RFTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.15234893
2antigen processing and presentation of endogenous antigen (GO:0019883)5.79468527
3positive regulation of gamma-delta T cell activation (GO:0046645)5.75262817
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.60794108
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.60794108
6NIK/NF-kappaB signaling (GO:0038061)5.00466284
7neutrophil activation involved in immune response (GO:0002283)4.35347240
8cellular response to zinc ion (GO:0071294)4.32499213
9regulation of gamma-delta T cell differentiation (GO:0045586)4.30199100
10positive regulation of B cell differentiation (GO:0045579)4.29496359
11regulation of gamma-delta T cell activation (GO:0046643)4.07409545
12CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.99441011
13myeloid dendritic cell differentiation (GO:0043011)3.96511236
14regulation of interleukin-12 biosynthetic process (GO:0045075)3.95508353
15regulation of B cell receptor signaling pathway (GO:0050855)3.92635777
16T-helper 1 type immune response (GO:0042088)3.92625898
17myeloid dendritic cell activation (GO:0001773)3.92026808
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.91004039
19regulation of B cell differentiation (GO:0045577)3.90939663
20negative thymic T cell selection (GO:0045060)3.78640951
21regulation of T-helper 1 cell differentiation (GO:0045625)3.77521027
22defense response to protozoan (GO:0042832)3.75053753
23* B cell receptor signaling pathway (GO:0050853)3.70510186
24immunoglobulin mediated immune response (GO:0016064)3.68461127
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64542756
26mature B cell differentiation (GO:0002335)3.64418813
27negative T cell selection (GO:0043383)3.60263039
28response to type I interferon (GO:0034340)3.57156919
29neutrophil activation (GO:0042119)3.57022121
30antigen processing and presentation via MHC class Ib (GO:0002475)3.56628577
31cellular response to type I interferon (GO:0071357)3.55570369
32type I interferon signaling pathway (GO:0060337)3.55570369
33macrophage activation involved in immune response (GO:0002281)3.49862564
34T cell migration (GO:0072678)3.48985101
35response to muramyl dipeptide (GO:0032495)3.47418334
36granulocyte activation (GO:0036230)3.46978768
37positive regulation of natural killer cell differentiation (GO:0032825)3.46170686
38positive regulation of antigen processing and presentation (GO:0002579)3.45677414
39regulation of necroptotic process (GO:0060544)3.44947407
40positive regulation of interleukin-2 production (GO:0032743)3.43445235
41B cell proliferation (GO:0042100)3.41497462
42mast cell activation (GO:0045576)3.39314082
43positive regulation of interferon-alpha production (GO:0032727)3.37316540
44response to protozoan (GO:0001562)3.36956948
45interferon-gamma-mediated signaling pathway (GO:0060333)3.36937433
46regulation of interferon-beta biosynthetic process (GO:0045357)3.36173637
47positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.35674706
48positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.34462135
49B cell homeostasis (GO:0001782)3.34085372
50positive regulation of type 2 immune response (GO:0002830)3.33625660
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30936961
52response to interleukin-15 (GO:0070672)3.29212449
53positive thymic T cell selection (GO:0045059)3.28738120
54regulation of interferon-alpha production (GO:0032647)3.25591934
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25284643
56leukocyte aggregation (GO:0070486)3.24704898
57dendritic cell differentiation (GO:0097028)3.23767069
58regulation of interleukin-2 biosynthetic process (GO:0045076)3.22388996
59ribosomal small subunit assembly (GO:0000028)3.18264274
60B cell mediated immunity (GO:0019724)3.17047536
61regulation of interferon-gamma biosynthetic process (GO:0045072)3.15334303
62cellular response to interferon-gamma (GO:0071346)3.15293035
63respiratory burst (GO:0045730)3.14340743
64regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.14148248
65cellular response to interleukin-15 (GO:0071350)3.11476590
66response to peptidoglycan (GO:0032494)3.10576894
67natural killer cell mediated cytotoxicity (GO:0042267)3.10311459
68natural killer cell mediated immunity (GO:0002228)3.10311459
69regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.10256643
70regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10063783
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08870397
72negative regulation of erythrocyte differentiation (GO:0045647)3.08858726
