RFPL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)7.62568222
2male meiosis (GO:0007140)6.88267612
3regulation of mesoderm development (GO:2000380)6.58514367
4chromosome organization involved in meiosis (GO:0070192)6.31845024
5positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.17069829
6phospholipid scrambling (GO:0017121)6.11022154
7histone exchange (GO:0043486)5.90936749
8positive regulation of catecholamine secretion (GO:0033605)5.71768382
9binding of sperm to zona pellucida (GO:0007339)5.69762964
10DNA replication-dependent nucleosome assembly (GO:0006335)5.61056710
11DNA replication-dependent nucleosome organization (GO:0034723)5.61056710
12synaptonemal complex assembly (GO:0007130)5.45132133
13regulation of phosphoprotein phosphatase activity (GO:0043666)5.39627083
14synaptonemal complex organization (GO:0070193)5.23656175
15cell migration involved in gastrulation (GO:0042074)5.22506819
16endoderm formation (GO:0001706)5.10428469
17negative regulation of activin receptor signaling pathway (GO:0032926)5.04894342
18sequestering of extracellular ligand from receptor (GO:0035581)4.88649096
19multicellular organism reproduction (GO:0032504)4.83683716
20chromatin remodeling at centromere (GO:0031055)4.80834985
21CENP-A containing nucleosome assembly (GO:0034080)4.76982121
22DNA double-strand break processing (GO:0000729)4.57172625
23spermatid development (GO:0007286)4.55978527
24regulation of penile erection (GO:0060405)4.55574765
25sperm-egg recognition (GO:0035036)4.52374538
26regulation of oxidative phosphorylation (GO:0002082)4.45967030
27positive regulation of uterine smooth muscle contraction (GO:0070474)4.33155348
28signal transduction involved in regulation of gene expression (GO:0023019)4.29211567
29DNA synthesis involved in DNA repair (GO:0000731)4.28916990
30DNA replication checkpoint (GO:0000076)4.23563516
31acrosome reaction (GO:0007340)4.20990584
32histone H3-K9 demethylation (GO:0033169)4.04176964
33meiotic nuclear division (GO:0007126)4.00227957
34axonemal dynein complex assembly (GO:0070286)3.92817450
35cell-cell recognition (GO:0009988)3.92616135
36male meiosis I (GO:0007141)3.87269517
37piRNA metabolic process (GO:0034587)3.73025717
38positive regulation of amine transport (GO:0051954)3.58678180
39resolution of meiotic recombination intermediates (GO:0000712)3.51619700
40epithelial cilium movement (GO:0003351)3.50318583
41meiotic cell cycle process (GO:1903046)3.49562983
42negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.48199681
43somite rostral/caudal axis specification (GO:0032525)3.46737258
44regulation of activin receptor signaling pathway (GO:0032925)3.42864085
45cellular response to BMP stimulus (GO:0071773)3.40294305
46response to BMP (GO:0071772)3.40294305
47anterior/posterior axis specification (GO:0009948)3.39900875
48negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.38207232
49DNA replication-independent nucleosome organization (GO:0034724)3.35857342
50DNA replication-independent nucleosome assembly (GO:0006336)3.35857342
51reproduction (GO:0000003)3.34170256
52sperm motility (GO:0030317)3.31295325
53single fertilization (GO:0007338)3.28848201
54regulation of uterine smooth muscle contraction (GO:0070472)3.27630174
55cilium movement (GO:0003341)3.25383955
56polyamine biosynthetic process (GO:0006596)3.24273807
57gastrulation (GO:0007369)3.23925160
58positive regulation of protein homodimerization activity (GO:0090073)3.15805708
59primitive streak formation (GO:0090009)3.13418995
60purine nucleobase biosynthetic process (GO:0009113)3.12557717
61meiosis I (GO:0007127)3.12299803
62regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.12155913
63regulation of cellular respiration (GO:0043457)3.11478150
64DNA deamination (GO:0045006)3.03729060
65regulation of oxidative stress-induced neuron death (GO:1903203)3.01165377
66telencephalon development (GO:0021537)3.00931444
67ATP-dependent chromatin remodeling (GO:0043044)2.98769172
68germ cell development (GO:0007281)2.96902053
69extracellular negative regulation of signal transduction (GO:1900116)2.96717863
