RFNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.76642157
2proline metabolic process (GO:0006560)7.43438990
3transcription from mitochondrial promoter (GO:0006390)7.41362158
4replication fork processing (GO:0031297)6.22443603
5embryonic process involved in female pregnancy (GO:0060136)6.04690678
6positive regulation of protein homooligomerization (GO:0032464)6.03408891
7DNA deamination (GO:0045006)5.71369797
8oxidative demethylation (GO:0070989)5.58933958
9establishment of apical/basal cell polarity (GO:0035089)5.56157982
10regulation of protein homooligomerization (GO:0032462)5.54247401
11establishment or maintenance of monopolar cell polarity (GO:0061339)5.06759657
12establishment of monopolar cell polarity (GO:0061162)5.06759657
13maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.04652690
14regulation of integrin activation (GO:0033623)5.03390267
15negative regulation of JAK-STAT cascade (GO:0046426)4.97158134
16mitotic G1 DNA damage checkpoint (GO:0031571)4.65789746
17mitochondrial DNA metabolic process (GO:0032042)4.63354557
18negative regulation of protein oligomerization (GO:0032460)4.46555762
19cell migration in hindbrain (GO:0021535)4.37183686
20poly(A)+ mRNA export from nucleus (GO:0016973)4.32476416
21negative regulation of Ras GTPase activity (GO:0034261)4.26647180
22DNA strand renaturation (GO:0000733)4.25572563
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.25322551
24synaptic vesicle endocytosis (GO:0048488)4.21512555
25glutamine family amino acid biosynthetic process (GO:0009084)4.12971704
26G1 DNA damage checkpoint (GO:0044783)4.09730993
27viral mRNA export from host cell nucleus (GO:0046784)4.05187580
28somatic hypermutation of immunoglobulin genes (GO:0016446)4.04552094
29somatic diversification of immune receptors via somatic mutation (GO:0002566)4.04552094
30mitotic G1/S transition checkpoint (GO:0044819)4.02788587
31mannose metabolic process (GO:0006013)3.98208897
32neuromuscular process controlling posture (GO:0050884)3.96979107
33establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.94100396
34mitochondrion transport along microtubule (GO:0047497)3.94100396
35negative regulation of erythrocyte differentiation (GO:0045647)3.91539461
36cellular response to ATP (GO:0071318)3.90151551
37regulation of cAMP-dependent protein kinase activity (GO:2000479)3.83391642
38regulation of translational fidelity (GO:0006450)3.73293402
39positive regulation of dendritic spine morphogenesis (GO:0061003)3.71764880
40mRNA cleavage (GO:0006379)3.68824950
41negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.67265783
42basement membrane organization (GO:0071711)3.64516284
43signal complex assembly (GO:0007172)3.63573837
44embryonic placenta development (GO:0001892)3.63327779
45negative regulation of cell cycle arrest (GO:0071157)3.62412412
46peptidyl-glutamic acid carboxylation (GO:0017187)3.61332046
47protein carboxylation (GO:0018214)3.61332046
48regulation of protein oligomerization (GO:0032459)3.52559135
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.52314691
50regulation of extracellular matrix disassembly (GO:0010715)3.50322418
51regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50182200
52establishment of mitochondrion localization (GO:0051654)3.46241576
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43395280
54convergent extension (GO:0060026)3.43316023
55DNA integration (GO:0015074)3.42581732
56glial cell migration (GO:0008347)3.41941489
57negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.41901910
58GDP-mannose metabolic process (GO:0019673)3.40170840
59positive regulation of triglyceride lipase activity (GO:0061365)3.38464736
60positive regulation of lipoprotein lipase activity (GO:0051006)3.38464736
61regulation of early endosome to late endosome transport (GO:2000641)3.36642992
62negative regulation of cell size (GO:0045792)3.35305317
63labyrinthine layer development (GO:0060711)3.30918528
64respiratory system process (GO:0003016)3.30590507
65histone H4-K12 acetylation (GO:0043983)3.29784373
66planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29714989
67positive regulation of extracellular matrix organization (GO:1903055)3.27833092
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25745238
69activation of Rac GTPase activity (GO:0032863)3.25009455
70mitochondrial RNA metabolic process (GO:0000959)3.24699557
71positive regulation of developmental pigmentation (GO:0048087)3.21012772
72neuromuscular process controlling balance (GO:0050885)3.20036039
73negative regulation of fibrinolysis (GO:0051918)3.16378680
74negative regulation of heart rate (GO:0010459)3.15809003
75negative regulation of mRNA processing (GO:0050686)3.15711680
76synaptic vesicle exocytosis (GO:0016079)3.14995374
77adherens junction assembly (GO:0034333)3.09626332
78COPI coating of Golgi vesicle (GO:0048205)3.09162057
79Golgi transport vesicle coating (GO:0048200)3.09162057
80positive regulation of protein oligomerization (GO:0032461)3.08866927
81apoptotic process involved in morphogenesis (GO:0060561)3.08835576
82cell-substrate adherens junction assembly (GO:0007045)3.08238098
83focal adhesion assembly (GO:0048041)3.08238098
84regulation of cholesterol biosynthetic process (GO:0045540)3.08081392
85formation of translation preinitiation complex (GO:0001731)3.06778656
86base-excision repair (GO:0006284)3.03156587
87cell-cell junction maintenance (GO:0045217)3.02952572
88spinal cord development (GO:0021510)2.99789523
89locomotory exploration behavior (GO:0035641)2.99463359
90membrane tubulation (GO:0097320)2.98850927
91embryonic camera-type eye development (GO:0031076)2.98010570
92regulation of extracellular matrix organization (GO:1903053)2.97634432
93auditory receptor cell stereocilium organization (GO:0060088)2.96317730
94positive regulation of circadian rhythm (GO:0042753)2.95323590
95regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94934717
96dosage compensation (GO:0007549)2.93938770
97negative regulation of fatty acid biosynthetic process (GO:0045717)2.92858030
98modulation by virus of host process (GO:0019054)2.91187974
99regulation of cholesterol homeostasis (GO:2000188)2.91033305
100regulation of plasminogen activation (GO:0010755)2.90627625
101base-excision repair, AP site formation (GO:0006285)2.90427650