73mature B cell differentiation involved in immune response (GO:0002313)3.07803261
74detection of bacterium (GO:0016045)3.07796409
75regulation of vitamin D biosynthetic process (GO:0060556)3.07546891
76regulation of alpha-beta T cell proliferation (GO:0046640)3.07018728
77detection of other organism (GO:0098543)3.05542892
78negative regulation of necroptotic process (GO:0060546)3.04869030
79regulation of antigen processing and presentation (GO:0002577)3.01990284
80regulation of RIG-I signaling pathway (GO:0039535)3.01019461
81myeloid cell activation involved in immune response (GO:0002275)3.00747888
82regulation of type I interferon-mediated signaling pathway (GO:0060338)3.00502022
83T cell homeostasis (GO:0043029)3.00088728
84positive regulation of B cell proliferation (GO:0030890)2.99652360
85regulation of T-helper cell differentiation (GO:0045622)2.98609382
86lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97430421
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97161218
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.97161218
89modulation by symbiont of host immune response (GO:0052553)2.97161218
90positive regulation by symbiont of host defense response (GO:0052509)2.97161218
91modulation by symbiont of host defense response (GO:0052031)2.97161218
92modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97161218
93lymph node development (GO:0048535)2.96639428
94T cell costimulation (GO:0031295)2.96067042
95response to interferon-beta (GO:0035456)2.95989041
96thymic T cell selection (GO:0045061)2.95910120
97positive regulation of T cell cytokine production (GO:0002726)2.95364365
98positive regulation of interleukin-12 production (GO:0032735)2.93402772
99positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.91080357
100lymphocyte costimulation (GO:0031294)2.91039338
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.90687385
102regulation of tolerance induction (GO:0002643)2.90494564
103regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90220831
104germinal center formation (GO:0002467)2.90159778
105natural killer cell differentiation (GO:0001779)2.89751790
106regulation of T cell receptor signaling pathway (GO:0050856)2.86325189
107positive regulation of macrophage differentiation (GO:0045651)2.86296190
108positive regulation of macrophage cytokine production (GO:0060907)2.85378752
109positive regulation of alpha-beta T cell proliferation (GO:0046641)2.83526723
110negative regulation of T cell mediated immunity (GO:0002710)2.83063355
111regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.82920274
112positive regulation of T-helper cell differentiation (GO:0045624)2.82704067
113cellular response to interferon-beta (GO:0035458)2.81993608
114negative regulation of cell killing (GO:0031342)2.81923781
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81923781
116regulation of T cell tolerance induction (GO:0002664)2.81794890
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.81051660
118response to interferon-gamma (GO:0034341)2.80802822
119regulation of B cell proliferation (GO:0030888)2.79495873
120negative regulation of interleukin-12 production (GO:0032695)2.78933162
121activation of MAPKKK activity (GO:0000185)2.78872649
122positive regulation of B cell activation (GO:0050871)2.78537538
123regulation of interleukin-12 production (GO:0032655)2.77563928
124myeloid leukocyte activation (GO:0002274)2.75956523
125T cell selection (GO:0045058)2.74762977
126T cell lineage commitment (GO:0002360)2.74710848
127leukocyte degranulation (GO:0043299)2.73549691
128positive regulation of humoral immune response (GO:0002922)2.72566425
129positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.72533686
130regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.72458939
131response to interferon-alpha (GO:0035455)2.72300289
132regulation of type 2 immune response (GO:0002828)2.71500063
133regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70906429
134negative regulation of T-helper cell differentiation (GO:0045623)2.70497210
135positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.69773438
136positive regulation of cytokine biosynthetic process (GO:0042108)2.69621836
137regulation of T-helper 2 cell differentiation (GO:0045628)2.68748170

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.90631885
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.62833505
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.61791084
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.27663061
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.11096279
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67581609
