RFFL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)6.62723593
2axon ensheathment in central nervous system (GO:0032291)6.62723593
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.24104314
4negative regulation of cell killing (GO:0031342)5.24104314
5positive regulation of gamma-delta T cell activation (GO:0046645)4.67711921
6fatty acid elongation (GO:0030497)4.49418151
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48373821
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37097435
9cellular response to interleukin-15 (GO:0071350)4.33313396
10response to interleukin-15 (GO:0070672)4.30553472
11regulation of B cell receptor signaling pathway (GO:0050855)4.08849258
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02625309
13antigen processing and presentation of endogenous antigen (GO:0019883)4.00971284
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91261320
15erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.84846382
16L-phenylalanine catabolic process (GO:0006559)3.84846382
17amyloid precursor protein metabolic process (GO:0042982)3.79721716
18activated T cell proliferation (GO:0050798)3.76749407
19positive regulation by symbiont of host defense response (GO:0052509)3.63653415
20modulation by symbiont of host defense response (GO:0052031)3.63653415
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.63653415
22modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.63653415
23positive regulation by organism of defense response of other organism involved in symbiotic interact3.63653415
24modulation by symbiont of host immune response (GO:0052553)3.63653415
25heme transport (GO:0015886)3.58886329
26cellular extravasation (GO:0045123)3.58156840
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.55487936
28regulation of gamma-delta T cell activation (GO:0046643)3.55413700
29amyloid precursor protein catabolic process (GO:0042987)3.54167990
30neutrophil activation (GO:0042119)3.52948128
31leukocyte aggregation (GO:0070486)3.52549901
32negative T cell selection (GO:0043383)3.52516875
33negative thymic T cell selection (GO:0045060)3.47118375
34L-phenylalanine metabolic process (GO:0006558)3.46688163
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.46688163
36tolerance induction (GO:0002507)3.42362059
37response to methylmercury (GO:0051597)3.38521057
38regulation of regulatory T cell differentiation (GO:0045589)3.37118760
39detection of other organism (GO:0098543)3.35940004
40interferon-gamma production (GO:0032609)3.35646270
41negative regulation of T cell mediated immunity (GO:0002710)3.35479750
42L-serine metabolic process (GO:0006563)3.31750445
43ensheathment of neurons (GO:0007272)3.30681251
44axon ensheathment (GO:0008366)3.30681251
45myelin maintenance (GO:0043217)3.30086544
46negative regulation of interleukin-12 production (GO:0032695)3.26839900
47macrophage activation involved in immune response (GO:0002281)3.26493324
48myelination (GO:0042552)3.22836160
49serine family amino acid biosynthetic process (GO:0009070)3.22086208
50regulation of interferon-beta biosynthetic process (GO:0045357)3.21247742
51fusion of sperm to egg plasma membrane (GO:0007342)3.19725233
52granulocyte activation (GO:0036230)3.16184433
53detection of bacterium (GO:0016045)3.15847316
54positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.15510846
55regulation of gamma-delta T cell differentiation (GO:0045586)3.14009120
56regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.11266892
57regulation of alpha-beta T cell proliferation (GO:0046640)3.11183045
58neutrophil activation involved in immune response (GO:0002283)3.06571121
59negative regulation of macroautophagy (GO:0016242)3.02559108
60pentose metabolic process (GO:0019321)3.02357240
61multicellular organism reproduction (GO:0032504)3.00363160
62response to type I interferon (GO:0034340)3.00336183
63regulation of T cell mediated cytotoxicity (GO:0001914)3.00028415
64cellular response to type I interferon (GO:0071357)2.99899753
65type I interferon signaling pathway (GO:0060337)2.99899753
66aromatic amino acid family catabolic process (GO:0009074)2.98170238
67dendritic cell migration (GO:0036336)2.97068161
68detection of molecule of bacterial origin (GO:0032490)2.96666993
69creatine metabolic process (GO:0006600)2.96573478
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.96398559
71piRNA metabolic process (GO:0034587)2.95618389
72positive T cell selection (GO:0043368)2.94065368
73dendritic cell chemotaxis (GO:0002407)2.92909653
74cellular response to ethanol (GO:0071361)2.92068751
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91219053
76microglial cell activation (GO:0001774)2.91021167
77negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.90282210
78negative regulation of translation, ncRNA-mediated (GO:0040033)2.90282210
79regulation of translation, ncRNA-mediated (GO:0045974)2.90282210
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.90009999
81T cell migration (GO:0072678)2.89854926
82detection of external biotic stimulus (GO:0098581)2.89600846
83regulation of lipoprotein metabolic process (GO:0050746)2.89572805
84cholesterol biosynthetic process (GO:0006695)2.88918653
85negative regulation of T-helper cell differentiation (GO:0045623)2.85158124
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.85158124
87myeloid cell activation involved in immune response (GO:0002275)2.83984407
88negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.82318313
89cysteine metabolic process (GO:0006534)2.82241280
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.81583729
91leukocyte degranulation (GO:0043299)2.80670575
92negative regulation of interleukin-1 beta production (GO:0032691)2.79437886
93negative regulation of leukocyte mediated immunity (GO:0002704)2.78169201
94serine family amino acid metabolic process (GO:0009069)2.78042361
95mast cell activation (GO:0045576)2.75767804
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71742725
97regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70710939
98protoporphyrinogen IX biosynthetic process (GO:0006782)2.70096119