102regulation of respiratory system process (GO:0044065)2.89308889
103pinocytosis (GO:0006907)2.89099045
104pyrimidine nucleotide catabolic process (GO:0006244)2.88778165
105modulation by symbiont of host cellular process (GO:0044068)2.87522998
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.87223334
107semaphorin-plexin signaling pathway (GO:0071526)2.87128911
108positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.86687272
109regulation of membrane depolarization (GO:0003254)2.86095411
110stress fiber assembly (GO:0043149)2.85154120
111negative regulation of response to food (GO:0032096)2.84614194
112negative regulation of appetite (GO:0032099)2.84614194
113regulation of cell size (GO:0008361)2.84528489
114positive regulation of receptor recycling (GO:0001921)2.84430047
115protein retention in ER lumen (GO:0006621)2.83802171
116regulation of mitochondrial depolarization (GO:0051900)2.83501068
117N-glycan processing (GO:0006491)2.83381495
118barbed-end actin filament capping (GO:0051016)2.83196266
119protein targeting to vacuole (GO:0006623)2.83102041
120protein targeting to lysosome (GO:0006622)2.83102041
121establishment of protein localization to vacuole (GO:0072666)2.83102041
122face development (GO:0060324)2.82784384
123mitotic nuclear envelope reassembly (GO:0007084)2.82774384
124nuclear envelope reassembly (GO:0031468)2.82774384
125adhesion of symbiont to host (GO:0044406)2.82664366
126regulation of short-term neuronal synaptic plasticity (GO:0048172)2.82106261
127NADH metabolic process (GO:0006734)2.80114551
128positive regulation by host of viral transcription (GO:0043923)2.79696733
129double-strand break repair via nonhomologous end joining (GO:0006303)2.79061764
130non-recombinational repair (GO:0000726)2.79061764
131retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79016279
132regulation of cholesterol esterification (GO:0010872)2.78620130
133termination of RNA polymerase II transcription (GO:0006369)2.77877878
134regulation of response to reactive oxygen species (GO:1901031)2.77441457
135tooth mineralization (GO:0034505)2.76628087
136protein-lipid complex assembly (GO:0065005)2.76497535
137nodal signaling pathway (GO:0038092)2.74843615
138protein localization to endosome (GO:0036010)2.74815081
139positive regulation of fatty acid biosynthetic process (GO:0045723)2.74335083
140negative regulation of fatty acid transport (GO:2000192)2.74331787
141regulation of apoptotic cell clearance (GO:2000425)2.72321718
142regulation of fibrinolysis (GO:0051917)2.71218772
143cell-substrate junction assembly (GO:0007044)2.69929857
144low-density lipoprotein particle clearance (GO:0034383)2.68756755
145regulation of ARF GTPase activity (GO:0032312)2.68475990
146activation of MAPKKK activity (GO:0000185)2.65776292
147plasma lipoprotein particle assembly (GO:0034377)2.62965619
148embryo implantation (GO:0007566)2.62386969
149positive regulation of Cdc42 GTPase activity (GO:0043089)2.60515892
150regulation of cholesterol metabolic process (GO:0090181)2.59090697
151atrioventricular valve morphogenesis (GO:0003181)2.58465525
152regulation of glucose import in response to insulin stimulus (GO:2001273)2.57838893
153positive regulation of blood vessel endothelial cell migration (GO:0043536)2.55794860
154phospholipid efflux (GO:0033700)2.52186180
155complement activation, alternative pathway (GO:0006957)2.50564728
156urea cycle (GO:0000050)2.50237012
157triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.50222142
158vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.49823268
159skin morphogenesis (GO:0043589)2.49119480
160positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.44521170
161regulation of fatty acid biosynthetic process (GO:0042304)2.44481662
162modulation by virus of host morphology or physiology (GO:0019048)2.39722161
163response to laminar fluid shear stress (GO:0034616)2.38977441
164positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.38409475
165cell volume homeostasis (GO:0006884)2.37766901
166urea metabolic process (GO:0019627)2.37284071
167ribosomal small subunit biogenesis (GO:0042274)2.36340029
168retrograde transport, endosome to Golgi (GO:0042147)2.36163575
169cholesterol efflux (GO:0033344)2.35761097
170virion attachment to host cell (GO:0019062)2.35614077
171adhesion of symbiont to host cell (GO:0044650)2.35614077
172positive regulation of protein dephosphorylation (GO:0035307)2.33899215
173UV protection (GO:0009650)2.33636150
174histone H4 deacetylation (GO:0070933)2.32825553
175protein targeting to plasma membrane (GO:0072661)2.30995345
176activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30917857
177regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29236220
178positive regulation of lipid catabolic process (GO:0050996)2.28785759
179positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.28042658
180positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.27758288
181nitrogen cycle metabolic process (GO:0071941)2.27480533
182protein-lipid complex remodeling (GO:0034368)2.27285845
183macromolecular complex remodeling (GO:0034367)2.27285845
184plasma lipoprotein particle remodeling (GO:0034369)2.27285845
1854-hydroxyproline metabolic process (GO:0019471)2.26745633
186hyaluronan catabolic process (GO:0030214)2.25931108
187maternal placenta development (GO:0001893)2.25444421
188positive regulation of triglyceride metabolic process (GO:0090208)2.25154335
189negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24000179
190protein-lipid complex subunit organization (GO:0071825)2.23210433

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.51852292
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.13356902
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.09889384
4ERG_21242973_ChIP-ChIP_JURKAT_Human3.05456750
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.96348219
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.95733512
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.94910136
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.64009942
9* LXR_22292898_ChIP-Seq_THP-1_Human2.62358240
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48767841
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.38464681
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.38464681
