1.79375336
17MP0008058_abnormal_DNA_repair1.79237744
18MP0008057_abnormal_DNA_replication1.78705986
19MP0010386_abnormal_urinary_bladder1.73296889
20MP0003186_abnormal_redox_activity1.72324777
21MP0001986_abnormal_taste_sensitivity1.69647209
22MP0005379_endocrine/exocrine_gland_phen1.68731006
23MP0005671_abnormal_response_to1.68340065
24MP0004145_abnormal_muscle_electrophysio1.65599925
25MP0002876_abnormal_thyroid_physiology1.59226079
26MP0002210_abnormal_sex_determination1.56254762
27MP0006276_abnormal_autonomic_nervous1.55643358
28MP0001529_abnormal_vocalization1.54315637
29MP0003890_abnormal_embryonic-extraembry1.50482033
30MP0001929_abnormal_gametogenesis1.50125059
31MP0006054_spinal_hemorrhage1.49700323
32MP0004957_abnormal_blastocyst_morpholog1.49673656
33MP0006035_abnormal_mitochondrial_morpho1.48873248
34MP0001835_abnormal_antigen_presentation1.48334487
35MP0009697_abnormal_copulation1.46967735
36MP0006292_abnormal_olfactory_placode1.46713154
37MP0009785_altered_susceptibility_to1.43351614
38MP0001697_abnormal_embryo_size1.39137369
39MP0005171_absent_coat_pigmentation1.38449028
40MP0001730_embryonic_growth_arrest1.38004978
41MP0005397_hematopoietic_system_phenotyp1.36809966
42MP0001545_abnormal_hematopoietic_system1.36809966
43MP0002693_abnormal_pancreas_physiology1.35779445
44MP0009333_abnormal_splenocyte_physiolog1.33530845
45MP0000350_abnormal_cell_proliferation1.30637400
46MP0010307_abnormal_tumor_latency1.29681160
47MP0010094_abnormal_chromosome_stability1.29359888
48MP0002160_abnormal_reproductive_system1.27600227
49MP0002139_abnormal_hepatobiliary_system1.23896290
50MP0002396_abnormal_hematopoietic_system1.21716653
51MP0000653_abnormal_sex_gland1.21654778
52MP0002398_abnormal_bone_marrow1.21635776
53MP0005389_reproductive_system_phenotype1.21092820
54MP0005645_abnormal_hypothalamus_physiol1.20088983
55MP0001145_abnormal_male_reproductive1.19774503
56MP0002735_abnormal_chemical_nociception1.19648339
57MP0000685_abnormal_immune_system1.18892646
58MP0005084_abnormal_gallbladder_morpholo1.18635618
59MP0002837_dystrophic_cardiac_calcinosis1.17185705
60MP0004043_abnormal_pH_regulation1.15188967
61MP0001348_abnormal_lacrimal_gland1.14145282
62MP0003786_premature_aging1.13828388
63MP0003724_increased_susceptibility_to1.13562265
64MP0002148_abnormal_hypersensitivity_rea1.12215506
65MP0003698_abnormal_male_reproductive1.11541217
66MP0005380_embryogenesis_phenotype1.10462116
67MP0001672_abnormal_embryogenesis/_devel1.10462116
68MP0003111_abnormal_nucleus_morphology1.07651717
69MP0005075_abnormal_melanosome_morpholog1.07424976
70MP0002080_prenatal_lethality1.06029508
71MP0003763_abnormal_thymus_physiology1.05126647
72MP0001905_abnormal_dopamine_level1.05078028
73MP0008872_abnormal_physiological_respon1.04379155
74MP0004215_abnormal_myocardial_fiber1.03901872
75MP0001944_abnormal_pancreas_morphology1.03680134
76MP0005464_abnormal_platelet_physiology1.03284856
77MP0002877_abnormal_melanocyte_morpholog1.02361126
78MP0002722_abnormal_immune_system0.99994334
79MP0000689_abnormal_spleen_morphology0.99835062
80MP0003984_embryonic_growth_retardation0.97644908
81MP0003950_abnormal_plasma_membrane0.96284845
82MP0008775_abnormal_heart_ventricle0.94729436
83MP0002088_abnormal_embryonic_growth/wei0.94459016
84MP0002429_abnormal_blood_cell0.94084924
85MP0003195_calcinosis0.92741867
86MP0001661_extended_life_span0.92717909
87MP0002084_abnormal_developmental_patter0.92500278
