RFTN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane organization (GO:0097090)7.12762775
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)6.98337046
3substrate-independent telencephalic tangential migration (GO:0021826)6.98337046
4axonal fasciculation (GO:0007413)6.15987906
5neuronal ion channel clustering (GO:0045161)5.90153416
6negative regulation of osteoblast proliferation (GO:0033689)5.58756646
7sodium ion export (GO:0071436)5.39608719
8neuron recognition (GO:0008038)4.65201948
9myelination (GO:0042552)4.54952592
10axon ensheathment (GO:0008366)4.43411942
11ensheathment of neurons (GO:0007272)4.43411942
12L-amino acid import (GO:0043092)4.39991569
13mechanosensory behavior (GO:0007638)4.39953929
14forebrain neuron differentiation (GO:0021879)4.32604717
15negative regulation of catenin import into nucleus (GO:0035414)4.28314252
16neuron cell-cell adhesion (GO:0007158)4.21309225
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.08507435
18layer formation in cerebral cortex (GO:0021819)4.03556226
19regulation of astrocyte differentiation (GO:0048710)4.00121686
20amino acid import (GO:0043090)3.89521402
21startle response (GO:0001964)3.89507725
22response to pheromone (GO:0019236)3.84887413
23nonmotile primary cilium assembly (GO:0035058)3.68232209
24regulation of neuronal synaptic plasticity (GO:0048168)3.55262921
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.54947397
26peripheral nervous system axon ensheathment (GO:0032292)3.54635762
27myelination in peripheral nervous system (GO:0022011)3.54635762
28response to inactivity (GO:0014854)3.51601063
29locomotory exploration behavior (GO:0035641)3.50772936
30pyrimidine nucleobase catabolic process (GO:0006208)3.49226454
31oligodendrocyte differentiation (GO:0048709)3.42130902
32negative regulation of cytosolic calcium ion concentration (GO:0051481)3.40511883
33righting reflex (GO:0060013)3.38413609
34dermatan sulfate biosynthetic process (GO:0030208)3.32338621
35adult walking behavior (GO:0007628)3.29877006
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.26715577
37semaphorin-plexin signaling pathway (GO:0071526)3.22840396
38auditory receptor cell stereocilium organization (GO:0060088)3.21032180
39behavioral response to nicotine (GO:0035095)3.20693215
40positive regulation of action potential (GO:0045760)3.20584862
41transmission of nerve impulse (GO:0019226)3.20252262
42regulation of osteoblast proliferation (GO:0033688)3.18475436
43response to auditory stimulus (GO:0010996)3.16876821
44protein polyglutamylation (GO:0018095)3.15597758
45positive regulation of male gonad development (GO:2000020)3.13754494
46platelet dense granule organization (GO:0060155)3.12821641
47dermatan sulfate metabolic process (GO:0030205)3.12227246
48negative regulation of protein localization to cell surface (GO:2000009)3.11548168
49C4-dicarboxylate transport (GO:0015740)3.10558822
50inner ear receptor stereocilium organization (GO:0060122)3.05662460
51positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)3.04829467
52cellular potassium ion homeostasis (GO:0030007)3.04658510
53presynaptic membrane assembly (GO:0097105)3.03686813
54reflex (GO:0060004)2.99223944
55epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.98946460
56protein localization to synapse (GO:0035418)2.98491922
57glutamate receptor signaling pathway (GO:0007215)2.95540360
58negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.95443122
59chondroitin sulfate catabolic process (GO:0030207)2.94973434
60appendage development (GO:0048736)2.94120645
61limb development (GO:0060173)2.94120645
62somite development (GO:0061053)2.94093605
63neurotransmitter uptake (GO:0001504)2.94057905
64extracellular matrix assembly (GO:0085029)2.92261550
65synaptic transmission, glutamatergic (GO:0035249)2.90719170
66retinal ganglion cell axon guidance (GO:0031290)2.88940400
67ovulation cycle (GO:0042698)2.85568704
68cyclic nucleotide catabolic process (GO:0009214)2.84939910
69potassium ion import (GO:0010107)2.84697259
70nucleobase catabolic process (GO:0046113)2.83596540
71synaptic vesicle maturation (GO:0016188)2.81114023
72retinal cone cell development (GO:0046549)2.80200710
73regulation of glial cell differentiation (GO:0045685)2.79464380
74vocalization behavior (GO:0071625)2.77214537
75negative regulation of neurotransmitter transport (GO:0051589)2.77003999
76extracellular fibril organization (GO:0043206)2.73890337
77myelin maintenance (GO:0043217)2.73370552
78cell communication by electrical coupling (GO:0010644)2.73280097
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72879124
80photoreceptor cell maintenance (GO:0045494)2.72636472
81cAMP catabolic process (GO:0006198)2.71910086
82G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71882278
83regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71337019
84detection of mechanical stimulus involved in sensory perception (GO:0050974)2.71048087
85positive regulation of synapse assembly (GO:0051965)2.71040008
86negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70055114
87photoreceptor cell differentiation (GO:0046530)2.69709906
88eye photoreceptor cell differentiation (GO:0001754)2.69709906
89positive regulation of dendritic spine development (GO:0060999)2.69553634
90limb bud formation (GO:0060174)2.69277116
91response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.65889787
92cellular response to sterol (GO:0036315)2.65549199
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.65373241
94dendrite morphogenesis (GO:0048813)2.65105211
95response to acidic pH (GO:0010447)2.65035755
96cilium morphogenesis (GO:0060271)2.62934328
