RFWD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.65834514
2nuclear pore complex assembly (GO:0051292)5.56898658
3DNA unwinding involved in DNA replication (GO:0006268)5.33931742
4protein localization to kinetochore (GO:0034501)5.33526192
5mitotic chromosome condensation (GO:0007076)4.82663026
6protein localization to chromosome, centromeric region (GO:0071459)4.54633570
7mitotic nuclear envelope disassembly (GO:0007077)4.53955653
8DNA replication-dependent nucleosome organization (GO:0034723)4.52590754
9DNA replication-dependent nucleosome assembly (GO:0006335)4.52590754
10DNA strand elongation involved in DNA replication (GO:0006271)4.32682585
11DNA replication initiation (GO:0006270)4.30249464
12mitotic sister chromatid segregation (GO:0000070)4.26734743
13membrane disassembly (GO:0030397)4.26575908
14nuclear envelope disassembly (GO:0051081)4.26575908
15sister chromatid segregation (GO:0000819)4.25706722
16establishment of integrated proviral latency (GO:0075713)4.21918257
17pore complex assembly (GO:0046931)4.21297843
18regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.17413928
19mitotic metaphase plate congression (GO:0007080)4.17117854
20DNA strand elongation (GO:0022616)4.08943286
21folic acid-containing compound biosynthetic process (GO:0009396)4.07484791
22mitotic sister chromatid cohesion (GO:0007064)4.01133627
23DNA duplex unwinding (GO:0032508)3.93484717
24DNA geometric change (GO:0032392)3.93156508
25regulation of histone H3-K9 methylation (GO:0051570)3.89057771
26positive regulation of chromosome segregation (GO:0051984)3.86747704
27attachment of spindle microtubules to kinetochore (GO:0008608)3.86089855
28DNA replication checkpoint (GO:0000076)3.85626419
29regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80307680
30regulation of spindle organization (GO:0090224)3.78785774
31telomere maintenance via semi-conservative replication (GO:0032201)3.75236478
32metaphase plate congression (GO:0051310)3.74621784
33regulation of sister chromatid cohesion (GO:0007063)3.70879019
34heterochromatin organization (GO:0070828)3.70193211
35nucleobase biosynthetic process (GO:0046112)3.68603320
36IMP biosynthetic process (GO:0006188)3.66845650
37negative regulation of histone methylation (GO:0031061)3.61573763
38translesion synthesis (GO:0019985)3.61372457
39mitotic recombination (GO:0006312)3.59120534
40pre-miRNA processing (GO:0031054)3.57393406
41chromatin assembly (GO:0031497)3.57150273
42protein complex localization (GO:0031503)3.52300330
43kinetochore organization (GO:0051383)3.51745040
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.50577829
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.50577829
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.50577829
47DNA ligation (GO:0006266)3.50122707
48regulation of chromosome segregation (GO:0051983)3.49821613
49telomere maintenance via recombination (GO:0000722)3.49551040
50regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48419242
51double-strand break repair via nonhomologous end joining (GO:0006303)3.47959923
52non-recombinational repair (GO:0000726)3.47959923
53protein localization to chromosome (GO:0034502)3.46234868
54chromatin remodeling at centromere (GO:0031055)3.45045650
55regulation of RNA export from nucleus (GO:0046831)3.43029651
56DNA synthesis involved in DNA repair (GO:0000731)3.43024306
57viral mRNA export from host cell nucleus (GO:0046784)3.41264734
58chromatin assembly or disassembly (GO:0006333)3.41081729
59nuclear envelope organization (GO:0006998)3.41040613
60dosage compensation (GO:0007549)3.40249699
61DNA replication-independent nucleosome organization (GO:0034724)3.39936171
62DNA replication-independent nucleosome assembly (GO:0006336)3.39936171
63meiotic chromosome segregation (GO:0045132)3.38863086
64DNA conformation change (GO:0071103)3.35638433
65chromosome condensation (GO:0030261)3.33703637
66regulation of mitotic spindle organization (GO:0060236)3.33002461
67CENP-A containing nucleosome assembly (GO:0034080)3.32222966
68establishment of chromosome localization (GO:0051303)3.31067223
69formation of translation preinitiation complex (GO:0001731)3.26766749
70spindle checkpoint (GO:0031577)3.26404684
71negative regulation of chromosome segregation (GO:0051985)3.25870476
72regulation of centrosome cycle (GO:0046605)3.25819914
73regulation of translational fidelity (GO:0006450)3.25775322
74IMP metabolic process (GO:0046040)3.24239169
75somatic diversification of immune receptors via somatic mutation (GO:0002566)3.23624917