99negative regulation of cAMP-mediated signaling (GO:0043951)2.68074303
100interferon-gamma-mediated signaling pathway (GO:0060333)2.67782567
101positive regulation of cellular amine metabolic process (GO:0033240)2.66920780
102negative regulation of adaptive immune response (GO:0002820)2.66213463
103regulation of interleukin-12 biosynthetic process (GO:0045075)2.66108388
104positive regulation of granulocyte differentiation (GO:0030854)2.65826383
105long-chain fatty acid biosynthetic process (GO:0042759)2.65661988
106regulation of memory T cell differentiation (GO:0043380)2.65360662
107regulation of protein glycosylation (GO:0060049)2.64682460
108protoporphyrinogen IX metabolic process (GO:0046501)2.64646769
109positive regulation of interferon-alpha production (GO:0032727)2.64279135
110response to lipoprotein particle (GO:0055094)2.63925982
111immunoglobulin mediated immune response (GO:0016064)2.62969137
112regulation of interferon-alpha production (GO:0032647)2.62295618
113neutrophil mediated immunity (GO:0002446)2.62167492
114regulation of RIG-I signaling pathway (GO:0039535)2.61179904
115negative regulation of interleukin-1 production (GO:0032692)2.60979976
116alpha-beta T cell differentiation (GO:0046632)2.60604412
117defense response to protozoan (GO:0042832)2.60009415
118very long-chain fatty acid metabolic process (GO:0000038)2.59515897
119regulation of T cell tolerance induction (GO:0002664)2.59242256
120cytidine deamination (GO:0009972)2.58883749
121cytidine metabolic process (GO:0046087)2.58883749
122cytidine catabolic process (GO:0006216)2.58883749
123DNA methylation involved in gamete generation (GO:0043046)2.58841727
124sperm motility (GO:0030317)2.58735477
125reproduction (GO:0000003)2.58597046
126negative regulation of B cell proliferation (GO:0030889)2.57634767
127negative regulation of alpha-beta T cell activation (GO:0046636)2.57477781
128T cell selection (GO:0045058)2.56342067
129positive thymic T cell selection (GO:0045059)2.56174131
130response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.55774156
131response to host immune response (GO:0052572)2.55774156
132B cell receptor signaling pathway (GO:0050853)2.54728354
133regulation of leukocyte mediated cytotoxicity (GO:0001910)2.54683050
134positive regulation of lipoprotein lipase activity (GO:0051006)2.54329569
135positive regulation of triglyceride lipase activity (GO:0061365)2.54329569
136acrosome reaction (GO:0007340)2.53579696
137negative regulation of innate immune response (GO:0045824)2.53451803
138sterol biosynthetic process (GO:0016126)2.49642880
139respiratory burst (GO:0045730)2.48449901
140positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.47240508
141glycine metabolic process (GO:0006544)2.46350031
142positive regulation of toll-like receptor signaling pathway (GO:0034123)2.43284643
143centriole replication (GO:0007099)2.40629213
144iron coordination entity transport (GO:1901678)2.39945244
145glutathione derivative biosynthetic process (GO:1901687)2.39039395
146glutathione derivative metabolic process (GO:1901685)2.39039395
147amino acid salvage (GO:0043102)2.37785090
148L-methionine salvage (GO:0071267)2.37785090
149L-methionine biosynthetic process (GO:0071265)2.37785090
150sperm-egg recognition (GO:0035036)2.36517683
151membrane protein intracellular domain proteolysis (GO:0031293)2.35442461
152glycerophospholipid catabolic process (GO:0046475)2.35026899
153DNA deamination (GO:0045006)2.34159753
154disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.33417409
155killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.33417409
156microtubule polymerization or depolymerization (GO:0031109)2.32829677
157serine family amino acid catabolic process (GO:0009071)2.31821273
158isoprenoid biosynthetic process (GO:0008299)2.31068513
159tissue regeneration (GO:0042246)2.30180056
160glyoxylate metabolic process (GO:0046487)2.29014452
161plasma lipoprotein particle clearance (GO:0034381)2.26532461
162cofactor catabolic process (GO:0051187)2.26362165
163heme metabolic process (GO:0042168)2.25910672
164leukocyte migration involved in inflammatory response (GO:0002523)2.25434302
165response to lead ion (GO:0010288)2.25333816
166peptidyl-glutamic acid carboxylation (GO:0017187)2.24093624
167protein carboxylation (GO:0018214)2.24093624
168regulation of triglyceride catabolic process (GO:0010896)2.22899510
169indole-containing compound catabolic process (GO:0042436)2.22835893
170indolalkylamine catabolic process (GO:0046218)2.22835893
171tryptophan catabolic process (GO:0006569)2.22835893
172bile acid biosynthetic process (GO:0006699)2.21790593
173GPI anchor biosynthetic process (GO:0006506)2.21744761
174regulation of cholesterol metabolic process (GO:0090181)2.20155637
175response to peptidoglycan (GO:0032494)2.20026652
176mitochondrion degradation (GO:0000422)2.19828774
177regulation of collateral sprouting (GO:0048670)2.19701433
178long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.18822179
179negative regulation of chemokine production (GO:0032682)2.17983666
180pantothenate metabolic process (GO:0015939)2.16820722
181positive regulation of B cell differentiation (GO:0045579)2.16389112
182N-acetylneuraminate metabolic process (GO:0006054)2.15902510
183aromatic amino acid family metabolic process (GO:0009072)2.15534636
184cell-cell recognition (GO:0009988)2.14907577
185cell wall macromolecule metabolic process (GO:0044036)2.14791353
186cell wall macromolecule catabolic process (GO:0016998)2.14791353
187response to mercury ion (GO:0046689)2.13883779
188cellular modified amino acid biosynthetic process (GO:0042398)2.13731042
189male meiosis (GO:0007140)2.13206422
190male meiosis I (GO:0007141)2.11995031
191bile acid metabolic process (GO:0008206)2.10516560
192heme biosynthetic process (GO:0006783)2.09120943
193binding of sperm to zona pellucida (GO:0007339)2.08035117
194L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.08034532
195cofactor transport (GO:0051181)2.07420082

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.25386405
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14893571