70extracellular regulation of signal transduction (GO:1900115)2.96717863
71meiotic chromosome segregation (GO:0045132)2.96609285
72protein neddylation (GO:0045116)2.94575969
73DNA methylation involved in gamete generation (GO:0043046)2.89535304
74acrosome assembly (GO:0001675)2.87856707
75DNA ligation (GO:0006266)2.86804011
76response to histamine (GO:0034776)2.82776337
77non-recombinational repair (GO:0000726)2.79302342
78double-strand break repair via nonhomologous end joining (GO:0006303)2.79302342
79nucleobase biosynthetic process (GO:0046112)2.78966043
80pre-miRNA processing (GO:0031054)2.74626646
81regulation of synaptic transmission, dopaminergic (GO:0032225)2.74546457
82regulation of helicase activity (GO:0051095)2.73198215
83pyrimidine dimer repair (GO:0006290)2.71281838
84striatum development (GO:0021756)2.70526079
85DNA catabolic process, exonucleolytic (GO:0000738)2.68837147
86purine-containing compound salvage (GO:0043101)2.63778985
87genitalia morphogenesis (GO:0035112)2.62757982
88potassium ion export (GO:0071435)2.62600427
89N-terminal protein amino acid acetylation (GO:0006474)2.60829748
90negative regulation of striated muscle cell apoptotic process (GO:0010664)2.60624403
91aspartate family amino acid catabolic process (GO:0009068)2.60490237
92fertilization (GO:0009566)2.60302016
93proteasome assembly (GO:0043248)2.57173325
94sister chromatid cohesion (GO:0007062)2.56257010
95activation of protein kinase B activity (GO:0032148)2.50396578
96replication fork processing (GO:0031297)2.50038110
97positive regulation of meiotic cell cycle (GO:0051446)2.49778277
98chromosome organization (GO:0051276)2.49668056
99reciprocal meiotic recombination (GO:0007131)2.49529537
100reciprocal DNA recombination (GO:0035825)2.49529537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.34985689
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.39080092
3IGF1R_20145208_ChIP-Seq_DFB_Human4.22368250
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.11084261
5E2F7_22180533_ChIP-Seq_HELA_Human3.96411442
6VDR_22108803_ChIP-Seq_LS180_Human3.70805045
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.87819994
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86502744
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80962960
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79950101
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.72992106
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.33795549
13SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.22935129
14GBX2_23144817_ChIP-Seq_PC3_Human2.21751808
15P300_19829295_ChIP-Seq_ESCs_Human2.19975533
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.15430886
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.11768767
18FUS_26573619_Chip-Seq_HEK293_Human2.11612312
19BCAT_22108803_ChIP-Seq_LS180_Human2.03415207
20EWS_26573619_Chip-Seq_HEK293_Human2.02004408
21SMAD3_21741376_ChIP-Seq_EPCs_Human1.98782871
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95185529
23SMAD4_21741376_ChIP-Seq_HESCs_Human1.91719300
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.91092573
25CBP_20019798_ChIP-Seq_JUKART_Human1.91092573
26SMAD3_21741376_ChIP-Seq_HESCs_Human1.89112231
27SMAD4_21741376_ChIP-Seq_EPCs_Human1.83290722
28MYC_18940864_ChIP-ChIP_HL60_Human1.76193920
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.73545319
30TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70937852
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68473957
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64536044
33ZNF274_21170338_ChIP-Seq_K562_Hela1.64456152
34KLF5_20875108_ChIP-Seq_MESCs_Mouse1.64309959
35EZH2_22144423_ChIP-Seq_EOC_Human1.63282296
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.58061980
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53862849
38AR_21909140_ChIP-Seq_LNCAP_Human1.50851326
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.47653806
40PRDM14_20953172_ChIP-Seq_ESCs_Human1.46712901
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.46037984
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44211260
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41216289