97astrocyte differentiation (GO:0048708)2.62773167
98positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.62694461
99lateral sprouting from an epithelium (GO:0060601)2.61466831
100negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60863074
101negative regulation of translation, ncRNA-mediated (GO:0040033)2.60863074
102regulation of translation, ncRNA-mediated (GO:0045974)2.60863074
103positive regulation of synapse maturation (GO:0090129)2.60449232
104gonadal mesoderm development (GO:0007506)2.60431924
105atrial cardiac muscle cell action potential (GO:0086014)2.58701995
106telencephalon cell migration (GO:0022029)2.57985081
107regulation of male gonad development (GO:2000018)2.57974922
108neurotransmitter-gated ion channel clustering (GO:0072578)2.57087884
109regulation of axonogenesis (GO:0050770)2.56324424
110L-fucose catabolic process (GO:0042355)2.56315293
111fucose catabolic process (GO:0019317)2.56315293
112L-fucose metabolic process (GO:0042354)2.56315293
113cerebellar Purkinje cell differentiation (GO:0021702)2.55906679
114synapse assembly (GO:0007416)2.55019944
115postsynaptic membrane organization (GO:0001941)2.54734644
116cerebellar granule cell differentiation (GO:0021707)2.54064148
117positive regulation of oligodendrocyte differentiation (GO:0048714)2.53708666
118cell migration in hindbrain (GO:0021535)2.53561745
119cilium organization (GO:0044782)2.53509327
120negative regulation of axon extension (GO:0030517)2.53235619
121epithelial cilium movement (GO:0003351)2.52948688
122regulation of neurotransmitter uptake (GO:0051580)2.52852280
123membrane assembly (GO:0071709)2.52770250
124cilium assembly (GO:0042384)2.52487523
125otic vesicle formation (GO:0030916)2.52097472
126forebrain cell migration (GO:0021885)2.51921396
127positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.51897032
128regulation of dendritic spine morphogenesis (GO:0061001)2.51859909
129serotonin metabolic process (GO:0042428)2.51527114
130cellular response to cholesterol (GO:0071397)2.51381110
131intraciliary transport (GO:0042073)2.50178066
132regulation of synapse structural plasticity (GO:0051823)2.49850247
133regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49747555
134positive regulation of axonogenesis (GO:0050772)2.48630661
135potassium ion homeostasis (GO:0055075)2.47731389
136behavioral response to ethanol (GO:0048149)2.47214129
137neuronal action potential propagation (GO:0019227)2.47000285
138establishment of nucleus localization (GO:0040023)2.46653456
139regulation of synaptic transmission, glutamatergic (GO:0051966)2.46377875
140spinal cord development (GO:0021510)2.45882378
141cell morphogenesis involved in neuron differentiation (GO:0048667)2.45651569
142gamma-aminobutyric acid transport (GO:0015812)2.44614936
143axon development (GO:0061564)2.44225247
144regulation of dendritic spine development (GO:0060998)2.43965230
145central nervous system projection neuron axonogenesis (GO:0021952)2.43925563
146dendritic spine morphogenesis (GO:0060997)2.43287174
147cranial nerve development (GO:0021545)2.43040313
148neuronal action potential (GO:0019228)2.42900856
149regulation of cilium movement (GO:0003352)2.42505564
150long-term synaptic potentiation (GO:0060291)2.42432468
151cilium movement (GO:0003341)2.42251665
152acidic amino acid transport (GO:0015800)2.42155535
153spinal cord motor neuron differentiation (GO:0021522)2.41886333
154olfactory bulb development (GO:0021772)2.41654289
155cerebral cortex radially oriented cell migration (GO:0021799)2.41583279
156exploration behavior (GO:0035640)2.41501829
157cellular response to electrical stimulus (GO:0071257)2.41376212
158regulation of collateral sprouting (GO:0048670)2.41309299
159negative regulation of axonogenesis (GO:0050771)2.40958772
160auditory behavior (GO:0031223)2.40319498
161regulation of synaptic plasticity (GO:0048167)2.40215097
162ureteric bud development (GO:0001657)2.39809222
163acrosome reaction (GO:0007340)2.39152772
164central nervous system myelination (GO:0022010)11.2238463
165axon ensheathment in central nervous system (GO:0032291)11.2238463

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.51934884
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.26689212
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24853771
4AR_21572438_ChIP-Seq_LNCaP_Human3.14783217
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10844754
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10196888
7EZH2_27304074_Chip-Seq_ESCs_Mouse3.09414423
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.99011533
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98918752
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.98814382
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.98814382
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.87937489
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.73603049
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70463412
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60028093
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.55953396
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49487384
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.49051311
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.30541868
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.30485554
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.30272010
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24910855
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.24622207
24GBX2_23144817_ChIP-Seq_PC3_Human2.24416514
25FUS_26573619_Chip-Seq_HEK293_Human2.24209887