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.38464681
14SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.28795948
15ZFP281_18757296_ChIP-ChIP_E14_Mouse2.28452224
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.25086945
17VDR_21846776_ChIP-Seq_THP-1_Human2.17761864
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17481005
19RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15230746
20* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14573604
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02591808
22NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.02453716
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.01788614
24* POU5F1_16518401_ChIP-PET_MESCs_Mouse2.01772770
25* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.90225095
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89660289
27TCF7_22412390_ChIP-Seq_EML_Mouse1.87214991
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86961446
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.86516089
30RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84650555
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.82435347
32ZNF263_19887448_ChIP-Seq_K562_Human1.80120295
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.72494339
34ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.70577339
35CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70460996
36* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.69706197
37KDM2B_26808549_Chip-Seq_K562_Human1.69313503
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69209742
39KDM2B_26808549_Chip-Seq_DND41_Human1.68456813
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.64103077
41RACK7_27058665_Chip-Seq_MCF-7_Human1.63488053
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58437858
43ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.57878666
44PU.1_20513432_ChIP-Seq_Bcells_Mouse1.56973452
45* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56018357
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55592814
47NANOG_21062744_ChIP-ChIP_HESCs_Human1.53873691
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.52595592
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.52202977
50NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51920689
51REST_18959480_ChIP-ChIP_MESCs_Mouse1.50191086
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.49775699
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48281490
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46875165
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.46075432
56CTCF_27219007_Chip-Seq_Bcells_Human1.45980562
57PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44615200
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44550055
59* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43914269
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43167764
61VDR_24763502_ChIP-Seq_THP-1_Human1.42306999
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42039375
63ELF1_20517297_ChIP-Seq_JURKAT_Human1.41820647
64* REST_21632747_ChIP-Seq_MESCs_Mouse1.40466939
65MYC_22102868_ChIP-Seq_BL_Human1.40233214
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39604425
67TET1_21490601_ChIP-Seq_MESCs_Mouse1.38854542
68KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38449949
69SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.37567960
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37404517
71CTCF_21964334_ChIP-Seq_BJAB-B_Human1.36619906
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.35802251
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35110064
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34647159
75CLOCK_20551151_ChIP-Seq_293T_Human1.34094585
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33409160
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.33233841
78P68_20966046_ChIP-Seq_HELA_Human1.31563310
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30688769
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30260802
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.30106909
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29931108
83* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.29287798
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29053504
85DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27442752
86BCL6_27268052_Chip-Seq_Bcells_Human1.26412308
87TRIM28_21343339_ChIP-Seq_HEK293_Human1.26310673
88SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.26054733
89ETS1_21867929_ChIP-Seq_TH2_Mouse1.25774086
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25699557
91SA1_27219007_Chip-Seq_ERYTHROID_Human1.25288290
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.25234115
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.25217355
94MAF_26560356_Chip-Seq_TH2_Human1.24444836
95CREB1_26743006_Chip-Seq_LNCaP_Human1.24256605
96KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23585879
97TP53_22127205_ChIP-Seq_IMR90_Human1.23483467
98SMC4_20622854_ChIP-Seq_HELA_Human1.23179973
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22298175
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22231563
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21822402
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.21000036
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20798547
104PHF8_20622854_ChIP-Seq_HELA_Human1.20635211
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20494696
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19756002
107* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19020607
108STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19008821
109E2F1_20622854_ChIP-Seq_HELA_Human1.18782461
110FOXP1_21924763_ChIP-Seq_HESCs_Human1.18256169
111NCOR1_26117541_ChIP-Seq_K562_Human1.18088068
112BCOR_27268052_Chip-Seq_Bcells_Human1.17611419
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16970080
114ATF3_27146783_Chip-Seq_COLON_Human1.16229233
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15429400
116MAF_26560356_Chip-Seq_TH1_Human1.15409008
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15170324
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15099487
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14708266
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14501894
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13560584