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.66529489
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.36590706
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33415497
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.19769167
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.01954008
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.92301156
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.90057070
14SCL_19346495_ChIP-Seq_HPC-7_Human2.83606817
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.80677576
16VDR_21846776_ChIP-Seq_THP-1_Human2.73977640
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.62804421
18* MYC_22102868_ChIP-Seq_BL_Human2.52853954
19* MYB_26560356_Chip-Seq_TH2_Human2.48675973
20* MAF_26560356_Chip-Seq_TH1_Human2.44025430
21RUNX_20019798_ChIP-Seq_JUKART_Human2.43759880
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.42192513
23* SPI1_23547873_ChIP-Seq_NB4_Human2.37990052
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.34062250
25* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.33639465
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30441134
27VDR_24763502_ChIP-Seq_THP-1_Human2.28930459
28* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20313981
29E2F7_22180533_ChIP-Seq_HELA_Human2.19845296
30* MYB_26560356_Chip-Seq_TH1_Human2.15314369
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.07118395
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01213182
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00503808
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92841487
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90051639
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87659248
37UTX_26944678_Chip-Seq_JUKART_Human1.87505432
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.83649323
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.81068741
40* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78749621
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.74087806
42SPI1_23127762_ChIP-Seq_K562_Human1.74059640
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70699123
44GATA1_22025678_ChIP-Seq_K562_Human1.70338639
45TCF7_22412390_ChIP-Seq_EML_Mouse1.69744213
46LXR_22292898_ChIP-Seq_THP-1_Human1.64885529
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.60328340
48MAF_26560356_Chip-Seq_TH2_Human1.59163466
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55959614
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53556575
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52406939
52* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.50454165
53GATA3_27048872_Chip-Seq_THYMUS_Human1.47976661
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47305129
55* PU_27001747_Chip-Seq_BMDM_Mouse1.44255147
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.42819306
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.40605707
58RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40217339
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38636545
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37516024
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37446212
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37024976
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36210333
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35504197
65* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34558627
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31444915
67* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29460135
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27263295
69* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27140609
70* KDM2B_26808549_Chip-Seq_DND41_Human1.26210966
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25136522
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19978337
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18487040
74GATA3_26560356_Chip-Seq_TH2_Human1.18085695
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16916231
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16732800
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.16053107
78TP63_17297297_ChIP-ChIP_HaCaT_Human1.14246055
79* GATA1_19941827_ChIP-Seq_MEL_Mouse1.14087788
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.13172497
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11525788
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09580372
83VDR_24787735_ChIP-Seq_THP-1_Human1.07537739
84PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06859419
