RFPL4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)8.56639463
2mitotic metaphase plate congression (GO:0007080)8.32093595
3gonadal mesoderm development (GO:0007506)7.76117139
4regulation of meiosis I (GO:0060631)6.75912518
5negative regulation of hormone metabolic process (GO:0032351)6.60076521
6negative regulation of hormone biosynthetic process (GO:0032353)6.60076521
7regulation of retinoic acid receptor signaling pathway (GO:0048385)6.58949489
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)6.57865981
9positive regulation of meiotic cell cycle (GO:0051446)6.37749322
10oocyte development (GO:0048599)6.34486399
11metaphase plate congression (GO:0051310)6.33262646
12regulation of exit from mitosis (GO:0007096)6.10302144
13regulation of establishment of cell polarity (GO:2000114)5.82452642
14positive regulation of meiosis (GO:0045836)5.81087353
15DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla5.79836307
16monoubiquitinated protein deubiquitination (GO:0035520)5.73356802
17regulation of RIG-I signaling pathway (GO:0039535)5.60709671
18DNA damage response, signal transduction resulting in transcription (GO:0042772)5.56362906
19regulation of transcription from RNA polymerase I promoter (GO:0006356)5.52724157
20meiosis I (GO:0007127)5.51568520
21regulation of glucocorticoid metabolic process (GO:0031943)5.38375389
22regulation of spindle organization (GO:0090224)5.35360498
23N-terminal protein amino acid acetylation (GO:0006474)5.34071671
24chromosome organization involved in meiosis (GO:0070192)5.30190950
25protein localization to kinetochore (GO:0034501)5.22648435
26male meiosis I (GO:0007141)5.19908740
27maturation of 5.8S rRNA (GO:0000460)5.08816284
28establishment of chromosome localization (GO:0051303)5.06553721
29protein localization to chromosome, centromeric region (GO:0071459)4.95658050
30regulation of establishment or maintenance of cell polarity (GO:0032878)4.91932608
31meiotic chromosome segregation (GO:0045132)4.88759979
32multicellular organism reproduction (GO:0032504)4.87285786
33regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.85044878
34oocyte maturation (GO:0001556)4.81883970
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.79387600
36resolution of meiotic recombination intermediates (GO:0000712)4.69256360
37regulation of alternative mRNA splicing, via spliceosome (GO:0000381)4.56924960
38microtubule depolymerization (GO:0007019)4.49388995
39positive regulation of catecholamine secretion (GO:0033605)4.48151343
40mitotic chromosome condensation (GO:0007076)4.44893727
41DNA replication checkpoint (GO:0000076)4.42289639
42negative regulation of Ras GTPase activity (GO:0034261)4.41211675
43synaptonemal complex assembly (GO:0007130)4.35254536
44regulation of sister chromatid cohesion (GO:0007063)4.34007734
45regulation of mitotic spindle organization (GO:0060236)4.33271568
46negative regulation of keratinocyte proliferation (GO:0010839)4.31706080
47female gonad development (GO:0008585)4.27539337
48acrosome reaction (GO:0007340)4.20425517
49positive regulation of chromosome segregation (GO:0051984)4.19825516
50regulation of meiosis (GO:0040020)4.19106740
51protein localization to chromosome (GO:0034502)4.18879806
52binding of sperm to zona pellucida (GO:0007339)4.16931410
53negative regulation of alcohol biosynthetic process (GO:1902931)4.11793908
54mitotic sister chromatid segregation (GO:0000070)4.09004096
55transcription from mitochondrial promoter (GO:0006390)4.08757272
56DNA methylation involved in gamete generation (GO:0043046)4.06512228
57sister chromatid cohesion (GO:0007062)4.06226864
58protein K48-linked deubiquitination (GO:0071108)4.04161931
59regulation of RNA export from nucleus (GO:0046831)4.03683747
60histone H2A monoubiquitination (GO:0035518)4.02643601
61centriole replication (GO:0007099)4.02466702
62snRNA transcription (GO:0009301)4.02366675
63poly(A)+ mRNA export from nucleus (GO:0016973)4.00906790
64regulation of acrosome reaction (GO:0060046)3.99357728
65synaptonemal complex organization (GO:0070193)3.93909514
66inner cell mass cell proliferation (GO:0001833)3.91260326
67positive regulation of megakaryocyte differentiation (GO:0045654)3.87330709
68purine nucleobase biosynthetic process (GO:0009113)3.86151472
69histone exchange (GO:0043486)3.85202429
70myoblast migration (GO:0051451)3.85068755
71negative regulation of meiosis (GO:0045835)3.83424046
72positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.83314389
73positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.83314389
74positive regulation of mitotic sister chromatid separation (GO:1901970)3.83314389
75single fertilization (GO:0007338)3.79800039
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.78577573
77male meiosis (GO:0007140)3.76483396
78synapsis (GO:0007129)3.71842285
79lens morphogenesis in camera-type eye (GO:0002089)3.71545646
80regulation of DNA endoreduplication (GO:0032875)3.69895056
81meiotic nuclear division (GO:0007126)3.67909761
82regulation of chromosome segregation (GO:0051983)3.67726741
83mitotic sister chromatid cohesion (GO:0007064)3.65828907
84regulation of histone H3-K27 methylation (GO:0061085)3.65451396
85mitochondrial RNA metabolic process (GO:0000959)3.64644776
86chromosome segregation (GO:0007059)3.63156872
87meiotic cell cycle process (GO:1903046)3.62594370
88positive regulation of histone H3-K4 methylation (GO:0051571)3.61417363
89regulation of telomere maintenance via telomerase (GO:0032210)3.60417293
90nuclear pore complex assembly (GO:0051292)3.60226488
91negative regulation of DNA-dependent DNA replication (GO:2000104)3.56505033
92protein K6-linked ubiquitination (GO:0085020)3.55189996
93regulation of female receptivity (GO:0045924)3.53147304
94histone demethylation (GO:0016577)3.51512786
95sphingosine metabolic process (GO:0006670)3.50433980
96regulation of helicase activity (GO:0051095)3.49851688
97RNA localization (GO:0006403)3.49687963
