RFX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive thymic T cell selection (GO:0045059)5.35573602
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.15943178
3positive regulation of gamma-delta T cell activation (GO:0046645)4.89425312
4positive T cell selection (GO:0043368)4.77612767
5thymic T cell selection (GO:0045061)4.45465570
6negative regulation of cell killing (GO:0031342)4.45018854
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.45018854
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.32299083
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.32299083
10modulation by symbiont of host immune response (GO:0052553)4.32299083
11positive regulation by symbiont of host defense response (GO:0052509)4.32299083
12modulation by symbiont of host defense response (GO:0052031)4.32299083
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.32299083
14regulation of gamma-delta T cell differentiation (GO:0045586)4.30777245
15T cell selection (GO:0045058)4.15889960
16regulation of gamma-delta T cell activation (GO:0046643)4.13006782
17negative thymic T cell selection (GO:0045060)4.12595081
18negative T cell selection (GO:0043383)4.11889872
19pyrimidine nucleoside salvage (GO:0043097)3.72175335
20pyrimidine-containing compound salvage (GO:0008655)3.72175335
21interferon-gamma production (GO:0032609)3.71494475
22histone H3-K4 trimethylation (GO:0080182)3.63779910
23negative regulation of phagocytosis (GO:0050765)3.62718202
24intracellular estrogen receptor signaling pathway (GO:0030520)3.60192453
25response to interleukin-15 (GO:0070672)3.58973673
26detection of bacterium (GO:0016045)3.56533208
27cell-cell junction maintenance (GO:0045217)3.55900317
28tolerance induction (GO:0002507)3.53993998
29pre-miRNA processing (GO:0031054)3.50099268
30response to peptidoglycan (GO:0032494)3.49897184
31neutrophil mediated immunity (GO:0002446)3.46243943
32detection of other organism (GO:0098543)3.46056928
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.45913742
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.43197417
35regulation of granulocyte differentiation (GO:0030852)3.43131184
36regulation of NFAT protein import into nucleus (GO:0051532)3.41692887
37histone H3-K4 methylation (GO:0051568)3.34705553
38RNA destabilization (GO:0050779)3.32517020
39macrophage activation involved in immune response (GO:0002281)3.29911291
40regulation of ARF GTPase activity (GO:0032312)3.28075433
41regulation of interleukin-12 biosynthetic process (GO:0045075)3.27356151
42retinoic acid receptor signaling pathway (GO:0048384)3.26571676
43response to host immune response (GO:0052572)3.25258237
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25258237
45epithelial cell fate commitment (GO:0072148)3.21614185
46immunoglobulin mediated immune response (GO:0016064)3.16721127
47positive regulation of histone deacetylation (GO:0031065)3.15476324
48NLS-bearing protein import into nucleus (GO:0006607)3.14113190
49neutrophil activation involved in immune response (GO:0002283)3.12629467
50neutrophil activation (GO:0042119)3.11905388
51regulation of interferon-beta biosynthetic process (GO:0045357)3.10094496
52regulation of B cell receptor signaling pathway (GO:0050855)3.07769072
53negative regulation of DNA-templated transcription, elongation (GO:0032785)3.06152418
54cellular response to interleukin-15 (GO:0071350)3.03633641
55protein polyglutamylation (GO:0018095)3.03348181
56negative regulation of histone methylation (GO:0031061)3.02857323
57histone H4 deacetylation (GO:0070933)3.01940074
58nucleosome disassembly (GO:0006337)3.01409211
59protein-DNA complex disassembly (GO:0032986)3.01409211
60regulation of chromatin binding (GO:0035561)2.98200382
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.94388988
62response to host (GO:0075136)2.94388988
63response to host defenses (GO:0052200)2.94388988
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94170083
65antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.94170083
66respiratory burst (GO:0045730)2.93960102
67histone H4-K12 acetylation (GO:0043983)2.92055398
68positive regulation of gene expression, epigenetic (GO:0045815)2.91976708
69positive regulation of T cell apoptotic process (GO:0070234)2.90619198
70peptidyl-lysine dimethylation (GO:0018027)2.90034466
71negative regulation of erythrocyte differentiation (GO:0045647)2.89173732
72chromatin silencing (GO:0006342)2.89065468
73negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.84436877
74motile cilium assembly (GO:0044458)2.84184392
75cellular extravasation (GO:0045123)2.84052249
76myeloid leukocyte mediated immunity (GO:0002444)2.83509951
77histone lysine methylation (GO:0034968)2.83123619
78T cell receptor signaling pathway (GO:0050852)2.82978184
79granulocyte activation (GO:0036230)2.82474864
80negative regulation of B cell apoptotic process (GO:0002903)2.82122390
81negative regulation of lymphocyte mediated immunity (GO:0002707)2.81033183
82B cell receptor signaling pathway (GO:0050853)2.80222884
83mannose metabolic process (GO:0006013)2.78773716
84regulation of mast cell degranulation (GO:0043304)2.76703845
85sperm motility (GO:0030317)2.75154503
86modulation by virus of host process (GO:0019054)2.74710632
87negative regulation of gene expression, epigenetic (GO:0045814)2.74529083
88negative regulation of interleukin-6 production (GO:0032715)2.72055006
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71224578
90gene silencing (GO:0016458)2.70973828