26VDR_22108803_ChIP-Seq_LS180_Human2.16474195
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.16258379
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10015699
29EWS_26573619_Chip-Seq_HEK293_Human2.08292215
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.06167890
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.03886861
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00197343
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93264650
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.77415941
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72802701
36RING1B_27294783_Chip-Seq_ESCs_Mouse1.70977182
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70500303
38BCAT_22108803_ChIP-Seq_LS180_Human1.62904562
39* STAT3_23295773_ChIP-Seq_U87_Human1.60863545
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60672858
41DROSHA_22980978_ChIP-Seq_HELA_Human1.59566927
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57830448
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55997554
44AR_25329375_ChIP-Seq_VCAP_Human1.54652404
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.51718378
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51493407
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50793887
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46439453
49TCF4_23295773_ChIP-Seq_U87_Human1.45813909
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45175394
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.43842955
52REST_21632747_ChIP-Seq_MESCs_Mouse1.43716160
53RXR_22108803_ChIP-Seq_LS180_Human1.43302432
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42864877
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.40150631
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38528684
57TP53_20018659_ChIP-ChIP_R1E_Mouse1.38019710
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35422674
59NANOG_18555785_Chip-Seq_ESCs_Mouse1.35035632
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33156904
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31350806
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.31040586
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29886715
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29575354
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.28180253
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26317924
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26126631
68KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25732635
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25482726
70VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.24803886
71ERG_21242973_ChIP-ChIP_JURKAT_Human1.24432174
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.23833587
73TCF4_22108803_ChIP-Seq_LS180_Human1.23821539
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23733528
75REST_18959480_ChIP-ChIP_MESCs_Mouse1.21852954
76* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21125740
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20581575
78FLI1_21867929_ChIP-Seq_TH2_Mouse1.20029891
79EP300_21415370_ChIP-Seq_HL-1_Mouse1.19340147
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18854072
81CBP_20019798_ChIP-Seq_JUKART_Human1.18854072
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17093142
83P53_22387025_ChIP-Seq_ESCs_Mouse1.16946719
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16213162
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15553684
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14789272
87* P300_19829295_ChIP-Seq_ESCs_Human1.14372740
88* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14091464
89* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13803390
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.13680609
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12365092
92NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12365092
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10681553
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09735318
95NANOG_19829295_ChIP-Seq_ESCs_Human1.09338014
96SOX2_19829295_ChIP-Seq_ESCs_Human1.09338014
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08985008
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.07754704
99CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07522391
100* SOX9_26525672_Chip-Seq_HEART_Mouse1.07217038
101SMAD4_21741376_ChIP-Seq_EPCs_Human1.07045957
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06773533
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06681431
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06575892
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06553237
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05837414
107PRDM14_20953172_ChIP-Seq_ESCs_Human1.05825206
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.05488863
109* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05459551
110KDM2B_26808549_Chip-Seq_REH_Human1.05102451
111ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05009888
112CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04840388
113TP53_16413492_ChIP-PET_HCT116_Human1.04330023
114SMAD4_21799915_ChIP-Seq_A2780_Human1.03994636
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.01161857
116PIAS1_25552417_ChIP-Seq_VCAP_Human0.99440078
117IGF1R_20145208_ChIP-Seq_DFB_Human0.98060562
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97801855
119P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96894151
120TAF15_26573619_Chip-Seq_HEK293_Human0.92873734
121RNF2_27304074_Chip-Seq_NSC_Mouse0.92758622
122* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.92529752
123TP53_18474530_ChIP-ChIP_U2OS_Human0.90763561
