RFPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of mesoderm development (GO:2000380)9.76003680
2phospholipid scrambling (GO:0017121)9.43693468
3cell migration involved in gastrulation (GO:0042074)8.39090540
4endoderm formation (GO:0001706)7.42303599
5sequestering of extracellular ligand from receptor (GO:0035581)7.33793289
6negative regulation of activin receptor signaling pathway (GO:0032926)7.18977425
7signal transduction involved in regulation of gene expression (GO:0023019)6.49237364
8somite rostral/caudal axis specification (GO:0032525)5.74338797
9anterior/posterior axis specification (GO:0009948)5.38659949
10DNA replication-dependent nucleosome assembly (GO:0006335)5.34997399
11DNA replication-dependent nucleosome organization (GO:0034723)5.34997399
12primitive streak formation (GO:0090009)5.34864870
13regulation of activin receptor signaling pathway (GO:0032925)5.13886186
14gastrulation (GO:0007369)5.07321164
15cellular response to BMP stimulus (GO:0071773)4.34831834
16response to BMP (GO:0071772)4.34831834
17regulation of penile erection (GO:0060405)4.16461004
18positive regulation of gastrulation (GO:2000543)4.12074026
19L-serine transport (GO:0015825)4.06282781
20extracellular negative regulation of signal transduction (GO:1900116)4.00655498
21extracellular regulation of signal transduction (GO:1900115)4.00655498
22positive regulation of uterine smooth muscle contraction (GO:0070474)3.99318220
23proline transport (GO:0015824)3.79663940
24CENP-A containing nucleosome assembly (GO:0034080)3.74540326
25positive regulation of catecholamine secretion (GO:0033605)3.64579896
26nodal signaling pathway (GO:0038092)3.61443128
27multicellular organism reproduction (GO:0032504)3.58959710
28regulation of cardioblast differentiation (GO:0051890)3.57551895
29vitamin catabolic process (GO:0009111)3.57117220
30fat-soluble vitamin catabolic process (GO:0042363)3.57117220
31embryonic axis specification (GO:0000578)3.54970410
32serine transport (GO:0032329)3.50213832
33histone H3-K9 demethylation (GO:0033169)3.47921504
34regulation of gastrulation (GO:0010470)3.46999853
35chromatin remodeling at centromere (GO:0031055)3.42600642
36axis specification (GO:0009798)3.41632367
37oocyte development (GO:0048599)3.41469193
38glycine transport (GO:0015816)3.39770379
39embryonic foregut morphogenesis (GO:0048617)3.38812902
40negative regulation of cell fate specification (GO:0009996)3.37039265
41histone exchange (GO:0043486)3.31937656
42glycosphingolipid biosynthetic process (GO:0006688)3.22714764
43dorsal/ventral axis specification (GO:0009950)3.22201161
44female gonad development (GO:0008585)3.20985322
45male meiosis I (GO:0007141)3.20810298
46aggressive behavior (GO:0002118)3.17299545
47mesenchymal to epithelial transition (GO:0060231)3.17142385
48positive regulation of meiosis (GO:0045836)3.15783902
49regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.12930992
50positive regulation of cardiac muscle tissue development (GO:0055025)3.10814043
51organ formation (GO:0048645)3.07620817
52DNA deamination (GO:0045006)3.05744202
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.05158538
54positive regulation of meiotic cell cycle (GO:0051446)3.04454567
55muscle organ morphogenesis (GO:0048644)3.04368607
56embryonic pattern specification (GO:0009880)3.04033310
57regulation of collateral sprouting (GO:0048670)3.03923996
58interferon-gamma production (GO:0032609)3.03504317
59negative regulation of embryonic development (GO:0045992)3.01086260
60regulation of uterine smooth muscle contraction (GO:0070472)2.97908045
61uterus development (GO:0060065)2.95169593
62sleep (GO:0030431)2.94315448
63regulation of membrane lipid distribution (GO:0097035)2.91149749
64negative regulation of digestive system process (GO:0060457)2.88167489
65binding of sperm to zona pellucida (GO:0007339)2.85330648
66dorsal/ventral neural tube patterning (GO:0021904)2.85084161
67regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.84614532
68positive regulation of cardiac muscle cell proliferation (GO:0060045)2.83292339
69fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82222848
70SMAD protein signal transduction (GO:0060395)2.81147194
71positive regulation of muscle organ development (GO:0048636)2.80237887
