RFWD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)5.39642000
2response to peptidoglycan (GO:0032494)4.76659531
3neutrophil activation involved in immune response (GO:0002283)4.75518727
4regulation of B cell receptor signaling pathway (GO:0050855)4.60381981
5macrophage activation involved in immune response (GO:0002281)4.53045061
6cellular extravasation (GO:0045123)4.39874984
7detection of external biotic stimulus (GO:0098581)4.39060772
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.38119307
9negative regulation of cell killing (GO:0031342)4.38119307
10negative regulation of interleukin-12 production (GO:0032695)4.21765396
11monoubiquitinated protein deubiquitination (GO:0035520)4.12323829
12regulation of gamma-delta T cell activation (GO:0046643)4.10885214
13cytoplasmic mRNA processing body assembly (GO:0033962)4.07612766
14positive regulation of B cell differentiation (GO:0045579)4.01931216
15detection of bacterium (GO:0016045)3.98783803
16synapsis (GO:0007129)3.93443720
17mitotic sister chromatid cohesion (GO:0007064)3.87493648
18detection of biotic stimulus (GO:0009595)3.87439678
19microglial cell activation (GO:0001774)3.85402275
20neutrophil mediated immunity (GO:0002446)3.67291066
21regulation of interferon-beta biosynthetic process (GO:0045357)3.63070237
22macrophage activation (GO:0042116)3.56409268
23B cell receptor signaling pathway (GO:0050853)3.55322160
24regulation of gamma-delta T cell differentiation (GO:0045586)3.54116130
25growth hormone receptor signaling pathway (GO:0060396)3.47979829
26positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44312036
27nuclear pore complex assembly (GO:0051292)3.41045662
28respiratory burst (GO:0045730)3.38633421
29regulation of dendritic cell antigen processing and presentation (GO:0002604)3.38199672
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36965490
31regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.36585113
32regulation of B cell differentiation (GO:0045577)3.32188457
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.29504745
34dosage compensation (GO:0007549)3.26882269
35myeloid cell activation involved in immune response (GO:0002275)3.25746670
36neutrophil activation (GO:0042119)3.24171989
37negative regulation of erythrocyte differentiation (GO:0045647)3.23830505
38regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.22280903
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.19983214
40negative regulation of T cell mediated immunity (GO:0002710)3.18097549
41myeloid leukocyte mediated immunity (GO:0002444)3.16864983
42myoblast migration (GO:0051451)3.15312376
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15037101
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.15037101
45modulation by symbiont of host immune response (GO:0052553)3.15037101
46positive regulation by symbiont of host defense response (GO:0052509)3.15037101
47modulation by symbiont of host defense response (GO:0052031)3.15037101
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15037101
49regulation of mast cell degranulation (GO:0043304)3.13039325
50antigen processing and presentation of endogenous antigen (GO:0019883)3.12303361
51phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.10930350
52production of molecular mediator involved in inflammatory response (GO:0002532)3.10576872
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07364744
54immunoglobulin mediated immune response (GO:0016064)3.05894153
55granulocyte activation (GO:0036230)3.03353175
56histone H3-K36 demethylation (GO:0070544)3.03053960
57cell wall macromolecule catabolic process (GO:0016998)3.00772269
58negative regulation of cell aging (GO:0090344)2.97350350
59regulation of necroptotic process (GO:0060544)2.94530353
60interkinetic nuclear migration (GO:0022027)2.94221894
61leukocyte migration involved in inflammatory response (GO:0002523)2.93240021
62cellular response to growth hormone stimulus (GO:0071378)2.91783753
63lipopolysaccharide-mediated signaling pathway (GO:0031663)2.90234797
64regulation of mast cell activation involved in immune response (GO:0033006)2.89846133
65positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.88616171
66regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.86749945
67DNA synthesis involved in DNA repair (GO:0000731)2.86405860
68positive regulation of mast cell activation (GO:0033005)2.85097819
69sister chromatid cohesion (GO:0007062)2.85097536
70leukocyte aggregation (GO:0070486)2.83005108
71positive regulation of interleukin-1 beta secretion (GO:0050718)2.82395164
72regulation of myeloid leukocyte mediated immunity (GO:0002886)2.80136486
73regulation of leukocyte degranulation (GO:0043300)2.80085077
74positive regulation of mitotic sister chromatid separation (GO:1901970)2.78461918
75positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.78461918
76positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.78461918
77meiotic chromosome segregation (GO:0045132)2.78085009
78regulation of mast cell activation (GO:0033003)2.77918121
79B cell mediated immunity (GO:0019724)2.77452966
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.76784882
81negative regulation of leukocyte mediated immunity (GO:0002704)2.75718643
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75505015
83defense response to protozoan (GO:0042832)2.74598732
84I-kappaB phosphorylation (GO:0007252)2.73617693
85regulation of T-helper 2 cell differentiation (GO:0045628)2.73310018
86cell adhesion mediated by integrin (GO:0033627)2.72367095
87cell wall macromolecule metabolic process (GO:0044036)2.71758841
88positive regulation of cellular amide metabolic process (GO:0034250)2.70333682
89positive regulation of interferon-alpha production (GO:0032727)2.67423106
90hepatocyte apoptotic process (GO:0097284)2.67310102
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66830348
92striated muscle atrophy (GO:0014891)2.66619989
93response to interleukin-15 (GO:0070672)2.63792997