122KDM2B_26808549_Chip-Seq_JURKAT_Human1.13337724
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13003605
124RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12737572
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11475317
126SA1_27219007_Chip-Seq_Bcells_Human1.11152812
127CTCF_26484167_Chip-Seq_Bcells_Mouse1.10749414
128RUNX1_22412390_ChIP-Seq_EML_Mouse1.10639457
129NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10635280
130MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10567855
131* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10452841
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10402620
133GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09950545
134ELK3_25401928_ChIP-Seq_HUVEC_Human1.09890470
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09275251
136* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08971330
137SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08727659
138UTX_26944678_Chip-Seq_JUKART_Human1.08520714
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08195573
140SPI1_26923725_Chip-Seq_HPCs_Mouse1.08131085
141SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.07884235
142TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07453005
143NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06238477
144* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05715730
145SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04761266
146BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03542296
147SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03302207
148GATA1_19941827_ChIP-Seq_MEL_Mouse1.03294864
149* TP63_22573176_ChIP-Seq_HFKS_Human1.02819531
150STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.02380075
151* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99867162
152* RARA_24833708_ChIP-Seq_LIVER_Mouse0.98933331
153CTCF_21964334_Chip-Seq_Bcells_Human0.98750132
154RUNX1_27514584_Chip-Seq_MCF-7_Human0.95547428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.48594458
2MP0008057_abnormal_DNA_replication4.01119302
3MP0004859_abnormal_synaptic_plasticity3.99753852
4MP0009278_abnormal_bone_marrow3.72207064
5MP0004233_abnormal_muscle_weight3.69097272
6MP0005171_absent_coat_pigmentation3.65212222
7MP0008438_abnormal_cutaneous_collagen3.58967658
8MP0009840_abnormal_foam_cell3.41918508
9MP0005451_abnormal_body_composition3.23155283
10MP0010030_abnormal_orbit_morphology3.15444209
11MP0003283_abnormal_digestive_organ2.99237243
12MP0005360_urolithiasis2.90091552
13MP0002653_abnormal_ependyma_morphology2.53280142
14MP0008995_early_reproductive_senescence2.43825497
15MP0003191_abnormal_cellular_cholesterol2.39998470
16MP0003279_aneurysm2.39771238
17MP0004510_myositis2.34708635
18MP0003635_abnormal_synaptic_transmissio2.27242374
19MP0006072_abnormal_retinal_apoptosis2.25516022
20MP0003119_abnormal_digestive_system2.17098995
21MP0004133_heterotaxia2.16938612
22MP0001849_ear_inflammation2.13972156
23MP0002063_abnormal_learning/memory/cond2.12134759
24MP0008260_abnormal_autophagy2.11566082
25MP0003436_decreased_susceptibility_to2.06729030
26MP0009046_muscle_twitch2.06665847
27MP0001958_emphysema2.03810732
28MP0002009_preneoplasia2.02387599
29MP0003172_abnormal_lysosome_physiology1.99256625
30MP0004185_abnormal_adipocyte_glucose1.98680726
31MP0002572_abnormal_emotion/affect_behav1.88098362
32MP0009384_cardiac_valve_regurgitation1.87450359
33MP0002064_seizures1.86078578
34MP0003566_abnormal_cell_adhesion1.79755870
35MP0003890_abnormal_embryonic-extraembry1.78322194
36MP0000678_abnormal_parathyroid_gland1.72039446
37MP0004272_abnormal_basement_membrane1.71784333
38MP0002733_abnormal_thermal_nociception1.71382294
39MP0005257_abnormal_intraocular_pressure1.71244759
40MP0003880_abnormal_central_pattern1.65792662
41MP0005666_abnormal_adipose_tissue1.64641990
42MP0002249_abnormal_larynx_morphology1.64136977
43MP0003303_peritoneal_inflammation1.63899622
44MP0003879_abnormal_hair_cell1.59836308
45MP0004142_abnormal_muscle_tone1.59668100
46MP0005174_abnormal_tail_pigmentation1.59658104
47MP0005375_adipose_tissue_phenotype1.59213281
48MP0000003_abnormal_adipose_tissue1.58755983
49MP0005397_hematopoietic_system_phenotyp1.58290096
50MP0001545_abnormal_hematopoietic_system1.58290096
51MP0001970_abnormal_pain_threshold1.56228070
52MP0000579_abnormal_nail_morphology1.55177112
53MP0000955_abnormal_spinal_cord1.53713817
54MP0003137_abnormal_impulse_conducting1.50909788
55MP0000858_altered_metastatic_potential1.50690968
56MP0002139_abnormal_hepatobiliary_system1.49511573
57MP0005645_abnormal_hypothalamus_physiol1.46811009
58MP0000778_abnormal_nervous_system1.46241434
59MP0002269_muscular_atrophy1.43840431
60MP0002282_abnormal_trachea_morphology1.35397447
61MP0004811_abnormal_neuron_physiology1.35181862
62MP0000767_abnormal_smooth_muscle1.34747087
63MP0000566_synostosis1.32011414
64MP0005503_abnormal_tendon_morphology1.31322392
65MP0004270_analgesia1.30614848
66MP0009745_abnormal_behavioral_response1.30505682
67MP0000604_amyloidosis1.29728035
68MP0005023_abnormal_wound_healing1.27491532
69MP0000462_abnormal_digestive_system1.27043805
70MP0005409_darkened_coat_color1.25094262
71MP0005670_abnormal_white_adipose1.24324531
72MP0001293_anophthalmia1.23933702
73MP0002933_joint_inflammation1.23065555
74MP0002084_abnormal_developmental_patter1.21292337
75MP0003786_premature_aging1.19302238
76MP0003091_abnormal_cell_migration1.18510308
77MP0001533_abnormal_skeleton_physiology1.18463493
78MP0002184_abnormal_innervation1.18235517
79MP0000681_abnormal_thyroid_gland1.17520891
80MP0002998_abnormal_bone_remodeling1.17484902
81MP0000639_abnormal_adrenal_gland1.17263208
82MP0000751_myopathy1.14135955
83MP0001502_abnormal_circadian_rhythm1.13728294
84MP0002066_abnormal_motor_capabilities/c1.13008404
85MP0005508_abnormal_skeleton_morphology1.09964713
86MP0002272_abnormal_nervous_system1.09698492
87MP0008877_abnormal_DNA_methylation1.08722566
88MP0005464_abnormal_platelet_physiology1.07815652
89MP0001915_intracranial_hemorrhage1.07273240
90MP0010094_abnormal_chromosome_stability1.06841447
91MP0004947_skin_inflammation1.06735073
92MP0009333_abnormal_splenocyte_physiolog1.06356367
93MP0001348_abnormal_lacrimal_gland1.06113482
94MP0002085_abnormal_embryonic_tissue1.05808697
95MP0001697_abnormal_embryo_size1.05784964
