ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	opioid receptor signaling pathway (GO:0038003)	8.18536628
2	histamine secretion (GO:0001821)	6.67929554
3	adenosine receptor signaling pathway (GO:0001973)	5.37975730
4	positive regulation of mast cell activation involved in immune response (GO:0033008)	5.34555683
5	positive regulation of mast cell degranulation (GO:0043306)	5.34555683
6	histamine transport (GO:0051608)	5.21250498
7	positive regulation of prostaglandin secretion (GO:0032308)	5.09184373
8	apoptotic DNA fragmentation (GO:0006309)	4.73579448
9	viral transcription (GO:0019083)	4.71316914
10	translational termination (GO:0006415)	4.49711925
11	positive regulation of protein homooligomerization (GO:0032464)	4.45799136
12	regulation of prostaglandin secretion (GO:0032306)	4.40514831
13	autophagic vacuole fusion (GO:0000046)	4.40238653
14	regulation of acrosome reaction (GO:0060046)	4.39139928
15	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.30357797
16	GTP biosynthetic process (GO:0006183)	4.29979060
17	regulation of female gonad development (GO:2000194)	4.28508295
18	behavioral response to ethanol (GO:0048149)	4.24292873
19	CTP metabolic process (GO:0046036)	4.23403391
20	CTP biosynthetic process (GO:0006241)	4.23403391
21	aggressive behavior (GO:0002118)	4.16531604
22	positive regulation of fatty acid transport (GO:2000193)	4.15632734
23	positive regulation of mast cell activation (GO:0033005)	4.15356668
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.01701051
25	maturation of SSU-rRNA (GO:0030490)	4.00139907
26	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.96197494
27	cotranslational protein targeting to membrane (GO:0006613)	3.96167615
28	developmental programmed cell death (GO:0010623)	3.95309984
29	UTP biosynthetic process (GO:0006228)	3.91803535
30	protein targeting to ER (GO:0045047)	3.90295492
31	response to gravity (GO:0009629)	3.86455186
32	positive regulation of icosanoid secretion (GO:0032305)	3.85298012
33	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	3.84757297
34	adult feeding behavior (GO:0008343)	3.84206818
35	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.83442512
36	translational elongation (GO:0006414)	3.80931320
37	T cell costimulation (GO:0031295)	3.74077840
38	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.73675534
39	lymphocyte costimulation (GO:0031294)	3.69483964
40	defense response to protozoan (GO:0042832)	3.68476282
41	righting reflex (GO:0060013)	3.68190003
42	positive regulation of leukocyte degranulation (GO:0043302)	3.67909860
43	response to pheromone (GO:0019236)	3.65702055
44	protein localization to endoplasmic reticulum (GO:0070972)	3.61630145
45	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.56834517
46	drinking behavior (GO:0042756)	3.56440185
47	regulation of female receptivity (GO:0045924)	3.49944738
48	positive regulation of T cell differentiation in thymus (GO:0033089)	3.43487725
49	endoderm development (GO:0007492)	3.43279847
50	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.42075730
51	lymph node development (GO:0048535)	3.39290641
52	UTP metabolic process (GO:0046051)	3.38696207
53	cellular protein complex disassembly (GO:0043624)	3.38664689
54	release of sequestered calcium ion into cytosol (GO:0051209)	3.36465075
55	negative regulation of sequestering of calcium ion (GO:0051283)	3.36465075
56	negative regulation of B cell proliferation (GO:0030889)	3.34143640
57	negative regulation of reproductive process (GO:2000242)	3.33098461
58	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.28992017
59	ribosomal small subunit biogenesis (GO:0042274)	3.28814232
60	ribosomal small subunit assembly (GO:0000028)	3.26897397
61	piRNA metabolic process (GO:0034587)	3.21148483
62	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	3.20383213