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89922308
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89255084
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.87904056
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86774952
128NR3C1_23031785_ChIP-Seq_PC12_Mouse0.86660995
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85818063
130AR_19668381_ChIP-Seq_PC3_Human0.85600780
131MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84490039
132ER_23166858_ChIP-Seq_MCF-7_Human0.84423267
133KDM2B_26808549_Chip-Seq_K562_Human0.84196940
134SOX2_21211035_ChIP-Seq_LN229_Gbm0.83964559
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83886104
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83679886
137GATA1_26923725_Chip-Seq_HPCs_Mouse0.83098440
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82904370
139* RUNX2_22187159_ChIP-Seq_PCA_Human0.81367307
140ISL1_27105846_Chip-Seq_CPCs_Mouse0.79546272
141UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79518283
142TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78220768
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.78220768
144ZNF274_21170338_ChIP-Seq_K562_Hela0.77745427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005423_abnormal_somatic_nervous6.17146193
2MP0004859_abnormal_synaptic_plasticity3.55235161
3MP0002736_abnormal_nociception_after3.32037447
4MP0009384_cardiac_valve_regurgitation3.27325854
5MP0000778_abnormal_nervous_system2.78360493
6MP0002653_abnormal_ependyma_morphology2.58674973
7MP0003880_abnormal_central_pattern2.43334182
8MP0005645_abnormal_hypothalamus_physiol2.35835927
9MP0004134_abnormal_chest_morphology2.30523328
10MP0001486_abnormal_startle_reflex2.30223291
11MP0000920_abnormal_myelination2.29799005
12MP0000569_abnormal_digit_pigmentation2.25797494
13MP0004270_analgesia2.18363730
14MP0003635_abnormal_synaptic_transmissio2.14989959
15MP0005551_abnormal_eye_electrophysiolog2.12944436
16MP0008438_abnormal_cutaneous_collagen2.09025182
17MP0005623_abnormal_meninges_morphology2.08658174
18MP0010030_abnormal_orbit_morphology1.97778031
19MP0008995_early_reproductive_senescence1.93329178
20MP0005503_abnormal_tendon_morphology1.92361732
21MP0001485_abnormal_pinna_reflex1.90672857
22MP0002064_seizures1.90328514
23MP0003183_abnormal_peptide_metabolism1.90119639
24MP0002282_abnormal_trachea_morphology1.89544740
25MP0002638_abnormal_pupillary_reflex1.89465768
26MP0005253_abnormal_eye_physiology1.86860608
27MP0002735_abnormal_chemical_nociception1.85401834
28MP0004885_abnormal_endolymph1.82895814
29MP0003122_maternal_imprinting1.78005610
30MP0003690_abnormal_glial_cell1.77548148
31MP0009250_abnormal_appendicular_skeleto1.77321994
32MP0002063_abnormal_learning/memory/cond1.74121149
33MP0008877_abnormal_DNA_methylation1.72214227
34MP0003634_abnormal_glial_cell1.66986045
35MP0005646_abnormal_pituitary_gland1.66980845
36MP0008569_lethality_at_weaning1.65940378
37MP0003195_calcinosis1.63818149
38MP0000955_abnormal_spinal_cord1.62964200
39MP0004858_abnormal_nervous_system1.62901838
40MP0003329_amyloid_beta_deposits1.60451118
41MP0009046_muscle_twitch1.60216533
42MP0006072_abnormal_retinal_apoptosis1.58711660
43MP0009745_abnormal_behavioral_response1.57500560
44MP0000631_abnormal_neuroendocrine_gland1.55573709
45MP0004147_increased_porphyrin_level1.55561529
46MP0003787_abnormal_imprinting1.53661113
47MP0006054_spinal_hemorrhage1.48153239
48MP0001299_abnormal_eye_distance/1.48028095
49MP0006276_abnormal_autonomic_nervous1.45982882
50MP0003942_abnormal_urinary_system1.45933417
51MP0002572_abnormal_emotion/affect_behav1.42644144
52MP0001986_abnormal_taste_sensitivity1.42311842
53MP0002272_abnormal_nervous_system1.42266350
54MP0000516_abnormal_urinary_system1.40006006
55MP0005367_renal/urinary_system_phenotyp1.40006006
56MP0002733_abnormal_thermal_nociception1.38080583
57MP0003137_abnormal_impulse_conducting1.37512955
58MP0004145_abnormal_muscle_electrophysio1.35696916
59MP0005187_abnormal_penis_morphology1.35219014
60MP0003172_abnormal_lysosome_physiology1.35105549
61MP0005171_absent_coat_pigmentation1.34331307
62MP0000026_abnormal_inner_ear1.31985180
63MP0002882_abnormal_neuron_morphology1.30917226
64MP0002095_abnormal_skin_pigmentation1.29365626
65MP0000462_abnormal_digestive_system1.29105310
66MP0002102_abnormal_ear_morphology1.28408701
67MP0001963_abnormal_hearing_physiology1.28279754
68MP0001440_abnormal_grooming_behavior1.26618567
69MP0003011_delayed_dark_adaptation1.21820853
70MP0001970_abnormal_pain_threshold1.19974594
71MP0002734_abnormal_mechanical_nocicepti1.19941560
72MP0005174_abnormal_tail_pigmentation1.19238098
73MP0002184_abnormal_innervation1.19121915
74MP0001984_abnormal_olfaction1.18523318
75MP0001958_emphysema1.17743106
76MP0003136_yellow_coat_color1.17518446
77MP0004811_abnormal_neuron_physiology1.17057860
78MP0000534_abnormal_ureter_morphology1.16405933
79MP0004133_heterotaxia1.14904226
80MP0003632_abnormal_nervous_system1.13819602
81MP0002152_abnormal_brain_morphology1.13032199
82MP0003385_abnormal_body_wall1.12748561
83MP0001346_abnormal_lacrimal_gland1.12168226
84MP0005167_abnormal_blood-brain_barrier1.11786441
85MP0004742_abnormal_vestibular_system1.11313884
86MP0003279_aneurysm1.10515931
87MP0002066_abnormal_motor_capabilities/c1.06410151
88MP0004215_abnormal_myocardial_fiber1.06216702
89MP0005386_behavior/neurological_phenoty1.05047142
90MP0004924_abnormal_behavior1.05047142
91MP0003950_abnormal_plasma_membrane1.04933915
92MP0000427_abnormal_hair_cycle1.04347734
93MP0005195_abnormal_posterior_eye1.03838335
94MP0002837_dystrophic_cardiac_calcinosis1.03766930