98regulation of steroid hormone biosynthetic process (GO:0090030)3.49617352
99histone H3-K9 demethylation (GO:0033169)3.49225692
100maturation of SSU-rRNA (GO:0030490)3.48946939
101female gamete generation (GO:0007292)3.46165958
102regulation of centriole replication (GO:0046599)3.46002497
103histone lysine demethylation (GO:0070076)3.45909170
104DNA damage induced protein phosphorylation (GO:0006975)3.39953164
105positive regulation of uterine smooth muscle contraction (GO:0070474)3.39652666
106CENP-A containing nucleosome assembly (GO:0034080)3.39487291
107regulation of meiotic cell cycle (GO:0051445)3.37843485
108regulation of histone H3-K9 methylation (GO:0051570)3.32944667
109microtubule polymerization or depolymerization (GO:0031109)3.32172189
110regulation of mRNA splicing, via spliceosome (GO:0048024)3.31772792
111meiotic cell cycle (GO:0051321)3.31114647
112reproduction (GO:0000003)3.30355804
113spindle checkpoint (GO:0031577)3.29584339
114regulation of nucleobase-containing compound transport (GO:0032239)3.28489718
115response to UV-C (GO:0010225)3.27770305
116sister chromatid segregation (GO:0000819)3.26669429
117protein demethylation (GO:0006482)3.26143515
118protein dealkylation (GO:0008214)3.26143515
119DNA replication-independent nucleosome organization (GO:0034724)3.25573975
120DNA replication-independent nucleosome assembly (GO:0006336)3.25573975
121negative regulation of telomere maintenance (GO:0032205)3.23548936
122DNA synthesis involved in DNA repair (GO:0000731)3.22313458
123chromatin remodeling at centromere (GO:0031055)3.21950716
124protein K63-linked deubiquitination (GO:0070536)3.21666621
125histone H2A ubiquitination (GO:0033522)3.20847498
126regulation of cytokine production involved in inflammatory response (GO:1900015)3.20777494
127vitamin transmembrane transport (GO:0035461)3.19093134
128fertilization (GO:0009566)3.16914139
129diol metabolic process (GO:0034311)3.16615904
130piRNA metabolic process (GO:0034587)3.16162416
131positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.14671588
132sperm-egg recognition (GO:0035036)3.13001922
133regulation of double-strand break repair via homologous recombination (GO:0010569)3.11958234
134N-terminal protein amino acid modification (GO:0031365)3.11674763
135mitotic nuclear envelope disassembly (GO:0007077)3.11183560
136centriole assembly (GO:0098534)3.10830823
137demethylation (GO:0070988)3.10441917
138glucose catabolic process (GO:0006007)3.10232084
139regulation of keratinocyte proliferation (GO:0010837)3.09391519
140female mating behavior (GO:0060180)3.06657929
141modulation by virus of host process (GO:0019054)3.04044970
142negative regulation of steroid biosynthetic process (GO:0010894)3.01754337
143regulation of mRNA processing (GO:0050684)3.00737078
144telomere maintenance via telomerase (GO:0007004)2.96924989
145negative regulation of smooth muscle cell differentiation (GO:0051151)2.94551577
146negative regulation of mRNA processing (GO:0050686)2.91160117
147intestinal epithelial cell development (GO:0060576)2.90525129
148DNA replication-dependent nucleosome assembly (GO:0006335)2.90104027
149DNA replication-dependent nucleosome organization (GO:0034723)2.90104027
150reciprocal meiotic recombination (GO:0007131)2.88754597
151reciprocal DNA recombination (GO:0035825)2.88754597
152ribosome biogenesis (GO:0042254)2.85614186
153phosphorelay signal transduction system (GO:0000160)2.85271660
154phosphate ion homeostasis (GO:0055062)2.81408521
155trivalent inorganic anion homeostasis (GO:0072506)2.81408521
156positive regulation of DNA-dependent DNA replication (GO:2000105)2.78316545
157negative regulation of histone modification (GO:0031057)2.76351645
158mitotic G2/M transition checkpoint (GO:0044818)2.72171007
159centrosome duplication (GO:0051298)2.71749846
160regulation of histone H3-K4 methylation (GO:0051569)2.70714675
161regulation of mRNA metabolic process (GO:1903311)2.70388818
162attachment of spindle microtubules to kinetochore (GO:0008608)2.67677748
163negative regulation of mRNA metabolic process (GO:1903312)2.63251871
164regulation of defense response to virus by host (GO:0050691)2.62412971
165pancreas development (GO:0031016)2.62334367
166muscle atrophy (GO:0014889)2.62008367
167spermatid development (GO:0007286)2.61263368

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.51853935
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.01451903
3FOXM1_23109430_ChIP-Seq_U2OS_Human6.31840791
4E2F7_22180533_ChIP-Seq_HELA_Human5.47955688
5KAP1_22055183_ChIP-Seq_ESCs_Mouse5.42687767
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.83900799
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.67400388
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.48931349
9SMAD_19615063_ChIP-ChIP_OVARY_Human3.47346786
10VDR_22108803_ChIP-Seq_LS180_Human3.40800029
11AR_21909140_ChIP-Seq_LNCAP_Human3.06739588
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.06238658
13EZH2_22144423_ChIP-Seq_EOC_Human2.82957250
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65333417
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.63613689
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.62843533
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.57749834
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56361615
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.40944130
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.38535879
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26507499
22KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20122426
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.18947113
24TTF2_22483619_ChIP-Seq_HELA_Human2.18151720
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13686906
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.13565005
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.12861245
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12053616
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10646483