96MP0002086_abnormal_extraembryonic_tissu1.05543664
97MP0005390_skeleton_phenotype1.03997708
98MP0008569_lethality_at_weaning1.03685465
99MP0000733_abnormal_muscle_development1.03251930
100MP0002060_abnormal_skin_morphology1.01224053
101MP0001440_abnormal_grooming_behavior1.01184139
102MP0005076_abnormal_cell_differentiation1.00906896
103MP0002152_abnormal_brain_morphology1.00545186
104MP0002882_abnormal_neuron_morphology1.00159104
105MP0002796_impaired_skin_barrier0.99999438
106MP0002067_abnormal_sensory_capabilities0.99897581
107MP0001340_abnormal_eyelid_morphology0.99058221
108MP0004885_abnormal_endolymph0.98473571
109MP0003453_abnormal_keratinocyte_physiol0.97747028
110MP0003300_gastrointestinal_ulcer0.97547813
111MP0003123_paternal_imprinting0.95394934
112MP0002132_abnormal_respiratory_system0.94342880
113MP0003656_abnormal_erythrocyte_physiolo0.93982081
114MP0005058_abnormal_lysosome_morphology0.93000109
115MP0000759_abnormal_skeletal_muscle0.92740581
116MP0000015_abnormal_ear_pigmentation0.92104641
117MP0000371_diluted_coat_color0.91813063
118MP0004197_abnormal_fetal_growth/weight/0.91719130
119MP0002254_reproductive_system_inflammat0.91255959
120MP0003861_abnormal_nervous_system0.90531092
121MP0003633_abnormal_nervous_system0.90269251
122MP0000470_abnormal_stomach_morphology0.89642474
123MP0010329_abnormal_lipoprotein_level0.89313822
124MP0010368_abnormal_lymphatic_system0.89308011
125MP0005386_behavior/neurological_phenoty0.88755895
126MP0004924_abnormal_behavior0.88755895
127MP0004957_abnormal_blastocyst_morpholog0.87758446
128MP0005423_abnormal_somatic_nervous0.87498592
129MP0002971_abnormal_brown_adipose0.85213332
130MP0005275_abnormal_skin_tensile0.84869160
131MP0005075_abnormal_melanosome_morpholog0.84850590
132MP0010768_mortality/aging0.84590879
133MP0003075_altered_response_to0.84192179
134MP0004130_abnormal_muscle_cell0.81219004
135MP0010769_abnormal_survival0.81024705
136MP0002419_abnormal_innate_immunity0.80861130
137MP0005365_abnormal_bile_salt0.79789644
138MP0003567_abnormal_fetal_cardiomyocyte0.79357896
139MP0002822_catalepsy0.79260596
140MP0002089_abnormal_postnatal_growth/wei0.79108562
141MP0000747_muscle_weakness0.78008326
142MP0003942_abnormal_urinary_system0.77991375
143MP0003329_amyloid_beta_deposits0.77911025
144MP0005501_abnormal_skin_physiology0.77655867
145MP0001873_stomach_inflammation0.76796851
146MP0005623_abnormal_meninges_morphology0.76298325
147MP0002896_abnormal_bone_mineralization0.76296417
148MP0002932_abnormal_joint_morphology0.76163569
149MP0002114_abnormal_axial_skeleton0.75480246
150MP0002082_postnatal_lethality0.72916435
151MP0010770_preweaning_lethality0.72916435
152MP0003111_abnormal_nucleus_morphology0.72880681
153MP0004858_abnormal_nervous_system0.72275057
154MP0005266_abnormal_metabolism0.71183885
155MP0002734_abnormal_mechanical_nocicepti0.70775312
156MP0008874_decreased_physiological_sensi0.70728321
157MP0002111_abnormal_tail_morphology0.69888568
158MP0005025_abnormal_response_to0.69662343
159MP0008932_abnormal_embryonic_tissue0.69558959
160MP0001486_abnormal_startle_reflex0.69009609
161MP0005380_embryogenesis_phenotype0.68370394
162MP0001672_abnormal_embryogenesis/_devel0.68370394
163MP0006082_CNS_inflammation0.68285654
164MP0002113_abnormal_skeleton_development0.67781368
165MP0009931_abnormal_skin_appearance0.67387775
166MP0001968_abnormal_touch/_nociception0.66924487
167MP0003634_abnormal_glial_cell0.66766360
168MP0000013_abnormal_adipose_tissue0.66459166
169MP0009379_abnormal_foot_pigmentation0.66114592
170MP0002877_abnormal_melanocyte_morpholog0.64820255
171MP0002118_abnormal_lipid_homeostasis0.64638634
172MP0000343_altered_response_to0.63995214
173MP0002970_abnormal_white_adipose0.63844451
174MP0000609_abnormal_liver_physiology0.63501468
175MP0004087_abnormal_muscle_fiber0.62410960
176MP0004381_abnormal_hair_follicle0.61734809
177MP0006138_congestive_heart_failure0.61514785
178MP0001614_abnormal_blood_vessel0.60539530
179MP0002108_abnormal_muscle_morphology0.60308132
180MP0003795_abnormal_bone_structure0.60272569
181MP0001851_eye_inflammation0.59637675

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)5.70061049
2Concave nail (HP:0001598)5.11100004
3Turricephaly (HP:0000262)4.67858749
4Facial hemangioma (HP:0000329)4.56249763
5Protrusio acetabuli (HP:0003179)4.52584301
6Rib fusion (HP:0000902)4.44963970
7Deep venous thrombosis (HP:0002625)3.98849371
8Pustule (HP:0200039)3.96639113
9Premature rupture of membranes (HP:0001788)3.86251972
10Abnormality of the lower motor neuron (HP:0002366)3.86144174
11Rectal fistula (HP:0100590)3.81354857
12Rectovaginal fistula (HP:0000143)3.81354857
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.75589418
14Myokymia (HP:0002411)3.74455797
15Alopecia of scalp (HP:0002293)3.71423466
16Poikiloderma (HP:0001029)3.70453830
17Increased IgM level (HP:0003496)3.69007586
18Coronal craniosynostosis (HP:0004440)3.53927508
19Short chin (HP:0000331)3.48170211
20Anteriorly placed anus (HP:0001545)3.46664725
21Intestinal fistula (HP:0100819)3.41108071
22Vaginal fistula (HP:0004320)3.38655455
23Male infertility (HP:0003251)3.38424254
24Tongue fasciculations (HP:0001308)3.37586245
25Ulnar bowing (HP:0003031)3.30479449
26Orthostatic hypotension (HP:0001278)3.29380512
27Hypochromic microcytic anemia (HP:0004840)3.23599267
28Vertebral compression fractures (HP:0002953)3.23120454
29Congenital hip dislocation (HP:0001374)3.22149380
30Abnormality of the aortic arch (HP:0012303)3.21518048
31Alacrima (HP:0000522)3.16798909
32Muscle fibrillation (HP:0010546)3.09779764
33Cervical subluxation (HP:0003308)2.97325757
34Short humerus (HP:0005792)2.96744445
35Growth hormone excess (HP:0000845)2.94979347
36Large for gestational age (HP:0001520)2.94945559
37Dysautonomia (HP:0002459)2.90868301
38Visual hallucinations (HP:0002367)2.88386970
39Aplasia/hypoplasia of the humerus (HP:0006507)2.87030485
40Achilles tendon contracture (HP:0001771)2.86391879
41Abnormality of the Achilles tendon (HP:0005109)2.83629406
42Broad alveolar ridges (HP:0000187)2.81512258
43Mucopolysacchariduria (HP:0008155)2.78099193
44Urinary glycosaminoglycan excretion (HP:0003541)2.78099193
45Biconcave vertebral bodies (HP:0004586)2.76388869
46Choanal stenosis (HP:0000452)2.73690023
47Atonic seizures (HP:0010819)2.73599807