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06131213
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04391949
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03839402
88TFEB_21752829_ChIP-Seq_HELA_Human1.01173604
89* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99515817
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98788623
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96853823
92PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96810571
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94076314
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92749105
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92483221
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.92197602
97STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90426152
98VDR_23849224_ChIP-Seq_CD4+_Human0.90349225
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88472337
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88274872
101CIITA_25753668_ChIP-Seq_RAJI_Human0.85800856
102GATA1_19941826_ChIP-Seq_K562_Human0.83330644
103NCOR1_26117541_ChIP-Seq_K562_Human0.82293709
104CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81432885
105* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81108717
106KDM2B_26808549_Chip-Seq_K562_Human0.79052889
107CLOCK_20551151_ChIP-Seq_293T_Human0.76652198
108BCOR_27268052_Chip-Seq_Bcells_Human0.75998398
109TP53_22127205_ChIP-Seq_IMR90_Human0.75056121
110* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74970060
111* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74291049
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74209141
113CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74048071
114ELF1_20517297_ChIP-Seq_JURKAT_Human0.73792887
115SPI1_20517297_ChIP-Seq_HL60_Human0.73589540
116RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72175583
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71312751
118* CTCF_26484167_Chip-Seq_Bcells_Mouse0.69089216
119BCL6_27268052_Chip-Seq_Bcells_Human0.68676725
120FOXP3_21729870_ChIP-Seq_TREG_Human0.68667512
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.67823784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.82302721
2MP0000685_abnormal_immune_system3.93974882
3MP0001790_abnormal_immune_system3.43851612
4MP0005387_immune_system_phenotype3.43851612
5MP0005671_abnormal_response_to3.30792784
6* MP0001800_abnormal_humoral_immune3.18086436
7* MP0005000_abnormal_immune_tolerance3.07160164
8MP0002148_abnormal_hypersensitivity_rea3.01780434
9MP0004510_myositis2.96375301
10MP0009785_altered_susceptibility_to2.94397604
11* MP0002452_abnormal_antigen_presenting2.93807630
12MP0003436_decreased_susceptibility_to2.89081323
13MP0003303_peritoneal_inflammation2.82519269
14* MP0002723_abnormal_immune_serum2.80743171
15MP0005025_abnormal_response_to2.74058981
16* MP0002420_abnormal_adaptive_immunity2.66421417
17* MP0001819_abnormal_immune_cell2.65155432
18MP0002419_abnormal_innate_immunity2.63569775
19MP0002166_altered_tumor_susceptibility2.56869619
20MP0003763_abnormal_thymus_physiology2.41075466
21* MP0002398_abnormal_bone_marrow2.32304234
22MP0003724_increased_susceptibility_to2.25059514
23* MP0000716_abnormal_immune_system2.19310542
24MP0002006_tumorigenesis2.12961120
25MP0006082_CNS_inflammation2.10046859
26MP0002396_abnormal_hematopoietic_system2.06932509
27MP0002405_respiratory_system_inflammati2.00554280
28MP0001853_heart_inflammation1.97074766
29MP0005464_abnormal_platelet_physiology1.94252137
30* MP0000689_abnormal_spleen_morphology1.87661922
31MP0001873_stomach_inflammation1.84275651
32* MP0002429_abnormal_blood_cell1.82256662
33MP0002722_abnormal_immune_system1.81716685
34MP0010155_abnormal_intestine_physiology1.78078213
35MP0005310_abnormal_salivary_gland1.74530748
36MP0001348_abnormal_lacrimal_gland1.72999632
37MP0005058_abnormal_lysosome_morphology1.71092418
38MP0002138_abnormal_hepatobiliary_system1.69930550
39MP0008438_abnormal_cutaneous_collagen1.65799762
40MP0001845_abnormal_inflammatory_respons1.65062435
41MP0005451_abnormal_body_composition1.64823956
42MP0004808_abnormal_hematopoietic_stem1.61774120
43MP0004947_skin_inflammation1.59989713
44MP0009333_abnormal_splenocyte_physiolog1.59271844
45MP0002933_joint_inflammation1.53140239
46MP0005397_hematopoietic_system_phenotyp1.51267976
47MP0001545_abnormal_hematopoietic_system1.51267976
48MP0003300_gastrointestinal_ulcer1.48839150
49MP0005174_abnormal_tail_pigmentation1.48293572
50MP0000703_abnormal_thymus_morphology1.44768242
51MP0001533_abnormal_skeleton_physiology1.42063792
52MP0000465_gastrointestinal_hemorrhage1.31802332