88MP0002095_abnormal_skin_pigmentation0.91645326
89MP0002163_abnormal_gland_morphology0.91293057
90MP0003880_abnormal_central_pattern0.91208032
91MP0008260_abnormal_autophagy0.90401815
92MP0008469_abnormal_protein_level0.89137702
93MP0008007_abnormal_cellular_replicative0.88240013
94MP0005394_taste/olfaction_phenotype0.88075836
95MP0005499_abnormal_olfactory_system0.88075836
96MP0000015_abnormal_ear_pigmentation0.87940073
97MP0001119_abnormal_female_reproductive0.87029079
98MP0003699_abnormal_female_reproductive0.86429553
99MP0005410_abnormal_fertilization0.86110706
100MP0002019_abnormal_tumor_incidence0.83649462
101MP0005025_abnormal_response_to0.83623182
102MP0005584_abnormal_enzyme/coenzyme_acti0.81010999
103MP0006072_abnormal_retinal_apoptosis0.79412940
104MP0003077_abnormal_cell_cycle0.79124831
105MP0002132_abnormal_respiratory_system0.78755283
106MP0005174_abnormal_tail_pigmentation0.78379556
107MP0001919_abnormal_reproductive_system0.77976961
108MP0001984_abnormal_olfaction0.77934346
109MP0002078_abnormal_glucose_homeostasis0.77873648
110MP0000358_abnormal_cell_content/0.77585905
111MP0000313_abnormal_cell_death0.76456822
112MP0005220_abnormal_exocrine_pancreas0.76290212
113MP0002161_abnormal_fertility/fecundity0.75844691
114MP0000013_abnormal_adipose_tissue0.75343129
115MP0002086_abnormal_extraembryonic_tissu0.74255536
116MP0000749_muscle_degeneration0.74168832
117MP0004782_abnormal_surfactant_physiolog0.73899057
118MP0005266_abnormal_metabolism0.73327844
119MP0000716_abnormal_immune_system0.72962596
120MP0005376_homeostasis/metabolism_phenot0.72383318
121MP0003221_abnormal_cardiomyocyte_apopto0.71748948
122MP0009765_abnormal_xenobiotic_induced0.70606688
123MP0002723_abnormal_immune_serum0.69475643
124MP0005000_abnormal_immune_tolerance0.69392152
125MP0005646_abnormal_pituitary_gland0.69067367
126MP0002085_abnormal_embryonic_tissue0.68956371
127MP0005310_abnormal_salivary_gland0.68897178
128MP0002420_abnormal_adaptive_immunity0.68828699
129MP0002734_abnormal_mechanical_nocicepti0.68381808
130MP0000703_abnormal_thymus_morphology0.68376216
131MP0001800_abnormal_humoral_immune0.67721069
132MP0001819_abnormal_immune_cell0.66968187
133MP0002166_altered_tumor_susceptibility0.65431004
134MP0000490_abnormal_crypts_of0.64941969
135MP0008789_abnormal_olfactory_epithelium0.64920968
136MP0003122_maternal_imprinting0.64621322
137MP0005395_other_phenotype0.63603305
138MP0002102_abnormal_ear_morphology0.61110248
139MP0003567_abnormal_fetal_cardiomyocyte0.59917788
140MP0004808_abnormal_hematopoietic_stem0.58868820
141MP0002938_white_spotting0.57677088
142MP0000609_abnormal_liver_physiology0.55203712
143MP0000598_abnormal_liver_morphology0.52968700
144MP0010030_abnormal_orbit_morphology0.52758108
145MP0005384_cellular_phenotype0.51973106
146MP0002009_preneoplasia0.50868503
147MP0001873_stomach_inflammation0.49523661
148MP0005647_abnormal_sex_gland0.49431790
149MP0009931_abnormal_skin_appearance0.48066137
150MP0001881_abnormal_mammary_gland0.46705027
151MP0005330_cardiomyopathy0.45907204
152MP0008004_abnormal_stomach_pH0.45641596
153MP0009703_decreased_birth_body0.45193160

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the heme biosynthetic pathway (HP:0010472)8.77824563
2Abnormality of cells of the erythroid lineage (HP:0012130)5.11018712
3Abnormal number of erythroid precursors (HP:0012131)5.06795991
4Acute necrotizing encephalopathy (HP:0006965)4.82222241
5Mitochondrial inheritance (HP:0001427)4.61320070