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.09587246
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.66366687
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.46556648
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.29549359
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.17120041
8RUNX_20019798_ChIP-Seq_JUKART_Human2.77087154
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.73882762
10SCL_19346495_ChIP-Seq_HPC-7_Human2.65881844
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59375092
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.49678267
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49038982
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.45087878
15PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37324080
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.30535083
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27537535
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24436357
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.20734971
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.20439326
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18975408
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.17682860
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.15588801
24IRF8_27001747_Chip-Seq_BMDM_Mouse2.10288860
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04784362
26* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01779380
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.99491016
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91238736
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88567033
30STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.86149964
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84051481
32* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.80169842
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.77895768
34AR_21909140_ChIP-Seq_LNCAP_Human1.77031793
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.73866120
36ZNF274_21170338_ChIP-Seq_K562_Hela1.73793822
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73307684
38VDR_22108803_ChIP-Seq_LS180_Human1.72271996
39VDR_24787735_ChIP-Seq_THP-1_Human1.68120687
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67010335
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.63134983
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62531836
43KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58589500
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58210509
45E2F7_22180533_ChIP-Seq_HELA_Human1.54176940
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53091903
47CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50499609
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.50069702
49SPI1_23547873_ChIP-Seq_NB4_Human1.49026270
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.46910943
51ER_23166858_ChIP-Seq_MCF-7_Human1.44426139
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41086742
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40950859
54* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37676663
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36765159
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34973508
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29689478
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29055984
59FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27981542
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27028169
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.27019737
62* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26996331
63VDR_24763502_ChIP-Seq_THP-1_Human1.26563886
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.26532985
65GATA1_19941826_ChIP-Seq_K562_Human1.25892825
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25773101
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24541209
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24184595
69BCAT_22108803_ChIP-Seq_LS180_Human1.23767485
70* SPI1_23127762_ChIP-Seq_K562_Human1.22529213
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21216173
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21103746
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20956734
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20314061
75RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20277627
76KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.19773413
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.19773413
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.19773413
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19722963
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19599384
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18907552
82* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16638092
83CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16167411
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15931421
85* RUNX1_22412390_ChIP-Seq_EML_Mouse1.15195269
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.14463034
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14093860
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13030295
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12723444
90ELF1_17652178_ChIP-ChIP_JURKAT_Human1.12655246
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12435250
92SMRT_27268052_Chip-Seq_Bcells_Human1.11520738
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11010495
94GABP_17652178_ChIP-ChIP_JURKAT_Human1.10836413
95JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10319012
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.09753573
97FOXM1_23109430_ChIP-Seq_U2OS_Human1.09176995
98* VDR_23849224_ChIP-Seq_CD4+_Human1.07043429
99* IRF1_19129219_ChIP-ChIP_H3396_Human1.06235196
100* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04934876
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04859885
102EST1_17652178_ChIP-ChIP_JURKAT_Human1.04476343
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04230163
104GATA2_21666600_ChIP-Seq_HMVEC_Human1.04108026
105MYB_26560356_Chip-Seq_TH1_Human1.04026529