76somatic hypermutation of immunoglobulin genes (GO:0016446)3.23624917
77regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23254913
78spindle assembly checkpoint (GO:0071173)3.22581489
79purine nucleobase biosynthetic process (GO:0009113)3.22128059
80postreplication repair (GO:0006301)3.21261407
81cellular protein complex localization (GO:0034629)3.19411753
82negative regulation of mRNA processing (GO:0050686)3.18353868
83negative regulation of sister chromatid segregation (GO:0033046)3.17537441
84negative regulation of mitotic sister chromatid separation (GO:2000816)3.17537441
85negative regulation of mitotic sister chromatid segregation (GO:0033048)3.17537441
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.17537441
87chromosome segregation (GO:0007059)3.17379806
88regulation of centriole replication (GO:0046599)3.16731585
89mitotic spindle assembly checkpoint (GO:0007094)3.16042491
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.15681484
91regulation of translational termination (GO:0006449)3.15633443
92mitotic spindle checkpoint (GO:0071174)3.13412616
93nucleotide-excision repair, DNA gap filling (GO:0006297)3.11838530
94telomere maintenance via telomere lengthening (GO:0010833)3.10651786
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10635608
96establishment of viral latency (GO:0019043)3.09315239
97ribosome assembly (GO:0042255)3.08697097
98histone exchange (GO:0043486)3.08528391
99negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07904694
100spliceosomal tri-snRNP complex assembly (GO:0000244)3.07074491
101regulation of mitotic sister chromatid separation (GO:0010965)3.06070412
102regulation of mitotic sister chromatid segregation (GO:0033047)3.06070412
103regulation of sister chromatid segregation (GO:0033045)3.06070412
104regulation of centrosome duplication (GO:0010824)3.04491143
105DNA packaging (GO:0006323)3.02613175
106regulation of gene silencing by RNA (GO:0060966)3.02163826
107regulation of posttranscriptional gene silencing (GO:0060147)3.02163826
108regulation of gene silencing by miRNA (GO:0060964)3.02163826
109histone H2A monoubiquitination (GO:0035518)3.00066465
110DNA topological change (GO:0006265)2.99633346
111telomere maintenance (GO:0000723)2.98884162
112protein K6-linked ubiquitination (GO:0085020)2.97803601
113ATP-dependent chromatin remodeling (GO:0043044)2.94498945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human5.46239001
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.09540107
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.44188198
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.39587788
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.10253338
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02211662
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59431748
8AR_21909140_ChIP-Seq_LNCAP_Human2.57836561
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.36037434
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.33318757
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33210612
12* E2F1_21310950_ChIP-Seq_MCF-7_Human2.32170942
13MYC_22102868_ChIP-Seq_BL_Human2.25418516
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.23793988
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01204892
16E2F7_22180533_ChIP-Seq_HELA_Human10.3322615
17* XRN2_22483619_ChIP-Seq_HELA_Human1.89087376
18* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87562558
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.85288758
20EST1_17652178_ChIP-ChIP_JURKAT_Human1.82230702
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82062486
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71461445
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69501793
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.68777385
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65981832
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65930738
27CIITA_25753668_ChIP-Seq_RAJI_Human1.60789661
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60668247
29VDR_23849224_ChIP-Seq_CD4+_Human1.56665720
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56044346
31KDM5A_27292631_Chip-Seq_BREAST_Human1.54271595
32SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53464131
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50258736
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.49337362
35SALL1_21062744_ChIP-ChIP_HESCs_Human1.48521442
36ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47992291