95MP0006292_abnormal_olfactory_placode1.03715578
96MP0005410_abnormal_fertilization1.03596611
97MP0000733_abnormal_muscle_development1.03248449
98MP0000049_abnormal_middle_ear1.02735433
99MP0000647_abnormal_sebaceous_gland1.02036934
100MP0003633_abnormal_nervous_system1.00474020
101MP0003631_nervous_system_phenotype1.00175380
102MP0000428_abnormal_craniofacial_morphol1.00083810
103MP0002249_abnormal_larynx_morphology0.99378133
104MP0008872_abnormal_physiological_respon0.98609850
105MP0000751_myopathy0.98044966
106MP0003121_genomic_imprinting0.97578013
107MP0005248_abnormal_Harderian_gland0.97269122
108MP0002067_abnormal_sensory_capabilities0.96729136
109MP0003755_abnormal_palate_morphology0.96424219
110MP0005391_vision/eye_phenotype0.96146598
111MP0000372_irregular_coat_pigmentation0.96034422
112MP0002133_abnormal_respiratory_system0.95636162
113MP0005388_respiratory_system_phenotype0.95636162
114MP0001529_abnormal_vocalization0.95280241
115MP0003115_abnormal_respiratory_system0.94340754
116MP0003937_abnormal_limbs/digits/tail_de0.94213061
117MP0001502_abnormal_circadian_rhythm0.94155007
118MP0002932_abnormal_joint_morphology0.92755021
119MP0005508_abnormal_skeleton_morphology0.91418137
120MP0001177_atelectasis0.91404182
121MP0001501_abnormal_sleep_pattern0.89026052
122MP0002557_abnormal_social/conspecific_i0.87398867
123MP0003861_abnormal_nervous_system0.87339057
124MP0001968_abnormal_touch/_nociception0.87149863
125MP0002938_white_spotting0.87084112
126MP0002295_abnormal_pulmonary_circulatio0.86762074
127MP0002108_abnormal_muscle_morphology0.86752084
128MP0002752_abnormal_somatic_nervous0.86232069
129MP0000383_abnormal_hair_follicle0.86199254
130MP0004142_abnormal_muscle_tone0.86180731
131MP0002909_abnormal_adrenal_gland0.86118959
132MP0002116_abnormal_craniofacial_bone0.85469344
133MP0004272_abnormal_basement_membrane0.84959436
134MP0006138_congestive_heart_failure0.84595906
135MP0002229_neurodegeneration0.83813285
136MP0004043_abnormal_pH_regulation0.82801090
137MP0002233_abnormal_nose_morphology0.82166268
138MP0001905_abnormal_dopamine_level0.82085661
139MP0001293_anophthalmia0.81803474
140MP0004484_altered_response_of0.80256830
141MP0001943_abnormal_respiration0.79277224
142MP0002234_abnormal_pharynx_morphology0.78232746
143MP0002928_abnormal_bile_duct0.77105915
144MP0009780_abnormal_chondrocyte_physiolo0.75556217
145MP0002751_abnormal_autonomic_nervous0.75100401
146MP0003119_abnormal_digestive_system0.74458008
147MP0003938_abnormal_ear_development0.73568433

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)4.68462323
2Hyperventilation (HP:0002883)4.54828455
3True hermaphroditism (HP:0010459)4.31817800
4Abnormal eating behavior (HP:0100738)4.15568202
5Pancreatic fibrosis (HP:0100732)3.97127488
6Pancreatic cysts (HP:0001737)3.94444170
7Aplasia of the phalanges of the hand (HP:0009802)3.59671370
8Aplasia involving bones of the extremities (HP:0009825)3.59671370
9Aplasia involving bones of the upper limbs (HP:0009823)3.59671370
10Neurofibrillary tangles (HP:0002185)3.55257369
11Molar tooth sign on MRI (HP:0002419)3.41583194
12Abnormality of midbrain morphology (HP:0002418)3.41583194
13Septo-optic dysplasia (HP:0100842)3.21203568
14Congenital sensorineural hearing impairment (HP:0008527)3.15859646
15Nephronophthisis (HP:0000090)3.15626451
16Peripheral hypomyelination (HP:0007182)3.05874308
17Abnormality of dentin (HP:0010299)3.02531680
18Intestinal atresia (HP:0011100)3.01141630
19Vitreoretinal degeneration (HP:0000655)2.99422222
20Medial flaring of the eyebrow (HP:0010747)2.98942733
21Abnormal sex determination (HP:0012244)2.93237988
22Sex reversal (HP:0012245)2.93237988
23Buphthalmos (HP:0000557)2.92779864
24Premature rupture of membranes (HP:0001788)2.88462686
25Type II lissencephaly (HP:0007260)2.85489552
26Abnormality of the renal medulla (HP:0100957)2.84055871
27High anterior hairline (HP:0009890)2.81586876
28Cystic liver disease (HP:0006706)2.77516173
29Gait imbalance (HP:0002141)2.77440510
30Chronic hepatic failure (HP:0100626)2.74411581
31Optic nerve hypoplasia (HP:0000609)2.72926344
32Microglossia (HP:0000171)2.70000781
33Coronal craniosynostosis (HP:0004440)2.61778543
34Abnormality of the middle phalanges of the toes (HP:0010183)2.55446717
35Congenital primary aphakia (HP:0007707)2.55302038
36Genital tract atresia (HP:0001827)2.53376224
37Short 4th metacarpal (HP:0010044)2.52659865
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.52659865
39Aplasia/Hypoplasia of the tongue (HP:0010295)2.52600842
40Bell-shaped thorax (HP:0001591)2.52000175
41Myokymia (HP:0002411)2.51945595
42Absent speech (HP:0001344)2.50467407
43Atonic seizures (HP:0010819)2.47492360
44Febrile seizures (HP:0002373)2.47489866
45Onion bulb formation (HP:0003383)2.46799086
46Vaginal atresia (HP:0000148)2.43468549
47Abolished electroretinogram (ERG) (HP:0000550)2.42645526
48Cerebral inclusion bodies (HP:0100314)2.42397778
49Gaze-evoked nystagmus (HP:0000640)2.41705505
50Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.39536813
51Congenital stationary night blindness (HP:0007642)2.38592668
52Oligodactyly (hands) (HP:0001180)2.35186098
53Occipital encephalocele (HP:0002085)2.34670514
54Aplasia/Hypoplasia of the tibia (HP:0005772)2.33906890
55Postaxial foot polydactyly (HP:0001830)2.33877383
56Progressive cerebellar ataxia (HP:0002073)2.33855625
57Sclerocornea (HP:0000647)2.31541823
58Postaxial hand polydactyly (HP:0001162)2.31517710
59Focal motor seizures (HP:0011153)2.28076714
60Abnormality of the phalanges of the 2nd finger (HP:0009541)2.26491881
61Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26034148