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41186005
45IRF1_19129219_ChIP-ChIP_H3396_Human1.38038812
46AR_25329375_ChIP-Seq_VCAP_Human1.37211290
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36807053
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35005467
49SMAD4_21799915_ChIP-Seq_A2780_Human1.30859101
50ELK1_19687146_ChIP-ChIP_HELA_Human1.30535952
51SOX2_19829295_ChIP-Seq_ESCs_Human1.29688598
52NANOG_19829295_ChIP-Seq_ESCs_Human1.29688598
53ER_23166858_ChIP-Seq_MCF-7_Human1.29047523
54TCF4_22108803_ChIP-Seq_LS180_Human1.28052163
55RUNX2_22187159_ChIP-Seq_PCA_Human1.27750008
56JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.27466651
57TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25621245
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25621245
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21265923
60GATA1_26923725_Chip-Seq_HPCs_Mouse1.19978890
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.18195051
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15183746
63FOXH1_21741376_ChIP-Seq_EPCs_Human1.12590714
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.09607188
65NANOG_20526341_ChIP-Seq_ESCs_Human1.08271612
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06266491
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06266491
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06266491
69CDX2_22108803_ChIP-Seq_LS180_Human1.06247559
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05035706
71TAF15_26573619_Chip-Seq_HEK293_Human1.04485876
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03561264
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03527370
74GATA3_26560356_Chip-Seq_TH1_Human1.02583194
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02515821
76NCOR_22424771_ChIP-Seq_293T_Human1.01311360
77SMAD3_21741376_ChIP-Seq_ESCs_Human1.00972499
78* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99922748
79EOMES_21245162_ChIP-Seq_HESCs_Human0.98619259
80STAT3_23295773_ChIP-Seq_U87_Human0.98232995
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97707142
82NOTCH1_21737748_ChIP-Seq_TLL_Human0.97288413
83CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96896403
84JUN_21703547_ChIP-Seq_K562_Human0.96109848
85FOXP3_21729870_ChIP-Seq_TREG_Human0.95697768
86VDR_23849224_ChIP-Seq_CD4+_Human0.93577195
87* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93539086
88DCP1A_22483619_ChIP-Seq_HELA_Human0.93423341
89SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93390653
90WT1_19549856_ChIP-ChIP_CCG9911_Human0.93074550
91OCT4_20526341_ChIP-Seq_ESCs_Human0.92858550
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.92516276
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91588278
94VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91153826
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89765929
96P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89463746
97TP53_22573176_ChIP-Seq_HFKS_Human0.86203875
98RNF2_27304074_Chip-Seq_NSC_Mouse0.85979941
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85968008
100MYC_19829295_ChIP-Seq_ESCs_Human0.85642617

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry7.95300840
2MP0008004_abnormal_stomach_pH5.01263089
3MP0005410_abnormal_fertilization4.69363286
4MP0005394_taste/olfaction_phenotype3.39418297
5MP0005499_abnormal_olfactory_system3.39418297
6MP0003315_abnormal_perineum_morphology2.83552828
7MP0008058_abnormal_DNA_repair2.77685909
8MP0001929_abnormal_gametogenesis2.51882941
9MP0002277_abnormal_respiratory_mucosa2.50012984
10MP0008877_abnormal_DNA_methylation2.45282203
11MP0006292_abnormal_olfactory_placode2.38785779
12MP0002160_abnormal_reproductive_system2.38371578
13MP0003119_abnormal_digestive_system2.38266599
14MP0008789_abnormal_olfactory_epithelium2.31041082
15MP0003698_abnormal_male_reproductive2.20796695
16MP0009697_abnormal_copulation2.13615244
17MP0008995_early_reproductive_senescence2.10927598
18MP0002102_abnormal_ear_morphology2.09970880
19MP0002210_abnormal_sex_determination2.00330203
20MP0001529_abnormal_vocalization1.89284071