94T-helper 1 type immune response (GO:0042088)2.61554003
95protein K6-linked ubiquitination (GO:0085020)2.61291380
96positive regulation of toll-like receptor signaling pathway (GO:0034123)2.61054510
97histone lysine demethylation (GO:0070076)2.60929980
98positive regulation of interleukin-1 beta production (GO:0032731)2.59509959
99nuclear pore organization (GO:0006999)2.59044419
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.58969708
101positive regulation of interleukin-1 secretion (GO:0050716)2.58263226
102dendritic cell migration (GO:0036336)2.57275910
103skeletal muscle adaptation (GO:0043501)2.57191866
104regulation of interleukin-1 beta secretion (GO:0050706)2.56463907
105negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.56370260
106regulation of interferon-alpha production (GO:0032647)2.54852733
107positive regulation of interferon-beta production (GO:0032728)2.54001878
108negative regulation of B cell proliferation (GO:0030889)2.50676944
109histone demethylation (GO:0016577)2.50618083
110paraxial mesoderm development (GO:0048339)2.48424168
111pore complex assembly (GO:0046931)2.46363328
112ganglion development (GO:0061548)2.45941899
113regulation of tolerance induction (GO:0002643)2.45535633
114muscle atrophy (GO:0014889)2.44948964
115histone H3-K9 demethylation (GO:0033169)2.44923549
116NLS-bearing protein import into nucleus (GO:0006607)2.43286136
117cytokine secretion (GO:0050663)2.42370195
118neuron projection extension involved in neuron projection guidance (GO:1902284)2.39699549
119axon extension involved in axon guidance (GO:0048846)2.39699549
120superoxide anion generation (GO:0042554)2.39292038
121regulation of RNA export from nucleus (GO:0046831)2.37420174
122detection of other organism (GO:0098543)2.36694280
123fibroblast migration (GO:0010761)2.36656331
124positive regulation of interleukin-1 production (GO:0032732)2.35390806
125regulation of Cdc42 GTPase activity (GO:0043088)2.34415263
126peptidyl-lysine trimethylation (GO:0018023)2.33674799
127positive regulation of antigen processing and presentation (GO:0002579)2.32902937
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.32247708
129positive regulation of Cdc42 GTPase activity (GO:0043089)2.31228031
130regulation of keratinocyte proliferation (GO:0010837)2.31031469
131regulation of DNA endoreduplication (GO:0032875)2.28181815
132histone H3-K4 trimethylation (GO:0080182)2.27822113
133regulation of establishment of cell polarity (GO:2000114)2.27093227
134pericardium development (GO:0060039)2.27059489
135kidney morphogenesis (GO:0060993)2.26977720
136histone H3-K9 methylation (GO:0051567)2.26719871
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.25457462
138negative regulation of granulocyte differentiation (GO:0030853)2.25310131
139NIK/NF-kappaB signaling (GO:0038061)2.25061430
140positive regulation of heat generation (GO:0031652)2.24513909
141germinal center formation (GO:0002467)2.24346314
142regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.23774539
143positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.23092944
144regulation of protein polyubiquitination (GO:1902914)2.22451595
145response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.22154763
146response to host immune response (GO:0052572)2.22154763
147natural killer cell mediated immunity (GO:0002228)2.21632843
148natural killer cell mediated cytotoxicity (GO:0042267)2.21632843
149radial glial cell differentiation (GO:0060019)2.21030808
150modulation by symbiont of host cellular process (GO:0044068)2.20480941
151regulation of interleukin-1 secretion (GO:0050704)2.17917045
152negative regulation of translation, ncRNA-mediated (GO:0040033)2.17351937
153regulation of translation, ncRNA-mediated (GO:0045974)2.17351937
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.17351937
155kinetochore organization (GO:0051383)2.17118532
156response to muramyl dipeptide (GO:0032495)2.16864908
157mitotic chromosome condensation (GO:0007076)2.16825942
158response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.16749688
159response to host (GO:0075136)2.16749688
160response to host defenses (GO:0052200)2.16749688
161positive regulation of gamma-delta T cell activation (GO:0046645)2.16720421
162wound healing, spreading of epidermal cells (GO:0035313)2.15131226
163negative regulation of keratinocyte proliferation (GO:0010839)2.14108956
164regulation of integrin activation (GO:0033623)2.13954375
165cellular response to gamma radiation (GO:0071480)2.13156131
166positive regulation of interleukin-12 production (GO:0032735)2.12133374
167female gonad development (GO:0008585)2.11451338
168notochord development (GO:0030903)2.10860537
169regulation of histone H3-K9 methylation (GO:0051570)2.10042410
170nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.09228319
171regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.08691168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.34443247
2MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34246748
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.11646962
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.94494422
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.90802317
6SPI1_23547873_ChIP-Seq_NB4_Human2.75532495
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63860561
8SCL_19346495_ChIP-Seq_HPC-7_Human2.57747746
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.49875028
10GATA1_22025678_ChIP-Seq_K562_Human2.47521756
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.44620611
12MYB_26560356_Chip-Seq_TH2_Human2.31332385
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.24818725
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20899065
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.17083683
16RUNX_20019798_ChIP-Seq_JUKART_Human2.12728055
17SPI1_23127762_ChIP-Seq_K562_Human2.09541642
18MYB_26560356_Chip-Seq_TH1_Human2.09450902
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.09312341