30IRF1_19129219_ChIP-ChIP_H3396_Human2.09595733
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07613359
32NOTCH1_21737748_ChIP-Seq_TLL_Human2.02742923
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.88348312
34LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87505612
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85184787
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.81354523
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81004256
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77847004
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.72936307
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72742551
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.69566085
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66356674
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65099518
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.63673795
45CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62274113
46RUNX1_26923725_Chip-Seq_HPCs_Mouse1.59712061
47HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.56608590
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56442140
49FOXP3_21729870_ChIP-Seq_TREG_Human1.55047995
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52902776
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.47393694
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.45912083
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.44300169
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43391680
55POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43391680
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43349420
57* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43154947
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40577460
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37777405
60ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37402839
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34934980
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34395256
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33970077
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33436843
65CBP_21632823_ChIP-Seq_H3396_Human1.32019839
66RNF2_27304074_Chip-Seq_NSC_Mouse1.31560103
67DCP1A_22483619_ChIP-Seq_HELA_Human1.31251427
68VDR_23849224_ChIP-Seq_CD4+_Human1.30431162
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30021911
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27409005
71KAP1_27257070_Chip-Seq_ESCs_Mouse1.26468680
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23961714
73FUS_26573619_Chip-Seq_HEK293_Human1.22146219
74IGF1R_20145208_ChIP-Seq_DFB_Human1.21494599
75MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21063878
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20301702
77MYC_18940864_ChIP-ChIP_HL60_Human1.20095529
78ELK1_19687146_ChIP-ChIP_HELA_Human1.18151460
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17862059
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16431527
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15545644
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13720487
83NCOR_22424771_ChIP-Seq_293T_Human1.13330989
84XRN2_22483619_ChIP-Seq_HELA_Human1.13219941
85* TCF4_23295773_ChIP-Seq_U87_Human1.11743477
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11278220
87GATA3_26560356_Chip-Seq_TH1_Human1.11217655
88AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08745071
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.07307632
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06822869
91FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.06764987
92STAT1_17558387_ChIP-Seq_HELA_Human1.06413394
93GABP_19822575_ChIP-Seq_HepG2_Human1.06267640
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04083463
95PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.03924407
96STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03870252
97NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03107046
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03034860
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01213983
100GBX2_23144817_ChIP-Seq_PC3_Human1.01213146
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.01028251
102TBL1_22424771_ChIP-Seq_293T_Human1.00410121
103YY1_21170310_ChIP-Seq_MESCs_Mouse1.00147181
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.99778719
105STAT3_18555785_ChIP-Seq_MESCs_Mouse0.96977828
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96732835
107RXR_22108803_ChIP-Seq_LS180_Human0.96490421
108NCOR1_26117541_ChIP-Seq_K562_Human0.94759133
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93380279
110STAT3_23295773_ChIP-Seq_U87_Human0.93370660
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93194191
112SOX2_18555785_Chip-Seq_ESCs_Mouse0.93130814
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93032618
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93032618
115KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93032618
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91645810
117ESR1_20079471_ChIP-ChIP_T-47D_Human0.90889651
118* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90387430
119ERG_20517297_ChIP-Seq_VCAP_Human0.90058703
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89815119
121CDX2_22108803_ChIP-Seq_LS180_Human0.89636777
122FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89410007
123NMYC_18555785_Chip-Seq_ESCs_Mouse0.88718804
124TP53_22573176_ChIP-Seq_HFKS_Human0.88506322
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86979257
126ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86568598
127NFYA_21822215_ChIP-Seq_K562_Human0.86288251
128STAT3_18555785_Chip-Seq_ESCs_Mouse0.84865760
129SMAD4_21799915_ChIP-Seq_A2780_Human0.84793369
130NELFA_20434984_ChIP-Seq_ESCs_Mouse0.83820250
131ZNF274_21170338_ChIP-Seq_K562_Hela0.83448967
132KDM5A_27292631_Chip-Seq_BREAST_Human0.83312629
133RAC3_21632823_ChIP-Seq_H3396_Human0.82984062
134PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82920422
135EZH2_27294783_Chip-Seq_NPCs_Mouse0.82208043
136FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81502229
137* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81025825
138KLF4_18555785_Chip-Seq_ESCs_Mouse0.80719629
139MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.80499516
140GATA3_21867929_ChIP-Seq_TH1_Mouse0.79522530
141KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78977751
142* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78839002
143CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.77968880
144TCF4_22108803_ChIP-Seq_LS180_Human0.77811143
145POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77525220
146VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77513659
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.76660082
148FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.76234157
149PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.76196719
150TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76183430
151GABP_17652178_ChIP-ChIP_JURKAT_Human0.76107300
152MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75804720
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75055312
154SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.73881680
155KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.73794510
156ZFX_18555785_Chip-Seq_ESCs_Mouse0.73714960
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.73272905
158EOMES_21245162_ChIP-Seq_HESCs_Human0.72896023
159CBX2_27304074_Chip-Seq_ESCs_Mouse0.72425273
160DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.72229222
161TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.71727673
162HNFA_21074721_ChIP-Seq_CACO-2_Human0.71629689
163GF1_26923725_Chip-Seq_HPCs_Mouse0.71053833
164CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70782020
165TAL1_26923725_Chip-Seq_HPCs_Mouse0.68421488
166ETV1_20927104_ChIP-Seq_GIST48_Human0.68277617
167CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68242955

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.95557151
2MP0003693_abnormal_embryo_hatching4.67196800
3MP0002102_abnormal_ear_morphology4.61121973
4MP0000678_abnormal_parathyroid_gland3.96683659
5MP0006292_abnormal_olfactory_placode3.93559549
6MP0009379_abnormal_foot_pigmentation3.80987881
7MP0008057_abnormal_DNA_replication3.78345191
8MP0003283_abnormal_digestive_organ3.53338966
9MP0008007_abnormal_cellular_replicative3.51018510
10MP0003718_maternal_effect3.40622456
11MP0008877_abnormal_DNA_methylation3.34711456
12MP0003111_abnormal_nucleus_morphology3.33606477
13MP0003077_abnormal_cell_cycle3.24980867
14MP0003123_paternal_imprinting2.94985516
15MP0005408_hypopigmentation2.84312345
16MP0005410_abnormal_fertilization2.66098206
17MP0000427_abnormal_hair_cycle2.65451700
18MP0010094_abnormal_chromosome_stability2.61811138
19MP0004957_abnormal_blastocyst_morpholog2.49545027
20MP0009840_abnormal_foam_cell2.43961796
21MP0010307_abnormal_tumor_latency2.39701133
22MP0003646_muscle_fatigue2.34696792
23MP0003136_yellow_coat_color2.17761493
24MP0002653_abnormal_ependyma_morphology2.15060284
25MP0004185_abnormal_adipocyte_glucose2.08450915
26MP0008058_abnormal_DNA_repair2.04366867
27MP0005220_abnormal_exocrine_pancreas2.03591107
28MP0003937_abnormal_limbs/digits/tail_de1.99539999
29MP0001730_embryonic_growth_arrest1.95840648
30MP0006276_abnormal_autonomic_nervous1.94793096
31MP0001119_abnormal_female_reproductive1.90355793
32MP0000566_synostosis1.87752892
33MP0001502_abnormal_circadian_rhythm1.86967173
34MP0002210_abnormal_sex_determination1.84240951
35MP0001929_abnormal_gametogenesis1.83809961
36MP0002249_abnormal_larynx_morphology1.81148287
37MP0000462_abnormal_digestive_system1.78753803
38MP0004233_abnormal_muscle_weight1.77118422
39MP0000653_abnormal_sex_gland1.75449109
40MP0003699_abnormal_female_reproductive1.73415332
41MP0003787_abnormal_imprinting1.69537444
42MP0000579_abnormal_nail_morphology1.68458803
43MP0000350_abnormal_cell_proliferation1.68441726
44MP0005360_urolithiasis1.66089566
45MP0003119_abnormal_digestive_system1.63316113
46MP0003890_abnormal_embryonic-extraembry1.63303787
47MP0005647_abnormal_sex_gland1.58956515
48MP0001529_abnormal_vocalization1.58498428
49MP0005389_reproductive_system_phenotype1.56072250
50MP0005395_other_phenotype1.55294178
51MP0001145_abnormal_male_reproductive1.50385431
52MP0003315_abnormal_perineum_morphology1.49742070
53MP0002877_abnormal_melanocyte_morpholog1.49436341
54MP0001666_abnormal_nutrient_absorption1.48550638
55MP0002085_abnormal_embryonic_tissue1.46241756
56MP0008995_early_reproductive_senescence1.45888828
57MP0005380_embryogenesis_phenotype1.42947178
58MP0001672_abnormal_embryogenesis/_devel1.42947178
59MP0002084_abnormal_developmental_patter1.35661507
60MP0000647_abnormal_sebaceous_gland1.35485335
61MP0008932_abnormal_embryonic_tissue1.34309458
62MP0005076_abnormal_cell_differentiation1.33351689
63MP0001664_abnormal_digestion1.33044523
64MP0002396_abnormal_hematopoietic_system1.32423337
65MP0009697_abnormal_copulation1.30365894
66MP0003938_abnormal_ear_development1.29635016
67MP0001697_abnormal_embryo_size1.28152093
68MP0002751_abnormal_autonomic_nervous1.26396794
69MP0000372_irregular_coat_pigmentation1.26105938
70MP0003121_genomic_imprinting1.22903133
71MP0004043_abnormal_pH_regulation1.17182317
72MP0003984_embryonic_growth_retardation1.14089631
73MP0000639_abnormal_adrenal_gland1.14018508
74MP0001851_eye_inflammation1.13256233
75MP0002277_abnormal_respiratory_mucosa1.12357354
76MP0005187_abnormal_penis_morphology1.11272466
77MP0003755_abnormal_palate_morphology1.11109321
78MP0009333_abnormal_splenocyte_physiolog1.10342644
79MP0002088_abnormal_embryonic_growth/wei1.07047103
80MP0000049_abnormal_middle_ear1.06895516
81MP0003221_abnormal_cardiomyocyte_apopto1.04899450
82MP0002161_abnormal_fertility/fecundity1.04242141
83MP0003698_abnormal_male_reproductive1.02415201
84MP0003959_abnormal_lean_body1.01664739
85MP0002086_abnormal_extraembryonic_tissu1.01380565