91alkaloid metabolic process (GO:0009820)2.69879145
92antigen processing and presentation of endogenous antigen (GO:0019883)2.69103221
93nuclear pore complex assembly (GO:0051292)2.68108174
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67776335
95negative regulation of translation, ncRNA-mediated (GO:0040033)2.67776335
96regulation of translation, ncRNA-mediated (GO:0045974)2.67776335
97antigen receptor-mediated signaling pathway (GO:0050851)2.66687834
98leukocyte aggregation (GO:0070486)2.66609811
99negative regulation of leukocyte mediated immunity (GO:0002704)2.65824057
100T cell migration (GO:0072678)2.65820880
101heterochromatin organization (GO:0070828)2.65655242
102modulation by symbiont of host cellular process (GO:0044068)2.64112312
103regulation of monocyte differentiation (GO:0045655)2.64024850
104regulation of T-helper 2 cell differentiation (GO:0045628)2.63579779
105detection of external biotic stimulus (GO:0098581)2.63177844
106mRNA stabilization (GO:0048255)2.62016049
107RNA stabilization (GO:0043489)2.62016049
108regulation of defense response to virus by virus (GO:0050690)2.61613663
109negative regulation of cAMP-mediated signaling (GO:0043951)2.61514150
110cell wall macromolecule catabolic process (GO:0016998)2.60446853
111leukocyte degranulation (GO:0043299)2.58950612
112regulation of myeloid leukocyte mediated immunity (GO:0002886)2.58463701
113regulation of T cell mediated cytotoxicity (GO:0001914)2.58441714
114positive regulation of granulocyte differentiation (GO:0030854)2.56871207
115cell junction maintenance (GO:0034331)2.56810099
116cellular response to virus (GO:0098586)2.56672621
117myeloid cell activation involved in immune response (GO:0002275)2.56361316
118positive regulation of Rab GTPase activity (GO:0032851)2.55575942
119regulation of Rab GTPase activity (GO:0032313)2.55575942
120histone H3-K36 demethylation (GO:0070544)2.55560108
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.54844738
122regulation of hydrogen peroxide metabolic process (GO:0010310)2.54572700
123positive regulation of protein deacetylation (GO:0090312)2.54431654
124histone H4-K16 acetylation (GO:0043984)2.54392632
125glucocorticoid receptor signaling pathway (GO:0042921)2.52992421
126histone H4 acetylation (GO:0043967)2.51935755
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51410447
128NIK/NF-kappaB signaling (GO:0038061)2.51303839
129regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.50490196
130peptidyl-lysine trimethylation (GO:0018023)2.49453587
131regulation of regulatory T cell differentiation (GO:0045589)2.49393865
132acrosome reaction (GO:0007340)2.48413581
133fusion of sperm to egg plasma membrane (GO:0007342)2.47738843
134positive regulation of tolerance induction (GO:0002645)2.47654803
135regulation of B cell differentiation (GO:0045577)2.47067241
136positive regulation of RNA splicing (GO:0033120)2.47051476
137histone methylation (GO:0016571)2.45086654
138positive regulation of mRNA catabolic process (GO:0061014)2.44686073
139negative regulation of glial cell proliferation (GO:0060253)2.44449329
140response to muramyl dipeptide (GO:0032495)2.43705305
141apoptotic process involved in morphogenesis (GO:0060561)2.43672864
142positive regulation of CREB transcription factor activity (GO:0032793)2.43371194
143gene silencing by RNA (GO:0031047)2.39020569
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.35799649
145regulation of T cell tolerance induction (GO:0002664)2.35599510
146regulation of histone deacetylation (GO:0031063)2.35397565
147histone H4-K8 acetylation (GO:0043982)2.35029825
148histone H4-K5 acetylation (GO:0043981)2.35029825
149negative regulation of interleukin-12 production (GO:0032695)2.34474996
150regulation of interleukin-2 biosynthetic process (GO:0045076)2.33274118
151negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.33096431
152cell-cell recognition (GO:0009988)2.32561734
153histone H3 acetylation (GO:0043966)2.31810619
154mitotic sister chromatid cohesion (GO:0007064)2.31730013
155regulation of mRNA catabolic process (GO:0061013)2.31697437
156negative regulation of granulocyte differentiation (GO:0030853)2.31065815
157regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.29744537
158positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.29744537
159T cell costimulation (GO:0031295)2.29599142
160internal peptidyl-lysine acetylation (GO:0018393)2.29543356
161DNA alkylation (GO:0006305)2.28863903
162DNA methylation (GO:0006306)2.28863903
163natural killer cell differentiation (GO:0001779)2.28142662
1643-UTR-mediated mRNA stabilization (GO:0070935)2.28132437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.56397897
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.81754087
3VDR_21846776_ChIP-Seq_THP-1_Human3.27090812
4TCF7_22412390_ChIP-Seq_EML_Mouse3.20889425
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.14209353
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.96745564
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.92016271
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.83976118
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.78861091
10KDM2B_26808549_Chip-Seq_DND41_Human2.78632565
11EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.78004706
12E2F7_22180533_ChIP-Seq_HELA_Human2.60514700
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.57327245
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56733560
15* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.54064765