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.47965862
38* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46198558
39ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.43848109
40GABP_17652178_ChIP-ChIP_JURKAT_Human1.42926101
41DCP1A_22483619_ChIP-Seq_HELA_Human1.39391172
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37241447
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36005080
44GABP_19822575_ChIP-Seq_HepG2_Human1.35673759
45TTF2_22483619_ChIP-Seq_HELA_Human1.34284607
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34241549
47* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33638947
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32776682
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29253051
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.27751303
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.27151872
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26029803
53ELK1_19687146_ChIP-ChIP_HELA_Human1.25776812
54VDR_21846776_ChIP-Seq_THP-1_Human1.25648877
55TFEB_21752829_ChIP-Seq_HELA_Human1.24326470
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23494100
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22382265
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19748107
59* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16746826
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15711682
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15568367
62* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.14816055
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11506764
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.10969875
65KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10787702
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10787702
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10787702
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09888838
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09308360
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08537841
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.07906168
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05110368
73TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04665631
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02949655
75* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.02263243
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01427405
77ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99408482
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99262236
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98040204
80NOTCH1_21737748_ChIP-Seq_TLL_Human0.95851177
81ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95761288
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94899168
83CHD1_26751641_Chip-Seq_LNCaP_Human0.94008309
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93175440
85ZNF263_19887448_ChIP-Seq_K562_Human0.91859388
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91463712
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91284037
88TCF7_22412390_ChIP-Seq_EML_Mouse0.90716449
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89008640
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88647208
91SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88447956
92* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88180383
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.87309492
94KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87290803
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.86431292
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.84802627
97MYC_18940864_ChIP-ChIP_HL60_Human0.84774936
98PKCTHETA_26484144_Chip-Seq_BREAST_Human0.84254754
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.84111606
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83950235
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83922258
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.83875277
103UTX_26944678_Chip-Seq_JUKART_Human0.83221773
104MAF_26560356_Chip-Seq_TH1_Human0.82139389
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78598048
106SRF_21415370_ChIP-Seq_HL-1_Mouse0.78023306
107TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77865697
108NCOR1_26117541_ChIP-Seq_K562_Human0.77160856
109ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76965474
110MYB_26560356_Chip-Seq_TH1_Human0.76801022
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76347596
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.76202206