62Degeneration of the lateral corticospinal tracts (HP:0002314)2.26034148
63Nephrogenic diabetes insipidus (HP:0009806)2.25325646
64Congenital hepatic fibrosis (HP:0002612)2.24042152
65Shallow orbits (HP:0000586)2.23951669
66Gastrointestinal atresia (HP:0002589)2.23914293
67Midline defect of the nose (HP:0004122)2.23238651
68Anencephaly (HP:0002323)2.22793812
69Protrusio acetabuli (HP:0003179)2.22744341
70Hypoplastic pelvis (HP:0008839)2.22696089
71Anteriorly placed anus (HP:0001545)2.22213970
72Chorioretinal atrophy (HP:0000533)2.21696031
73Neonatal short-limb short stature (HP:0008921)2.18638550
74Cerebellar dysplasia (HP:0007033)2.17506749
75Bladder diverticulum (HP:0000015)2.17164462
76Epiphyseal dysplasia (HP:0002656)2.15466944
77Abnormality of the renal cortex (HP:0011035)2.15064892
78Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14646817
79Intention tremor (HP:0002080)2.13789890
80Hemiparesis (HP:0001269)2.13381001
81Dialeptic seizures (HP:0011146)2.13365436
82Split foot (HP:0001839)2.13012532
83Action tremor (HP:0002345)2.12945938
84Abnormality of the ischium (HP:0003174)2.12340480
85Hammertoe (HP:0001765)2.11756691
86Humeroradial synostosis (HP:0003041)2.11285605
87Synostosis involving the elbow (HP:0003938)2.11285605
88Stomach cancer (HP:0012126)2.09969380
89Attenuation of retinal blood vessels (HP:0007843)2.07254756
90Overriding aorta (HP:0002623)2.06748311
91Broad metatarsal (HP:0001783)2.06366990
92Supranuclear gaze palsy (HP:0000605)2.06107604
93Male pseudohermaphroditism (HP:0000037)2.04505946
94Preaxial hand polydactyly (HP:0001177)2.04306002
95Drooling (HP:0002307)2.04250908
96Furrowed tongue (HP:0000221)2.04152327
97Pendular nystagmus (HP:0012043)2.04077058
98Renal hypoplasia (HP:0000089)2.02527128
99Generalized tonic-clonic seizures (HP:0002069)2.00674456
100Overgrowth (HP:0001548)2.00204526
101Abnormality of the 4th metacarpal (HP:0010012)2.00081331
102Flat capital femoral epiphysis (HP:0003370)1.99901190
103Increased variability in muscle fiber diameter (HP:0003557)1.99317134
104Anophthalmia (HP:0000528)1.98718184
105Large for gestational age (HP:0001520)1.93780026
106Short hallux (HP:0010109)1.91698520
107Scanning speech (HP:0002168)1.91469750
108Bile duct proliferation (HP:0001408)1.91193480
109Abnormal biliary tract physiology (HP:0012439)1.91193480
110Abnormality of the diencephalon (HP:0010662)1.91058532
111Lissencephaly (HP:0001339)1.90369226
112Colon cancer (HP:0003003)1.90201428
113Fetal akinesia sequence (HP:0001989)1.90099742
114Submucous cleft hard palate (HP:0000176)1.88406935
115Insidious onset (HP:0003587)1.88403698
116Termporal pattern (HP:0011008)1.88403698
117Retinal dysplasia (HP:0007973)1.88260815
118Polyphagia (HP:0002591)1.88110221
119Tracheomalacia (HP:0002779)1.87317811
120Widely spaced teeth (HP:0000687)1.87164759
121Short tibia (HP:0005736)1.86996729
122Fibular aplasia (HP:0002990)1.86762559
123Alacrima (HP:0000522)1.86482080
124Fibular hypoplasia (HP:0003038)1.85736884
125Long nose (HP:0003189)1.85357766
126Bifid scrotum (HP:0000048)1.84981700
127Atelectasis (HP:0100750)1.84700327
128Specific learning disability (HP:0001328)1.83954317
129Hypoplastic ischia (HP:0003175)1.83214678
130Hyperextensible skin (HP:0000974)1.81990564
131Flat cornea (HP:0007720)1.81788656
132Broad-based gait (HP:0002136)1.79819531
133Aplasia/Hypoplasia of the clavicles (HP:0006710)1.79569173
134Segmental peripheral demyelination/remyelination (HP:0003481)1.79282067
135Poor coordination (HP:0002370)1.79053669
136Excessive salivation (HP:0003781)1.78668266
137Abnormality of the corticospinal tract (HP:0002492)1.78440243
138Bronchomalacia (HP:0002780)1.78198265
139Abnormal drinking behavior (HP:0030082)1.77500913
140Polydipsia (HP:0001959)1.77500913
141Inability to walk (HP:0002540)1.77277358
142Narrow forehead (HP:0000341)1.77203809
143Tubular atrophy (HP:0000092)1.76357553
144Broad ribs (HP:0000885)1.76087800
145Wide anterior fontanel (HP:0000260)1.75902971
146Abnormality of macular pigmentation (HP:0008002)1.75633905
147Adactyly (HP:0009776)1.75593713
148Decreased central vision (HP:0007663)1.75541344
149Relative macrocephaly (HP:0004482)1.74653298
150Absence seizures (HP:0002121)1.74502805
151Aplasia/Hypoplasia of the hallux (HP:0008362)1.74258229
152Renal dysplasia (HP:0000110)1.73689145
153Sleep apnea (HP:0010535)1.73305716
154Keratoconus (HP:0000563)1.72772877
155Increased corneal curvature (HP:0100692)1.72772877
156Astigmatism (HP:0000483)1.72589044
157Tented upper lip vermilion (HP:0010804)1.72522044
158Cutaneous finger syndactyly (HP:0010554)1.71161286
159Broad foot (HP:0001769)1.70507552
160Congenital, generalized hypertrichosis (HP:0004540)1.69739472
161Round face (HP:0000311)1.69515165
162Epileptic encephalopathy (HP:0200134)1.69291618
163Esotropia (HP:0000565)1.68785734
164Limited hip movement (HP:0008800)1.68534260
165Epidermoid cyst (HP:0200040)1.68430586
166Focal seizures (HP:0007359)1.67907374
167Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.67740330
168Aplasia/Hypoplasia of the fibula (HP:0006492)1.67611264
169Congenital glaucoma (HP:0001087)1.67545070
170Abnormal ciliary motility (HP:0012262)1.66517459
171Clumsiness (HP:0002312)1.66050659
172Dysmetria (HP:0001310)1.64711956
173Abnormality of the parietal bone (HP:0002696)1.64520067
174Short clavicles (HP:0000894)1.61868116
175Trigonocephaly (HP:0000243)1.61441694
176Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60324708
177Premature skin wrinkling (HP:0100678)1.59404353
178Abnormality of the 2nd finger (HP:0004100)1.59338439
179Aplasia of the musculature (HP:0100854)1.58940467
180Infantile muscular hypotonia (HP:0008947)1.58196358