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08427584
21IRF8_22096565_ChIP-ChIP_GC-B_Human2.08308086
22* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07942209
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.07852753
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.04026125
25E2F7_22180533_ChIP-Seq_HELA_Human2.00405885
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.00298075
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.00091440
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94964006
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.90800562
30* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.82017498
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.81507003
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.79736759
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78251167
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.77758634
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77057212
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76914602
37TP53_16413492_ChIP-PET_HCT116_Human1.75104517
38* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74395114
39* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.73371372
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71564416
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.67964977
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66810353
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.65791887
44* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63631476
45VDR_24763502_ChIP-Seq_THP-1_Human1.63630116
46* PU_27001747_Chip-Seq_BMDM_Mouse1.63355339
47GBX2_23144817_ChIP-Seq_PC3_Human1.63160330
48* NFE2_27457419_Chip-Seq_LIVER_Mouse1.62853928
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.60447562
50GATA3_27048872_Chip-Seq_THYMUS_Human1.59585922
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59208325
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58937151
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58709328
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58160751
55MYC_22102868_ChIP-Seq_BL_Human1.57589322
56* EZH2_27294783_Chip-Seq_NPCs_Mouse1.56993318
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56952826
58MAF_26560356_Chip-Seq_TH1_Human1.55452559
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55050853
60* NANOG_18555785_Chip-Seq_ESCs_Mouse1.54956449
61* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54554813
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54344565
63IRF8_21731497_ChIP-ChIP_J774_Mouse1.52011196
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51053513
65E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50103696
66FUS_26573619_Chip-Seq_HEK293_Human1.49453420
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.48937382
68TCF4_18268006_ChIP-ChIP_LS174T_Human1.47521828
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46446576
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45766748
71TFEB_21752829_ChIP-Seq_HELA_Human1.45638013
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42205660
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42171603
74* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42039797
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.41285714
76CJUN_26792858_Chip-Seq_BT549_Human1.39132519
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.38986803
78* E2F1_18555785_Chip-Seq_ESCs_Mouse1.36405122
79* BRD4_25478319_ChIP-Seq_HGPS_Human1.36388140
80VDR_24787735_ChIP-Seq_THP-1_Human1.34810951
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33160938
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33160938
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32803595
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.32437763
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31911050
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31573119
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30358100
88EWS_26573619_Chip-Seq_HEK293_Human1.30280014
89* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.30182698
90TCF7_22412390_ChIP-Seq_EML_Mouse1.30113655
91* P53_22387025_ChIP-Seq_ESCs_Mouse1.28941438
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.28323693
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27336779
94* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26559474
95* VDR_21846776_ChIP-Seq_THP-1_Human1.25475814
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.24521356
97SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22735025
98* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22558116
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.21885572
100* UTX_26944678_Chip-Seq_JUKART_Human1.21286173
101* CMYC_18555785_Chip-Seq_ESCs_Mouse1.20904098
102STAT3_23295773_ChIP-Seq_U87_Human1.20371712
103* OCT4_18555785_Chip-Seq_ESCs_Mouse1.19365767
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.19269022
105P300_19829295_ChIP-Seq_ESCs_Human1.19010788
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18944415
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16679188
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16554549
109RXR_22108803_ChIP-Seq_LS180_Human1.16417405
110* CDX2_22108803_ChIP-Seq_LS180_Human1.16324093
111* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16272493
112* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15110685
113NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14707044
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14707044
115AHR_22903824_ChIP-Seq_MCF-7_Human1.13848461
116SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13604605
117SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13604605
118PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13320964
119* ER_23166858_ChIP-Seq_MCF-7_Human1.13144147
120GATA3_26560356_Chip-Seq_TH2_Human1.12915933
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12771785
122GATA2_21666600_ChIP-Seq_HMVEC_Human1.11788704