48Diaphragmatic weakness (HP:0009113)2.72312941
49Round ear (HP:0100830)2.69152122
50Systemic lupus erythematosus (HP:0002725)2.68294347
51Narrow nasal bridge (HP:0000446)2.65761922
52Abnormality of complement system (HP:0005339)2.62926254
53Focal motor seizures (HP:0011153)2.62802080
54Increased connective tissue (HP:0009025)2.61818010
55Dysostosis multiplex (HP:0000943)2.60980747
56Clumsiness (HP:0002312)2.60410890
57Abnormality of polysaccharide metabolism (HP:0011012)2.58968333
58Abnormality of glycosaminoglycan metabolism (HP:0004371)2.58968333
59Abnormality of mucopolysaccharide metabolism (HP:0011020)2.58968333
60Increased variability in muscle fiber diameter (HP:0003557)2.58138900
61Hypotrichosis (HP:0001006)2.57658001
62Intestinal atresia (HP:0011100)2.55333743
63J-shaped sella turcica (HP:0002680)2.55041079
64Premature skin wrinkling (HP:0100678)2.54488189
65Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.54370250
66Vertebral hypoplasia (HP:0008417)2.54370250
67Hemorrhage of the eye (HP:0011885)2.53541567
68Hamartoma (HP:0010566)2.52619003
69Polycythemia (HP:0001901)2.49843096
70Shallow orbits (HP:0000586)2.47953412
71Absence seizures (HP:0002121)2.47624305
72Distal upper limb amyotrophy (HP:0007149)2.47480212
73Upper limb amyotrophy (HP:0009129)2.47480212
74Stridor (HP:0010307)2.43998711
75Absent radius (HP:0003974)2.43105436
76Fragile skin (HP:0001030)2.42637601
77Disproportionate tall stature (HP:0001519)2.41252718
78Spinal muscular atrophy (HP:0007269)2.41126004
79Spinal rigidity (HP:0003306)2.41106201
80Albinism (HP:0001022)2.40590842
81Abnormality of the astrocytes (HP:0100707)2.39877024
82Astrocytoma (HP:0009592)2.39877024
83Hypercortisolism (HP:0001578)2.38411286
84Complement deficiency (HP:0004431)2.37709695
85Abnormality of male internal genitalia (HP:0000022)2.36453457
86Decreased lacrimation (HP:0000633)2.36412986
87Joint stiffness (HP:0001387)2.36338733
88Metaphyseal cupping (HP:0003021)2.36281832
89Febrile seizures (HP:0002373)2.35826390
90Thin bony cortex (HP:0002753)2.35479439
91Aplasia involving forearm bones (HP:0009822)2.33960078
92Absent forearm bone (HP:0003953)2.33960078
93Abnormality of the labia minora (HP:0012880)2.33138052
94Distal lower limb amyotrophy (HP:0008944)2.32710448
95Hyperacusis (HP:0010780)2.32667631
96Blue sclerae (HP:0000592)2.32588749
97Epileptic encephalopathy (HP:0200134)2.32045621
98Basal cell carcinoma (HP:0002671)2.30424432
99Broad face (HP:0000283)2.29243524
100Mitral regurgitation (HP:0001653)2.29028904
101Fetal akinesia sequence (HP:0001989)2.27225982
102Nuclear cataract (HP:0100018)2.26535161
103Xanthomatosis (HP:0000991)2.26085964
104Acute lymphatic leukemia (HP:0006721)2.25534557
105Cupped ribs (HP:0000887)2.24496882
106Focal seizures (HP:0007359)2.23410078
107Abnormal hemoglobin (HP:0011902)2.20833639
108Abnormality of skeletal muscle fiber size (HP:0012084)2.20533715
109Myopathic facies (HP:0002058)2.19650132
110Distal lower limb muscle weakness (HP:0009053)2.18833764
111Aplasia of the musculature (HP:0100854)2.18004627
112Squamous cell carcinoma (HP:0002860)2.16799588
113Obstructive sleep apnea (HP:0002870)2.16147770
114Patellar aplasia (HP:0006443)2.14556523
115Hypokinesia (HP:0002375)2.14320274
116Type 1 muscle fiber predominance (HP:0003803)2.12850991
117Purpura (HP:0000979)2.12202257
118Atrophic scars (HP:0001075)2.12087241
119Coxa vara (HP:0002812)2.11275519
120Split hand (HP:0001171)2.10913673
121Hypotelorism (HP:0000601)2.10435278
122Bifid uvula (HP:0000193)2.09794440
123Dialeptic seizures (HP:0011146)2.08809841
124Axonal loss (HP:0003447)2.07296594
125Mildly elevated creatine phosphokinase (HP:0008180)2.07253221
126Pancreatic islet-cell hyperplasia (HP:0004510)2.05798405
127Abnormality of liposaccharide metabolism (HP:0010968)2.01344674
128Abnormality of glycosphingolipid metabolism (HP:0004343)2.01344674
129Abnormality of glycolipid metabolism (HP:0010969)2.01344674
130Bowed forearm bones (HP:0003956)2.01019597
131Bowing of the arm (HP:0006488)2.01019597
132Amelogenesis imperfecta (HP:0000705)2.00616483
133Absent thumb (HP:0009777)2.00567373
134Dysdiadochokinesis (HP:0002075)1.99241070
135Diminished movement (HP:0002374)1.99225922
136Hypertriglyceridemia (HP:0002155)1.98994574
137Cerebral aneurysm (HP:0004944)1.98139984
138Flat acetabular roof (HP:0003180)1.97098412
139Aplasia/Hypoplasia of the patella (HP:0006498)1.97007784
140Aneurysm (HP:0002617)1.96517116
141Lymphangioma (HP:0100764)1.95742799
142Ankle contracture (HP:0006466)1.94995502
143Bladder diverticulum (HP:0000015)1.94445972
144Thickened helices (HP:0000391)1.93956693
145Joint hemorrhage (HP:0005261)1.93413371
146Bulbar palsy (HP:0001283)1.89916853
147Dilatation of the ascending aorta (HP:0005111)1.89800320
148Neurofibrillary tangles (HP:0002185)1.87687502
149Abnormality of the periventricular white matter (HP:0002518)1.87546048
150Centrally nucleated skeletal muscle fibers (HP:0003687)1.87074032
151Genu recurvatum (HP:0002816)1.87044588
152Abnormality of dentin (HP:0010299)1.85571943
153Abnormality of the thoracic spine (HP:0100711)1.85270262
154Wormian bones (HP:0002645)1.84959228
155Capillary hemangiomas (HP:0005306)1.84746382
156Asymmetric septal hypertrophy (HP:0001670)1.84601210
157Abnormal gallbladder physiology (HP:0012438)1.84059999
158Cholecystitis (HP:0001082)1.84059999
159Difficulty climbing stairs (HP:0003551)1.83516964
160Generalized amyotrophy (HP:0003700)1.83288994
161Failure to thrive in infancy (HP:0001531)1.82846697
162Exercise-induced myalgia (HP:0003738)1.81994388
163Abnormality of monocarboxylic acid metabolism (HP:0010996)1.81595861
164Tented upper lip vermilion (HP:0010804)1.79932622
165Easy fatigability (HP:0003388)1.79458265
166Broad metatarsal (HP:0001783)1.78263421
167Short nail (HP:0001799)1.76793503
168Hand muscle atrophy (HP:0009130)1.76553056
169Elbow flexion contracture (HP:0002987)1.75594304
170Polygenic inheritance (HP:0010982)1.75429562
171Peritonitis (HP:0002586)1.75361678
172Hyperextensible skin (HP:0000974)1.74483230
173Aortic aneurysm (HP:0004942)1.73459833
174Supranuclear gaze palsy (HP:0000605)1.73382707
175Emphysema (HP:0002097)1.72709901
176Cerebral inclusion bodies (HP:0100314)1.71998125
177Slender build (HP:0001533)1.71958689
178Vascular tortuosity (HP:0004948)1.70771841