63	regulation of uterine smooth muscle contraction (GO:0070472)	3.18122050
64	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.16732639
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.16732639
66	regulation of mast cell degranulation (GO:0043304)	3.16128385
67	DNA deamination (GO:0045006)	3.15610689
68	NIK/NF-kappaB signaling (GO:0038061)	3.14131691
69	guanosine-containing compound biosynthetic process (GO:1901070)	3.10928982
70	multicellular organism reproduction (GO:0032504)	3.08315085
71	regulation of sequestering of calcium ion (GO:0051282)	3.07573802
72	interferon-gamma-mediated signaling pathway (GO:0060333)	3.07233571
73	response to protozoan (GO:0001562)	3.06835604
74	translational initiation (GO:0006413)	3.03986251
75	viral life cycle (GO:0019058)	3.02748092
76	regulation of mast cell activation involved in immune response (GO:0033006)	3.02702782
77	chemokine-mediated signaling pathway (GO:0070098)	3.02521529
78	organelle membrane fusion (GO:0090174)	3.02452588
79	regulation of icosanoid secretion (GO:0032303)	3.01585639
80	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	22.0783429
81	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.98813160
82	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.97332733
83	preassembly of GPI anchor in ER membrane (GO:0016254)	2.95645862
84	female mating behavior (GO:0060180)	2.87833792
85	negative regulation of alpha-beta T cell activation (GO:0046636)	2.81634590
86	peptidyl-histidine modification (GO:0018202)	2.79463250
87	regulation of alpha-beta T cell proliferation (GO:0046640)	2.78236786
88	azole transport (GO:0045117)	2.77542101
89	GPI anchor metabolic process (GO:0006505)	2.77279222
90	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	2.76222489
91	positive regulation of organic acid transport (GO:0032892)	2.73565001
92	T cell receptor signaling pathway (GO:0050852)	2.73065950
93	sleep (GO:0030431)	2.72724990
94	regulation of response to tumor cell (GO:0002834)	2.72371919
95	positive regulation of response to tumor cell (GO:0002836)	2.72371919
96	positive regulation of immune response to tumor cell (GO:0002839)	2.72371919
97	regulation of immune response to tumor cell (GO:0002837)	2.72371919
98	positive regulation of humoral immune response (GO:0002922)	2.72213488
99	receptor catabolic process (GO:0032801)	2.70645816
100	regulation of retinoic acid receptor signaling pathway (GO:0048385)	18.4047211

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	5.29030370
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.28833696
3	IRF8_21731497_ChIP-ChIP_J774_Mouse	4.10234074
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.02410361
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.93140421
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.88115874
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.72026495
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.45685484
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.40316415
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.37786670
11	NANOG_19829295_ChIP-Seq_ESCs_Human	2.34889261
12	SOX2_19829295_ChIP-Seq_ESCs_Human	2.34889261
13	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31655254
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.17273662
15	SOX2_21211035_ChIP-Seq_LN229_Human	2.16271663
16	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	2.07168656
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03299782
18	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	2.01451375
19	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.00646635
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98020333
21	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.90569259
22	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.84251297