86MP0005310_abnormal_salivary_gland1.00928430
87MP0001986_abnormal_taste_sensitivity0.97152173
88MP0002233_abnormal_nose_morphology0.96529821
89MP0006036_abnormal_mitochondrial_physio0.95278908
90MP0005248_abnormal_Harderian_gland0.93722493
91MP0003183_abnormal_peptide_metabolism0.92182851
92MP0001764_abnormal_homeostasis0.91548955
93MP0003866_abnormal_defecation0.90850821
94MP0006072_abnormal_retinal_apoptosis0.86041955
95MP0003935_abnormal_craniofacial_develop0.85886782
96MP0002080_prenatal_lethality0.85800793
97MP0003950_abnormal_plasma_membrane0.85582778
98MP0003186_abnormal_redox_activity0.84945319
99MP0000432_abnormal_head_morphology0.84533928
100MP0009672_abnormal_birth_weight0.83990631
101MP0000627_abnormal_mammary_gland0.83487525
102MP0000631_abnormal_neuroendocrine_gland0.81765778
103MP0005621_abnormal_cell_physiology0.81442034
104MP0005646_abnormal_pituitary_gland0.81210224
105MP0009703_decreased_birth_body0.80964723
106MP0001286_abnormal_eye_development0.80814115
107MP0009250_abnormal_appendicular_skeleto0.78570159
108MP0001849_ear_inflammation0.78365441
109MP0004264_abnormal_extraembryonic_tissu0.71776884
110MP0000470_abnormal_stomach_morphology0.71584775
111MP0004270_analgesia0.68841350
112MP0003861_abnormal_nervous_system0.68117911
113MP0005197_abnormal_uvea_morphology0.68063750
114MP0002638_abnormal_pupillary_reflex0.67847179
115MP0003656_abnormal_erythrocyte_physiolo0.67415391
116MP0003936_abnormal_reproductive_system0.66193808
117MP0002160_abnormal_reproductive_system0.64290426
118MP0005423_abnormal_somatic_nervous0.63399289
119MP0009765_abnormal_xenobiotic_induced0.62518403
120MP0002184_abnormal_innervation0.62421276
121MP0002229_neurodegeneration0.62272832
122MP0005508_abnormal_skeleton_morphology0.61606720
123MP0002095_abnormal_skin_pigmentation0.61398864
124MP0002163_abnormal_gland_morphology0.61190576
125MP0001440_abnormal_grooming_behavior0.59812043
126MP0003806_abnormal_nucleotide_metabolis0.59185150
127MP0003786_premature_aging0.58978212
128MP0002019_abnormal_tumor_incidence0.58930010
129MP0005334_abnormal_fat_pad0.58884585
130MP0002090_abnormal_vision0.58564092
131MP0002269_muscular_atrophy0.57815413
132MP0010234_abnormal_vibrissa_follicle0.57319902
133MP0000428_abnormal_craniofacial_morphol0.56983241
134MP0005666_abnormal_adipose_tissue0.56197396
135MP0002127_abnormal_cardiovascular_syste0.55784832
136MP0005645_abnormal_hypothalamus_physiol0.55661339
137MP0002177_abnormal_outer_ear0.55332633
138MP0002796_impaired_skin_barrier0.54384506
139MP0010030_abnormal_orbit_morphology0.53245723
140MP0004145_abnormal_muscle_electrophysio0.53145603
141MP0002938_white_spotting0.52139029
142MP0001299_abnormal_eye_distance/0.51447003
143MP0001346_abnormal_lacrimal_gland0.50455312
144MP0001881_abnormal_mammary_gland0.49513445
145MP0005384_cellular_phenotype0.45726334
146MP0000313_abnormal_cell_death0.45110200
147MP0001216_abnormal_epidermal_layer0.44600843
148MP0004197_abnormal_fetal_growth/weight/0.44063977
149MP0003868_abnormal_feces_composition0.43219908

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)7.37224046
2Facial hemangioma (HP:0000329)6.24328981
3Prostate neoplasm (HP:0100787)5.77036417
4Chromosomal breakage induced by crosslinking agents (HP:0003221)5.41176973
5Birth length less than 3rd percentile (HP:0003561)5.28851153
6Chromsome breakage (HP:0040012)5.03375687
7Capillary hemangiomas (HP:0005306)5.03355462
8Papillary thyroid carcinoma (HP:0002895)4.95209188
9Abnormality of the labia minora (HP:0012880)4.84814369
10Median cleft lip (HP:0000161)4.61006663
11Breast hypoplasia (HP:0003187)4.55776481
12Azoospermia (HP:0000027)4.35248538
13Patellar aplasia (HP:0006443)4.28094636
14Shawl scrotum (HP:0000049)4.09256223
15Aplasia/Hypoplasia of the patella (HP:0006498)3.98627776
16Tetany (HP:0001281)3.85798708
17Short tibia (HP:0005736)3.84859495
18Male infertility (HP:0003251)3.81083494
19Abnormal number of incisors (HP:0011064)3.73407429
20Spontaneous abortion (HP:0005268)3.72259293
21Breast aplasia (HP:0100783)3.71625654
22Aplasia/Hypoplasia of the tibia (HP:0005772)3.68046897
23Acute myeloid leukemia (HP:0004808)3.64751369
24Abnormal spermatogenesis (HP:0008669)3.63081381
25Meckel diverticulum (HP:0002245)3.60876297
26Atonic seizures (HP:0010819)3.58390874
27Aplasia/Hypoplasia of the breasts (HP:0010311)3.49540395
28Amelogenesis imperfecta (HP:0000705)3.47480290
29Abnormality of the preputium (HP:0100587)3.47086724
30Carpal bone hypoplasia (HP:0001498)3.41952957
31Sensorimotor neuropathy (HP:0007141)3.40351735
32Abnormal auditory evoked potentials (HP:0006958)3.36804113
33Abnormality of the ileum (HP:0001549)3.32703067
34Abnormal gallbladder physiology (HP:0012438)3.29461268
35Cholecystitis (HP:0001082)3.29461268
36Aplasia/Hypoplasia of the uvula (HP:0010293)3.22694725
37Facial cleft (HP:0002006)3.22602847
38Microglossia (HP:0000171)3.22271830
39Adrenal hypoplasia (HP:0000835)3.21927669
40Abnormality of chromosome stability (HP:0003220)3.18475806
41Abnormality of the nasal septum (HP:0000419)3.14392701
42Abnormality of the prostate (HP:0008775)3.06155381
43Flat capital femoral epiphysis (HP:0003370)3.02400405
44Submucous cleft hard palate (HP:0000176)2.98921933
45Thyroid carcinoma (HP:0002890)2.96436092
46Abnormality of dental color (HP:0011073)2.95642207
47Hyperphosphatemia (HP:0002905)2.93910735
48Oligodactyly (hands) (HP:0001180)2.87852786
49Abnormality of lateral ventricle (HP:0030047)2.85893432
50Oligodactyly (HP:0012165)2.84387651
51Acute lymphatic leukemia (HP:0006721)2.84021017
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81734124
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.81734124
54Metaphyseal dysplasia (HP:0100255)2.80331942
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.77478739
56Reticulocytopenia (HP:0001896)2.74416350
57Gout (HP:0001997)2.74214446
58Atrioventricular block (HP:0001678)2.68483061
59Aplasia/Hypoplasia of the earlobes (HP:0009906)2.66676739