6Hepatocellular necrosis (HP:0001404)4.55099374
7Abnormal mitochondria in muscle tissue (HP:0008316)4.47540149
8Acute encephalopathy (HP:0006846)4.40431584
9Increased CSF lactate (HP:0002490)4.35820543
10Hepatic necrosis (HP:0002605)4.27704935
11Progressive macrocephaly (HP:0004481)4.10194535
12Chromsome breakage (HP:0040012)4.08185837
13Increased hepatocellular lipid droplets (HP:0006565)3.99268598
14Lipid accumulation in hepatocytes (HP:0006561)3.97250298
15Abnormal hemoglobin (HP:0011902)3.93091074
16Poikilocytosis (HP:0004447)3.91723341
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.74480535
18Abnormal hair whorl (HP:0010721)3.49009732
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.48865401
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.48865401
21Respiratory difficulties (HP:0002880)3.43202171
223-Methylglutaconic aciduria (HP:0003535)3.37724515
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34942239
24Increased serum lactate (HP:0002151)3.28697236
25Acanthocytosis (HP:0001927)3.26313907
26Renal Fanconi syndrome (HP:0001994)3.20879736
27Hypothermia (HP:0002045)3.19907027
28Pallor (HP:0000980)3.16190321
29Hyperbilirubinemia (HP:0002904)3.13144989
30Polycythemia (HP:0001901)3.10268655
31Lactic acidosis (HP:0003128)3.03555823
32Abnormality of chromosome stability (HP:0003220)3.02210257
33Aplastic anemia (HP:0001915)3.01003411
34Ileus (HP:0002595)2.97267684
35Increased intramyocellular lipid droplets (HP:0012240)2.94203630
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87651113
37Cerebral edema (HP:0002181)2.86463306
38Microvesicular hepatic steatosis (HP:0001414)2.86126498
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.81574477
40Macrocytic anemia (HP:0001972)2.75360373
41Exertional dyspnea (HP:0002875)2.74412132
42Increased muscle lipid content (HP:0009058)2.72994746
43Reticulocytopenia (HP:0001896)2.66862527
44Optic disc pallor (HP:0000543)2.61010957
45Duodenal stenosis (HP:0100867)2.60128379
46Small intestinal stenosis (HP:0012848)2.60128379
47Abnormality of the preputium (HP:0100587)2.59289747
48Birth length less than 3rd percentile (HP:0003561)2.58795905
49Abnormality of reticulocytes (HP:0004312)2.55296298
50Respiratory failure (HP:0002878)2.54670189
51Exercise intolerance (HP:0003546)2.54477206
52Meckel diverticulum (HP:0002245)2.51381620
53Homocystinuria (HP:0002156)2.50546020
54Abnormality of homocysteine metabolism (HP:0010919)2.50546020
55Reticulocytosis (HP:0001923)2.48790294
56Cholelithiasis (HP:0001081)2.45773655
57Paralysis (HP:0003470)2.43117527
58Abnormal gallbladder morphology (HP:0012437)2.42580727
59Abnormality of the ileum (HP:0001549)2.34866319
60Volvulus (HP:0002580)2.34221267
61Increased serum pyruvate (HP:0003542)2.29784434
62Short middle phalanx of the 5th finger (HP:0004220)2.26230878
63Myelodysplasia (HP:0002863)2.22438425
64Hypochromic microcytic anemia (HP:0004840)2.21869375
65Generalized aminoaciduria (HP:0002909)2.21745602
66Cutaneous photosensitivity (HP:0000992)2.19643652
67Hyperphosphaturia (HP:0003109)2.18890735
68Increased serum ferritin (HP:0003281)2.16258004
69Petechiae (HP:0000967)2.15276252
70Diaphragmatic weakness (HP:0009113)2.14123528
71CNS demyelination (HP:0007305)2.13122052
72Abnormality of the anterior horn cell (HP:0006802)2.11705507
73Degeneration of anterior horn cells (HP:0002398)2.11705507
74Abnormality of the duodenum (HP:0002246)2.10795731
75Abnormality of urine glucose concentration (HP:0011016)2.10451805