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.82421861
24	ETV1_20927104_ChIP-Seq_GIST48_Human	1.79504951
25	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.75708854
26	NFYB_21822215_ChIP-Seq_K562_Human	1.71494216
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69744815
28	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.69277814
29	AR_25329375_ChIP-Seq_VCAP_Human	1.68355056
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.67745966
31	AR_20517297_ChIP-Seq_VCAP_Human	1.66819525
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.64603974
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.63531754
34	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.62733349
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.58890069
36	RBPJ_21746931_ChIP-Seq_IB4_Human	1.54348764
37	PHF8_20622853_ChIP-Seq_HELA_Human	1.52779621
38	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.52695396
39	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.51908973
40	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.50759085
41	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.49334789
42	TBL1_22424771_ChIP-Seq_293T_Human	1.48414095
43	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.46285869
44	RUNX_20019798_ChIP-Seq_JUKART_Human	1.45914566
45	SALL4_22934838_ChIP-ChIP_CD34+_Human	1.43676295
46	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.42503708
47	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.40143665
48	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.38602557
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.38153861
50	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.38052489
51	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.37818661
52	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.37556967
53	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	1.35990335
54	VDR_22108803_ChIP-Seq_LS180_Human	1.35436208
55	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35077044
56	NFYA_21822215_ChIP-Seq_K562_Human	1.33542195
57	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.33206984
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.32022870
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.32022870
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.31889185
61	NANOG_20526341_ChIP-Seq_ESCs_Human	1.31436504
62	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.31400052
63	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.31255278
64	EGR1_19032775_ChIP-ChIP_M12_Human	1.29789164
65	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.29504835
66	TAF15_26573619_Chip-Seq_HEK293_Human	1.29253302
67	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.26202859
68	VDR_23849224_ChIP-Seq_CD4+_Human	1.26036095
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25645115
70	TP53_22573176_ChIP-Seq_HFKS_Human	1.22745347
71	RAC3_21632823_ChIP-Seq_H3396_Human	1.22323557
72	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.19763125
73	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.19657645
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18861054
75	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.18082222
76	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.18070439
77	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.17719212
78	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.17475887
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16491859
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16242677
81	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13510198
82	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.12837826
83	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.12837826
84	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10209982
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.08617515