60Tetraparesis (HP:0002273)2.66591350
61Hypoparathyroidism (HP:0000829)2.59527409
62Mutism (HP:0002300)2.57564750
63Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.56967985
64Abnormality of the fingertips (HP:0001211)2.54191500
65Cystic hygroma (HP:0000476)2.53946333
66Short chin (HP:0000331)2.51628114
67Increased hepatocellular lipid droplets (HP:0006565)2.50802879
68Oral leukoplakia (HP:0002745)2.45976687
69Multiple enchondromatosis (HP:0005701)2.45592955
70Absent radius (HP:0003974)2.43924365
71Short middle phalanx of the 5th finger (HP:0004220)2.43003655
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.42203455
73Wrist flexion contracture (HP:0001239)2.39966165
74Abdominal situs inversus (HP:0003363)2.38791032
75Abnormality of abdominal situs (HP:0011620)2.38791032
76Pancreatic fibrosis (HP:0100732)2.38641068
77Enlarged penis (HP:0000040)2.37897652
78Anhidrosis (HP:0000970)2.37762397
79Decreased subcutaneous fat (HP:0001002)2.36955995
80Abnormal pancreas size (HP:0012094)2.35282399
81Abnormality of male internal genitalia (HP:0000022)2.35203017
82Short thumb (HP:0009778)2.34996717
83Myelodysplasia (HP:0002863)2.34352059
84Supernumerary spleens (HP:0009799)2.34035108
85Clubbing of toes (HP:0100760)2.32490432
86Complete atrioventricular canal defect (HP:0001674)2.31205848
87Lip pit (HP:0100267)2.30789564
88Aplasia involving forearm bones (HP:0009822)2.30242858
89Absent forearm bone (HP:0003953)2.30242858
90Abnormality of the corticospinal tract (HP:0002492)2.30194482
91Partial agenesis of the corpus callosum (HP:0001338)2.29647397
92Abnormality of chromosome segregation (HP:0002916)2.24706410
93Upper limb muscle weakness (HP:0003484)2.23005863
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22812835
95Abnormality of alanine metabolism (HP:0010916)2.22812835
96Hyperalaninemia (HP:0003348)2.22812835
97Aplasia/Hypoplasia involving the musculature (HP:0001460)2.22349543
98Small intestinal stenosis (HP:0012848)2.20957757
99Duodenal stenosis (HP:0100867)2.20957757
100Secondary amenorrhea (HP:0000869)2.20149682
101Congenital sensorineural hearing impairment (HP:0008527)2.18649410
102Increased CSF lactate (HP:0002490)2.18285738
103Glossoptosis (HP:0000162)2.15343851
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.14777065
105Truncus arteriosus (HP:0001660)2.14430823
106Nephroblastoma (Wilms tumor) (HP:0002667)2.13469477
107Ectopic kidney (HP:0000086)2.13386192
108Rib fusion (HP:0000902)2.12804809
109Exertional dyspnea (HP:0002875)2.11655544
110Renal Fanconi syndrome (HP:0001994)2.10321746
111Abnormality of the septum pellucidum (HP:0007375)2.09335370
112Microretrognathia (HP:0000308)2.08674152
113Abnormality of the phalanges of the hallux (HP:0010057)2.06470806
114Ileus (HP:0002595)2.05952403
115Horseshoe kidney (HP:0000085)2.05302172
116Lipid accumulation in hepatocytes (HP:0006561)2.04948767
117Delayed puberty (HP:0000823)2.04472383
118Ankle contracture (HP:0006466)2.04160353
119Osteomalacia (HP:0002749)2.02418473
120Sandal gap (HP:0001852)2.01921383
121Fibular aplasia (HP:0002990)2.00674213
122Pendular nystagmus (HP:0012043)1.96700306
123Sparse lateral eyebrow (HP:0005338)1.96290394
124Abnormality of the carotid arteries (HP:0005344)1.96271156
125Aplasia/Hypoplasia of the sternum (HP:0006714)1.96189448
126Embryonal renal neoplasm (HP:0011794)1.95096162
127Mask-like facies (HP:0000298)1.94544056
128Shoulder girdle muscle weakness (HP:0003547)1.94453452
129Abnormality of cells of the erythroid lineage (HP:0012130)1.94424763
130Arteriovenous malformation (HP:0100026)1.93559539
131Abnormality of the frontal sinuses (HP:0002687)1.92975084
132Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92746812
133Bone marrow hypocellularity (HP:0005528)1.92171090
134Abnormal delivery (HP:0001787)1.90656106
135Acute necrotizing encephalopathy (HP:0006965)1.88785378
136Heart block (HP:0012722)1.88717757
137Cafe-au-lait spot (HP:0000957)1.88549548
138Absent septum pellucidum (HP:0001331)1.88115860
139Autoimmune thrombocytopenia (HP:0001973)1.87101312
140Maternal diabetes (HP:0009800)1.86352854
141Type 2 muscle fiber atrophy (HP:0003554)1.83699486
142Abnormality of calcium-phosphate metabolism (HP:0100530)1.83623567
143Tracheoesophageal fistula (HP:0002575)1.83369694
144Overlapping toe (HP:0001845)1.82915946
145Abnormality of the incisor (HP:0000676)1.81963309
146Absent thumb (HP:0009777)1.81490338
147Impulsivity (HP:0100710)1.81356976
148Myocardial infarction (HP:0001658)1.80469701
149Pulmonary fibrosis (HP:0002206)1.80460946
150Tinnitus (HP:0000360)1.80430211
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.79864036
152CNS hypomyelination (HP:0003429)1.79698410
153Abnormality of subcutaneous fat tissue (HP:0001001)1.79264560
154Type I diabetes mellitus (HP:0100651)1.79203001
155Tetraplegia (HP:0002445)1.79177234
156Irregular epiphyses (HP:0010582)1.78572243
157Abnormal atrioventricular conduction (HP:0005150)1.78366351
158Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.78271944
159Diaphragmatic weakness (HP:0009113)1.77489573
160Abnormality of the anterior horn cell (HP:0006802)1.76800342
161Degeneration of anterior horn cells (HP:0002398)1.76800342
162Spinal muscular atrophy (HP:0007269)1.76462007
163Abnormality of purine metabolism (HP:0004352)1.76373444
164Bicornuate uterus (HP:0000813)1.76179706
165Abnormality of reticulocytes (HP:0004312)1.74389562
166Abnormality of the hepatic vasculature (HP:0006707)1.73129056
167Diastasis recti (HP:0001540)1.72591159
168Mitochondrial inheritance (HP:0001427)1.72519496
169Abnormality of the duodenum (HP:0002246)1.71913075
170Increased serum pyruvate (HP:0003542)1.70521997
171Erectile abnormalities (HP:0100639)1.69492541
172Anal atresia (HP:0002023)1.68474769
173Primary amenorrhea (HP:0000786)1.68447208
174Muscle fiber atrophy (HP:0100295)1.67158678

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.23027891
2LATS25.96818345
3LATS14.58878451
4STK38L4.09429924
5TNIK3.71968822
6MUSK3.71507183