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.74717224

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.40963062
2MP0003693_abnormal_embryo_hatching4.15830927
3MP0003111_abnormal_nucleus_morphology4.09940367
4MP0004957_abnormal_blastocyst_morpholog3.72505228
5MP0003077_abnormal_cell_cycle3.59591618
6MP0008057_abnormal_DNA_replication3.56087425
7MP0010352_gastrointestinal_tract_polyps2.96436226
8MP0008877_abnormal_DNA_methylation2.93935931
9MP0010307_abnormal_tumor_latency2.71706879
10MP0001730_embryonic_growth_arrest2.54755214
11MP0008058_abnormal_DNA_repair2.49901858
12MP0003123_paternal_imprinting2.42639036
13MP0008007_abnormal_cellular_replicative2.35282338
14MP0005076_abnormal_cell_differentiation2.27806287
15MP0000350_abnormal_cell_proliferation2.27473795
16MP0003705_abnormal_hypodermis_morpholog2.07547034
17MP0002396_abnormal_hematopoietic_system2.02519003
18MP0008932_abnormal_embryonic_tissue2.01524305
19MP0001672_abnormal_embryogenesis/_devel1.94267097
20MP0005380_embryogenesis_phenotype1.94267097
21MP0002009_preneoplasia1.93810943
22MP0003786_premature_aging1.88432643
23MP0001697_abnormal_embryo_size1.79784274
24MP0003984_embryonic_growth_retardation1.78664132
25MP0004197_abnormal_fetal_growth/weight/1.77218035
26MP0002088_abnormal_embryonic_growth/wei1.75079868
27MP0002084_abnormal_developmental_patter1.71575491
28MP0004808_abnormal_hematopoietic_stem1.70100384
29MP0002086_abnormal_extraembryonic_tissu1.68772754
30MP0009697_abnormal_copulation1.66636982
31MP0002085_abnormal_embryonic_tissue1.64705613
32MP0002080_prenatal_lethality1.63364665
33MP0003121_genomic_imprinting1.59098634
34MP0009278_abnormal_bone_marrow1.52689467
35MP0003941_abnormal_skin_development1.49719719
36MP0000537_abnormal_urethra_morphology1.45757871
37MP0000490_abnormal_crypts_of1.43142354
38MP0003567_abnormal_fetal_cardiomyocyte1.40265426
39MP0002210_abnormal_sex_determination1.39858945
40MP0003890_abnormal_embryonic-extraembry1.37104283
41MP0002019_abnormal_tumor_incidence1.36142212
42MP0000313_abnormal_cell_death1.33486605
43MP0010234_abnormal_vibrissa_follicle1.27056680
44MP0001145_abnormal_male_reproductive1.23444911
45MP0008995_early_reproductive_senescence1.23419947
46MP0003566_abnormal_cell_adhesion1.21749240
47MP0001545_abnormal_hematopoietic_system1.19026981
48MP0005397_hematopoietic_system_phenotyp1.19026981
49MP0009053_abnormal_anal_canal1.18806738
50MP0010030_abnormal_orbit_morphology1.16818162
51MP0005501_abnormal_skin_physiology1.14941542
52MP0001661_extended_life_span1.14345837
53MP0001929_abnormal_gametogenesis1.12475333
54MP0002877_abnormal_melanocyte_morpholog1.10989583
55MP0001293_anophthalmia1.09986584
56MP0001915_intracranial_hemorrhage1.08110252
57MP0001849_ear_inflammation1.07358821
58MP0004264_abnormal_extraembryonic_tissu1.07270601
59MP0009672_abnormal_birth_weight1.06806226
60MP0001346_abnormal_lacrimal_gland1.06531619
61MP0006054_spinal_hemorrhage1.04650207
62MP0000653_abnormal_sex_gland1.04100110
63MP0002796_impaired_skin_barrier1.03969709
64MP0000703_abnormal_thymus_morphology1.03082057
65MP0003119_abnormal_digestive_system1.01515345
66MP0005023_abnormal_wound_healing0.97569844
67MP0009703_decreased_birth_body0.94704228
68MP0006035_abnormal_mitochondrial_morpho0.93106176
69MP0001286_abnormal_eye_development0.92133030
70MP0002398_abnormal_bone_marrow0.91454028
71MP0005621_abnormal_cell_physiology0.88126530
72MP0002722_abnormal_immune_system0.87249052
73MP0003300_gastrointestinal_ulcer0.86557728
74MP0003315_abnormal_perineum_morphology0.86182520
75MP0000428_abnormal_craniofacial_morphol0.86021786
76MP0002092_abnormal_eye_morphology0.85705337
77MP0003943_abnormal_hepatobiliary_system0.85347238
78MP0000733_abnormal_muscle_development0.84706042
79MP0009333_abnormal_splenocyte_physiolog0.84579179
80MP0005384_cellular_phenotype0.83881762
81MP0003718_maternal_effect0.83305008
82MP0000689_abnormal_spleen_morphology0.80893447
83MP0005451_abnormal_body_composition0.80733295
84MP0002653_abnormal_ependyma_morphology0.80397806
85MP0003878_abnormal_ear_physiology0.80119759
86MP0005377_hearing/vestibular/ear_phenot0.80119759
87MP0000569_abnormal_digit_pigmentation0.79517358
88MP0006292_abnormal_olfactory_placode0.78833602
89MP0002111_abnormal_tail_morphology0.78167786
90MP0003937_abnormal_limbs/digits/tail_de0.76520001
91MP0002006_tumorigenesis0.73632820
92MP0000579_abnormal_nail_morphology0.73437374
93MP0003763_abnormal_thymus_physiology0.73320099
94MP0002697_abnormal_eye_size0.72561394
95MP0001119_abnormal_female_reproductive0.72483400
