RFPL4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of acrosome reaction (GO:0060046)5.19865064
2regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.72122565
3regulation of female gonad development (GO:2000194)4.66616355
4mitotic chromosome condensation (GO:0007076)4.61021162
5positive regulation of mast cell activation involved in immune response (GO:0033008)4.30584401
6positive regulation of mast cell degranulation (GO:0043306)4.30584401
7regulation of DNA methylation (GO:0044030)4.14699883
8adenosine receptor signaling pathway (GO:0001973)4.14269063
9male meiosis I (GO:0007141)4.00719779
10negative regulation of retinoic acid receptor signaling pathway (GO:0048387)33.8349294
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.95967870
12positive regulation of prostaglandin secretion (GO:0032308)3.87890561
13positive regulation of uterine smooth muscle contraction (GO:0070474)3.86319586
14apoptotic DNA fragmentation (GO:0006309)3.80315533
15histamine secretion (GO:0001821)3.79081809
16regulation of cytokine production involved in inflammatory response (GO:1900015)3.76059430
17hyperosmotic salinity response (GO:0042538)3.63125848
18multicellular organism reproduction (GO:0032504)3.62483494
19meiosis I (GO:0007127)3.59455047
20regulation of exit from mitosis (GO:0007096)3.57111270
21autophagic vacuole fusion (GO:0000046)3.53431408
22positive regulation of leukocyte degranulation (GO:0043302)3.53267707
23negative regulation of reproductive process (GO:2000242)3.51449300
24mitotic metaphase plate congression (GO:0007080)3.50750198
25regulation of female receptivity (GO:0045924)3.50411308
26regulation of prostaglandin secretion (GO:0032306)3.48980238
27protein kinase C signaling (GO:0070528)3.48660341
28positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.37288810
29sleep (GO:0030431)3.33951435
30positive regulation of mast cell activation (GO:0033005)3.30790427
31developmental programmed cell death (GO:0010623)3.13059300
32meiotic cell cycle (GO:0051321)3.08010447
33drinking behavior (GO:0042756)3.04363551
34chaperone mediated protein folding requiring cofactor (GO:0051085)3.03462962
35regulation of retinoic acid receptor signaling pathway (GO:0048385)28.3815036
36DNA replication initiation (GO:0006270)2.99663199
37female mating behavior (GO:0060180)2.98669387
38positive regulation of humoral immune response (GO:0002922)2.97501328
39regulation of uterine smooth muscle contraction (GO:0070472)2.91769478
40CTP biosynthetic process (GO:0006241)2.90960115
41CTP metabolic process (GO:0046036)2.90960115
42maturation of SSU-rRNA (GO:0030490)2.90942252
43histamine transport (GO:0051608)2.90741342
44aggressive behavior (GO:0002118)2.85677529
45chromosome condensation (GO:0030261)2.84049960
46ribosome assembly (GO:0042255)2.83940573
47binding of sperm to zona pellucida (GO:0007339)2.82861409
48oocyte development (GO:0048599)2.82821998
49organelle membrane fusion (GO:0090174)2.81438322
50pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.80732563
51pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.80307842
52chaperone-mediated protein transport (GO:0072321)2.79970433
53protein localization to chromosome, centromeric region (GO:0071459)2.78178671
54piRNA metabolic process (GO:0034587)2.75647064
55metaphase plate congression (GO:0051310)2.73816627
56regulation of nucleobase-containing compound transport (GO:0032239)2.65789817
57snRNA transcription (GO:0009301)2.64537891
58positive regulation of protein homooligomerization (GO:0032464)2.62433429
59GTP biosynthetic process (GO:0006183)2.57648143
60viral transcription (GO:0019083)2.57286899
61formation of translation preinitiation complex (GO:0001731)2.53759869
62regulation of mast cell degranulation (GO:0043304)2.52742244
63regulation of spindle organization (GO:0090224)2.51290096
64regulation of mitotic spindle organization (GO:0060236)2.49960879
65translational termination (GO:0006415)2.49832024
66positive regulation of chromosome segregation (GO:0051984)2.49217423
67positive regulation of histone H3-K4 methylation (GO:0051571)2.48943831
68termination of RNA polymerase III transcription (GO:0006386)2.48889398