123ELF1_17652178_ChIP-ChIP_JURKAT_Human1.11507096
124* P300_18555785_Chip-Seq_ESCs_Mouse1.11328170
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11011267
126* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11007385
127KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10792165
128* NMYC_18555785_Chip-Seq_ESCs_Mouse1.10297049
129* STAT3_18555785_Chip-Seq_ESCs_Mouse1.09659151
130* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09536353
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09475847
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08265424
133PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08103330
134GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07071446
135BCAT_22108803_ChIP-Seq_LS180_Human1.07005558
136* TCF4_23295773_ChIP-Seq_U87_Human1.06738311
137* SOX2_18555785_Chip-Seq_ESCs_Mouse1.06702871
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06073939
139GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05642018
140PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05019588
141* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04280690
142* PU1_27457419_Chip-Seq_LIVER_Mouse1.03593789
143NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03483685
144IGF1R_20145208_ChIP-Seq_DFB_Human1.03473687
145MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03202257
146* SMAD4_21799915_ChIP-Seq_A2780_Human1.02706253
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01425239
148SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01227780
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00567189
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00358857
151FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.97628829
152PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96863277
153E2F1_21310950_ChIP-Seq_MCF-7_Human0.96246054
154GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92730136
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92585601
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91193362
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90653549
158KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90653549
159KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90653549
160GATA2_19941826_ChIP-Seq_K562_Human0.89757627
161* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88175477
162* ETS1_22383799_ChIP-Seq_G1ME_Mouse0.87310430
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87141043
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85403306
165* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84984605
166KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.84420064
167MAF_26560356_Chip-Seq_TH2_Human0.83860239
168* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83553542
169MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.83514385
170SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80809621
171NCOR1_26117541_ChIP-Seq_K562_Human0.79922091
172LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.79698364

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.25626993
2MP0008260_abnormal_autophagy3.66272483
3MP0003724_increased_susceptibility_to3.63587119
4MP0003303_peritoneal_inflammation3.44683373
5MP0005451_abnormal_body_composition2.83207714
6MP0003436_decreased_susceptibility_to2.48963013
7MP0003136_yellow_coat_color2.34499227
8MP0002009_preneoplasia2.33436323
9MP0001800_abnormal_humoral_immune2.24250074
10MP0005670_abnormal_white_adipose2.20862939
11MP0010352_gastrointestinal_tract_polyps2.04648704
12MP0005464_abnormal_platelet_physiology2.03532818
13MP0005025_abnormal_response_to2.03531535
14MP0003183_abnormal_peptide_metabolism2.01280947
15MP0003705_abnormal_hypodermis_morpholog2.00167530
16MP0003221_abnormal_cardiomyocyte_apopto1.99639276
17MP0002452_abnormal_antigen_presenting1.95147195
18MP0002723_abnormal_immune_serum1.93350325
19MP0002420_abnormal_adaptive_immunity1.92698487
20MP0009785_altered_susceptibility_to1.91793635
21MP0003763_abnormal_thymus_physiology1.91516834
22MP0005000_abnormal_immune_tolerance1.91272436
23MP0001819_abnormal_immune_cell1.90624351
24MP0000465_gastrointestinal_hemorrhage1.90459915
25MP0005257_abnormal_intraocular_pressure1.84799343
26MP0001790_abnormal_immune_system1.84208290
27MP0005387_immune_system_phenotype1.84208290
28MP0003787_abnormal_imprinting1.82895917
29MP0000383_abnormal_hair_follicle1.81965848
30MP0003191_abnormal_cellular_cholesterol1.79638549
31MP0000566_synostosis1.78273485
32MP0008057_abnormal_DNA_replication1.77826177
33MP0002006_tumorigenesis1.73425153
34MP0002398_abnormal_bone_marrow1.73305799
35MP0002148_abnormal_hypersensitivity_rea1.72947323
36MP0010307_abnormal_tumor_latency1.71794647
37MP0005671_abnormal_response_to1.71159894
38MP0003656_abnormal_erythrocyte_physiolo1.70474014
39MP0005503_abnormal_tendon_morphology1.68772264
40MP0008438_abnormal_cutaneous_collagen1.67247298
41MP0001835_abnormal_antigen_presentation1.66558088
42MP0002877_abnormal_melanocyte_morpholog1.65740864
43MP0003172_abnormal_lysosome_physiology1.62526647
44MP0005248_abnormal_Harderian_gland1.61826246
45MP0006082_CNS_inflammation1.60260330
46MP0003300_gastrointestinal_ulcer1.58931724
47MP0002166_altered_tumor_susceptibility1.58196763
48MP0002254_reproductive_system_inflammat1.56691145
49MP0000716_abnormal_immune_system1.56142403
50MP0005058_abnormal_lysosome_morphology1.55119724
51MP0008004_abnormal_stomach_pH1.54838492
52MP0001346_abnormal_lacrimal_gland1.52782690
53MP0002405_respiratory_system_inflammati1.51581942
54MP0010678_abnormal_skin_adnexa1.48910488
55MP0003937_abnormal_limbs/digits/tail_de1.46656791
56MP0010155_abnormal_intestine_physiology1.46262224
57MP0005171_absent_coat_pigmentation1.45533585
58MP0000689_abnormal_spleen_morphology1.45409505
59MP0003828_pulmonary_edema1.43311177
60MP0002722_abnormal_immune_system1.43144356
61MP0000858_altered_metastatic_potential1.41462755
62MP0005076_abnormal_cell_differentiation1.41310528
63MP0000427_abnormal_hair_cycle1.39825271