53MP0008469_abnormal_protein_level1.31675387
54MP0003866_abnormal_defecation1.29082399
55MP0003448_altered_tumor_morphology1.26614508
56MP0003172_abnormal_lysosome_physiology1.23997481
57MP0002009_preneoplasia1.22710276
58MP0009278_abnormal_bone_marrow1.19282401
59MP0008057_abnormal_DNA_replication1.10233678
60MP0003828_pulmonary_edema1.08168511
61MP0000343_altered_response_to1.07937857
62MP0003705_abnormal_hypodermis_morpholog1.06308322
63MP0002254_reproductive_system_inflammat1.06230414
64MP0003183_abnormal_peptide_metabolism1.06229197
65MP0002998_abnormal_bone_remodeling1.03749770
66MP0005623_abnormal_meninges_morphology1.03248998
67MP0002332_abnormal_exercise_endurance1.03029537
68MP0001542_abnormal_bone_strength1.00773532
69MP0003045_fibrosis0.99865639
70MP0002139_abnormal_hepatobiliary_system0.96815137
71MP0008004_abnormal_stomach_pH0.96070669
72MP0008874_decreased_physiological_sensi0.95790133
73MP0000490_abnormal_crypts_of0.94855311
74MP0000858_altered_metastatic_potential0.93966684
75MP0009764_decreased_sensitivity_to0.91239717
76MP0010352_gastrointestinal_tract_polyps0.88619715
77MP0000015_abnormal_ear_pigmentation0.85606456
78MP0003656_abnormal_erythrocyte_physiolo0.84701528
79MP0009840_abnormal_foam_cell0.83329219
80MP0003690_abnormal_glial_cell0.83238465
81MP0005275_abnormal_skin_tensile0.79121897
82MP0002019_abnormal_tumor_incidence0.79075173
83MP0001879_abnormal_lymphatic_vessel0.79002957
84MP0005075_abnormal_melanosome_morpholog0.78505845
85MP0001851_eye_inflammation0.77984769
86MP0005164_abnormal_response_to0.76919988
87MP0005167_abnormal_blood-brain_barrier0.76728785
88MP0009763_increased_sensitivity_to0.73454422
89MP0002095_abnormal_skin_pigmentation0.73303710
90MP0003091_abnormal_cell_migration0.73266469
91MP0003566_abnormal_cell_adhesion0.73144580
92MP0000920_abnormal_myelination0.72929093
93MP0004883_abnormal_blood_vessel0.72759651
94MP0008260_abnormal_autophagy0.70707548
95MP0000249_abnormal_blood_vessel0.67507453
96MP0003075_altered_response_to0.66749078
97MP0005165_increased_susceptibility_to0.66589116
98MP0003279_aneurysm0.65742487
99MP0005375_adipose_tissue_phenotype0.64995686
100MP0006054_spinal_hemorrhage0.64494420
101MP0003329_amyloid_beta_deposits0.63619066
102MP0005666_abnormal_adipose_tissue0.62908322
103MP0003646_muscle_fatigue0.62562126
104MP0001663_abnormal_digestive_system0.62277142
105MP0000767_abnormal_smooth_muscle0.62065929
106MP0005390_skeleton_phenotype0.59573975
107MP0000604_amyloidosis0.59374969
108MP0003191_abnormal_cellular_cholesterol0.58357612
109MP0005166_decreased_susceptibility_to0.58265156
110MP0002877_abnormal_melanocyte_morpholog0.57386673
111MP0002277_abnormal_respiratory_mucosa0.54916338
112MP0001958_emphysema0.54777961
113MP0003453_abnormal_keratinocyte_physiol0.54204769
114MP0003795_abnormal_bone_structure0.54036100
115MP0002163_abnormal_gland_morphology0.52722510
116MP0000313_abnormal_cell_death0.52593334
117MP0005023_abnormal_wound_healing0.52290798
118MP0000569_abnormal_digit_pigmentation0.51839452
119MP0010307_abnormal_tumor_latency0.49735203
120MP0000371_diluted_coat_color0.49713283
121MP0002136_abnormal_kidney_physiology0.48641564

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.61880041
2Recurrent bacterial skin infections (HP:0005406)5.35177093
3Eczematoid dermatitis (HP:0000976)5.27001597
4Chronic otitis media (HP:0000389)4.97796369
5Recurrent viral infections (HP:0004429)4.49374021
6Agammaglobulinemia (HP:0004432)4.47589520
7Elevated erythrocyte sedimentation rate (HP:0003565)4.42194869
8Recurrent fungal infections (HP:0002841)4.40706834
9Recurrent bronchitis (HP:0002837)4.21357665
10Cellulitis (HP:0100658)4.20555311
11Recurrent skin infections (HP:0001581)4.16769253
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.99009983
13Myositis (HP:0100614)3.87126747
14Panhypogammaglobulinemia (HP:0003139)3.83593445
15Chronic mucocutaneous candidiasis (HP:0002728)3.79834755
16Recurrent cutaneous fungal infections (HP:0011370)3.79834755
17Mediastinal lymphadenopathy (HP:0100721)3.75588106
18IgM deficiency (HP:0002850)3.72444091
19Gastrointestinal stroma tumor (HP:0100723)3.64591676
20Thrombocytosis (HP:0001894)3.64153572
21Abnormality of macrophages (HP:0004311)3.61781908
22Vasculitis (HP:0002633)3.55558593
23Meningitis (HP:0001287)3.49617830
24Inflammation of the large intestine (HP:0002037)3.35439016
25Autoimmune thrombocytopenia (HP:0001973)3.30657292
26Colitis (HP:0002583)3.29215957
27Stomatitis (HP:0010280)3.28765359
28Nasal polyposis (HP:0100582)3.26372237
29Abnormality of T cell physiology (HP:0011840)3.23887484