69transcription elongation from RNA polymerase III promoter (GO:0006385)2.48889398
70regulation of histone H3-K9 methylation (GO:0051570)2.48576077
71regulation of RNA export from nucleus (GO:0046831)2.48475648
72glycine transport (GO:0015816)2.48214580
73reproduction (GO:0000003)2.47879565
74regulation of mast cell activation involved in immune response (GO:0033006)2.47818290
75pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.46176005
76UTP biosynthetic process (GO:0006228)2.46049377
77establishment of chromosome localization (GO:0051303)2.45469154
78pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.45436272
79negative regulation of digestive system process (GO:0060457)2.44773941
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.43433429
81T cell costimulation (GO:0031295)2.41832076
82attachment of spindle microtubules to kinetochore (GO:0008608)2.39688197
83lymphocyte costimulation (GO:0031294)2.38872815
84positive regulation of digestive system process (GO:0060456)2.37347943
85male meiosis (GO:0007140)2.35843504
86regulation of penile erection (GO:0060405)2.35588529
87DNA replication-dependent nucleosome organization (GO:0034723)2.34933552
88DNA replication-dependent nucleosome assembly (GO:0006335)2.34933552
89ribosomal small subunit biogenesis (GO:0042274)2.34234251
90primitive streak formation (GO:0090009)2.33998015
91DNA replication checkpoint (GO:0000076)2.33120417
92translational initiation (GO:0006413)2.32740529
93righting reflex (GO:0060013)2.31339099
94mitotic sister chromatid segregation (GO:0000070)2.30099124
95telomere maintenance via telomere lengthening (GO:0010833)2.28781847
96response to acidic pH (GO:0010447)2.28386301
97positive regulation of icosanoid secretion (GO:0032305)2.28228482
98response to food (GO:0032094)2.27220260
99positive regulation of reproductive process (GO:2000243)2.26373473
100receptor catabolic process (GO:0032801)2.24083561

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.10389517
2E2F7_22180533_ChIP-Seq_HELA_Human5.34716458
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.15982645
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.46225347
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.34950308
6AR_21909140_ChIP-Seq_LNCAP_Human3.27916013
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.11053783
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.10064082
9EZH2_22144423_ChIP-Seq_EOC_Human3.01560572
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.94739760
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.80081346
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76010620
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.68818454
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58444876
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58444876
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58444876
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.55423091
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.53477184
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.51566290
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.43354972
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42938612
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.40041733
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37879538
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24097285
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14884512
26ELK1_19687146_ChIP-ChIP_HELA_Human2.03225048
27JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93858882
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.91500562
29ETV1_20927104_ChIP-Seq_GIST48_Human1.89458671
30RBPJ_21746931_ChIP-Seq_IB4_Human1.88125841
31TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87658279
32VDR_23849224_ChIP-Seq_CD4+_Human1.84046950
33GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.83813972
34NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66056715
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.62463912
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61440140
37MYC_18940864_ChIP-ChIP_HL60_Human1.61003155
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60543433