179Broad distal phalanx of finger (HP:0009836)1.70107241
180Reticulocytosis (HP:0001923)1.70064523
181Neonatal short-limb short stature (HP:0008921)1.70023877
182Flared iliac wings (HP:0002869)1.69866389
183Atelectasis (HP:0100750)1.68537147
184Ovoid vertebral bodies (HP:0003300)1.67564865
185Long palpebral fissure (HP:0000637)1.66434961
186Glomerulonephritis (HP:0000099)1.65918115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.63039292
2DDR24.44692662
3MAPK154.34456221
4MAP3K64.31611879
5ERN13.52696392
6TYRO33.34202086
7PINK13.32665188
8SIK13.26245288
9MAP3K113.23378253
10DAPK12.79817490
11UHMK12.68336062
12FGR2.59810088
13SMG12.59189609
14MATK2.51888788
15MAP3K92.33745474
16MAP2K32.22614646
17IRAK32.15119498
18PRKD22.09500015
19NME21.99175505
20FGFR41.98520219
21EEF2K1.86713266
22BMX1.82534574
23LATS21.79048735
24PDGFRA1.75576191
25TTN1.70971613
26PHKG21.62733840
27PHKG11.62733840
28DYRK1B1.60593923
29PKN21.58221380
30CSK1.56243207
31TESK11.51085633
32EPHA21.50184641
33YES11.48084666
34PIM21.48010526
35ARAF1.42483289
36EPHA41.37764820
37AKT31.37329983
38MARK11.34073721
39CDK121.31968235
40MAP3K31.27189084
41PAK61.26673294
42CDC42BPA1.19007729
43MAP3K131.18463652
44MAP4K11.18051783
45NTRK31.17311756
46PRPF4B1.15504244
47NTRK21.13771635
48CDK71.10988403
49PTK61.10433269
50TBK11.06643757
51PDPK11.06365595
52TAOK11.03382649
53EPHB11.03158929
54BRAF0.97764943
55MAP3K100.97732507
56RPS6KC10.97521501
57RPS6KL10.97521501
58TESK20.95122719
59MAP3K10.94309475
60TYK20.93935248
61PAK40.92439358
62RPS6KA20.91876197
63ZAP700.91333109
64MAPK110.91173163
65MAP3K70.90009394
66TRIB30.89297110
67IRAK20.87760874
68TAOK20.83288662
69IRAK40.82434026
70SIK20.81708759
71STK380.80547319
72RPS6KA60.80082491
73MINK10.79906902
74RAF10.77553586
75GSK3A0.77083424
76MAP2K60.76137067
77CDK60.75736824
78MAPK120.72901310
79PRKAA10.72099471
80ABL20.71979708
81RIPK40.71969092
82GRK60.71944204
83MST1R0.71942930
84LRRK20.69745203
85CHEK20.69638515
86MAP3K40.69122544
87EPHB20.66985558
88RET0.66950068
89FES0.66738967
90DYRK20.63749247
91PRKG20.63242426
92MAP2K20.62683688
93RPS6KA10.61912369
94CDK150.61642067
95CDK50.61234298
96CDK11A0.60747272
97NEK10.60419753
98CAMK2B0.60397887
99RIPK10.60333001
100CDK180.58956950
101DYRK30.58676442
102PIM10.57841690
103DAPK20.57766745
104PDK10.57479137
105TRPM70.56233538
106KSR20.56077875
107MARK20.56008118
108MTOR0.53526663
109ILK0.53150551
110PRKD30.52763906
111LMTK20.52655805
112MOS0.52593177
113KIT0.52117630
114CDK140.51789710
115HIPK20.50468565
116CDK190.50448781
117ALK0.50394293
118CAMK2G0.49968796
119JAK30.49648170
120CAMK2A0.48039322
121PRKCZ0.46292241
122PLK10.42408403
123FGFR30.41555001
124MAPK70.41545723
125SIK30.41052494
126MAPK100.40663128
127MAP3K80.39564996
128KDR0.39562326
129RPS6KB10.39183003
130MAPKAPK30.37264184
131TNK20.37128578
132CDK20.36474257
133NTRK10.35881689
134KSR10.35867030
135MAPK40.35387127
136DAPK30.34162337
137CAMKK10.33149555
138SGK10.32847550
139PRKD10.32622369
140RPS6KA30.32334114
141PTK20.31808904
142MET0.31444857
143CAMK2D0.30497143
144CSNK1G10.29972295
145MAPKAPK20.28394188
146ERBB30.28255647
147EGFR0.26591144
148AURKA0.24404447
149MAP2K40.23104455
150MAPK90.22737901
151PRKCG0.21897940
152STK110.21840283
153MAPK140.21551091
154CSNK1E0.21435622
155PDGFRB0.20926754
156PAK20.20639623
157GSK3B0.20634379
158MAPK10.20621608
159PRKCI0.20370932

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.93313943
2Other glycan degradation_Homo sapiens_hsa005114.26551633
3Base excision repair_Homo sapiens_hsa034103.16862822
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.92760015
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.80705005
6Mismatch repair_Homo sapiens_hsa034302.75578428
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.68412475
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.51541125
9Circadian rhythm_Homo sapiens_hsa047102.39853870
10mTOR signaling pathway_Homo sapiens_hsa041502.31192430
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.10135134
12Nicotine addiction_Homo sapiens_hsa050332.07046317
13Prion diseases_Homo sapiens_hsa050202.00827295
14Complement and coagulation cascades_Homo sapiens_hsa046101.92828586
15Synaptic vesicle cycle_Homo sapiens_hsa047211.90455369
16Hedgehog signaling pathway_Homo sapiens_hsa043401.88208112
17DNA replication_Homo sapiens_hsa030301.75375947
18Sulfur relay system_Homo sapiens_hsa041221.71467567
19Hippo signaling pathway_Homo sapiens_hsa043901.67266310
20Biosynthesis of amino acids_Homo sapiens_hsa012301.62419147
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61755765
22Longevity regulating pathway - mammal_Homo sapiens_hsa042111.61355997
23GABAergic synapse_Homo sapiens_hsa047271.60797362
24Arginine and proline metabolism_Homo sapiens_hsa003301.59003885
25Chronic myeloid leukemia_Homo sapiens_hsa052201.58039958
26VEGF signaling pathway_Homo sapiens_hsa043701.48890337
27Lysosome_Homo sapiens_hsa041421.46387451
28Gap junction_Homo sapiens_hsa045401.45963291
29mRNA surveillance pathway_Homo sapiens_hsa030151.44421861
30Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44040449
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43105623
32Oocyte meiosis_Homo sapiens_hsa041141.42688278
33Non-small cell lung cancer_Homo sapiens_hsa052231.37784361
34Pentose phosphate pathway_Homo sapiens_hsa000301.31024446
35Amphetamine addiction_Homo sapiens_hsa050311.30780690
36Olfactory transduction_Homo sapiens_hsa047401.30146909
37Wnt signaling pathway_Homo sapiens_hsa043101.27808962
38Glutamatergic synapse_Homo sapiens_hsa047241.26000370
39Long-term potentiation_Homo sapiens_hsa047201.20391607
40Fructose and mannose metabolism_Homo sapiens_hsa000511.20223497
41ECM-receptor interaction_Homo sapiens_hsa045121.17445481
42ErbB signaling pathway_Homo sapiens_hsa040121.15090487
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.14268190
44Focal adhesion_Homo sapiens_hsa045101.13833664
45Dopaminergic synapse_Homo sapiens_hsa047281.13762396
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13422173
47Vitamin B6 metabolism_Homo sapiens_hsa007501.13385735
48Long-term depression_Homo sapiens_hsa047301.11040865
49Amoebiasis_Homo sapiens_hsa051461.10861080
50Choline metabolism in cancer_Homo sapiens_hsa052311.10349046
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.09993155