76Glycosuria (HP:0003076)2.10451805
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07670596
78Abnormality of alanine metabolism (HP:0010916)2.07670596
79Hyperalaninemia (HP:0003348)2.07670596
80Abnormality of methionine metabolism (HP:0010901)2.07156077
81Abnormality of renal resorption (HP:0011038)2.07151366
82Methylmalonic acidemia (HP:0002912)2.06604873
83Cerebral palsy (HP:0100021)2.05659068
84Duplicated collecting system (HP:0000081)2.04717158
85Leukodystrophy (HP:0002415)2.04046836
86Abnormality of glycolysis (HP:0004366)2.01508488
87Nausea (HP:0002018)2.00611213
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.00083831
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95860974
90Microcytic anemia (HP:0001935)1.94629445
91Cholecystitis (HP:0001082)1.93343429
92Abnormal gallbladder physiology (HP:0012438)1.93343429
93Type I transferrin isoform profile (HP:0003642)1.91694067
94Abnormality of iron homeostasis (HP:0011031)1.89503811
95Gliosis (HP:0002171)1.88467391
96Renal cortical cysts (HP:0000803)1.88317127
9711 pairs of ribs (HP:0000878)1.88083419
98Absent thumb (HP:0009777)1.86954861
99Abnormality of the renal collecting system (HP:0004742)1.86949214
100Acute hepatic failure (HP:0006554)1.86766770
101Hypoplasia of the thymus (HP:0000778)1.85207028
102Long clavicles (HP:0000890)1.84936086
103Truncus arteriosus (HP:0001660)1.84752018
104Delayed CNS myelination (HP:0002188)1.84672491
105Pancytopenia (HP:0001876)1.83810593
106Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82052321
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.81556187
108Abnormal protein N-linked glycosylation (HP:0012347)1.81556187
109Abnormal protein glycosylation (HP:0012346)1.81556187
110Abnormal glycosylation (HP:0012345)1.81556187
111Abnormal lung lobation (HP:0002101)1.81135007
112Emotional lability (HP:0000712)1.80894333
113Abnormality of the labia minora (HP:0012880)1.80281421
114Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79642732
115Abnormal pupillary function (HP:0007686)1.79329013
116Methylmalonic aciduria (HP:0012120)1.77897692
117Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77895482
118Neuroendocrine neoplasm (HP:0100634)1.76345279
119Reduced antithrombin III activity (HP:0001976)1.75989319
120Neoplasm of the colon (HP:0100273)1.75878754
121Dicarboxylic aciduria (HP:0003215)1.72761548
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72761548
123Spinal muscular atrophy (HP:0007269)1.72707011
124Abnormality of the carotid arteries (HP:0005344)1.72034805
125Abnormality of transition element cation homeostasis (HP:0011030)1.71751850
126Lethargy (HP:0001254)1.71478949
127Abnormality of lateral ventricle (HP:0030047)1.70754767
128Global brain atrophy (HP:0002283)1.70671664
129Sloping forehead (HP:0000340)1.70670692
130Small hand (HP:0200055)1.70559009
131IgM deficiency (HP:0002850)1.69906518
132Prolonged bleeding time (HP:0003010)1.68016369
133Delayed myelination (HP:0012448)1.67851433
134Abnormal spermatogenesis (HP:0008669)1.67567966
135Vomiting (HP:0002013)1.67207094
136Esophageal neoplasm (HP:0100751)1.66830388
137Neoplasm of head and neck (HP:0012288)1.66830388
138Renal tubular dysfunction (HP:0000124)1.66753564
139Abnormality of sulfur amino acid metabolism (HP:0004339)1.66458887
140Abnormality of the gallbladder (HP:0005264)1.66027838
141Premature ovarian failure (HP:0008209)1.64831480
142Clubbing of toes (HP:0100760)1.64744541