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58546644
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58272982
41CIITA_25753668_ChIP-Seq_RAJI_Human1.58111206
42NFYB_21822215_ChIP-Seq_K562_Human1.55964859
43TTF2_22483619_ChIP-Seq_HELA_Human1.55932312
44ZNF263_19887448_ChIP-Seq_K562_Human1.52808374
45TBL1_22424771_ChIP-Seq_293T_Human1.52543693
46FOXP3_21729870_ChIP-Seq_TREG_Human1.51125426
47PHF8_20622853_ChIP-Seq_HELA_Human1.49705008
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.49637033
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49277889
50XRN2_22483619_ChIP-Seq_HELA_Human1.38111094
51TFEB_21752829_ChIP-Seq_HELA_Human1.35536693
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35140879
53HNFA_21074721_ChIP-Seq_CACO-2_Human1.33350179
54SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.32728516
55CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.30225729
56ZNF274_21170338_ChIP-Seq_K562_Hela1.27697046
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25746704
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23729833
59PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.22327300
60ELK1_22589737_ChIP-Seq_MCF10A_Human1.20881329
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20595779
62PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16984056
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.16682593
64GABP_19822575_ChIP-Seq_HepG2_Human1.16627443
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.16274972
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11510225
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11099138
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.07228370
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.06580768
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.05581130
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.05146835
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04916206
73SOX2_21211035_ChIP-Seq_LN229_Human1.03725506
74HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.03362669
75KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03248730
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.03079769
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.02733584
78NFYA_21822215_ChIP-Seq_K562_Human1.02297924
79DCP1A_22483619_ChIP-Seq_HELA_Human1.01648192
80NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99410167
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95601034
82TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95314977
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94117089
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92568317
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92530252
86STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89206644
87STAT1_20625510_ChIP-Seq_HELA_Human0.89153620
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87574556
89LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86920764
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86890620
91RAC3_21632823_ChIP-Seq_H3396_Human0.86681319
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85080520
93CTCF_21964334_Chip-Seq_Bcells_Human0.84487207
94SALL4_22934838_ChIP-ChIP_CD34+_Human0.84186369
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83784930
96CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82362056
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80530421
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80446166
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77445420
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74989799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.19781510
2MP0005451_abnormal_body_composition5.13245856
3MP0001835_abnormal_antigen_presentation3.85849914
4MP0009379_abnormal_foot_pigmentation3.76549211
5MP0010307_abnormal_tumor_latency3.48173925
6MP0006292_abnormal_olfactory_placode3.22629675
7MP0001986_abnormal_taste_sensitivity3.06292440
8MP0003077_abnormal_cell_cycle3.00100337
9MP0003693_abnormal_embryo_hatching2.91413905
10MP0004957_abnormal_blastocyst_morpholog2.90978420
11MP0003111_abnormal_nucleus_morphology2.81917683