72positive regulation of striated muscle tissue development (GO:0045844)2.80237887
73Rap protein signal transduction (GO:0032486)2.78497340
74negative regulation of reproductive process (GO:2000242)2.73331021
75positive regulation of muscle tissue development (GO:1901863)2.71947908
76telencephalon development (GO:0021537)2.71479793
77retina layer formation (GO:0010842)2.71418616
78formation of primary germ layer (GO:0001704)2.69804834
79negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.69483033
80DNA replication-independent nucleosome assembly (GO:0006336)2.68794794
81DNA replication-independent nucleosome organization (GO:0034724)2.68794794
82anterior/posterior axis specification, embryo (GO:0008595)2.63652134
83N-glycan processing (GO:0006491)2.63128979
84UDP-N-acetylglucosamine metabolic process (GO:0006047)2.62146348
85negative regulation of hormone biosynthetic process (GO:0032353)2.60888593
86positive regulation of cardiac muscle tissue growth (GO:0055023)2.59722804
87negative regulation of cell fate commitment (GO:0010454)2.59576921
88cardiac muscle adaptation (GO:0014887)2.58385904
89cardiac muscle hypertrophy in response to stress (GO:0014898)2.58385904
90muscle hypertrophy in response to stress (GO:0003299)2.58385904
91meiosis I (GO:0007127)2.58216690
92inner ear receptor cell development (GO:0060119)2.57474337
93regulation of axon extension involved in axon guidance (GO:0048841)2.57035178
94dorsal/ventral pattern formation (GO:0009953)2.56232670
95protein K6-linked ubiquitination (GO:0085020)2.54468903
96positive regulation of cardiac muscle cell differentiation (GO:2000727)2.54443011
97limb bud formation (GO:0060174)2.50203183
98regulation of acrosome reaction (GO:0060046)2.49064066
99negative regulation of retinoic acid receptor signaling pathway (GO:0048387)16.9667204
100regulation of retinoic acid receptor signaling pathway (GO:0048385)14.2264685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92486760
2SMAD3_21741376_ChIP-Seq_HESCs_Human3.44891634
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.43252227
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.15313046
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.15313046
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.15313046
7GBX2_23144817_ChIP-Seq_PC3_Human2.97328363
8EZH2_22144423_ChIP-Seq_EOC_Human2.79616417
9* SMAD4_21741376_ChIP-Seq_HESCs_Human2.76833214
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75159431
11SMAD3_21741376_ChIP-Seq_EPCs_Human2.47548058
12ZNF274_21170338_ChIP-Seq_K562_Hela2.38932199
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.36416115
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33648189
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32884329
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.30577075
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.23200333
18SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.17486012
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16841869
20* P300_19829295_ChIP-Seq_ESCs_Human2.07070076
21TOP2B_26459242_ChIP-Seq_MCF-7_Human2.05471774
22VDR_22108803_ChIP-Seq_LS180_Human2.05073125
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.96547271
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94537456
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.93034555
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.87299415
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85312358
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.85012457
29IGF1R_20145208_ChIP-Seq_DFB_Human1.84902434
30SMAD4_21741376_ChIP-Seq_EPCs_Human1.83410717
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75569978
32TAF15_26573619_Chip-Seq_HEK293_Human1.73368409
33MYC_18940864_ChIP-ChIP_HL60_Human1.71252967
34EOMES_21245162_ChIP-Seq_HESCs_Human1.69632624
35GABP_17652178_ChIP-ChIP_JURKAT_Human1.67602280
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.67154416
37EWS_26573619_Chip-Seq_HEK293_Human1.64901164
38RNF2_27304074_Chip-Seq_NSC_Mouse1.58725021
39BCAT_22108803_ChIP-Seq_LS180_Human1.58155840
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.53877076
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.53223864