143Triphalangeal thumb (HP:0001199)1.63181548
144Pancreatic islet-cell hyperplasia (HP:0004510)1.62868369

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK13.67061248
2VRK13.64377147
3STK163.53990913
4NME23.52098097
5MAP3K123.46118219
6TTK3.17046192
7PIM22.88315502
8ACVR1B2.83375749
9NEK12.72218992
10PBK2.65252670
11TLK12.26328365
12NME12.18402427
13ARAF2.15291758
14ZAK2.03712444
15PIK3CG1.93031417
16SRPK11.90407029
17DYRK31.89155435
18BMPR1B1.87667104
19BRAF1.87031409
20VRK21.84795584
21CLK11.75305735
22RAF11.67950238
23MAP2K71.67486405
24TRIM281.66506133
25NUAK11.66207378
26PLK11.64289989
27TNIK1.53196375
28PASK1.44126126
29BUB11.42655306
30EIF2AK31.41258837
31FLT31.41242339
32TEC1.37543089
33CHEK21.37459317
34CDK191.36541324
35IKBKE1.36292427
36MAP4K21.32110695
37PINK11.30883613
38MYLK1.28252748
39STK41.24800315
40CDK81.24422988
41BRSK21.21176976
42ERBB31.18804328
43ADRBK21.15390673
44KSR11.15378320
45TAOK31.14354212
46BMX1.12259237
47DAPK11.12140520
48SCYL21.10648702
49PDK21.03949123
50TXK0.99495844
51WEE10.98931066
52IRAK30.96245566
53KDR0.95744606
54TRPM70.94179695
55BCKDK0.92457966
56MUSK0.91335291
57ATM0.91291755
58IRAK40.90955588
59GRK50.89359243
60STK30.88653954
61CAMKK20.87732287
62SYK0.86306273
63MAP3K80.85728434
64KSR20.84326550
65CCNB10.84142269
66BTK0.81678314
67CHEK10.81265551
68HIPK20.80876810
69PLK30.80336283
70BMPR20.79722252
71MAPKAPK50.79350205
72MKNK10.77637491
73BRSK10.76109657
74MKNK20.75725640
75KIT0.75504545
76TSSK60.74485798
77PIM10.73231981
78CASK0.72110833
79MAPKAPK30.70850548
80TAF10.68499840
81MARK30.68497349
82MST40.67755620
83MAPK150.65083806
84MAP3K110.64209855
85CDC70.64143371
86MAPK110.62628318
87PLK20.62192862
88MAP3K90.61959053
89SGK20.61941442
90WNK40.61689316
91CDK70.58415292
92ZAP700.56762902
93TESK10.56585983
94CSNK2A10.56149294
95PNCK0.54349672
96AURKA0.54275468
97MAPK130.54146727
98CDK10.53397098
99CAMK2B0.52228774
100ABL20.52042821
101RPS6KA50.51617717
102CDK20.51513470
103CAMK2G0.50844841
104AURKB0.49591737
105TYK20.49406184
106OBSCN0.49334787
107LYN0.48892664
108MATK0.48039268
109RIPK40.47589137
110GRK70.46639762
111RPS6KC10.46038927
112RPS6KL10.46038927
113ATR0.45646376
114CSNK2A20.45426603
115NEK20.43991477
116RPS6KB20.43972121
117TAOK20.43520362
118CDK40.43504216
119RPS6KA60.42150188
120EIF2AK20.41803551
121DYRK1A0.40463236
122MELK0.39461428
123CAMK10.39236716
124MAP2K30.39185164
125INSRR0.38862843
126PDK30.38746184
127PDK40.38746184
128TGFBR10.38088721
129WNK10.37883952
130BRD40.37724626
131RPS6KB10.37683622
132PLK40.37672980
133IKBKB0.36778775
134CAMK40.35944705
135MAP3K50.35095772
136LCK0.34722001
137PTK2B0.34522201
138ERBB40.33669892
139CAMK2D0.33508567
140RPS6KA20.33011873
141MAP2K60.32896566
142AKT30.32830174
143MAP2K10.32433457
144NTRK30.32215234
145JAK20.32031325
146RPS6KA40.31549482
147PAK10.28628629
148STK100.27359379
149PRKDC0.27343071
150DAPK30.26219742
151CAMK1G0.24839558
152NEK60.24567043
153ILK0.24334581

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.72961514
2Oxidative phosphorylation_Homo sapiens_hsa001903.99544956
3Proteasome_Homo sapiens_hsa030503.98482277
4Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008603.97548884
5Protein export_Homo sapiens_hsa030603.91165083
6Parkinsons disease_Homo sapiens_hsa050123.73561351
7Huntingtons disease_Homo sapiens_hsa050162.69912021
8DNA replication_Homo sapiens_hsa030302.63542757
9Alzheimers disease_Homo sapiens_hsa050102.54668040