7BRSK23.21208150
8PBK3.09681578
9KSR23.05472296
10ERBB42.78022059
11CDC72.61220143
12SRPK12.59935136
13ZAK2.55589667
14WEE12.45578939
15PLK42.44002515
16PAK62.27194207
17STK32.24997113
18ICK2.23888702
19RAF12.23296310
20MAP3K62.22032891
21NEK22.17518021
22TAOK12.14948208
23CDK191.97825317
24EEF2K1.89953551
25BRSK11.87401524
26TTK1.86366091
27DYRK31.70785568
28STK391.69309195
29PLK11.63860932
30DYRK21.62152512
31TLK11.60405291
32KSR11.58247386
33PLK31.45200325
34CHEK21.41818708
35TEC1.37893391
36NLK1.35260423
37CDK31.34509318
38MAPKAPK31.31897268
39NUAK11.27981446
40ACVR1B1.24139229
41ABL21.23825880
42STK381.21252199
43PKN11.21250377
44AURKB1.18990453
45MST41.16615677
46PDK21.16049384
47CDK121.13926673
48MARK31.10774608
49BRAF1.09005992
50MAP3K91.08474468
51IRAK31.04399967
52WNK11.04020609
53VRK11.01831886
54MKNK21.01130233
55OXSR11.00505917
56MAP2K30.99543933
57FRK0.97548907
58PLK20.96921207
59NME10.96784800
60STK240.96438395
61NTRK30.96024131
62STK100.94924233
63CDK90.94446954
64PRKD30.90874279
65CLK10.89805187
66MELK0.89690047
67GRK70.86947951
68PRKAA20.86556343
69TAOK30.84922437
70CHEK10.84556436
71NEK60.83680135
72EIF2AK10.83649001
73TYRO30.83021379
74WNK40.82118803
75BUB10.79669400
76PRKAA10.76316074
77PIK3CG0.73709636
78TESK20.73630876
79MARK20.72863720
80MAPK130.72819816
81PIM10.72050433
82AURKA0.69830781
83BMPR1B0.66420541
84CSNK1E0.63669404
85CDK70.62855728
86TRPM70.62744711
87EPHA40.59737316
88ATM0.59593638
89BMX0.57886138
90RPS6KA40.56188266
91MAPK100.56074679
92AKT20.54748593
93MAPKAPK50.53712444
94PAK30.52827664
95PIK3CA0.51175700
96CDK20.50744282
97NEK10.48483237
98CSNK2A10.48395689
99ILK0.48092721
100CSNK2A20.47278932
101CDK10.46118119
102TRIM280.44372180
103RPS6KB20.44321203
104TSSK60.44247567
105MTOR0.43359530
106EPHA30.43193354
107RPS6KA50.42630237
108MAPKAPK20.40505833
109PRKD20.39705351
110JAK30.39677381
111EIF2AK20.39343892
112PIM20.38407715
113PRKCI0.36825082
114CDK80.36694528
115DMPK0.35194265
116CAMK40.35021516
117DYRK1A0.34963818
118MAP3K130.34797323
119PRKACB0.34666801
120EIF2AK30.34352808
121MAP3K80.34334311
122PAK10.34185629
123MAP3K30.33776420
124MAP3K20.33266576
125VRK20.32220532
126RET0.31895205
127MAP3K40.31287673
128DDR20.30113149
129BRD40.28890144
130ABL10.28839203
131PDGFRB0.28772660
132AKT30.28604938
133CDK40.27918763
134MKNK10.27601812
135JAK20.26244641
136PRKACA0.24437046
137MAPK10.24339903
138ARAF0.23931701
139MAP2K40.23326498
140CSNK1G10.20392487
141SGK20.19444104
142PINK10.19198873
143MAPK110.18910180
144GSK3B0.18444209
145NTRK20.18416262
146ATR0.17916693
147CAMK1D0.17894384
148CAMK2A0.17692496
149MAPK140.17548632
150CSNK1G20.16684951
151MAP3K50.15596117
152STK40.15201382

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005335.04090327
2RNA polymerase_Homo sapiens_hsa030204.54213663
3Cell cycle_Homo sapiens_hsa041104.39564345
4Ribosome_Homo sapiens_hsa030103.69068064
5Basal transcription factors_Homo sapiens_hsa030223.57955562
6Vitamin B6 metabolism_Homo sapiens_hsa007503.35855833
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.07830814
8Pentose phosphate pathway_Homo sapiens_hsa000303.07457688
9RNA degradation_Homo sapiens_hsa030182.84103769
10Non-homologous end-joining_Homo sapiens_hsa034502.66195305
11Fanconi anemia pathway_Homo sapiens_hsa034602.60019767
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.58894557
13Homologous recombination_Homo sapiens_hsa034402.54727595
14p53 signaling pathway_Homo sapiens_hsa041152.50555980
15RNA transport_Homo sapiens_hsa030132.41881247
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24619036
17Oocyte meiosis_Homo sapiens_hsa041142.21626869
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.00293932
19TGF-beta signaling pathway_Homo sapiens_hsa043501.96624855
20One carbon pool by folate_Homo sapiens_hsa006701.96017025
21mRNA surveillance pathway_Homo sapiens_hsa030151.94461605
22Circadian rhythm_Homo sapiens_hsa047101.88374906
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.86663722
24Ovarian steroidogenesis_Homo sapiens_hsa049131.67467107
25Sulfur metabolism_Homo sapiens_hsa009201.62241099
26Pancreatic cancer_Homo sapiens_hsa052121.55461980
27Linoleic acid metabolism_Homo sapiens_hsa005911.53981129
28Bile secretion_Homo sapiens_hsa049761.53296601
29MicroRNAs in cancer_Homo sapiens_hsa052061.53113769
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48224518
31Fatty acid biosynthesis_Homo sapiens_hsa000611.44726027
32Renal cell carcinoma_Homo sapiens_hsa052111.36090581
33Biosynthesis of amino acids_Homo sapiens_hsa012301.35723786
34Ether lipid metabolism_Homo sapiens_hsa005651.28552545
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.27904981
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27465149
37Pyrimidine metabolism_Homo sapiens_hsa002401.27423474
38Choline metabolism in cancer_Homo sapiens_hsa052311.25022548
39Purine metabolism_Homo sapiens_hsa002301.12406387
40Sphingolipid metabolism_Homo sapiens_hsa006001.12060297
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09116388
42Spliceosome_Homo sapiens_hsa030401.08644476
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.08338851
44Arginine biosynthesis_Homo sapiens_hsa002201.07216616
45Prolactin signaling pathway_Homo sapiens_hsa049171.04681349
46Huntingtons disease_Homo sapiens_hsa050161.02305200
47Retinol metabolism_Homo sapiens_hsa008301.02263005
48GnRH signaling pathway_Homo sapiens_hsa049121.02224342
49Olfactory transduction_Homo sapiens_hsa047400.99939082
50Thyroid cancer_Homo sapiens_hsa052160.94024433
51Nucleotide excision repair_Homo sapiens_hsa034200.93580364
52Small cell lung cancer_Homo sapiens_hsa052220.88906609
53Selenocompound metabolism_Homo sapiens_hsa004500.83640551
54FoxO signaling pathway_Homo sapiens_hsa040680.83519405
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.82864836
56Colorectal cancer_Homo sapiens_hsa052100.82602850
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.81438244
58Systemic lupus erythematosus_Homo sapiens_hsa053220.80916452