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52311457
43AR_25329375_ChIP-Seq_VCAP_Human1.51770496
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.50470360
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49605892
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46710224
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45891673
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44938377
49PRDM14_20953172_ChIP-Seq_ESCs_Human1.44726850
50ELK1_19687146_ChIP-ChIP_HELA_Human1.41704364
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.37638849
52CBP_20019798_ChIP-Seq_JUKART_Human1.36026645
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36026645
54* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34828969
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.32946230
56TP53_22573176_ChIP-Seq_HFKS_Human1.31995601
57SMAD4_21799915_ChIP-Seq_A2780_Human1.30735176
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.30047887
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29844056
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28080702
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27758390
62RUNX2_22187159_ChIP-Seq_PCA_Human1.27545061
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24945250
64TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22226555
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21615464
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.21589785
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20043145
68SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18704757
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17189261
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.16454545
71TCF4_22108803_ChIP-Seq_LS180_Human1.15335001
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14700894
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14700894
74NANOG_19829295_ChIP-Seq_ESCs_Human1.14633901
75SOX2_19829295_ChIP-Seq_ESCs_Human1.14633901
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14178507
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13417248
78TCF4_23295773_ChIP-Seq_U87_Human1.13167804
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11142749
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10227551
81HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10144196
82JARID2_20064375_ChIP-Seq_MESCs_Mouse1.09479602
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08908248
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08541336
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08455270
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07788028
87IRF1_19129219_ChIP-ChIP_H3396_Human1.07025651
88LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02082088
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00165656
90MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98367428
91* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96949073
92STAT3_23295773_ChIP-Seq_U87_Human0.96888116
93SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96049989
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95754394
95* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95452896
96PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95403334
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94216290
98KDM2B_26808549_Chip-Seq_REH_Human0.93468519
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.93162383
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92863721

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003119_abnormal_digestive_system3.54015399
2MP0005423_abnormal_somatic_nervous3.42083260
3MP0003880_abnormal_central_pattern3.40889157
4MP0005394_taste/olfaction_phenotype2.95834034
5MP0005499_abnormal_olfactory_system2.95834034
6MP0008995_early_reproductive_senescence2.68912297
7MP0006292_abnormal_olfactory_placode2.59258267
8MP0008004_abnormal_stomach_pH2.44939323
9MP0002277_abnormal_respiratory_mucosa2.27252044
10MP0002102_abnormal_ear_morphology2.02529046
11MP0003890_abnormal_embryonic-extraembry10.7872181
12MP0001529_abnormal_vocalization1.97547718
13MP0010030_abnormal_orbit_morphology1.97153056
14MP0002736_abnormal_nociception_after1.87075292
15MP0006054_spinal_hemorrhage1.78821873