96MP0002160_abnormal_reproductive_system0.72087573
97MP0002925_abnormal_cardiovascular_devel0.71751926
98MP0003115_abnormal_respiratory_system0.71391741
99MP0003221_abnormal_cardiomyocyte_apopto0.71139005
100MP0000358_abnormal_cell_content/0.68609583
101MP0000627_abnormal_mammary_gland0.67793970
102MP0000477_abnormal_intestine_morphology0.67326596
103MP0002429_abnormal_blood_cell0.66124055
104MP0005389_reproductive_system_phenotype0.65668556
105MP0003861_abnormal_nervous_system0.64999476
106MP0002098_abnormal_vibrissa_morphology0.64814617
107MP0004185_abnormal_adipocyte_glucose0.63897571
108MP0002060_abnormal_skin_morphology0.63640528
109MP0001881_abnormal_mammary_gland0.63218737
110MP0001216_abnormal_epidermal_layer0.62496301
111MP0001348_abnormal_lacrimal_gland0.62464002
112MP0005623_abnormal_meninges_morphology0.61672438
113MP0000858_altered_metastatic_potential0.61066124
114MP0003656_abnormal_erythrocyte_physiolo0.60770535
115MP0004233_abnormal_muscle_weight0.59643900
116MP0002163_abnormal_gland_morphology0.59528886
117MP0000432_abnormal_head_morphology0.59093781
118MP0003935_abnormal_craniofacial_develop0.57984920
119MP0010678_abnormal_skin_adnexa0.57435236
120MP0008770_decreased_survivor_rate0.56967844
121MP0003699_abnormal_female_reproductive0.56937446
122MP0000377_abnormal_hair_follicle0.56823284
123MP0003448_altered_tumor_morphology0.56809426
124MP0002166_altered_tumor_susceptibility0.56394004
125MP0003698_abnormal_male_reproductive0.55016411
126MP0000266_abnormal_heart_morphology0.54481727

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)4.06094622
2Chromsome breakage (HP:0040012)3.71899454
3Selective tooth agenesis (HP:0001592)3.45749180
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.36342033
5Birth length less than 3rd percentile (HP:0003561)3.33229284
6Medulloblastoma (HP:0002885)3.31459245
7Colon cancer (HP:0003003)3.22918210
8Abnormality of chromosome stability (HP:0003220)3.20766419
9Nephroblastoma (Wilms tumor) (HP:0002667)3.16877532
10Increased nuchal translucency (HP:0010880)3.00256749
11Abnormality of the astrocytes (HP:0100707)3.00074605
12Astrocytoma (HP:0009592)3.00074605
13Embryonal renal neoplasm (HP:0011794)2.94051479
14Proximal placement of thumb (HP:0009623)2.88279709
15Impulsivity (HP:0100710)2.87841969
16Deviation of the thumb (HP:0009603)2.85342339
17Volvulus (HP:0002580)2.79846972
18Rhabdomyosarcoma (HP:0002859)2.76008445
19Reticulocytopenia (HP:0001896)2.71906024
20Meckel diverticulum (HP:0002245)2.67402332
21Agnosia (HP:0010524)2.66992887
22Short 4th metacarpal (HP:0010044)2.66370642
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66370642
24Multiple enchondromatosis (HP:0005701)2.64671233
25Abnormality of cochlea (HP:0000375)2.63855466
26Basal cell carcinoma (HP:0002671)2.62164635
27Ectopic kidney (HP:0000086)2.61237306
28Glioma (HP:0009733)2.60860425
29Patellar aplasia (HP:0006443)2.59241062
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.58821616
31Breast hypoplasia (HP:0003187)2.56459826
32Abnormality of the preputium (HP:0100587)2.51401341
33Abnormality of the ileum (HP:0001549)2.51039529
34Poikiloderma (HP:0001029)2.50779215
3511 pairs of ribs (HP:0000878)2.50670491
36Biliary tract neoplasm (HP:0100574)2.49303280
37Abnormality of the labia minora (HP:0012880)2.48365169
38Progressive muscle weakness (HP:0003323)2.47977414
39Myelodysplasia (HP:0002863)2.46440555
40Prominent nose (HP:0000448)2.45823379
41Aplasia/Hypoplasia of the patella (HP:0006498)2.42034821
42Microvesicular hepatic steatosis (HP:0001414)2.41943887
43Missing ribs (HP:0000921)2.41704924
44Duodenal stenosis (HP:0100867)2.41534129
45Small intestinal stenosis (HP:0012848)2.41534129
46Cortical dysplasia (HP:0002539)2.38827478
47High pitched voice (HP:0001620)2.38162487
48Cafe-au-lait spot (HP:0000957)2.37035329
49Degeneration of anterior horn cells (HP:0002398)2.36770693
50Abnormality of the anterior horn cell (HP:0006802)2.36770693
51Neoplasm of striated muscle (HP:0009728)2.33857791
52Neoplasm of the oral cavity (HP:0100649)2.32263061
53Abnormality of the carotid arteries (HP:0005344)2.30897056
54Ankyloglossia (HP:0010296)2.29267057
55Absent thumb (HP:0009777)2.25649999
56Horseshoe kidney (HP:0000085)2.23559948
57Aplasia/Hypoplasia of the sacrum (HP:0008517)2.22384663
58Neoplasm of the pancreas (HP:0002894)2.21763073
59Septate vagina (HP:0001153)2.21475768
60Choanal atresia (HP:0000453)2.17070050
61Gastrointestinal carcinoma (HP:0002672)2.16805508
62Malignant gastrointestinal tract tumors (HP:0006749)2.16805508