21MP0001984_abnormal_olfaction1.87485619
22MP0000049_abnormal_middle_ear1.83207379
23MP0006072_abnormal_retinal_apoptosis1.79712521
24MP0001293_anophthalmia1.64664807
25MP0010094_abnormal_chromosome_stability1.63508598
26MP0002233_abnormal_nose_morphology1.63205142
27MP0003880_abnormal_central_pattern1.62787016
28MP0002638_abnormal_pupillary_reflex1.53648678
29MP0001188_hyperpigmentation1.53321805
30MP0001145_abnormal_male_reproductive1.52134137
31MP0000653_abnormal_sex_gland1.50145415
32MP0002132_abnormal_respiratory_system1.49247145
33MP0003693_abnormal_embryo_hatching1.46906642
34MP0002736_abnormal_nociception_after1.42924460
35MP0003938_abnormal_ear_development1.31267380
36MP0002161_abnormal_fertility/fecundity1.26658561
37MP0005423_abnormal_somatic_nervous1.23511505
38MP0001286_abnormal_eye_development1.20341147
39MP0005647_abnormal_sex_gland1.17962651
40MP0004957_abnormal_blastocyst_morpholog1.17543245
41MP0005253_abnormal_eye_physiology1.17410152
42MP0005389_reproductive_system_phenotype1.11063730
43MP0002751_abnormal_autonomic_nervous1.09129401
44MP0003937_abnormal_limbs/digits/tail_de1.08639292
45MP0003936_abnormal_reproductive_system1.08142921
46MP0003136_yellow_coat_color1.06422965
47MP0003941_abnormal_skin_development1.06229628
48MP0002084_abnormal_developmental_patter1.03741999
49MP0001485_abnormal_pinna_reflex1.03676077
50MP0006036_abnormal_mitochondrial_physio1.03499168
51MP0005360_urolithiasis1.03052133
52MP0001664_abnormal_digestion1.01345454
53MP0002272_abnormal_nervous_system0.99483750
54MP0000026_abnormal_inner_ear0.98453294
55MP0005551_abnormal_eye_electrophysiolog0.97928444
56MP0001119_abnormal_female_reproductive0.97852392
57MP0002111_abnormal_tail_morphology0.97394336
58MP0002254_reproductive_system_inflammat0.97289919
59MP0005380_embryogenesis_phenotype0.95869076
60MP0001672_abnormal_embryogenesis/_devel0.95869076
61MP0000462_abnormal_digestive_system0.94211079
62MP0008932_abnormal_embryonic_tissue0.93900339
63MP0003077_abnormal_cell_cycle0.92568492
64MP0003806_abnormal_nucleotide_metabolis0.87369594
65MP0002938_white_spotting0.86937521
66MP0003111_abnormal_nucleus_morphology0.86173308
67MP0001963_abnormal_hearing_physiology0.85830424
68MP0002249_abnormal_larynx_morphology0.85725346
69MP0003786_premature_aging0.82693105
70MP0003755_abnormal_palate_morphology0.81159347
71MP0003718_maternal_effect0.80097713
72MP0008872_abnormal_physiological_respon0.79985423
73MP0006276_abnormal_autonomic_nervous0.79611283
74MP0004085_abnormal_heartbeat0.79431397
75MP0003935_abnormal_craniofacial_develop0.78284390
76MP0000428_abnormal_craniofacial_morphol0.77898847
77MP0000678_abnormal_parathyroid_gland0.77379599
78MP0005391_vision/eye_phenotype0.77315759
79MP0002085_abnormal_embryonic_tissue0.76266605
80MP0003699_abnormal_female_reproductive0.73838795
81MP0002127_abnormal_cardiovascular_syste0.72776889
82MP0001905_abnormal_dopamine_level0.72007242
83MP0000762_abnormal_tongue_morphology0.71988321
84MP0010030_abnormal_orbit_morphology0.70300973
85MP0009250_abnormal_appendicular_skeleto0.69995738
86MP0001502_abnormal_circadian_rhythm0.69852827
87MP0000372_irregular_coat_pigmentation0.69809955
88MP0004133_heterotaxia0.68646170
89MP0000631_abnormal_neuroendocrine_gland0.68625593
90MP0002752_abnormal_somatic_nervous0.67241736
91MP0006054_spinal_hemorrhage0.66426412
92MP0002184_abnormal_innervation0.65555696
93MP0003567_abnormal_fetal_cardiomyocyte0.65093762
94MP0004215_abnormal_myocardial_fiber0.62890706
95MP0006035_abnormal_mitochondrial_morpho0.62615210
96MP0008875_abnormal_xenobiotic_pharmacok0.60963700
97MP0000538_abnormal_urinary_bladder0.59018307
98MP0001968_abnormal_touch/_nociception0.57764876
99MP0002557_abnormal_social/conspecific_i0.56741153
100MP0005646_abnormal_pituitary_gland0.53186247

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.95770929
2Abnormal respiratory motile cilium physiology (HP:0012261)4.33052123
3Abnormal ciliary motility (HP:0012262)3.74095103
4Gonadal dysgenesis (HP:0000133)3.55269273
5Absent/shortened dynein arms (HP:0200106)3.53291012
6Dynein arm defect of respiratory motile cilia (HP:0012255)3.53291012