16MP0008877_abnormal_DNA_methylation1.65200799
17MP0004957_abnormal_blastocyst_morpholog1.60645182
18MP0004133_heterotaxia1.59656779
19MP0006072_abnormal_retinal_apoptosis1.56254937
20MP0001293_anophthalmia1.55466985
21MP0003121_genomic_imprinting1.53390676
22MP0000462_abnormal_digestive_system1.50451683
23MP0000049_abnormal_middle_ear1.44839390
24MP0002084_abnormal_developmental_patter1.40989485
25MP0001929_abnormal_gametogenesis1.37250869
26MP0001986_abnormal_taste_sensitivity1.35396715
27MP0004859_abnormal_synaptic_plasticity1.33839269
28MP0002127_abnormal_cardiovascular_syste1.32045001
29MP0001672_abnormal_embryogenesis/_devel1.31437872
30MP0005380_embryogenesis_phenotype1.31437872
31MP0006276_abnormal_autonomic_nervous1.29131984
32MP0000428_abnormal_craniofacial_morphol1.27807562
33MP0001968_abnormal_touch/_nociception1.27348134
34MP0002210_abnormal_sex_determination1.26147657
35MP0002822_catalepsy1.23777516
36MP0002233_abnormal_nose_morphology1.22101025
37MP0003718_maternal_effect1.20015613
38MP0003635_abnormal_synaptic_transmissio1.16043693
39MP0001984_abnormal_olfaction1.15018036
40MP0002272_abnormal_nervous_system1.13975978
41MP0005551_abnormal_eye_electrophysiolog1.11487193
42MP0001286_abnormal_eye_development1.10158036
43MP0002751_abnormal_autonomic_nervous1.07939345
44MP0003937_abnormal_limbs/digits/tail_de1.07270938
45MP0008058_abnormal_DNA_repair1.06256002
46MP0002254_reproductive_system_inflammat1.05722422
47MP0002557_abnormal_social/conspecific_i1.05175769
48MP0002184_abnormal_innervation1.02107148
49MP0002572_abnormal_emotion/affect_behav1.01701392
50MP0010094_abnormal_chromosome_stability1.00731756
51MP0003943_abnormal_hepatobiliary_system0.99881820
52MP0002111_abnormal_tail_morphology0.99275708
53MP0009046_muscle_twitch0.96567927
54MP0005410_abnormal_fertilization0.95111923
55MP0001485_abnormal_pinna_reflex0.94856799
56MP0003698_abnormal_male_reproductive0.94407668
57MP0003195_calcinosis0.94355483
58MP0000778_abnormal_nervous_system0.92317975
59MP0003385_abnormal_body_wall0.91108542
60MP0002085_abnormal_embryonic_tissue0.91042476
61MP0000653_abnormal_sex_gland0.90937198
62MP0004215_abnormal_myocardial_fiber0.90212272
63MP0001730_embryonic_growth_arrest0.89902165
64MP0000762_abnormal_tongue_morphology0.88884446
65MP0002234_abnormal_pharynx_morphology0.88796862
66MP0000569_abnormal_digit_pigmentation0.88709562
67MP0002735_abnormal_chemical_nociception0.88528139
68MP0003283_abnormal_digestive_organ0.86300972
69MP0008789_abnormal_olfactory_epithelium0.84144071
70MP0002734_abnormal_mechanical_nocicepti0.84118515
71MP0005253_abnormal_eye_physiology0.83484170
72MP0009745_abnormal_behavioral_response0.83285256
73MP0003935_abnormal_craniofacial_develop0.81986946
74MP0003936_abnormal_reproductive_system0.81845392
75MP0001727_abnormal_embryo_implantation0.81573168
76MP0000955_abnormal_spinal_cord0.81289412
77MP0003787_abnormal_imprinting0.79084040
78MP0003137_abnormal_impulse_conducting0.78160657
79MP0001145_abnormal_male_reproductive0.77128684
80MP0003693_abnormal_embryo_hatching0.77002947
81MP0003699_abnormal_female_reproductive0.76903646
82MP0008932_abnormal_embryonic_tissue0.76457939
83MP0002160_abnormal_reproductive_system0.76207457
84MP0002161_abnormal_fertility/fecundity0.75193711
85MP0003861_abnormal_nervous_system0.75076403
86MP0000372_irregular_coat_pigmentation0.74280831
87MP0003786_premature_aging0.74040350
88MP0005645_abnormal_hypothalamus_physiol0.72666263
89MP0005386_behavior/neurological_phenoty0.72497204
90MP0004924_abnormal_behavior0.72497204
91MP0002752_abnormal_somatic_nervous0.72415526
92MP0002067_abnormal_sensory_capabilities0.70761523
93MP0002088_abnormal_embryonic_growth/wei0.70716865
94MP0001879_abnormal_lymphatic_vessel0.68878654
95MP0004085_abnormal_heartbeat0.68523018
96MP0003984_embryonic_growth_retardation0.68298896
97MP0001502_abnormal_circadian_rhythm0.67187312
98MP0001697_abnormal_embryo_size0.62653287
99MP0002932_abnormal_joint_morphology0.61799641
100MP0002152_abnormal_brain_morphology0.61785792

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fetal cardiovascular system (HP:0010948)5.86847836
2Abnormal umbilical cord blood vessels (HP:0011403)5.86847836
3Single umbilical artery (HP:0001195)5.86847836
