RFT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme which catalyzes the translocation of the Man(5)GlcNAc (2)-PP-Dol intermediate from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane in the pathway for the N-glycosylation of proteins. Mutations in this gene are associated with congenital disorder of glycosylation type In. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.62230353
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.62230353
3aromatic amino acid family catabolic process (GO:0009074)4.53929609
4indolalkylamine catabolic process (GO:0046218)4.30909516
5tryptophan catabolic process (GO:0006569)4.30909516
6indole-containing compound catabolic process (GO:0042436)4.30909516
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.25026567
8L-phenylalanine metabolic process (GO:0006558)4.25026567
9tryptophan metabolic process (GO:0006568)4.21266877
10proteasome assembly (GO:0043248)4.11720734
11mitochondrial RNA metabolic process (GO:0000959)4.02639842
12pseudouridine synthesis (GO:0001522)3.99028083
13respiratory chain complex IV assembly (GO:0008535)3.83801832
14maturation of 5.8S rRNA (GO:0000460)3.83303556
15transcription from mitochondrial promoter (GO:0006390)3.81042161
16cullin deneddylation (GO:0010388)3.79238820
17DNA replication checkpoint (GO:0000076)3.74908357
18protein deneddylation (GO:0000338)3.71073141
19DNA strand elongation involved in DNA replication (GO:0006271)3.68305259
20cellular biogenic amine catabolic process (GO:0042402)3.67998467
21amine catabolic process (GO:0009310)3.67998467
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.66051071
23termination of RNA polymerase III transcription (GO:0006386)3.66051071
24nucleobase biosynthetic process (GO:0046112)3.62364452
25regulation of mitochondrial translation (GO:0070129)3.62164409
26peptidyl-glutamic acid carboxylation (GO:0017187)3.59340744
27protein carboxylation (GO:0018214)3.59340744
28DNA strand elongation (GO:0022616)3.57559850
29aldehyde catabolic process (GO:0046185)3.56575886
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53323979
31formation of translation preinitiation complex (GO:0001731)3.50418293
32valine metabolic process (GO:0006573)3.46977059
33telomere maintenance via semi-conservative replication (GO:0032201)3.45568188
34ribosome assembly (GO:0042255)3.45509849
35purine nucleobase biosynthetic process (GO:0009113)3.43829673
36kynurenine metabolic process (GO:0070189)3.42622277
37rRNA modification (GO:0000154)3.38869935
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.38438548
39regulation of mitotic spindle checkpoint (GO:1903504)3.38438548
40spliceosomal snRNP assembly (GO:0000387)3.38357690
41cytochrome complex assembly (GO:0017004)3.37960995
42bile acid biosynthetic process (GO:0006699)3.33508456
43peptidyl-histidine modification (GO:0018202)3.33132752
44signal peptide processing (GO:0006465)3.30929910
45aromatic amino acid family metabolic process (GO:0009072)3.30141424
46NAD biosynthetic process (GO:0009435)3.29219250
47chromatin remodeling at centromere (GO:0031055)3.26639848
48mitochondrial respiratory chain complex assembly (GO:0033108)3.26250968
49deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26166340
50protein localization to kinetochore (GO:0034501)3.25962850
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25469236
52positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.25180377
53nucleotide transmembrane transport (GO:1901679)3.24872571
54NADH dehydrogenase complex assembly (GO:0010257)3.24473588
55mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24473588
56mitochondrial respiratory chain complex I assembly (GO:0032981)3.24473588
57rRNA processing (GO:0006364)3.23127527
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22616922
59negative regulation of ligase activity (GO:0051352)3.22616922
60homocysteine metabolic process (GO:0050667)3.22187563
61CENP-A containing nucleosome assembly (GO:0034080)3.22078160
62indolalkylamine metabolic process (GO:0006586)3.21848127
63ribosomal small subunit assembly (GO:0000028)3.20211507
64superoxide anion generation (GO:0042554)3.19897552
65DNA replication-dependent nucleosome organization (GO:0034723)3.18580644
66DNA replication-dependent nucleosome assembly (GO:0006335)3.18580644
67protein complex biogenesis (GO:0070271)3.18154119
68positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17223744
69tyrosine metabolic process (GO:0006570)3.16781070
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16587983
71IMP biosynthetic process (GO:0006188)3.16047588
72mitotic metaphase plate congression (GO:0007080)3.15925722
73somatic hypermutation of immunoglobulin genes (GO:0016446)3.15020699
74somatic diversification of immune receptors via somatic mutation (GO:0002566)3.15020699
75pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.14232709
76protein K6-linked ubiquitination (GO:0085020)3.13797187
77ribosome biogenesis (GO:0042254)3.12872745
78complement activation, alternative pathway (GO:0006957)3.12386538
79maturation of SSU-rRNA (GO:0030490)3.11107527
80rRNA metabolic process (GO:0016072)3.09616739
81fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09310710
82modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08135840
83positive regulation by organism of defense response of other organism involved in symbiotic interact3.08135840
84modulation by symbiont of host immune response (GO:0052553)3.08135840
85positive regulation by symbiont of host defense response (GO:0052509)3.08135840
86modulation by symbiont of host defense response (GO:0052031)3.08135840
87modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08135840
88detection of molecule of bacterial origin (GO:0032490)3.07710946
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06767213
90response to peptidoglycan (GO:0032494)3.05249885
91nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04686731
92DNA double-strand break processing (GO:0000729)3.03877171
93transcription-coupled nucleotide-excision repair (GO:0006283)3.03036278
94base-excision repair, AP site formation (GO:0006285)3.02226221
95tRNA methylation (GO:0030488)3.02047877
96tRNA processing (GO:0008033)3.01553138
97mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.01423767
98protein localization to chromosome, centromeric region (GO:0071459)3.01419412
99tRNA metabolic process (GO:0006399)3.00122267
100folic acid metabolic process (GO:0046655)3.00086444
101tRNA modification (GO:0006400)3.00024256
102GMP metabolic process (GO:0046037)2.99429426
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.99297555