64MP0002396_abnormal_hematopoietic_system1.39349266
65MP0005275_abnormal_skin_tensile1.37747232
66MP0001845_abnormal_inflammatory_respons1.36200889
67MP0002102_abnormal_ear_morphology1.32458824
68MP0000015_abnormal_ear_pigmentation1.32283355
69MP0005647_abnormal_sex_gland1.31060861
70MP0000733_abnormal_muscle_development1.30501438
71MP0002060_abnormal_skin_morphology1.30296076
72MP0002429_abnormal_blood_cell1.30090396
73MP0000767_abnormal_smooth_muscle1.28551609
74MP0005075_abnormal_melanosome_morpholog1.28363341
75MP0000703_abnormal_thymus_morphology1.27902306
76MP0003091_abnormal_cell_migration1.27695249
77MP0003045_fibrosis1.26587809
78MP0000371_diluted_coat_color1.25925803
79MP0003868_abnormal_feces_composition1.23181809
80MP0003453_abnormal_keratinocyte_physiol1.22234289
81MP0005408_hypopigmentation1.22137263
82MP0005367_renal/urinary_system_phenotyp1.18300320
83MP0000516_abnormal_urinary_system1.18300320
84MP0004883_abnormal_blood_vessel1.18272008
85MP0008007_abnormal_cellular_replicative1.15258738
86MP0002138_abnormal_hepatobiliary_system1.15183432
87MP0004381_abnormal_hair_follicle1.14850203
88MP0000372_irregular_coat_pigmentation1.14824166
89MP0000627_abnormal_mammary_gland1.13155218
90MP0003111_abnormal_nucleus_morphology1.12399852
91MP0004947_skin_inflammation1.09659609
92MP0001533_abnormal_skeleton_physiology1.09588193
93MP0006054_spinal_hemorrhage1.09551390
94MP0005666_abnormal_adipose_tissue1.09498705
95MP0004264_abnormal_extraembryonic_tissu1.07671105
96MP0008877_abnormal_DNA_methylation1.07565436
97MP0008469_abnormal_protein_level1.06863289
98MP0003806_abnormal_nucleotide_metabolis1.06078637
99MP0000432_abnormal_head_morphology1.05174603
100MP0010094_abnormal_chromosome_stability1.04974514
101MP0004185_abnormal_adipocyte_glucose1.04849432
102MP0000685_abnormal_immune_system1.03216390
103MP0003941_abnormal_skin_development1.02916200
104MP0003448_altered_tumor_morphology1.02799337
105MP0008058_abnormal_DNA_repair1.02422795
106MP0004808_abnormal_hematopoietic_stem1.02300696
107MP0002095_abnormal_skin_pigmentation1.01388720
108MP0009250_abnormal_appendicular_skeleto0.96711459
109MP0009384_cardiac_valve_regurgitation0.96606131
110MP0002277_abnormal_respiratory_mucosa0.95929033
111MP0001915_intracranial_hemorrhage0.95607015
112MP0002928_abnormal_bile_duct0.95419364
113MP0003890_abnormal_embryonic-extraembry0.94625268
114MP0002075_abnormal_coat/hair_pigmentati0.94341523
115MP0001853_heart_inflammation0.93164181
116MP0000490_abnormal_crypts_of0.92697460
117MP0003252_abnormal_bile_duct0.92486122
118MP0010234_abnormal_vibrissa_follicle0.92230812
119MP0001851_eye_inflammation0.90953774
120MP0002168_other_aberrant_phenotype0.89094971
121MP0009697_abnormal_copulation0.88001610
122MP0002109_abnormal_limb_morphology0.87923597
123MP0003566_abnormal_cell_adhesion0.87538483
124MP0009053_abnormal_anal_canal0.87352771
125MP0001958_emphysema0.87040918
126MP0002019_abnormal_tumor_incidence0.86938310
127MP0002938_white_spotting0.86777329
128MP0001186_pigmentation_phenotype0.86351613
129MP0002998_abnormal_bone_remodeling0.86327558
130MP0001299_abnormal_eye_distance/0.86256222
131MP0003866_abnormal_defecation0.85951089
132MP0001661_extended_life_span0.85366311
133MP0009278_abnormal_bone_marrow0.84460359
134MP0003935_abnormal_craniofacial_develop0.83834884
135MP0001545_abnormal_hematopoietic_system0.83485782
136MP0005397_hematopoietic_system_phenotyp0.83485782
137MP0002177_abnormal_outer_ear0.83443605
138MP0005174_abnormal_tail_pigmentation0.83422515
139MP0004510_myositis0.83071971
140MP0003755_abnormal_palate_morphology0.82543885
141MP0002419_abnormal_innate_immunity0.82198827
142MP0002132_abnormal_respiratory_system0.82124382
143MP0005164_abnormal_response_to0.82077940
144MP0005508_abnormal_skeleton_morphology0.81888477
145MP0009333_abnormal_splenocyte_physiolog0.81081978
146MP0000579_abnormal_nail_morphology0.81066700
147MP0005310_abnormal_salivary_gland0.80867678
148MP0000377_abnormal_hair_follicle0.80307460
149MP0009764_decreased_sensitivity_to0.80304834
150MP0005409_darkened_coat_color0.79793035
151MP0003077_abnormal_cell_cycle0.79775061
152MP0003567_abnormal_fetal_cardiomyocyte0.79332554
153MP0002098_abnormal_vibrissa_morphology0.79059067
154MP0005621_abnormal_cell_physiology0.79047429
155MP0004957_abnormal_blastocyst_morpholog0.78306568
156MP0000313_abnormal_cell_death0.71712354
157MP0005384_cellular_phenotype0.71291862
158MP0000604_amyloidosis0.69387503
159MP0006035_abnormal_mitochondrial_morpho0.68602381
160MP0009763_increased_sensitivity_to0.67877729
161MP0001730_embryonic_growth_arrest0.67875543

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)3.98520425
2Myositis (HP:0100614)3.98249758
3Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.91809168
4Prostate neoplasm (HP:0100787)3.88023611
5Chromsome breakage (HP:0040012)3.70017356
6Spontaneous hematomas (HP:0007420)3.64486298
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50436975
8Lip pit (HP:0100267)3.48292314
9Alopecia of scalp (HP:0002293)3.37987335
10Follicular hyperkeratosis (HP:0007502)3.20139031
11T lymphocytopenia (HP:0005403)3.17324447
12Abnormality of the fingertips (HP:0001211)3.13929890
13Gastrointestinal infarctions (HP:0005244)3.11954181
14Keratoconjunctivitis sicca (HP:0001097)3.10250394
15Chronic obstructive pulmonary disease (HP:0006510)3.01254081
16Obstructive lung disease (HP:0006536)3.01254081
17Abnormality of T cell number (HP:0011839)2.98719223
18Gingival bleeding (HP:0000225)2.94929592
19Subacute progressive viral hepatitis (HP:0006572)2.92245290
20Encephalitis (HP:0002383)2.89396368
21Hematochezia (HP:0002573)2.79343467
22Papillary thyroid carcinoma (HP:0002895)2.75180589
23Urticaria (HP:0001025)2.75136188
24Peritonitis (HP:0002586)2.74328470
25Meningitis (HP:0001287)2.73549547
26Agnosia (HP:0010524)2.72970924
27Viral hepatitis (HP:0006562)2.72250797
28Absent frontal sinuses (HP:0002688)2.70750174
29Cellulitis (HP:0100658)2.68887679
30Stomatitis (HP:0010280)2.68776616