4Abnormal pancreas size (HP:0012094)5.29723574
5Abdominal situs inversus (HP:0003363)4.67387407
6Abnormality of abdominal situs (HP:0011620)4.67387407
7Double outlet right ventricle (HP:0001719)4.40352684
8Congenital malformation of the right heart (HP:0011723)4.40352684
9Gonadotropin excess (HP:0000837)4.28153192
10Preauricular pit (HP:0004467)3.83805879
11Periauricular skin pits (HP:0100277)3.83805879
12Septo-optic dysplasia (HP:0100842)3.68957142
13Anal stenosis (HP:0002025)3.54361533
14Abnormality of the umbilical cord (HP:0010881)3.51593704
15Hypoplastic pelvis (HP:0008839)3.40251135
16Aplasia/hypoplasia of the humerus (HP:0006507)3.34082708
17Short humerus (HP:0005792)3.31576858
18Volvulus (HP:0002580)3.15400696
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.12320527
20Limb dystonia (HP:0002451)3.01861280
21Rectal fistula (HP:0100590)2.93920912
22Rectovaginal fistula (HP:0000143)2.93920912
23Premature ovarian failure (HP:0008209)2.89157306
24Abnormality of the aortic arch (HP:0012303)2.86194072
25Patent foramen ovale (HP:0001655)2.85754712
26Rhinitis (HP:0012384)2.75602420
27Cortical dysplasia (HP:0002539)2.72767081
28Asplenia (HP:0001746)2.71046363
29Abnormality of the pubic bones (HP:0003172)2.64546618
30Abnormal respiratory motile cilium physiology (HP:0012261)2.63936225
31Oligodactyly (hands) (HP:0001180)2.58429828
32Hydroxyprolinuria (HP:0003080)2.58239636
33Abnormality of proline metabolism (HP:0010907)2.58239636
34Anophthalmia (HP:0000528)2.54091130
35Vaginal fistula (HP:0004320)2.51857120
36Short tibia (HP:0005736)2.51780270
37Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.50847047
38Transposition of the great arteries (HP:0001669)2.49388584
39Abnormal connection of the cardiac segments (HP:0011545)2.49388584
40Abnormal ventriculo-arterial connection (HP:0011563)2.49388584
41Absent/shortened dynein arms (HP:0200106)2.46724421
42Dynein arm defect of respiratory motile cilia (HP:0012255)2.46724421
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.45894615
44Aplasia/Hypoplasia of the spleen (HP:0010451)2.43910354
45Increased serum pyruvate (HP:0003542)2.41897993
46Gonadal dysgenesis (HP:0000133)2.40477885
47Intestinal fistula (HP:0100819)2.36897579
48Proximal placement of thumb (HP:0009623)2.30507299
49Skin pits (HP:0100276)2.30157009
50Anal atresia (HP:0002023)2.29719477
51Anteriorly placed anus (HP:0001545)2.28007277
52Progressive inability to walk (HP:0002505)2.22945122
53Optic nerve hypoplasia (HP:0000609)2.22015881
54Ureteral duplication (HP:0000073)2.20023665
55Abnormalities of placenta or umbilical cord (HP:0001194)2.19421622
56Abnormality of the septum pellucidum (HP:0007375)2.18186718
57Abnormality of glycolysis (HP:0004366)2.18129440
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.16946263
59Genital tract atresia (HP:0001827)2.16902658
60Abnormal lung lobation (HP:0002101)2.13539421
61Absent septum pellucidum (HP:0001331)2.12355346
62Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.11478967
63Bile duct proliferation (HP:0001408)2.11045643
64Abnormal biliary tract physiology (HP:0012439)2.11045643
65Abnormal ciliary motility (HP:0012262)2.06463945
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.05682967
67Deviation of the thumb (HP:0009603)2.04023735
68Chronic bronchitis (HP:0004469)2.03907708
69Myokymia (HP:0002411)2.03238532
70Aplasia/Hypoplasia of the uvula (HP:0010293)1.99167773
71Vaginal atresia (HP:0000148)1.98063295
72Midline defect of the nose (HP:0004122)1.97421402
73Short middle phalanx of the 5th finger (HP:0004220)1.96879537
74Abnormality of chromosome stability (HP:0003220)1.94895027
75Bifid tongue (HP:0010297)1.94256885
76Prominent supraorbital ridges (HP:0000336)1.89574471
77Abnormality of the phalanges of the 5th finger (HP:0004213)1.85604683
78Abnormal vertebral ossification (HP:0100569)1.85588795
79Atonic seizures (HP:0010819)1.84597163
80Short 1st metacarpal (HP:0010034)1.84298516
81Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.84298516
82Abnormality of methionine metabolism (HP:0010901)1.83393083
83Ectopic anus (HP:0004397)1.82942085
84Multiple enchondromatosis (HP:0005701)1.81994843
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.81160403
86Hypoplasia of the fovea (HP:0007750)1.80976234