52Fatty acid metabolism_Homo sapiens_hsa012121.09790941
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09752562
54Bladder cancer_Homo sapiens_hsa052191.09204802
55Phenylalanine metabolism_Homo sapiens_hsa003601.07669217
56Adipocytokine signaling pathway_Homo sapiens_hsa049201.07627725
57Circadian entrainment_Homo sapiens_hsa047131.07611650
58GnRH signaling pathway_Homo sapiens_hsa049121.06161362
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05417695
60RNA transport_Homo sapiens_hsa030131.02695163
61Osteoclast differentiation_Homo sapiens_hsa043801.02321523
62Arginine biosynthesis_Homo sapiens_hsa002201.00591144
63Spliceosome_Homo sapiens_hsa030400.99688435
64Morphine addiction_Homo sapiens_hsa050320.99679397
65Pancreatic cancer_Homo sapiens_hsa052120.98325809
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95534389
67* Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95266856
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94817608
69Colorectal cancer_Homo sapiens_hsa052100.94031795
70Staphylococcus aureus infection_Homo sapiens_hsa051500.93716839
71Basal cell carcinoma_Homo sapiens_hsa052170.91925255
72Adherens junction_Homo sapiens_hsa045200.91428146
73Nucleotide excision repair_Homo sapiens_hsa034200.91043054
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.89650692
75PPAR signaling pathway_Homo sapiens_hsa033200.88742580
76Folate biosynthesis_Homo sapiens_hsa007900.88485221
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.87989377
78Pertussis_Homo sapiens_hsa051330.87304308
79Insulin resistance_Homo sapiens_hsa049310.86491978
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86312331
81Vibrio cholerae infection_Homo sapiens_hsa051100.84691082
82Dorso-ventral axis formation_Homo sapiens_hsa043200.84528712
83B cell receptor signaling pathway_Homo sapiens_hsa046620.83096020
84Estrogen signaling pathway_Homo sapiens_hsa049150.81860480
85Insulin signaling pathway_Homo sapiens_hsa049100.81256429
86Shigellosis_Homo sapiens_hsa051310.81140000
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79099275
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77484032
89Oxytocin signaling pathway_Homo sapiens_hsa049210.75146368
90Proteoglycans in cancer_Homo sapiens_hsa052050.75078253
91Salivary secretion_Homo sapiens_hsa049700.74174312
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74038378
93Hepatitis C_Homo sapiens_hsa051600.73191712
94Malaria_Homo sapiens_hsa051440.72580604
95Bile secretion_Homo sapiens_hsa049760.71905447
96* Notch signaling pathway_Homo sapiens_hsa043300.71569071
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71235596
98Small cell lung cancer_Homo sapiens_hsa052220.70451742
99Renal cell carcinoma_Homo sapiens_hsa052110.70231759
100Lysine degradation_Homo sapiens_hsa003100.69566935
101AMPK signaling pathway_Homo sapiens_hsa041520.68877970
102MAPK signaling pathway_Homo sapiens_hsa040100.67445310
103Insulin secretion_Homo sapiens_hsa049110.66363772
104Aldosterone synthesis and secretion_Homo sapiens_hsa049250.66089537
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.66025840
106Toxoplasmosis_Homo sapiens_hsa051450.65522744
107Glucagon signaling pathway_Homo sapiens_hsa049220.63902130
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63719178
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.63607227
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63524021
111Cardiac muscle contraction_Homo sapiens_hsa042600.62524942
112p53 signaling pathway_Homo sapiens_hsa041150.62435359
113Carbon metabolism_Homo sapiens_hsa012000.61288508
114Tight junction_Homo sapiens_hsa045300.59848995
115Endometrial cancer_Homo sapiens_hsa052130.59580130
116Salmonella infection_Homo sapiens_hsa051320.59320871
117TGF-beta signaling pathway_Homo sapiens_hsa043500.59117332
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57592617
119Prolactin signaling pathway_Homo sapiens_hsa049170.55883576
120TNF signaling pathway_Homo sapiens_hsa046680.55794447
121Leishmaniasis_Homo sapiens_hsa051400.55763221
122Gastric acid secretion_Homo sapiens_hsa049710.55687282
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55331082
124Tyrosine metabolism_Homo sapiens_hsa003500.55101963
125Galactose metabolism_Homo sapiens_hsa000520.54416098
126Melanogenesis_Homo sapiens_hsa049160.54355565
127Endocytosis_Homo sapiens_hsa041440.54139906
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.53877626
129Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52546019
130Taste transduction_Homo sapiens_hsa047420.52545524
131Cholinergic synapse_Homo sapiens_hsa047250.52527544
132Axon guidance_Homo sapiens_hsa043600.52060011
133Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50891696
134Cocaine addiction_Homo sapiens_hsa050300.50084175
135Glioma_Homo sapiens_hsa052140.49037592
136Calcium signaling pathway_Homo sapiens_hsa040200.47882225
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47296962
138Rap1 signaling pathway_Homo sapiens_hsa040150.46906596
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46773569
140HIF-1 signaling pathway_Homo sapiens_hsa040660.46616087
141N-Glycan biosynthesis_Homo sapiens_hsa005100.46501583
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46387342
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45727047
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45570261
145Tuberculosis_Homo sapiens_hsa051520.45474158
146Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44491702
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43964042
148Apoptosis_Homo sapiens_hsa042100.43530753
149Inositol phosphate metabolism_Homo sapiens_hsa005620.41490827
150Hepatitis B_Homo sapiens_hsa051610.41105252
151Prostate cancer_Homo sapiens_hsa052150.40434993
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40321960
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.38944105
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.36704113
155Thyroid cancer_Homo sapiens_hsa052160.36489281
156Serotonergic synapse_Homo sapiens_hsa047260.36389445
157Glycerolipid metabolism_Homo sapiens_hsa005610.36310011
158Acute myeloid leukemia_Homo sapiens_hsa052210.34487007
159Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33792508
160Sphingolipid signaling pathway_Homo sapiens_hsa040710.33528169

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