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.41388292
8Sensory axonal neuropathy (HP:0003390)3.31984824
9Sex reversal (HP:0012245)3.31780484
10Abnormal sex determination (HP:0012244)3.31780484
11Abnormality of chromosome stability (HP:0003220)3.31537167
12Gonadotropin excess (HP:0000837)3.30090127
13Abnormal respiratory motile cilium morphology (HP:0005938)3.23980682
14Abnormal respiratory epithelium morphology (HP:0012253)3.23980682
15Rhinitis (HP:0012384)3.05463831
16Premature ovarian failure (HP:0008209)3.02286441
17Short middle phalanx of the 5th finger (HP:0004220)2.98055602
18Hypoplasia of the uterus (HP:0000013)2.93450575
19Double outlet right ventricle (HP:0001719)2.83424215
20Congenital malformation of the right heart (HP:0011723)2.83424215
21Resting tremor (HP:0002322)2.81627423
22Abnormal pancreas size (HP:0012094)2.66563562
23Meckel diverticulum (HP:0002245)2.62863887
24Septo-optic dysplasia (HP:0100842)2.61865194
25Protruding tongue (HP:0010808)2.61526144
26Cortical dysplasia (HP:0002539)2.61455412
27Abnormal biliary tract physiology (HP:0012439)2.60744957
28Bile duct proliferation (HP:0001408)2.60744957
29Abnormality of the ileum (HP:0001549)2.59996221
30Abnormality of the fetal cardiovascular system (HP:0010948)2.56795991
31Abnormal umbilical cord blood vessels (HP:0011403)2.56795991
32Single umbilical artery (HP:0001195)2.56795991
33Acute necrotizing encephalopathy (HP:0006965)2.50769920
34Optic nerve hypoplasia (HP:0000609)2.44358122
35Abnormality of abdominal situs (HP:0011620)2.42246649
36Abdominal situs inversus (HP:0003363)2.42246649
37Chronic bronchitis (HP:0004469)2.41421630
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39689171
39Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.38901534
40Aplasia/hypoplasia of the uterus (HP:0008684)2.38599168
41Hypoplastic pelvis (HP:0008839)2.37297038
42Preauricular pit (HP:0004467)2.35629424
43Periauricular skin pits (HP:0100277)2.35629424
44Hyperglycinuria (HP:0003108)2.34269913
45Squamous cell carcinoma (HP:0002860)2.31132243
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.29679059
47Progressive macrocephaly (HP:0004481)2.27318307
48Male pseudohermaphroditism (HP:0000037)2.23784171
49Colon cancer (HP:0003003)2.22373316
50Acute encephalopathy (HP:0006846)2.21433448
51Median cleft lip (HP:0000161)2.21021339
52Upper limb muscle weakness (HP:0003484)2.20161071
53Oligodactyly (hands) (HP:0001180)2.17556653
54Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.12108918
55Chromsome breakage (HP:0040012)2.10175911
56Abnormality of cochlea (HP:0000375)2.09037937
57Abnormality of the preputium (HP:0100587)2.08658361
58Absent speech (HP:0001344)2.07987820
59Hyperglycinemia (HP:0002154)2.07746627
60Abnormal mitochondria in muscle tissue (HP:0008316)2.07325096
61Limb dystonia (HP:0002451)2.07133761
62Congenital sensorineural hearing impairment (HP:0008527)2.06668819
63Abnormality of glycine metabolism (HP:0010895)2.06595547
64Abnormality of serine family amino acid metabolism (HP:0010894)2.06595547
65Short humerus (HP:0005792)2.06090080
66Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.03331608
67Abnormality of the duodenum (HP:0002246)2.02535869
68Cerebral hypomyelination (HP:0006808)2.02287118
69Patent foramen ovale (HP:0001655)2.01031067
70Small intestinal stenosis (HP:0012848)1.97088388
71Duodenal stenosis (HP:0100867)1.97088388
72Absent thumb (HP:0009777)1.96858756
73Clubbing of toes (HP:0100760)1.96676711
74Dyschromatopsia (HP:0007641)1.95702180
75Aplasia/hypoplasia of the humerus (HP:0006507)1.94216177
76Abnormality of the phalanges of the 5th finger (HP:0004213)1.94110647
77Rectovaginal fistula (HP:0000143)1.93539125
78Rectal fistula (HP:0100590)1.93539125
79Anophthalmia (HP:0000528)1.91669454
80Atonic seizures (HP:0010819)1.90995837
81Abnormal auditory evoked potentials (HP:0006958)1.90598109
82Urinary urgency (HP:0000012)1.87907456
83Genital tract atresia (HP:0001827)1.86658515
84Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.83065067
85Anal stenosis (HP:0002025)1.82492733
86Abnormality of DNA repair (HP:0003254)1.81547266