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.80976234
88Atrophy/Degeneration involving motor neurons (HP:0007373)1.80713795
89Preaxial foot polydactyly (HP:0001841)1.78589648
90Abnormality of the corticospinal tract (HP:0002492)1.78108931
91Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75979303
92Abnormality of the anterior horn cell (HP:0006802)1.73864405
93Degeneration of anterior horn cells (HP:0002398)1.73864405
94Tetraparesis (HP:0002273)1.71620464
95Amelogenesis imperfecta (HP:0000705)1.71477077
96Action tremor (HP:0002345)1.71289675
97Abnormal respiratory motile cilium morphology (HP:0005938)1.70303903
98Abnormal respiratory epithelium morphology (HP:0012253)1.70303903
99Abnormal auditory evoked potentials (HP:0006958)1.70036972
100Stenosis of the external auditory canal (HP:0000402)1.68806155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B7.91961820
2BMPR1B5.08474906
3TRIM283.83631496
4TNIK3.61585330
5ERBB43.44223842
6PBK3.18822558
7SIK32.20112772
8TGFBR12.15352157
9MAP3K92.06845736
10CASK2.05148477
11SRPK12.00685309
12PLK41.99119098
13EPHA41.92097307
14NUAK11.84870356
15ERBB31.79890844
16STK161.76038196
17STK391.73497219
18MAPK131.70616697
19WNK31.66160229
20ZAK1.50776822
21BCR1.50438586
22STK101.49570112
23PRKD31.49248533
24PKN21.40308862
25RAF11.32119163
26WNK41.29521989
27LATS21.22086801
28MST41.17572564
29ADRBK11.16900214
30PLK21.14277847
31DMPK1.10518288
32TLK11.04260260
33ARAF0.97217376
34MELK0.93003047
35MAP3K40.91326320
36MAP4K20.90941380
37CDK190.90309701
38FLT30.89504977
39PLK30.89134454
40OXSR10.86950249
41MINK10.79565130
42AURKA0.78488296
43MARK10.71197623
44NTRK30.68170405
45PLK10.68086487
46VRK10.67739564
47EIF2AK30.66028141
48NTRK20.60547648
49DAPK20.60503327
50CSNK1G10.57858163
51LRRK20.53027689
52MKNK20.51945099
53PRKCQ0.51718998
54BRSK10.51251420
55CSNK1G20.49503643
56WEE10.49004562
57CAMK2A0.48912510
58KSR10.46877426
59EIF2AK20.44318268
60FER0.43458484
61TSSK60.42470788
62BRSK20.41298133
63DYRK30.40765622
64MAP2K10.39786697
65WNK10.39782245
66BCKDK0.37803656
67AURKB0.35350658
68ROCK10.34749511
69MAPKAPK30.33381474
70CDK180.33354179
71TTK0.33265293
72PDK20.32114320
73TEC0.31443530
74MAP2K70.30694680
75PAK10.29819290
76MAP3K80.28369407
77PAK30.27984290
78CSNK1E0.26391648
79INSRR0.26148585
80CDK140.25090565
81NEK60.24450110
82STK30.24405690
83ROCK20.24393378
84PAK60.23511703
85SGK20.23494020
86GRK10.23086066
87CHEK10.22853327
88STK38L0.22665956
89ATM0.22412780
90PRKCE0.22382173
91CDK11A0.21942402
92PRKG10.20359889
93ATR0.20339672
94PRKCG0.20293070
95CDK150.19977768
96TAF10.19907058
97CDK10.18396261
98CHEK20.17167833
99CDK50.16939600
100ILK0.16249834

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.54410671
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.39470190
3Protein export_Homo sapiens_hsa030602.87396391
4Steroid biosynthesis_Homo sapiens_hsa001002.79426277
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.67448075
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.57500062
7Nicotine addiction_Homo sapiens_hsa050332.49424104
8Wnt signaling pathway_Homo sapiens_hsa043102.31966228
9Pyruvate metabolism_Homo sapiens_hsa006202.17289829
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04772033
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87654219
12Propanoate metabolism_Homo sapiens_hsa006401.86660557
13Caffeine metabolism_Homo sapiens_hsa002321.82690760
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.80230350
15Olfactory transduction_Homo sapiens_hsa047401.69100055
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.66428287
17GABAergic synapse_Homo sapiens_hsa047271.63133333
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56661889
19RNA transport_Homo sapiens_hsa030131.52529206
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.44033526
21RNA degradation_Homo sapiens_hsa030181.43467011
22Morphine addiction_Homo sapiens_hsa050321.42217430
23Fanconi anemia pathway_Homo sapiens_hsa034601.40977411
24Fatty acid elongation_Homo sapiens_hsa000621.39138764
25Non-homologous end-joining_Homo sapiens_hsa034501.36906987
26TGF-beta signaling pathway_Homo sapiens_hsa043501.36574324
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.35781115