30Gastrointestinal inflammation (HP:0004386)3.18597162
31Abnormality of T cell number (HP:0011839)3.18041512
32Abnormality of the nasal mucosa (HP:0000433)3.16402697
33Obstructive lung disease (HP:0006536)3.14643722
34Chronic obstructive pulmonary disease (HP:0006510)3.14643722
35Abnormality of T cells (HP:0002843)3.14466351
36Recurrent gram-negative bacterial infections (HP:0005420)3.11133403
37Fatigue (HP:0012378)3.07094667
38Abnormality of liposaccharide metabolism (HP:0010968)3.05868546
39Abnormality of glycosphingolipid metabolism (HP:0004343)3.05868546
40Abnormality of glycolipid metabolism (HP:0010969)3.05868546
41Abnormality of cells of the lymphoid lineage (HP:0012140)3.04583519
42Lymphopenia (HP:0001888)3.02438264
43T lymphocytopenia (HP:0005403)2.98550075
44Spontaneous hematomas (HP:0007420)2.95032927
45Petechiae (HP:0000967)2.91334755
46Retrobulbar optic neuritis (HP:0100654)2.89298171
47Optic neuritis (HP:0100653)2.89298171
48IgG deficiency (HP:0004315)2.88367449
49Systemic lupus erythematosus (HP:0002725)2.86938871
50Emphysema (HP:0002097)2.84509993
51Increased IgE level (HP:0003212)2.80126512
52Orchitis (HP:0100796)2.78932413
53Osteomyelitis (HP:0002754)2.78371578
54Increased IgM level (HP:0003496)2.74155651
55Pulmonary infiltrates (HP:0002113)2.71809638
56Leukocytosis (HP:0001974)2.68614519
57Interstitial pulmonary disease (HP:0006530)2.67995046
58Prolonged bleeding time (HP:0003010)2.65983759
59Chronic sinusitis (HP:0011109)2.65609976
60Gingivitis (HP:0000230)2.64881988
61Hypergammaglobulinemia (HP:0010702)2.64817620
62Vacuolated lymphocytes (HP:0001922)2.60692829
63Pustule (HP:0200039)2.59138515
64Recurrent pneumonia (HP:0006532)2.57888539
65Recurrent lower respiratory tract infections (HP:0002783)2.57406455
66Hematochezia (HP:0002573)2.55895788
67Gingival bleeding (HP:0000225)2.55085466
68Recurrent sinusitis (HP:0011108)2.53367356
69Epistaxis (HP:0000421)2.50909032
70Eosinophilia (HP:0001880)2.50200291
71IgA deficiency (HP:0002720)2.48757113
72Abnormality of the peritoneum (HP:0002585)2.48695022
73Basal ganglia calcification (HP:0002135)2.47424808
74Granulocytopenia (HP:0001913)2.39853784
75Papilloma (HP:0012740)2.39794240
76Verrucae (HP:0200043)2.39794240
77Dysostosis multiplex (HP:0000943)2.39028174
78Hypertensive crisis (HP:0100735)2.37962092
79Chest pain (HP:0100749)2.36507958
80Thyroiditis (HP:0100646)2.35474536
81Arterial thrombosis (HP:0004420)2.34977441
82Loss of speech (HP:0002371)2.34847884
83Increased cerebral lipofuscin (HP:0011813)2.30045805
84Hemoptysis (HP:0002105)2.28419166
85Autoimmune hemolytic anemia (HP:0001890)2.28416643
86Abnormality of eosinophils (HP:0001879)2.27707389
87B lymphocytopenia (HP:0010976)2.26250740
88Abnormality of B cell number (HP:0010975)2.26250740
89Periodontitis (HP:0000704)2.25737341
90Arthralgia (HP:0002829)2.24897397
91Restrictive lung disease (HP:0002091)2.23312994
92Encephalitis (HP:0002383)2.22093493
93Spondylolisthesis (HP:0003302)2.21782313
94Keratoconjunctivitis sicca (HP:0001097)2.21232520
95Increased neuronal autofluorescent lipopigment (HP:0002074)2.20700109
96Skin ulcer (HP:0200042)2.20222561
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19321286
98Bronchitis (HP:0012387)2.18122587
99Severe combined immunodeficiency (HP:0004430)2.16874651
100Abnormality of the fingertips (HP:0001211)2.16500933
101Viral hepatitis (HP:0006562)2.13937492
102Sepsis (HP:0100806)2.13216731
103Acrocyanosis (HP:0001063)2.11124584
104Lymphoma (HP:0002665)2.08208312
105Peritonitis (HP:0002586)2.07554667
106Urticaria (HP:0001025)2.06176521
107Dilatation of the ascending aorta (HP:0005111)2.04518356
108Chronic diarrhea (HP:0002028)2.02515657
109Abnormality of the prostate (HP:0008775)2.02263431
110Abnormality of the pleura (HP:0002103)2.00830700
111Thoracolumbar scoliosis (HP:0002944)1.98474719
112Gastrointestinal infarctions (HP:0005244)1.98270732
113Axonal loss (HP:0003447)1.98114169
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.98048117
115Osteolytic defects of the hand bones (HP:0009699)1.98048117
116Amaurosis fugax (HP:0100576)1.97378238
117Aortic aneurysm (HP:0004942)1.95420805
118Thin bony cortex (HP:0002753)1.95191172
119Keratoconjunctivitis (HP:0001096)1.94858275
120Protrusio acetabuli (HP:0003179)1.92307758
121Purpura (HP:0000979)1.80482429
122Pulmonary embolism (HP:0002204)1.80020858
123Glomerulopathy (HP:0100820)1.79716078
124Increased variability in muscle fiber diameter (HP:0003557)1.77957723
125Skin rash (HP:0000988)1.77804976

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.75265236