12MP0010094_abnormal_chromosome_stability2.60078460
13MP0008057_abnormal_DNA_replication2.48497289
14MP0002160_abnormal_reproductive_system2.47634485
15MP0000762_abnormal_tongue_morphology2.27456467
16MP0002277_abnormal_respiratory_mucosa2.15087088
17MP0003950_abnormal_plasma_membrane1.98989328
18MP0005408_hypopigmentation1.97963576
19MP0005395_other_phenotype1.94246620
20MP0002210_abnormal_sex_determination1.90836761
21MP0001929_abnormal_gametogenesis1.90256083
22MP0002233_abnormal_nose_morphology1.88470164
23MP0001881_abnormal_mammary_gland1.84978424
24MP0005499_abnormal_olfactory_system1.84214313
25MP0005394_taste/olfaction_phenotype1.84214313
26MP0005360_urolithiasis1.84119282
27MP0003699_abnormal_female_reproductive1.80913991
28MP0002396_abnormal_hematopoietic_system1.72294977
29MP0005423_abnormal_somatic_nervous1.70646995
30MP0005410_abnormal_fertilization1.69611748
31MP0001730_embryonic_growth_arrest1.68509099
32MP0009840_abnormal_foam_cell1.66021945
33MP0009333_abnormal_splenocyte_physiolog1.64277003
34MP0005389_reproductive_system_phenotype1.59157933
35MP0010368_abnormal_lymphatic_system1.53546140
36MP0002163_abnormal_gland_morphology1.39107461
37MP0008932_abnormal_embryonic_tissue1.38051420
38MP0000350_abnormal_cell_proliferation1.37626313
39MP0005380_embryogenesis_phenotype1.37451918
40MP0001672_abnormal_embryogenesis/_devel1.37451918
41MP0002127_abnormal_cardiovascular_syste1.36102741
42MP0005397_hematopoietic_system_phenotyp1.34998685
43MP0001545_abnormal_hematopoietic_system1.34998685
44MP0000627_abnormal_mammary_gland1.32979608
45MP0008058_abnormal_DNA_repair1.31873430
46MP0003252_abnormal_bile_duct1.29594325
47MP0002138_abnormal_hepatobiliary_system1.28025548
48MP0002161_abnormal_fertility/fecundity1.27554871
49MP0000653_abnormal_sex_gland1.27209731
50MP0009053_abnormal_anal_canal1.26168437
51MP0008260_abnormal_autophagy1.23779263
52MP0006276_abnormal_autonomic_nervous1.21608808
53MP0008007_abnormal_cellular_replicative1.19374930
54MP0001145_abnormal_male_reproductive1.15036544
55MP0002234_abnormal_pharynx_morphology1.11919370
56MP0010030_abnormal_orbit_morphology1.11239023
57MP0003984_embryonic_growth_retardation1.08040854
58MP0010352_gastrointestinal_tract_polyps1.07115969
59MP0005671_abnormal_response_to1.06593072
60MP0002080_prenatal_lethality1.06010001
61MP0008789_abnormal_olfactory_epithelium1.04614303
62MP0002896_abnormal_bone_mineralization1.03861163
63MP0001697_abnormal_embryo_size1.03486621
64MP0005647_abnormal_sex_gland1.03288125
65MP0002088_abnormal_embryonic_growth/wei0.97132134
66MP0001119_abnormal_female_reproductive0.96987959
67MP0006036_abnormal_mitochondrial_physio0.96553416
68MP0000358_abnormal_cell_content/0.95238900
69MP0003890_abnormal_embryonic-extraembry0.92087327
70MP0002269_muscular_atrophy0.91155775
71MP0002452_abnormal_antigen_presenting0.87801336
72MP0000313_abnormal_cell_death0.87454199
73MP0003698_abnormal_male_reproductive0.86871318
74MP0001666_abnormal_nutrient_absorption0.84551539
75MP0003868_abnormal_feces_composition0.81682349
76MP0003936_abnormal_reproductive_system0.80432942
77MP0004808_abnormal_hematopoietic_stem0.79324001
78MP0002086_abnormal_extraembryonic_tissu0.77648173
79MP0003755_abnormal_palate_morphology0.77527701
80MP0008877_abnormal_DNA_methylation0.76767466
81MP0002085_abnormal_embryonic_tissue0.76584262
82MP0000537_abnormal_urethra_morphology0.76363017
83MP0002084_abnormal_developmental_patter0.74490924
84MP0000465_gastrointestinal_hemorrhage0.72197769
85MP0001293_anophthalmia0.70904716
86MP0004142_abnormal_muscle_tone0.70806039
87MP0002139_abnormal_hepatobiliary_system0.70227414
88MP0001873_stomach_inflammation0.67909414
89MP0004233_abnormal_muscle_weight0.67253257
90MP0002169_no_abnormal_phenotype0.66648816
91MP0002873_normal_phenotype0.66370572
92MP0003959_abnormal_lean_body0.65743883
93MP0003879_abnormal_hair_cell0.65274666
94MP0001819_abnormal_immune_cell0.63322125
95MP0003646_muscle_fatigue0.59691171
96MP0000733_abnormal_muscle_development0.59659124
97MP0003186_abnormal_redox_activity0.58093520
98MP0003172_abnormal_lysosome_physiology0.57823531
99MP0005646_abnormal_pituitary_gland0.54289127