86	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.06612931
87	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.05830953
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04048320
89	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.02884921
90	GATA3_26560356_Chip-Seq_TH2_Human	1.01951064
91	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.00050636
92	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.96959744
93	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94370028
94	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.93914295
95	EWS_26573619_Chip-Seq_HEK293_Human	0.92330052
96	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.92159198
97	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.91954794
98	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91123214
99	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89405745
100	ER_23166858_ChIP-Seq_MCF-7_Human	0.88703030

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	5.75476480
2	MP0005671_abnormal_response_to	3.95611801
3	MP0009379_abnormal_foot_pigmentation	3.75938150
4	MP0005451_abnormal_body_composition	3.58735840
5	MP0001986_abnormal_taste_sensitivity	3.53709942
6	MP0002277_abnormal_respiratory_mucosa	3.15451356
7	MP0003011_delayed_dark_adaptation	3.10293734
8	MP0000372_irregular_coat_pigmentation	2.95463264
9	MP0003136_yellow_coat_color	2.89344147
10	MP0010307_abnormal_tumor_latency	2.47701129
11	MP0000762_abnormal_tongue_morphology	2.47500784
12	MP0003718_maternal_effect	2.31629295
13	MP0005423_abnormal_somatic_nervous	2.10112553
14	MP0001968_abnormal_touch/_nociception	2.04425909
15	MP0006072_abnormal_retinal_apoptosis	1.91084149
16	MP0002163_abnormal_gland_morphology	1.90940209
17	MP0002160_abnormal_reproductive_system	1.89803427
18	MP0005253_abnormal_eye_physiology	1.88825527
19	MP0002736_abnormal_nociception_after	1.85365870
20	MP0003646_muscle_fatigue	1.78883094
21	MP0003866_abnormal_defecation	1.70826406
22	MP0005646_abnormal_pituitary_gland	1.65862538
23	MP0005551_abnormal_eye_electrophysiolog	1.63245997
24	MP0005408_hypopigmentation	1.58239388
25	MP0002734_abnormal_mechanical_nocicepti	1.56558154
26	MP0002233_abnormal_nose_morphology	1.50431077
27	MP0004272_abnormal_basement_membrane	1.48317027
28	MP0002396_abnormal_hematopoietic_system	1.45055775
29	MP0003045_fibrosis	1.41661222
30	MP0005360_urolithiasis	1.41027005
31	MP0009053_abnormal_anal_canal	1.40892385
32	MP0002452_abnormal_antigen_presenting	1.37911075
33	MP0005389_reproductive_system_phenotype	1.37711165
34	MP0008438_abnormal_cutaneous_collagen	1.37023026
35	MP0001819_abnormal_immune_cell	1.36349428
36	MP0001529_abnormal_vocalization	1.32339764
37	MP0008995_early_reproductive_senescence	1.28983769
38	MP0006082_CNS_inflammation	1.26255740
39	MP0005410_abnormal_fertilization	1.22372665
40	MP0000685_abnormal_immune_system	1.22057382
41	MP0002210_abnormal_sex_determination	1.20223169
42	MP0005395_other_phenotype	1.18080111
43	MP0000631_abnormal_neuroendocrine_gland	1.16261248
44	MP0002896_abnormal_bone_mineralization	1.15520996
45	MP0001800_abnormal_humoral_immune	1.15005387
46	MP0003195_calcinosis	1.14721127
47	MP0004019_abnormal_vitamin_homeostasis	1.13562538
48	MP0010368_abnormal_lymphatic_system	1.13317543
49	MP0001873_stomach_inflammation	1.12723548
50	MP0008004_abnormal_stomach_pH	1.12596014
51	MP0005000_abnormal_immune_tolerance	1.10523048
52	MP0003699_abnormal_female_reproductive	1.04604212
53	MP0004142_abnormal_muscle_tone	1.04469975
54	MP0003763_abnormal_thymus_physiology	1.04360119
55	MP0005367_renal/urinary_system_phenotyp	1.02577304
56	MP0000516_abnormal_urinary_system	1.02577304
57	MP0003950_abnormal_plasma_membrane	1.01810505
58	MP0001929_abnormal_gametogenesis	1.01172229
59	MP0003936_abnormal_reproductive_system	0.99605452
60	MP0005391_vision/eye_phenotype	0.98926780