10RNA polymerase_Homo sapiens_hsa030202.32079562
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.28977925
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.27516609
13Pyrimidine metabolism_Homo sapiens_hsa002401.91618689
14Mismatch repair_Homo sapiens_hsa034301.88047412
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87637874
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.86332922
17Spliceosome_Homo sapiens_hsa030401.84867557
18Homologous recombination_Homo sapiens_hsa034401.76029078
19Nucleotide excision repair_Homo sapiens_hsa034201.60575084
20RNA degradation_Homo sapiens_hsa030181.58109610
21Non-homologous end-joining_Homo sapiens_hsa034501.50344015
22Oocyte meiosis_Homo sapiens_hsa041141.48987473
23Base excision repair_Homo sapiens_hsa034101.48763710
24SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36970344
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36653713
26Sulfur relay system_Homo sapiens_hsa041221.36418875
27Folate biosynthesis_Homo sapiens_hsa007901.35881576
28Nitrogen metabolism_Homo sapiens_hsa009101.34606047
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31548790
30Purine metabolism_Homo sapiens_hsa002301.24282908
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24040942
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21973509
33Basal transcription factors_Homo sapiens_hsa030221.21612084
34Pyruvate metabolism_Homo sapiens_hsa006201.19889338
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14976330
36Cardiac muscle contraction_Homo sapiens_hsa042601.11698897
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10582801
38Sulfur metabolism_Homo sapiens_hsa009201.08316862
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04392359
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03105369
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00848994
42One carbon pool by folate_Homo sapiens_hsa006701.00775551
43RNA transport_Homo sapiens_hsa030130.98736448
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97919180
45Glutathione metabolism_Homo sapiens_hsa004800.91279291
46N-Glycan biosynthesis_Homo sapiens_hsa005100.86132863
47Metabolic pathways_Homo sapiens_hsa011000.81276387
48mRNA surveillance pathway_Homo sapiens_hsa030150.78704651
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.77402146
50Primary immunodeficiency_Homo sapiens_hsa053400.75150450
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74782217
52Regulation of autophagy_Homo sapiens_hsa041400.74462408
53Collecting duct acid secretion_Homo sapiens_hsa049660.69098225
54Fatty acid metabolism_Homo sapiens_hsa012120.68565636
55Fanconi anemia pathway_Homo sapiens_hsa034600.67761558
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67190836
57Systemic lupus erythematosus_Homo sapiens_hsa053220.64043385
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63749160
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63328646
60Hematopoietic cell lineage_Homo sapiens_hsa046400.62883367
61Cell cycle_Homo sapiens_hsa041100.62683602
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59737567
63Pentose phosphate pathway_Homo sapiens_hsa000300.58718496
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.55839182
65Steroid biosynthesis_Homo sapiens_hsa001000.55307214
66Arachidonic acid metabolism_Homo sapiens_hsa005900.54306612
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53901457
68Peroxisome_Homo sapiens_hsa041460.53487471