16UTX_26944678_Chip-Seq_JUKART_Human2.52257411
17KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.50019344
18MAF_26560356_Chip-Seq_TH1_Human2.47927534
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.39310354
20SCL_19346495_ChIP-Seq_HPC-7_Human2.38982390
21MYB_26560356_Chip-Seq_TH1_Human2.17317795
22RUNX_20019798_ChIP-Seq_JUKART_Human2.08683701
23MYB_26560356_Chip-Seq_TH2_Human2.07378514
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.07308035
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.99068046
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.96114116
27LXR_22292898_ChIP-Seq_THP-1_Human1.95694262
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.94904774
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.92847070
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91351206
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.90533717
32VDR_24763502_ChIP-Seq_THP-1_Human1.87410880
33ZFP281_27345836_Chip-Seq_ESCs_Mouse1.86242004
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.85028343
35MAF_26560356_Chip-Seq_TH2_Human1.83632442
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.80400707
37CTCF_27219007_Chip-Seq_Bcells_Human1.73712717
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68161804
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65645919
40* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65452274
41CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.61302745
42KDM2B_26808549_Chip-Seq_K562_Human1.60756882
43CIITA_25753668_ChIP-Seq_RAJI_Human1.59986307
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59397606
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.58844188
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.56627147
47SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54592126
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50673376
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.49681896
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49578965
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47538823
52* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46008618
53SA1_27219007_Chip-Seq_Bcells_Human1.44932535
54SPI1_23127762_ChIP-Seq_K562_Human1.43165949
55ELF1_20517297_ChIP-Seq_JURKAT_Human1.42230627
56* P68_20966046_ChIP-Seq_HELA_Human1.41516054
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40769999
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.39149921
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.36797130
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35934178
61RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.35357007
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34302086
63* NCOR1_26117541_ChIP-Seq_K562_Human1.33983853
64TP53_22127205_ChIP-Seq_IMR90_Human1.33342243
65IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32778492
66* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31058150
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30864861
68TP63_22573176_ChIP-Seq_HFKS_Human1.30353781
69CTCF_20526341_ChIP-Seq_ESCs_Human1.29942415
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29766223
71CTCF_21964334_Chip-Seq_Bcells_Human1.29311492
72MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.28734484
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.28502480
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28090981
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28046708
76* GATA1_19941826_ChIP-Seq_K562_Human1.27838147
77* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25717771
78* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25231536
79* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24966574
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24792804
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24617944
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24280534
83* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23562959
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.22250400
85OCT4_19829295_ChIP-Seq_ESCs_Human1.21192925
86CTCF_26484167_Chip-Seq_Bcells_Mouse1.20122768
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20006723
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.19811344
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19268187
90* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18291604
91PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16022766
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15891087
93FOXP1_21924763_ChIP-Seq_HESCs_Human1.15768474
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15235046
95* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15210645
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15143607
97SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14339146
98NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13956024
99RARB_24833708_ChIP-Seq_LIVER_Mouse1.13669341
100* PHF8_20622854_ChIP-Seq_HELA_Human1.13481740
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13436355
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13350658
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.12789076
104GATA1_19941827_ChIP-Seq_MEL_Mouse1.12694526
105* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12627192
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11936238
107BCOR_27268052_Chip-Seq_Bcells_Human1.11622596
108* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.11590474
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.10252062
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09626540