87Volvulus (HP:0002580)1.79565320
88Anal atresia (HP:0002023)1.78676276
89Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78572582
90Poikiloderma (HP:0001029)1.78088880
91Hypoplasia of the pons (HP:0012110)1.77528834
92Abnormality of the pons (HP:0007361)1.76352730
93Nephrogenic diabetes insipidus (HP:0009806)1.76301468
94Primary amenorrhea (HP:0000786)1.74741351
95Vaginal atresia (HP:0000148)1.74612612
96Infertility (HP:0000789)1.74295943
97Pancreatic fibrosis (HP:0100732)1.73324955
98Cerebellar dysplasia (HP:0007033)1.71473020
99Small hand (HP:0200055)1.71079780
100Cerebral edema (HP:0002181)1.70900070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.00338510
2ZAK4.65717009
3ACVR1B4.43518370
4BMPR1B4.39793823
5MARK33.26296277
6TLK13.18948607
7PLK42.82705800
8CASK2.49949154
9PBK2.31420803
10TNIK2.24620695
11STK38L2.11863458
12VRK12.01829698
13TGFBR11.97188982
14SRPK11.93535126
15NUAK11.91074348
16WNK31.69048551
17RPS6KA51.65153603
18MYLK1.63006560
19ERBB41.61410551
20TAF11.57148273
21TRIM281.56792227
22STK161.47337443
23CDK31.38892131
24FRK1.29857270
25BCR1.23279728
26TTK1.21943898
27CDC71.20728539
28NEK21.19203821
29PLK11.12845585
30MAP2K71.08253251
31PLK31.07764261
32CSNK1G11.05988054
33PLK21.01537450
34ERBB30.97890283
35BRSK20.97607277
36MKNK20.90947900
37PRKCQ0.88778147
38TEC0.88218786
39MELK0.88121566
40MAPK130.84187968
41CSNK1G30.81939644
42LATS10.80174968
43CSNK1G20.75844772
44DYRK20.75695021
45PTK2B0.75684004
46AURKA0.73533335
47ADRBK20.73226078
48GRK10.72804673
49PAK10.71932377
50CSNK1A1L0.68618284
51STK380.67940172
52ADRBK10.66851249
53DYRK30.66274414
54STK30.65557498
55OXSR10.64904397
56ATR0.63293091
57VRK20.59455688
58EIF2AK30.58523426
59WEE10.57539094
60SGK4940.57391274
61SGK2230.57391274
62BRSK10.57358215
63AURKB0.57123810
64CLK10.57059685
65CDK140.57042155
66TIE10.56705727
67STK100.56105838
68STK240.55315061
69STK390.51627053
70WNK40.51615976
71TAOK30.50709899
72ATM0.50398075
73CDK190.49896021
74ROCK10.46588104
75RAF10.45437999
76MAP3K50.44059763
77OBSCN0.41853721
78DAPK30.41438412
79CHEK20.35580369
80STK40.35319106
81LATS20.34604490
82NEK90.34143470
83FLT30.33346423
84MAP4K20.32426799
85PKN10.30031189
86CSNK2A10.28337884
87DMPK0.26646947
88CSNK2A20.26298060
89NME20.26020971
90CHEK10.25625356
91SGK20.24752907
92FGR0.24593968
93MAPKAPK30.22678655
94BRAF0.22307662
95MKNK10.21993376
96EIF2AK20.21977713
97DYRK1A0.21521283
98FGFR10.21474914
99PRKG10.20536967
100TSSK60.20300245

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.83452719
2Propanoate metabolism_Homo sapiens_hsa006403.02872893
3Proteasome_Homo sapiens_hsa030502.88416540
4Cysteine and methionine metabolism_Homo sapiens_hsa002702.47924976
5Hedgehog signaling pathway_Homo sapiens_hsa043402.35712841
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34933990
7One carbon pool by folate_Homo sapiens_hsa006702.29504549
8Protein export_Homo sapiens_hsa030602.27072690
9Pyruvate metabolism_Homo sapiens_hsa006202.26041599
10Mismatch repair_Homo sapiens_hsa034302.14635558
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00660121
12Fanconi anemia pathway_Homo sapiens_hsa034601.98351978
13Basal transcription factors_Homo sapiens_hsa030221.94643290
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.92607602
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91692650
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81377986
17Gap junction_Homo sapiens_hsa045401.78608225
18DNA replication_Homo sapiens_hsa030301.73681248
19Steroid biosynthesis_Homo sapiens_hsa001001.65743515
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65683546
21Butanoate metabolism_Homo sapiens_hsa006501.64137740
22Homologous recombination_Homo sapiens_hsa034401.57760453
23RNA degradation_Homo sapiens_hsa030181.56207298
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56151850
25RNA transport_Homo sapiens_hsa030131.54168390
26Olfactory transduction_Homo sapiens_hsa047401.53143390
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51745588
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50042807
29Non-homologous end-joining_Homo sapiens_hsa034501.39695155