69Vitamin B6 metabolism_Homo sapiens_hsa007500.51763360
70Alcoholism_Homo sapiens_hsa050340.49583965
71Selenocompound metabolism_Homo sapiens_hsa004500.47913404
72Vibrio cholerae infection_Homo sapiens_hsa051100.47850998
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47458242
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47432927
75ABC transporters_Homo sapiens_hsa020100.45560828
76Biosynthesis of amino acids_Homo sapiens_hsa012300.45527415
77Galactose metabolism_Homo sapiens_hsa000520.45340519
78Viral carcinogenesis_Homo sapiens_hsa052030.44247908
79Butanoate metabolism_Homo sapiens_hsa006500.44084876
80Propanoate metabolism_Homo sapiens_hsa006400.43731478
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43619064
82Herpes simplex infection_Homo sapiens_hsa051680.42889668
83Fatty acid elongation_Homo sapiens_hsa000620.42186087
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41337734
85Epstein-Barr virus infection_Homo sapiens_hsa051690.38077071
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36922654
87Phenylalanine metabolism_Homo sapiens_hsa003600.36510277
88Olfactory transduction_Homo sapiens_hsa047400.35545897
89Carbon metabolism_Homo sapiens_hsa012000.35369281
90Insulin secretion_Homo sapiens_hsa049110.34971506
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34400061
92Tyrosine metabolism_Homo sapiens_hsa003500.34373158
93Allograft rejection_Homo sapiens_hsa053300.33251163
94TGF-beta signaling pathway_Homo sapiens_hsa043500.33174394
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30753596
96Histidine metabolism_Homo sapiens_hsa003400.30566331
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30112275
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29936210
99p53 signaling pathway_Homo sapiens_hsa041150.29887715
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25894770
101Chemical carcinogenesis_Homo sapiens_hsa052040.25886327
102Caffeine metabolism_Homo sapiens_hsa002320.24800334
103Antigen processing and presentation_Homo sapiens_hsa046120.23399030
104Malaria_Homo sapiens_hsa051440.22894595
105Type I diabetes mellitus_Homo sapiens_hsa049400.22882927
106Thyroid cancer_Homo sapiens_hsa052160.22486069
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22081761
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21667333
109beta-Alanine metabolism_Homo sapiens_hsa004100.19738438
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18565847
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.18472030
112Legionellosis_Homo sapiens_hsa051340.17828013
113Taste transduction_Homo sapiens_hsa047420.16253954
114Fructose and mannose metabolism_Homo sapiens_hsa000510.16196116
115Circadian rhythm_Homo sapiens_hsa047100.15805188
116Other glycan degradation_Homo sapiens_hsa005110.15725451
117Asthma_Homo sapiens_hsa053100.15569991
118Fatty acid degradation_Homo sapiens_hsa000710.15502619
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13182628
120HTLV-I infection_Homo sapiens_hsa051660.13000215
121Sphingolipid metabolism_Homo sapiens_hsa006000.11507032
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10748603
123HIF-1 signaling pathway_Homo sapiens_hsa040660.10611137
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.06681901
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.02787826
126Fatty acid biosynthesis_Homo sapiens_hsa000610.01081819
127Mineral absorption_Homo sapiens_hsa04978-0.0060379

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