104low-density lipoprotein particle remodeling (GO:0034374)2.98277639
105ribosomal large subunit biogenesis (GO:0042273)2.98004674
106telomere maintenance via recombination (GO:0000722)2.97372086
107respiratory burst (GO:0045730)2.96385621
108replication fork processing (GO:0031297)2.95462182
109regulation of cellular amino acid metabolic process (GO:0006521)2.94690992
110ribonucleoprotein complex biogenesis (GO:0022613)2.93261017
111signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.93180793
112signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.93180793
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.93180793
114protein targeting to mitochondrion (GO:0006626)2.92950699
115mitotic sister chromatid segregation (GO:0000070)2.91364049
116nicotinamide nucleotide biosynthetic process (GO:0019359)2.90309655
117pyridine nucleotide biosynthetic process (GO:0019363)2.90309655
118establishment of integrated proviral latency (GO:0075713)2.90286054
119purine ribonucleotide transport (GO:0015868)2.89191274
120cellular component biogenesis (GO:0044085)2.88375706
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.87999832
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.87999832
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87665016
124tRNA aminoacylation (GO:0043039)2.87572267
125amino acid activation (GO:0043038)2.87572267
126DNA catabolic process, exonucleolytic (GO:0000738)2.87499526
127ncRNA processing (GO:0034470)2.87142694
128signal transduction involved in DNA damage checkpoint (GO:0072422)2.86967571
129signal transduction involved in DNA integrity checkpoint (GO:0072401)2.86967571
130signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.86916176
131intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.86916176
132bile acid metabolic process (GO:0008206)2.86787598
133translation (GO:0006412)2.85984911
134ncRNA metabolic process (GO:0034660)2.85533546
135folic acid-containing compound biosynthetic process (GO:0009396)2.84574500
136mannosylation (GO:0097502)2.84462578
137mitotic recombination (GO:0006312)2.83878034
138tRNA aminoacylation for protein translation (GO:0006418)2.83639715
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.83430711
140regulation of protein activation cascade (GO:2000257)2.83398034
141glyoxylate metabolic process (GO:0046487)2.83054295
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82738515
143triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82495255
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.82309919
145ATP synthesis coupled proton transport (GO:0015986)2.82058256
146cysteine metabolic process (GO:0006534)2.78859133
147production of molecular mediator involved in inflammatory response (GO:0002532)2.77466543
148plasma lipoprotein particle clearance (GO:0034381)2.77164583
149high-density lipoprotein particle remodeling (GO:0034375)2.74803299
150regulation of fibrinolysis (GO:0051917)2.74024771
151phospholipid efflux (GO:0033700)2.73208501
152urea cycle (GO:0000050)2.71236753
153urea metabolic process (GO:0019627)2.71236753
154nucleotide transport (GO:0006862)2.70977014
155regulation of cholesterol esterification (GO:0010872)2.70903716
156regulation of complement activation (GO:0030449)2.67620973
157detection of other organism (GO:0098543)2.67064571
158G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.65524857
159alpha-linolenic acid metabolic process (GO:0036109)2.65093052
160neutrophil activation involved in immune response (GO:0002283)2.64477490
161plasma lipoprotein particle remodeling (GO:0034369)2.64388925
162protein-lipid complex remodeling (GO:0034368)2.64388925
163macromolecular complex remodeling (GO:0034367)2.64388925
164amino-acid betaine metabolic process (GO:0006577)2.63657646
165negative regulation of lipase activity (GO:0060192)2.61387677
166cofactor catabolic process (GO:0051187)2.60562147
167regulation of triglyceride catabolic process (GO:0010896)2.59841356
168antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.59070381
169detection of external biotic stimulus (GO:0098581)2.57555081
170positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.57277469
171positive regulation of interferon-alpha production (GO:0032727)2.54588283
172blood coagulation, intrinsic pathway (GO:0007597)2.54499482
173regulation of RIG-I signaling pathway (GO:0039535)2.54231117
174opsonization (GO:0008228)2.52964896
175disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.52776930
176killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.52776930
177negative regulation of fibrinolysis (GO:0051918)2.52147875
178acylglycerol homeostasis (GO:0055090)2.51218980
179triglyceride homeostasis (GO:0070328)2.51218980
180alpha-amino acid catabolic process (GO:1901606)2.50319824
181positive regulation of lipoprotein lipase activity (GO:0051006)2.50221547
182positive regulation of triglyceride lipase activity (GO:0061365)2.50221547
183benzene-containing compound metabolic process (GO:0042537)2.48046011
184branched-chain amino acid catabolic process (GO:0009083)2.48025681
185acute-phase response (GO:0006953)2.45849714
186phagocytosis, recognition (GO:0006910)2.45504936
187sulfur amino acid catabolic process (GO:0000098)2.44671936
188drug transmembrane transport (GO:0006855)2.43909524
189very-low-density lipoprotein particle assembly (GO:0034379)2.42932173
190androgen biosynthetic process (GO:0006702)2.42438775
191nitrogen cycle metabolic process (GO:0071941)2.40731376
192regulation of hexokinase activity (GO:1903299)2.40721497
193regulation of glucokinase activity (GO:0033131)2.40721497
194cellular glucuronidation (GO:0052695)2.38954410
195fat-soluble vitamin biosynthetic process (GO:0042362)2.37048209
196positive regulation of antigen processing and presentation (GO:0002579)2.37027585
197coenzyme catabolic process (GO:0009109)2.36033057
198regulation of interferon-alpha production (GO:0032647)2.35432988
199branched-chain amino acid metabolic process (GO:0009081)2.34721661
200protein activation cascade (GO:0072376)2.34106890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.60557831
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.09609121
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.06953694
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.87062482
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.12989547
6IRF8_21731497_ChIP-ChIP_J774_Mouse4.09022364
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.97584860
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90567289
9RXR_22158963_ChIP-Seq_LIVER_Mouse3.85463340