111SMC4_20622854_ChIP-Seq_HELA_Human1.07946781
112P300_27268052_Chip-Seq_Bcells_Human1.07931356
113IRF8_27001747_Chip-Seq_BMDM_Mouse1.07174351
114* ETS1_21867929_ChIP-Seq_TH2_Mouse1.07004042
115E2F1_20622854_ChIP-Seq_HELA_Human1.04007293
116BCL6_27268052_Chip-Seq_Bcells_Human1.03664562
117* RACK7_27058665_Chip-Seq_MCF-7_Human1.03449015
118DROSHA_22980978_ChIP-Seq_HELA_Human1.03062489
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02827204
120* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02404188
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02276253
122RARB_27405468_Chip-Seq_BRAIN_Mouse1.02092415
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02013692
124CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01757487
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01296356
126RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.01049318
127EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99944658
128GATA3_27048872_Chip-Seq_THYMUS_Human0.99576077
129* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99081796
130TET1_21451524_ChIP-Seq_MESCs_Mouse0.96294611
131NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95627399
132* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95054989
133BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94595449
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.94490712
135IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.94411409
136CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91814252
137FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91489099
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91232262
139* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91105534
140CREB1_26743006_Chip-Seq_LNCaP_Human0.89931545
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.89155360
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88917799

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.88845047
2MP0003878_abnormal_ear_physiology3.88845047
3MP0003763_abnormal_thymus_physiology3.40895527
4MP0009278_abnormal_bone_marrow2.84449944
5MP0000685_abnormal_immune_system2.67323907
6MP0005410_abnormal_fertilization2.63553898
7MP0003724_increased_susceptibility_to2.59701361
8MP0000678_abnormal_parathyroid_gland2.45424715
9MP0002653_abnormal_ependyma_morphology2.40262096
10MP0003172_abnormal_lysosome_physiology2.39115997
11MP0002396_abnormal_hematopoietic_system2.36624763
12MP0008961_abnormal_basal_metabolism2.36581424
13MP0003303_peritoneal_inflammation2.34386243
14MP0001800_abnormal_humoral_immune2.30057643
15MP0004808_abnormal_hematopoietic_stem2.24627251
16MP0001790_abnormal_immune_system2.20547618
17MP0005387_immune_system_phenotype2.20547618
18MP0002398_abnormal_bone_marrow2.18597113
19MP0002249_abnormal_larynx_morphology2.12717702
20MP0000703_abnormal_thymus_morphology2.11903224
21MP0005076_abnormal_cell_differentiation2.10438048
22MP0001873_stomach_inflammation2.00198896
23MP0004510_myositis1.95438915
24MP0008260_abnormal_autophagy1.92705916
25MP0005423_abnormal_somatic_nervous1.90438471
26MP0002405_respiratory_system_inflammati1.89902802
27MP0002452_abnormal_antigen_presenting1.88410921
28MP0001545_abnormal_hematopoietic_system1.87479958
29MP0005397_hematopoietic_system_phenotyp1.87479958
30MP0002420_abnormal_adaptive_immunity1.85086727
31MP0001819_abnormal_immune_cell1.82470249
32MP0002723_abnormal_immune_serum1.81588832
33MP0003787_abnormal_imprinting1.80727262
34MP0005671_abnormal_response_to1.79413789
35MP0004381_abnormal_hair_follicle1.79243062
36MP0001835_abnormal_antigen_presentation1.78039712
37MP0003111_abnormal_nucleus_morphology1.74927374
38MP0008877_abnormal_DNA_methylation1.74124798
39MP0000716_abnormal_immune_system1.73792394
40MP0001348_abnormal_lacrimal_gland1.73617851
41MP0002722_abnormal_immune_system1.66920771
42MP0001533_abnormal_skeleton_physiology1.64483510
43MP0003866_abnormal_defecation1.63702269
44MP0008995_early_reproductive_senescence1.63115494
45MP0000689_abnormal_spleen_morphology1.59205313
46MP0009333_abnormal_splenocyte_physiolog1.52905738
47MP0003879_abnormal_hair_cell1.52145333
48MP0000569_abnormal_digit_pigmentation1.51163941
49MP0005000_abnormal_immune_tolerance1.50412357
50MP0009785_altered_susceptibility_to1.47008917
51MP0003436_decreased_susceptibility_to1.45564771
52MP0002429_abnormal_blood_cell1.44935082
53MP0003300_gastrointestinal_ulcer1.42110739
54MP0005451_abnormal_body_composition1.36418058
55MP0010155_abnormal_intestine_physiology1.31997183
56MP0000490_abnormal_crypts_of1.31326860
57MP0003011_delayed_dark_adaptation1.23845230
58MP0010094_abnormal_chromosome_stability1.22210862
59MP0003077_abnormal_cell_cycle1.22094668
60MP0005409_darkened_coat_color1.21692607
61MP0010352_gastrointestinal_tract_polyps1.20561672
62MP0003698_abnormal_male_reproductive1.20341735
63MP0004947_skin_inflammation1.18815707
64MP0010030_abnormal_orbit_morphology1.18480293
65MP0001929_abnormal_gametogenesis1.18024264
66MP0005058_abnormal_lysosome_morphology1.17118137
67MP0005670_abnormal_white_adipose1.16416719
68MP0004859_abnormal_synaptic_plasticity1.13525238
69MP0005025_abnormal_response_to1.13307458
70MP0001853_heart_inflammation1.12801576
71MP0002148_abnormal_hypersensitivity_rea1.11423916
72MP0006292_abnormal_olfactory_placode1.10233766
73MP0004858_abnormal_nervous_system1.08728889
74MP0002277_abnormal_respiratory_mucosa1.06309882
75MP0000350_abnormal_cell_proliferation1.06300854
76MP0004145_abnormal_muscle_electrophysio1.05087083