100MP0005319_abnormal_enzyme/_coenzyme0.53697183

Predicted human phenotypes

RankGene SetZ-score
1Obstructive lung disease (HP:0006536)6.55146186
2Chronic obstructive pulmonary disease (HP:0006510)6.55146186
3Ankyloglossia (HP:0010296)6.07050913
4Cerebral palsy (HP:0100021)5.97087582
5Absent/shortened dynein arms (HP:0200106)5.69501394
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.69501394
7Chin dimple (HP:0010751)5.32409319
8Hemoptysis (HP:0002105)5.31037383
9Male infertility (HP:0003251)4.83693283
10Abnormality of complement system (HP:0005339)4.75941417
11Abnormality of oral frenula (HP:0000190)4.53112359
12Glomerulopathy (HP:0100820)4.08532885
13Abnormality of the pericardium (HP:0001697)3.97002479
14Tetraparesis (HP:0002273)3.77223213
15Malnutrition (HP:0004395)3.74086371
16Abnormal ciliary motility (HP:0012262)3.48754064
17Nephritis (HP:0000123)3.48520865
18Acrocyanosis (HP:0001063)3.44149292
19Abnormality of the pleura (HP:0002103)3.41415200
20Skin rash (HP:0000988)3.35458820
21Multiple enchondromatosis (HP:0005701)3.08286578
22Neoplasm of the colon (HP:0100273)3.02593296
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.01676115
24Abnormality of the prostate (HP:0008775)2.95032224
25Reticulocytopenia (HP:0001896)2.93210482
26Abnormal respiratory motile cilium morphology (HP:0005938)2.92211815
27Abnormal respiratory epithelium morphology (HP:0012253)2.92211815
28Posterior subcapsular cataract (HP:0007787)2.91114576
29Short tibia (HP:0005736)2.88199265
30Gastrointestinal infarctions (HP:0005244)2.83883689
31Vasculitis (HP:0002633)2.83765318
32Amyloidosis (HP:0011034)2.83116641
33Birth length less than 3rd percentile (HP:0003561)2.82299640
34Premature ovarian failure (HP:0008209)2.80610225
35Restrictive lung disease (HP:0002091)2.80469832
36Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.77767637
37Short 1st metacarpal (HP:0010034)2.77767637
38Glossoptosis (HP:0000162)2.77094759
39Bifid uvula (HP:0000193)2.68511259
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68165646
41Pruritus (HP:0000989)2.67399698
42Ureteral stenosis (HP:0000071)2.65556058
43Hypercortisolism (HP:0001578)2.60454058
44Vertebral compression fractures (HP:0002953)2.60333878
45Constricted visual fields (HP:0001133)2.59893583
46Cerebellar dysplasia (HP:0007033)2.58553167
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.52864382
48Emphysema (HP:0002097)2.52159555
49Chromsome breakage (HP:0040012)2.48049205
50Paresthesia (HP:0003401)2.47914806
51Hematuria (HP:0000790)2.42628703
52Ureteral obstruction (HP:0006000)2.42442577
53Abnormality of the 1st metacarpal (HP:0010009)2.42437928
54Meningitis (HP:0001287)2.36021932
55Fibular aplasia (HP:0002990)2.33664992
56Abnormal respiratory motile cilium physiology (HP:0012261)2.28492966
57Aplasia/hypoplasia of the humerus (HP:0006507)2.28411570
58Distal lower limb amyotrophy (HP:0008944)2.23930437
59Mesomelia (HP:0003027)2.23536084
60Severe muscular hypotonia (HP:0006829)2.20535299
61Muscle stiffness (HP:0003552)2.15073756
62Facial cleft (HP:0002006)2.09494515
63Pulmonary fibrosis (HP:0002206)2.05294763
64Abnormality of proline metabolism (HP:0010907)2.04558039
65Hydroxyprolinuria (HP:0003080)2.04558039
66Subcapsular cataract (HP:0000523)2.03507067
67Hypoproteinemia (HP:0003075)2.03047205
68Abnormality of binocular vision (HP:0011514)2.03012281
69Diplopia (HP:0000651)2.03012281
70Amaurosis fugax (HP:0100576)2.02875776
71Carpal bone hypoplasia (HP:0001498)2.02783781
72Patent foramen ovale (HP:0001655)2.01310909
73Ulnar deviation of finger (HP:0009465)1.98648843
74Trismus (HP:0000211)1.98423110
75Progressive sensorineural hearing impairment (HP:0000408)1.98392850
76Sensory axonal neuropathy (HP:0003390)1.94474640
77Abnormality of male internal genitalia (HP:0000022)1.93536132
78Gangrene (HP:0100758)1.92373569
79Steatorrhea (HP:0002570)1.89380745
80Infertility (HP:0000789)1.86738051
81Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.86324942
82Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.85612181
83Short humerus (HP:0005792)1.82478814
84Fatigue (HP:0012378)1.81855061
85Abnormal umbilical cord blood vessels (HP:0011403)1.81733753