31Ectopic kidney (HP:0000086)2.68093829
32Abnormal delayed hypersensitivity skin test (HP:0002963)2.67931232
33Inflammation of the large intestine (HP:0002037)2.66284925
34Elevated erythrocyte sedimentation rate (HP:0003565)2.65527851
35Disinhibition (HP:0000734)2.63418671
36Gastrointestinal inflammation (HP:0004386)2.59422667
37IgM deficiency (HP:0002850)2.54567192
38Colitis (HP:0002583)2.53869971
39Syringomyelia (HP:0003396)2.52978503
40Spinal cord lesions (HP:0100561)2.52978503
41Vasculitis (HP:0002633)2.52295398
42Recurrent viral infections (HP:0004429)2.46633631
43Abnormality of the columella (HP:0009929)2.41826379
44Urethral obstruction (HP:0000796)2.39278008
45Aplasia cutis congenita (HP:0001057)2.38152616
46Acute myeloid leukemia (HP:0004808)2.35857235
47Abnormality of the nasal septum (HP:0000419)2.34497272
48Abnormality of incisor morphology (HP:0011063)2.31846517
49Amaurosis fugax (HP:0100576)2.30761340
50Slow saccadic eye movements (HP:0000514)2.29909527
51Neoplasm of the tracheobronchial system (HP:0100552)2.28250316
52Eczematoid dermatitis (HP:0000976)2.27751413
53Abnormality of the vasculature of the conjunctiva (HP:0008054)2.25917864
54Prolonged bleeding time (HP:0003010)2.25775227
55Short 4th metacarpal (HP:0010044)2.25176213
56Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25176213
57Chest pain (HP:0100749)2.24014984
58Abnormality of the peritoneum (HP:0002585)2.22444951
59Midline defect of the nose (HP:0004122)2.20613087
60Submucous cleft hard palate (HP:0000176)2.20399916
61Volvulus (HP:0002580)2.19823265
62Recurrent bacterial skin infections (HP:0005406)2.19426406
63Chronic hepatic failure (HP:0100626)2.19026024
64Pulmonary embolism (HP:0002204)2.17932755
65Ectropion (HP:0000656)2.17574017
66Hemoptysis (HP:0002105)2.17506826
67Epistaxis (HP:0000421)2.13903624
68Bell-shaped thorax (HP:0001591)2.13472763
69Periodontitis (HP:0000704)2.11215997
70Hypochromic microcytic anemia (HP:0004840)2.11187965
71Amyloidosis (HP:0011034)2.10829943
72Thickened calvaria (HP:0002684)2.10736077
73Hypoplastic ischia (HP:0003175)2.10530590
74Optic neuritis (HP:0100653)2.09138328
75Retrobulbar optic neuritis (HP:0100654)2.09138328
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.07506320
77Osteolytic defects of the hand bones (HP:0009699)2.07506320
78Anorexia (HP:0002039)2.07447544
79Curly hair (HP:0002212)2.06701426
80Thyroid carcinoma (HP:0002890)2.06135678
81Leukocytosis (HP:0001974)2.03927673
82Micronodular cirrhosis (HP:0001413)2.02550968
83Gangrene (HP:0100758)2.01226429
84Abnormality of the hepatic vasculature (HP:0006707)2.01219589
85Short middle phalanx of the 5th finger (HP:0004220)2.01196835
86Myocardial infarction (HP:0001658)2.00791637
87Microcytic anemia (HP:0001935)1.99833564
88Abnormality of T cells (HP:0002843)1.98233209
89Thick nail (HP:0001805)1.97374400
90Biliary tract neoplasm (HP:0100574)1.96948447
91Loss of speech (HP:0002371)1.96466209
92Narrow palate (HP:0000189)1.95360311
93Gastrointestinal carcinoma (HP:0002672)1.95168413
94Malignant gastrointestinal tract tumors (HP:0006749)1.95168413
95Recurrent abscess formation (HP:0002722)1.94018799
96Leiomyosarcoma (HP:0100243)1.92739970
97Uterine leiomyosarcoma (HP:0002891)1.92739970
98Recurrent cutaneous fungal infections (HP:0011370)1.92394991
99Chronic mucocutaneous candidiasis (HP:0002728)1.92394991
100Pulmonary infiltrates (HP:0002113)1.91723482
101Abnormality of chromosome stability (HP:0003220)1.90773896
102Long eyelashes (HP:0000527)1.90516576
103Episodic fever (HP:0001954)1.89921166
104Degeneration of the lateral corticospinal tracts (HP:0002314)1.89887501
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89887501
106Medulloblastoma (HP:0002885)1.89506476
107Upper motor neuron abnormality (HP:0002127)1.89060498
108Increased number of teeth (HP:0011069)1.88562238
109Acute hepatic failure (HP:0006554)1.88365729
110Amyotrophic lateral sclerosis (HP:0007354)1.88184665
111Alveolar cell carcinoma (HP:0006519)1.87626547
112Blepharitis (HP:0000498)1.85571670
113Deep philtrum (HP:0002002)1.84671261
114Abnormality of the frontal sinuses (HP:0002687)1.84495666
115Abnormality of glycosphingolipid metabolism (HP:0004343)1.84198998
116Abnormality of glycolipid metabolism (HP:0010969)1.84198998
117Abnormality of liposaccharide metabolism (HP:0010968)1.84198998
118Premature loss of primary teeth (HP:0006323)1.83768960
119Bladder carcinoma (HP:0002862)1.83238103
120Bladder neoplasm (HP:0009725)1.83238103
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.83207284
122Hip dysplasia (HP:0001385)1.82709238
123Aplasia/Hypoplasia of the macula (HP:0008059)1.82645328
124Abnormality of the parietal bone (HP:0002696)1.81786722
125Autoimmune hemolytic anemia (HP:0001890)1.81587435
126Neoplasm of the small intestine (HP:0100833)1.81263469
127Abnormality of pyrimidine metabolism (HP:0004353)1.80551024
128Portal hypertension (HP:0001409)1.80104401
129Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79607130
130Arterial thrombosis (HP:0004420)1.78532850
131Aortic aneurysm (HP:0004942)1.76283139
132Clubbing of toes (HP:0100760)1.75381592
133Fair hair (HP:0002286)1.74907248
134Abnormality of the ischium (HP:0003174)1.74819621
135Conjunctival telangiectasia (HP:0000524)1.74756022
136Thoracic kyphosis (HP:0002942)1.74418409
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.73813629
138Hypoplasia of the fovea (HP:0007750)1.73813629
139Trigonocephaly (HP:0000243)1.73303745
140Recurrent fungal infections (HP:0002841)1.73171974
141Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72152604
142Abnormality of primary teeth (HP:0006481)1.71259735
143Gingivitis (HP:0000230)1.69771328
144Keratitis (HP:0000491)1.64879486
145Abnormality of the prostate (HP:0008775)1.64500401
146Hyperglycemia (HP:0003074)1.64253579
147Limited elbow extension (HP:0001377)1.63993367
148Orchitis (HP:0100796)1.62632871
149Genetic anticipation (HP:0003743)1.61918854
150Generalized hypopigmentation of hair (HP:0011358)1.61849191