77MP0002822_catalepsy1.04932928
78MP0001663_abnormal_digestive_system1.04870209
79MP0003123_paternal_imprinting1.03877773
80MP0002419_abnormal_innate_immunity1.02909075
81MP0002733_abnormal_thermal_nociception1.01412877
82MP0003828_pulmonary_edema1.00097583
83MP0003693_abnormal_embryo_hatching0.99588196
84MP0003121_genomic_imprinting0.98965942
85MP0000858_altered_metastatic_potential0.98464326
86MP0003045_fibrosis0.96628943
87MP0004742_abnormal_vestibular_system0.95785171
88MP0005464_abnormal_platelet_physiology0.95749435
89MP0003705_abnormal_hypodermis_morpholog0.94659974
90MP0005310_abnormal_salivary_gland0.92899772
91MP0005083_abnormal_biliary_tract0.92412905
92MP0002019_abnormal_tumor_incidence0.91573844
93MP0000313_abnormal_cell_death0.91498019
94MP0008007_abnormal_cellular_replicative0.91406507
95MP0003656_abnormal_erythrocyte_physiolo0.91260680
96MP0002928_abnormal_bile_duct0.90629974
97MP0005390_skeleton_phenotype0.89340908
98MP0002006_tumorigenesis0.89289487
99MP0001849_ear_inflammation0.89012418
100MP0002089_abnormal_postnatal_growth/wei0.88641086
101MP0003075_altered_response_to0.87676215
102MP0000733_abnormal_muscle_development0.87561228
103MP0002210_abnormal_sex_determination0.87296132
104MP0002925_abnormal_cardiovascular_devel0.86195641
105MP0003091_abnormal_cell_migration0.84328249
106MP0001293_anophthalmia0.84019570
107MP0002132_abnormal_respiratory_system0.83320587
108MP0003329_amyloid_beta_deposits0.83264748
109MP0009764_decreased_sensitivity_to0.83240103
110MP0003984_embryonic_growth_retardation0.83071474
111MP0000470_abnormal_stomach_morphology0.82835798
112MP0002166_altered_tumor_susceptibility0.82534671
113MP0003115_abnormal_respiratory_system0.81179507
114MP0002088_abnormal_embryonic_growth/wei0.81116145
115MP0008057_abnormal_DNA_replication0.81085178
116MP0000566_synostosis0.80499974
117MP0008469_abnormal_protein_level0.80422007
118MP0005174_abnormal_tail_pigmentation0.80352150
119MP0002084_abnormal_developmental_patter0.80199162
120MP0001440_abnormal_grooming_behavior0.80172606
121MP0001845_abnormal_inflammatory_respons0.80154146
122MP0005380_embryogenesis_phenotype0.79838387
123MP0001672_abnormal_embryogenesis/_devel0.79838387
124MP0003786_premature_aging0.79512843
125MP0003566_abnormal_cell_adhesion0.78232513
126MP0000465_gastrointestinal_hemorrhage0.78189574
127MP0002086_abnormal_extraembryonic_tissu0.77731445
128MP0001970_abnormal_pain_threshold0.77599879
129MP0004197_abnormal_fetal_growth/weight/0.77341575
130MP0003279_aneurysm0.76912117
131MP0004130_abnormal_muscle_cell0.75548817
132MP0002254_reproductive_system_inflammat0.75424250
133MP0005381_digestive/alimentary_phenotyp0.75074921
134MP0002933_joint_inflammation0.75001335
135MP0003448_altered_tumor_morphology0.73568779
136MP0008770_decreased_survivor_rate0.73423492
137MP0001730_embryonic_growth_arrest0.73032079
138MP0006082_CNS_inflammation0.72689647
139MP0002998_abnormal_bone_remodeling0.72350331
140MP0000428_abnormal_craniofacial_morphol0.70948595
141MP0000049_abnormal_middle_ear0.70702812
142MP0009053_abnormal_anal_canal0.70361362
143MP0002138_abnormal_hepatobiliary_system0.69717643
144MP0003942_abnormal_urinary_system0.69543612
145MP0009840_abnormal_foam_cell0.68471596
146MP0000681_abnormal_thyroid_gland0.68105516
147MP0001502_abnormal_circadian_rhythm0.65156058

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)4.60801518
2Abnormality of the fingertips (HP:0001211)4.51898169
3Elevated erythrocyte sedimentation rate (HP:0003565)4.36612848
4Nasal polyposis (HP:0100582)4.25215274
5Chronic obstructive pulmonary disease (HP:0006510)4.19939330
6Obstructive lung disease (HP:0006536)4.19939330
7Eczematoid dermatitis (HP:0000976)3.98300898
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.81024996
9Stomatitis (HP:0010280)3.77998860
10Abnormality of the nasal mucosa (HP:0000433)3.51937445
11Recurrent abscess formation (HP:0002722)3.46660816
12Hyperthyroidism (HP:0000836)3.28754670
13Abnormality of macrophages (HP:0004311)3.26918172
14Recurrent bacterial skin infections (HP:0005406)3.19191623
15Orchitis (HP:0100796)3.18794144
16Recurrent bronchitis (HP:0002837)3.13694304
17Obstructive sleep apnea (HP:0002870)3.12629312
18Absent/shortened dynein arms (HP:0200106)3.12021463
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.12021463
20Hypochromic anemia (HP:0001931)3.05921364
21Gastrointestinal infarctions (HP:0005244)2.94792589
22Abnormality of the aortic arch (HP:0012303)2.93421117
23Hyperacusis (HP:0010780)2.87488548
24Thin bony cortex (HP:0002753)2.85591967
25Heterotopia (HP:0002282)2.76221951
26Chronic otitis media (HP:0000389)2.74359976
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.70257398
28Hypochromic microcytic anemia (HP:0004840)2.65849145
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.62017018
30Abnormality of the heme biosynthetic pathway (HP:0010472)2.61940868
31Recurrent gram-negative bacterial infections (HP:0005420)2.60033777
32Recurrent fungal infections (HP:0002841)2.57083017
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.56726799
34Increased cerebral lipofuscin (HP:0011813)2.54077656
35Optic neuritis (HP:0100653)2.53390582
36Retrobulbar optic neuritis (HP:0100654)2.53390582
37T lymphocytopenia (HP:0005403)2.51860568
38Hypertensive crisis (HP:0100735)2.51821197
39Recurrent sinusitis (HP:0011108)2.50494188
40Gingivitis (HP:0000230)2.49776812
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.49174945
42Panhypogammaglobulinemia (HP:0003139)2.43077153
43Episodic fever (HP:0001954)2.41842837