61	MP0002723_abnormal_immune_serum	0.96169512
62	MP0001881_abnormal_mammary_gland	0.95858023
63	MP0002420_abnormal_adaptive_immunity	0.93941904
64	MP0005448_abnormal_energy_balance	0.93752994
65	MP0000534_abnormal_ureter_morphology	0.89400037
66	MP0009384_cardiac_valve_regurgitation	0.89394236
67	MP0001944_abnormal_pancreas_morphology	0.89024930
68	MP0000653_abnormal_sex_gland	0.88779024
69	MP0002127_abnormal_cardiovascular_syste	0.88099891
70	MP0001145_abnormal_male_reproductive	0.87578430
71	MP0006292_abnormal_olfactory_placode	0.85859910
72	MP0006276_abnormal_autonomic_nervous	0.84414593
73	MP0003283_abnormal_digestive_organ	0.82299852
74	MP0008874_decreased_physiological_sensi	0.82209782
75	MP0009764_decreased_sensitivity_to	0.80338589
76	MP0005503_abnormal_tendon_morphology	0.79805812
77	MP0003172_abnormal_lysosome_physiology	0.78658123
78	MP0004084_abnormal_cardiac_muscle	0.78241886
79	MP0002132_abnormal_respiratory_system	0.77865447
80	MP0001119_abnormal_female_reproductive	0.77583839
81	MP0001664_abnormal_digestion	0.77278395
82	MP0003252_abnormal_bile_duct	0.76682580
83	MP0000920_abnormal_myelination	0.76610089
84	MP0003755_abnormal_palate_morphology	0.72465354
85	MP0000049_abnormal_middle_ear	0.71486587
86	MP0000639_abnormal_adrenal_gland	0.71290265
87	MP0000716_abnormal_immune_system	0.71046831
88	MP0002234_abnormal_pharynx_morphology	0.70166982
89	MP0002405_respiratory_system_inflammati	0.69013796
90	MP0000538_abnormal_urinary_bladder	0.68929166
91	MP0002398_abnormal_bone_marrow	0.67786452
92	MP0002148_abnormal_hypersensitivity_rea	0.67760211
93	MP0002282_abnormal_trachea_morphology	0.67397987
94	MP0001440_abnormal_grooming_behavior	0.67322434
95	MP0003959_abnormal_lean_body	0.66281713
96	MP0005275_abnormal_skin_tensile	0.64379620
97	MP0000013_abnormal_adipose_tissue	0.61921918
98	MP0005075_abnormal_melanosome_morpholog	0.61917618
99	MP0002928_abnormal_bile_duct	0.61468877
100	MP0000627_abnormal_mammary_gland	0.61214026

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cerebral palsy (HP:0100021)	8.12599007
2	Chronic obstructive pulmonary disease (HP:0006510)	6.79885254
3	Obstructive lung disease (HP:0006536)	6.79885254
4	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.20131228
5	Absent/shortened dynein arms (HP:0200106)	6.20131228
6	Chin dimple (HP:0010751)	6.00627004
7	Hemoptysis (HP:0002105)	5.38291887
8	Ankyloglossia (HP:0010296)	4.86787100
9	Abnormality of complement system (HP:0005339)	4.67813719
10	Abnormal ciliary motility (HP:0012262)	4.30402551
11	Hypoproteinemia (HP:0003075)	3.96733139
12	Abnormality of the pericardium (HP:0001697)	3.85635591
13	Abnormality of the pleura (HP:0002103)	3.78741495
14	Glomerulopathy (HP:0100820)	3.77203863
15	Acrocyanosis (HP:0001063)	3.66225671
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.61081768
17	Abnormal respiratory motile cilium morphology (HP:0005938)	3.61081768
18	Abnormal respiratory motile cilium physiology (HP:0012261)	3.57537062
19	Nephritis (HP:0000123)	3.53455538
20	Abnormality of oral frenula (HP:0000190)	3.42365934
21	Abnormality of binocular vision (HP:0011514)	3.31414883
22	Diplopia (HP:0000651)	3.31414883
23	Mesomelia (HP:0003027)	3.28211918
24	Reticulocytopenia (HP:0001896)	3.27752502
25	Constricted visual fields (HP:0001133)	3.26450900
26	Vasculitis (HP:0002633)	3.22990550
27	Skin rash (HP:0000988)	3.18756550
28	Restrictive lung disease (HP:0002091)	3.16857174
29	Hydroxyprolinuria (HP:0003080)	3.15832953
30	Abnormality of proline metabolism (HP:0010907)	3.15832953
31	Hypoplasia of the pons (HP:0012110)	3.14573557
32	Cerebellar dysplasia (HP:0007033)	3.14481418
33	Abnormality of the pons (HP:0007361)	3.03899682
34	Meningitis (HP:0001287)	2.97276883
35	Gastrointestinal infarctions (HP:0005244)	2.96479601
36	Ureteral stenosis (HP:0000071)	2.95675857