2PRPF4B3.95253711
3MAP3K143.17770981
4TYK22.89314256
5JAK32.88707435
6TBK12.85323461
7BLK2.69188764
8KIT2.49683481
9IKBKB2.44882226
10IRAK42.39151923
11TXK2.30561513
12RIPK42.26592496
13IKBKE2.21492316
14NME22.21132434
15ZAP702.10595551
16EPHB12.06868439
17SYK1.99863424
18MAP3K131.97021394
19BTK1.97013134
20CSF1R1.90506964
21JAK11.89314440
22DDR21.82836240
23TEC1.72268904
24IRAK31.70541551
25TAOK21.64641111
26CDC42BPA1.63076480
27PIM21.60458353
28LRRK21.52911159
29LCK1.47494537
30MAP3K101.46009910
31NLK1.44054473
32STK101.40817901
33KDR1.40458159
34CHUK1.37464600
35GRK61.30397685
36HCK1.30041158
37TGFBR21.29373591
38MOS1.22481935
39PIM11.21775610
40CSK1.16501728
41TESK21.15908319
42LYN1.15562455
43SMG11.15488485
44BMPR21.14628282
45EEF2K1.14216998
46EPHA31.13268263
47ERN11.09813655
48RIPK11.07638232
49ITK1.07157194
50FES1.06734868
51FGFR41.05582524
52MAPK71.04584880
53ARAF1.03330050
54MAP2K30.99530595
55TGFBR10.99259160
56TTN0.98047133
57PDGFRA0.97387335
58JAK20.93911770
59STK40.93615337
60MAPKAPK50.89073054
61RPS6KA40.88782383
62CLK10.87736199
63MAPK120.86620764
64TRIB30.85835125
65PBK0.85749299
66PIK3CG0.83030554
67MAPK110.82378683
68SCYL20.80358324
69TAOK30.76170751
70PRKCQ0.73736780
71MST40.73331058
72MATK0.70164232
73HIPK20.69483058
74TRPM70.66244269
75FLT30.66037534
76MAP3K30.65542543
77CDK120.65467563
78CAMKK10.65414468
79PRKCH0.64480395
80TIE10.63349672
81IRAK10.63069895
82RPS6KA50.62161657
83SIK20.61923231
84FGFR30.61308872
85MUSK0.59715714
86NEK90.58064426
87MAPKAPK20.55952312
88MARK20.54536518
89MAP3K50.54398179
90PKN10.53094068
91RPS6KA20.52562704
92PKN20.51850850
93SIK10.51766836
94CAMKK20.51434208
95RPS6KC10.50794273
96RPS6KL10.50794273
97MAP3K110.50775650
98ABL10.50370128
99PDPK10.49814546
100MARK30.48893160
101DAPK30.48644824
102PRKCD0.47776013
103TAOK10.46581780
104ICK0.45855140
105EIF2AK30.44795557
106ILK0.44308453
107MYLK0.43565761
108STK240.42455976
109PRKD20.41769166
110PTK60.41700885
111ACVR1B0.38661905
112FGR0.37812672
113KSR20.37738901
114RPS6KA60.37679559
115EGFR0.36833084
116PRKD10.36457252
117TESK10.35167751
118CDK40.34484702
119INSR0.34282080
120GRK70.34169081
121TYRO30.33753707
122MELK0.33557429
123ALK0.33430628
124MAP3K120.32019260
125FYN0.31354436
126SIK30.31243528
127TNK20.29803543
128MAP3K10.29002507
129PDK10.28608552
130MAPK40.28118023
131DMPK0.26465012
132TLK10.26044205
133MAP3K80.24899681
134YES10.23970788

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.57687999
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.95332398
3Leishmaniasis_Homo sapiens_hsa051402.90206760
4B cell receptor signaling pathway_Homo sapiens_hsa046622.79860329
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.72033462
6Allograft rejection_Homo sapiens_hsa053302.71002189
7Measles_Homo sapiens_hsa051622.44745214
8Osteoclast differentiation_Homo sapiens_hsa043802.40300578
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36257347
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28173423
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.13160813
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09832980
13Graft-versus-host disease_Homo sapiens_hsa053322.06970453
14Antigen processing and presentation_Homo sapiens_hsa046122.03603517
15Hematopoietic cell lineage_Homo sapiens_hsa046402.01801002
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.99907775
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.78712427
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.77935058
19Asthma_Homo sapiens_hsa053101.73274331
20Toxoplasmosis_Homo sapiens_hsa051451.69587787
21Herpes simplex infection_Homo sapiens_hsa051681.69422720
22T cell receptor signaling pathway_Homo sapiens_hsa046601.67365549
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62366077
24Malaria_Homo sapiens_hsa051441.60784492
25Pertussis_Homo sapiens_hsa051331.59903115
26Tuberculosis_Homo sapiens_hsa051521.58678530
27Autoimmune thyroid disease_Homo sapiens_hsa053201.57820468
28Chemokine signaling pathway_Homo sapiens_hsa040621.57211309
29Shigellosis_Homo sapiens_hsa051311.55785665
30TNF signaling pathway_Homo sapiens_hsa046681.52450601
31Influenza A_Homo sapiens_hsa051641.52436711
32Ribosome_Homo sapiens_hsa030101.49275077
33Legionellosis_Homo sapiens_hsa051341.49256624
34Apoptosis_Homo sapiens_hsa042101.46683102
35Viral myocarditis_Homo sapiens_hsa054161.42111995
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42078466
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38186290
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35136610
39Acute myeloid leukemia_Homo sapiens_hsa052211.33551318