44Long eyelashes (HP:0000527)2.41230968
45Easy fatigability (HP:0003388)2.41023977
46Cerebral aneurysm (HP:0004944)2.40236708
47Gastrointestinal inflammation (HP:0004386)2.39443446
48Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37211445
49Short 4th metacarpal (HP:0010044)2.37211445
50Recurrent skin infections (HP:0001581)2.35139171
51Recurrent cutaneous fungal infections (HP:0011370)2.34097798
52Chronic mucocutaneous candidiasis (HP:0002728)2.34097798
53Inflammation of the large intestine (HP:0002037)2.30188053
54Colitis (HP:0002583)2.29941960
55Abnormality of T cell number (HP:0011839)2.29745272
56Recurrent otitis media (HP:0000403)2.28901537
57Bronchitis (HP:0012387)2.28521473
58Limited elbow extension (HP:0001377)2.26464027
59Abnormal rod and cone electroretinograms (HP:0008323)2.26457332
60Truncus arteriosus (HP:0001660)2.25182218
61Abnormality of lateral ventricle (HP:0030047)2.24171207
62Peritonitis (HP:0002586)2.23833451
63Vasculitis (HP:0002633)2.23724147
64Recurrent viral infections (HP:0004429)2.23510893
65Chronic sinusitis (HP:0011109)2.22182065
66Asymmetric septal hypertrophy (HP:0001670)2.20906783
67IgM deficiency (HP:0002850)2.20080813
68Mediastinal lymphadenopathy (HP:0100721)2.18256564
69Dysmetric saccades (HP:0000641)2.16891107
70Joint stiffness (HP:0001387)2.16271214
71Pustule (HP:0200039)2.15967553
72Reticulocytosis (HP:0001923)2.15008982
73Urticaria (HP:0001025)2.14740002
74Increased nuchal translucency (HP:0010880)2.14348182
75Basal cell carcinoma (HP:0002671)2.12155249
76Rhinitis (HP:0012384)2.11735846
77Prominent nose (HP:0000448)2.09483276
78Genetic anticipation (HP:0003743)2.09148227
79Encephalitis (HP:0002383)2.07747851
80Anal stenosis (HP:0002025)2.07625353
81Chest pain (HP:0100749)2.07326378
82Bronchiectasis (HP:0002110)2.06987875
83Abnormal respiratory epithelium morphology (HP:0012253)2.06089540
84Abnormal respiratory motile cilium morphology (HP:0005938)2.06089540
85Abnormal number of incisors (HP:0011064)2.05054419
86Rib fusion (HP:0000902)2.04948180
87Acne (HP:0001061)2.04719327
88Stridor (HP:0010307)2.04427646
89Agammaglobulinemia (HP:0004432)2.04223965
90Ectopic kidney (HP:0000086)2.02596008
91Atelectasis (HP:0100750)2.02368317
92Cheilitis (HP:0100825)2.01756093
93Aplasia/Hypoplasia of the thymus (HP:0010515)2.00890145
94Neoplasm of the heart (HP:0100544)1.99597903
95Myositis (HP:0100614)1.99285068
96Renovascular hypertension (HP:0100817)1.97985879
97Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.97480183
98Ulnar bowing (HP:0003031)1.96007808
99Epistaxis (HP:0000421)1.94506771
100Trigonocephaly (HP:0000243)1.90365965
101Abnormality of the intervertebral disk (HP:0005108)1.89583999
102Abnormality of DNA repair (HP:0003254)1.89352689
103Cellulitis (HP:0100658)1.88383145
104Vertebral arch anomaly (HP:0008438)1.88139330
105Abnormality of cells of the lymphoid lineage (HP:0012140)1.86809107
106Thoracic kyphosis (HP:0002942)1.86013992
107Upper motor neuron abnormality (HP:0002127)1.83931598
108Increased serum ferritin (HP:0003281)1.83744359
109Autoimmune thrombocytopenia (HP:0001973)1.83339732
110Keratoconjunctivitis sicca (HP:0001097)1.82958305
111Papilloma (HP:0012740)1.82098002
112Verrucae (HP:0200043)1.82098002
113Elfin facies (HP:0004428)1.81848661
114Abnormality of T cells (HP:0002843)1.81831312
115Abnormal respiratory motile cilium physiology (HP:0012261)1.81572146
116Petechiae (HP:0000967)1.81128310
117Bowel incontinence (HP:0002607)1.81015278
118Seborrheic dermatitis (HP:0001051)1.80679819
119Dislocated radial head (HP:0003083)1.80302502
120Ependymoma (HP:0002888)1.79822884
121Skin tags (HP:0010609)1.78803745
122Lymphopenia (HP:0001888)1.78689645
123Metaphyseal cupping (HP:0003021)1.77042138
124Microcytic anemia (HP:0001935)1.76932437
125Broad palm (HP:0001169)1.75818246
126Optic nerve coloboma (HP:0000588)1.75708932
127Testicular atrophy (HP:0000029)1.75089404
128Myokymia (HP:0002411)1.74553006
129Hand muscle atrophy (HP:0009130)1.74339258
130Abnormality of the lower motor neuron (HP:0002366)1.73463881
131Spinal canal stenosis (HP:0003416)1.73387053
132Pointed chin (HP:0000307)1.73296405
133Keratoconjunctivitis (HP:0001096)1.72921657
134Depressed nasal tip (HP:0000437)1.72225261
135Upper limb amyotrophy (HP:0009129)1.71508677
136Distal upper limb amyotrophy (HP:0007149)1.71508677
137Purpura (HP:0000979)1.71452821
138Broad face (HP:0000283)1.70824568
139Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70582060
140Cerebral palsy (HP:0100021)1.70216570
141Abnormality of the costochondral junction (HP:0000919)1.67912865
142Macroorchidism (HP:0000053)1.67679455
143Abnormality of the radial head (HP:0003995)1.67063365
144Gastrointestinal stroma tumor (HP:0100723)1.66205026
145Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65569718
146Recurrent lower respiratory tract infections (HP:0002783)1.65321253
147Abnormal large intestine physiology (HP:0012700)1.65208286
148Abnormality of the columella (HP:0009929)1.64944267
149Plagiocephaly (HP:0001357)1.63809290
150Pulmonary infiltrates (HP:0002113)1.63200961
151Obsessive-compulsive behavior (HP:0000722)1.62430259
152Leukocytosis (HP:0001974)1.62181124
153Truncal obesity (HP:0001956)1.62129403
154Prolonged bleeding time (HP:0003010)1.61871092
155Meningitis (HP:0001287)1.61506535
156Recurrent pneumonia (HP:0006532)1.58611801
157Abnormality of the peritoneum (HP:0002585)1.58347429
158Short femoral neck (HP:0100864)1.58213858
159Narrow palate (HP:0000189)1.57633817