59Alcoholism_Homo sapiens_hsa050340.77602930
60Collecting duct acid secretion_Homo sapiens_hsa049660.76321325
61Arginine and proline metabolism_Homo sapiens_hsa003300.75040332
62Tryptophan metabolism_Homo sapiens_hsa003800.74545061
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74258577
64Epstein-Barr virus infection_Homo sapiens_hsa051690.73587242
65Herpes simplex infection_Homo sapiens_hsa051680.71945283
66Protein export_Homo sapiens_hsa030600.71395159
67Adherens junction_Homo sapiens_hsa045200.71339867
68Endometrial cancer_Homo sapiens_hsa052130.70565020
69Dorso-ventral axis formation_Homo sapiens_hsa043200.69265552
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69229348
71Base excision repair_Homo sapiens_hsa034100.69127213
72Phototransduction_Homo sapiens_hsa047440.68521385
73Prostate cancer_Homo sapiens_hsa052150.67259718
74Hepatitis B_Homo sapiens_hsa051610.66552198
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66194972
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65915110
77DNA replication_Homo sapiens_hsa030300.64178773
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63554858
79VEGF signaling pathway_Homo sapiens_hsa043700.60099287
80Mismatch repair_Homo sapiens_hsa034300.59915748
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59672351
82Proteasome_Homo sapiens_hsa030500.59514195
83Parkinsons disease_Homo sapiens_hsa050120.59230121
84Arachidonic acid metabolism_Homo sapiens_hsa005900.59166754
85Steroid biosynthesis_Homo sapiens_hsa001000.58764569
86Folate biosynthesis_Homo sapiens_hsa007900.57268347
87Nitrogen metabolism_Homo sapiens_hsa009100.57120717
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55652717
89Lysine degradation_Homo sapiens_hsa003100.53626896
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52973871
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.52747021
92Hippo signaling pathway_Homo sapiens_hsa043900.51176514
93Vitamin digestion and absorption_Homo sapiens_hsa049770.49449645
94Cocaine addiction_Homo sapiens_hsa050300.49196208
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.47879548
96Estrogen signaling pathway_Homo sapiens_hsa049150.43761339
97Influenza A_Homo sapiens_hsa051640.43234994
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42894309
99Viral carcinogenesis_Homo sapiens_hsa052030.41737082
100Pyruvate metabolism_Homo sapiens_hsa006200.39826588
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38973332
102Long-term depression_Homo sapiens_hsa047300.38766659
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.38079477
104Non-small cell lung cancer_Homo sapiens_hsa052230.38071076
105ErbB signaling pathway_Homo sapiens_hsa040120.36973322
106Inositol phosphate metabolism_Homo sapiens_hsa005620.36028445
107Regulation of autophagy_Homo sapiens_hsa041400.35854343
108Pathways in cancer_Homo sapiens_hsa052000.34818191
109Ras signaling pathway_Homo sapiens_hsa040140.34493924
110Fatty acid metabolism_Homo sapiens_hsa012120.33127720
111Synaptic vesicle cycle_Homo sapiens_hsa047210.31833925
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.31621659
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.31611463
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31114799
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.30839816
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.30716510
117Metabolic pathways_Homo sapiens_hsa011000.30251280
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.30231681
119Insulin secretion_Homo sapiens_hsa049110.30070317
120Oxidative phosphorylation_Homo sapiens_hsa001900.29951895
121Glutathione metabolism_Homo sapiens_hsa004800.29882899
122Chemical carcinogenesis_Homo sapiens_hsa052040.29518256
123MAPK signaling pathway_Homo sapiens_hsa040100.28687431
124Chronic myeloid leukemia_Homo sapiens_hsa052200.28611423
125Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28563182
126Amphetamine addiction_Homo sapiens_hsa050310.27981777
127Bladder cancer_Homo sapiens_hsa052190.27544924
128Serotonergic synapse_Homo sapiens_hsa047260.27071173
129Glucagon signaling pathway_Homo sapiens_hsa049220.26723874
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26597869
131Glioma_Homo sapiens_hsa052140.26137442
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.26096306
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25662916
134Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24675216
135mTOR signaling pathway_Homo sapiens_hsa041500.24365025
136Fatty acid elongation_Homo sapiens_hsa000620.23679443
137Notch signaling pathway_Homo sapiens_hsa043300.22896394
138cAMP signaling pathway_Homo sapiens_hsa040240.22888681
139Melanoma_Homo sapiens_hsa052180.22678554
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.20902188
141AMPK signaling pathway_Homo sapiens_hsa041520.20615302
142HTLV-I infection_Homo sapiens_hsa051660.20579280
143Starch and sucrose metabolism_Homo sapiens_hsa005000.20235287
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.20213076
145Type II diabetes mellitus_Homo sapiens_hsa049300.18591490
146Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18270384
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18101681
148Histidine metabolism_Homo sapiens_hsa003400.17465327
149Tight junction_Homo sapiens_hsa045300.17233827
150Butanoate metabolism_Homo sapiens_hsa006500.16800497
151Apoptosis_Homo sapiens_hsa042100.16485370
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15413187
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.12957445
154Hedgehog signaling pathway_Homo sapiens_hsa043400.12728833
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12197163
156Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.12024818
157Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11306427
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10582293
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10228063

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