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.73913002
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.42638650
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.36150969
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.33041973
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.21013390
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.12871425
16PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07003054
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.01007029
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.99936628
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.97221202
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93133218
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.88132603
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.87341338
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82541441
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.81664563
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79152791
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73274691
27* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72838877
28* VDR_23849224_ChIP-Seq_CD4+_Human2.70065043
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68649240
30GATA1_22025678_ChIP-Seq_K562_Human2.67987684
31FOXP3_21729870_ChIP-Seq_TREG_Human2.64129744
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63751971
33DCP1A_22483619_ChIP-Seq_HELA_Human2.54353673
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.43492567
35* IRF8_27001747_Chip-Seq_BMDM_Mouse2.39815729
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.36713542
37FOXM1_23109430_ChIP-Seq_U2OS_Human2.30501565
38MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28818325
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26994561
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.26488611
41GABP_19822575_ChIP-Seq_HepG2_Human2.25250464
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25155832
43* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22107731
44XRN2_22483619_ChIP-Seq_HELA_Human2.20058004
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19761375
46* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16472007
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15421348
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12081742
49BP1_19119308_ChIP-ChIP_Hs578T_Human2.11379699
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.10880520
51* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.07283944
52TTF2_22483619_ChIP-Seq_HELA_Human2.06398887
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05221130
54YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90501505
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.81399224
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.80152470
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79550185
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79022317
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75878767
60SCL_19346495_ChIP-Seq_HPC-7_Human1.74673725
61* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.73278496
62E2F1_21310950_ChIP-Seq_MCF-7_Human1.69963593
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69130211
64KDM5A_27292631_Chip-Seq_BREAST_Human1.68918681
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68388156
66MYC_18940864_ChIP-ChIP_HL60_Human1.65058825
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64084670
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63730412
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.55372641
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54921964
71FLI1_27457419_Chip-Seq_LIVER_Mouse1.53047596
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.50294318
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48342792
74CIITA_25753668_ChIP-Seq_RAJI_Human1.47107988
75* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44757763
76ZNF274_21170338_ChIP-Seq_K562_Hela1.44079664
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.44062865
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43461018
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42492420
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41102646
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40191817
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40189265
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39831674
84SPI1_23547873_ChIP-Seq_NB4_Human1.38173941
85STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37634646
86* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34730124
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34267320
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34026825
89STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32999548
90NFE2_27457419_Chip-Seq_LIVER_Mouse1.32355195
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.31562798
92KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30317234
93TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29837437
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.27880550
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27670578
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26579111
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.25812552
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.25226236
99MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25089734
100CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25027720
101SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24490548
102TFEB_21752829_ChIP-Seq_HELA_Human1.21282807
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.20146941
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18500343
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.16979498
106HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14768537
107RUNX1_27457419_Chip-Seq_LIVER_Mouse1.14110004
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13212307
109GATA3_26560356_Chip-Seq_TH2_Human1.12227457
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11551658
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11197479
112PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08699044
113* PU_27001747_Chip-Seq_BMDM_Mouse1.08619498
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08312538
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08245392
116* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08220862
117NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07187196
118PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06889583