160Oligodontia (HP:0000677)1.57187638
161Genu recurvatum (HP:0002816)1.55986737
162Bony spicule pigmentary retinopathy (HP:0007737)1.55896252
163Supernumerary ribs (HP:0005815)1.55765892
164Absent frontal sinuses (HP:0002688)1.54662005
165Long palpebral fissure (HP:0000637)1.53449663
166Abnormality of the nasal septum (HP:0000419)1.53003299
167Porencephaly (HP:0002132)1.52542486
168Increased IgE level (HP:0003212)1.49697231
169Urethral obstruction (HP:0000796)1.49363500
170Emphysema (HP:0002097)1.44759270
171Intestinal fistula (HP:0100819)1.44501842
172Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.44164331
173Renal duplication (HP:0000075)1.43825919
174Combined immunodeficiency (HP:0005387)1.42040991
175Neoplasm of striated muscle (HP:0009728)1.41985532

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.99021246
2CDK123.87740183
3MAP3K103.61503873
4SIK23.26555831
5ICK2.99246881
6EEF2K2.86553963
7BRD42.74859905
8MAP3K112.66129616
9SMG12.46524515
10TRIB32.13124660
11GRK62.09222728
12SIK31.89708791
13BCKDK1.88535171
14STK101.88145283
15TXK1.78417299
16NEK21.69305637
17ERN11.55126956
18ZAP701.54100244
19TESK21.51993980
20MAPK151.48357338
21STK381.44781508
22PKN21.44287456
23TAOK11.43104693
24JAK31.43084194
25MAP3K71.42477071
26SIK11.41015589
27MAP3K131.40551179
28PRKD21.40163173
29BLK1.38472770
30PRKD31.36863050
31MARK21.34605663
32BTK1.34204141
33FGFR31.27840312
34ITK1.25989614
35MARK31.23624116
36TYRO31.22870526
37CAMK1G1.18930134
38IKBKE1.14744304
39CHUK1.13497325
40ALK1.12016972
41MAP2K21.10004471
42TESK11.09394583
43MAP3K31.09316726
44TBK11.05195546
45PTK61.04362512
46HCK1.03932643
47TNK21.03194399
48INSRR0.99562825
49CLK10.98001252
50PRKCH0.96987713
51PIM10.96612668
52DYRK1B0.95404082
53MTOR0.95259835
54CDK40.91461243
55TAOK20.90471718
56EPHB10.88987340
57JAK10.88699933
58MAP3K140.88108835
59TYK20.87427741
60MAP3K10.87202701
61FGFR40.86824280
62PDPK10.86110859
63IRAK30.84463799
64SGK30.84250802
65CAMK1D0.82318956
66CAMKK10.81787666
67CAMK40.81581260
68LCK0.81299907
69DMPK0.80493187
70MAPK70.79934934
71SYK0.78848502
72CSK0.75291502
73RPS6KC10.74582953
74RPS6KL10.74582953
75RPS6KA60.74167413
76RPS6KA20.73348837
77CDK60.72986653
78IKBKB0.70337523
79TTN0.70223351
80TGFBR20.69123537
81RIPK40.66817026
82CDK190.66696517
83RIPK10.65799836
84PTK2B0.61911606
85PRPF4B0.61802043
86STK40.61471189
87BMX0.60265728
88CDK90.59451246
89RPS6KA40.59371304
90ATR0.58813360
91DYRK30.58448777
92KDR0.58140132
93PRKCZ0.57918445
94CHEK10.57809205
95IRAK40.56399012
96NTRK20.55562234
97EPHA30.55239584
98CDK70.54974786
99PRKG20.54787618
100PAK40.54288440
101CDC42BPA0.52957415
102LYN0.52721237
103HIPK20.52154690
104SGK20.51913785
105DYRK20.51809311
106MAP2K30.50025642
107DAPK20.49376029
108MATK0.49270313
109RPS6KA10.48242034
110ARAF0.48181202
111CAMK10.47903245
112STK110.45878886
113CDK20.45765310
114FGFR10.45758826
115NLK0.44429619
116PDGFRB0.44230610
117CDC70.43983317
118KIT0.43648007
119CSF1R0.42290142
120TLK10.41843387
121PDK10.41686479
122FES0.40808018
123JAK20.40184109
124MAPKAPK20.38748844
125AKT10.37427624
126AURKA0.37370681
127PRKCQ0.37270844
128TEC0.37090973
129PLK40.37030022
130LRRK20.36890123
131MAPK80.36313985
132BRAF0.36133120
133MAPK120.35920360
134ERBB20.35225567
135PAK10.33550998

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.68134955
2B cell receptor signaling pathway_Homo sapiens_hsa046622.14090991
3T cell receptor signaling pathway_Homo sapiens_hsa046601.91885641
4Allograft rejection_Homo sapiens_hsa053301.80004552
5Graft-versus-host disease_Homo sapiens_hsa053321.77480345
6Autoimmune thyroid disease_Homo sapiens_hsa053201.75194083
7Notch signaling pathway_Homo sapiens_hsa043301.74731516
8Acute myeloid leukemia_Homo sapiens_hsa052211.60453308
9Sulfur relay system_Homo sapiens_hsa041221.56623934
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.56547602
11Osteoclast differentiation_Homo sapiens_hsa043801.54531824
12Type I diabetes mellitus_Homo sapiens_hsa049401.51860922
13Measles_Homo sapiens_hsa051621.47165463
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46626354
15Chronic myeloid leukemia_Homo sapiens_hsa052201.45862866
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45824294
17Staphylococcus aureus infection_Homo sapiens_hsa051501.43279752
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42129988
19mRNA surveillance pathway_Homo sapiens_hsa030151.40392243
20Malaria_Homo sapiens_hsa051441.35410024
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35367312
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34408883
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30229563
24Lysine degradation_Homo sapiens_hsa003101.27671292
25HTLV-I infection_Homo sapiens_hsa051661.26802339
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.22700247
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18134502
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17924508
29Leishmaniasis_Homo sapiens_hsa051401.17912616
30Herpes simplex infection_Homo sapiens_hsa051681.17881832
31mTOR signaling pathway_Homo sapiens_hsa041501.16530886
32Base excision repair_Homo sapiens_hsa034101.16328100
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13359018
34Hematopoietic cell lineage_Homo sapiens_hsa046401.12618196
35Glycerophospholipid metabolism_Homo sapiens_hsa005641.12320016
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.10317112
37Colorectal cancer_Homo sapiens_hsa052101.10140073
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.09726754
39Type II diabetes mellitus_Homo sapiens_hsa049301.09531743
40Non-small cell lung cancer_Homo sapiens_hsa052231.06065523
41Hepatitis B_Homo sapiens_hsa051611.04909155
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04748755
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.03556858
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.03411350
45Antigen processing and presentation_Homo sapiens_hsa046121.03233601
46Chemokine signaling pathway_Homo sapiens_hsa040621.02205543
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.02061692
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.01565516
49Influenza A_Homo sapiens_hsa051640.99441655
50MAPK signaling pathway_Homo sapiens_hsa040100.98419923
51Dorso-ventral axis formation_Homo sapiens_hsa043200.98236740
52Apoptosis_Homo sapiens_hsa042100.97675764
53Toxoplasmosis_Homo sapiens_hsa051450.96981757
54VEGF signaling pathway_Homo sapiens_hsa043700.96262677
55Endometrial cancer_Homo sapiens_hsa052130.93613239
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93391193
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92242154
58Viral myocarditis_Homo sapiens_hsa054160.92161982
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91629887
60Inositol phosphate metabolism_Homo sapiens_hsa005620.90544361
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89848445
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89830462
63Basal cell carcinoma_Homo sapiens_hsa052170.89824871
64Olfactory transduction_Homo sapiens_hsa047400.88942290
65Hepatitis C_Homo sapiens_hsa051600.87928308
66MicroRNAs in cancer_Homo sapiens_hsa052060.86499351
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86231626
68TNF signaling pathway_Homo sapiens_hsa046680.85403844
69Pancreatic cancer_Homo sapiens_hsa052120.85393219
70Spliceosome_Homo sapiens_hsa030400.83001471
71Small cell lung cancer_Homo sapiens_hsa052220.82322371
72Platelet activation_Homo sapiens_hsa046110.82147620
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81801268
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81307084
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.80619640
76Renal cell carcinoma_Homo sapiens_hsa052110.79291067
77Prolactin signaling pathway_Homo sapiens_hsa049170.78090175
78Other glycan degradation_Homo sapiens_hsa005110.77332493
79Choline metabolism in cancer_Homo sapiens_hsa052310.77106259
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75821935
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74702353
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74691766
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.74481281
84Estrogen signaling pathway_Homo sapiens_hsa049150.73866098
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73729632
86Viral carcinogenesis_Homo sapiens_hsa052030.73240816
87Insulin resistance_Homo sapiens_hsa049310.72515580
88Shigellosis_Homo sapiens_hsa051310.71187826
89Cholinergic synapse_Homo sapiens_hsa047250.70963182
90Glioma_Homo sapiens_hsa052140.70630492
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70338494
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.68412300
93Prostate cancer_Homo sapiens_hsa052150.68349388
94Bladder cancer_Homo sapiens_hsa052190.67913880
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67777322
96Rap1 signaling pathway_Homo sapiens_hsa040150.67696949
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67630374
98Epstein-Barr virus infection_Homo sapiens_hsa051690.66727697
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66283118
100HIF-1 signaling pathway_Homo sapiens_hsa040660.66279963
101Phagosome_Homo sapiens_hsa041450.65891853
102FoxO signaling pathway_Homo sapiens_hsa040680.65462284
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65053349
104Regulation of autophagy_Homo sapiens_hsa041400.63900124
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63769341
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63439147
107ErbB signaling pathway_Homo sapiens_hsa040120.62567152
108Proteoglycans in cancer_Homo sapiens_hsa052050.62104686
109Pathways in cancer_Homo sapiens_hsa052000.61518258
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.61436789
111Oxytocin signaling pathway_Homo sapiens_hsa049210.61051377
112Long-term potentiation_Homo sapiens_hsa047200.60091538
113Fanconi anemia pathway_Homo sapiens_hsa034600.59903820
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59503248
115Tuberculosis_Homo sapiens_hsa051520.58945333
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58636126
117Endocytosis_Homo sapiens_hsa041440.58286272
118Salmonella infection_Homo sapiens_hsa051320.58142101
119Wnt signaling pathway_Homo sapiens_hsa043100.57167250
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57008598
121Adherens junction_Homo sapiens_hsa045200.56843254
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56558141
123GnRH signaling pathway_Homo sapiens_hsa049120.56477036
124Lysosome_Homo sapiens_hsa041420.56385606
125Circadian entrainment_Homo sapiens_hsa047130.55883818
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52519038
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52507680
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51561814
129Morphine addiction_Homo sapiens_hsa050320.51191417
130Insulin signaling pathway_Homo sapiens_hsa049100.51014798
131Gastric acid secretion_Homo sapiens_hsa049710.50186396
132African trypanosomiasis_Homo sapiens_hsa051430.46686337
133Asthma_Homo sapiens_hsa053100.44424770

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