63Abnormality of the fingertips (HP:0001211)2.16760526
64Ovarian neoplasm (HP:0100615)2.15837973
65Absent radius (HP:0003974)2.15570770
66Duplicated collecting system (HP:0000081)2.14647654
67Hyperacusis (HP:0010780)2.14369247
68Progressive external ophthalmoplegia (HP:0000590)2.11308652
69Sloping forehead (HP:0000340)2.10421142
70Facial hemangioma (HP:0000329)2.09410716
71Ankle contracture (HP:0006466)2.08776841
72Metaphyseal cupping (HP:0003021)2.08222651
73Cutaneous melanoma (HP:0012056)2.07861257
74Sandal gap (HP:0001852)2.07664073
75High anterior hairline (HP:0009890)2.05253500
76Abnormality of the calcaneus (HP:0008364)2.05003964
77Clubbing of toes (HP:0100760)2.02412573
78Squamous cell carcinoma (HP:0002860)2.01816450
79Insomnia (HP:0100785)2.01045429
80Embryonal neoplasm (HP:0002898)2.00923451
81Duplication of thumb phalanx (HP:0009942)2.00136908
82Abnormality of oral frenula (HP:0000190)1.99127138
83Atresia of the external auditory canal (HP:0000413)1.98517365
84Abnormality of the duodenum (HP:0002246)1.98198929
85Absent forearm bone (HP:0003953)1.96091281
86Aplasia involving forearm bones (HP:0009822)1.96091281
87Abnormal number of incisors (HP:0011064)1.95893929
88Long eyelashes (HP:0000527)1.95113673
89Triphalangeal thumb (HP:0001199)1.94521940
90Abnormality of the 4th metacarpal (HP:0010012)1.94154001
91Abnormality of chromosome segregation (HP:0002916)1.93668949
92Overriding aorta (HP:0002623)1.93657419
93Amaurosis fugax (HP:0100576)1.92655219
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.91787937
95Abnormal lung lobation (HP:0002101)1.91375317
96Arteriovenous malformation (HP:0100026)1.90281858
97Renal duplication (HP:0000075)1.87813917
98Oral leukoplakia (HP:0002745)1.87581553
99Tracheoesophageal fistula (HP:0002575)1.87295879
100Carpal bone hypoplasia (HP:0001498)1.84340307
101Asymmetry of the thorax (HP:0001555)1.84250058
102Acute myeloid leukemia (HP:0004808)1.84072835
103Entropion (HP:0000621)1.83142662
104Pelvic girdle muscle weakness (HP:0003749)1.81163858
105Neoplasm of the colon (HP:0100273)1.80676499
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.80078934
107Bone marrow hypocellularity (HP:0005528)1.79934015
108Heterotopia (HP:0002282)1.79400641
109Facial cleft (HP:0002006)1.77809025
110Urethral obstruction (HP:0000796)1.77254165
111Morphological abnormality of the inner ear (HP:0011390)1.76222682
112Elfin facies (HP:0004428)1.75397657
113Pseudobulbar signs (HP:0002200)1.74807259
114Overlapping toe (HP:0001845)1.74545599
115Acute lymphatic leukemia (HP:0006721)1.74429926
116Trismus (HP:0000211)1.74407954
117Renovascular hypertension (HP:0100817)1.74082718
118Skull defect (HP:0001362)1.72775705
119Abnormality of reticulocytes (HP:0004312)1.72583941
120Broad distal phalanx of finger (HP:0009836)1.72438989
121Spastic diplegia (HP:0001264)1.71444335
122Short thumb (HP:0009778)1.71229028
123Microglossia (HP:0000171)1.70970573
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70634124
125Intestinal polyp (HP:0005266)1.70309754
126Deep philtrum (HP:0002002)1.69934150
127Abnormality of DNA repair (HP:0003254)1.69634455
128Capillary hemangiomas (HP:0005306)1.69469988
129Rectal prolapse (HP:0002035)1.68948697
130Cutis marmorata (HP:0000965)1.68460280
131Uterine leiomyosarcoma (HP:0002891)1.68317830
132Leiomyosarcoma (HP:0100243)1.68317830
133Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68149149
134Abnormal biliary tract morphology (HP:0012440)1.67504417
135Hand muscle atrophy (HP:0009130)1.67480571
136Skin tags (HP:0010609)1.67408107
137Low anterior hairline (HP:0000294)1.67312282
138Abnormality of the renal collecting system (HP:0004742)1.67084698
139Thrombocytosis (HP:0001894)1.66548919
140Aplasia/hypoplasia of the humerus (HP:0006507)1.66116842
141Premature ovarian failure (HP:0008209)1.65278397
142Abnormal spermatogenesis (HP:0008669)1.64843754
143Intestinal polyposis (HP:0200008)1.64527411
144Obsessive-compulsive behavior (HP:0000722)1.64441549
145Orthostatic hypotension (HP:0001278)1.64082731
146Ureteral duplication (HP:0000073)1.63261348

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.81982366
2CDK123.75078402
3WEE13.48197895
4NEK23.46134697
5EEF2K2.93023215
6BUB12.92308549
7SMG12.85963030
8TTK2.42500939
9PBK2.33510458
10NEK12.22752701
11PKN22.06319391
12MAP3K102.03769657
13TSSK61.92448540
14RPS6KB21.86349580
15PASK1.85296976
16ACVR1B1.83349662
17CDK41.81582124
18PLK11.78377378
19STK101.77005740
20ATR1.74133356
21CDK71.70612318