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06450694
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06084792
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05985972
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03372889
123GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03043623
124KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01975078
125CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01876496
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01749952
127SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01161379
128* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00983888
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.00892045
130PU1_27457419_Chip-Seq_LIVER_Mouse1.00788161
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00358057
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00321626
133NMYC_18555785_Chip-Seq_ESCs_Mouse0.99879588
134ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97916151
135P53_22387025_ChIP-Seq_ESCs_Mouse0.97734672
136P300_18555785_Chip-Seq_ESCs_Mouse0.97689766
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97574418
138RUNX_20019798_ChIP-Seq_JUKART_Human0.96253930
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.96202401
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95884839
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95601918
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95459432
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95448921
144NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95448921
145OCT4_18555785_Chip-Seq_ESCs_Mouse0.94840824
146TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93377432
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92904911
148ELK1_19687146_ChIP-ChIP_HELA_Human0.92598439
149AR_21909140_ChIP-Seq_LNCAP_Human0.92325250
150PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91333515
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91074533
152CMYC_18555785_Chip-Seq_ESCs_Mouse0.91010976
153PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90769092
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.90200168
155ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89030439
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.88156214
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.87917517
158SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87644174
159PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87052390
160HTT_18923047_ChIP-ChIP_STHdh_Human0.85346018
161IRF1_19129219_ChIP-ChIP_H3396_Human0.85084173
162* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84997468
163CTCF_18555785_Chip-Seq_ESCs_Mouse0.84689417
164SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78638083
165* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76868730
166* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75253537
167* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75166026
168STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74651891
169ELF5_23300383_ChIP-Seq_T47D_Human0.74001798
170KLF4_18555785_ChIP-Seq_MESCs_Mouse0.71032178
171CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.70875335
172CTCF_18555785_ChIP-Seq_MESCs_Mouse0.70389316
173CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68746671
174SOX17_20123909_ChIP-Seq_XEN_Mouse0.68592874
175EWS_26573619_Chip-Seq_HEK293_Human0.64883914
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.64117574
177TP63_19390658_ChIP-ChIP_HaCaT_Human0.64001965
178FOXP1_21924763_ChIP-Seq_HESCs_Human0.63362491
179EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.61486341
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.61012888
181* AR_20517297_ChIP-Seq_VCAP_Human0.59285267
182NANOG_16153702_ChIP-ChIP_HESCs_Human0.59203422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.73394587
2MP0002139_abnormal_hepatobiliary_system4.69367470
3MP0008058_abnormal_DNA_repair4.28440959
4MP0003693_abnormal_embryo_hatching4.27293924
5MP0005360_urolithiasis4.11404940
6MP0003111_abnormal_nucleus_morphology3.99913654
7MP0005085_abnormal_gallbladder_physiolo3.62085514
8MP0003077_abnormal_cell_cycle3.47320210
9MP0004957_abnormal_blastocyst_morpholog3.38820539
10MP0005365_abnormal_bile_salt3.31958277
11MP0003786_premature_aging2.99325492
12MP0008007_abnormal_cellular_replicative2.90824203
13MP0008932_abnormal_embryonic_tissue2.77036098
14MP0003195_calcinosis2.71418659
15MP0003806_abnormal_nucleotide_metabolis2.71083958
16MP0001835_abnormal_antigen_presentation2.68138795
17MP0008875_abnormal_xenobiotic_pharmacok2.58182085
18MP0003718_maternal_effect2.42410951
19MP0003724_increased_susceptibility_to2.08434615
20MP0003252_abnormal_bile_duct2.07340195
21MP0002419_abnormal_innate_immunity2.06047339
22MP0003436_decreased_susceptibility_to2.04798303
23MP0009697_abnormal_copulation2.01835228
24MP0009785_altered_susceptibility_to1.99332623
25MP0006082_CNS_inflammation1.96178057
26MP0003941_abnormal_skin_development1.94802736
27MP0005058_abnormal_lysosome_morphology1.90829274
28MP0006035_abnormal_mitochondrial_morpho1.89447912
29MP0001764_abnormal_homeostasis1.83873057
30MP0009840_abnormal_foam_cell1.82976110
31MP0010329_abnormal_lipoprotein_level1.81308184
32MP0005671_abnormal_response_to1.79369720
33MP0003191_abnormal_cellular_cholesterol1.75102366
34MP0005025_abnormal_response_to1.74674280
35MP0001661_extended_life_span1.74410605
36MP0004782_abnormal_surfactant_physiolog1.74228027
37MP0001666_abnormal_nutrient_absorption1.72627924
38MP0008260_abnormal_autophagy1.72142043
39MP0002148_abnormal_hypersensitivity_rea1.71439110
40MP0002102_abnormal_ear_morphology1.71197608
41MP0003186_abnormal_redox_activity1.70722382
42MP0001790_abnormal_immune_system1.68217479
43MP0005387_immune_system_phenotype1.68217479
44MP0000350_abnormal_cell_proliferation1.67326152
45MP0005464_abnormal_platelet_physiology1.67101084
46MP0005075_abnormal_melanosome_morpholog1.64369171
47MP0005000_abnormal_immune_tolerance1.54714051
48MP0009764_decreased_sensitivity_to1.52158293
49MP0006036_abnormal_mitochondrial_physio1.50137347
50MP0005332_abnormal_amino_acid1.48795055
51MP0002452_abnormal_antigen_presenting1.44269076
52MP0004019_abnormal_vitamin_homeostasis1.44116106
53MP0000358_abnormal_cell_content/1.43425521
54MP0005380_embryogenesis_phenotype1.43171894
55MP0001672_abnormal_embryogenesis/_devel1.43171894
56MP0002138_abnormal_hepatobiliary_system1.42612128
57MP0001800_abnormal_humoral_immune1.42160618
58MP0005408_hypopigmentation1.42071350
59MP0000372_irregular_coat_pigmentation1.39135002
60MP0003868_abnormal_feces_composition1.38675582