28Proteasome_Homo sapiens_hsa030501.35540674
29Regulation of autophagy_Homo sapiens_hsa041401.35519836
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34521376
31Phototransduction_Homo sapiens_hsa047441.32854139
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28912179
33Taste transduction_Homo sapiens_hsa047421.27820105
34Hedgehog signaling pathway_Homo sapiens_hsa043401.27334098
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.26779829
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25898487
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21081142
38Oocyte meiosis_Homo sapiens_hsa041141.20954776
39Mismatch repair_Homo sapiens_hsa034301.20289450
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19412082
41Folate biosynthesis_Homo sapiens_hsa007901.17968884
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17034799
43Fatty acid metabolism_Homo sapiens_hsa012121.16483545
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15745409
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.15278427
46mRNA surveillance pathway_Homo sapiens_hsa030151.14436986
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12914593
48RNA polymerase_Homo sapiens_hsa030201.12557268
49Cell cycle_Homo sapiens_hsa041101.11062682
50Butanoate metabolism_Homo sapiens_hsa006501.10401913
51Hippo signaling pathway_Homo sapiens_hsa043901.09212740
52Basal cell carcinoma_Homo sapiens_hsa052171.09045120
53Serotonergic synapse_Homo sapiens_hsa047261.01540096
54Synaptic vesicle cycle_Homo sapiens_hsa047211.01161630
55Collecting duct acid secretion_Homo sapiens_hsa049660.87457083
56Peroxisome_Homo sapiens_hsa041460.86789229
57Homologous recombination_Homo sapiens_hsa034400.85937972
58Dopaminergic synapse_Homo sapiens_hsa047280.83147477
59Circadian entrainment_Homo sapiens_hsa047130.81673514
60Huntingtons disease_Homo sapiens_hsa050160.77415036
61Parkinsons disease_Homo sapiens_hsa050120.76328181
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71325594
63Cholinergic synapse_Homo sapiens_hsa047250.68418403
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67822190
65cAMP signaling pathway_Homo sapiens_hsa040240.63801624
66p53 signaling pathway_Homo sapiens_hsa041150.63307598
67Calcium signaling pathway_Homo sapiens_hsa040200.60950979
68Glutamatergic synapse_Homo sapiens_hsa047240.59102942
69Insulin secretion_Homo sapiens_hsa049110.58748862
70Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58722444
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57320027
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55625521
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55387682
74Circadian rhythm_Homo sapiens_hsa047100.54892984
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53113028
76Oxidative phosphorylation_Homo sapiens_hsa001900.52677513
77Spliceosome_Homo sapiens_hsa030400.51459252
78Dorso-ventral axis formation_Homo sapiens_hsa043200.50982498
79Arginine and proline metabolism_Homo sapiens_hsa003300.49911016
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49121748
81Tryptophan metabolism_Homo sapiens_hsa003800.48110064
82Retinol metabolism_Homo sapiens_hsa008300.47257759
83Amphetamine addiction_Homo sapiens_hsa050310.43560299
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.43350855
85Base excision repair_Homo sapiens_hsa034100.42621485
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42408073
87Fatty acid degradation_Homo sapiens_hsa000710.42119428
88Colorectal cancer_Homo sapiens_hsa052100.39075007
89beta-Alanine metabolism_Homo sapiens_hsa004100.38946139
90Melanogenesis_Homo sapiens_hsa049160.38670425
91Metabolic pathways_Homo sapiens_hsa011000.36993115
92Gastric acid secretion_Homo sapiens_hsa049710.36600625
93Oxytocin signaling pathway_Homo sapiens_hsa049210.34665611
94Vitamin B6 metabolism_Homo sapiens_hsa007500.32980661
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32008265
96Ovarian steroidogenesis_Homo sapiens_hsa049130.30586382
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.29466472
98Purine metabolism_Homo sapiens_hsa002300.25534340
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24503334
100Cocaine addiction_Homo sapiens_hsa050300.24426047

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