86Single umbilical artery (HP:0001195)1.81733753
87Abnormality of the fetal cardiovascular system (HP:0010948)1.81733753
88Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.78354479
89Degeneration of the lateral corticospinal tracts (HP:0002314)1.78354479
90Progressive hearing impairment (HP:0001730)1.77524508
91Aplastic anemia (HP:0001915)1.73363830
92Radial bowing (HP:0002986)1.72414908
93Mitral stenosis (HP:0001718)1.71082041
94Lymphoma (HP:0002665)1.69064449
95Impulsivity (HP:0100710)1.67448980
96Recurrent sinusitis (HP:0011108)1.65382991
97Hypophosphatemic rickets (HP:0004912)1.64382820
98Hypergonadotropic hypogonadism (HP:0000815)1.63713492
99Ascites (HP:0001541)1.62162660
100Ependymoma (HP:0002888)1.60690934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.39933065
2BUB14.79649069
3STK163.99679112
4SCYL23.69106967
5TESK23.48965007
6MAP3K122.87641263
7TLK12.62286453
8PBK2.61059098
9RIPK12.54811866
10EIF2AK32.44018073
11MAP3K92.33619966
12SRPK12.30893085
13LATS22.19155210
14BRSK22.10459727
15MAP3K131.96007595
16EIF2AK11.94264858
17NEK61.84929002
18CDK81.79660518
19NEK21.70971354
20BRSK11.69155868
21AURKA1.68900654
22NME21.63525003
23CDC71.62521672
24CDK121.60367927
25TAOK21.51883882
26IRAK31.45544335
27ZAK1.41555252
28BMPR21.41086920
29AURKB1.37776390
30PLK11.31648535
31PAK61.31306941
32CDK91.28697376
33ILK1.26456808
34PAK41.25090908
35CDK71.20979592
36MYLK1.18126425
37PKN11.13655713
38TRIM281.10959063
39MELK1.08151504
40CHEK20.99773287
41MARK30.98530158
42MAP3K140.94209444
43BMPR1B0.90075565
44DAPK10.90043915
45TTK0.87341168
46PRKCI0.85672786
47MET0.85031238
48MOS0.85016611
49PLK30.84346376
50MAP3K50.80738344
51PAK10.77895643
52CHEK10.76226648
53ARAF0.76200236
54STK240.73473315
55MAP3K80.72773872
56PAK20.70966435
57PIM10.68321065
58FLT30.67969115
59STK40.65845496
60DYRK30.65001082
61JAK30.63838356
62PRPF4B0.60007554
63CSNK2A20.58979433
64NEK10.51107764
65CSNK2A10.51072862
66RAF10.50944754
67CDK10.49430852
68WEE10.48837487
69GSK3A0.48029711
70CSNK1E0.47992884
71VRK10.47741744
72PTK20.46867894
73CDK20.45785299
74MTOR0.44104286
75AKT20.43771134
76STK30.42890031
77DAPK30.41418429
78ATR0.40566708
79PLK40.38889171
80TAOK30.37469337
81ATM0.36466072
82LRRK20.35038953
83ERBB40.33308136
84STK100.28147655
85DMPK0.27886651
86ABL20.27207221
87NEK90.25848254
88CLK10.24761732
89KSR20.24051351
90EIF2AK20.23013669
91TTN0.22876814
92RPS6KA50.22389056
93MAPK110.22306217
94TSSK60.22264073
95CDK11A0.21282973
96IRAK20.20703241
97PIM20.20343885
98IKBKB0.16035518
99RPS6KA40.15975292
100ALK0.15507264

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.61605880
2Allograft rejection_Homo sapiens_hsa053304.48631706
3Autoimmune thyroid disease_Homo sapiens_hsa053204.28909812
4Graft-versus-host disease_Homo sapiens_hsa053324.20517455
5Type I diabetes mellitus_Homo sapiens_hsa049403.53842579
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.49672329
7Basal transcription factors_Homo sapiens_hsa030222.96443126
8Viral myocarditis_Homo sapiens_hsa054162.86327608
9Staphylococcus aureus infection_Homo sapiens_hsa051502.67694217
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.51573696
11Antigen processing and presentation_Homo sapiens_hsa046122.47035185
12Systemic lupus erythematosus_Homo sapiens_hsa053222.38565414
13Cell cycle_Homo sapiens_hsa041102.22112681
14RNA polymerase_Homo sapiens_hsa030202.16912747
15Leishmaniasis_Homo sapiens_hsa051402.16144517
16Ribosome_Homo sapiens_hsa030102.15903047
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11400077
18Rheumatoid arthritis_Homo sapiens_hsa053232.04487292
19Regulation of autophagy_Homo sapiens_hsa041402.01103453
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97211664
21RNA transport_Homo sapiens_hsa030131.48265945
22mRNA surveillance pathway_Homo sapiens_hsa030151.47077251
23Herpes simplex infection_Homo sapiens_hsa051681.45989242
24DNA replication_Homo sapiens_hsa030301.45711256
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39286370
26Folate biosynthesis_Homo sapiens_hsa007901.38474438
27Oocyte meiosis_Homo sapiens_hsa041141.36538829
28Spliceosome_Homo sapiens_hsa030401.30199282
29Epstein-Barr virus infection_Homo sapiens_hsa051691.24669672