106PU_27001747_Chip-Seq_BMDM_Mouse1.03607682
107OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03258483
108GATA3_26560356_Chip-Seq_TH1_Human1.02814573
109* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02733194
110FOXO3_23340844_ChIP-Seq_DLD1_Human1.01865751
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01706051
112GATA1_19941827_ChIP-Seq_MEL_Mouse1.01627520
113P300_19829295_ChIP-Seq_ESCs_Human1.01014293
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00886618
115SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00193285
116IGF1R_20145208_ChIP-Seq_DFB_Human0.99861133
117MAF_26560356_Chip-Seq_TH1_Human0.99840741
118KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99715912
119VDR_21846776_ChIP-Seq_THP-1_Human0.99683757
120* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98100202
121CRX_20693478_ChIP-Seq_RETINA_Mouse0.97326878
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96695603
123* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96357105
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96341216
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.96146876
126BCOR_27268052_Chip-Seq_Bcells_Human0.95982508
127STAT3_23295773_ChIP-Seq_U87_Human0.95187950
128FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94613629
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94380524
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.92899552
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92869492
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92196417
133TAF15_26573619_Chip-Seq_HEK293_Human0.91762389
134FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91481535
135CDX2_22108803_ChIP-Seq_LS180_Human0.91386106
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91231903
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.91215876
138GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91091380
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.90248107
140NANOG_19829295_ChIP-Seq_ESCs_Human0.89954598
141SOX2_19829295_ChIP-Seq_ESCs_Human0.89954598
142GATA1_22025678_ChIP-Seq_K562_Human0.89866229
143KDM5A_27292631_Chip-Seq_BREAST_Human0.89631071
144NANOG_20526341_ChIP-Seq_ESCs_Human0.88955242
145ETS1_20019798_ChIP-Seq_JURKAT_Human0.88380351
146MYB_26560356_Chip-Seq_TH2_Human0.87960459
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87649047
148TCF4_23295773_ChIP-Seq_U87_Human0.87544008
149FLI1_21867929_ChIP-Seq_TH2_Mouse0.87320784
150VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86705150
151P53_22387025_ChIP-Seq_ESCs_Mouse0.86379037
152GBX2_23144817_ChIP-Seq_PC3_Human0.85653719
153PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85168939
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84685827
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.84685827
156GATA4_25053715_ChIP-Seq_YYC3_Human0.83728287
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83545202
158* GATA3_27048872_Chip-Seq_THYMUS_Human0.83142670
159* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83130677
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81688889
161* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81631615
162FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81300835
163* STAT1_17558387_ChIP-Seq_HELA_Human0.80119203
164GATA3_26560356_Chip-Seq_TH2_Human0.79890107
165* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78456608
166GATA2_19941826_ChIP-Seq_K562_Human0.78431347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.52406950
2MP0009840_abnormal_foam_cell3.35743257
3MP0005410_abnormal_fertilization3.27324676
4MP0000920_abnormal_myelination3.14080191
5MP0002139_abnormal_hepatobiliary_system3.13470498
6MP0003656_abnormal_erythrocyte_physiolo2.82555799
7MP0008260_abnormal_autophagy2.80303819
8MP0005451_abnormal_body_composition2.59167227
9MP0005360_urolithiasis2.53678029
10MP0005085_abnormal_gallbladder_physiolo2.18316069
11MP0005058_abnormal_lysosome_morphology2.15765348
12MP0003950_abnormal_plasma_membrane2.13720200
13MP0005365_abnormal_bile_salt2.12423140
14MP0004147_increased_porphyrin_level2.12307120
15MP0002138_abnormal_hepatobiliary_system2.12165490
16MP0003724_increased_susceptibility_to2.07452962
17MP0003763_abnormal_thymus_physiology2.03136220
18MP0003195_calcinosis1.98437070
19MP0003191_abnormal_cellular_cholesterol1.96154647
20MP0008875_abnormal_xenobiotic_pharmacok1.93746817
21MP0006082_CNS_inflammation1.84844320
22MP0003186_abnormal_redox_activity1.77362760
23MP0003718_maternal_effect1.75424218
24MP0004381_abnormal_hair_follicle1.72553278
25MP0002419_abnormal_innate_immunity1.72349200
26MP0010155_abnormal_intestine_physiology1.71703813
27MP0005464_abnormal_platelet_physiology1.71245888
28MP0009785_altered_susceptibility_to1.70399972
29MP0003436_decreased_susceptibility_to1.61442809
30MP0005025_abnormal_response_to1.59059092
31MP0003690_abnormal_glial_cell1.58633066
32MP0000465_gastrointestinal_hemorrhage1.53365286
33MP0002277_abnormal_respiratory_mucosa1.47851004
34MP0002166_altered_tumor_susceptibility1.46830577
35MP0005671_abnormal_response_to1.45710577
36MP0001929_abnormal_gametogenesis1.43439059
37MP0005397_hematopoietic_system_phenotyp1.42823683
38MP0001545_abnormal_hematopoietic_system1.42823683
39MP0005075_abnormal_melanosome_morpholog1.42065260
40MP0008057_abnormal_DNA_replication1.41642401
41MP0003866_abnormal_defecation1.41486362
42MP0001873_stomach_inflammation1.40967565
43MP0001986_abnormal_taste_sensitivity1.40863747
44MP0005000_abnormal_immune_tolerance1.38648979
45MP0002148_abnormal_hypersensitivity_rea1.35303658
46MP0001764_abnormal_homeostasis1.34986662
47MP0009278_abnormal_bone_marrow1.33932133
48MP0009333_abnormal_splenocyte_physiolog1.33122880
49MP0008877_abnormal_DNA_methylation1.31942652
50MP0003172_abnormal_lysosome_physiology1.31622682
51MP0001835_abnormal_antigen_presentation1.31404783
52MP0005408_hypopigmentation1.30890534
53MP0002723_abnormal_immune_serum1.27400162
54MP0005332_abnormal_amino_acid1.25285112
55MP0008469_abnormal_protein_level1.22380505
56MP0000703_abnormal_thymus_morphology1.22018922
57MP0000383_abnormal_hair_follicle1.21965120
58MP0003453_abnormal_keratinocyte_physiol1.21393620