61MP0002723_abnormal_immune_serum1.38096817
62MP0008469_abnormal_protein_level1.38077307
63MP0002118_abnormal_lipid_homeostasis1.37641059
64MP0000685_abnormal_immune_system1.37358728
65MP0009333_abnormal_splenocyte_physiolog1.34050641
66MP0000313_abnormal_cell_death1.33665537
67MP0003315_abnormal_perineum_morphology1.32867292
68MP0003172_abnormal_lysosome_physiology1.32722640
69MP0002160_abnormal_reproductive_system1.32512396
70MP0001730_embryonic_growth_arrest1.32115545
71MP0005083_abnormal_biliary_tract1.31170478
72MP0001529_abnormal_vocalization1.30985342
73MP0008057_abnormal_DNA_replication1.30664030
74MP0000609_abnormal_liver_physiology1.29983896
75MP0005174_abnormal_tail_pigmentation1.28320690
76MP0005084_abnormal_gallbladder_morpholo1.27184962
77MP0008789_abnormal_olfactory_epithelium1.27071671
78MP0003984_embryonic_growth_retardation1.25965701
79MP0001819_abnormal_immune_cell1.23890058
80MP0005389_reproductive_system_phenotype1.23659697
81MP0002876_abnormal_thyroid_physiology1.23349565
82MP0002420_abnormal_adaptive_immunity1.23001268
83MP0005319_abnormal_enzyme/_coenzyme1.22621177
84MP0009763_increased_sensitivity_to1.22103122
85MP0010307_abnormal_tumor_latency1.21949747
86MP0000015_abnormal_ear_pigmentation1.21790946
87MP0002019_abnormal_tumor_incidence1.20089829
88MP0008877_abnormal_DNA_methylation1.19957838
89MP0002088_abnormal_embryonic_growth/wei1.19851064
90MP0001845_abnormal_inflammatory_respons1.19192989
91MP0006072_abnormal_retinal_apoptosis1.19051250
92MP0002132_abnormal_respiratory_system1.18207704
93MP0005501_abnormal_skin_physiology1.18037289
94MP0001697_abnormal_embryo_size1.16572752
95MP0009643_abnormal_urine_homeostasis1.16185171
96MP0001293_anophthalmia1.14023461
97MP0003656_abnormal_erythrocyte_physiolo1.12696408
98MP0002095_abnormal_skin_pigmentation1.12002640
99MP0001533_abnormal_skeleton_physiology1.10580698
100MP0003690_abnormal_glial_cell1.09829430
101MP0000490_abnormal_crypts_of1.09581251
102MP0002080_prenatal_lethality1.09553835
103MP0001324_abnormal_eye_pigmentation1.08071030
104MP0002084_abnormal_developmental_patter1.06546141
105MP0005670_abnormal_white_adipose1.06535789
106MP0000647_abnormal_sebaceous_gland1.03934121
107MP0003183_abnormal_peptide_metabolism1.03271735
108MP0001919_abnormal_reproductive_system1.02526947
109MP0000537_abnormal_urethra_morphology1.02039723
110MP0003937_abnormal_limbs/digits/tail_de1.01988723
111MP0010155_abnormal_intestine_physiology1.01679433
112MP0005379_endocrine/exocrine_gland_phen1.01511026
113MP0005451_abnormal_body_composition0.96490048
114MP0005584_abnormal_enzyme/coenzyme_acti0.96072805
115MP0000716_abnormal_immune_system0.95292681
116MP0002877_abnormal_melanocyte_morpholog0.93963687
117MP0002166_altered_tumor_susceptibility0.93058664
118MP0001853_heart_inflammation0.92838683
119MP0002085_abnormal_embryonic_tissue0.92552343
120MP0008438_abnormal_cutaneous_collagen0.92114275
121MP0004381_abnormal_hair_follicle0.90675368
122MP0005647_abnormal_sex_gland0.89610921
123MP0000598_abnormal_liver_morphology0.89472496
124MP0000689_abnormal_spleen_morphology0.89181201
125MP0002090_abnormal_vision0.87496027
126MP0005171_absent_coat_pigmentation0.86624248
127MP0009765_abnormal_xenobiotic_induced0.86300103
128MP0003763_abnormal_thymus_physiology0.85294401
129MP0004133_heterotaxia0.84984485
130MP0004147_increased_porphyrin_level0.83697816
131MP0004197_abnormal_fetal_growth/weight/0.83443511
132MP0002111_abnormal_tail_morphology0.83161733
133MP0002933_joint_inflammation0.83078234
134MP0001145_abnormal_male_reproductive0.82822028
135MP0001542_abnormal_bone_strength0.82465123
136MP0001929_abnormal_gametogenesis0.82222215
137MP0002396_abnormal_hematopoietic_system0.81781476
138MP0002429_abnormal_blood_cell0.81071651
139MP0005253_abnormal_eye_physiology0.80267861
140MP0002398_abnormal_bone_marrow0.80159430
141MP0002277_abnormal_respiratory_mucosa0.79749033
142MP0001881_abnormal_mammary_gland0.79701878
143MP0005636_abnormal_mineral_homeostasis0.78902884
144MP0002938_white_spotting0.78186002
145MP0000920_abnormal_myelination0.77049824
146MP0002210_abnormal_sex_determination0.76698659
147MP0005220_abnormal_exocrine_pancreas0.76500741
148MP0000371_diluted_coat_color0.76264964
149MP0003567_abnormal_fetal_cardiomyocyte0.75786948
150MP0005334_abnormal_fat_pad0.74991516
151MP0002998_abnormal_bone_remodeling0.74900210
152MP0006054_spinal_hemorrhage0.74555867
153MP0001186_pigmentation_phenotype0.74199201
154MP0005499_abnormal_olfactory_system0.74057272
155MP0005394_taste/olfaction_phenotype0.74057272
156MP0002722_abnormal_immune_system0.73982547
157MP0002638_abnormal_pupillary_reflex0.73955700
158MP0005164_abnormal_response_to0.73752609
159MP0000653_abnormal_sex_gland0.73207182
160MP0001119_abnormal_female_reproductive0.71620266
161MP0009642_abnormal_blood_homeostasis0.70926872
162MP0002928_abnormal_bile_duct0.70634644
163MP0002006_tumorigenesis0.70154694
164MP0001545_abnormal_hematopoietic_system0.69923626
165MP0005397_hematopoietic_system_phenotyp0.69923626
166MP0002075_abnormal_coat/hair_pigmentati0.67035029
167MP0000703_abnormal_thymus_morphology0.66699387
168MP0000427_abnormal_hair_cycle0.65767024
169MP0002254_reproductive_system_inflammat0.64811472
170MP0008873_increased_physiological_sensi0.64773669
171MP0002086_abnormal_extraembryonic_tissu0.64045514
172MP0005395_other_phenotype0.62737962
173MP0002796_impaired_skin_barrier0.62120685
174MP0004808_abnormal_hematopoietic_stem0.61768246
175MP0000465_gastrointestinal_hemorrhage0.61050009
176MP0005384_cellular_phenotype0.60428185
177MP0008995_early_reproductive_senescence0.60418817

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.60696064
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.32336607
3Intrahepatic cholestasis (HP:0001406)4.16512797
4Joint hemorrhage (HP:0005261)3.97901244
5Reduced antithrombin III activity (HP:0001976)3.71046922
6Generalized aminoaciduria (HP:0002909)3.67100889
7Recurrent gram-negative bacterial infections (HP:0005420)3.66923508
8Increased CSF lactate (HP:0002490)3.59040388
9Abnormality of the intrinsic pathway (HP:0010989)3.55551176
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.44878394
11Eczematoid dermatitis (HP:0000976)3.43944289
12Lipid accumulation in hepatocytes (HP:0006561)3.41638017
13Abnormal number of erythroid precursors (HP:0012131)3.41365789
14Acute necrotizing encephalopathy (HP:0006965)3.37997789
15Mitochondrial inheritance (HP:0001427)3.34147767
16Hepatocellular necrosis (HP:0001404)3.32012136
17Microvesicular hepatic steatosis (HP:0001414)3.26946469