22BRSK21.60689829
23AURKB1.60452106
24VRK21.59499737
25BRD41.57007109
26EIF2AK11.56128592
27TRIB31.55171049
28CDK81.54474245
29SRPK11.53121727
30STK41.52631337
31TAF11.51794276
32SCYL21.51387333
33MAP3K81.48679419
34PLK41.43019910
35CHEK11.41204494
36CHEK21.40355366
37CDK61.39561128
38STK31.37349207
39RPS6KA41.35457744
40EPHA21.34010774
41PLK31.32136063
42MKNK11.18469080
43LATS11.15433665
44PAK41.14919254
45DYRK31.11070458
46ALK1.08680021
47TGFBR11.08250249
48TLK11.04425618
49IRAK31.03763005
50* ATM1.03199225
51BRSK10.98794558
52LRRK20.98496283
53MTOR0.98485807
54MELK0.98028273
55CDK20.97057948
56TESK20.96854372
57FLT30.95849506
58PIM10.90277141
59EIF2AK20.86471527
60PTK60.84673856
61AURKA0.84132632
62TTN0.83042543
63ZAK0.81879249
64CDK90.81868558
65KSR20.79837260
66MKNK20.78745392
67MAP4K10.77531204
68RAF10.74659604
69CDK10.72887310
70ICK0.72378187
71CAMK1G0.68511963
72RIPK10.68252128
73MST1R0.65213426
74ERBB40.61331838
75BRAF0.59974488
76EIF2AK30.59789343
77VRK10.58593655
78MAP2K30.57756737
79FGFR10.56851120
80TESK10.56735375
81PDGFRA0.56144626
82MST40.55061507
83CCNB10.54685143
84PRPF4B0.52337316
85PNCK0.51471139
86FGFR40.50611858
87PAK20.49928044
88PAK10.49720746
89GRK60.48513452
90CSNK2A20.48450897
91BMX0.48387979
92CSNK1D0.47281989
93CAMK1D0.46706476
94PRKDC0.46264911
95MAPKAPK30.45623698
96NME10.45143989
97PDK40.44644860
98PDK30.44644860
99NUAK10.44328890
100MAP2K20.42982363
101CLK10.42715922
102MAP3K90.40618101
103LATS20.40504355
104TYRO30.40312069
105MAPK140.37857207
106CSNK1E0.37839624
107AKT20.37038260
108RPS6KA50.36863325
109MARK30.36478382
110JAK30.34167806
111CSNK2A10.33342552
112STK38L0.31170433
113MAP3K140.30988350
114MAPK10.30952852
115CHUK0.30478118
116BTK0.30340374
117AKT10.30314568
118MET0.29864495
119CSF1R0.29091730
120NME20.28983979
121KSR10.28943089
122RPS6KA10.28566738
123MAPK110.28287401
124PDK20.27466228
125GSK3B0.27340985
126PRKCI0.26582193
127NEK90.25811581
128RPS6KB10.23738333
129CDK30.22611669

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79624002
2Mismatch repair_Homo sapiens_hsa034304.18156225
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.31554227
4RNA transport_Homo sapiens_hsa030133.24247333
5Cell cycle_Homo sapiens_hsa041103.20503495
6Spliceosome_Homo sapiens_hsa030402.95382050
7One carbon pool by folate_Homo sapiens_hsa006702.92735686
8Base excision repair_Homo sapiens_hsa034102.86521217
9Homologous recombination_Homo sapiens_hsa034402.67066481
10Nucleotide excision repair_Homo sapiens_hsa034202.59998805
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.33630717
12Fanconi anemia pathway_Homo sapiens_hsa034602.22168720
13mRNA surveillance pathway_Homo sapiens_hsa030152.15593738
14Non-homologous end-joining_Homo sapiens_hsa034502.15047626
15Systemic lupus erythematosus_Homo sapiens_hsa053221.91240210
16p53 signaling pathway_Homo sapiens_hsa041151.75963948
17RNA polymerase_Homo sapiens_hsa030201.72426984
18RNA degradation_Homo sapiens_hsa030181.68605531
19Pyrimidine metabolism_Homo sapiens_hsa002401.52588480
20Viral carcinogenesis_Homo sapiens_hsa052031.52244894
21Basal transcription factors_Homo sapiens_hsa030221.49267108
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.39829014
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35121079
24Ribosome_Homo sapiens_hsa030101.34573144
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.33885755
26Antigen processing and presentation_Homo sapiens_hsa046121.33636918
27Proteasome_Homo sapiens_hsa030501.28675329
28Oocyte meiosis_Homo sapiens_hsa041141.21836080
29Small cell lung cancer_Homo sapiens_hsa052221.21278375
30Selenocompound metabolism_Homo sapiens_hsa004501.19657356
31Epstein-Barr virus infection_Homo sapiens_hsa051691.18401744
32Herpes simplex infection_Homo sapiens_hsa051681.13291215
33MicroRNAs in cancer_Homo sapiens_hsa052061.11948397
34HTLV-I infection_Homo sapiens_hsa051661.07087436
35Biosynthesis of amino acids_Homo sapiens_hsa012301.00465295
36Lysine degradation_Homo sapiens_hsa003100.92258194
37Chronic myeloid leukemia_Homo sapiens_hsa052200.87047622
38Pentose phosphate pathway_Homo sapiens_hsa000300.84877158
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84735551
40Thyroid cancer_Homo sapiens_hsa052160.82748929
41Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80747134
42Alcoholism_Homo sapiens_hsa050340.77103224
43Adherens junction_Homo sapiens_hsa045200.76282066
44Colorectal cancer_Homo sapiens_hsa052100.75732281
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.75069088
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74088795
47mTOR signaling pathway_Homo sapiens_hsa041500.73745499
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72460974
49TGF-beta signaling pathway_Homo sapiens_hsa043500.72327963
50Hippo signaling pathway_Homo sapiens_hsa043900.72273972
51Pyruvate metabolism_Homo sapiens_hsa006200.72124996
52Legionellosis_Homo sapiens_hsa051340.70656267
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.70542344
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70177751
55Vitamin B6 metabolism_Homo sapiens_hsa007500.66833194
56Purine metabolism_Homo sapiens_hsa002300.66068139
57Notch signaling pathway_Homo sapiens_hsa043300.65934921
58Apoptosis_Homo sapiens_hsa042100.65002123
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64224971
60Hepatitis B_Homo sapiens_hsa051610.63520738
61Steroid biosynthesis_Homo sapiens_hsa001000.61698741
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60985013
63Non-small cell lung cancer_Homo sapiens_hsa052230.59360067
64Viral myocarditis_Homo sapiens_hsa054160.56490356
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.55936761
66Sulfur relay system_Homo sapiens_hsa041220.55834362
67Pancreatic cancer_Homo sapiens_hsa052120.55411940
68Prostate cancer_Homo sapiens_hsa052150.55324469
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55086035
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.52480648
71Basal cell carcinoma_Homo sapiens_hsa052170.52256149
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51577836
73Primary immunodeficiency_Homo sapiens_hsa053400.50476722
74Carbon metabolism_Homo sapiens_hsa012000.49840269
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49126631
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47732749
77Proteoglycans in cancer_Homo sapiens_hsa052050.47603875
782-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46877364
79Bladder cancer_Homo sapiens_hsa052190.45942277
80Fructose and mannose metabolism_Homo sapiens_hsa000510.45763886
81Melanoma_Homo sapiens_hsa052180.45144300
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45059917
83Pathways in cancer_Homo sapiens_hsa052000.44782807
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.44431692
85Influenza A_Homo sapiens_hsa051640.44055545
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43473350
87Measles_Homo sapiens_hsa051620.43301202
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.42239040
89Glioma_Homo sapiens_hsa052140.42039509
90HIF-1 signaling pathway_Homo sapiens_hsa040660.41409707
91Shigellosis_Homo sapiens_hsa051310.39493698
92Endometrial cancer_Homo sapiens_hsa052130.39270855
93Wnt signaling pathway_Homo sapiens_hsa043100.37672046
94Acute myeloid leukemia_Homo sapiens_hsa052210.37293379
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35223008
96Toxoplasmosis_Homo sapiens_hsa051450.35197169
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35146513
98Folate biosynthesis_Homo sapiens_hsa007900.35038764
99Hedgehog signaling pathway_Homo sapiens_hsa043400.34220763
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34157996
101B cell receptor signaling pathway_Homo sapiens_hsa046620.33905556
102FoxO signaling pathway_Homo sapiens_hsa040680.32953734
103Tight junction_Homo sapiens_hsa045300.32182844
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30420653
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29110655
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27019123
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.26929280
108N-Glycan biosynthesis_Homo sapiens_hsa005100.26248573
109Galactose metabolism_Homo sapiens_hsa000520.26159210
110ErbB signaling pathway_Homo sapiens_hsa040120.25830918
111Renal cell carcinoma_Homo sapiens_hsa052110.23224344
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.23180057
113AMPK signaling pathway_Homo sapiens_hsa041520.23022040
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.22992466
115Focal adhesion_Homo sapiens_hsa045100.21126263
116Renin-angiotensin system_Homo sapiens_hsa046140.20202238
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17511752
118Leishmaniasis_Homo sapiens_hsa051400.16999270
119T cell receptor signaling pathway_Homo sapiens_hsa046600.16939916
120Protein export_Homo sapiens_hsa030600.14709190
121Insulin signaling pathway_Homo sapiens_hsa049100.14429327
122Glutathione metabolism_Homo sapiens_hsa004800.13839389
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13544034

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