40Salmonella infection_Homo sapiens_hsa051321.23522013
41Hepatitis B_Homo sapiens_hsa051611.20213677
42Platelet activation_Homo sapiens_hsa046111.14609754
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.13668495
44DNA replication_Homo sapiens_hsa030301.13467862
45Rheumatoid arthritis_Homo sapiens_hsa053231.07646482
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02338856
47Chronic myeloid leukemia_Homo sapiens_hsa052201.00599720
48Staphylococcus aureus infection_Homo sapiens_hsa051500.99403627
49Type I diabetes mellitus_Homo sapiens_hsa049400.96147586
50Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96121780
51Epstein-Barr virus infection_Homo sapiens_hsa051690.95923239
52African trypanosomiasis_Homo sapiens_hsa051430.93359612
53Lysosome_Homo sapiens_hsa041420.92783563
54Pancreatic cancer_Homo sapiens_hsa052120.87111807
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86634226
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86349208
57Other glycan degradation_Homo sapiens_hsa005110.85447088
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82676221
59Hepatitis C_Homo sapiens_hsa051600.81389255
60Base excision repair_Homo sapiens_hsa034100.80724566
61Viral carcinogenesis_Homo sapiens_hsa052030.78253688
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75852411
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.71718911
64Small cell lung cancer_Homo sapiens_hsa052220.71030102
65HTLV-I infection_Homo sapiens_hsa051660.70810960
66Prolactin signaling pathway_Homo sapiens_hsa049170.70248755
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65004956
68Phagosome_Homo sapiens_hsa041450.63412096
69Prion diseases_Homo sapiens_hsa050200.61665443
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.57624712
71VEGF signaling pathway_Homo sapiens_hsa043700.56673769
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.56329032
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51394421
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50568662
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49300895
76Bladder cancer_Homo sapiens_hsa052190.48300515
77p53 signaling pathway_Homo sapiens_hsa041150.47373658
78Mismatch repair_Homo sapiens_hsa034300.46695293
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.46575986
80Endocytosis_Homo sapiens_hsa041440.45301809
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43471212
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42668104
83GnRH signaling pathway_Homo sapiens_hsa049120.42160662
84Type II diabetes mellitus_Homo sapiens_hsa049300.40794342
85Non-small cell lung cancer_Homo sapiens_hsa052230.40017370
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.39569878
87Focal adhesion_Homo sapiens_hsa045100.38589887
88Homologous recombination_Homo sapiens_hsa034400.36793509
89HIF-1 signaling pathway_Homo sapiens_hsa040660.36446917
90Non-homologous end-joining_Homo sapiens_hsa034500.34409034
91Amoebiasis_Homo sapiens_hsa051460.32395235
92Proteasome_Homo sapiens_hsa030500.31505080
93MicroRNAs in cancer_Homo sapiens_hsa052060.31440544
94MAPK signaling pathway_Homo sapiens_hsa040100.30191514
95Prostate cancer_Homo sapiens_hsa052150.29916673
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29666984
97Notch signaling pathway_Homo sapiens_hsa043300.29500251
98Renal cell carcinoma_Homo sapiens_hsa052110.28892291
99Pathways in cancer_Homo sapiens_hsa052000.27027506
100Systemic lupus erythematosus_Homo sapiens_hsa053220.26502185
101Glioma_Homo sapiens_hsa052140.26224717
102Colorectal cancer_Homo sapiens_hsa052100.26200856
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26114367
104mTOR signaling pathway_Homo sapiens_hsa041500.24931599
105Insulin resistance_Homo sapiens_hsa049310.22899692
106FoxO signaling pathway_Homo sapiens_hsa040680.22486409
107Spliceosome_Homo sapiens_hsa030400.21276976
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.21217959
109Endometrial cancer_Homo sapiens_hsa052130.20761860
110ErbB signaling pathway_Homo sapiens_hsa040120.20727789
111Inositol phosphate metabolism_Homo sapiens_hsa005620.20224560
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20039729
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18511120
114RNA degradation_Homo sapiens_hsa030180.18247793
115Estrogen signaling pathway_Homo sapiens_hsa049150.18145390
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17651929
117Dorso-ventral axis formation_Homo sapiens_hsa043200.17344295
118Proteoglycans in cancer_Homo sapiens_hsa052050.15642139

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