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.38821771
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37501566
32Nicotine addiction_Homo sapiens_hsa050331.32573369
33Wnt signaling pathway_Homo sapiens_hsa043101.32490500
34Apoptosis_Homo sapiens_hsa042101.24604551
35Glutathione metabolism_Homo sapiens_hsa004801.23291250
36Systemic lupus erythematosus_Homo sapiens_hsa053221.23170541
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.22629770
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22222502
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21057188
40Cell cycle_Homo sapiens_hsa041101.11695160
41Fatty acid elongation_Homo sapiens_hsa000621.07747875
42Oocyte meiosis_Homo sapiens_hsa041141.06932402
43p53 signaling pathway_Homo sapiens_hsa041151.03230708
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01412404
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.01199804
46Parkinsons disease_Homo sapiens_hsa050120.99982541
47Arginine biosynthesis_Homo sapiens_hsa002200.98546682
48Selenocompound metabolism_Homo sapiens_hsa004500.96743636
49Circadian rhythm_Homo sapiens_hsa047100.95928467
50Primary bile acid biosynthesis_Homo sapiens_hsa001200.93680029
51Base excision repair_Homo sapiens_hsa034100.93532262
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92892819
53Fatty acid metabolism_Homo sapiens_hsa012120.91555507
54Retinol metabolism_Homo sapiens_hsa008300.90389305
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88869802
56Regulation of autophagy_Homo sapiens_hsa041400.87492786
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86335962
58Peroxisome_Homo sapiens_hsa041460.86229057
59Tryptophan metabolism_Homo sapiens_hsa003800.85959960
60Caffeine metabolism_Homo sapiens_hsa002320.85954956
61Spliceosome_Homo sapiens_hsa030400.83886996
62Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83343079
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83341517
64beta-Alanine metabolism_Homo sapiens_hsa004100.81917896
65Alcoholism_Homo sapiens_hsa050340.79776114
66Purine metabolism_Homo sapiens_hsa002300.78267655
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.78118298
68mRNA surveillance pathway_Homo sapiens_hsa030150.77712022
69Huntingtons disease_Homo sapiens_hsa050160.75515048
70Nucleotide excision repair_Homo sapiens_hsa034200.75462577
71Phagosome_Homo sapiens_hsa041450.72787391
72Pyrimidine metabolism_Homo sapiens_hsa002400.69170421
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68592026
74Nitrogen metabolism_Homo sapiens_hsa009100.68380588
75Biosynthesis of amino acids_Homo sapiens_hsa012300.64143295
76Oxidative phosphorylation_Homo sapiens_hsa001900.61708627
77Basal cell carcinoma_Homo sapiens_hsa052170.61365142
78Carbon metabolism_Homo sapiens_hsa012000.61353196
79Metabolic pathways_Homo sapiens_hsa011000.59770107
80Taste transduction_Homo sapiens_hsa047420.57671074
81RNA polymerase_Homo sapiens_hsa030200.57597173
82TGF-beta signaling pathway_Homo sapiens_hsa043500.56246285
83Chemical carcinogenesis_Homo sapiens_hsa052040.53590756
84Ribosome_Homo sapiens_hsa030100.52030428
85Arginine and proline metabolism_Homo sapiens_hsa003300.51403520
86Fatty acid degradation_Homo sapiens_hsa000710.50251146
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50096103
88GABAergic synapse_Homo sapiens_hsa047270.47857517
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.44453349
90Tyrosine metabolism_Homo sapiens_hsa003500.41998727
91Phototransduction_Homo sapiens_hsa047440.41048684
92Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40959658
93Vitamin digestion and absorption_Homo sapiens_hsa049770.36945168
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36632327
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.33195426
96Protein digestion and absorption_Homo sapiens_hsa049740.31533129
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29984840
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.29631430
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29261256
100Dorso-ventral axis formation_Homo sapiens_hsa043200.28289894

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »