ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	4.90061337
2	behavioral response to nicotine (GO:0035095)	4.24099921
3	organic cation transport (GO:0015695)	4.17020572
4	indole-containing compound catabolic process (GO:0042436)	3.97196768
5	indolalkylamine catabolic process (GO:0046218)	3.97196768
6	tryptophan catabolic process (GO:0006569)	3.97196768
7	L-fucose catabolic process (GO:0042355)	3.96781378
8	fucose catabolic process (GO:0019317)	3.96781378
9	L-fucose metabolic process (GO:0042354)	3.96781378
10	respiratory chain complex IV assembly (GO:0008535)	3.88118804
11	detection of light stimulus involved in visual perception (GO:0050908)	3.69527803
12	detection of light stimulus involved in sensory perception (GO:0050962)	3.69527803
13	DNA deamination (GO:0045006)	3.68346866
14	kynurenine metabolic process (GO:0070189)	3.64381769
15	indolalkylamine metabolic process (GO:0006586)	3.62194514
16	protein complex biogenesis (GO:0070271)	3.60784367
17	cytochrome complex assembly (GO:0017004)	3.60307656
18	acrosome reaction (GO:0007340)	3.48877967
19	protein K11-linked deubiquitination (GO:0035871)	3.46889239
20	NADH dehydrogenase complex assembly (GO:0010257)	3.44683918
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.44683918
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.44683918
23	multicellular organism reproduction (GO:0032504)	3.43239536
24	nucleotide transmembrane transport (GO:1901679)	3.33314879
25	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.31947855
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.31110807
27	tryptophan metabolic process (GO:0006568)	3.28533840
28	mitochondrial respiratory chain complex assembly (GO:0033108)	3.27471742
29	piRNA metabolic process (GO:0034587)	3.25993903
30	behavioral response to ethanol (GO:0048149)	3.24249220
31	water-soluble vitamin biosynthetic process (GO:0042364)	3.19623209
32	positive regulation of prostaglandin secretion (GO:0032308)	3.14320061
33	protein-cofactor linkage (GO:0018065)	3.12183765
34	epithelial cilium movement (GO:0003351)	3.10328413
35	negative regulation of mast cell activation (GO:0033004)	3.09370768
36	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.07861233
37	mannosylation (GO:0097502)	3.04014207
38	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.01926040
39	cornea development in camera-type eye (GO:0061303)	3.01634392
40	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.99457711
41	axoneme assembly (GO:0035082)	2.97421800
42	neural tube formation (GO:0001841)	2.95221749
43	inositol phosphate catabolic process (GO:0071545)	2.93751819
44	GPI anchor metabolic process (GO:0006505)	2.93458100
45	amino acid salvage (GO:0043102)	2.93373219
46	L-methionine salvage (GO:0071267)	2.93373219
47	L-methionine biosynthetic process (GO:0071265)	2.93373219
48	positive regulation of fatty acid transport (GO:2000193)	2.92954148
49	adaptation of signaling pathway (GO:0023058)	2.92829273
50	amine catabolic process (GO:0009310)	2.92042918
51	cellular biogenic amine catabolic process (GO:0042402)	2.92042918
52	alanine transport (GO:0032328)	2.91944437
53	sperm motility (GO:0030317)	2.88041913
54	cellular ketone body metabolic process (GO:0046950)	2.87288847
55	DNA methylation involved in gamete generation (GO:0043046)	2.86888281
56	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.85179509
57	regulation of meiosis I (GO:0060631)	2.85110956
58	platelet dense granule organization (GO:0060155)	2.84656318
59	ATP synthesis coupled proton transport (GO:0015986)	2.79388793
60	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.79388793
61	photoreceptor cell maintenance (GO:0045494)	2.78098040
62	C4-dicarboxylate transport (GO:0015740)	2.77921236
63	negative regulation of telomere maintenance (GO:0032205)	2.77805951
64	protein K6-linked ubiquitination (GO:0085020)	2.74749471
65	synapsis (GO:0007129)	2.74370815
66	reflex (GO:0060004)	2.72999022
67	male meiosis (GO:0007140)	2.70578359
68	gamma-aminobutyric acid transport (GO:0015812)	2.70415384
69	negative regulation of multicellular organism growth (GO:0040015)	2.69385730
70	meiotic chromosome segregation (GO:0045132)	2.67374256
71	male meiosis I (GO:0007141)	2.64759699
72	ketone body metabolic process (GO:1902224)	2.63341959
73	positive regulation of icosanoid secretion (GO:0032305)	2.62982916
74	nucleoside transmembrane transport (GO:1901642)	2.62640166
75	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.61982175
76	C-terminal protein lipidation (GO:0006501)	2.60863564
77	pseudouridine synthesis (GO:0001522)	2.60297851
78	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.59879569
79	heme transport (GO:0015886)	2.57367186
80	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.56473943
81	C-terminal protein amino acid modification (GO:0018410)	2.55860751
82	phosphatidylcholine acyl-chain remodeling (GO:0036151)	2.54329140
83	ubiquinone biosynthetic process (GO:0006744)	2.54082998
84	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52309377
85	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.51765065
86	polyol catabolic process (GO:0046174)	2.51493354
87	cilium movement (GO:0003341)	2.50346420
88	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.50174428
89	estrogen biosynthetic process (GO:0006703)	2.49822140
90	regulation of cilium movement (GO:0003352)	2.49401282
91	chaperone-mediated protein transport (GO:0072321)	2.48385680
92	righting reflex (GO:0060013)	2.48163936
93	protein localization to cilium (GO:0061512)	2.47980940
94	cilium morphogenesis (GO:0060271)	2.47354109
95	sulfation (GO:0051923)	2.47062045
96	indole-containing compound metabolic process (GO:0042430)	2.46972250
97	GPI anchor biosynthetic process (GO:0006506)	2.46330742
98	methionine biosynthetic process (GO:0009086)	2.45502342
99	auditory receptor cell stereocilium organization (GO:0060088)	2.45044075
100	proline transport (GO:0015824)	2.44206926

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.75200068
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.33214499
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.19840078
4	VDR_22108803_ChIP-Seq_LS180_Human	2.98740073
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74346418
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.53067246
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41857241
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40018026
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.22455586
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.20497983
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19515004
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.16123327
13	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.12007233
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11453597
15	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.00537962
16	FUS_26573619_Chip-Seq_HEK293_Human	2.00529800
17	P300_19829295_ChIP-Seq_ESCs_Human	1.98722636
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.96230743
19	ER_23166858_ChIP-Seq_MCF-7_Human	1.95766947
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.88362506
21	EWS_26573619_Chip-Seq_HEK293_Human	1.84759460
22	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.71278363
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.67948311
24	CBP_20019798_ChIP-Seq_JUKART_Human	1.67948311
25	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.65041754
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.64407933
27	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62800172
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.61584327
29	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.61563425
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.56937173
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54866923
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.51075667
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.50621423
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.50320766
35	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.50279761
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.48230449
37	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46633523
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.46531255
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.46531255
40	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45409307
41	AR_25329375_ChIP-Seq_VCAP_Human	1.45224926
42	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42474762
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39442439
44	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.37021850
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36551802
46	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36551802
47	TCF4_23295773_ChIP-Seq_U87_Human	1.35350135
48	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.35233677
49	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.34828644
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.33314304
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.33296453
52	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.33040149
53	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.31898720
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31250456
55	STAT3_23295773_ChIP-Seq_U87_Human	1.29481166
56	NCOR_22424771_ChIP-Seq_293T_Human	1.29304116
57	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28104429
58	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28104429
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27922874
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.27730345
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.27457888
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25307422
63	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.24412629
64	AR_20517297_ChIP-Seq_VCAP_Human	1.24384449
65	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23410537
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22869112
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.22221396
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.20160858
69	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19713609
70	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.19685298
71	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19523558
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.18817931
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18247884
74	MYC_18940864_ChIP-ChIP_HL60_Human	1.18189882
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18078866
76	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.17855767
77	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.15740032
78	CDX2_22108803_ChIP-Seq_LS180_Human	1.14230796
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13850341
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11502661
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11189466
82	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.10286998
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.09712258
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09203411
85	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08121622
86	VDR_23849224_ChIP-Seq_CD4+_Human	1.07304291
87	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07224748
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06898668
89	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.06336967
90	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05625469
91	ELK1_19687146_ChIP-ChIP_HELA_Human	1.05559321
92	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05241185
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05194949
94	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04792789
95	AR_21572438_ChIP-Seq_LNCaP_Human	1.03954187
96	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03738913
97	ETV1_20927104_ChIP-Seq_GIST48_Human	1.03592572
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.01200854
99	PHF8_20622853_ChIP-Seq_HELA_Human	1.00502877
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.99506047

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005551_abnormal_eye_electrophysiolog	2.82082101
2	MP0006072_abnormal_retinal_apoptosis	2.74667416
3	MP0002876_abnormal_thyroid_physiology	2.73789641
4	MP0001968_abnormal_touch/_nociception	2.71214612
5	MP0002138_abnormal_hepatobiliary_system	2.66868585
6	MP0002837_dystrophic_cardiac_calcinosis	2.64275540
7	MP0003195_calcinosis	2.46995501
8	MP0008877_abnormal_DNA_methylation	2.46596403
9	MP0005410_abnormal_fertilization	2.32377542
10	MP0000372_irregular_coat_pigmentation	2.19217914
11	MP0002102_abnormal_ear_morphology	2.18611308
12	MP0005253_abnormal_eye_physiology	2.12951964
13	MP0003011_delayed_dark_adaptation	2.06375997
14	MP0002736_abnormal_nociception_after	2.04675060
15	MP0008872_abnormal_physiological_respon	2.02063036
16	MP0008875_abnormal_xenobiotic_pharmacok	1.98195430
17	MP0002653_abnormal_ependyma_morphology	1.97818595
18	MP0003646_muscle_fatigue	1.97014162
19	MP0003880_abnormal_central_pattern	1.96507442
20	MP0003136_yellow_coat_color	1.94464914
21	MP0009745_abnormal_behavioral_response	1.83898784
22	MP0005646_abnormal_pituitary_gland	1.82906412
23	MP0003718_maternal_effect	1.77314030
24	MP0006276_abnormal_autonomic_nervous	1.73290954
25	MP0002638_abnormal_pupillary_reflex	1.63993964
26	MP0009046_muscle_twitch	1.63753260
27	MP0001984_abnormal_olfaction	1.57634721
28	MP0004885_abnormal_endolymph	1.57460506
29	MP0004145_abnormal_muscle_electrophysio	1.56880875
30	MP0010386_abnormal_urinary_bladder	1.56157372
31	MP0002272_abnormal_nervous_system	1.55611828
32	MP0005084_abnormal_gallbladder_morpholo	1.55399226
33	MP0001501_abnormal_sleep_pattern	1.52344444
34	MP0002160_abnormal_reproductive_system	1.49687020
35	MP0004142_abnormal_muscle_tone	1.48109357
36	MP0005645_abnormal_hypothalamus_physiol	1.47829505
37	MP0001485_abnormal_pinna_reflex	1.42450499
38	MP0001986_abnormal_taste_sensitivity	1.41321684
39	MP0005389_reproductive_system_phenotype	1.39740120
40	MP0001486_abnormal_startle_reflex	1.34764209
41	MP0004782_abnormal_surfactant_physiolog	1.29678984
42	MP0004742_abnormal_vestibular_system	1.29389797
43	MP0001970_abnormal_pain_threshold	1.28055611
44	MP0005360_urolithiasis	1.27847139
45	MP0002938_white_spotting	1.27180957
46	MP0002234_abnormal_pharynx_morphology	1.25315831
47	MP0000427_abnormal_hair_cycle	1.22130357
48	MP0003787_abnormal_imprinting	1.19681398
49	MP0004147_increased_porphyrin_level	1.19169646
50	MP0006036_abnormal_mitochondrial_physio	1.18710241
51	MP0005379_endocrine/exocrine_gland_phen	1.17071207
52	MP0001905_abnormal_dopamine_level	1.16441447
53	MP0002733_abnormal_thermal_nociception	1.15298429
54	MP0004043_abnormal_pH_regulation	1.14340689
55	MP0000631_abnormal_neuroendocrine_gland	1.14281122
56	MP0000538_abnormal_urinary_bladder	1.13677984
57	MP0005085_abnormal_gallbladder_physiolo	1.11877630
58	MP0003698_abnormal_male_reproductive	1.11621285
59	MP0005332_abnormal_amino_acid	1.09864087
60	MP0000383_abnormal_hair_follicle	1.09747508
61	MP0002735_abnormal_chemical_nociception	1.09344459
62	MP0002751_abnormal_autonomic_nervous	1.09209515
63	MP0001919_abnormal_reproductive_system	1.08098565
64	MP0001529_abnormal_vocalization	1.07966778
65	MP0004133_heterotaxia	1.06745749
66	MP0002095_abnormal_skin_pigmentation	1.06130861
67	MP0002064_seizures	1.05831784
68	MP0005365_abnormal_bile_salt	1.05762782
69	MP0001929_abnormal_gametogenesis	1.04988853
70	MP0008775_abnormal_heart_ventricle	1.03081559
71	MP0005174_abnormal_tail_pigmentation	1.02210289
72	MP0002163_abnormal_gland_morphology	1.02202420
73	MP0003137_abnormal_impulse_conducting	0.98953989
74	MP0002572_abnormal_emotion/affect_behav	0.98587807
75	MP0003252_abnormal_bile_duct	0.97732457
76	MP0002928_abnormal_bile_duct	0.97410369
77	MP0002693_abnormal_pancreas_physiology	0.97245425
78	MP0002734_abnormal_mechanical_nocicepti	0.96583996
79	MP0002557_abnormal_social/conspecific_i	0.91073495
80	MP0005195_abnormal_posterior_eye	0.90556915
81	MP0002229_neurodegeneration	0.90508009
82	MP0005171_absent_coat_pigmentation	0.88808626
83	MP0001177_atelectasis	0.87630259
84	MP0002254_reproductive_system_inflammat	0.87205442
85	MP0002067_abnormal_sensory_capabilities	0.85751535
86	MP0000230_abnormal_systemic_arterial	0.84662775
87	MP0001764_abnormal_homeostasis	0.84616591
88	MP0002210_abnormal_sex_determination	0.83792913
89	MP0002752_abnormal_somatic_nervous	0.83785352
90	MP0005075_abnormal_melanosome_morpholog	0.82154377
91	MP0005394_taste/olfaction_phenotype	0.81894599
92	MP0005499_abnormal_olfactory_system	0.81894599
93	MP0008789_abnormal_olfactory_epithelium	0.81236004
94	MP0006292_abnormal_olfactory_placode	0.80895896
95	MP0000569_abnormal_digit_pigmentation	0.80666601
96	MP0002132_abnormal_respiratory_system	0.80445031
97	MP0009764_decreased_sensitivity_to	0.80116947
98	MP0001944_abnormal_pancreas_morphology	0.79928490
99	MP0001756_abnormal_urination	0.79396888
100	MP0003890_abnormal_embryonic-extraembry	0.79238492

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.31296934
2	Abnormality of midbrain morphology (HP:0002418)	4.19848308
3	Molar tooth sign on MRI (HP:0002419)	4.19848308
4	Pancreatic cysts (HP:0001737)	3.83657550
5	Pancreatic fibrosis (HP:0100732)	3.59956167
6	Abnormal rod and cone electroretinograms (HP:0008323)	3.58311032
7	Thyroiditis (HP:0100646)	3.42895312
8	True hermaphroditism (HP:0010459)	3.31511748
9	Type II lissencephaly (HP:0007260)	3.28404563
10	Abnormality of the renal cortex (HP:0011035)	3.15988090
11	Nephronophthisis (HP:0000090)	3.11996907
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.10368983
13	Chronic hepatic failure (HP:0100626)	3.09028015
14	Acute necrotizing encephalopathy (HP:0006965)	3.01130127
15	Abolished electroretinogram (ERG) (HP:0000550)	2.88468317
16	Attenuation of retinal blood vessels (HP:0007843)	2.86805754
17	Retinal dysplasia (HP:0007973)	2.82812070
18	Severe combined immunodeficiency (HP:0004430)	2.76058920
19	Progressive macrocephaly (HP:0004481)	2.73940609
20	Mitochondrial inheritance (HP:0001427)	2.72459291
21	Hypoproteinemia (HP:0003075)	2.70571483
22	3-Methylglutaconic aciduria (HP:0003535)	2.70485654
23	Renal cortical cysts (HP:0000803)	2.70458847
24	Abnormality of macular pigmentation (HP:0008002)	2.69574299
25	Abnormality of the renal medulla (HP:0100957)	2.68744699
26	Pendular nystagmus (HP:0012043)	2.67485544
27	Abnormality of B cell number (HP:0010975)	2.61247269
28	Acute encephalopathy (HP:0006846)	2.57883838
29	Increased CSF lactate (HP:0002490)	2.56143354
30	Inability to walk (HP:0002540)	2.46222514
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.46014461
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.43657547
33	Hypoplasia of the fovea (HP:0007750)	2.43657547
34	Cerebellar dysplasia (HP:0007033)	2.41142124
35	Polydipsia (HP:0001959)	2.39994603
36	Abnormal drinking behavior (HP:0030082)	2.39994603
37	B lymphocytopenia (HP:0010976)	2.37092957
38	Congenital sensorineural hearing impairment (HP:0008527)	2.36583801
39	Medial flaring of the eyebrow (HP:0010747)	2.35816394
40	Severe visual impairment (HP:0001141)	2.34240146
41	Hyperventilation (HP:0002883)	2.33968057
42	Hypothermia (HP:0002045)	2.33791304
43	Decreased circulating renin level (HP:0003351)	2.30419252
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.30303156
45	Colon cancer (HP:0003003)	2.29197022
46	Amelogenesis imperfecta (HP:0000705)	2.28152705
47	Lipid accumulation in hepatocytes (HP:0006561)	2.26308420
48	Decreased central vision (HP:0007663)	2.25461335
49	Large for gestational age (HP:0001520)	2.23593331
50	Keratoconus (HP:0000563)	2.19311315
51	Increased corneal curvature (HP:0100692)	2.19311315
52	Progressive inability to walk (HP:0002505)	2.19037666
53	Optic disc pallor (HP:0000543)	2.19015686
54	Hepatocellular necrosis (HP:0001404)	2.18623241
55	Cystic liver disease (HP:0006706)	2.17367768
56	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16612473
57	Absent speech (HP:0001344)	2.15731978
58	Tubular atrophy (HP:0000092)	2.15258127
59	Stomach cancer (HP:0012126)	2.14718039
60	Constricted visual fields (HP:0001133)	2.14583418
61	Hemiparesis (HP:0001269)	2.12105680
62	Polyuria (HP:0000103)	2.12026254
63	Bony spicule pigmentary retinopathy (HP:0007737)	2.11788116
64	Pachygyria (HP:0001302)	2.11666514
65	Hepatic necrosis (HP:0002605)	2.10670002
66	Abnormality of eosinophils (HP:0001879)	2.09883292
67	Abnormality of the labia minora (HP:0012880)	2.08301046
68	Abnormality of the fovea (HP:0000493)	2.07568268
69	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.04978599
70	Absent/shortened dynein arms (HP:0200106)	2.04978599
71	Focal motor seizures (HP:0011153)	2.03836375
72	Methylmalonic acidemia (HP:0002912)	2.03016471
73	Sclerocornea (HP:0000647)	2.00088178
74	Abnormality of dental color (HP:0011073)	1.98185900
75	Gaze-evoked nystagmus (HP:0000640)	1.97743897
76	Focal seizures (HP:0007359)	1.95902232
77	Lissencephaly (HP:0001339)	1.93065690
78	Stomatitis (HP:0010280)	1.92981191
79	Congenital, generalized hypertrichosis (HP:0004540)	1.92965395
80	Albinism (HP:0001022)	1.92392337
81	Congenital hepatic fibrosis (HP:0002612)	1.92387718
82	Methylmalonic aciduria (HP:0012120)	1.91377740
83	Dialeptic seizures (HP:0011146)	1.91333219
84	Increased hepatocellular lipid droplets (HP:0006565)	1.90316714
85	Combined immunodeficiency (HP:0005387)	1.87904634
86	Abnormal biliary tract physiology (HP:0012439)	1.86313695
87	Bile duct proliferation (HP:0001408)	1.86313695
88	Anencephaly (HP:0002323)	1.85780010
89	Occipital encephalocele (HP:0002085)	1.84523544
90	Short tibia (HP:0005736)	1.83299754
91	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82936364
92	Furrowed tongue (HP:0000221)	1.82619189
93	IgG deficiency (HP:0004315)	1.81482702
94	Increased serum lactate (HP:0002151)	1.81209395
95	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.75550876
96	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.75550876
97	Hypoplasia of the thymus (HP:0000778)	1.74993314
98	Optic nerve hypoplasia (HP:0000609)	1.74795781
99	Retinitis pigmentosa (HP:0000510)	1.74452941
100	Male pseudohermaphroditism (HP:0000037)	1.73724673

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.00559665
2	BMPR1B	4.06369458
3	PINK1	3.09485799
4	ADRBK2	2.93295186
5	INSRR	2.80826001
6	WNK3	2.63196850
7	NUAK1	2.24145463
8	VRK2	2.01447990
9	TXK	2.00070617
10	GRK1	1.96905632
11	ZAK	1.89645252
12	TLK1	1.89474900
13	MAP4K2	1.68542134
14	CASK	1.66766524
15	STK16	1.65487723
16	MAPK13	1.62725742
17	TRIM28	1.59980241
18	EIF2AK3	1.49745024
19	MAP3K4	1.46725398
20	VRK1	1.46072380
21	MUSK	1.44501476
22	FGFR2	1.42305480
23	CDK8	1.40632983
24	TGFBR1	1.39457039
25	PAK3	1.35942425
26	WNK4	1.32175292
27	ACVR1B	1.26997098
28	DAPK2	1.25831198
29	MAPKAPK3	1.25514279
30	MST4	1.20248279
31	OXSR1	1.19366449
32	STK38L	1.18409715
33	MKNK2	1.11056583
34	TAOK3	1.10941867
35	STK39	1.10329689
36	PLK2	1.04049847
37	MAP2K7	0.98551202
38	PIK3CA	0.96030484
39	TAF1	0.93501337
40	CSNK1G1	0.93239018
41	DYRK2	0.93042628
42	PRKCE	0.92524643
43	CSNK1G2	0.90128170
44	CSNK1G3	0.89129059
45	ERBB3	0.89115438
46	ADRBK1	0.88950603
47	PLK3	0.76856314
48	MARK3	0.76517436
49	CAMKK2	0.75504499
50	TEC	0.75134615
51	CSNK1A1L	0.73548952
52	STK38	0.72431311
53	BCKDK	0.69675349
54	NTRK3	0.69543637
55	PRKCG	0.68872806
56	NLK	0.68315538
57	PTK2B	0.67137102
58	PIK3CG	0.66657260
59	MAPKAPK5	0.66239513
60	MARK1	0.64968967
61	KIT	0.64273419
62	TNIK	0.63700225
63	CAMK2A	0.60001669
64	RPS6KA5	0.59951402
65	TIE1	0.58820851
66	STK3	0.58802561
67	CSNK1A1	0.55833571
68	PHKG2	0.55204026
69	PHKG1	0.55204026
70	CDK9	0.54763813
71	IKBKB	0.53575348
72	STK11	0.52298066
73	BCR	0.52131747
74	PRKCQ	0.52025695
75	PKN1	0.50770042
76	LATS1	0.48862247
77	TNK2	0.48137436
78	EIF2AK1	0.45831728
79	PLK4	0.45136021
80	PRKACA	0.44961377
81	PRKCZ	0.44899617
82	MAP2K2	0.44351039
83	DAPK1	0.44158001
84	CDK3	0.43133417
85	FER	0.43116432
86	MAP2K6	0.42146195
87	GRK5	0.41802824
88	TRPM7	0.39614789
89	PRKCI	0.39084988
90	EIF2AK2	0.37526874
91	SYK	0.36529726
92	OBSCN	0.36519738
93	NME1	0.36064785
94	CSNK1D	0.35765880
95	PRKCA	0.34012027
96	ITK	0.33679569
97	MKNK1	0.33326454
98	CDC7	0.32098477
99	CAMK2D	0.31924985
100	GRK7	0.31410538

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.73627028
2	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.68259026
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.66913174
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59843743
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.58363159
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.53443222
7	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.47742492
8	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.29202961
9	Ether lipid metabolism_Homo sapiens_hsa00565	2.19771499
10	One carbon pool by folate_Homo sapiens_hsa00670	2.03135535
11	Caffeine metabolism_Homo sapiens_hsa00232	2.02598297
12	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.01643231
13	Butanoate metabolism_Homo sapiens_hsa00650	1.94300826
14	Protein export_Homo sapiens_hsa03060	1.94244235
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.94088871
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.88952069
17	Selenocompound metabolism_Homo sapiens_hsa00450	1.87630501
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.84273858
19	RNA polymerase_Homo sapiens_hsa03020	1.83162988
20	Parkinsons disease_Homo sapiens_hsa05012	1.76675161
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.74283721
22	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.70616973
23	Homologous recombination_Homo sapiens_hsa03440	1.62997628
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.62550587
25	Nicotine addiction_Homo sapiens_hsa05033	1.38912094
26	Collecting duct acid secretion_Homo sapiens_hsa04966	1.37244153
27	Propanoate metabolism_Homo sapiens_hsa00640	1.35077623
28	Primary immunodeficiency_Homo sapiens_hsa05340	1.33433218
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.32945184
30	Peroxisome_Homo sapiens_hsa04146	1.24102663