59MP0004019_abnormal_vitamin_homeostasis1.20071466
60MP0010678_abnormal_skin_adnexa1.18520897
61MP0003252_abnormal_bile_duct1.14548567
62MP0003698_abnormal_male_reproductive1.14540415
63MP0003300_gastrointestinal_ulcer1.13585693
64MP0000609_abnormal_liver_physiology1.12025499
65MP0002876_abnormal_thyroid_physiology1.11981024
66MP0002933_joint_inflammation1.11627457
67MP0002452_abnormal_antigen_presenting1.11446882
68MP0001485_abnormal_pinna_reflex1.10920972
69MP0000604_amyloidosis1.10809801
70MP0001851_eye_inflammation1.10401101
71MP0002006_tumorigenesis1.09580183
72MP0004883_abnormal_blood_vessel1.09491547
73MP0001800_abnormal_humoral_immune1.09022077
74MP0003787_abnormal_imprinting1.08614001
75MP0001666_abnormal_nutrient_absorption1.08575696
76MP0000015_abnormal_ear_pigmentation1.07726681
77MP0003303_peritoneal_inflammation1.06783080
78MP0002118_abnormal_lipid_homeostasis1.04725873
79MP0002210_abnormal_sex_determination1.02855756
80MP0001501_abnormal_sleep_pattern1.02609431
81MP0000689_abnormal_spleen_morphology0.99470268
82MP0002420_abnormal_adaptive_immunity0.99396726
83MP0001819_abnormal_immune_cell0.99222305
84MP0010329_abnormal_lipoprotein_level0.99175153
85MP0005174_abnormal_tail_pigmentation0.98327714
86MP0004742_abnormal_vestibular_system0.98070949
87MP0003136_yellow_coat_color0.97559103
88MP0002009_preneoplasia0.97305912
89MP0001790_abnormal_immune_system0.95853509
90MP0005387_immune_system_phenotype0.95853509
91MP0001845_abnormal_inflammatory_respons0.95581663
92MP0000685_abnormal_immune_system0.94184237
93MP0001145_abnormal_male_reproductive0.93267555
94MP0004043_abnormal_pH_regulation0.92237928
95MP0003011_delayed_dark_adaptation0.92149649
96MP0009763_increased_sensitivity_to0.92126773
97MP0003111_abnormal_nucleus_morphology0.91852757
98MP0000716_abnormal_immune_system0.91291054
99MP0000647_abnormal_sebaceous_gland0.90622454
100MP0002693_abnormal_pancreas_physiology0.90141640
101MP0005167_abnormal_blood-brain_barrier0.89998524
102MP0009765_abnormal_xenobiotic_induced0.89306645
103MP0003045_fibrosis0.88631777
104MP0000569_abnormal_digit_pigmentation0.88466980
105MP0005083_abnormal_biliary_tract0.88398287
106MP0004142_abnormal_muscle_tone0.87934028
107MP0002398_abnormal_bone_marrow0.87655209
108MP0001853_heart_inflammation0.87559426
109MP0005647_abnormal_sex_gland0.86884272
110MP0003693_abnormal_embryo_hatching0.86792362
111MP0000653_abnormal_sex_gland0.86763157
112MP0008872_abnormal_physiological_respon0.86013908
113MP0002928_abnormal_bile_duct0.85176798
114MP0005310_abnormal_salivary_gland0.85017068
115MP0001533_abnormal_skeleton_physiology0.84520103
116MP0005164_abnormal_response_to0.83756744
117MP0004947_skin_inflammation0.83518905
118MP0005584_abnormal_enzyme/coenzyme_acti0.82462695
119MP0003077_abnormal_cell_cycle0.81937740
120MP0002429_abnormal_blood_cell0.81598255
121MP0010094_abnormal_chromosome_stability0.81298761
122MP0005319_abnormal_enzyme/_coenzyme0.80752068
123MP0002405_respiratory_system_inflammati0.80608827
124MP0009764_decreased_sensitivity_to0.80223861
125MP0002161_abnormal_fertility/fecundity0.80159151
126MP0002254_reproductive_system_inflammat0.79866911
127MP0009643_abnormal_urine_homeostasis0.79662691
128MP0001663_abnormal_digestive_system0.78303284
129MP0002396_abnormal_hematopoietic_system0.77621682
130MP0005395_other_phenotype0.77243376
131MP0002722_abnormal_immune_system0.75956892
132MP0001919_abnormal_reproductive_system0.75808098
133MP0005636_abnormal_mineral_homeostasis0.75243995
134MP0001661_extended_life_span0.75232943
135MP0003943_abnormal_hepatobiliary_system0.71946459
136MP0003183_abnormal_peptide_metabolism0.71484906
137MP0003828_pulmonary_edema0.71328602
138MP0005551_abnormal_eye_electrophysiolog0.70359051
139MP0009115_abnormal_fat_cell0.68837090
140MP0002132_abnormal_respiratory_system0.66849511
141MP0001765_abnormal_ion_homeostasis0.65511435

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.62628896
2Optic neuritis (HP:0100653)4.62628896
3Orchitis (HP:0100796)4.29277576
4Myositis (HP:0100614)4.16347781
5Parakeratosis (HP:0001036)3.85732643
6Abnormal delayed hypersensitivity skin test (HP:0002963)3.71327240
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.62445303
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.58602419
9Abnormality of T cell number (HP:0011839)3.58226128
10Cerebral hypomyelination (HP:0006808)3.48099482
11Stomach cancer (HP:0012126)3.46798138
12Hypochromic microcytic anemia (HP:0004840)3.43100922
13Neurofibrillary tangles (HP:0002185)3.38408208
14Recurrent fungal infections (HP:0002841)3.35514958
15Keratoconjunctivitis (HP:0001096)3.35223737
16Elevated erythrocyte sedimentation rate (HP:0003565)3.35047723
17Intrahepatic cholestasis (HP:0001406)3.32471546
18Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.31111193
19Recurrent bacterial skin infections (HP:0005406)3.30089812
20T lymphocytopenia (HP:0005403)3.24815079
21Hypochromic anemia (HP:0001931)3.23811943
22Keratoconjunctivitis sicca (HP:0001097)3.21426924
23Abnormality of macrophages (HP:0004311)3.19968821
24Vasculitis (HP:0002633)3.15208629
25Encephalitis (HP:0002383)3.14836085
26Spastic paraparesis (HP:0002313)3.12935369
27Pulmonary infiltrates (HP:0002113)3.10737560
28Leukocytosis (HP:0001974)3.07780389
29Axonal loss (HP:0003447)3.04802612
30Prolonged neonatal jaundice (HP:0006579)3.02634405
31Degeneration of the lateral corticospinal tracts (HP:0002314)3.00855483
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.00855483
33Gastrointestinal infarctions (HP:0005244)2.96679163
34Hepatosplenomegaly (HP:0001433)2.91986451
35Abnormality of T cells (HP:0002843)2.88868236
36Recurrent abscess formation (HP:0002722)2.88022682
37Segmental peripheral demyelination/remyelination (HP:0003481)2.83113341
38Prolonged partial thromboplastin time (HP:0003645)2.82635446
39Recurrent gram-negative bacterial infections (HP:0005420)2.81147982
40Chronic mucocutaneous candidiasis (HP:0002728)2.80688881
41Recurrent cutaneous fungal infections (HP:0011370)2.80688881
42Meningitis (HP:0001287)2.76228357
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.74481319
44Peripheral hypomyelination (HP:0007182)2.71813924
45Abnormality of methionine metabolism (HP:0010901)2.71788214
46Eczematoid dermatitis (HP:0000976)2.67519076
47Spastic tetraparesis (HP:0001285)2.66982567
48Joint hemorrhage (HP:0005261)2.66951427
49Congenital ichthyosiform erythroderma (HP:0007431)2.66893765
50Panhypogammaglobulinemia (HP:0003139)2.65480713
51Slow saccadic eye movements (HP:0000514)2.62187642
52Vacuolated lymphocytes (HP:0001922)2.62171890
53Pulmonary embolism (HP:0002204)2.59886066
54IgG deficiency (HP:0004315)2.58418028
55Hemoptysis (HP:0002105)2.58266940
56Recurrent skin infections (HP:0001581)2.58237060
57Abnormality of T cell physiology (HP:0011840)2.58196734
58Hyperlipoproteinemia (HP:0010980)2.56673091
59Abnormality of eosinophils (HP:0001879)2.54691896
60Stomatitis (HP:0010280)2.54527030
61Abnormal auditory evoked potentials (HP:0006958)2.52178517
62Vascular calcification (HP:0004934)2.48628975
63Thyroiditis (HP:0100646)2.47603146
64Increased IgM level (HP:0003496)2.47509221
65Erythroderma (HP:0001019)2.47447946
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.47391550
67Severe combined immunodeficiency (HP:0004430)2.47002212
68Petechiae (HP:0000967)2.46856968
69Paraparesis (HP:0002385)2.46717849
70Mediastinal lymphadenopathy (HP:0100721)2.45586765
71Eosinophilia (HP:0001880)2.44220528
72Xanthomatosis (HP:0000991)2.43348250
73Autoimmune hemolytic anemia (HP:0001890)2.43315770
74Anorexia (HP:0002039)2.41490025
75Hyperglycinemia (HP:0002154)2.41464668
76Gingivitis (HP:0000230)2.41099944
77Sensory axonal neuropathy (HP:0003390)2.41097953
78Acanthocytosis (HP:0001927)2.39974680
79Gingival bleeding (HP:0000225)2.38424066
80Abnormality of B cell number (HP:0010975)2.37958733
81Hyperventilation (HP:0002883)2.33242816
82Purpura (HP:0000979)2.32175161
83Deep venous thrombosis (HP:0002625)2.29699202
84Onion bulb formation (HP:0003383)2.29682068
85Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26853271
86Abnormality of monocarboxylic acid metabolism (HP:0010996)2.24446260
87Impulsivity (HP:0100710)2.23345043
88Neoplasm of the tracheobronchial system (HP:0100552)2.21076197
89Abnormality of glycine metabolism (HP:0010895)2.19026028
90Abnormality of serine family amino acid metabolism (HP:0010894)2.19026028
91Autoimmune thrombocytopenia (HP:0001973)2.17319232
92Alveolar cell carcinoma (HP:0006519)2.16988089
93Dynein arm defect of respiratory motile cilia (HP:0012255)2.13950790
94Absent/shortened dynein arms (HP:0200106)2.13950790
95Attenuation of retinal blood vessels (HP:0007843)2.13574288
96Chronic diarrhea (HP:0002028)2.12311316
97Arterial thrombosis (HP:0004420)2.12018526
98Granulocytopenia (HP:0001913)2.11455954
99Abnormality of sulfur amino acid metabolism (HP:0004339)2.10801243
100Fair hair (HP:0002286)2.10441130
101Poikilocytosis (HP:0004447)2.10418470
102Episodic fever (HP:0001954)2.10005437
103Peripheral demyelination (HP:0011096)2.09628601
104Chest pain (HP:0100749)2.09553845
105Increased serum ferritin (HP:0003281)2.08050831
106Pustule (HP:0200039)2.07880568
107CNS hypomyelination (HP:0003429)2.07584711
108Complement deficiency (HP:0004431)2.05321739
109Urticaria (HP:0001025)2.04854524
110Hypobetalipoproteinemia (HP:0003563)2.02344724
111Fat malabsorption (HP:0002630)2.01695435
112Progressive inability to walk (HP:0002505)2.01605923
113Keratitis (HP:0000491)2.01029021
114Systemic lupus erythematosus (HP:0002725)2.00285438
115Amyloidosis (HP:0011034)2.00224019
116Steatorrhea (HP:0002570)1.99067323
117Birth length less than 3rd percentile (HP:0003561)1.97008634
118Congenital stationary night blindness (HP:0007642)1.94523205
119Abnormality of iron homeostasis (HP:0011031)1.93462356
120Cardiovascular calcification (HP:0011915)1.92884526
121Combined immunodeficiency (HP:0005387)1.92468707
122Glomerulonephritis (HP:0000099)1.91598537
123Hyperglycinuria (HP:0003108)1.90855001
124Epistaxis (HP:0000421)1.90645505
125Chronic otitis media (HP:0000389)1.90051933
126Abnormality of the pleura (HP:0002103)1.89460200
127Abnormality of the prostate (HP:0008775)1.89135950
128Recurrent viral infections (HP:0004429)1.88859848
129Abnormal spermatogenesis (HP:0008669)1.88797771
130Spontaneous hematomas (HP:0007420)1.87652909
131Abnormality of transition element cation homeostasis (HP:0011030)1.86175349
132Abnormality of serum amino acid levels (HP:0003112)1.85801057
133Cerebral inclusion bodies (HP:0100314)1.84160461
134Joint swelling (HP:0001386)1.84129391
1353-Methylglutaconic aciduria (HP:0003535)1.83584902
136Breast hypoplasia (HP:0003187)1.82754638
137Increased IgE level (HP:0003212)1.82671626
138Osteomyelitis (HP:0002754)1.82642083
139B lymphocytopenia (HP:0010976)1.82037160
140Hypercholesterolemia (HP:0003124)1.81652207
141Chronic obstructive pulmonary disease (HP:0006510)1.81019162
142Obstructive lung disease (HP:0006536)1.81019162
143Thrombophlebitis (HP:0004418)1.80997335
144Abolished electroretinogram (ERG) (HP:0000550)1.80895013
145Increased neuronal autofluorescent lipopigment (HP:0002074)1.80323132
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.77311986
147Hematochezia (HP:0002573)1.76229927
148Lymphopenia (HP:0001888)1.75871171
149Microcytic anemia (HP:0001935)1.75556580
150Prostate neoplasm (HP:0100787)1.75056232
151Megaloblastic anemia (HP:0001889)1.73547140
152Generalized hypopigmentation of hair (HP:0011358)1.73012033
153Clitoromegaly (HP:0000057)1.71332894
154IgM deficiency (HP:0002850)1.70954366
155Recurrent bronchitis (HP:0002837)1.69977261
156Ectropion (HP:0000656)1.69135392
157Stenosis of the external auditory canal (HP:0000402)1.69093692
158Paralysis (HP:0003470)1.68913276
159Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68829269
160Decreased circulating renin level (HP:0003351)1.67307492
161Duplicated collecting system (HP:0000081)1.66172657
162Metabolic alkalosis (HP:0200114)1.65569609
163Abnormality of the corticospinal tract (HP:0002492)1.65272847
164Abnormality of homocysteine metabolism (HP:0010919)1.65055212
165Homocystinuria (HP:0002156)1.65055212
166Decreased central vision (HP:0007663)1.63386582
167Absent septum pellucidum (HP:0001331)1.63329064
168Abnormality of the renal cortex (HP:0011035)1.61658082
169Prolonged bleeding time (HP:0003010)1.61653401
170Morphological abnormality of the inner ear (HP:0011390)1.61548351
171Gangrene (HP:0100758)1.61268423
172Ureteral duplication (HP:0000073)1.60757896
173Periodontitis (HP:0000704)1.60094741
174Increased density of long bones (HP:0006392)1.59924391
175Cellulitis (HP:0100658)1.59726017
176Patchy hypopigmentation of hair (HP:0011365)1.59501121
177Progressive neurologic deterioration (HP:0002344)1.58922639
178Widely spaced teeth (HP:0000687)1.58553671
179Abnormal enzyme/coenzyme activity (HP:0012379)1.58071671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB14.12887818
2STK394.09767094
3FRK3.85909070
4TAOK32.90120074
5PBK2.79481658
6MAPKAPK52.50123752
7RIPK42.39352576
8OXSR12.35677660
9SIK32.34701156
10BUB12.08407818
11TAOK12.04747451
12BLK2.00797336
13NLK1.83087067
14MET1.80662144
15STK161.78650242
16PKN11.75185541
17TESK21.74141585
18MAP4K11.73773332
19GRK61.71338967
20CLK11.63298933
21MAP3K141.60127542
22TNK21.59203309
23FES1.58532733
24IRAK41.57966549
25WEE11.54923143
26MUSK1.53983984
27MKNK11.43767380
28TNIK1.38903908
29STK41.36354000
30SYK1.34825012
31CSNK1G31.31705961
32JAK11.30330966
33TYK21.28503619
34ITK1.27684942
35EPHA31.26155687
36FGFR31.25150919
37CSNK1G11.23869432
38IKBKE1.23362934
39NEK21.22900746
40CSNK1A1L1.20372335
41ZAP701.19382095
42ACVR1B1.18410628
43STK31.16886280
44ICK1.15543718
45TBK11.15283628
46DYRK31.14342549
47STK101.12829062
48CAMKK21.11540306
49IKBKB1.10377362
50TGFBR21.08674057
51RPS6KA51.07175048
52TTK1.06779212
53PIM11.05575470
54WNK31.05069597
55ADRBK21.04848188
56CSF1R1.02939152
57PRKCQ1.02118300
58WNK41.00728292
59PLK41.00414913
60BCKDK0.99950679
61NME20.99943012
62MAP2K30.99481630
63PIK3CG0.98806807
64MST40.98396857
65IRAK30.97797822
66MAPK130.96906186
67TRIM280.95641789
68MARK30.95309829
69MELK0.95009213
70MKNK20.94714890
71NUAK10.94084024
72FGFR20.93358239
73SGK20.93110034
74MAP4K20.92442342
75DAPK20.89514389
76BTK0.89110200
77PNCK0.86533140
78MAP2K60.85449950
79FGR0.85234463
80STK110.84656303
81PRKCH0.84406658
82BMPR1B0.82924174
83CSK0.81012923
84NEK60.79776386
85TRPM70.78530935
86ERBB40.77451047
87DYRK20.76282252
88CHUK0.75206245
89MAP2K20.75012738
90HIPK20.74327020
91MAP3K20.74218667
92ABL20.72892684
93GSK3A0.72166427
94SGK2230.71698575
95SGK4940.71698575
96PINK10.71681992
97MAPK150.70632155
98YES10.69894012
99MAP3K110.69179131
100WNK10.67750688
101MAP3K80.66565107
102MAP3K10.65842012
103KIT0.64852791
104CSNK1G20.63895884
105INSRR0.63247112
106MAP3K60.62922976
107PRPF4B0.62888163
108BRSK20.62201843
109PAK10.60996033
110BRD40.60814795
111GRK70.59114163
112BMPR20.58958470
113MAP3K30.58806131
114IRAK20.58308107
115PIM20.57918688
116PAK30.57372861
117AKT30.57270646
118PDK20.57106289
119FGFR40.56737672
120CDK190.56576375
121MAP3K70.55230880
122SGK30.55032524
123EIF2AK10.54432237
124TYRO30.53942488
125TXK0.53722355
126TEC0.51453275
127LYN0.50052188
128BRAF0.49551365
129LCK0.49223072
130MATK0.49042170
131ZAK0.48585961
132IRAK10.48363594
133PDK10.48095084
134SIK20.47791846
135CDC70.46175356
136GRK10.46071875
137PRKAA20.45971230
138RPS6KA40.45778122
139KSR10.44602713
140CHEK20.44577035
141PDPK10.44358631
142JAK30.43278634
143MAP3K130.42573110
144PTK2B0.42572000
145HCK0.42195845
146PLK10.42099324
147JAK20.41933218
148MAPKAPK20.41843173
149MAPK110.41794779
150ABL10.41683862
151BMX0.41087151
152EIF2AK30.40883788
153STK240.39427247
154CDK70.39352813
155CAMK2G0.38858648
156SGK10.34865035
157PIK3CA0.34559936

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.75194603
2Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.77831313
3Primary immunodeficiency_Homo sapiens_hsa053402.74920750
4Steroid biosynthesis_Homo sapiens_hsa001002.64038318
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44424849
6Autoimmune thyroid disease_Homo sapiens_hsa053202.43808092
7Fatty acid elongation_Homo sapiens_hsa000622.40868782
8Folate biosynthesis_Homo sapiens_hsa007902.33477277
9Type I diabetes mellitus_Homo sapiens_hsa049402.19277524
10Osteoclast differentiation_Homo sapiens_hsa043802.17715884
11Staphylococcus aureus infection_Homo sapiens_hsa051502.17214395
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.12068683
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.06342459
14Histidine metabolism_Homo sapiens_hsa003402.03890951
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.01110978
16Ether lipid metabolism_Homo sapiens_hsa005651.94117935
17T cell receptor signaling pathway_Homo sapiens_hsa046601.89801962
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88172861
19Linoleic acid metabolism_Homo sapiens_hsa005911.79329900
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78684887
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65074148
22Nitrogen metabolism_Homo sapiens_hsa009101.62981249
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.62049459
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59593138
25Tuberculosis_Homo sapiens_hsa051521.56157491
26Complement and coagulation cascades_Homo sapiens_hsa046101.54687374
27Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54155697
28Vitamin digestion and absorption_Homo sapiens_hsa049771.49482805
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47128919
30Glutathione metabolism_Homo sapiens_hsa004801.46294341
31B cell receptor signaling pathway_Homo sapiens_hsa046621.45911532
32Peroxisome_Homo sapiens_hsa041461.44715286
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41946529
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40496510
35Retinol metabolism_Homo sapiens_hsa008301.36577949
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.32357892
37Dorso-ventral axis formation_Homo sapiens_hsa043201.29151532
38Chemokine signaling pathway_Homo sapiens_hsa040621.28703308
39Basal transcription factors_Homo sapiens_hsa030221.27603699
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.26042444
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25332183
42African trypanosomiasis_Homo sapiens_hsa051431.24846680
43Chemical carcinogenesis_Homo sapiens_hsa052041.24446237