37	Exertional dyspnea (HP:0002875)	2.91462126
38	Tetraparesis (HP:0002273)	2.90794921
39	Type II lissencephaly (HP:0007260)	2.89616838
40	Emphysema (HP:0002097)	2.84654506
41	Type 2 muscle fiber atrophy (HP:0003554)	2.73863646
42	Dyschromatopsia (HP:0007641)	2.63977214
43	Severe muscular hypotonia (HP:0006829)	2.60712916
44	Ureteral obstruction (HP:0006000)	2.57741742
45	Abnormality of the prostate (HP:0008775)	2.55769735
46	Pruritus (HP:0000989)	2.54448433
47	Central scotoma (HP:0000603)	2.53823660
48	Neoplasm of the colon (HP:0100273)	2.52507672
49	Increased hepatocellular lipid droplets (HP:0006565)	2.44822516
50	Radial bowing (HP:0002986)	2.44003608
51	Paresthesia (HP:0003401)	2.41820721
52	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.30610198
53	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.24748108
54	Short 1st metacarpal (HP:0010034)	2.24748108
55	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	2.18766482
56	Muscle fiber atrophy (HP:0100295)	2.18356010
57	Enlarged epiphyses (HP:0010580)	2.17424688
58	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.15914591
59	Thyroid-stimulating hormone excess (HP:0002925)	2.14765996
60	Short tibia (HP:0005736)	2.10355717
61	Bifid uvula (HP:0000193)	2.07099447
62	Fibular hypoplasia (HP:0003038)	2.06373360
63	Hyperlipoproteinemia (HP:0010980)	2.05628229
64	Hematuria (HP:0000790)	2.05091399
65	Oligomenorrhea (HP:0000876)	2.03957348
66	Vertebral compression fractures (HP:0002953)	2.03142715
67	Abnormality of the 1st metacarpal (HP:0010009)	2.00926278
68	Recurrent sinusitis (HP:0011108)	2.00678833
69	Abnormality of cells of the erythroid lineage (HP:0012130)	1.98373577
70	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96858634
71	Patent foramen ovale (HP:0001655)	1.95192330
72	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.92438095
73	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.91139579
74	Abnormal number of erythroid precursors (HP:0012131)	1.88575625
75	Lipid accumulation in hepatocytes (HP:0006561)	1.87006355
76	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.86333858
77	Chronic mucocutaneous candidiasis (HP:0002728)	1.86139074
78	Recurrent cutaneous fungal infections (HP:0011370)	1.86139074
79	Abnormality of male internal genitalia (HP:0000022)	1.84145732
80	Fibular aplasia (HP:0002990)	1.83484585
81	Median cleft lip (HP:0000161)	1.77989079
82	Renal Fanconi syndrome (HP:0001994)	1.77546121
83	Abnormality of the renal collecting system (HP:0004742)	1.77445209
84	Posterior subcapsular cataract (HP:0007787)	1.75783463
85	Short phalanx of the thumb (HP:0009660)	1.74867027
86	Duplicated collecting system (HP:0000081)	1.74774120
87	Opisthotonus (HP:0002179)	1.73771272
88	3-Methylglutaconic aciduria (HP:0003535)	1.73629198
89	Ulnar deviation of finger (HP:0009465)	1.73464031
90	Gangrene (HP:0100758)	1.73266347
91	Abnormality of the vitreous humor (HP:0004327)	1.71140963
92	Synostosis involving the elbow (HP:0003938)	1.70073421
93	Humeroradial synostosis (HP:0003041)	1.70073421
94	Pulmonary fibrosis (HP:0002206)	1.68897106
95	Abnormal rod and cone electroretinograms (HP:0008323)	1.68035366
96	Male infertility (HP:0003251)	1.64363045
97	Hypercortisolism (HP:0001578)	1.63718613
98	Pallor (HP:0000980)	1.59476227
99	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.56829123
100	Respiratory difficulties (HP:0002880)	1.55275526

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	6.57115396
2	STK16	3.22793176
3	RIPK1	2.86458343
4	KDR	2.76544202
5	EPHB1	2.75617090
6	MAPK15	2.63598655
7	TLK1	2.63247889
8	EIF2AK3	2.54879714
9	BMPR1B	2.49006947
10	MAP3K11	2.46663332
11	CDK8	2.15875692
12	BUB1	2.10070954
13	VRK2	1.94070507
14	RIPK4	1.88076503
15	TESK2	1.87853379
16	TAF1	1.79172514
17	BMPR2	1.71616072
18	IRAK1	1.70189352
19	FRK	1.63521020
20	EPHA3	1.53754863