30Phagosome_Homo sapiens_hsa041451.21550788
31Pyrimidine metabolism_Homo sapiens_hsa002401.20219748
32Toxoplasmosis_Homo sapiens_hsa051451.19620895
33p53 signaling pathway_Homo sapiens_hsa041151.15003082
34Influenza A_Homo sapiens_hsa051641.13951443
35Proteasome_Homo sapiens_hsa030501.08066657
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07292783
37Mismatch repair_Homo sapiens_hsa034301.04686155
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95896388
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92395098
40Tuberculosis_Homo sapiens_hsa051520.90479247
41Base excision repair_Homo sapiens_hsa034100.89333985
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86322492
43Sulfur metabolism_Homo sapiens_hsa009200.85040191
44HTLV-I infection_Homo sapiens_hsa051660.81309066
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72677607
46Viral carcinogenesis_Homo sapiens_hsa052030.71825119
47Nucleotide excision repair_Homo sapiens_hsa034200.67865073
48Non-homologous end-joining_Homo sapiens_hsa034500.61641185
49Alcoholism_Homo sapiens_hsa050340.58623215
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58529212
51RNA degradation_Homo sapiens_hsa030180.54183754
52Ovarian steroidogenesis_Homo sapiens_hsa049130.48981266
53Taste transduction_Homo sapiens_hsa047420.47092289
54Protein export_Homo sapiens_hsa030600.46292472
55Olfactory transduction_Homo sapiens_hsa047400.44463655
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42444135
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.39777485
58Huntingtons disease_Homo sapiens_hsa050160.39436907
59Fanconi anemia pathway_Homo sapiens_hsa034600.39224642
60African trypanosomiasis_Homo sapiens_hsa051430.34443588
61Purine metabolism_Homo sapiens_hsa002300.34433878
62Shigellosis_Homo sapiens_hsa051310.31459548
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28732443
64Dorso-ventral axis formation_Homo sapiens_hsa043200.25966454
65Cardiac muscle contraction_Homo sapiens_hsa042600.25777477
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25696619
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22848264
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.22390635
69MicroRNAs in cancer_Homo sapiens_hsa052060.21689667
70Legionellosis_Homo sapiens_hsa051340.19577366
71Hepatitis B_Homo sapiens_hsa051610.18325333
72Fatty acid biosynthesis_Homo sapiens_hsa000610.16535822
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16415146
74Parkinsons disease_Homo sapiens_hsa050120.15925085
75Arginine and proline metabolism_Homo sapiens_hsa003300.15356870
76N-Glycan biosynthesis_Homo sapiens_hsa005100.13219189
77Caffeine metabolism_Homo sapiens_hsa002320.13104170
78Small cell lung cancer_Homo sapiens_hsa052220.10154781
79Chemokine signaling pathway_Homo sapiens_hsa040620.07977380
80TGF-beta signaling pathway_Homo sapiens_hsa043500.07248595
81Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.04505162
82Inositol phosphate metabolism_Homo sapiens_hsa005620.04034567
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03899992
84Homologous recombination_Homo sapiens_hsa034400.03142136
85Glutathione metabolism_Homo sapiens_hsa004800.02859684
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.00032692
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0784077
88Complement and coagulation cascades_Homo sapiens_hsa04610-0.0768644
89Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0746455
90Regulation of actin cytoskeleton_Homo sapiens_hsa04810-0.0698061
91Vibrio cholerae infection_Homo sapiens_hsa05110-0.0675288
92Histidine metabolism_Homo sapiens_hsa00340-0.0594707
93Oxidative phosphorylation_Homo sapiens_hsa00190-0.0570121
94Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0278350
95NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.0222546
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0178271
97Hippo signaling pathway_Homo sapiens_hsa04390-0.0169999
98FoxO signaling pathway_Homo sapiens_hsa04068-0.0114649
99Acute myeloid leukemia_Homo sapiens_hsa05221-0.0043071
100Thyroid cancer_Homo sapiens_hsa05216-0.0025357

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