181Hypoplastic heart (HP:0001961)1.57520511
182Preaxial foot polydactyly (HP:0001841)1.57476011
183Hemiplegia (HP:0002301)1.57219574
184Insomnia (HP:0100785)1.56980997
185Abnormal auditory evoked potentials (HP:0006958)1.56760042

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA38.45252114
2FRK3.83875065
3PNCK3.06763824
4IRAK22.74588219
5EPHA42.66352909
6WNK32.50517603
7MAP4K22.26018092
8PAK62.20073201
9STK392.11015500
10PINK12.06452854
11CASK2.04455468
12ERBB21.98160540
13IRAK11.86202950
14NTRK21.85921240
15MKNK21.82071143
16DDR21.80727440
17ROCK21.77822397
18RIPK11.77684250
19INSRR1.76174183
20ACVR1B1.75581922
21WEE11.70392543
22PRKD31.68481931
23MAPKAPK51.64954019
24ADRBK21.60333487
25PHKG21.57914836
26PHKG11.57914836
27NUAK11.55724242
28KSR21.54020161
29NTRK31.53657194
30PAK31.53588008
31TESK21.46773886
32TIE11.41429902
33BRD41.35392195
34SGK4941.34879044
35SGK2231.34879044
36TRIM281.33571775
37PRPF4B1.32275748
38GRK11.31794161
39STK38L1.29412154
40FGFR21.28577251
41TNIK1.26254474
42LIMK11.25991862
43LMTK21.25615949
44OXSR11.24090359
45TYRO31.21735861
46UHMK11.18343789
47PKN11.18200858
48PTK2B1.16383192
49BCR1.14943488
50ROCK11.12807510
51EPHB11.06501883
52NTRK11.05127583
53DMPK1.05102967
54MKNK11.03533604
55CDK51.03218689
56TGFBR11.01020500
57ILK1.00843532
58MARK10.99166524
59MAPK150.97886331
60LATS20.97767361
61CAMK2B0.95156349
62NEK60.92772053
63TRIB30.92153358
64EPHB20.90191210
65MAP3K40.88095169
66MAP3K130.87701838
67MET0.86617692
68IRAK40.84885160
69KSR10.83912070
70CDK140.80363606
71ZAK0.79554627
72CDK150.79342893
73ERBB30.78470460
74NLK0.77777457
75RPS6KA20.75130676
76BMX0.74914908
77CAMK1G0.73853385
78CDK180.73848288
79CDK30.73615937
80FGR0.71874740
81PDGFRA0.71692624
82CAMK2A0.70034060
83DAPK20.69715475
84PLK30.69537801
85ICK0.69271791
86PRKCE0.68289422
87MAPK130.68017082
88PLK20.67962806
89CDK11A0.67956724
90WNK10.67928357
91MARK20.66511870
92DYRK1A0.66217038
93PIK3CA0.65892730
94TLK10.64525726
95PRKCH0.61593363
96MINK10.61552374
97CAMK2D0.61361319
98VRK10.61334070
99PRKD10.60570647
100ERBB40.60355447
101CAMK1D0.60286229
102FER0.60132360
103CSNK1A1L0.56918372
104TSSK60.56432786
105MAPK120.56340319
106CAMK2G0.56327599
107TAF10.55055660
108PAK20.54411468
109PRKCZ0.53442256
110FES0.52709133
111MAPK100.49542720
112MUSK0.49112788
113PRKCG0.48279596
114GRK50.46787242
115CSNK1G30.46527676
116YES10.46319075
117RAF10.45760846
118ADRBK10.45719844
119TAOK30.45338946
120PRKACA0.45054230
121PDGFRB0.44143505
122TESK10.43633846
123DYRK20.43607171
124DAPK30.43386210
125SGK20.43367773
126CSNK1G20.43145387
127PRKCQ0.42848872
128STK110.41795945
129SGK10.41399186
130WNK40.40866753
131CAMKK20.40615157
132CSNK1D0.40402661
133MAPK90.39641508
134CCNB10.39340058
135PBK0.39303366
136CSNK1A10.38891182
137MAP2K70.38870153
138CSNK1G10.38524301
139PRKG10.38520136
140BMPR1B0.38195559
141CAMK10.37224109
142FGFR10.36674607
143CDK190.35966934
144STK30.35706691
145BRSK20.32717462
146AKT30.32131583

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.91346580
2Axon guidance_Homo sapiens_hsa043602.91580424
3Butanoate metabolism_Homo sapiens_hsa006502.28576516
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10506891
5Phototransduction_Homo sapiens_hsa047442.09210192
6GABAergic synapse_Homo sapiens_hsa047272.05960396
7Glutamatergic synapse_Homo sapiens_hsa047241.96825117
8Protein export_Homo sapiens_hsa030601.94151918
9Circadian entrainment_Homo sapiens_hsa047131.92368810
10Propanoate metabolism_Homo sapiens_hsa006401.91237040
11Salivary secretion_Homo sapiens_hsa049701.86737956
12Nicotine addiction_Homo sapiens_hsa050331.82751372
13Gastric acid secretion_Homo sapiens_hsa049711.79838547
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.69017969
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.66264899
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63101724
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60365935
18Morphine addiction_Homo sapiens_hsa050321.58595986
19Basal cell carcinoma_Homo sapiens_hsa052171.53780010
20Hedgehog signaling pathway_Homo sapiens_hsa043401.53466996
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49389554
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49252687
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46219621
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44949024
25Linoleic acid metabolism_Homo sapiens_hsa005911.44202370
26Cocaine addiction_Homo sapiens_hsa050301.41962006
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36823948
28beta-Alanine metabolism_Homo sapiens_hsa004101.36094082
29Long-term depression_Homo sapiens_hsa047301.34944628
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34892684
31Dopaminergic synapse_Homo sapiens_hsa047281.31630511
32ECM-receptor interaction_Homo sapiens_hsa045121.31621505
33Cardiac muscle contraction_Homo sapiens_hsa042601.30384480
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29942551
35Long-term potentiation_Homo sapiens_hsa047201.29932678
36Renin secretion_Homo sapiens_hsa049241.28302680
37Gap junction_Homo sapiens_hsa045401.27014400
38Basal transcription factors_Homo sapiens_hsa030221.26726244
39Amphetamine addiction_Homo sapiens_hsa050311.25447337
40Dorso-ventral axis formation_Homo sapiens_hsa043201.24519747
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23805219
42Olfactory transduction_Homo sapiens_hsa047401.23739269
43Fatty acid biosynthesis_Homo sapiens_hsa000611.22813145
44Dilated cardiomyopathy_Homo sapiens_hsa054141.20210407
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19636933
46Cholinergic synapse_Homo sapiens_hsa047251.19557975
47ABC transporters_Homo sapiens_hsa020101.19311905