18Abnormal mitochondria in muscle tissue (HP:0008316)3.24523104
19Hyperlipoproteinemia (HP:0010980)3.23181351
20Increased hepatocellular lipid droplets (HP:0006565)3.22998118
21Xanthomatosis (HP:0000991)3.20234987
22Acute encephalopathy (HP:0006846)3.17421986
23Conjugated hyperbilirubinemia (HP:0002908)3.12954010
24Increased serum lactate (HP:0002151)3.09261863
25Recurrent abscess formation (HP:0002722)3.07327324
26Recurrent bacterial skin infections (HP:0005406)3.03792452
27Abnormality of the common coagulation pathway (HP:0010990)2.96862904
28Hepatic necrosis (HP:0002605)2.95175617
29Abnormality of cells of the erythroid lineage (HP:0012130)2.93214807
30Type I transferrin isoform profile (HP:0003642)2.88698164
31Methylmalonic acidemia (HP:0002912)2.87087804
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.82946126
33Deep venous thrombosis (HP:0002625)2.81141390
34Abnormality of pyrimidine metabolism (HP:0004353)2.80909460
35Birth length less than 3rd percentile (HP:0003561)2.80391407
36Abnormality of methionine metabolism (HP:0010901)2.79622703
37Hypoplasia of the pons (HP:0012110)2.78522754
38Systemic lupus erythematosus (HP:0002725)2.74922628
39Complement deficiency (HP:0004431)2.74608612
40Methylmalonic aciduria (HP:0012120)2.74061989
41Meckel diverticulum (HP:0002245)2.73299700
42Abnormality of fatty-acid metabolism (HP:0004359)2.68335948
43Hypobetalipoproteinemia (HP:0003563)2.66885267
44Colon cancer (HP:0003003)2.65528494
45Gingival bleeding (HP:0000225)2.65241354
46Fat malabsorption (HP:0002630)2.63649712
47Abnormality of the ileum (HP:0001549)2.63017050
48Lactic acidosis (HP:0003128)2.59755301
49Abnormality of alanine metabolism (HP:0010916)2.59259565
50Hyperalaninemia (HP:0003348)2.59259565
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59259565
52Aplasia/hypoplasia of the uterus (HP:0008684)2.55847338
53Renal cortical cysts (HP:0000803)2.53495270
54Abnormality of the pons (HP:0007361)2.53142366
55Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51175198
56Progressive macrocephaly (HP:0004481)2.47964856
57Pancreatic cysts (HP:0001737)2.43095816
58Prostate neoplasm (HP:0100787)2.43046149
59Vacuolated lymphocytes (HP:0001922)2.42494148
60Abnormality of serum amino acid levels (HP:0003112)2.42025617
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.39294501
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39263079
63Renal Fanconi syndrome (HP:0001994)2.39229294
64Abnormality of the preputium (HP:0100587)2.38480458
65Steatorrhea (HP:0002570)2.38299482
66Poor head control (HP:0002421)2.38253776
67Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.35871595
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.35871595
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.35076986
70Epistaxis (HP:0000421)2.33012012
71* Abnormal protein glycosylation (HP:0012346)2.33008193
72* Abnormal glycosylation (HP:0012345)2.33008193
73* Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.33008193
74* Abnormal protein N-linked glycosylation (HP:0012347)2.33008193
75Hepatosplenomegaly (HP:0001433)2.31779977
76Patchy hypopigmentation of hair (HP:0011365)2.30790770
77Pancytopenia (HP:0001876)2.30503277
78Cerebral edema (HP:0002181)2.29814713
793-Methylglutaconic aciduria (HP:0003535)2.26195754
80Recurrent skin infections (HP:0001581)2.25558309
81Abnormality of the prostate (HP:0008775)2.25242466
82Increased intramyocellular lipid droplets (HP:0012240)2.23094326
83Hypothermia (HP:0002045)2.21441649
84Opisthotonus (HP:0002179)2.21009637
85Progressive muscle weakness (HP:0003323)2.18849176
86Hyperbilirubinemia (HP:0002904)2.18641447
87Type II lissencephaly (HP:0007260)2.17378795
88Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17065438
89Abnormality of glycine metabolism (HP:0010895)2.15844357
90Abnormality of serine family amino acid metabolism (HP:0010894)2.15844357
91Horseshoe kidney (HP:0000085)2.15513632
92Respiratory difficulties (HP:0002880)2.15105426
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13935355
94Epidermoid cyst (HP:0200040)2.13455609
95Abnormality of chromosome stability (HP:0003220)2.13440415
96Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.13206284
97Hypoplasia of the uterus (HP:0000013)2.12614496
98Myocardial infarction (HP:0001658)2.12470780
99Hypoglycemic coma (HP:0001325)2.11764300
100White forelock (HP:0002211)2.11711737
101Abnormality of complement system (HP:0005339)2.11069451
102Cleft eyelid (HP:0000625)2.10805588
103Abnormality of macrophages (HP:0004311)2.10244879
104Axonal loss (HP:0003447)2.09169915
105Purpura (HP:0000979)2.08261445
106Increased serum pyruvate (HP:0003542)2.06960127
107Abnormality of nucleobase metabolism (HP:0010932)2.06498896
108Thrombocytosis (HP:0001894)2.05289516
109Prolonged neonatal jaundice (HP:0006579)2.04524237
110Pendular nystagmus (HP:0012043)2.04300187
111Reticulocytopenia (HP:0001896)2.03983073
112Elevated alkaline phosphatase (HP:0003155)2.03875689
113Microretrognathia (HP:0000308)2.03873804
114Squamous cell carcinoma (HP:0002860)2.02707520
115Menorrhagia (HP:0000132)2.01935362
116Death in infancy (HP:0001522)2.00545549
117Increased muscle lipid content (HP:0009058)1.99696747
118Sloping forehead (HP:0000340)1.99546041
119Vasculitis (HP:0002633)1.99410447
120Abnormality of the renal cortex (HP:0011035)1.98904826
121Sparse eyelashes (HP:0000653)1.98827058
122Dicarboxylic aciduria (HP:0003215)1.98449218
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98449218
124Recurrent pneumonia (HP:0006532)1.98398709
125Prolonged bleeding time (HP:0003010)1.97429180
126Myositis (HP:0100614)1.97313166
127Symptomatic seizures (HP:0011145)1.97255137
128Periodontitis (HP:0000704)1.96754127
129Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96281718
130Abnormality of glycolysis (HP:0004366)1.95712138
131IgM deficiency (HP:0002850)1.95679134
132Hyperammonemia (HP:0001987)1.95219303
133Vascular calcification (HP:0004934)1.94728796
134Pancreatic fibrosis (HP:0100732)1.93774869
135Lethargy (HP:0001254)1.93555320
136Orchitis (HP:0100796)1.93429650
137Increased neuronal autofluorescent lipopigment (HP:0002074)1.93179755
138Absent thumb (HP:0009777)1.91889216
139Macrocytic anemia (HP:0001972)1.91761346
140Enlarged kidneys (HP:0000105)1.91634582
141Congenital, generalized hypertrichosis (HP:0004540)1.90553832
142Abnormality of the renal collecting system (HP:0004742)1.90051323
143Abnormal enzyme/coenzyme activity (HP:0012379)1.89451622
144CNS demyelination (HP:0007305)1.88709816
145Rough bone trabeculation (HP:0100670)1.88602065
146Selective tooth agenesis (HP:0001592)1.88067126