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22143362
45TNF signaling pathway_Homo sapiens_hsa046681.21234845
46Arachidonic acid metabolism_Homo sapiens_hsa005901.21169215
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.18800430
48Drug metabolism - other enzymes_Homo sapiens_hsa009831.18583538
49Antigen processing and presentation_Homo sapiens_hsa046121.17164365
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.15617892
51beta-Alanine metabolism_Homo sapiens_hsa004101.13010618
52ABC transporters_Homo sapiens_hsa020101.12611564
53Pentose phosphate pathway_Homo sapiens_hsa000301.11801867
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09759282
55Selenocompound metabolism_Homo sapiens_hsa004501.09242328
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.09017075
57Influenza A_Homo sapiens_hsa051641.08747401
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06981389
59Arginine and proline metabolism_Homo sapiens_hsa003301.04718846
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03886829
61Rheumatoid arthritis_Homo sapiens_hsa053231.03760415
62Sphingolipid metabolism_Homo sapiens_hsa006001.02084095
63Sulfur relay system_Homo sapiens_hsa041221.01472036
64Regulation of autophagy_Homo sapiens_hsa041400.98366777
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98269054
66Other glycan degradation_Homo sapiens_hsa005110.95627527
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95254232
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94690017
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.93833800
70Protein export_Homo sapiens_hsa030600.92547998
71RNA polymerase_Homo sapiens_hsa030200.88764727
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87958794
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86342942
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.84705387
75Sulfur metabolism_Homo sapiens_hsa009200.84382125
76Viral myocarditis_Homo sapiens_hsa054160.84222245
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84054148
78Toxoplasmosis_Homo sapiens_hsa051450.83204336
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82710564
80Hepatitis C_Homo sapiens_hsa051600.82461902
81Caffeine metabolism_Homo sapiens_hsa002320.80968998
82Hepatitis B_Homo sapiens_hsa051610.80930757
83Malaria_Homo sapiens_hsa051440.80825041
84Asthma_Homo sapiens_hsa053100.80279699
85Lysosome_Homo sapiens_hsa041420.79232850
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77602086
87Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77332762
88PPAR signaling pathway_Homo sapiens_hsa033200.77100127
89FoxO signaling pathway_Homo sapiens_hsa040680.77079549
90Arginine biosynthesis_Homo sapiens_hsa002200.75892742
91Graft-versus-host disease_Homo sapiens_hsa053320.75749826
92DNA replication_Homo sapiens_hsa030300.75557738
93Tryptophan metabolism_Homo sapiens_hsa003800.73260573
94Fat digestion and absorption_Homo sapiens_hsa049750.70682876
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70435360
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69827489
97Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69804116
98Acute myeloid leukemia_Homo sapiens_hsa052210.68294697
99Leishmaniasis_Homo sapiens_hsa051400.67727050
100Propanoate metabolism_Homo sapiens_hsa006400.67646139
101Prolactin signaling pathway_Homo sapiens_hsa049170.67303123
102Systemic lupus erythematosus_Homo sapiens_hsa053220.66515075
103Pyrimidine metabolism_Homo sapiens_hsa002400.66434639
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65897447
105Fatty acid degradation_Homo sapiens_hsa000710.62897593
106Herpes simplex infection_Homo sapiens_hsa051680.62736816
107Homologous recombination_Homo sapiens_hsa034400.62034215
108Glycerolipid metabolism_Homo sapiens_hsa005610.60858656
109Hematopoietic cell lineage_Homo sapiens_hsa046400.59504715
110Circadian rhythm_Homo sapiens_hsa047100.57985011
111Non-small cell lung cancer_Homo sapiens_hsa052230.57828180
112Platelet activation_Homo sapiens_hsa046110.57116855
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.57035540
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56797145
115Metabolic pathways_Homo sapiens_hsa011000.56781165
116Proteasome_Homo sapiens_hsa030500.55694518
117Legionellosis_Homo sapiens_hsa051340.54285310
118Butanoate metabolism_Homo sapiens_hsa006500.54089897
119Pertussis_Homo sapiens_hsa051330.53594164
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.52147159
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.50515838
122Insulin resistance_Homo sapiens_hsa049310.50076083
123Type II diabetes mellitus_Homo sapiens_hsa049300.50071473
124Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49808683
125Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49807675
126Fatty acid metabolism_Homo sapiens_hsa012120.49254022
127Measles_Homo sapiens_hsa051620.48734955
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48357461
129Cell cycle_Homo sapiens_hsa041100.45762383
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.44944161
131Fanconi anemia pathway_Homo sapiens_hsa034600.43213996
132Non-homologous end-joining_Homo sapiens_hsa034500.43179843
133Epstein-Barr virus infection_Homo sapiens_hsa051690.42681477
134Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42653628
135Fatty acid biosynthesis_Homo sapiens_hsa000610.42265228
136Apoptosis_Homo sapiens_hsa042100.41741820
137Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40896640
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40825722
139Base excision repair_Homo sapiens_hsa034100.40327588
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.40323456
141Allograft rejection_Homo sapiens_hsa053300.37340503
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37227672
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.37010324
144Inositol phosphate metabolism_Homo sapiens_hsa005620.36813581
145One carbon pool by folate_Homo sapiens_hsa006700.36789388
146Pancreatic cancer_Homo sapiens_hsa052120.34011361
147Choline metabolism in cancer_Homo sapiens_hsa052310.33846374

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