21	PKN1	1.53511212
22	NME1	1.53025831
23	FLT3	1.52798737
24	PNCK	1.46706162
25	DAPK1	1.46175237
26	VRK1	1.44469793
27	BRSK2	1.43107355
28	BCKDK	1.39428744
29	SCYL2	1.38606657
30	AURKA	1.38395142
31	MELK	1.35394569
32	MAP3K12	1.33972987
33	MYLK	1.25850150
34	DYRK3	1.22829002
35	MAP3K14	1.16659503
36	WEE1	1.15487959
37	HIPK2	1.10560653
38	ADRBK2	1.10426599
39	MAP3K5	1.04902370
40	TAOK2	1.04602963
41	OXSR1	1.03573836
42	FES	1.00204539
43	MAP4K1	0.95821593
44	DAPK3	0.91054718
45	DAPK2	0.90146549
46	NEK9	0.89063271
47	DYRK2	0.85399606
48	TIE1	0.81671296
49	CAMK1	0.81431601
50	ILK	0.71487804
51	EIF2AK2	0.70643184
52	RPS6KA5	0.70224786
53	NEK2	0.68769682
54	MAP3K3	0.66864743
55	BRSK1	0.66738202
56	BLK	0.66606434
57	MAP3K2	0.65206591
58	PRKCE	0.64656817
59	ITK	0.64257800
60	CSNK2A2	0.63933993
61	TGFBR1	0.60656398
62	NEK6	0.59726128
63	IKBKB	0.58720442
64	EPHA4	0.58708253
65	PRKCI	0.58167374
66	STK4	0.52684782
67	ZAK	0.51444995
68	CSNK2A1	0.51287486
69	PIM1	0.50888137
70	PDK1	0.50260829
71	CSNK1A1L	0.50236881
72	JAK3	0.50065385
73	ADRBK1	0.48657236
74	CDK9	0.48257696
75	MARK3	0.45987299
76	RET	0.44108537
77	JAK1	0.42933533
78	SYK	0.40714048
79	CAMK4	0.40630012
80	NME2	0.38870268
81	AURKB	0.38845507
82	PDPK1	0.37960803
83	BRD4	0.37925287
84	NLK	0.37714523
85	GRK1	0.37195255
86	GSK3A	0.35896764
87	RPS6KB1	0.35683818
88	ERBB4	0.34946660
89	ERN1	0.34594083
90	IRAK3	0.34506437
91	KIT	0.34088640
92	CDK3	0.34035816
93	DDR2	0.33921515
94	MAP3K13	0.31748541
95	TRPM7	0.30282989
96	EGFR	0.30134333
97	ALK	0.28434277
98	MAPK13	0.28193220
99	CHEK2	0.27378491
100	PAK2	0.26491790

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.71377921
2	Allograft rejection_Homo sapiens_hsa05330	5.40062998
3	Graft-versus-host disease_Homo sapiens_hsa05332	4.74483741
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.71415451
5	Type I diabetes mellitus_Homo sapiens_hsa04940	4.45771480
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.89146231
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	3.26036781
8	Viral myocarditis_Homo sapiens_hsa05416	2.99954863
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.97803761
10	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.90230351
11	Leishmaniasis_Homo sapiens_hsa05140	2.44593069
12	Rheumatoid arthritis_Homo sapiens_hsa05323	2.41381803
13	Ribosome_Homo sapiens_hsa03010	2.34595810
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.33063136
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.76550939
16	Regulation of autophagy_Homo sapiens_hsa04140	1.50932118
17	Toxoplasmosis_Homo sapiens_hsa05145	1.35561373
18	Basal transcription factors_Homo sapiens_hsa03022	1.34841481
19	RNA polymerase_Homo sapiens_hsa03020	1.23754391
20	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.15374347
21	Tuberculosis_Homo sapiens_hsa05152	1.12141935
22	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.10469889
23	African trypanosomiasis_Homo sapiens_hsa05143	1.08525377
24	Phagosome_Homo sapiens_hsa04145	1.06912256
25	Proteasome_Homo sapiens_hsa03050	1.01668563
26	Oxidative phosphorylation_Homo sapiens_hsa00190	0.98108808
27	Herpes simplex infection_Homo sapiens_hsa05168	0.97901523
28	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.96792057
29	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.96460729
30	Olfactory transduction_Homo sapiens_hsa04740	0.90661455
31	Protein export_Homo sapiens_hsa03060	0.88214701
32	Influenza A_Homo sapiens_hsa05164	0.84906418
33	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.78527142
34	Parkinsons disease_Homo sapiens_hsa05012	0.77930720
35	ABC transporters_Homo sapiens_hsa02010	0.74904148
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.69564951
37	Histidine metabolism_Homo sapiens_hsa00340	0.69239962
38	Huntingtons disease_Homo sapiens_hsa05016	0.68033724