48Histidine metabolism_Homo sapiens_hsa003401.18399746
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18264363
50Fanconi anemia pathway_Homo sapiens_hsa034601.17342374
51cAMP signaling pathway_Homo sapiens_hsa040241.15393460
52Steroid biosynthesis_Homo sapiens_hsa001001.14579568
53Sphingolipid signaling pathway_Homo sapiens_hsa040711.14104538
54Fatty acid elongation_Homo sapiens_hsa000621.13956314
55Tryptophan metabolism_Homo sapiens_hsa003801.13525683
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11421535
57Insulin secretion_Homo sapiens_hsa049111.08787010
58Renal cell carcinoma_Homo sapiens_hsa052111.08721895
59Melanogenesis_Homo sapiens_hsa049161.08590854
60Serotonergic synapse_Homo sapiens_hsa047261.08443191
61Phospholipase D signaling pathway_Homo sapiens_hsa040721.07858300
62Hippo signaling pathway_Homo sapiens_hsa043901.06481602
63Circadian rhythm_Homo sapiens_hsa047101.04637189
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02607244
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.99928041
66Ether lipid metabolism_Homo sapiens_hsa005650.99551200
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98301485
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97610764
69Oxytocin signaling pathway_Homo sapiens_hsa049210.97261453
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.94891291
71Pancreatic secretion_Homo sapiens_hsa049720.94541971
72Calcium signaling pathway_Homo sapiens_hsa040200.93940440
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93363066
74Glioma_Homo sapiens_hsa052140.93150356
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.91568464
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90977356
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.90819057
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90691380
79Peroxisome_Homo sapiens_hsa041460.89688070
80Focal adhesion_Homo sapiens_hsa045100.89502584
81Glycerolipid metabolism_Homo sapiens_hsa005610.89493213
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.88747576
83Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88045514
84Wnt signaling pathway_Homo sapiens_hsa043100.87992982
85Protein digestion and absorption_Homo sapiens_hsa049740.86009298
86Homologous recombination_Homo sapiens_hsa034400.82144663
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81394856
88Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77695927
89Fatty acid metabolism_Homo sapiens_hsa012120.77418699
90Synaptic vesicle cycle_Homo sapiens_hsa047210.77263158
91Regulation of autophagy_Homo sapiens_hsa041400.77181573
92Rap1 signaling pathway_Homo sapiens_hsa040150.77112370
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76731666
94Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76476915
95Sphingolipid metabolism_Homo sapiens_hsa006000.76107567
96Oxidative phosphorylation_Homo sapiens_hsa001900.75814767
97Vitamin B6 metabolism_Homo sapiens_hsa007500.75158847
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.74890259
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74857589
100Estrogen signaling pathway_Homo sapiens_hsa049150.74713760
101GnRH signaling pathway_Homo sapiens_hsa049120.74257132
102ErbB signaling pathway_Homo sapiens_hsa040120.73524538
103Endocytosis_Homo sapiens_hsa041440.73253180
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71790772
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69657261
106Ras signaling pathway_Homo sapiens_hsa040140.69162517
107Proteoglycans in cancer_Homo sapiens_hsa052050.68749579
108Tight junction_Homo sapiens_hsa045300.67663601
109Bile secretion_Homo sapiens_hsa049760.67090250
110MicroRNAs in cancer_Homo sapiens_hsa052060.65258291
111Endometrial cancer_Homo sapiens_hsa052130.65229475
112Ovarian steroidogenesis_Homo sapiens_hsa049130.63637986
113Choline metabolism in cancer_Homo sapiens_hsa052310.63374253
114Chemical carcinogenesis_Homo sapiens_hsa052040.62993258
115Notch signaling pathway_Homo sapiens_hsa043300.62859028
116Selenocompound metabolism_Homo sapiens_hsa004500.61874189
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61290530
118Caffeine metabolism_Homo sapiens_hsa002320.61240438
119Taste transduction_Homo sapiens_hsa047420.60880195
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.60752650
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60708804
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.59383070
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57565969
124MAPK signaling pathway_Homo sapiens_hsa040100.56544850
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56280058
126Parkinsons disease_Homo sapiens_hsa050120.54928270
127RNA polymerase_Homo sapiens_hsa030200.54847081
128Lysine degradation_Homo sapiens_hsa003100.53324472
129Collecting duct acid secretion_Homo sapiens_hsa049660.53117927
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52358961
131Fatty acid degradation_Homo sapiens_hsa000710.51311164
132Arginine and proline metabolism_Homo sapiens_hsa003300.50897417
133Mineral absorption_Homo sapiens_hsa049780.49693638
134Retinol metabolism_Homo sapiens_hsa008300.49257257
135Thyroid hormone synthesis_Homo sapiens_hsa049180.49214295
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48747151
137Prostate cancer_Homo sapiens_hsa052150.48361626
138TGF-beta signaling pathway_Homo sapiens_hsa043500.43270073
139PPAR signaling pathway_Homo sapiens_hsa033200.42578167
140Alzheimers disease_Homo sapiens_hsa050100.42555663
141Melanoma_Homo sapiens_hsa052180.40063077
142VEGF signaling pathway_Homo sapiens_hsa043700.39585904

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