151Mediastinal lymphadenopathy (HP:0100721)1.60610957
152Meckel diverticulum (HP:0002245)1.59723525
153Mitral valve prolapse (HP:0001634)1.58930926
154Microglossia (HP:0000171)1.58717812
155Natal tooth (HP:0000695)1.57634098
156Recurrent gram-negative bacterial infections (HP:0005420)1.57557624
157Keratoconjunctivitis (HP:0001096)1.55133443
158Increased connective tissue (HP:0009025)1.54914909
159Abnormality of the 4th metacarpal (HP:0010012)1.54561593
160Transitional cell carcinoma of the bladder (HP:0006740)1.53299508
161Cubitus valgus (HP:0002967)1.51477106
162Osteomyelitis (HP:0002754)1.51007393
163Aortic dissection (HP:0002647)1.50210122
164Recurrent skin infections (HP:0001581)1.47718207
165Enlarged penis (HP:0000040)1.47366055
166Shallow orbits (HP:0000586)1.46705599
167Hypoplastic labia majora (HP:0000059)1.45966054
168Facial hemangioma (HP:0000329)1.45178108
169Pulmonary artery stenosis (HP:0004415)1.43908150
170Truncal obesity (HP:0001956)1.43726714
171Spondylolisthesis (HP:0003302)1.43647881
172Abnormality of the distal phalanx of the thumb (HP:0009617)1.43571036
173Aplasia/Hypoplasia affecting the retina (HP:0008061)1.43450874
174Abnormality of the carotid arteries (HP:0005344)1.43366301
175Abnormality of the ileum (HP:0001549)1.43201156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.76569821
2LATS15.48277201
3MKNK13.42014881
4TNIK3.38143552
5MAP2K33.21044706
6BLK2.96866691
7STK32.52233149
8CSK2.45104866
9MAP3K142.43877162
10CDK122.38631394
11NUAK12.35686697
12STK38L2.33297463
13ACVR1B2.30184642
14MAP4K12.27349711
15FRK2.16109337
16FGR2.11484453
17FES1.92649816
18EPHA31.85567453
19ZAK1.85007424
20CDK191.84071392
21LATS21.81349561
22BTK1.78676920
23KSR21.73451769
24PIK3CA1.71456755
25NEK91.67961346
26MAP3K61.67248299
27MAP3K21.64250399
28IRAK31.57464389
29MATK1.56722212
30IRAK21.55069789
31CSF1R1.48055229
32MAP3K11.45556390
33GRK61.44225258
34CDK91.43272939
35CAMK1D1.41981014
36ZAP701.41848212
37IRAK41.41830607
38SYK1.41489604
39MAP3K121.38811376
40TAOK11.38579063
41TAOK31.38259764
42KSR11.38090351
43PIK3CG1.34896177
44DMPK1.30445053
45RIPK11.27841387
46SCYL21.27394655
47LYN1.21842206
48NLK1.21063240
49BRD41.19889320
50MAP3K31.19767354
51MAP3K101.16756161
52EIF2AK21.15109235
53JAK31.15099603
54NEK21.15008831
55MELK1.14233187
56PRPF4B1.13533886
57CHUK1.11121348
58JAK11.09307199
59RAF11.06747865
60TBK11.06555809
61SGK21.05119033
62PRKAA21.04660029
63SGK31.02000254
64ERBB41.01041402
65BMPR21.00450037
66FGFR30.97309312
67PLK40.96537130
68MAP3K130.96429634
69MAP2K40.96277000
70TYK20.95770770
71CDK60.95556031
72CAMK1G0.95488967
73MAP3K110.95472222
74IKBKB0.94539918
75STK40.93109113
76TXK0.91112542
77INSRR0.90628712
78AKT30.88484458
79CHEK20.87290467
80TTN0.87193879
81CDC70.86091318
82LCK0.85700173
83CDK30.84186136
84IKBKE0.82258471
85PKN20.79942524
86RIPK40.79088674
87ERN10.78982973
88PDGFRB0.76997302
89KIT0.74115528
90SRPK10.72697295
91EPHB20.67451007
92NEK60.66599206
93PTK60.66268080
94RPS6KB20.66134508
95MAP3K50.66015033
96TRPM70.64368449
97EGFR0.64205867
98SGK10.63991071
99DYRK30.63505381
100ITK0.62562121
101* ATM0.62532261
102STK240.62443385
103TGFBR20.61093173
104MARK20.60619817
105MAP2K70.58531586
106CLK10.58136761
107PBK0.57427122
108CDK40.56068420
109ERBB30.55732401
110EPHB10.55628227
111IRAK10.55091503
112TTK0.53843830
113BRAF0.53832926
114DYRK1B0.53057687
115ATR0.52683329
116PDK10.52568171
117PDK20.52451766
118LRRK20.52044460
119RPS6KA40.51930323
120PRKAA10.50153154
121ABL10.49757680
122SIK30.46743995
123JAK20.45189882
124FGFR20.44927877
125TNK20.43478405
126PLK20.43295468
127FER0.43219376
128MARK30.42061140
129STK380.41887286
130TAOK20.41072278
131STK110.40966695
132PIM10.40646108
133CHEK10.40626415
134AKT10.40528119
135WNK10.40226369
136YES10.40119693
137RET0.39879428
138PNCK0.39025509
139MAPK70.38805774
140TEC0.38326221
141STK100.38134837
142CDK80.37674590
143DDR20.37601554
144MTOR0.37358203
145AURKB0.36314549
146ERBB20.35808858
147FYN0.35688361
148MAPK140.35586541
149MAP3K80.34956463
150IGF1R0.33961243
151HCK0.32810386
152RPS6KB10.32691098
153OBSCN0.31875807
154PDPK10.31712131
155BCR0.31479553
156ALK0.29916070
157MAPK100.29626951

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.25488695
2NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10900282
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.96671993
4Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84513268
5Small cell lung cancer_Homo sapiens_hsa052221.82947324
6MicroRNAs in cancer_Homo sapiens_hsa052061.78195232
7Adherens junction_Homo sapiens_hsa045201.73348604
8Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67790657
9Pancreatic cancer_Homo sapiens_hsa052121.66219442
10Lysine degradation_Homo sapiens_hsa003101.63949717
11TNF signaling pathway_Homo sapiens_hsa046681.63501518
12Leishmaniasis_Homo sapiens_hsa051401.59372237
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58027274
14TGF-beta signaling pathway_Homo sapiens_hsa043501.57267218
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.56820153
16Herpes simplex infection_Homo sapiens_hsa051681.54397226
17Osteoclast differentiation_Homo sapiens_hsa043801.51464632
18Measles_Homo sapiens_hsa051621.49071352
19Fanconi anemia pathway_Homo sapiens_hsa034601.42861065
20T cell receptor signaling pathway_Homo sapiens_hsa046601.41325577
21Melanoma_Homo sapiens_hsa052181.41190251
22Influenza A_Homo sapiens_hsa051641.37768576
23Chronic myeloid leukemia_Homo sapiens_hsa052201.35933069
24Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30535290
25Systemic lupus erythematosus_Homo sapiens_hsa053221.27911925
26Circadian rhythm_Homo sapiens_hsa047101.27507719
27Renal cell carcinoma_Homo sapiens_hsa052111.27471912
28Prostate cancer_Homo sapiens_hsa052151.27256968
29Toxoplasmosis_Homo sapiens_hsa051451.25706450
30FoxO signaling pathway_Homo sapiens_hsa040681.25055181
31mTOR signaling pathway_Homo sapiens_hsa041501.22676476
32Hepatitis B_Homo sapiens_hsa051611.20395409
33Tuberculosis_Homo sapiens_hsa051521.15546816
34VEGF signaling pathway_Homo sapiens_hsa043701.14914017
35Dorso-ventral axis formation_Homo sapiens_hsa043201.14368960
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.14042535
37Prolactin signaling pathway_Homo sapiens_hsa049171.13375123
38* p53 signaling pathway_Homo sapiens_hsa041151.12954504
39ECM-receptor interaction_Homo sapiens_hsa045121.12345363
40Malaria_Homo sapiens_hsa051441.10835044
41Staphylococcus aureus infection_Homo sapiens_hsa051501.10079258
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09626027
43Thyroid cancer_Homo sapiens_hsa052161.07409193
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.07053279
45Salmonella infection_Homo sapiens_hsa051321.06941267
46Cell cycle_Homo sapiens_hsa041101.05917836
47Viral myocarditis_Homo sapiens_hsa054161.05614862
48Longevity regulating pathway - mammal_Homo sapiens_hsa042111.04904976
49Phagosome_Homo sapiens_hsa041451.03898783
50Sphingolipid signaling pathway_Homo sapiens_hsa040711.03620351
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02252462
52B cell receptor signaling pathway_Homo sapiens_hsa046621.01314464
53Jak-STAT signaling pathway_Homo sapiens_hsa046301.00771431
54Apoptosis_Homo sapiens_hsa042100.96323881
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95962440
56Hepatitis C_Homo sapiens_hsa051600.95856355
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.94233774
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93312996
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92535737
60Proteoglycans in cancer_Homo sapiens_hsa052050.92178221
61Antigen processing and presentation_Homo sapiens_hsa046120.92055493
62Focal adhesion_Homo sapiens_hsa045100.88451001
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86624683
64* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86476636
65Insulin resistance_Homo sapiens_hsa049310.86280201
66Inositol phosphate metabolism_Homo sapiens_hsa005620.84481782
67Lysosome_Homo sapiens_hsa041420.84037508
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.83741170
69Amoebiasis_Homo sapiens_hsa051460.83721045
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81984788
71Chemokine signaling pathway_Homo sapiens_hsa040620.81690472
72Autoimmune thyroid disease_Homo sapiens_hsa053200.81673438
73Type II diabetes mellitus_Homo sapiens_hsa049300.81632540
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81378683
75Ovarian steroidogenesis_Homo sapiens_hsa049130.80894097
76Endometrial cancer_Homo sapiens_hsa052130.80889409
77Acute myeloid leukemia_Homo sapiens_hsa052210.79529845
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79370875
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78890659
80Colorectal cancer_Homo sapiens_hsa052100.78280426
81Graft-versus-host disease_Homo sapiens_hsa053320.78114170
82Non-homologous end-joining_Homo sapiens_hsa034500.77279559
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76034711
84Pertussis_Homo sapiens_hsa051330.75493829
85Pathways in cancer_Homo sapiens_hsa052000.74442174
86African trypanosomiasis_Homo sapiens_hsa051430.74124546
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73924671
88Non-small cell lung cancer_Homo sapiens_hsa052230.73708331
89Legionellosis_Homo sapiens_hsa051340.72935948
90Type I diabetes mellitus_Homo sapiens_hsa049400.72121469
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71882034
92Epstein-Barr virus infection_Homo sapiens_hsa051690.71796975
93Viral carcinogenesis_Homo sapiens_hsa052030.71228600
94Asthma_Homo sapiens_hsa053100.68856655
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68027556
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66316332
97Choline metabolism in cancer_Homo sapiens_hsa052310.66034151
98Endocytosis_Homo sapiens_hsa041440.65478964
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.65403161
100HIF-1 signaling pathway_Homo sapiens_hsa040660.65217729
101Primary immunodeficiency_Homo sapiens_hsa053400.65201042
102Platelet activation_Homo sapiens_hsa046110.64997342
103Other glycan degradation_Homo sapiens_hsa005110.64464198
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.64074833
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61412205
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61271168
107MAPK signaling pathway_Homo sapiens_hsa040100.60943550
108HTLV-I infection_Homo sapiens_hsa051660.60827519
109Allograft rejection_Homo sapiens_hsa053300.60773873
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.60092547
111Hematopoietic cell lineage_Homo sapiens_hsa046400.60016416
112Basal cell carcinoma_Homo sapiens_hsa052170.59423833
113Notch signaling pathway_Homo sapiens_hsa043300.59309405
114Regulation of autophagy_Homo sapiens_hsa041400.58420452
115Dilated cardiomyopathy_Homo sapiens_hsa054140.58361049
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57746553
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57645500
118Glioma_Homo sapiens_hsa052140.57583391
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56296634
120Rheumatoid arthritis_Homo sapiens_hsa053230.54997831
121ErbB signaling pathway_Homo sapiens_hsa040120.53994191
122Bladder cancer_Homo sapiens_hsa052190.53050104
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.52895403
124Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52648003
125Insulin signaling pathway_Homo sapiens_hsa049100.50785093
126GnRH signaling pathway_Homo sapiens_hsa049120.49727907
127Vitamin digestion and absorption_Homo sapiens_hsa049770.49677253
128Hippo signaling pathway_Homo sapiens_hsa043900.49356711
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.48625661
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48406477
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47394030
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47293457
133Wnt signaling pathway_Homo sapiens_hsa043100.46888687
134Shigellosis_Homo sapiens_hsa051310.46641599

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