39	Primary immunodeficiency_Homo sapiens_hsa05340	0.67276037
40	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65686664
41	Nicotine addiction_Homo sapiens_hsa05033	0.60761711
42	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.60368454
43	Morphine addiction_Homo sapiens_hsa05032	0.55589050
44	Phototransduction_Homo sapiens_hsa04744	0.55149687
45	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.52729449
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.52235916
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.48817112
48	HTLV-I infection_Homo sapiens_hsa05166	0.47971792
49	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.46921498
50	GABAergic synapse_Homo sapiens_hsa04727	0.46094614
51	Alzheimers disease_Homo sapiens_hsa05010	0.43434772
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41797498
53	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.41220317
54	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.37946568
55	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36948033
56	Malaria_Homo sapiens_hsa05144	0.35877730
57	Caffeine metabolism_Homo sapiens_hsa00232	0.35311702
58	Cell cycle_Homo sapiens_hsa04110	0.33947278
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.33939494
60	Taste transduction_Homo sapiens_hsa04742	0.31702855
61	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30135799
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.30122896
63	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28545006
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.28101886
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.26527385
66	Collecting duct acid secretion_Homo sapiens_hsa04966	0.25744090
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.25142849
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.24191978
69	RNA degradation_Homo sapiens_hsa03018	0.22630479
70	Legionellosis_Homo sapiens_hsa05134	0.21431074
71	Retinol metabolism_Homo sapiens_hsa00830	0.19340004
72	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.17907064
73	Protein digestion and absorption_Homo sapiens_hsa04974	0.17545519
74	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.17310495
75	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.16665792
76	Salivary secretion_Homo sapiens_hsa04970	0.15612834
77	Mineral absorption_Homo sapiens_hsa04978	0.15390538
78	Shigellosis_Homo sapiens_hsa05131	0.12602097
79	Purine metabolism_Homo sapiens_hsa00230	0.12237734
80	Oocyte meiosis_Homo sapiens_hsa04114	0.11853971
81	Complement and coagulation cascades_Homo sapiens_hsa04610	0.10252533
82	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.10221054
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.09473871
84	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.08604756
85	Chemokine signaling pathway_Homo sapiens_hsa04062	0.07927291
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.06177486
87	RNA transport_Homo sapiens_hsa03013	0.05877332
88	Spliceosome_Homo sapiens_hsa03040	0.05707097
89	Tryptophan metabolism_Homo sapiens_hsa00380	0.05523184
90	Amphetamine addiction_Homo sapiens_hsa05031	0.04900518
91	Circadian entrainment_Homo sapiens_hsa04713	0.04147779
92	Sulfur metabolism_Homo sapiens_hsa00920	0.03377395
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	-0.0300254
94	Salmonella infection_Homo sapiens_hsa05132	-0.0290182
95	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	-0.0242280
96	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	-0.0188672
97	Alcoholism_Homo sapiens_hsa05034	-0.0095283
98	Glycerolipid metabolism_Homo sapiens_hsa00561	-0.0082125
99	Linoleic acid metabolism_Homo sapiens_hsa00591	-0.0076396
100	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	-0.0019751

RFPL4AL1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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