147Retrobulbar optic neuritis (HP:0100654)1.87604016
148Optic neuritis (HP:0100653)1.87604016
149Medial flaring of the eyebrow (HP:0010747)1.87549933
150Glomerulonephritis (HP:0000099)1.87358043
151Postnatal microcephaly (HP:0005484)1.87331958
152Hypolipoproteinemia (HP:0010981)1.87221391
153Testicular atrophy (HP:0000029)1.87185431
154Small intestinal stenosis (HP:0012848)1.86517765
155Duodenal stenosis (HP:0100867)1.86517765
156Progressive microcephaly (HP:0000253)1.86021937
157Gingivitis (HP:0000230)1.84470461
158Respiratory failure (HP:0002878)1.84441369
159Proximal tubulopathy (HP:0000114)1.84341886
160CNS hypomyelination (HP:0003429)1.83136304
161IgG deficiency (HP:0004315)1.83102783
162Neutropenia (HP:0001875)1.82707334
163Myelodysplasia (HP:0002863)1.82427274
164Chromsome breakage (HP:0040012)1.81554606
165Nausea (HP:0002018)1.81423342
166Hyperglycinuria (HP:0003108)1.81293422
167Alveolar cell carcinoma (HP:0006519)1.81204790
168Abnormal biliary tract physiology (HP:0012439)1.80516909
169Bile duct proliferation (HP:0001408)1.80516909
170Degeneration of anterior horn cells (HP:0002398)1.80494866
171Abnormality of the anterior horn cell (HP:0006802)1.80494866
172Entropion (HP:0000621)1.80220934
173Abnormality of alkaline phosphatase activity (HP:0004379)1.79840228
174Congenital primary aphakia (HP:0007707)1.78538931
175Hypercholesterolemia (HP:0003124)1.78497981
176Nonimmune hydrops fetalis (HP:0001790)1.77824867
177Recurrent fungal infections (HP:0002841)1.77765665
178Elevated hepatic transaminases (HP:0002910)1.77514363
179Hypoplasia of the thymus (HP:0000778)1.77181144
180Granulocytopenia (HP:0001913)1.77110126
181Autoimmune thrombocytopenia (HP:0001973)1.76952633
182Hyperglycinemia (HP:0002154)1.76735070
183Secondary amenorrhea (HP:0000869)1.76251505
184Exertional dyspnea (HP:0002875)1.75718353
185Brittle hair (HP:0002299)1.75289421
186Abnormality of midbrain morphology (HP:0002418)1.74763042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.49125713
2SRPK14.33111434
3BUB13.86463614
4IRAK33.75144565
5NEK13.11254009
6IRAK43.01564792
7CDC72.99248002
8MAP3K142.58532964
9EPHB12.53457261
10ERN12.44257214
11FGFR42.22032678
12TTK2.18705293
13TXK2.11074251
14ZAK2.04509159
15FRK1.97306665
16BMPR1B1.96731791
17STK161.93502909
18IRAK11.92089032
19EPHA31.84332374
20TAF11.84298774
21BMPR21.82940394
22MAP4K21.82708797
23TYK21.82468406
24CDK81.82078506
25KIT1.81745141
26PBK1.74823511
27PLK31.72570498
28PLK41.72313275
29TRPM71.68368300
30MKNK11.65894110
31TBK11.64601395
32IKBKE1.63653936
33MAP4K11.57244460
34BCKDK1.55998383
35BLK1.54269495
36TAOK31.49784973
37JAK31.47743367
38MST41.47384489
39TGFBR21.46862134
40NUAK11.46665803
41CHEK21.45692715
42TEC1.43108747
43JAK11.39260274
44IKBKB1.38903823
45EIF2AK31.37205183
46NME11.36163474
47INSRR1.35809063
48PLK11.31580736
49BTK1.29898946
50TRIM281.28923360
51MKNK21.25494803
52STK241.25342363
53RPS6KA41.24102829
54CSNK1G11.22980779
55NLK1.22559694
56TSSK61.22138130
57EIF2AK21.19984370
58GRK11.19760567
59CSF1R1.19650726
60CSNK1G31.16153794
61AURKB1.14354384
62CDK71.10323014
63NEK21.08903969
64CLK11.08130564
65WEE11.06539345
66CAMK1D1.05630681
67BRSK21.03514161
68CDK91.03239306
69NEK61.01681113
70ERBB30.99422869
71MAP3K40.98374496
72WNK30.97325208
73MAP2K70.97193231
74CSNK1A1L0.96997267
75NEK90.94292043
76LYN0.92021472
77AURKA0.91715787
78TGFBR10.89297176
79ZAP700.89168564
80STK30.87705556
81YES10.87597306
82PRPF4B0.86550861
83EIF2AK10.83458037
84IRAK20.82929502
85CHEK10.82175745
86MAPK110.81957621
87PKN10.78357571
88LCK0.78109314
89CDK40.77993399
90PASK0.77873378
91WNK40.77526710
92SMG10.77153278
93MAPK150.76416950
94ADRBK20.75384065
95CHUK0.75294737
96FGFR30.75233876
97TESK20.73603496
98OXSR10.73167633
99BRSK10.72892686
100ATM0.70879582
101CSK0.70791046
102MATK0.70648970
103ITK0.69135932
104STK38L0.68134101
105MAPKAPK50.67805572
106CSNK1G20.67763478
107PIK3CG0.66412300
108SYK0.65256287
109GRK70.64598616
110JAK20.64447835
111PIM10.63786222
112PIM20.61951326
113RPS6KB20.61796430
114NME20.61739186
115CSNK2A10.61708382
116PDK20.61413712
117DYRK20.61255622
118ERBB40.61028693
119PAK40.60309371
120STK40.57057210
121CSNK2A20.56450751
122ABL20.55217288
123HCK0.54908258
124MST1R0.54705713
125PRKCD0.54127099
126KDR0.53721474
127FLT30.53065421
128PRKCQ0.52687302
129PRKG20.52659397
130CDK190.52147417
131GRK60.51399223
132ABL10.51024365
133VRK10.50739967
134DAPK10.47278515
135HIPK20.46706822
136MAP3K80.43915951
137DYRK30.43485369
138LIMK10.42574126
139STK390.42498701
140MUSK0.41513653
141RPS6KA50.40977366
142MAP2K30.40413772
143SIK30.38144757
144MAP2K20.37849346
145IGF1R0.37597968
146ATR0.37369802
147PRKCI0.36716762
148CDK60.34990679
149TLK10.34898434
150EPHA20.34869151
151STK100.34455302
152CDK10.34153001
153MAPK70.33713554
154MELK0.33617222
155ADRBK10.33013399
156CDK20.32111877
157CSNK1A10.25475853

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.15189245
2RNA polymerase_Homo sapiens_hsa030203.14285744
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.06831865
4Ribosome_Homo sapiens_hsa030102.96194992
5Mismatch repair_Homo sapiens_hsa034302.85305694
6Homologous recombination_Homo sapiens_hsa034402.81955940
7Base excision repair_Homo sapiens_hsa034102.79927520
8Steroid biosynthesis_Homo sapiens_hsa001002.62995216
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.58961603
10Histidine metabolism_Homo sapiens_hsa003402.30820719
11Spliceosome_Homo sapiens_hsa030402.30783412
12Staphylococcus aureus infection_Homo sapiens_hsa051502.29739464
13Complement and coagulation cascades_Homo sapiens_hsa046102.26116496
14Oxidative phosphorylation_Homo sapiens_hsa001902.25117523
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.12726413
16Tryptophan metabolism_Homo sapiens_hsa003802.10533103
17Sulfur metabolism_Homo sapiens_hsa009202.10491235
18Peroxisome_Homo sapiens_hsa041462.09159454
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09146525
20Nucleotide excision repair_Homo sapiens_hsa034202.08170184
21RNA transport_Homo sapiens_hsa030132.07691219
22Fanconi anemia pathway_Homo sapiens_hsa034602.02348434
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.99290969
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96999798
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.94353283
26Protein export_Homo sapiens_hsa030601.91616041
27Parkinsons disease_Homo sapiens_hsa050121.91477056
28beta-Alanine metabolism_Homo sapiens_hsa004101.86713279
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.83082469
30Basal transcription factors_Homo sapiens_hsa030221.81274773