31	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.21105505
32	Taste transduction_Homo sapiens_hsa04742	1.19883673
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.18586013
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.18266930
35	Olfactory transduction_Homo sapiens_hsa04740	1.17997955
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.16044507
37	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.14001554
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.13503948
39	Basal transcription factors_Homo sapiens_hsa03022	1.11699570
40	Huntingtons disease_Homo sapiens_hsa05016	1.07716950
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07503902
42	Alzheimers disease_Homo sapiens_hsa05010	1.07423587
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.05361299
44	Proteasome_Homo sapiens_hsa03050	1.04180466
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03755712
46	Non-homologous end-joining_Homo sapiens_hsa03450	1.03062689
47	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.02779097
48	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.02003762
49	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.01361592
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95239823
51	Morphine addiction_Homo sapiens_hsa05032	0.94645606
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94102723
53	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93262984
54	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.93012960
55	Folate biosynthesis_Homo sapiens_hsa00790	0.92956042
56	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.90424687
57	Retinol metabolism_Homo sapiens_hsa00830	0.90268136
58	Sulfur metabolism_Homo sapiens_hsa00920	0.88475737
59	RNA degradation_Homo sapiens_hsa03018	0.87624608
60	Mineral absorption_Homo sapiens_hsa04978	0.86593308
61	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86201166
62	Purine metabolism_Homo sapiens_hsa00230	0.84445959
63	Steroid biosynthesis_Homo sapiens_hsa00100	0.83772598
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.83010579
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.79827520
66	Metabolic pathways_Homo sapiens_hsa01100	0.77772829
67	GABAergic synapse_Homo sapiens_hsa04727	0.76775187
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.73110679
69	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70667959
70	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.69599807
71	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68983849
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68262776
73	Regulation of autophagy_Homo sapiens_hsa04140	0.66719628
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.64214718
75	Fatty acid degradation_Homo sapiens_hsa00071	0.63625654
76	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.63194716
77	Fatty acid elongation_Homo sapiens_hsa00062	0.61972863
78	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61681053
79	Insulin secretion_Homo sapiens_hsa04911	0.60946381
80	Serotonergic synapse_Homo sapiens_hsa04726	0.60286185
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53806073
82	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.52394649
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.50880394
84	Sulfur relay system_Homo sapiens_hsa04122	0.50473676
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.50003202
86	Glutamatergic synapse_Homo sapiens_hsa04724	0.49723381
87	ABC transporters_Homo sapiens_hsa02010	0.47877146
88	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.46853630
89	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.45203268
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.43011755
91	Circadian entrainment_Homo sapiens_hsa04713	0.42445136
92	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.41968695
93	Asthma_Homo sapiens_hsa05310	0.41672647
94	Salivary secretion_Homo sapiens_hsa04970	0.40688405
95	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.40377584
96	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39980037
97	Glutathione metabolism_Homo sapiens_hsa00480	0.35656538
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.34738635
99	Histidine metabolism_Homo sapiens_hsa00340	0.33208667
100	Sphingolipid metabolism_Homo sapiens_hsa00600	0.32677997

RFTN1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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