31Retinol metabolism_Homo sapiens_hsa008301.81272586
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78529812
33Fatty acid degradation_Homo sapiens_hsa000711.76717291
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.73237315
35Fatty acid elongation_Homo sapiens_hsa000621.71138130
36RNA degradation_Homo sapiens_hsa030181.66155439
37Propanoate metabolism_Homo sapiens_hsa006401.65312727
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60358872
39Chemical carcinogenesis_Homo sapiens_hsa052041.57945368
40Drug metabolism - other enzymes_Homo sapiens_hsa009831.57481132
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54197941
42Folate biosynthesis_Homo sapiens_hsa007901.53372177
43ABC transporters_Homo sapiens_hsa020101.51995811
44Selenocompound metabolism_Homo sapiens_hsa004501.51186649
45Huntingtons disease_Homo sapiens_hsa050161.50728679
46Vitamin digestion and absorption_Homo sapiens_hsa049771.48477429
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48382195
48Caffeine metabolism_Homo sapiens_hsa002321.46044860
49Cell cycle_Homo sapiens_hsa041101.45219351
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.45005643
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41830209
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38684136
53Purine metabolism_Homo sapiens_hsa002301.33114672
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.28265340
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27439458
56Tyrosine metabolism_Homo sapiens_hsa003501.25228842
57Phenylalanine metabolism_Homo sapiens_hsa003601.23428140
58One carbon pool by folate_Homo sapiens_hsa006701.20411104
59Fatty acid metabolism_Homo sapiens_hsa012121.15856477
60PPAR signaling pathway_Homo sapiens_hsa033201.15830620
61Starch and sucrose metabolism_Homo sapiens_hsa005001.09508060
62Vitamin B6 metabolism_Homo sapiens_hsa007501.09327970
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07274476
64Arginine biosynthesis_Homo sapiens_hsa002201.05874504
65Legionellosis_Homo sapiens_hsa051341.05255439
66Alzheimers disease_Homo sapiens_hsa050101.04656155
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04383924
68p53 signaling pathway_Homo sapiens_hsa041151.02419864
69Butanoate metabolism_Homo sapiens_hsa006501.00260716
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00107998
71Arachidonic acid metabolism_Homo sapiens_hsa005900.99451513
72Non-homologous end-joining_Homo sapiens_hsa034500.94493476
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92832663
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.92564745
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92558167
76Lysosome_Homo sapiens_hsa041420.91644189
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.90880419
78Leishmaniasis_Homo sapiens_hsa051400.90792839
79Malaria_Homo sapiens_hsa051440.90356868
80mRNA surveillance pathway_Homo sapiens_hsa030150.89434232
81Arginine and proline metabolism_Homo sapiens_hsa003300.89200360
82Other glycan degradation_Homo sapiens_hsa005110.87746645
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83250574
84Pertussis_Homo sapiens_hsa051330.82892926
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82641804
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80346832
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.79768408
88Measles_Homo sapiens_hsa051620.78410510
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77812067
90Biosynthesis of amino acids_Homo sapiens_hsa012300.77565425
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.76235539
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74103898
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73448458
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.72882845
95Graft-versus-host disease_Homo sapiens_hsa053320.72135305
96Phagosome_Homo sapiens_hsa041450.71666515
97Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69353558
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65761364
99Hematopoietic cell lineage_Homo sapiens_hsa046400.65388436
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65151438
101Linoleic acid metabolism_Homo sapiens_hsa005910.64721939
102Sulfur relay system_Homo sapiens_hsa041220.62467346
103Epstein-Barr virus infection_Homo sapiens_hsa051690.62019574
104Metabolic pathways_Homo sapiens_hsa011000.60347537
105Glutathione metabolism_Homo sapiens_hsa004800.59999749
106Primary immunodeficiency_Homo sapiens_hsa053400.59653307
107Allograft rejection_Homo sapiens_hsa053300.57404087
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57139529
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56161209
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55586805
111Proteasome_Homo sapiens_hsa030500.55582990
112Sphingolipid metabolism_Homo sapiens_hsa006000.55527728
113Rheumatoid arthritis_Homo sapiens_hsa053230.54154225
114Carbon metabolism_Homo sapiens_hsa012000.53621053
115Autoimmune thyroid disease_Homo sapiens_hsa053200.52222767
116Ether lipid metabolism_Homo sapiens_hsa005650.51388039
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.50133061
118N-Glycan biosynthesis_Homo sapiens_hsa005100.49276524
119Phototransduction_Homo sapiens_hsa047440.48822163
120Systemic lupus erythematosus_Homo sapiens_hsa053220.48806908
121Herpes simplex infection_Homo sapiens_hsa051680.48805952
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.46601134
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45212556
1242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43819551
125Hepatitis C_Homo sapiens_hsa051600.43770029
126Tuberculosis_Homo sapiens_hsa051520.43488316
127Pentose phosphate pathway_Homo sapiens_hsa000300.41953693
128Glycerolipid metabolism_Homo sapiens_hsa005610.41173305
129Fat digestion and absorption_Homo sapiens_hsa049750.38507778
130Pyrimidine metabolism_Homo sapiens_hsa002400.38313138
131TNF signaling pathway_Homo sapiens_hsa046680.38129988
132Pyruvate metabolism_Homo sapiens_hsa006200.37404537
133DNA replication_Homo sapiens_hsa030300.36595530
134Influenza A_Homo sapiens_hsa051640.36295403
135Asthma_Homo sapiens_hsa053100.35045292
136Lysine degradation_Homo sapiens_hsa003100.33974220
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.27321617
138Nitrogen metabolism_Homo sapiens_hsa009100.20563203
139Oocyte meiosis_Homo sapiens_hsa041140.19953498
140Viral carcinogenesis_Homo sapiens_hsa052030.19424324
141Shigellosis_Homo sapiens_hsa051310.19215443
142Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18293322
143Galactose metabolism_Homo sapiens_hsa000520.16953687

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »